Primary Research Publications
2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | Older
2023
- Annamalai AK, Hemamalini R, Gurnell M. Bilateral enlarged ovarian masses and hypothyroidism. Eur J Intern Med. 2023 Mar 12:S0953-6205(23)00077-8. doi: 10.1016/j.ejim.2023.03.011. PMID:36918319
- Annamalai AK, Srinivasan KG, Gurnell M. Secondary amenorrhoea with absent axillary hair. Eur J Intern Med. 2023 Mar 11:S0953-6205(23)00082-1. doi: 10.1016/j.ejim.2023.03.009. PMID:36914538
- Asami M, Lam BYH, Hoffmann M, Suzuki T, Lu X, Yoshida N, Ma MK, Rainbow K, Gužvić M, VerMilyea MD, Yeo GSH, Klein CA, Perry ACF. A program of successive gene expression in mouse one-cell embryos. Cell Rep. 2023 Jan 31;42(2):112023. doi: 10.1016/j.celrep.2023.112023. PMID:36729835
- Aye CC, Hammond DE, Rodriguez-Cuenca S, Doherty MK, Whitfield PD, Phelan MM, Yang C, Perez-Perez R, Li X, Diaz-Ramos A, Peddinti G, Oresic M, Vidal-Puig A, Zorzano A, Ugalde C, Mora S. CBL/CAP Is Essential for Mitochondria Respiration Complex I Assembly and Bioenergetics Efficiency in Muscle Cells. Int J Mol Sci. 2023 Feb 8;24(4):3399. doi: 10.3390/ijms24043399. PMID:36834818 PMCID:PMC9964740
- Broadaway KA, Yin X, Williamson A, Parsons VA, Wilson EP, Moxley AH, Vadlamudi S, Varshney A, Jackson AU, Ahuja V, Bornstein SR, Corbin LJ, Delgado GE, Dwivedi OP, Silva LF, Frayling TM, Grallert H, Gustafsson S, Hakaste L, Hammar U, Herder C, Herrmann S, Højlund K, Hughes DA, Kleber ME, Lindgren CM, Liu CT, Luan J, Malmberg A, Moissl AP, Morris AP, Perakakis N, Peters A, Petrie JR, Roden M, Schwarz PEH, Sharma S, Silveira A, Strawbridge RJ, Tuomi T, Wood AR, Wu P, Zethelius B, Baldassarre D, Eriksson JG, Fall T, Florez JC, Fritsche A, Gigante B, Hamsten A, Kajantie E, Laakso M, Lahti J, Lawlor DA, Lind L, März W, Meigs JB, Sundström J, Timpson NJ, Wagner R, Walker M, Wareham NJ, Watkins H, Barroso I, O’Rahilly S, Grarup N, Parker SC, Boehnke M, Langenberg C, Wheeler E, Mohlke KL. Loci for insulin processing and secretion provide insight into type 2 diabetes risk. Am J Hum Genet. 2023 Feb 2;110(2):284-299.doi: 10.1016/j.ajhg.2023.01.002. PMID:36693378
- Buller S, Kohnke S, Hansford R, Shimizu T, Richardson WD, Blouet C. Median eminence myelin continuously turns over in adult mice. Mol Metab. 2023 Feb 3;101690. doi: 10.1016/j.molmet.2023.101690. PMID:36739968
- Daly AB, Boughton CK, Nwokolo M, Hartnell S, Wilinska ME, Cezar A, Evans ML, Hovorka R. Fully automated closed-loop insulin delivery in adults with type 2 diabetes: an open-label, single-center, randomized crossover trial. Nat Med. 2023 Jan;29(1):203-208. PMID:36631592
- Dearden L, Ozanne SE. Considerations for designing and analysing inter-generational studies in rodents. Nat Metab. 2023 Jan;5(1):1-4. doi: 10.1038/s42255-022-00721-7. PMID:36609721
- Fazakerley DJ, van Gerwen J, Cooke KC, Duan X, Needham EJ, Díaz-Vegas A, Madsen S, Norris DM, Shun-Shion AS, Krycer JR, Burchfield JG, Yang P, Wade MR, Brozinick JT, James DE, Humphrey SJ. Phosphoproteomics reveals rewiring of the insulin signaling network and multi-nodal defects in insulin resistance. Nat Commun. 2023 Feb 18;14(1):923. doi: 10.1038/s41467-023-36549-2. PMID:36808134 PMCID:PMC9938909
- Fernandes HJR, Kent JP, Bruntraeger M, Bassett AR, Koulman A, Metzakopian E, Snowden SG. Mitochondrial and Endoplasmic Reticulum Stress Trigger Triglyceride Accumulation in Models of Parkinson’s Disease Independent of Mutations in MAPT. Metabolites. 2023 Jan 9;13(1):112.
doi: 10.3390/metabo13010112. PMID:36677037 PMCID:PMC9861589 - Ferrer M, Mourikis N, Davidson EE, Kleeman SO, Zaccaria M, Habel J, Rubino R, Flint TR, Connell CM, Lukey M, White EP, Coll AP, Venkitaraman AR, Janowitz T. Ketogenic diet promotes tumor ferroptosis but induces relative corticosterone deficiency that accelerates cachexia. bioRxiv. 2023 Feb 18:2023.02.17.528937. doi: 10.1101/2023.02.17.528937. PMID:36824830 PMCID:PMC9949105
- Furse S, Morgan HL, Koulman A, Watkins AJ. Characterisation of the Paternal Influence on Intergenerational Offspring Cardiac and Brain Lipid Homeostasis in Mice. Int J Mol Sci. 2023 Jan 17;24(3):1814. doi: 10.3390/ijms24031814. PMID:36768137 PMCID:PMC9916277
- Ganeva I, Lim K, Boulanger J, Hoffmann PC, Muriel O, Borgeaud AC, Hagen WJH, Savage DB, Kukulski W. The architecture of Cidec-mediated interfaces between lipid droplets. Cell Rep. 2023 Feb 15;42(2):112107. doi: 10.1016/j.celrep.2023.112107. PMID:36800289 PMCID:PMC9989828
- George AL, Foreman RE, Sayda MH, Reimann F, Gribble FM, Kay RG. Rapid and Quantitative Enrichment of Peptides from Plasma for Mass Spectrometric Analysis. Methods Mol Biol. 2023;2628:477-488. doi: 10.1007/978-1-0716-2978-9_28. PMID:36781802
- Goff LM, Davies K, Zelek WM, Kodosaki E, Hakim O, Lockhart S, O’Rahilly S, Morgan BP. Ethnic differences in complement system biomarkers and their association with metabolic health in men of Black African and White European ethnicity. Clin Exp Immunol. 2023 Feb 1;uxad011.doi: 10.1093/cei/uxad011. PMID:36722378
- Hayashi M, Kaye JA, Douglas ER, Joshi NR, Gribble FM, Reimann F, Liberles SD. Enteroendocrine cell lineages that differentially control feeding and gut motility. Elife. 2023 Feb 22;12:e78512.doi: 10.7554/eLife.78512. PMID:36810133
- Jones KS, Parkington DA, Bourassa MW, Cerami C, Koulman A. Protocol and application of basal erythrocyte transketolase activity to improve assessment of thiamine status. Ann N Y Acad Sci. 2023 Jan 31. doi:10.1111/nyas.14962. PMID:36719404
- Justulin LA, Zambrano E, Ong TP, Ozanne SE. Editorial: Early Life Epigenetic Programming of Health and Disease through DOHaD Perspective. Front Cell Dev Biol. 2023 Feb 10;11:1139283. doi: 10.3389/fcell.2023.1139283. PMID:36846583 PMCID:PMC9950751
- Karusheva Y, Petry CJ, Yasara N, Kottahachchi D, Premawardhena A, Barker P, Burling K, Sattar N, Welsh P, Mettananda S, O’Rahilly S. Association of GDF15 levels with body mass index and endocrine status in β-thalassaemia. Clin Endocrinol (Oxf). 2023 Feb 21. doi: 10.1111/cen.14897. PMID:36806122
- Krutkyte G, Roos J, Schuerch D, Czerlau C, Wilinska ME, Wuethrich PY, Herzig D, Hovorka R, Vogt AP, Gloor B, Bally L. Fully Closed-Loop Insulin Delivery in Patients Undergoing Pancreatic Surgery. Diabetes Technol Ther. 2023 Mar;25(3):206-211. doi: 10.1089/dia.2022.0400. PMID:36449375 PMCID:PMC9983122
- Layard Horsfall H, Lawrence A, Venkatesh A, Loh RTS, Jayapalan R, Koulouri O, Sharma R, Santarius T, Gurnell M, Dorward N, Mannion R, Marcus HJ, Kolias AG. Reported outcomes in transsphenoidal surgery for pituitary adenomas: a systematic review. Pituitary. 2023 Mar 2.
doi: 10.1007/s11102-023-01303-w. PMID:36862265 - Knolle F, Sterner E, Moutoussis M, Adams RA, Griffin JD, Haarsma J, Taverne H, Goodyer IM, Fletcher PC, Murray GK; NSPN Consortium. Action selection in early stages of psychosis: an active inference approach. J Psychiatry Neurosci. 2023 Feb 21;48(1):E78-E89. doi: 10.1503/jpn.220141. Print 2023 Jan-Feb. PMID:36810306 PMCID:PMC9949875
- Kusinski LC, Meek CL. Big babies, small babies: metformin exposure in pregnancy. Lancet Diabetes Endocrinol. 2023 Feb 3;S2213-8587(23)00034-7.
doi: 10.1016/S2213-8587(23)00034-7. PMID:36746162 - Lakshman R, Daly AB, Nwokolo M, Hartnell S, Wilinska ME, Cezar A, Evans ML, Hovorka R, Boughton CK. Insulin Requirements Over Eight Weeks of Fully Closed-Loop Insulin Delivery in Adults With Type 2 Diabetes. J Diabetes Sci Technol. 2023 Mar 13:19322968231159412. doi: 10.1177/19322968231159412. PMID:36912020
- Lee E, Korf H, Vidal-Puig A. An adipocentric perspective on the development and progression of non-alcoholic fatty liver disease. J Hepatol. 2023 Feb 3;S0168-8278(23)00077-6. doi: 10.1016/j.jhep.2023.01.024. PMID:36740049
- Mann JP, Duan X, Patel S, Tábara LC, Scurria F, Alvarez-Guaita A, Haider A, Luijten I, Page M, Protasoni M, Lim K, Virtue S, O’Rahilly S, Armstrong M, Prudent J, Semple RK, Savage DB. A mouse model of human mitofusin 2-related lipodystrophy exhibits adipose-specific mitochondrial stress and reduced leptin secretion. Elife. 2023 Feb 1;12:e82283.doi: 10.7554/eLife.82283. PMID:36722855
- Pereira C, Stalder D, Anderson GSF, Shun-Shion AS, Houghton J, Antrobus R, Chapman MA, Fazakerley DJ, Gershlick DC. The exocyst complex is an essential component of the mammalian constitutive secretory pathway. J Cell Biol. 2023 May 1;222(5):e202205137. doi: 10.1083/jcb.202205137. Epub 2023 Mar 15. PMID:36920342
- Rubino F, Batterham RL, Koch M, Mingrone G, le Roux CW, Farooqi IS, Farpour-Lambert N, Gregg EW, Cummings DE. Lancet Diabetes & Endocrinology Commission on the Definition and Diagnosis of Clinical Obesity. Lancet Diabetes Endocrinol. 2023 Mar 3:S2213-8587(23)00058-X. doi: 10.1016/S2213-8587(23)00058-X. PMID:36878238
- Santos A, Delgado TC, Marques V, Moncayo CR, Alonso C, Vidal-Puig A, Hall Z, Martínez-Chantar ML, Rodrigues CMP. Spatial metabolomics and its application in the liver. Hepatology. 2023 Feb 27. doi: 10.1097/HEP.0000000000000341. PMID:36811413
- Savage DB. Perilipin 1 Antibodies in Patients With Acquired Generalized Lipodystrophy. Diabetes. 2023 Jan 1;72(1):16-18. doi: 10.2337/dbi22-0022. PMID:36538601
- Talbot F, Feetham CH, Mokrosiński J, Lawler K, Keogh JM, Henning E, Mendes de Oliveira E, Ayinampudi V, Saeed S, Bonnefond A, Arslan M, Yeo GSH, Froguel P, Bechtold DA, Adamson A, Humphreys N, Barroso I, Luckman SM, Farooqi IS. A rare human variant that disrupts GPR10 signalling causes weight gain in mice. Nat Commun. 2023 Mar 15;14(1):1450. doi: 10.1038/s41467-023-36966-3. PMID:36922513 PMCID:PMC10017677
- Tsang A, Blouet C. A pipeline for identification and validation of brain targets for weight loss. Nat Rev Endocrinol. 2023 Jan 25. doi: 10.1038/s41574-023-00803-w. PMID:36697769 PMCID:PMC9873557
- Vernardis SI, Demichev V, Lemke O, Grüning NM, Messner C, White M, Pietzner M, Peluso A, Collet TH, Henning E, Gille C, Campbell A, Hayward C, Porteous DJ, Marioni RE, Mülleder M, Zelezniak A, Wareham NJ, Langenberg C, Farooqi IS, Ralser M. The impact of acute nutritional interventions on the plasma proteome. J Clin Endocrinol Metab. 2023 Jan 20;dgad031. doi: 10.1210/clinem/dgad031. PMID:36658456
- Wagner S, Brierley DI, Leeson-Payne A, Jiang W, Chianese R, Lam BYH, Dowsett GKC, Cristiano C, Lyons D, Reimann F, Gribble FM, Martinez de Morentin PB, Yeo GSH, Trapp S, Heisler LK. Obesity medication lorcaserin activates brainstem GLP-1 neurons to reduce food intake and augments GLP-1 receptor agonist induced appetite suppression. Mol Metab. 2023 Feb;68:101665. doi: 10.1016/j.molmet.2022.101665. PMID:36592795 PMCID:PMC9841057
- Watson L, Cole TJ, Lyons G, Georgiou C, Worsley J, Carr K, Murgatroyd P, Moran C, Chatterjee K, Venables M. Centile reference chart for resting metabolic rate through the life course. Arch Dis Child. 2023 Mar 2;archdischild-2022-325249. doi: 10.1136/archdischild-2022-325249. PMID:36863849
- Wu Q, Wu J, Karim K, Chen X, Wang T, Iwama S, Carobbio S, Keen P, Vidal-Puig A, Kotter MR, Bassett A. Massively parallel characterization of CRISPR activator efficacy in human induced pluripotent stem cells and neurons. Mol Cell. 2023 Mar 3:S1097-2765(23)00114-4. doi: 10.1016/j.molcel.2023.02.011. PMID:36917981
2022
- Andrews PW, Barbaric I, Benvenisty N, Draper JS, Ludwig T, Merkle FT, Sato Y, Spits C, Stacey GN, Wang H, Pera MF. The consequences of recurrent genetic and epigenetic variants in human pluripotent stem cells. Cell Stem Cell. 2022 Dec 1;29(12):1624-1636. doi: 10.1016/j.stem.2022.11.006. PMID:36459966
- Annamalai AK, Gurnell M. Black urine-alkaptonuria. QJM. 2022 Jun 7;115(6):397-398. doi: 10.1093/qjmed/hcac098. PMID:35394539
- Annamalai AK, Prajna VN, Chowdhury G, Santhi R, Kannan M, Vedantham S, Gurnell M. Wilson Disease: Never Too Late. Am J Med. 2022 May 14:S0002-9343(22)00362-X. doi: 10.1016/j.amjmed.2022.04.025. PMID:35580721
- Arima H, Bichet DG, Cheetham T, Christ-Crain M, Drummond J, Gurnell M, Levy M, McCormack A, Newell-Price J, Verbalis JG, Wass J, Cooper D. Changing the name of diabetes insipidus. Pituitary. 2022 Dec;25(6):777-779. doi: 10.1007/s11102-022-01276-2. PMID:36334185
- Arima H, Cheetham T, Christ-Crain M, Cooper DL, Drummond JB, Gurnell M, Levy M, McCormack A, Newell-Price JD, Verbalis JG, Wass J. Changing the name of diabetes insipidus: a position statement of the working group to consider renaming diabetes insipidus. Arch Endocrinol Metab. 2022 Oct 11:2359-3997000000528. doi: 10.20945/2359-3997000000528. PMID:36219203
