• The comprehensive analysis of metabolites (metabolomics) and lipids (lipidomics) in biological samples.
• The development and application of LC-MS methods for the measurement of small molecules.
• Lipidomics and metabolomics data analysis and interpretation.
• Development of approaches for novel samples types for lipid and metabolite profiling.
• Providing training in lipidomics and metabolomics

Team achievements

• The development of single cell lipidomics
• Comprehensive quantitative lipid profiling of plasma and tissue samples.
• The development of Lipid Traffic analysis.
• Metformin measurement in plasma and tissue samples.

Recent publications

• Mocciaro G, D’Amore S, Jenkins B, Kay R, Murgia A, Herrera-Marcos LV, Neun S, Sowton AP, Hall Z, Palma-Duran SA, Palasciano G, Reimann F, Murray A, Suppressa P, Sabbà C, Moschetta A, Koulman A, Griffin JL, Vacca M. Lipidomic Approaches to Study HDL Metabolism in Patients with Central Obesity Diagnosed with Metabolic Syndrome. Int J Mol Sci. 2022 Jun 17;23(12):6786.
• Pantaleao LC, Inzani I, Furse S, Loche E, Hufnagel A, Ashmore T, Blackmore HL, Jenkins B, Carpenter AAM, Wilczynska A, Bushell M, Koulman A, Fernandez-Twinn DS & Ozanne SE (2022) Maternal diet-induced obesity during pregnancy alters lipid supply to mouse E18.5 fetuses and changes the cardiac tissue lipidome in a sex-dependent manner. Elife 11: e69078
• Hufnagel A, Fernandez-Twinn DS, Blackmore HL, Ashmore TJ, Heaton RA, Jenkins B. Koulman A, Hargreaves IP, Aiken CE & Ozanne SE (2022) Maternal but not fetoplacental health can be improved by metformin in a murine diet-induced model of maternal obesity and glucose intolerance. J Physiol 600: 903-919.