Professor Mark Evans

Mathieu C, Wych J, Hendriks EJ, Van Ryckeghem L, Tree T, Chmura P, Möller C, Casteels K, Danne T, Reschke F, Smigoc Schweiger D, Battelino T, Johannesen J, Rami-Merhar B, Pieber T, De Block C, Evans M, Hilbrands R, Bosi E, Willemsen R, Basu S, Pulkkinen M-A, Knip M, Cnop M, Niemöller E, Peakman M, Wilhelm-Benartzi C, Gillespie D, Overbergh L, Mander AP, Marcovecchio ML on behalf of INNODIA. An adaptive dose-ranging trial to identify the Minimum Effective Low Dose of Anti-human Thymocyte Globulin (MELD-ATG) in people 5 to 25 years old with new onset stage 3 type 1 diabetes.  Lancet. 2025 Sep 27;406(10510):1375-1388. doi: 10.1016/S0140-6736(25)01674-5. Epub 2025 Sep 18. PMID: 40976248.

Forteath C, Merchant HJ, Kocherry C, Murdoch CE, Kerr J, Gallagher JR, Evans ML, Thorens B, Pedersen-Bjergaard U, de Galan BE, McCrimmon RJ, McNeilly AD on behalf of HypoRESOLVE Consortium. Recurrent hypoglycaemia promotes cardiomyopathy and cardiac vulnerability in a rodent model of type 1 diabetes. Accepted Diabetologia Aug 2025

Goodman J, Schain M, Di Stefano G, Lupson V, Horn T, Hill M, Manavaki R, Fryer TD, Bumanlag-Amis E, Jalaludeen N, Jermutus L, Johansson E, Heurling K, Haraldsson H, Evans M, Cheriyan J, Johansson L, Ambery P, Wilkinson IB. Intravenous exenatide and glucagon co-infusion increases myocardial glucose uptake and markers of diastolic dysfunction in overweight adults with type 2 diabetes. Sci Rep. 2025 Jul 1;15(1):21404. doi: 10.1038/s41598-025-04559-3. PMID: 40593987; PMCID: PMC12217732

Liarakos AL, Crabtree TSJ, Griffin TP, Hussain S, Gallen G, Elliott J, Furlong N, Narendran P, Thabit H, Leelarathna L, Evans ML, Philbey C, Cranston I, Kamaruddin S, Htike ZZ, Sawyer L, Curtis L, Kirby J, Douek I, Chakera AJ, Saunders S, Bickerton A, Bawlchhim Z, Soar C, Wadham C, Williams C, Levitt M, Weston P, Kar P, Ryder REJ, Lumb A, Choudhary P, Wilmot EG. Hybrid Closed-Loop Therapy in Adults with Type 1 Diabetes in England: Long-Term Outcomes from a Real-World Observational Study. Diabetes Technol Ther. 2025 May 30. doi: 10.1089/dia.2025.0165. Epub ahead of print. PMID: 40445741.

Hendriks AEJ, Marcovecchio ML, Evans ML, Barker P, Burling K, Overbergh L, Mathieu C on behalf of the INNODIA consortium. Early detection of change in beta-cell function using frequently at home measured dried blood spot C-peptide levels in newly diagnosed type 1 diabetes. Accepted Diab Care April 2025

Wilmot E, Ajjan RA, Cheah Y, Cranston IC, Elliott R, Evans M, Iqbal A, Kamaruddin S, Barnard-Kelly K, Lumb A, Min T, Moore P, Narendran P, Neupane S, Rayman G, Sathyapalan T, Thabit H, Yates T, Leelarathna L. Impact of real-time glucose monitoring using FreeStyle Libre 3 on glycaemia in type 2 diabetes managed with basal insulin plus SGLT2 inhibitor and/or GLP-1 agonist- the FreeDM2 randomised controlled trial protocol. BMJ Open 2025;15:e090154. doi: 10.1136/bmjopen-2024-090154

Dlugatch R, Rankin D, Evans M, Oliver N, Ng M, Lawton J. Improving access to diabetes technologies in children and young people with type 1 diabetes: healthcare professionals’ perspectives and views Diabet Med. 2025 Jul;42(7):e70058. doi: 10.1111/dme.70058. Epub 2025 Apr 25. PMID: 40279481; PMCID: PMC7617667.

Dlugatch R, Rankin D, Evans M, Oliver N, Ng M, Lawton J Understanding inequities in access to diabetes technologies in children and young people with type 1 diabetes: qualitative study of healthcare professionals’ perspectives and views. Diabet Med. 2025 Apr;42(4):e15486. doi: 10.1111/dme.15486. Epub 2024 Nov 29. PMID: 39611761; PMCID: PMC11929559.

