The Institute of Metabolic Science-Metabolic Research Laboratories (IMS-MRL) and its embedded Medical Research Council (MRC) Metabolic Diseases Unit investigate the mechanisms through which metabolic health is maintained and how this is disturbed in disease. We seek to use that knowledge to aid better treatment and prevention of obesity, Type 2 diabetes and related endocrine and metabolic diseases.
IMS-MRL research groups encompass skills in genetics, cell biology, cell signalling, neuroendocrinology, bioenergetics, human and animal physiology, experimental medicine and clinical trials.
Latest news
Genetic study shows how poor metabolic health causes premature ageing
29 April 2025
A study led by Dr Alexander Mörseburg* and colleagues at the IMS-MRL and MRC Epidemiology Unit in Cambridge, has used an “ageing clock” with UK Biobank data from 44,435 to show that people with type 2 diabetes and higher BMI were more likely to have a biological age older than their chronological age. As we age, levels of...
Dr Eleanor Raffan announced as a 2025 Springboard awardee by the Academy of Medical Sciences
10 April 2025
Congratulations to one of our Affiliated PIs, Dr. Eleanor Raffan from the IMS-MRL and Department of Physiology, Development and Neurosciences, who has been awarded £125,000 through the Springboard programme from the Academy of Medical Sciences. This grant, alongside mentoring and career development support will allow her...
New review on the GIP receptor and metabolic control
7 April 2025
A new review article by Paula-Peace James-Okoro, PhD student with the Gribble/Reimann group, and colleagues at the IMS-MRL, which was recently published in Frontiers in Endocrinology , explores how the Glucose-dependent insulinotropic polypeptide receptor (GIPR) contributes to the regulation of appetite, body weight, and...