- Arima H, Cheetham T, Christ-Crain M, Cooper D, Drummond J, Gurnell M, Levy M, McCormack A, Newell-Price J, Verbalis JG, Wass J; Working Group for Renaming Diabetes Insipidus. Changing the Name of Diabetes Insipidus: A Position Statement of the Working Group for Renaming Diabetes Insipidus. J Clin Endocrinol Metab. 2022 Nov 9:dgac547. doi: 10.1210/clinem/dgac547. PMID:36355385
- Arima H, Cheetham T, Christ-Crain M, Cooper DL, Drummond JB, Gurnell M, Levy M, McCormack A, Newell-Price JD, Verbalis JG, Wass J. Changing the Name of Diabetes Insipidus: A Position Statement of the Working Group to Consider Renaming Diabetes Insipidus. Horm Res Paediatr. 2022 Sep 30:1-3. doi: 10.1159/000527139. PMID:36183693
- Arima H, Cheetham T, Christ-Crain M, Cooper D, Drummond J, Gurnell M, Levy M, McCormack A, Newell-Price J, Verbalis JG, Wass J. Changing the name of diabetes insipidus: a position statement of the working group to consider renaming diabetes insipidus. Clin Endocrinol (Oxf). 2022 Aug 28. doi: 10.1111/cen.14819. PMID:36030512
- Aye ILMH, Gong S, Avellino G, Barbagallo R, Gaccioli F, Jenkins BJ, Koulman A, Murray AJ, Stephen Charnock-Jones D, Smith GCS. Placental sex-dependent spermine synthesis regulates trophoblast gene expression through acetyl-coA metabolism and histone acetylation. Commun Biol. 2022 Jun 15;5(1):586. doi: 10.1038/s42003-022-03530-6. PMID:35705689 PMCID:PMC9200719
- Bakker LEH, Verstegen MJT, Ghariq E, Verbist BM, Schutte PJ, Bashari WA, Kruit MC, Pereira AM, Gurnell M, Biermasz NR, van Furth WR, Bouda LMPA. Implementation of functional imaging using 11 C-methionine PET-CT co-registered with MRI for advanced surgical planning and decision making in prolactinoma surgery. Pituitary. 2022 May 26. doi: 10.1007/s11102-022-01230-2. PMID:35616762
- Bashari WA, Gillett D, MacFarlane J, Powlson AS, Kolias AG, Mannion R, Scoffings DJ, Mendichovszky IA, Jones J, Cheow HK, Koulouri O, Gurnell M. Modern imaging in Cushing’s disease. Pituitary. 2022 Jun 6. doi: 10.1007/s11102-022-01236-w. PMID:35666391
- Bashari WA, van der Meulen M, MacFarlane J, Gillett D, Senanayake R, Serban L, Powlson AS, Brooke AM, Scoffings DJ, Jones J, O’Donovan DG, Tysome J, Santarius T, Donnelly N, Boros I, Aigbirhio F, Jefferies S, Cheow HK, Mendichovszky IA, Kolias AG, Mannion R, Koulouri O, Gurnell M. 11 C-methionine PET aids localization of microprolactinomas in patients with intolerance or resistance to dopamine agonist therapy. Pituitary. 2022 May 24. doi: 10.1007/s11102-022-01229-9. PMID:35608811
- Bethlehem RAI, Seidlitz J, White SR, Vogel JW, Anderson KM, Adamson C, Adler S, Alexopoulos GS, Anagnostou E, Areces-Gonzalez A, Astle DE, Auyeung B, Ayub M, Bae J, Ball G, Baron-Cohen S, Beare R, Bedford SA, Benegal V, Beyer F, Blangero J, Blesa Cábez M, Boardman JP, Borzage M, Bosch-Bayard JF, Bourke N, Calhoun VD, Chakravarty MM, Chen C, Chertavian C, Chetelat G, Chong YS, Cole JH, Corvin A, Costantino M, Courchesne E, Crivello F, Cropley VL, Crosbie J, Crossley N, Delarue M, Delorme R, Desrivieres S, Devenyi GA, Di Biase MA, Dolan R, Donald KA, Donohoe G, Dunlop K, Edwards AD, Elison JT, Ellis CT, Elman JA, Eyler L, Fair DA, Feczko E, Fletcher PC, Fonagy P, Franz CE, Galan-Garcia L, Gholipour A, Giedd J, Gilmore JH, Glahn DC, Goodyer IM, Grant PE, Groenewold NA, Gunning FM, Gur RE, Gur RC, Hammill CF, Hansson O, Hedden T, Heinz A, Henson RN, Heuer K, Hoare J, Holla B, Holmes AJ, Holt R, Huang H, Im K, Ipser J, Jack CR Jr, Jackowski AP, Jia T, Johnson KA, Jones PB, Jones DT, Kahn RS, Karlsson H, Karlsson L, Kawashima R, Kelley EA, Kern S, Kim KW, Kitzbichler MG, Kremen WS, Lalonde F, Landeau B, Lee S, Lerch J, Lewis JD, Li J, Liao W, Liston C, Lombardo MV, Lv J, Lynch C, Mallard TT, Marcelis M, Markello RD, Mathias SR, Mazoyer B, McGuire P, Meaney MJ, Mechelli A, Medic N, Misic B, Morgan SE, Mothersill D, Nigg J, Ong MQW, Ortinau C, Ossenkoppele R, Ouyang M, Palaniyappan L, Paly L, Pan PM, Pantelis C, Park MM, Paus T, Pausova Z, Paz-Linares D, Pichet Binette A, Pierce K, Qian X, Qiu J, Qiu A, Raznahan A, Rittman T, Rodrigue A, Rollins CK, Romero-Garcia R, Ronan L, Rosenberg MD, Rowitch DH, Salum GA, Satterthwaite TD, Schaare HL, Schachar RJ, Schultz AP, Schumann G, Schöll M, Sharp D, Shinohara RT, Skoog I, Smyser CD, Sperling RA, Stein DJ, Stolicyn A, Suckling J, Sullivan G, Taki Y, Thyreau B, Toro R, Traut N, Tsvetanov KA, Turk-Browne NB, Tuulari JJ, Tzourio C, Vachon-Presseau É, Valdes-Sosa MJ, Valdes-Sosa PA, Valk SL, van Amelsvoort T, Vandekar SN, Vasung L, Victoria LW, Villeneuve S, Villringer A, Vértes PE, Wagstyl K, Wang YS, Warfield SK, Warrier V, Westman E, Westwater ML, Whalley HC, Witte AV, Yang N, Yeo B, Yun H, Zalesky A, Zar HJ, Zettergren A, Zhou JH, Ziauddeen H, Zugman A, Zuo XN; 3R-BRAIN; AIBL; Alzheimer’s Disease Neuroimaging Initiative; Alzheimer’s Disease Repository Without Borders Investigators; CALM Team; Cam-CAN; CCNP; COBRE; cVEDA; ENIGMA Developmental Brain Age Working Group; Developing Human Connectome Project; FinnBrain; Harvard Aging Brain Study; IMAGEN; KNE96; Mayo Clinic Study of Aging; NSPN; POND; PREVENT-AD Research Group; VETSA, Bullmore ET, Alexander-Bloch AF. Publisher Correction: Brain charts for the human lifespan. Nature. 2022 Oct;610(7931):E6. doi: 10.1038/s41586-022-05300-0. PMID:36151472 PMCID:PMC9556297
- Boughton CK, Allen JM, Ware J, Wilinska ME, Hartnell S, Thankamony A, Randell T, Ghatak A, Besser REJ, Elleri D, Trevelyan N, Campbell FM, Sibayan J, Calhoun P, Bailey R, Dunseath G, Hovorka R; CLOuD Consortium. Closed-Loop Therapy and Preservation of C-Peptide Secretion in Type 1 Diabetes. N Engl J Med. 2022 Sep 8;387(10):882-893. doi: 10.1056/NEJMoa2203496. PMID:36069870
- Boughton CK, Hartnell S, Thabit H, Mubita WM, Draxlbauer K, Poettler T, Wilinska ME, Hood KK, Mader JK, Narendran P, Leelarathna L, Evans ML, Hovorka R. Hybrid closed-loop glucose control compared with sensor augmented pump therapy in older adults with type 1 diabetes: an open-label multicentre, multinational, randomised, crossover study. Lancet Healthy Longev. 2022 Mar;3(3):e135-e142. doi: 10.1016/S2666-7568(22)00005-8. PMID:35359882 PMCID:PMC8967297
- Braithwaite VS, Sharp SJ, Koulman A, Wareham NJ, Rennie KL. An investigation of factors affecting changes in health behaviours during the COVID-19 pandemic in a UK population-based cohort study. Public Health. 2022 Sep 6;212:46-54. doi: 10.1016/j.puhe.2022.08.005. PMID:36209533 PMCID:PMC9444493
- Brown CA, Badger K, Reid MD, Westacott R, Gurnell M, Reed MWR, Chamberlain G, Hatfield E, Sharif A, Sam AH. The influence of candidates’ physical attributes on patient ratings in simulated assessments of clinical practice. Med Teach. 2022 Jul 12:1-6. doi: 10.1080/0142159X.2022.2093177. PMID:35820076
- Cacciottolo TM, Henning E, Keogh JM, Bel Lassen P, Lawler K, Bounds R, Ahmed R, Perdikari A, Mendes de Oliveira E, Smith M, Godfrey EM, Johnson E, Hodson L, Clément K, van der Klaauw AA, Farooqi IS. Obesity due to Steroid Receptor Coactivator-1 deficiency is associated with endocrine and metabolic abnormalities. J Clin Endocrinol Metab. 2022 Feb 8:dgac067. doi: 10.1210/clinem/dgac067. PMID: 35137184
- Calderon RM, Smith CA, Miedzybrodzka EL, Silvaroli JA, Golczak M, Gribble FM, Reimann F, Blaner WS. Intestinal Enteroendocrine Cell Signaling: Retinol-binding Protein 2 and Retinoid Actions. Endocrinology. 2022 Jul 1;163(7):bqac064. doi: 10.1210/endocr/bqac064. PMID:35552670 PMCID:PMC9162388
- Calejman CM, Doxsey WG, Fazakerley DJ, Guertin DA. Integrating adipocyte insulin signaling and metabolism in the multi-omics era. Trends Biochem Sci. 2022 Mar 15:S0968-0004(22)00050-0. doi: 10.1016/j.tibs.2022.02.009. PMID:35304047
- Campbell JE, Beaudry JL, Svendsen B, Baggio LL, Gordon AN, Ussher JR, Wong CK, Gribble FM, D’Alessio DA, Reimann F, Drucker DJ. The GIPR is Predominantly Localized to Non-Adipocyte Cell Types Within White Adipose Tissue. Diabetes. 2022 Feb 22:db211166. doi: 10.2337/db21-1166.PMID: 35192688
- Daniel-Watanabe L, Fletcher PC. Are Fear and Anxiety Truly Distinct? Biol Psychiatry Glob Open Sci. 2021 Oct 6;2(4):341-349. doi: 10.1016/j.bpsgos.2021.09.006. PMID:36324663 PMCID:PMC9616241
- Dennison RA, Griffin SJ, Usher-Smith JA, Fox RA, Aiken CE, Meek CL. “Post-GDM support would be really good for mothers”: A qualitative interview study exploring how to support a healthy diet and physical activity after gestational diabetes. PLoS One. 2022 Jan 21;17(1):eo262852. doi: 10.1371/journal.pone.0262852. PMID:35061856 PMCID:PMC8782419
- Diaz-Vegas A, Norris DM, Jall-Rogg S, Cooke KC, Conway OJ, Shun-Shion AS, Duan X, Potter M, van Gerwen J, Baird HJ, Humphrey SJ, James DE, Fazakerley DJ, Burchfield JG. A high-content endogenous GLUT4 trafficking assay reveals new aspects of adipocyte biology. Life Sci Alliance. 2022 Oct 25;6(1):e202201585. doi: 10.26508/lsa.202201585. PMID:36283703 PMCID:PMC9595207
- Duan X, Norris DM, Humphrey SJ, Yang P, Cooke KC, Bultitude WP, Parker BL, Conway OJ, Burchfield JG, Krycer JR, Brodsky FM, James DE, Fazakerley DJ. Trafficking regulator of GLUT4-1 (TRARG1) is a GSK3 substrate. Biochem J. 2022 Jun 17;479(11):1237-1256. doi: 10.1042/BCJ20220153. PMID:35594055
- Edwards CA, Van Loo-Bouwman CA, Van Diepen JA, Schoemaker MH, Ozanne SE, Venema K, Stanton C, Marinello V, Rueda R, Flourakis M, Gil A, Van der Beek EM. A systematic review of breast milk microbiota composition and the evidence for transfer to and colonisation of the infant gut. Benef Microbes. 2022 Nov 16;13(5):365-381. doi: 10.3920/BM2021.0098. PMID:36377578
- Farooqi IS. Monogenic Obesity Syndromes Provide Insights Into the Hypothalamic Regulation of Appetite and Associated Behaviors. Biol Psychiatry. 2022 May 15;91(10):856-859. doi: 10.1016/j.biopsych.2022.01.018. PMID:35369984
- Fattah M, Boughton CK, Ware J, Allen JM, Hartnell S, Willinska ME, Thankamony A, de Beaufort C, Campbell FM, Fröhlich-Reiterer E, Hofer SE, Kapellen TM, Rami-Merhar B, Ghatak A, Randell TL, Besser REJ, Elleri D, Trevelyan N, Denvir Md L, Davis N, Bally L, Thabit H, Leelarathna L, Evans ML, Mader JK, Hovorka R. Evaluating the Impact of Applying Personal Glucose Targets in a Closed-Loop System for People With Type 1 Diabetes. J Diabetes Sci Technol. 2022 Dec 20;19322968221145184.doi: 10.1177/19322968221145184. PMID:36540007
- Fazakerley DJ, Koumanov F, Holman GD. GLUT4 On the move. Biochem J. 2022 Feb 11;479(3):445-462. doi: 10.1042/BCJ20210073. PMID:35147164 PMCID:PMC8883492
- Fletcher PC, Teufel CR. The Changing Weight of Expectation: How Shifting Priors Underpin Variability in Hallucination Frequency. Biol Psychiatry. 2022 Nov 15;92(10):752-753. doi: 10.1016/j.biopsych.2022.08.027. PMID:36265965
- Foreman RE, Meek CL, Roberts GP, George AL, Reimann F, Gribble FM, Kay RG. LC-MS/MS based detection of circulating proinsulin derived peptides in patients with altered pancreatic beta cell function. J Chromatogr B Analyt Technol Biomed Life Sci. 2022 Oct 5;1211:123482. doi: 10.1016/j.jchromb.2022.123482. PMID: 36242807
- Furse S, Fernandez-Twinn DS, Beeson JH, Chiarugi D, Ozanne SE, Koulman A. A mouse model of gestational diabetes shows dysregulated lipid metabolism post-weaning, after return to euglycaemia. Nutr Diabetes. 2022 Feb 15;12(1):8. doi: 10.1038/s41387-022-00185-4. PMID: 35169132 PMCID: PMC8847647
- Furse S, Koulman A, Ozanne SE, Poston L, White SL, Meek CL. Altered Lipid Metabolism in Obese Women With Gestational Diabetes and Associations With Offspring Adiposity. J Clin Endocrinol Metab. 2022 Jun 16;107(7):e2825-e2832. doi: 10.1210/clinem/dgac206. PMID:35359001
- Furse S, Kusinski LC, Ray A, Glenn-Sansum C, Williams HEL, Koulman A, Meek CL. Relative Abundance of Lipid Metabolites in Spermatozoa across Three Compartments. Int J Mol Sci. 2022 Oct 1;23(19):11655. doi: 10.3390/ijms231911655. PMID:36232961 PMCID:PMC9569887
- Furse S, Virtue S, Snowden SG, Vidal-Puig A, Stevenson PC, Chiarugi D, Koulman A. Dietary PUFAs drive diverse system-level changes in lipid metabolism. Mol Metab. 2022 May;59:101457. doi: 10.1016/j.molmet.2022.101457. PMID:35150907 PMCID:PMC8894240
- Furse S, Watkins AJ, Williams HEL, Snowden SG, Chiarugi D, Koulman A. Paternal nutritional programming of lipid metabolism is propagated through sperm and seminal plasma. Metabolomics. 2022 Feb 10;18(2):13. doi: 10.1007/s11306-022-01869-9. PMID:35141784 PMCID: PMC8828597
- Gardner EJ, Kentistou KA, Stankovic S, Lockhart S, Wheeler E, Day FR, Kerrison ND, Wareham NJ, Langenberg C, O’Rahilly S, Ong KK, Perry JRB. Damaging missense variants in IGF1R implicate a role for IGF-1 resistance in the etiology of type 2 diabetes. Cell Genom. 2022 Dec 14;2(12):None.