Royston C, Boughton C, Nwokolo M, Lakshman R, Hartnell S, Wilinska ME, Ware J, Allen JM, Thabit H, Mader JK, Bally L, Leelarathna L, Evans ML, Hovorka R. Impact of Ultra-Rapid Insulin on Boost and Ease-Off in the Cambridge Hybrid Closed-Loop System for Individuals with Type 1 Diabetes. J Diabetes Sci Technol. 2024 Oct 18:19322968241289963. doi: 10.1177/19322968241289963. Epub ahead of print. PMID: 39422158.

Divilly P, Martine-Edith G, Zaremba N, Soholm U, Mahmoudi Z, Cigler M, Ali N, Abbink EJ, Brosen J, de Galan B, Pedersen-Bjergaard U, Vaag AA, McCrimmon RJ, Renard E, Heller S, Evans M, Mader JK, Amiel SA, Pouwer F, Choudhary P; Hypo-RESOLVE Consortium. Relationship Between Sensor-Detected Hypoglycemia and Patient-Reported Hypoglycemia in People with Type 1 and Insulin-Treated Type 2 Diabetes: The Hypo-METRICS Study. Diabetes Care. 2024 Oct 1;47(10):1769-1777. doi: 10.2337/dc23-2332. PMID: 39207738; PMCID: PMC11417281.

Soholm U, Broadley M, Zaremba N, Divilly P, Baumann PM, Mahmoudi Z, Martine-Edith G, Mader JK, Cigler M, Brosen JMB, Vaag A, Heller S, Pedersen-Bjergaard U, McCrimmon RJ, Renard E, Evans M, de Galan B, Abbink E, Amiel SA, Hendrieckx C, Speight J, Choudhary P, Pouwer F; Hypo-RESOLVE consortium. The impact of hypoglycaemia on daily functioning among adults with diabetes: a prospective observational study using the Hypo-METRICS app. Diabetologia. 2024 Oct;67(10):2160-2174. doi: 10.1007/s00125-024-06233-1. Epub 2024 Jul 30. PMID: 39080044; PMCID: PMC11447150.

Zaremba N, Martine-Edith G, Divilly P, Soholm U, Broadley M, Ali N, Abbink EJ, de Galan B, Cigler M, Mader JK, Brosen J, Pedersen-Bjergaard U, Vaag A, Evans M, Renard E, McCrimmon RJ, Heller S, Speight J, Pouwer F, Amiel SA, Choudhary P; Hypo‐RESOLVE Consortium. Associations of clinical, psychological, and sociodemographic characteristics and ecological momentary assessment completion in the 10-week Hypo-METRICS study: Hypoglycaemia MEasurements ThResholds and ImpaCtS. Diabet Med. 2024 Aug;41(8):e15345. doi: 10.1111/dme.15345. Epub 2024 May 17. PMID: 38760977.

Svensson CH, Fabricius TW, Verhulst CEM, Kristensen PL, Tack CJ, Heller SR, Amiel SA, McCrimmon RJ, Evans M, Holst JJ, de Galan BE, Pedersen-Bjergaard U; Hypo‐RESOLVE consortium. Association between recent exposure to continuous glucose monitoring-recorded hypoglycaemia and counterregulatory and symptom responses to subsequent controlled hypoglycaemia in people with type 1 diabetes. Diabetes Obes Metab. 2024 Aug;26(8):3213-3222. doi: 10.1111/dom.15649. Epub 2024 May 22. PMID: 38774963.

Kadiyala N, Wilinska ME, Daly AB, Nwokolo M, Lakshman R, Hartnell S, Ware J, Allen JM, Cezar A, Evans ML, Hovorka R, Boughton CK. Hypoglycemia and Hyperglycemia According to Type of Diabetes: Observations During Fully Closed-Loop Insulin Delivery in Adults With Type 1 and Type 2 Diabetes. J Diabetes Sci Technol. 2024 Apr 13:19322968241242803. doi: 10.1177/19322968241242803. Epub ahead of print. PMID: 38613227.

