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Institute of Metabolic Science

Metabolic Research Laboratories

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The Institute of Metabolic Science-Metabolic Research Laboratories (IMS-MRL) and its embedded Medical Research Council (MRC) Metabolic Diseases Unit investigate the mechanisms through which metabolic health is maintained and how this is disturbed in disease. We seek to use that knowledge to aid better treatment and prevention of obesity, Type 2 diabetes and related endocrine and metabolic diseases.

IMS-MRL research groups encompass skills in genetics, cell biology, cell signalling, neuroendocrinology, bioenergetics, human and animal physiology, experimental medicine and clinical trials.

Read more at: Our Research
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Our Research

Research at the Institute of Metabolic Science-Metabolic Research Laboratories is dedicated to understanding the mechanisms responsible for obesity and related metabolic diseases, with the specific aims of undertaking high quality basic science and clinical research to improve understanding of, and...


Read more at: Study with us
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Study with us

The Institute of Metabolic Science offers a world class environment for research in obesity, diabetes and cardiovascular disease. Training graduate students for a scientific career is a priority at the IMS-MRL. We have a mixture of both basic science students and clinical trainees and aim to...



Latest news

Rare gene variants reveal a new Prader-Willi-like Syndrome behind childhood obesity

2 July 2025

Researchers from the Yeo group at the IMS-MRL including Giles Yeo, Anna-Maria Siegert, and Loraine Tung , working in collaboration with Institut Pasteur de Lille, Imperial College London and research teams in Pakistan, have identified that mutations in the SREK1 gene result in severe early onset obesity and share features...

Professor Sir Stephen O'Rahilly jointly shares the Distinguished Service Award at the 2nd Lund Spring Symposium

22 May 2025

Congratulations to Professor Stephen O'Rahilly from the IMS-MRL and Professor Jens Juul Holst (Copenhagen University, Denmark) who are joint winners of the Distinguished Service Award presented at the 2nd Lund Spring Symposium taking place in Sweden this week. Professor Holst co-discovered the hormone glucagon-like peptide...

Professor Frank Reimann announced as a new Academy of Medical Sciences Fellow

22 May 2025

The Academy of Medical Sciences (AMS) has announced its newly elected biomedical and health scientists to its prestigious Fellowship, and we are delighted that Professor Frank Reimann from the IMS-MRL is included in the list of 54 exceptional researchers. Frank is Professor of Endocrine Signalling and his research lab, in...