doi: 10.1016/j.xgen.2022.100208. PMID:36530175 PMCID:PMC9750938 - Giakoumaki I, Pollock N, Aljuaid T, Sannicandro AJ, Alameddine M, Owen E, Myrtziou I, Ozanne SE, Kanakis I, Goljanek-Whysall K, Vasilaki A. Postnatal Protein Intake as a Determinant of Skeletal Muscle Structure and Function in Mice-A Pilot Study. Int J Mol Sci. 2022 Aug 8;23(15):8815. doi: 10.3390/ijms23158815. PMID:35955948 PMCID:PMC9369224
- Gillett D, Senanayake R, MacFarlane J, van der Meulen M, Koulouri O, Powlson AS, Crawford R, Gillett B, Bird N, Heard S, Kolias A, Mannion R, Aloj L, Mendichovszky IA, Cheow H, Bashari WA, Gurnell M. Localization of TSH-secreting pituitary adenoma using 11C-methionine image subtraction. EJNMMI Res. 2022 May 7;12(1):26. doi: 10.1186/s13550-022-00899-7. PMID:35524902 PMCID:PMC9079199
- Glasgow C, Lau EYC, Aloj L, Harper I, Cheow H, Das T, Berman L, Powlson AS, Bashari W, Challis BG, Marker A, Moyle P, Mohamed I, Schoenmakers N, Broomfield J, Oddy S, Moran C, Gurnell M, Jani P, Masterson L, Fish B, Casey RT. An approach to a patient with primary hyperparathyroidism and a suspected ectopic parathyroid adenoma. J Clin Endocrinol Metab. 2022 Feb 12;dgac024. doi:10.1210/clinem/dgac024.PMID: 35150267
- Gregory AM, Rutter MK, Ware J, Madrid-Valero JJ, Hovorka R, Buysse DJ. Type 1 diabetes as a prototypical condition challenging what we know about sleep. Sleep. 2022 Sep 21:zsac194. doi: 10.1093/sleep/zsac194. PMID:36130325
- Grigoriadis D, Sackey E, Riches K, van Zanten M, Brice G, England R, Mills M, Dobbins SE, Lee LL; Lipoedema Consortium; Genomics England Research Consortium, Jeffery S, Dong L, Savage DB, Mortimer PS, Keeley V, Pittman A, Gordon K, Ostergaard P. Investigation of clinical characteristics and genome associations in the ‘UK Lipoedema’ cohort. PLoS One. 2022 Oct 13;17(10):e0274867. doi: 10.1371/journal.pone.0274867. PMID:36227936 PMCID:PMC9560129
- Guccio N, Gribble FM, Reimann F. Glucose-Dependent Insulinotropic Polypeptide-A Postprandial Hormone with Unharnessed Metabolic Potential. Annu Rev Nutr. 2022 May 24. doi: 10.1146/annurev-nutr-062320-113625. PMID:35609956
- Hall KD, Farooqi IS, Friedman JM, Klein S, Loos RJF, Mangelsdorf DJ, O’Rahilly S, Ravussin E, Redman LM, Ryan DH, Speakman JR, Tobias DK. The energy balance model of obesity: beyond calories in, calories out. Am J Clin Nutr. 2022 Feb 4:nqac031. doi: 10.1093/ajcn/nqac031. PMID:35134825
- Hall KD, Farooqi IS, Friedman JM, Klein S, Loos RJF, Mangelsdorf DJ, O’Rahilly S, Ravussin E, Redman LM, Ryan DH, Speakman JR, Tobias DK. Reply to Taubes, Friedman, and Torres-Carot et al. Am J Clin Nutr. 2022 Jun 8:nqac163. doi: 10.1093/ajcn/nqac163. PMID:35675318
- Hart RI, Kimbell B, Rankin D, Allen JM, Boughton CK, Campbell F, de Beaufort C, Fröhlich-Reiterer E, Ware J, Hofer SE, Kapellen TM, Rami-Merhar B, Thankamony A, Hovorka R, Lawton J; KidsAP Consortium. Parents’ experiences of using remote monitoring technology to manage type 1 diabetes in very young children during a clinical trial: Qualitative study. Diabet Med. 2022 Jul;39(7):e14828. doi: 10.1111/dme.14828. PMID:35274356
- Herzig D, Suhner S, Roos J, Schürch D, Cecchini L, Nakas CT, Weiss S, Kadner A, Kocher GJ, Guensch DP, Wilinska ME, Raabe A, Siebenrock KA, Beldi G, Gloor B, Hovorka R, Vogt AP, Bally L. Perioperative Fully Closed-Loop Insulin Delivery in Patients Undergoing Elective Surgery: An Open-Label, Randomized Controlled Trial. Diabetes Care. 2022 Sep 1;45(9):2076-2083. doi: 10.2337/dc22-0438. PMID:35880252
- Hood KK, Garcia-Willingham N, Hanes S, Tanenbaum ML, Ware J, Boughton CK, Allen JM, Wilinska ME, Tauschmann M, Denvir L, Thankamony A, Campbell F, Wadwa RP, Buckingham BA, Davis N, DiMeglio LA, Mauras N, Besser RE, Ghatak A, Weinzimer SA, Fox DS, Kanapka L, Kollman C, Sibayan J, Beck RW, Hovorka R; DAN05 Consortium. Lived experience of CamAPS FX closed loop system in youth with type 1 diabetes and their parents. Diabetes Obes Metab. 2022 Jul 15. doi: 10.1111/dom.14815. PMID:35837984
- Hu G, Ling C, Chi L, Thind MK, Furse S, Koulman A, Swann JR, Lee D, Calon MM, Bourdon C, Versloot CJ, Bakker BM, Gonzales GB, Kim PK, Bandsma RHJ. The role of the tryptophan-NAD + pathway in a mouse model of severe malnutrition induced liver dysfunction. Nat Commun. 2022 Dec 8;13(1):7576. doi: 10.1038/s41467-022-35317-y. PMID:36481684 PMCID:PMC9732354
- Hudert CA, Adams LA, Alisi A, Anstee QM, Crudele A, Draijer LG; EU-PNAFLD investigators, Furse S, Hengstler JG, Jenkins B, Karnebeek K, Kelly DA, Koot BG, Koulman A, Meierhofer D, Melton PE, Mori TA, Snowden SG, van Mourik I, Vreugdenhil A, Wiegand S, Mann JP. Variants in mitochondrial amidoxime reducing component 1 and hydroxysteroid 17-beta dehydrogenase 13 reduce severity of nonalcoholic fatty liver disease in children and suppress fibrotic pathways through distinct mechanisms. Hepatol Commun. 2022 Apr 11. doi: 10.1002/hep4.1955. PMID:35411667
- Hufnagel A, Dearden L, Fernandez-Twinn DS, Ozanne SE. Programming of cardio metabolic health: the role of maternal and fetal hyperinsulinaemia. J Endocrinol. 2022 Mar 1;JOE-21-0332. doi: 10.1530/JOE-21-0332. PMID: 35258482
- Inzani I, Ozanne SE. Programming by maternal obesity: a pathway to poor cardiometabolic health in the offspring. Proc Nutr Soc. 2022 Jul 29:1-16. doi: 10.1017/S0029665122001914. PMID:35974421
- Karusheva Y, Ratcliff,M, Melvin A, Mörseburg A, Sattar N, Barker P, Burling K, Backmark A, Roth R, Jermutus L, Guiu-Jurado E, Blüher M, Welsh P, Hyvönen M, O’Rahilly S. The common H202D variant in GDF-15 does not affect its bioactivity but can significantly interfere with measurement of its circulating levels. MedRxiv https://doi.org/10.1101/2022.01.03.22268655
- Khan D, Ojo OO, Woodward OR, Lewis JE, Sridhar A, Gribble FM, Reimann F, Flatt PR, Moffett RC. Evidence for Involvement of GIP and GLP-1 Receptors and the Gut-Gonadal Axis in Regulating Female Reproductive Function in Mice. Biomolecules. 2022 Nov 23;12(12):1736.
