Current work and interests
The overall aim of my research is to understand the mechanisms through which the brain regulates our body’s blood glucose levels and assess the therapeutic potential of brain-specific manipulations for the treatment of metabolic disorders such as diabetes.
Background and experience
I became interested in how the brain regulates physiological processes (and how it goes wrong!) during my undergraduate degree in Biomedical Science at Queen’s University Belfast when I was accepted onto the International Undergraduate Research Programme at the University of Reno Nevada School of Medicine and spent a year in the lab of Prof. Yumei Feng studying mechanisms underpinning neurogenic hypertension. Following the completion of my undergraduate degree in 2017, I joined the IMS-MRL on the Wellcome Trust PhD Programme (1+3) in Cardiovascular and Metabolic Disease and obtained my PhD in the Blouet lab in 2022. My PhD research focussed on the regulation and function of oligodendrocyte plasticity in a brain region known as the median eminence using in vivo models and molecular biology techniques.
Working at the IMS-MRL
I investigate how discrete manipulations of hypothalamic neurocircuitry affect metabolism by performing functional assessments in behaving rodents. Coupled with downstream histological, cellular, and molecular analyses of rodent tissues, this multidisciplinary approach allows me to characterise the contribution of specific cell types or pathways to the central regulation of energy balance and glucose homeostasis.
CNS 2022: New Horizons Poster Prize (Annual Cambridge Neuroscience Conference, 2022)
BSN-SNE Poster Prize (4th BSN-SNE joint meeting of Neuroendocrinology, 2021)
|Median eminence myelin continuously turns over in adult mice (2022). Buller S, Kohnke S, Hansford R, Shimizu T, Richardson WD, Blouet C. BioRxiv, doi: https://doi.org/10.1101/2022.11.16.516753|
Nutritional regulation of oligodendrocyte differentiation regulates perineuronal net remodeling in the median eminence (2021). Kohnke S, Buller S, Nuzzaci D, Ridley K, Lam B, Pivonkova H, Bentsen MA, Alonge KM, Zhao C, Tadross J, Holmqvist S, Shimizo T, Hathaway H, Li H, Macklin W, Schwartz MW, Richardson WD, Yeo GSH, Franklin RJM, Karadottir RT, Rowitch DH, Blouet C. Cell Reports, PMID: 34260928.
MC3R links nutritional state to childhood growth and the timing of puberty (2021). Lam BYH, Williamson A, Finer S, Day F, Tadross JA, Gonçalves Soares A, Wade K, Sweeney P, Bedenbaugh MN, Porter DT, Melvin A, Ellacott KLJ, Lippert RN, Buller S, Rosmaninho-Salgado J, Dowsett GKC, Ridley KE, Xu Z, Cimino I, Rimmington D, Rainbow K, Duckett K, Holmqvist S, Khan A, Dai X, Bochukova EG, Genes & Health Research Team, Trembath RC, Martin HC, Coll AP, Rowitch DH, Wareham NJ, van Heel DA, Timpson N, Simerly RB, Ong KK, Cone, RD, Langenberg C, Perry JRB, Yeo GSH, O’Rahilly S. Nature, PMID: 34732894
Maternal obesity causes fetal hypothalamic insulin resistance and disrupts development of hypothalamic feeding pathways (2020). Dearden L, Buller S, Furigo IC, Fernandez-Twinn DS, Ozanne SE. Mol Metab. PMID: 32919096