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Institute of Metabolic Science

Metabolic Research Laboratories
 
Read more at: Cambridge researchers map the human endocrine system cell by cell
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Cambridge researchers map the human endocrine system cell by cell

28 May 2026

Researchers at the University of Cambridge have constructed the most comprehensive map to date of where hormones are made and where they work – the Hormone Cell Atlas . Hormones are chemical messengers that are secreted into the blood and act on distant sites in the body to orchestrate fundamental processes, including...


Read more at: Professor Giles Yeo elected as a Fellow of the Academy of Medical Sciences
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Professor Giles Yeo elected as a Fellow of the Academy of Medical Sciences

19 May 2026

The Academy of Medical Sciences (AMS) has announced its newly elected biomedical and health scientists to its prestigious Fellowship, and we are delighted that Professor Giles Yeo from the IMS-MRL is included in the list of 60 exceptional researchers. Giles is Professor of Molecular Neuroendocrinology at the University of...


Read more at: TV nutrition and health experts raise a glass to science at Cambridge’s Pint of Science festival
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TV nutrition and health experts raise a glass to science at Cambridge’s Pint of Science festival

12 May 2026

TV nutrition and health experts will take centre stage alongside astronomers, neuroscientists and AI experts at the annual Pint of Science festival next week, with public talks in the unlikeliest of ‘lecture theatres’ – local Cambridge pubs. This year’s festival (18 th – 20 th May)_ will see twice as many events taking...


Read more at: Physiological mechanisms mediating socio-environmental influences on pregnancy outcomes in Black people
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Physiological mechanisms mediating socio-environmental influences on pregnancy outcomes in Black people

29 April 2026

A University of Cambridge study led by Dr Grace Amedor and Professor Dino Giussani , an affiliated PI at the IMS-MRL and both based in the Department of Physiology, Development and Neuroscience, has found that stresses such as systemic racism and socioeconomic disadvantage may sensitise key processes in the body during...


Read more at: Why do high-protein diets make you feel full? Scientists discover a molecular answer
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Why do high-protein diets make you feel full? Scientists discover a molecular answer

21 April 2026

We all know that eating a high-protein meal tends to keep you fuller for longer than a high-carb or high-fat meal. But the brain mechanisms behind this have remained largely mysterious - until now. A new study published in Cell Metabolism has identified a surprising molecular player: a protein called Cav3.1, a calcium...


Read more at: Hidden mutations in immune cells point to a new mechanism in thyroid autoimmunity
Spatial transcriptomics of thyroid tissue from a donor with autoimmune thyroid disease.

Hidden mutations in immune cells point to a new mechanism in thyroid autoimmunity

13 April 2026

Scientists in Cambridge have found evidence linking genetic changes that occur throughout our lives to autoimmune diseases, where cells from the immune system attack healthy cells. Published in Nature , the pioneering genetic analysis has revealed how somatic mutations – genetic changes that occur throughout our lives –...


Read more at: Obesity Prize for Excellence awarded to Professor Sadaf Farooqi for distinguished and innovative work in obesity and Its complications
Sadaf Farooqi award winner

Obesity Prize for Excellence awarded to Professor Sadaf Farooqi for distinguished and innovative work in obesity and Its complications

19 March 2026

We are delighted to announce that Professor Sadaf Farooqi is the 2026 recipient of the European Association for the Study of Obesity (EASO) - Novo Nordisk Foundation (NNF) Obesity Prize for Excellence, for her seminal contributions to understanding the genetic and physiological mechanisms that contribute to the development...


Read more at: How early maternal caloric environment may influence placental development and function
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How early maternal caloric environment may influence placental development and function

12 March 2026

New research led by scientists from the University of Cambridge has uncovered a striking link between a mother’s body mass index (BMI) and the levels of key placental proteins circulating in her blood during early pregnancy. This collaborative study led by Nooria Atta, Professor Stephen O'Rahilly and colleagues from the...


Read more at: Patients regain weight rapidly after stopping weight loss drugs – but still keep off a quarter of weight lost
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Patients regain weight rapidly after stopping weight loss drugs – but still keep off a quarter of weight lost

5 March 2026

Glucagon-like peptide 1 receptor agonists (GLP-1RAs) have emerged as breakthrough agents for weight loss. However, discontinuation is common, and clinical trials have demonstrated significant weight regain following cessation. A systematic review carried out by a team of students at Trinity College and School of Clinical...


Read more at: Real-world performance of the CamAPS FX hybrid closed-loop system in people living with type 1 diabetes
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Real-world performance of the CamAPS FX hybrid closed-loop system in people living with type 1 diabetes

3 March 2026

Researchers in the Hovorka and Boughton groups at the IMS-MRL have carried out a retrospective observational analysis of data from over 35,000 people living with type 1 diabetes across 19 countries who use the CamAPS FX hybrid closed-loop system, in order to evaluate the performance of the system in a ‘real-world’ setting...