doi: 10.3390/biom12121736. PMID:36551163 PMCID:PMC9775379 - Kimbell B, Rankin D, Hart RI, Allen JM, Boughton CK, Campbell F, Fröhlich-Reiterer E, Hofer SE, Kapellen TM, Rami-Merhar B, Schierloh U, Thankamony A, Ware J, Hovorka R, Lawton J; KidsAP consortium. Parents’ experiences of using a hybrid closed-loop system (CamAPS FX) to care for a very young child with type 1 diabetes: Qualitative study. Diabetes Res Clin Pract. 2022 May;187:109877. doi: 10.1016/j.diabres.2022.109877. PMID:35469973
- Kimbell B, Rankin D, Hart RI, Allen JM, Boughton CK, Campbell F, Fröhlich-Reiterer E, Hofer SE, Kapellen TM, Rami-Merhar B, Schierloh U, Thankamony A, Ware J, Hovorka R, Lawton J; KidsAP Consortium. Parents’ views about healthcare professionals having real-time remote access to their young child’s diabetes data: Qualitative study. Pediatr Diabetes. 2022 May 13. doi: 10.1111/pedi.13363. PMID:35561092
- Kincaid JWR, Coll AP. Metformin and GDF15: where are we now? Nat Rev Endocrinol. 2023 Jan;19(1):6-7. doi: 10.1038/s41574-022-00764-6. PMID:36271034
- Klonoff DC, Wang J, Rodbard D, Kohn MA, Li C, Liepmann D, Kerr D, Ahn D, Peters AL, Umpierrez GE, Seley JJ, Xu NY, Nguyen KT, Simonson G, Agus MSD, Al-Sofiani ME, Armaiz-Pena G, Bailey TS, Basu A, Battelino T, Bekele SY, Benhamou PY, Bequette BW, Blevins T, Breton MD, Castle JR, Chase JG, Chen KY, Choudhary P, Clements MA, Close KL, Cook CB, Danne T, Doyle FJ 3rd, Drincic A, Dungan KM, Edelman SV, Ejskjaer N, Espinoza JC, Fleming GA, Forlenza GP, Freckmann G, Galindo RJ, Gomez AM, Gutow HA, Heinemann L, Hirsch IB, Hoang TD, Hovorka R, Jendle JH, Ji L, Joshi SR, Joubert M, Koliwad SK, Lal RA, Lansang MC, Lee WA, Leelarathna L, Leiter LA, Lind M, Litchman ML, Mader JK, Mahoney KM, Mankovsky B, Masharani U, Mathioudakis NN, Mayorov A, Messler J, Miller JD, Mohan V, Nichols JH, Nørgaard K, O’Neal DN, Pasquel FJ, Philis-Tsimikas A, Pieber T, Phillip M, Polonsky WH, Pop-Busui R, Rayman G, Rhee EJ, Russell SJ, Shah VN, Sherr JL, Sode K, Spanakis EK, Wake DJ, Waki K, Wallia A, Weinberg ME, Wolpert H, Wright EE, Zilbermint M, Kovatchev B. A Glycemia Risk Index (GRI) of Hypoglycemia and Hyperglycemia for Continuous Glucose Monitoring Validated by Clinician Ratings. J Diabetes Sci Technol. 2022 Mar 29:19322968221085273. doi: 10.1177/19322968221085273. PMID:35348391
- Koo A, Pustovit RV, Woodward ORM, Lewis JE, Gribble FM, Hossain MA, Reimann F, Furness JB. Expression of the relaxin family peptide 4 receptor by enterochromaffin cells of the mouse large intestine. Cell Tissue Res. 2022 Jul;389(1):1-9. doi: 10.1007/s00441-022-03635-8. PMID:35596811 PMCID:PMC9200676
- Koulman A, Rennie KL, Parkington D, Tyrrell CS, Catt M, Gkrania-Klotsas E, Wareham NJ. The development, validation and application of remote blood sample collection in telehealth programmes. J Telemed Telecare. 2022 May 10:1357633X221093434. doi: 10.1177/1357633X221093434. PMID:35538704
- LaPierre MP, Lawler K, Godbersen S, Farooqi IS, Stoffel M. MicroRNA-7 regulates melanocortin circuits involved in mammalian energy homeostasis. Nat Commun. 2022 Sep 29;13(1):5733. doi: 10.1038/s41467-022-33367-w. PMID:36175420 PMCID:PMC9522793
- Lee TTM, Collett C, Man MS, Hammond M, Shepstone L, Hartnell S, Gurnell E, Byrne C, Scott EM, Lindsay RS, Morris D, Brackenridge A, Dover AR, Reynolds RM, Hunt KF, McCance DR, Barnard-Kelly K, Rankin D, Lawton J, Bocchino LE, Sibayan J, Kollman C, Wilinska ME, Hovorka R, Murphy HR; AiDAPT Collaborative Group. AiDAPT: automated insulin delivery amongst pregnant women with type 1 diabetes: a multicentre randomized controlled trial – study protocol. BMC Pregnancy Childbirth. 2022 Apr 5;22(1):282. doi: 10.1186/s12884-022-04543-z. PMID:35382796 PMCID:PMC8982306
- Leelarathna L, Evans ML, Neupane S, Rayman G, Lumley S, Cranston I, Narendran P, Barnard-Kelly K, Sutton CJ, Elliott RA, Taxiarchi VP, Gkountouras G, Burns M, Mubita W, Kanumilli N, Camm M, Thabit H, Wilmot EG; FLASH-UK Trial Study Group. Intermittently Scanned Continuous Glucose Monitoring for Type 1 Diabetes. N Engl J Med. 2022 Oct 5. doi: 10.1056/NEJMoa2205650. PMID:36198143
- Lewis JE, Woodward OR, Nuzzaci D, Smith CA, Adriaenssens AE, Billing L, Brighton C, Phillips BU, Tadross JA, Kinston SJ, Ciabatti E, Göttgens B, Tripodi M, Hornigold D, Baker D, Gribble FM, Reimann F. Relaxin/insulin-like family peptide receptor 4 (Rxfp4) expressing hypothalamic neurons modulate food intake and preference in mice. Mol Metab. 2022 Sep 30:101604. doi: 10.1016/j.molmet.2022.101604. PMID:36184065
- Li C, Feng Y, Fu Z, Deng J, Gu Y, Wang H, Wu X, Huang Z, Zhu Y, Liu Z, Huang M, Wang T, Hu S, Yao B, Zeng Y, Zhou CJ, Brown SDM, Liu Y, Vidal-Puig A, Dong Y, Xu Y. Human-specific gene CT47 blocks PRMT5 degradation to lead to meiosis arrest. Cell Death Discov. 2022 Aug 2;8(1):345. doi: 10.1038/s41420-022-01139-6. PMID:35918318 PMCID:PMC9345867
- Mba CM, Koulman A, Forouhi NG, Sharp SJ, Imamura F, Jones K, Meadows SR, Assah F, Mbanya JC, Wareham NJ. Association between circulating 25-hydroxyvitamin D and cardiometabolic risk factors in adults in rural and urban settings. Nutr Diabetes. 2022 Jul 29;12(1):34. doi: 10.1038/s41387-022-00215-1. PMID:35906229 PMCID:PMC9338254
- Mann JP, Jenkins B, Furse S, Snowden SG, Alisi A, Draijer LG, Karnebeek K, Kelly DA, Koot BG, Mosca A, Salvestrini C, van Mourik I, Vreugdenhil A, Zilbauer M, Koulman A; EU-PNAFLD investigators^. Comparison of the Lipidomic Signature of Fatty Liver in Children and Adults: A Cross-Sectional Study. J Pediatr Gastroenterol Nutr. 2022 Feb 21. doi: 10.1097/MPG.0000000000003418. PMID:35185113
- Meek CL, Oram RA, McDonald TJ, Feig DS, Hattersley AT, Murphy HR. Response to Comment on Meek et al. Reappearance of C-Peptide During the Third Trimester in Type 1 Diabetes Pregnancy: Pancreatic Regeneration or Fetal Hyperinsulinism? Diabetes Care 2021;44:1826-1834. Diabetes Care. 2022 Feb 1;45(2):e43-e44. doi: 10.2337/dci21-0054. PMID:35050370
- Mendes de Oliveira E, Keogh JM, Farooqi IS. Obesity-Associated GNAS Mutations and the Melanocortin Pathway. Reply. N Engl J Med. 2022 Jul 21;387(3):285-286. doi: 10.1056/NEJMc2119110. PMID:35857674
- Menzies-Gow A, Gurnell M, Heaney LG, Corren J, Bel EH, Maspero J, Harrison T, Jackson DJ, Price D, Lugogo N, Kreindler J, Burden A, de Giorgio-Miller A, Faison S, Padilla K, Martin UJ, Garcia Gil E; PONENTE Study Group. Adrenal function recovery after durable OCS-sparing with benralizumab in the PONENTE study. Eur Respir J. 2022 Jul 26:2103226. doi: 10.1183/13993003.03226-2021. PMID:35896216
- Menzies-Gow A, Kreindler J, Katial R, Gurnell M. Adrenal insufficiency in patients taking benralizumab as corticosteroid sparing therapy – Authors’ reply. Lancet Respir Med. 2022 Jan;10(1):e8.doi: 10.1016/S2213-2600(21)00489-6. PMID: 34762847
- Merkle FT, Ghosh S, Genovese G, Handsaker RE, Kashin S, Meyer D, Karczewski KJ, O’Dushlaine C, Pato C, Pato M, MacArthur DG, McCarroll SA, Eggan K. Whole-genome analysis of human embryonic stem cells enables rational line selection based on genetic variation. Cell Stem Cell. 2022 Mar 3;29(3):472-486.e7. doi: 10.1016/j.stem.2022.01.011. PMID:35176222 PMCID:PMC8900618
- Miedzybrodzka EL, Gribble FM, Reimann F. Targeting the Enteroendocrine System for Treatment of Obesity. Handb Exp Pharmacol. 2022 Apr 14. doi: 10.1007/164_2022_583. PMID:35419620
- Miedzybrodzka EL, Reimann F, Gribble FM. The Enteroendocrine System in Obesity. Handb Exp Pharmacol. 2022 Apr 14. doi: 10.1007/164_2022_582. PMID:35419621
- Mitchell E, Chapman MS, Williams N, Dawson KJ, Mende N, Calderbank EF, Jung H, Mitchell T, Coorens T, Spencer D, Machado H, Lee-Six H, Davies M, Hayler D, Fabre M, Mahbubani K, Abascal F, Cagan A, Vassiliou G, Baxter J, Martincorena I, Stratton MR, Kent D, Chatterjee K, Saeb-Parsy K, Green AR, Nangalia J, Laurenti E, Campbell PJ. Clonal dynamics of haematopoiesis across the human lifespan. Nature (2022) DOI: 10.1038/s41586-022-04786-y. PMID:35650442 PMCID:PMC9177428
- Mocciaro G, D’Amore S, Jenkins B, Kay R, Murgia A, Herrera-Marcos LV, Neun S, Sowton AP, Hall Z, Palma-Duran SA, Palasciano G, Reimann F, Murray A, Suppressa P, Sabbà C, Moschetta A, Koulman A, Griffin JL, Vacca M. Lipidomic Approaches to Study HDL Metabolism in Patients with Central Obesity Diagnosed with Metabolic Syndrome. Int J Mol Sci. 2022 Jun 17;23(12):6786. doi: 10.3390/ijms23126786. PMID:35743227 PMCID:PMC9223701
- Moran C, Schoenmakers N, Visser WE, Schoenmakers E, Agostini M, Chatterjee K. Genetic disorders of thyroid development, hormone biosynthesis and signalling. Clin Endocrinol (Oxf). 2022 Oct;97(4):502-514. doi: 10.1111/cen.14817. PMID:35999191 PMCID:PMC9544560
- Morgan HL, Furse S, Dias IHK, Shabir K, Castellanos M, Khan I, May ST, Holmes N, Carlile M, Sang F, Wright V, Koulman A, Watkins AJ. Paternal low protein diet perturbs inter-generational metabolic homeostasis in a tissue-specific manner in mice. Commun Biol. 2022 Sep 8;5(1):929. doi: 10.1038/s42003-022-03914-8. PMID:36075960 PMCID:PMC9458637
- Mörseburg A, Pagani L, Malyarchuk B, Derenko M, Kivisild T. Response to Wyckelsma et al.: Loss of α-actinin-3 during human evolution provides superior cold resilience and muscle heat generation. The American Journal of Human Genetics, 109(5), 967–972. PMID:35523147 PMCID:PMC9118108
- Mosbah H, Akinci B, Araújo-Vilar D, Carrion Tudela J, Ceccarini G, Collas P, Farooqi IS, Fernández-Pombo A, Jéru I, Karpe F, Krause K, Maffei M, Miehle K, Oral E, Perez de Tudela N, Prieur X, Rochford J, Sanders R, Santini F, Savage DB, von Schnurbein J, Semple R, Stears A, Sorkina E, Vantyghem MC, Vatier C, Vidal-Puig A, Vigouroux C, Wabitsch M. Proceedings of the annual meeting of the European Consortium of Lipodystrophies (ECLip) Cambridge, UK, 7-8 April 2022. Ann Endocrinol (Paris). 2022 Oct 4:S0003-4266(22)00841-1. doi: 10.1016/j.ando.2022.07.674. PMID:
- Muzurović E, Borozan S, Vujošević S, Gurnell M. Thyroid status and vascular risk: an update. Curr Vasc Pharmacol. 2022 Oct 4. doi: 10.2174/1570161120666221004144414. PMID:36200192
- Olga L, Bobeldijk-Pastorova I, Bas RC, Seidel F, Snowden SG, Furse S, Ong KK, Kleemann R, Koulman A. Lipid profiling analyses from mouse models and human infants. STAR Protoc. 2022 Sep 15;3(4):101679. doi: 10.1016/j.xpro.2022.101679. PMID:36115026 PMCID:PMC9486117
- Pantazis CB, Yang A, Lara E, McDonough JA, Blauwendraat C, Peng L, Oguro H, Kanaujiya J, Zou J, Sebesta D, Pratt G, Cross E, Blockwick J, Buxton P, Kinner-Bibeau L, Medura C, Tompkins C, Hughes S, Santiana M, Faghri F, Nalls MA, Vitale D, Ballard S, Qi YA, Ramos DM, Anderson KM, Stadler J, Narayan P, Papademetriou J, Reilly L, Nelson MP, Aggarwal S, Rosen LU, Kirwan P, Pisupati V, Coon SL, Scholz SW, Priebe T, Öttl M, Dong J, Meijer M, Janssen LJM, Lourenco VS, van der Kant R, Crusius D, Paquet D, Raulin AC, Bu G, Held A, Wainger BJ, Gabriele RMC, Casey JM, Wray S, Abu-Bonsrah D, Parish CL, Beccari MS, Cleveland DW, Li E, Rose IVL, Kampmann M, Calatayud Aristoy C, Verstreken P, Heinrich L, Chen MY, Schüle B, Dou D, Holzbaur ELF, Zanellati MC, Basundra R, Deshmukh M, Cohen S, Khanna R, Raman M, Nevin ZS, Matia M, Van Lent J, Timmerman V, Conklin BR, Johnson Chase K, Zhang K, Funes S, Bosco DA, Erlebach L, Welzer M, Kronenberg-Versteeg D, Lyu G, Arenas E, Coccia E, Sarrafha L, Ahfeldt T, Marioni JC, Skarnes WC, Cookson MR, Ward ME, Merkle FT. A reference human induced pluripotent stem cell line for large-scale collaborative studies. Cell Stem Cell. 2022 Dec 1;29(12):1685-1702.e22. PMID:36459969
