Congratulations to Fiona Gribble and Frank Reimann who have received a prestigious Wellcome Joint Investigator Award. The five year grant ‘Targeting the gut in metabolic disease,’ will allow the group to investigate the cellular mechanisms of gut hormone secretion in human organoid models, and explore how the gut endocrine axis in humans is affected by nutrition, obesity and metabolic disease. The methods for the organoid work are due to be published in a few weeks, and a new paper describing how they use mass spectrometry to measure multiple gut hormones in parallel in human plasma, forms the basis for studying the effects of nutrition, obesity and metabolic disease on circulating gut hormone levels.