Martine-Edith G, Zaremba N, Divilly P, Søholm U, Broadley M, Baumann PM, Mahmoudi Z, Gomes M,  Ali N, Abbink EJ, Galan BE, Brøsen J, Pedersen-Bjergaard U, Vaag AA, McCrimmon RJ, Renard E, Heller S, Evans M, Cigler M, Mader JK, Amiel SA, Speight J, Pouwer F, Choudhary P for the Hypo-RESOLVE Consortium. Associations between hypoglycaemia awareness status and symptoms of hypoglycaemia among adults with type 1 and insulin-treated type 2 diabetes using the Hypo-METRICS app. Diab Technol Ther 2024 doi: 10.1089/dia.2023.0596 Online ahead of print.

Marcovecchio ML, Hendriks AEJ, Delfin C, Battelino T, Danne T, Evans ML, Johannesen J, Kaur S, Knip M, Overbergh L, Pociot F, Todd J, Van der Schueren B, Wicker LS, Peakman M, Mathieu C on behalf of the INNODIA consortium. The INNODIA Type 1 Diabetes Natural History Study – a European cohort of newly diagnosed children, adolescents and adults. Diabetologia Online Mar 22 2024. doi: 10.1007/s00125-024-06124-5 Online ahead of print. PMID: 38517484

Haliloglu B, Boughton CK, Lakshman R, Ware J, Nwokolo M, Thabit H, Mader JK, Bally L, Leelarathna L, Wilinska ME, Allen JM, Hartnell S, Evans ML, Hovorka R Postprandial Glucose Excursions with Ultra-Rapid Insulin Analogues in Hybrid Closed-Loop Therapy for Adults with Type 1 Diabetes. Diab Technol Ther 2024 Feb 27. doi: 10.1089/dia.2023.0509 Online ahead of print. PMID: 38315506

Martine-Edith G, Divilly P, Zaremba N, Søholm U, Broadley M, Baumann PM, Mahmoudi Z, Gomes M,  Ali N, Abbink EJ, Galan BE, Brøsen J, Pedersen-Bjergaard U, Vaag AA, McCrimmon RJ, Renard E, Heller S, Evans M, Cigler M, Mader JK, Speight J, Pouwer F, Amiel SA, Choudhary P for the Hypo-RESOLVE Consortium A comparison of the rates of clock-based nocturnal hypoglycemia and hypoglycemia whilst asleep among people living with diabetes: findings from the Hypo-METRICS study. Diab Technol Ther 2024 Apr 17. doi: 10.1089/dia.2023.0522 Online ahead of print. PMID: 38386436

Fabricius TW; Verhulst CEM; Kristensen PL; Holst JJ; Tack CJ; McCrimmon RJ; Heller SR; Evans ML; de Galan BE; Pedersen-Bjergaard U. Counterregulatory hormone and symptom responses to hypoglycaemia in people with type 1 diabetes, insulin-treated type 2 diabetes or without diabetes – the Hypo-RESOLVE hypoglycaemic clamp study. Acta Diabetologica 2024 May;61(5):623-633. doi: 10.1007/s00592-024-02239-8. Epub 2024 Feb 20 PMID: 38376580

Thabit H, Boughton C, Mubita W, Rubio J, Allen S, Heugh R, Mader JK, Narendran P, Evans M, Leelarathna L, Wilinska ME, Fullwood C, Garratt C, Hovorka R, Rutter MK. Impact of hybrid closed-loop insulin delivery on cardiac rhythm in older adults with type 1 diabetes: A post hoc analysis of trial data. Diabetes Obes Metab. 2024 Mar;26(3):1105-1109. doi: 10.1111/dom.15366. Epub 2023 Nov 20. PMID: 37984425; PMCID: PMC10872628.

Lakshman R, Hartnell S, Ware J, Allen JM, Wilinska ME, Nwokolo M, Evans ML, Hovorka R, Boughton CK. Lived Experience of Fully Closed-Loop Insulin Delivery in Adults with Type 1 Diabetes. Diabetes Technol Ther. 2024 Apr;26(4):211-221. doi: 10.1089/dia.2023.0394. Epub 2024 Feb 28. PMID: 38426909; PMCID: PMC10979660.

Leelarathna L, Sutton CJ, Evans ML, Neupane S, Rayman G, Lumley S, Cranston I, Narendran P, Krishan A, Taxiarchi VP, Barnard-Kelly K, Elliott RA, Burns M, Camm M, Thabit H, Wilmot EG; FLASH-UK Trial Study Group. Intermittently scanned continuous glucose monitoring in adults with type 1 diabetes: A subgroup analysis from the FLASH-UK study. Diabet Med. 2024 Mar;41(3):e15249. doi: 10.1111/dme.15249. Epub 2023 Nov 5. PMID: 37897112.