- Pantaleao LC, Inzani I, Furse S, Loche E, Hufnagel A, Ashmore T, Blackmore HL, Jenkins B, Carpenter AAM, Wilczynska A, Bushell M, Koulman A, Fernandez-Twinn DS, Ozanne SE. Maternal diet-induced obesity during pregnancy alters lipid supply to mouse E18.5 fetuses and changes the cardiac tissue lipidome in a sex-dependent manner. Elife. 2022 Jan 13;11:e69078. doi: 10.7554/eLife.69078. PMID:35025731
- Patel S, Haider A, Alvarez-Guaita A, Bidault G, El-Sayed Moustafa JS, Guiu-Jurado E, Tadross JA, Warner J, Harrison J, Virtue S, Scurria F, Zvetkova I, Blüher M, Small KS, O’Rahilly S, Savage DB. Combined genetic deletion of GDF15 and FGF21 has modest effects on body weight, hepatic steatosis and insulin resistance in high fat fed mice. Mol Metab. 2022 Nov;65:101589. doi: 10.1016/j.molmet.2022.101589. PMID:36064109 PMCID:PMC9486046
- Pellegrinelli V, Rodriguez-Cuenca S, Rouault C, Figueroa-Juarez E, Schilbert H, Virtue S, Moreno-Navarrete JM, Bidault G, Vázquez-Borrego MC, Dias AR, Pucker B, Dale M, Campbell M, Carobbio S, Lin YH, Vacca M, Aron-Wisnewsky J, Mora S, Masiero MM, Emmanouilidou A, Mukhopadhyay S, Dougan G, den Hoed M, Loos RJF, Fernández-Real JM, Chiarugi D, Clément K, Vidal-Puig A. Dysregulation of macrophage PEPD in obesity determines adipose tissue fibro-inflammation and insulin resistance. Nat Metab. 2022 Apr;4(4):476-494. doi: 10.1038/s42255-022-00561-5. PMID:35478031
- Perdikari A, Cacciottolo T, Henning E, Mendes de Oliveira E, Keogh JM, Farooqi IS. Visualization of sympathetic neural innervation in human white adipose tissue. Open Biol. 2022 Mar;12(3):210345. doi: 10.1098/rsob.210345. PMID:35291877 PMCID:PMC8924755
- Perry ACF, Asami M, Lam BYH, Yeo GSH. The initiation of mammalian embryonic transcription: to begin at the beginning. Trends Cell Biol. 2022 Sep 28:S0962-8924(22)00211-2. doi: 10.1016/j.tcb.2022.08.008. PMID:36182534
- Peters C, Schoenmakers N. MECHANISMS IN ENDOCRINOLOGY: The pathophysiology of transient congenital hypothyroidism. Eur J Endocrinol. 2022 Jun 20;187(2):R1-R16. doi: 10.1530/EJE-21-1278. PMID:35588090
- Phillip M, Nimri R, Bergenstal RM, Barnard-Kelly K, Danne T, Hovorka R, Kovatchev BP, Messer LH, Parkin CG, Ambler-Osborn L, Amiel SA, Bally L, Beck RW, Biester S, Biester T, Blanchette JE, Bosi E, Boughton CK, Breton MD, Brown SA, Buckingham BA, Cai A, Carlson AL, Castle JR, Choudhary P, Close KL, Cobelli C, Criego AB, Davis E, de Beaufort C, de Bock MI, DeSalvo DJ, DeVries JH, Dovc K, Doyle FJ, Ekhlaspour L, Shvalb NF, Forlenza GP, Gallen G, Garg SK, Gershenoff DC, Gonder-Frederick LA, Haidar A, Hartnell S, Heinemann L, Heller S, Hirsch IB, Hood KK, Isaacs D, Klonoff DC, Kordonouri O, Kowalski A, Laffel L, Lawton J, Lal RA, Leelarathna L, Maahs DM, Murphy HR, Nørgaard K, O’Neal D, Oser S, Oser T, Renard E, Riddell MC, Rodbard D, Russell SJ, Schatz DA, Shah VN, Sherr JL, Simonson GD, Wadwa RP, Ward C, Weinzimer SA, Wilmot EG, Battelino T. Consensus Recommendations for the Use of Automated Insulin Delivery (AID) Technologies in Clinical Practice. Endocr Rev. 2022 Sep 6:bnac022. doi: 10.1210/endrev/bnac022. PMID:36066457
- Putt O, Westacott R, Sam AH, Gurnell M, Brown CA. Using very short answer errors to guide teaching. Clin Teach. 2022 Apr;19(2):100-105. doi: 10.1111/tct.13458. PMID: 35078276
- Romero-Picó A, Novelle MG, Al-Massadi O, Beiroa D, Tojo M, Heras V, Ruiz-Pino F, Senra A, López M, Blouet C, Tena-Sempere M, Nogueiras R, Diéguez C. Kappa-Opioid Receptor Blockade Ameliorates Obesity Caused by Estrogen Withdrawal via Promotion of Energy Expenditure through mTOR Pathway. Int J Mol Sci. 2022 Mar 14;23(6):3118. doi: 10.3390/ijms23063118. PMID:35328539 PMCID:PMC8953356
- Romartinez-Alonso B*, Agostini M*, Jones H, McLellan J, Sood D, Tomkinson N, Marelli F, Gentile I, Visser WE, Schoenmakers E, Fairall F, Privalsky M, Moran C, Persani L, Chatterjee K†, John Schwabe J†. Structure-guided approach to relieving transcriptional repression in Resistance to Thyroid Hormone alpha. Molecular and Cellular Biology (2022) (*coequal first authors;†joint senior authors). doi.org/10.1128/MCB.00363-21. PMID:34871063 PMCID:PMC8852717
- Ruiz Nishiki M, Cabecinha M, Knowles R, Peters C, Aitkenhead H, Ifederu A, Schoenmakers N, Sebire NJ, Walker E, Hardelid P. Establishing risk factors and outcomes for congenital hypothyroidism with gland in situ using population-based data linkage methods: study protocol. BMJ Paediatr Open. 2022 Mar;6(1):e001341. doi: 10.1136/bmjpo-2021-001341. PMID:36053651 PMCID:PMC8969044
- Sabaté-Pérez A, Romero M, Sànchez-Fernàndez-de-Landa P, Carobbio S, Mouratidis M, Sala D, Engel P, Martínez-Cristóbal P, Villena JA, Virtue S, Vidal-Puig A, Palacín M, Testar X, Zorzano A. Autophagy-mediated NCOR1 degradation is required for brown fat maturation and thermogenesis. Autophagy. 2022 Aug 25:1-22. doi: 10.1080/15548627.2022.2111081. PMID:35947488
- Sandovici I, Fernandez-Twinn DS, Hufnagel A, Constância M, Ozanne SE. Sex differences in the intergenerational inheritance of metabolic traits. Nat Metab. 2022 May;4(5):507-523. doi: 10.1038/s42255-022-00570-4. PMID:35637347
- Sandovici I, Reiterer M, Constância M, Branco CM. Protocol to isolate and culture primary mouse feto-placental endothelial cells. STAR Protoc. 2022 Sep 24;3(4):101721. doi: 10.1016/j.xpro.2022.101721. PMID:36153734 PMCID:PMC9513276
- Sathyanarayanan A, Crabtree T, Choudhary P, Elliott J, Evans ML, Lumb A, Wilmot EG. Delivering evidence-based interventions for type 1 diabetes in the virtual world – A review of UK practice during the SARS-CoV-2 pandemic. Diabetes Res Clin Pract. 2022 Mar;185:109777. doi: 10.1016/j.diabres.2022.109777. PMID:35157943 PMCID:PMC8831709
- Schoonejans JM, Blackmore HL, Ashmore TJ, Pantaleão LC, Pellegrini Pisani L, Dearden L, Tadross JA, Aiken CE, Fernandez-Twinn DS, Ozanne SE. Sex-specific effects of maternal metformin intervention during glucose-intolerant obese pregnancy on body composition and metabolic health in aged mouse offspring. Diabetologia. 2022 Sep 16. doi: 10.1007/s00125-022-05789-0. PMID:36112170
- Scoffings K, Morris D, Pullen A, Temple S, Trigell A, Gurnell M. Recognising and diagnosing Cushing’s syndrome in primary care: challenging but not impossible. Br J Gen Pract. 2022 Jul 28;72(721):399-401. doi: 10.3399/bjgp22X720449. PMID:35902256 PMCID:PMC9343052
- Sebek J, Cappiello G, Rahmani G, Zeinali N, Keating M, Fayemiwo M, Harkin J, McDaid L, Gardiner B, Sheppard D, Senanayake R, Gurnell M, O’Halloran M, Dennedy MC, Prakash P. Image-based computer modeling assessment of microwave ablation for treatment of adrenal tumors. Int J Hyperthermia. 2022;39(1):1264-1275. doi: 10.1080/02656736.2022.2125590. PMID:36137605
- Sen P, Govaere O, Sinioja T, McGlinchey A, Geng D, Ratziu V, Bugianesi E, Schattenberg JM, Vidal-Puig A, Allison M, Cockell S, Daly AK, Hyötyläinen T, Anstee QM, Orešič M. Quantitative modeling of human liver reveals dysregulation of glycosphingolipid pathways in nonalcoholic fatty liver disease. iScience. 2022 Aug 15;25(9):104949. doi: 10.1016/j.isci.2022.104949. PMID:36065182 PMCID:PMC9440293
- Seyres D, Cabassi A, Lambourne JJ, Burden F, Farrow S, McKinney H, Batista J, Kempster C, Pietzner M, Slingsby O, Cao TH, Quinn PA, Stefanucci L, Sims MC, Rehnstrom K, Adams CL, Frary A, Ergüener B, Kreuzhuber R, Mocciaro G, D’Amore S, Koulman A, Grassi L, Griffin JL, Ng LL, Park A, Savage DB, Langenberg C, Bock C, Downes K, Wareham NJ, Allison M, Vacca M, Kirk PDW, Frontini M.Transcriptional, epigenetic and metabolic signatures in cardiometabolic syndrome defined by extreme phenotypes. Clin Epigenetics. 2022 Mar 12;14(1):39. doi: 10.1186/s13148-022-01257-z. PMID: 35279219
- Silins I, Sundin A, Lubberink M, O’Sullivan L, Gurnell M, Aigbirhio F, Brown M, Wall A, Åkerström T, Roslin S, Hellman P, Antoni G. First-in-human evaluation of [18F]CETO: a novel tracer for adrenocortical tumours. Eur J Nucl Med Mol Imaging. 2022 Sep 8. doi: 10.1007/s00259-022-05957-9. PMID:36074157
- Smith C, Patterson-Cross R, Woodward O, Lewis J, Chiarugi D, Merkle F, Gribble F, Reimann F, Adriaenssens A. (2022). A comparative transcriptomic analysis of glucagon-like peptide-1 receptor- and glucose-dependent insulinotropic polypeptide receptor-expressing cells in the hypothalamus. Appetite, 174, 106022. PMID:35430298
- Steuernagel L, Lam BYH, Klemm P, Dowsett GKC, Bauder CA, Tadross JA, Hitschfeld TS, Del Rio Martin A, Chen W, de Solis AJ, Fenselau H, Davidsen P, Cimino I, Kohnke SN, Rimmington D, Coll AP, Beyer A, Yeo GSH, Brüning JC. HypoMap-a unified single-cell gene expression atlas of the murine hypothalamus. Nat Metab. 2022 Oct;4(10):1402-1419. doi: 10.1038/s42255-022-00657-y. PMID:36266547 PMCID:PMC9584816
- Tarry-Adkins JL, Robinson IG, Reynolds RM, Aye ILMH, Charnock-Jones DS, Jenkins B, Koulmann A, Ozanne SE, Aiken CE.Impact of Metformin Treatment on Human Placental Energy Production and Oxidative Stress. Front Cell Dev Biol. 2022 Jun 17;10:935403. doi: 10.3389/fcell.2022.935403. PMID:35784487 PMCID:PMC9247405
- van Beijsterveldt IALP, Myers PN, Snowden SG, Ong KK, Brix S, Hokken-Koelega ACS, Koulman A. Distinct infant feeding type-specific plasma metabolites at age 3 months associate with body composition at 2 years. A Clin Nutr. 2022 Jun;41(6):1290-1296. doi: 10.1016/j.clnu.2022.04.015. PMID:35537379
- Venables MC, Roberts C, Nicholson S, Bates B, Jones KS, Ashford R, Hill S, Farooq A, Koulman A, Wareham NJ, Page P. Data Resource Profile: United Kingdom National Diet and Nutrition Survey Rolling Programme (2008-19). Int J Epidemiol. 2022 May 28:dyac106. doi: 10.1093/ije/dyac106. PMID:35640141
- Ventsel M, Pechey E, De-Loyde K, Pilling MA, Morris RW, Maistrello G, Ziauddeen H, Marteau TM, Hollands GJ, Fletcher PC. Effect of health warning labels on motivation towards energy-dense snack foods: Two experimental studies. Appetite. 2022 May 14;175:106084. doi: 10.1016/j.appet.2022.106084. PMID:35580820
- Veprik A, Denwood G, Liu D, Bany Bakar R, Morfin V, McHugh K, Tebeka NN, Vetterli L, Yonova-Doing E, Gribble F, Reimann F, Hoehn KL, Hemsley PA, Ahnfelt-Rønne J, Rorsman P, Zhang Q, de Wet H, Cantley J. Acetyl-CoA-carboxylase 1 (ACC1) plays a critical role in glucagon secretion. Commun Biol. 2022 Mar 18;5(1):238. doi: 10.1038/s42003-022-03170-w. PMID:35304577
- Verhulst CEM, Fabricius TW, Nefs G, Kessels RPC, Pouwer F, Teerenstra S, Tack CJ, Broadley MM, Kristensen PL, McCrimmon RJ, Heller S, Evans ML, Pedersen-Bjergaard U, de Galan BE. Consistent Effects of Hypoglycemia on Cognitive Function in People With or Without Diabetes. Diabetes Care. 2022 Sep 1;45(9):2103-2110. doi: 10.2337/dc21-2502. PMID:35876660 PMCID:PMC9472511
- Verhulst CEM, Fabricius TW, Teerenstra S, Kristensen PL, Tack CJ, McCrimmon RJ, Heller S, Evans ML, Amiel SA, Pedersen-Bjergaard U, de Galan BE; Hypo-RESOLVE consortium. Glycaemic thresholds for counterregulatory hormone and symptom responses to hypoglycaemia in people with and without type 1 diabetes: a systematic review. Diabetologia. 2022 Oct;65(10):1601-1612. doi: 10.1007/s00125-022-05749-8. PMID:35867127 PMCID:PMC9477942
- Ware J, Allen JM, Boughton CK, Wilinska ME, Hartnell S, Thankamony A, de Beaufort C, Schierloh U, Fröhlich-Reiterer E, Mader JK, Kapellen TM, Rami-Merhar B, Tauschmann M, Nagl K, Hofer SE, Campbell FM, Yong J, Hood KK, Lawton J, Roze S, Sibayan J, Bocchino LE, Kollman C, Hovorka R; KidsAP Consortium. Randomized Trial of Closed-Loop Control in Very Young Children with Type 1 Diabetes. N Engl J Med. 2022 Jan 20;386(3):209-219. doi: 10.1056/NEJMoa2111673. PMID:35045227
