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The Institute of Metabolic Science-Metabolic Research Laboratories (IMS-MRL) and its embedded Medical Research Council (MRC) Metabolic Diseases Unit investigate the mechanisms through which metabolic health is maintained and how this is disturbed in disease. We seek to use that knowledge to aid better treatment and prevention of obesity, Type 2 diabetes and related endocrine and metabolic diseases.
IMS-MRL research groups encompass skills in genetics, cell biology, cell signalling, neuroendocrinology, bioenergetics, human and animal physiology, experimental medicine and clinical trials.
Latest news
5 March 2026
Glucagon-like peptide 1 receptor agonists (GLP-1RAs) have emerged as breakthrough agents for weight loss. However, discontinuation is common, and clinical trials have demonstrated significant weight regain following cessation. A systematic review carried out by a team of students at Trinity College and School of Clinical...
3 March 2026
Researchers in the Hovorka and Boughton groups at the IMS-MRL have carried out a retrospective observational analysis of data from over 35,000 people living with type 1 diabetes across 19 countries who use the CamAPS FX hybrid closed-loop system, in order to evaluate the performance of the system in a ‘real-world’ setting...
Marie Sklodowska-Curie Postdoctoral Fellowship awarded to Dr Manon Barbot
24 February 2026
Congratulations to Dr Manon Barbot from the Blouet group who has been awarded a Marie Sklodowska-Curie Postdoctoral Fellowship from the European Commission. Her project entitled ' DVC-GATE: DVC Gatekeeping of Incretin Receptor Agonist Therapies' focuses on brainstem barrier mechanisms controlling access of anti-obesity...