- Ware J, Boughton CK, Allen JM, Wilinska ME, Tauschmann M, Denvir L, Thankamony A, Campbell FM, Wadwa RP, Buckingham BA, Davis N, DiMeglio LA, Mauras N, Besser REJ, Ghatak A, Weinzimer SA, Hood KK, Fox DS, Kanapka L, Kollman C, Sibayan J, Beck RW, Hovorka R; DAN05 Consortium. Cambridge hybrid closed-loop algorithm in children and adolescents with type 1 diabetes: a multicentre 6-month randomised controlled trial. Lancet Digit Health. 2022 Mar 7:S2589-7500(22)00020-6. doi: 10.1016/S2589-7500(22)00020-6. PMID:35272971
- Ware J, Hovorka R. Closed-Loop Control in Very Young Children with Type 1 Diabetes. Reply. N Engl J Med. 2022 Apr 14;386(15):1482-1483. doi: 10.1056/NEJMc2202163. PMID:35417647
- Ware J, Hovorka R. Closed-loop insulin delivery: update on the state of the field and emerging technologies. Expert Rev Med Devices. 2022 Nov;19(11):859-875. doi: 10.1080/17434440.2022.2142556. PMID:36331211 PMCID:PMC9780196
- Ware J, Wilinska ME, Ruan Y, Allen JM, Boughton CK, Hartnell S, Bally L, de Beaufort C, Besser REJ, Campbell FM, Draxlbauer K, Elleri D, Evans ML, Fröhlich-Reiterer E, Ghatak A, Hofer SE, Kapellen TM, Leelarathna L, Mader JK, Mubita WM, Narendran P, Poettler T, Rami-Merhar B, Tauschmann M, Randell T, Thabit H, Thankamony A, Trevelyan N, Hovorka R. Safety of user-initiated intensification of insulin delivery using Cambridge hybrid closed-loop algorithm. J Diabetes Sci Technol. 2022 Dec 8:19322968221141924. doi: 10.1177/19322968221141924. PMID:36475908
- Wei W, Chen Q, Liu M, Sheng Y, OuYang Q, Feng W, Yang X, Ding L, Su S, Zhang J, Fang L, Vidal-Puig A, Wang HY, Chen S. TRIM24 is an insulin-responsive regulator of P-bodies. Nat Commun. 2022 Jul 8;13(1):3972. doi: 10.1038/s41467-022-31735-0. PMID:35803934 PMCID:PMC9270398
- Welsh P, Kimenai DM, Marioni RE, Hayward C, Campbell A, Porteous D, Mills NL, O’Rahilly S, Sattar N. Reference ranges for GDF-15, and risk factors associated with GDF-15, in a large general population cohort. Clin Chem Lab Med. 2022 Aug 18;60(11):1820-1829. doi: 10.1515/cclm-2022-0135. PMID:35976089 PMCID:PMC9524804
- Westwater ML, Murley AG, Diederen KMJ, Carpenter TA, Ziauddeen H, Fletcher PC. Characterizing cerebral metabolite profiles in anorexia and bulimia nervosa and their associations with habitual behavior. Transl Psychiatry. 2022 Mar 15;12(1):103. doi: 10.1038/s41398-022-01872-7. PMID:35292626
- Wiegand M, Halsall DJ, Cowan SL, Taylor K, Goudie RJB, Preller J, Gurnell M. Unquantifiably low aldosterone concentrations are prevalent in hospitalised COVID-19 patients but may not be revealed by chemiluminescent immunoassay. Endocr Connect. 2022 Oct 14;11(11):e220190. doi: 10.1530/EC-22-0190. PMID:36006845
- Working Group for Renaming Diabetes Insipidus, Arima H, Cheetham T, Christ-Crain M, Cooper D, Gurnell M, Drummond JB, Levy M, McCormack AI, Verbalis J, Newell-Price J, Wass JAH. Changing the name of diabetes insipidus: a position statement of The Working Group for Renaming Diabetes Insipidus. Endocr J. 2022 Oct 14. doi: 10.1507/endocrj.EJ20220831. PMID:36244744
- Working Group for Renaming Diabetes Insipidus, Arima H, Cheetham T, Christ-Crain M, Cooper D, Gurnell M, Drummond JB, Levy M, McCormack AI, Verbalis J, Newell-Price J, Wass JAH. Changing the name of diabetes insipidus: a position statement of The Working Group for Renaming Diabetes Insipidus. Eur J Endocrinol. 2022 Oct 14;187(5):P1-P3. doi: 10.1530/EJE-22-0751. PMID:36239119
- Working Group for Renaming Diabetes Insipidus, Arima H, Cheetham T, Christ-Crain M, Cooper D, Gurnell M, Drummond JB, Levy M, McCormack AI, Verbalis J, Newell-Price J, Wass JAH. Changing the name of diabetes insipidus: a position statement of The Working Group for Renaming Diabetes Insipidus. Endocr Connect. 2022 Oct 14;11(11):e220378. doi: 10.1530/EC-22-0378. PMID:36228658
- Wu X, Senanayake R, Goodchild E, Bashari WA, Salsbury J, Cabrera CP, Argentesi G, O’Toole SM, Matson M, Koo B, Parvanta L, Hilliard N, Kosmoliaptsis V, Marker A, Berney DM, Tan W, Foo R, Mein CA, Wozniak E, Savage E, Sahdev A, Bird N, Laycock K, Boros I, Hader S, Warnes V, Gillett D, Dawnay A, Adeyeye E, Prete A, Taylor AE, Arlt W, Bhuva AN, Aigbirhio F, Manisty C, McIntosh A, McConnachie A, Cruickshank JK, Cheow H, Gurnell M, Drake WM, Brown MJ. [11C]metomidate PET-CT versus adrenal vein sampling for diagnosing surgically curable primary aldosteronism: a prospective, within-patient trial. Nat Med. 2023 Jan;29(1):190-202. doi: 10.1038/s41591-022-02114-5. PMID:36646800 PMCID:PMC9873572
- Yeo GSH. Is calorie labelling on menus the solution to obesity? Nat Rev Endocrinol. 2022 Aug;18(8):453-454. doi: 10.1038/s41574-022-00705-3. PMID:35680986 PMCID: PMC9179223
- Zhai Q, Zeng Y, Gu Y, Li Z, Zhang T, Yuan B, Wang T, Yan J, Qin H, Yang L, Chen X, Vidal-Puig A, Xu Y. Time-restricted feeding entrains long-term behavioral changes through the IGF2-KCC2 pathway. iScience. 2022 Apr 18;25(5):104267. doi: 10.1016/j.isci.2022.104267. PMID:35521538 PMCID:PMC9062755
- Zhang C, Vincelette LK, Reimann F, Liberles SD. A brainstem circuit for nausea suppression. Cell Rep. 2022 Jun 14;39(11):110953. doi: 10.1016/j.celrep.2022.110953. PMID:35705049
- Zhang JY, Hamey F, Trzupek D, Mickunas M, Lee M, Godfrey L, Yang JHM, Pekalski ML, Kennet J, Waldron-Lynch F, Evans ML, Tree TIM, Wicker LS, Todd JA, Ferreira RC. Low-dose IL-2 reduces IL-21+ T cell frequency and induces anti-inflammatory gene expression in type 1 diabetes. Nat Commun. 2022 Nov 28;13(1):7324. doi: 10.1038/s41467-022-34162-3. PMID:36443294 PMCID:PMC9705541
2021
- 100,00 Genomes Project Pilot Investigators, Smedley D, Smith KR, Martin A, Thomas EA, McDonagh EM, Cipriani V, Ellingford JM, Arno G, Tucci A, Vandrovcova J, Chan G, Willliams HJ, Ratnaike T, Wei W, Stirrups K, Ibanez K, Moutsiansas L, Wielscher M, Need A, Barnes MR, Vestito L, Buchanan J, Wordsworth S, Ashford S, Rehmstrom K, Li E, Fuller G, Twiss P, Spasic-boskovic O, Halsall S, Floto RA, Poole K, Wagner A, Mehta SG, Gurnell M, Burrows N, James R, Penkett C, Dewhurst E, Graf S, Mapeta R, Kasanicki M, Haworth A, Savage H, Babcock M, Reese MG Bale M, Baple E, Boustred C, Brittain H, de Burca A, Bleda M, Devereau A, Halai D, Haraldsdottir E, Hyder Z, Kasperaviciute D, Patch C, Polychronopoulos D, Matchan A, Sultana R, Ryten M, Tavares ALT, Tregidgo C, Turnbull C, Welland M, Wood S, Snow C, Williams E, Leigh S, Foulger RE, Daugherty LC, Niblock O, Leong IUS, Wright CF, Davies J, Crichton C, Welch J, Woods K, Abulhoul L, Aurora P, Bockenhauer D, Broomfield A, Cleary MA, Lam T, Dattani M, Footitt E, Ganesan V, Grunewald S, Compeyrot-Lacassagne S, Muntoni F, Pilkington C, Quinlivan R, Thapar N, Wallis C, Wedderburn LR, Worth A, Bueser T, Compton C, Deshpande C, Fassihi H, Haque E, Izatt L, Josifova D, Mohammed S, Robert L, Rose S, Ruddy D, Sarkany R, Say G, Shaw AC, Wolejko A, Habib B, Burs G, Hunter S, Grocock RJ, Humphray SJ, Robinson PN, Haendel M, Simpson MA, Banka S, Clayton-Smith J, Douzgou S, Hall G, Thomas HB, O’Keefe RT, Michaelides M, Moore AT, Malska S, Pontikos N, Browning AC, Straub V, Gorman GS, Horvath R, Quinton R, Schaefer AM, Yu-Wai-Man P, Turnbull DM, McFarland R, Taylor RW, O’Connor E, Yip J, Newland K, Morris HR, Polke J, Wood NW, Campbell C, Camps C, Gibson K, Koelling N, Lester T, Nemeth AH, Palles C, Patel S, Roy NBA, Sen A, Taylor J, Cacheiro P, Jacobsen JO, Seaby EG, Davison V, Chitty L, Douglas A, Naresh K, McMullan D, Ellard S, Temple IK, Mumford AD, Wilson G, Beales P, Bitner-Glindzica M, Black G, Bradley JR, Brennnan P, Burn J, Chinnery PF, Elliott P, Flinter F, Houlden H, Irving M, Newman W, Rahman S, Sayer JA, Taylor JC, Webster AR, Wilkie AOM, Ouwehand WH, Raymond FL, Chisholm J, Hill S, Bentley D, Scott RH, Fowler T, Rendon A,Caulfield M. 100,000 Genomes Pilot on Rare-Disease Diagnosis in Health Preliminary Report. N Engl J Med. 2021 Nov 11;385(20):1868-1880. doi:10.1056/NEJMoa2035790. PMID:34758253
- Agrawal N, Lawler K, Davidson CM, Keogh JM, Legg R; INTERVAL, Barroso I, Farooqi IS, Brand AH. Predicting novel candidate human obesity genes and their site of action by systematic functional screening in Drosophila. PLoS Biol. 2021 Nov 8;19(11):e3001255. doi: 10.1371/journal.pbio.3001255. PMID:34748544 PMCID:PMC8575313
- Ahmed RM, Tse Ny, Chen Y, Henning E, Hodges JR, Kiernan MC, Irish M, Farooqi IS, Piguet O. Neural correlates of fat preference in frontotemporal dementia: translating insights from the obesity literature. Ann Clin Transl Neurol. 2021 Jun;8(6):1318-1329. doi: 10.1002/acn.51369. PMID:33973740
- Andrade S, Morais T, Sandovici I, Seabra AL, Constância M, Monteiro MP. Adipose Tissue Epigenetic Profile in Obesity-Related Dysglycemia – A Systematic Review. Front Endocrinol (Lausanne). 2021 Jun 29;12:681649. doi: 10.3389/fendo.2021.681649. PMID:34290669 PMCID:PMC8288106
- Angiolini E, Sandovici I, Coan PM, Burton GJ, Sibley CP, Fowden AL, Constância M. Deletion of the Imprinted Phlda2 Gene Increases Placental Passive Permeability in the Mouse. Genes (Basel). 2021 Apr 25;12(5):639. doi: 10.3390/genes12050639. PMID:33922969 PMCID:PMC8146920
- Artero-Castro A, Long K, Bassett A, Avila-Fernandez A, Corton M, Vidal-Puig A, Jendelova P, Rodriguez-Jimenez FJ, Clemente E, Ayuso C, Slaven E, Gene Correction Recovers Phagocytosis in Retinal Pigment Epithelium Derived from Retinitis Pigmentosa-Human-Induced Pluripotent Stem Cells. Int J Mol Sci. 2021 Feb 20;22(4):2092. doi: 10.3390/ijms22042092. PMID:33672445 PMCID:PMC7923278
- Asami M, Lam BYH, Ma MK, Rainbow K, Braun S, VerMilyea MD, Yeo GSH, Perry ACF. Human embryonic genome activation initiates at the one-cell stage. Cell Stem Cell. 2021 Dec 17;S1934-5909(21)00484-7. doi: 10.1016/j.stem.2021.11.012. PMID:34936886
- Ayer A, Fazakerley DJ, James DE, Stocker R. The role of mitochondrial reactive oxygen species in insulin resistance. Free Radic Biol Med. 2021 Nov 11:S0891-5849(21)00794-2. doi: 10.1016/j.freeradbiomed.2021.11.007. PMID:34775001
- Ayer A, Fazakerley DJ, Suarna C, Maghzal GJ, Sheipouri D, Lee KJ, Bradley MC, Fernández-Del-Rio L, Tumanov S, Kong SM, van der Veen JN, Yang A, Ho JWK, Clarke SG, James DE, Dawes IW, Vance DE, Clarke CF, Jacobs RL, Stocker R. Genetic screening reveals phospholipid metabolism as a key regulator of the biosynthesis of the redox-active lipid coenzyme Q. Redox Biol. 2021 Sep 8;46:102127. doi: 10.1016/j.redox.2021.102127. PMID:34521065 PMCID:PMC8435697
- Azzu V, Vacca M, Kamzolas I, Hall Z, Leslie J, Carobbio S, Virtue S, Virtue S, Davies SE, Lukasik A, Dale M, Bohlooly-Y M, Acharjee A, Linden D, Bidault G, Petsalaki E, Griffin JL, Oakley F, Allison ME, Vidal-Puig A. Suppression of insulin-induced gene 1 (INSIG1) function promotes hepatic lipid remodelling and restrains NASH progression. Mol Metab. 2021 Mar 12:101210. doi: 10.1016/jmolmet.2021.101210. PMID:33722690
- Bashari WA, Senanayake R, MacFarlane J, Gillett D, Powlson AS, Kolias A, Mannion RJ, Koulouri O, Gurnell M. Using Molecular Imaging to Enhance Decision Making in the Management of Pituitary Adenomas. J Nucl Med. 2021 Jul;62(Suppl 2):57S-62S. doi: 10.2967/jnumed.120.251546. PMID:34230075
- Beardsall K, Thomson L, Guy C, Bond S, Allison A, Pantaleo B, Petrou S, Kim S, Dunger D, Hovorka R. Continuous glucose monitoring in extremely preterm infants in intensive care: the REACT RCT and pilot study of ‘closed-loop’ technology. Southampton (UK): NIHR Journals Library; 2021 Oct. PMID:34723449
- Beardsall K, Thomason L, Guy C, Iglesias-Platas I, van Weissenbruch MM, Bond S, Allison A, Kim S, Petrou S, Pantaleo B, Hovorka R, Dunger D; REACT collaborative. Real-time continuous glucose monitoring in preterm infants (REACT): an international, open-label, randomised controlled trial. Lancet Child Adolesc Health. 2021 Feb 9:S2352-4642(20)30367-9. doi: 10.1016/S2352(20)30367-9. PMID:33577770
- Bidault G, Virtue S, Petkevicius K, Jolin HE, Dugourd A, Guénantin AC, Leggat J, Mahler-Araujo B, Lam BYH, Ma MK, Dale M, Carobbio S, Kaser A, Fallon PG, Saez-Rodriguez J, McKenzie ANJ, Vidal-Puig A. SREBP1-induced fatty acid synthesis depletes macrophages antioxidant defences to promote their alternative activation. Nat Metab. 2021 Sep 16. doi: 10.1038/s42255-021-00440-5. PMID:34531575
- Biglari N, Gaziano I, Schumacher J, Radermacher J, Paeger L, Klemm P, Chen W, Corneliussen S, Wunderlich CM, Sue M, Vollmar S, Klöckener T, Sotelo-Hitschfeld T, Abbasloo A, Edenhofer F, Reimann F, Gribble FM, Fenselau H, Kloppenburg P, Wunderlich FT, Brüning JC. Functionally distinct POMC-expressing neuron subpopulations in hypothalamus revealed by intersectional targeting. Nat Neurosci. 2021 May 17. doi: 10.1038/s41593-021-00854-0. PMID:34002087
- Billing LJ, Larraufie P, Lewis J, Leiter A, Li J, Lam B, Yeo GS, Goldspink DA, Kay RG, Gribble FM, Reimann F. Corrigendum to single cell transcriptomic profiling of large intestinal enteroendocrine cells in mice – Identification of selective stimuli for insulin-like peptide-5 and glucagon-like peptide-1 co-expressing cells (Molecular metabolism. 2019 Nov;29:158-169). Mol Metab. 2022 Jan;55:101399. doi: 10.1016/j.molmet.2021.101399. PMID:34863700 PMCID:PMC8766775
- Bertozzi TM, Becker JL, Blake GET, Bansal A, Nguyen DK, Fernandez-Twinn DS, Ozanne SE, Bartolomei MS, Simmons RA, Watson ED, Ferguson-Smith AC. Variably methylated retrotransposons are refractory to a range of environmental perturbations. Nat Genet. 2021 Aug;53(8):1233-1242. doi: 10.1038/s41588-021-00898-9. PMID:34326545
- Boughton CK, Daly A, Thabit H, Hartnell S, Herzig D, Vogt A, Ruan Y, Wilinska ME, Evans ML, Coll AP, Bally L, Hovorka R. Day-to-day variability of insulin requirements in the inpatient setting: observations during fully closed-loop insulin delivery. Diabetes Obes Metab. 2021 Apr 6. doi: 10.1111/dom.14396. PMID33822461
- Boughton CK, Hartnell S, Thabit H, Poettler T, Herzig D, Wilinska ME, Ashcroft NL, Sibayan J, Cohen N, Calhoun P, Bally L, Mader JK, Evans M, Leelarathna L, Hovorka R. Hybrid closed-loop glucose control with faster insulin aspart (Fiasp) compared with standard insulin aspart in adults with type 1 diabetes: a double-blind, multicentre, multinational, randomised, crossover study. Diabetes Obes Metab. 2021 Feb 19. doi:10.1111/dom.14355. PMID:33606901
- Boughton CK, Hovorka R. Correction to: New closed-loop insulin systems. Diabetologia. 2021 Mar 22. doi: 10.1007/s00125-021-05443-1. PMID:33751132
- Boughton CK, Hovorka R. Can exenatide flatten the post-prandial glucose curve in type 1 diabetes? Ann Transl Med. 2020 Nov;8(22):1535. doi: 10.21037/atm-20-3654. PMID:33313280 PMCID:PMC7729374
- Boughton CK, Hovorka R. New closed-loop insulin systems. Diabetologia. 2021 Feb 6. doi: 10.1007/s00125-021-05391-w. PMID:33550442
- Boughton CK, Tripyla A, Hartnell S, Daly A, Herzig D, Wilinska ME, Czerlau C, Fry A, Bally L, Hovorka R. Fully automated closed-loop glucose control compared with standard insulin therapy in adults with type 2 diabetes requiring dialysis: an open-label, randomized crossover trial. Nat Med. 2021 Aug;27(8):1471-1476. doi: 10.1038/s41591-021-01453-z. PMID:34349267 PMCID:PMC8363503
- Boughton CK, Tripyla A, Hartnell S, Daly A, Herzig D, Wilinska ME, Czerlau C, Fry A, Bally L, Hovorka R. Publisher Correction: Fully automated closed-loop glucose control compared with standard insulin therapy in adults with type 2 diabetes requiring dialysis: an open-label, randomized crossover trial. Nat Med. 2021 Sep 16. doi: 10.1038/s41591-021-01504-5. PMID:34531573
- Bowker N, Hansford R, Burgess S, Foley CN, Auyeung VPW, Erzurumluoglu AM, Stewart ID, Wheeler E, Pietzner M, Gribble F, Reimann F, Bhatnagar P, Coghlan MP, Wareham NJ, Langenberg C. Genetically Predicted Glucose-Dependent Insulinotropic Polypeptide (Gip) Levels and Cardiovascular Disease Risk are Driven by Distinct Causal Variants in the Gipr Region. Diabetes. 2021 Aug 23:db210103. doi: 10.2337/db21-0103. PMID:34426508
- Brierley DI, Holt MK, Singh A, de Araujo A, McDougle M, Vergara M, Afaghani MH, Lee SJ, Scott K, Maske C, Langhans W, Krause E, de Kloet A, Gribble FM, Reimann F, Rinaman L, de Lartigue G, Trapp S. Central and peripheral GLP-1 systems independently suppress eating. Nat Metab. 2021 Feb;3(2):258-273. doi: 10.1038/s42255-021-00344-4. PMID: 33589843 PMCID:PMC7116821
- Brocklebank LA, Blackwell AKM, Marteau TM, Hollands GJ, Fletcher PC, De-Loyde K, Morris RW, Pilling MA, Pechey R, Maynard OM, Attwood AS, Munafò MR. Straight-sided beer and cider glasses to reduce alcohol sales for on-site consumption: A randomised crossover trial in bars. Soc Sci Med. 2021 Jun;278:113911.doi:10.1016/j.socscimed.2021.113911. PMID:33962320 PMCID:PMC8146727
- Brouwers B, Mendes de Oliveira E, Marti-Solano M, Monteiro FBF, Laurin SA, Keogh JM, Henning E, Bounds R, Daly CA, Houston S, Ayinampudi V, Wasiluk N, Clarke D, Plouffe B, Bouvier M, Babu MM, Farooqi IS, Mokrosiński J. Human MC4R variants affect endocytosis, trafficking and dimerization revealing multiple cellularmechanisms involved in weight regulation. Cell Reports, 23 March 2021, 34, 108862. PMID: 33761344 PMCID:PMC7994375
- Buecker C, Merkle FT. Science shines in a new virtual SY-Stem. Development. 2021 Jun 15;148(12):dev188367. doi: 10.1242/dev.188367. PMID:34170290
- Burke LK, Darwish T, Cavanaugh AR, Virtue S, Roth E, Morro J, Liu SM, Xia J, Dalley JW, Burling K, Chua S, Vidal-Puig T, Schwartz GJ, Blouet C. mTORC1 in AGRP neurons integrates exteroceptive and interoceptive food-related cues in the modulation of adaptive energy expenditure in mice. Elife. 2017 May 23;6:e22848. doi: 10.7554/eLife.22848. PMID:28532548 PMCID:PMC5441868
- Camm EJ, Cross CM, Kane AD, Tarry-Adkins JL, Ozanne SE, Giussani DA. Maternal antioxidant treatment protects adult offspring against memory loss and hippocampal atrophy in a rodent model of developmental hypoxia. FASEB J. 2021 May;35(5):e21477. doi: 10.1096/fj.202002557RR. PMID:33891326
- Carobbio S, Guenantin AC, Bahri M, Rodriguez-Fdez S, Hong F Kamzolas I, Samuelson I, Lond K, Awad S, Lukovic D, Erceg S, Bassett A, Mendjan S, Vallier L, Rosen BS, Chiarugi D, Vidal-Puig A. Unravelling the development roadmap towards human brown adipose tissue. Stem Cell Reports. 2021 Feb 6;S2213 6711(21)00043-6. doi: 10.1016/j.stemcr.2021.01.013. PMID:33606988 PMCID:PMC7940445
- Chen NS, Boughton CK, Hartnell S, Fuchs J, Allen JM, Willinska ME, Thankamony A, de Beaufort C, Campbell FM, Fröhlich-Reiterer E, Hofer SE, Kapellen TM, Rami-Merhar B, Ghatak A, Randell TL, Besser REJ, Elleri D, Trevelyan N, Denvir L, Davis N, Gurnell E, Lindsay R, Morris D, Scott EM, Bally L, Thabit H, Leelarathna L, Evans ML, Murphy HR, Mader JK, Hovorka R; AiDAPT, AP@home04, CLOuD, DAN05, DAN06, and KidsAP consortia. User Engagement With the CamAPS FX Hybrid Closed-Loop App According to Age and User Characteristics. Diabetes Care. 2021 May 21;dc202762. doi: 10.2337/dc20-2762. PMID:34021021
- Chen W, Tumanov S, Fazakerley DJ, Cantley J, James DE, Dunn LL, Shaik T, Suarna C, Stocker R. Bilirubin deficiency renders mice susceptible to hepatic steatosis in the absence of insulin resistance. Redox Biol. 2021 Nov;47:102152. doi: 10.1016/j.redox.2021.102152. PMID:34610553 PMCID:PMC8498001
- Choi RJ, Mohamad Zobir SZ, Alexander-Dann B, Sharma N, Ma MKL, Lam BYH, Yeo GSH, Zhang W, Fan TP, Bender A. Combination of Ginsenosides Rb2 and Rg3 Promotes Angiogenic Phenotype of Human Endothelial Cells via PI3K/Akt and MAPK/ERK Pathways. Front Pharmacol. 2021 Feb 10;12:618773. doi: 10.3389/fphar.2021.618773. PMID:33643049 PMCID:PMC7902932
- Chondronikola M, Bartelt A, Vidal-Puig A, Virtanen KA. Editorial: Brown Adipose Tissue: From Heat Production in Rodents to Metabolic Health in Humans. Front Endocrinol (Lausanne). 2021 Jul 26;12:739065. doi: 10.3389/fendo.2021.739065. eCollection 2021. PMID:34381425 PMCID:PMC8350568
- Cimino I, Kim H, Tung YCL, Pedersen K, Rimmington D, Tadross JA, Kohnke SN, Neves-Costa A, Barros A, Joaquim S, Bennett D, Melvin A, Lockhart SM, Rostron AJ, Scott J, Liu H, Burling K, Barker P, Clatworthy MR, Lee EC, Simpson AJ, Yeo GSH, Moita LF, Bence KK, Jørgensen SB, Coll AP, Breen DM, O’Rahilly S. Activation of the hypothalamic-pituitary-adrenal axis by exogenous and endogenous GDF15. Proc Natl Acad Sci U S A. 2021 Jul 6;118(27):e2106868118. doi: 10.1073/pnas.2106868118. PMID:34187898 PMCID:PMC8271778
- Cimino I, Rimmington D, Tung YCL, Lawler K, Larraufie P, Kay RG, Virtue S, Lam BYH, Fagnocchi L, Ma MKL, Saudek V, Zvetkova I, Vidal-Puig A, Yeo GSH, Farooqi IS, Pospisilik JA, Gribble FM, Reimann F, O’Rahilly S, Coll AP. Murine neuronatin deficiency is associated with a hypervariable food intake and bimodal obesity. Sci Rep. 2021 Sep 2;11(1):17571. doi: 10.1038/s41598-021-96278-8. PMID:34475432 PMCID:PMC8413370
- Corrales P, Vidal-Puig A, Medina-Gómez G. Obesity and pregnancy, the perfect metabolic storm. Eur J Clin Nutr. 2021 Apr 28. doi: 10.1038/s41430-021-00914-5. PMID:33911209
- Daly A, Hovorka R. Technology in the management of type 2 diabetes: Present status and future prospects. Diabetes Obes Metab. 2021 May 5. doi: 10.1111/dom.14418. PMID:33950566
- de Beaufort C, Pit-Ten Cate IM, Schierloh U, Cohen N, Boughton CK, Tauschmann M, Allen JM, Nagl K, Fritsch M, Yong J, Metcalfe E, Schaeffer D, Fichelle M, Thiele AG, Abt D, Faninger K, Mader JK, Slegtenhorst S, Ashcroft N, Wilinska ME, Sibayan J, Kollman C, Hofer SE, Fröhlich-Reiterer E, Kapellen TM, Acerini CL, Campbell F, Rami-Merhar B, Hovorka R. Psychological Well-Being of Parents of Very Young Children With Type 1 Diabetes – Baseline Assessment. Front Endocrinol (Lausanne). 2021 Aug 12;12:721028. doi: 10.3389/fendo.2021.721028. eCollection 2021. PMID:34456876 PMCID:PMC8397439
- Dennison RA, Meek CL, Usher-Smith JA, Fox RA, Aiken CE, Griffin SJ. ‘Oh, I’ve got an appointment’: A qualitative interview study exploring how to support attendance at diabetes screening after gestational diabetes. Diabet Med. 2021 Oct;38(10):e14650. doi: 10.1111/dme.14650. PMID:34268798
- Di Cicco E, Moran C, Visser WE, Nappi A, Schoenmakers E, Todd P, Lyons G, Dattani M, Ambrosio R, Parisi S, Salvatore D, Chatterjee VK, Dentice M. Germ line mutations in the thyroid hormone receptor alpha gene predispose to cutaneous tags and melanocytic nevi. Thyroid. 2021 Jan 28. doi: 10.1089/thy.2020.0391. PMID:33509032
- Ding Q, Edwards MM, Wang N, Zhu X, Bracci AN, Hulke ML, Hu Y, Tong Y, Hsiao J, Charvet CJ, Ghosh S, Handsaker RE, Eggan K, Merkle FT, Gerhardt J, Egli D, Clark AG, Koren A. The genetic architecture of DNA replication timing in human pluripotent stem cells. Nat Commun. 2021 Nov 19;12(1):6746. doi: 10.1038/s41467-021-27115-9. PMID:34799581
- Dolezalova N, Gruszczyk A, Barkan K, Gamble JA, Galvin S, Moreth T, O’Holleran K, Mahbubani KT, Higgins JA, Gribble FM, Reimann F, Surmacki J, Andrews S, Casey JJ, Pampaloni F, Murphy MP, Ladds G, Slater NKH, Saeb-Parsy K. Accelerating cryoprotectant diffusion kinetics improves cryopreservation of pancreatic islets. Sci Rep. 2021 May 17;11(1):10418. doi: 10.1038/s41598-021-89853-6. PMID:34001961 PMCID:PMC8129116
- Dowsett GKC, Lam BYH, Tadross JA, Cimino I, Rimmington D, Coll AP, Polex-Wolf J, Knudsen LB, Pyke C, Yeo GSH. A survey of the mouse hindbrain in the fed and fasted state using single-nucleus RNA sequencing. Mol Metab. 2021 May 4;101240. doi: 10.1016/j.molmet.2021.101240. PMID:33962048
- Durgia H, Nicholas AK, Schoenmakers E, Dickens JA, Halanaik D, Sahoo J, Kamalanathan S, Schoenmakers N. Brief Report: A Novel Sodium/Iodide Symporter Mutation, S356F, Causing Congenital Hypothyroidism. Thyroid. 2021 Nov 22. doi: 10.1089/thy.2021.0478. PMID:34806438
- Fabricius TW, Verhulst CEM, Kristensen PL, Tack CJ, McCrimmon RJ, Heller S, Evans ML, Amiel SA, Pieber TR, de Galan BE, Pedersen-Bjergaard U; Hypo-RESOLVE consortium. Hyperinsulinaemic-hypoglycaemic glucose clamps in human research: a systematic review of the literature. Diabetologia. 2021 Feb 10. doi: 10.1007/s00125-020-05361-8. PMID:33566134
- Farooqi IS. Monogenic human obesity syndromes. Handb Clin Neurol. 2021;181:301-310. doi: 10.1016/B978-0-12-820683-6.00022-1. PMID:34238466
- Finnemann JJS, Plaisted-Grant K, Moore J, Teufel C, Fletcher PC. Low-level, prediction-based sensory and motor processes are unimpaired in Autism. Neuropsychologia. 2021 Mar 29;156:107835. doi: 10.1016/j.neuropsychologia.2021.107835. PMID:33794277
- Foreman RE, George AL, Reimann F, Gribble FM, Kay RG. Peptidomics: A Review of Clinical Applications and Methodologies. J Proteome Res. 2021 Jul 16. doi: 10.1021/acs.jproteome.1c00295. PMID:34270237
- Fox RA, Patient CJ, Aiken AR, Meek CL, Aiken CE. Temporal variations in maternal treatment requirements and early neonatal outcomes in patients with gestational diabetes. Diabet Med. 2021 May 8:e14596. doi: 10.1111/dme.14596. PMID:33963609
- Fuchs J, Allen JM, Boughton CK, Wilinska ME, Thankamony A, de Beaufort C, Campbell F, Yong J, Froehlich-Reiterer E, Mader JK, Hofer SE, Kapellen TM, Rami-Merhar B, Tauschmann M, Hood K, Kimbell B, Lawton J, Roze S, Sibayan J, Cohen N, Hovorka R; KidsAP Consortium. Assessing the efficacy, safety and utility of closed-loop insulin delivery compared with sensor-augmented pump therapy in very young children with type 1 diabetes (KidsAP02 study): an open-label, multicentre, multinational, randomised cross-over study protocol. BMJ Open. 2021 Feb 12;11(2):e042790. doi: 10.1136/bmjopen-2020-042790. PMID: 33579766 PMC7883854
- Fuchs J, Hovorka R. Benefits and Challenges of Current Closed-Loop Technologies in Children and Young People With Type 1 Diabetes. Front Pediatr. 2021 Apr 30;9:679484. doi: 10.3389/fped.2021.679484. eCollection 2021. Front Pediatr. 2021 Apr 30;9:679484. doi: 10.3389/fped.2021.679484. PMID:33996702 PMCID:PMC8119627
- Furse S, Fernandez-Twinn DS, Chiarugi D, Koulman A, Ozanne SE. Lipid Metabolism Is Dysregulated before, during and after Pregnancy in a Mouse Model of Gestational Diabetes. Int J Mol Sci. 2021 Jul 12;22(14):7452. doi: 10.3390/ijms22147452. PMID:34299070
- Furse S, Watkins AJ, Hojat N, Smith J, Williams HEL, Chiarugi D, Koulman A. Lipid Traffic Analysis reveals the impact of high paternal carbohydrate intake on offsprings’ lipid metabolism. Commun Biol. 2021 Feb 5;4(1):163. doi: 10.1038/s42003-021-01686-1. PMID:33547386 PMCID:PMC7864968
- Furse S, Williams HEL, Watkins AJ, Virtue S, Vidal-Puig A, Amarsi R, Charalambous M, Koulman A. A pipeline for making 31 P NMR accessible for small- and large-scale lipidomics studies. Anal Bioanal Chem. 2021 Jul 12. doi: 10.1007/s00216-021-03430-4. PMID:34254158
- Gage MC, Harrington D, Brierley GV, Freathy RM, Gabriel BM, Gibson R, McNeilly AD, Meek CL, Roberts LD. Challenges and solutions for diabetes early career researchers in the COVID-19 recovery: Perspectives of the Diabetes UK Innovators in Diabetes. Diabet Med. 2021 Sep 25;e14698. doi: 10.1111/dme.14698. PMID:34562338
- Gallant J, Chan K, Green TJ, Wieringa FT, Leemaqz S, Ngik R, Measelle JR, Baldwin DA, Borath M, Sophonneary P, Yelland LN, Hampel D, Shahab-Ferdows S, Allen LH, Jones KS, Koulman A, Parkington DA, Meadows SR, Kroeun H, Whitfield KC. Low-dose thiamine supplementation of lactating Cambodian mothers improves human milk thiamine concentrations: a randomized controlled trial. Am J Clin Nutr. 2021 Apr 7;nqab052. doi: 10.1093/ajcn/nqab052. PMID:33829271
- Galvin SG, Kay RG, Foreman R, Larraufie P, Meek CL, Biggs E, Ravn P, Jermutus L, Reimann F, Gribble FM. The Human and Mouse Islet Peptidome: Effects of Obesity and Type 2 Diabetes, and Assessment of Intraislet Production of Glucagon-like Peptide-1. J Proteome Res. 2021 Sep 3;20(9):4507-4517. doi: 10.1021/acs.jproteome.1c00463. Epub 2021 Aug 23. PMID:34423991 PMCID:PMC8419866
- Galvin SG, Larraufie P, Kay RG, Pitt H, Bernard E, McGavigan AK, Brandt H, Hood J, Sheldrake L, Conder S, Atherton-Kemp D, Lu VB, O’Flaherty EAA, Roberts GP, Ämmälä C, Jermutus L, Baker D, Gribble FM, Reimann F. Peptidomics of enteroendocrine cells and characterisation of potential effects of a novel preprogastrin derived-peptide on glucose tolerance in lean mice. Peptides. 2021 Mar 17:170532. doi: 10.1016/j.peptides.2021.170532. PMID:33744371
- Gao M, Piernas C, Astbury NM, Hippisley-Cox J, O’Rahilly S, Aveyard P, Jebb SA. Associations between body-mass index and COVID-19 severity in 6·9 million people in England: a prospective, community-based, cohort study. Lancet Diabetes Endocrinol. 2021 Jun;9(6):350-359. doi: 10.1016/S2213-8587(21)00089-9. PMID:33932335 PMCID:PMC8081400
- Gillett D, Bashari W, Senanayake R, Marsden D, Koulouri O, MacFarlane J, van der Meulen M, Powlson AS, Mendichovszky IA, Cheow H, Bird N, Kolias A, Mannion R, Gurnell M. Methods of 3D printing models of pituitary tumors. 3D Print Med. 2021 Aug 31;7(1):24. doi: 10.1186/s41205-021-00118-4. PMID:34462823 PMCID:PMC8406959
- Gillett D, Marsden D, Ballout S, Attili B, Bird N, Heard S, Gurnell M, Mendichovszky IA, Aloj L. 3D printing 18 F radioactive phantoms for PET imaging. EJNMMI Phys. 2021 Apr 28;8(1):38. doi: 10.1186/s40658-021-00383-6. PMID:33909154 PMCID:PMC8081805
- Gonzales GB, Brals D, Sonko B, Sosseh F, Prentice AM, Moore SE, Koulman A. Plasma lipids and growth faltering: A longitudinal cohort study in rural Gambian children. Sci Adv. 2021 Sep 17;7(38):eabj1132. doi: 10.1126/sciadv.abj1132. PMID:34533992
- Gribble FM, O’Rahilly S. Obesity therapeutics: The end of the beginning. Cell Metab 2021;33:705-706. doi: 10.1016/j.cmet.2021.03.012. PMID:33826913
- Gribble FM, Reimann F. Metabolic Messengers: glucagon-like peptide 1. Nat Metab. 2021 Feb;3(2):142-148. doi: 10.1038/s42255-020-00327-x. PMID: 33432200
- Gurnell M, Heaney LG, Price D, Menzies-Gow A. Long-term corticosteroid use, adrenal insufficiency, and the need for steroid-sparing treatment in adult severe asthma. J Intern Med. 2021 Feb 17. doi: 10.1111/joim.13273. PMID:33598993
- Guest PC, Ozanne SE. The Worldwide Effort to Develop Vaccines for COVID-19. Adv Exp Med Biol. 2021;1327:215-223. doi: 10.1007/978-3-030-71697-4_18. PMID:34279842
- Gupta D, Dowsett GKC, Mani BK, Shankar K, Osborne-Lawrence S, Metzger NP, Lam BYH, Yeo GSH, Zigman JM. High co-expression of the ghrelin and LEAP2 receptor GHSR with pancreatic polypeptide in mouse and human islets. Endocrinology. 2021 Jul 21:bqab148. doi: 10.1210/endocr/bqab148. PMID:34289060
- Hamed MO, Barlow AD, Dolezalova N, Khosla S, Sagar A, Gribble FM, Davies S, Murphy MP, Hosgood SA, Nicholson ML, Saeb-Parsy K. Ex vivo normothermic perfusion of isolated segmental porcine bowel: a novel functional model of the small intestine. BJS Open. 2021 Mar 5;5(2):zrab009. doi: 10.1093/bjsopen/zrab009. PMID:33839750 PMCID:PMC8038264
- Harding EC, Ba W, Zahir R, Yu X, Yustos R, Hsieh B, Lignos L, Vyssotski AL, Merkle FT, Constandinou TG, Franks NP, Wisden W. Nitric Oxide Synthase Neurons in the Preoptic Hypothalamus Are NREM and REM Sleep-Active and Lower Body Temperature. Front Neurosci. 2021 Oct 14;15:709825. doi: 10.3389/fnins.2021.709825. PMID:34720852 PMCID:PMC8551479
- Harno E, Sefton C, Wray JR, Allen TJ, Davies A, Coll AP, White A. Chronic glucocorticoid treatment induces hepatic lipid accumulation and hyperinsulinaemia in part through actions on AgRP neurons. Sci Rep. 2021 Jul 2;11(1):13776. doi: 10.1038/s41598-021-93378-3. PMID:34215821 PMCID:PMC8253818
- Harshfield EL, Fauman EB, Stacey D, Paul DS, Ziemek D, Ong RMY, Danesh J, Butterworth AS, Rasheed A, Sattar T, Zameer-Ul-Asar, Saleem I, Hina Z, Ishtiaq U, Qamar N, Mallick NH, Yaqub Z, Saghir T, Rizvi SNH, Memon A, Ishaq M, Rasheed SZ, Memon FU, Jalal A, Abbas S, Frossard P, Saleheen D, Wood AM, Griffin JL, Koulman A. Genome-wide analysis of blood lipid metabolites in over 5000 South Asians reveals biological insights at cardiometabolic disease loci. BMC Med. 2021 Sep 10;19(1):232. doi: 10.1186/s12916-021-02087-1. PMID:34503513 PMCID:PMC8431908
- Heeley N, Kirwan P, Darwish T, Arnaud M, Evans ML, Merkle FT, Reimann F, Gribble FM, Blouet C. Rapid sensing of l-leucine by human and murine hypothalamic neurons: Neurochemical and mechanistic insights. Mol Metab. 2018 Apr;10:14-27. doi: 10.1016/j.molmet.2018.01.021. PMID29439854 PMCID:PMC5985239
- Ho K, Fleseriu M, Kaiser U, Salvatori R, Brue T, Lopes MB, Kunz P, Molitch M, Camper SA, Gadelha M, Syro LV, Laws E, Reincke M, Nishioka H, Grossman A, Barkan A, Casanueva F, Wass J, Mamelak A, Katznelson L, van der Lely AJ, Radovick S, Bidlingmaier M, Boguszewski M, Bollerslev J, Hoffman AR, Oyesiku N, Raverot G, Ben-Shlomo A, Fowkes R, Shimon I, Fukuoka H, Pereira AM, Greenman Y, Heaney AP, Gurnell M, Johannsson G, Osamura RY, Buchfelder M, Zatelli MC, Korbonits M, Chanson P, Biermasz N, Clemmons DR, Karavitaki N, Bronstein MD, Trainer P, Melmed S. Pituitary Neoplasm Nomenclature Workshop: Does Adenoma Stand the Test of Time? J Endocr Soc. 2021 Feb 9;5(3):bvaa205. doi: 10.1210/jendso/bvaa205. PMID:33604494 PMCID:PMC7874572
- Hornigold DC, Roth E, Howard V, Will S, Oldham S, Coghlan MP, Blouet C, Trevaskis JL. A GLP-1:CCK fusion peptide harnesses the synergistic effects on metabolism of CCK-1 and GLP-1 receptor agonism in mice. Appetite. 2018 Aug 1;127:334-340. doi: 10.1016/j.appet.2018.05.131. PMID:29782892 PMCID:PMC6026274
- Huang, F.-Y., Sutcliffe, M.P.F. and Grabenhorst, F. (2021). Preferences for nutrients and sensory food qualities identify biological sources of economic values in monkeys. Proc Natl Acad Sci USA. 118(26): e2101954118. doi: 10.1073/pnas.2101954118. PMID: 34155111
- Huang-Doran I, Kinzer AB, Jimenez-Linan M, Thackray K, Harris J, Adams CL, de Kerdanet M, Stears A, O’Rahilly S, Savage DB, Gorden P, Brown RJ, Semple RK. Ovarian hyperandrogenism and its response to gonadotropin-releasing hormone analogue therapy in primary severe insulin resistance. J Clin Endocrinol Metab. 2021 Apr 26:dgab275. doi: 10.1210/clinem/dgab275. PMID:33901270
- Huang FY, Sutcliffe MPF, Grabenhorst F. Preferences for nutrients and sensory food qualities identify biological sources of economic values in monkeys. Proc Natl Acad Sci U S A. 2021 Jun 29;118(26):e2101954118. doi: 10.1073/pnas.2101954118. PMID:34155111 PMCID:PMC8255786
- Huang LO, Rauch A, Mazzaferro E, Preuss M, Carobbio S, Bayrak CS, Chami N, Wang Z, Schick UM, Yang N, Itan Y, Vidal-Puig A, den Hoed M, Mandrup S, Kilpeläinen TO, Loos RJF. Genome-wide discovery of genetic loci that uncouple excess adiposity from its comorbidities. Nat Metab. 2021 Feb;3(2):228-243. doi: 10.1038/s42255-021-00346-2. PMID:33619380
- Hufnagel A, Fernandez-Twinn DS, Blackmore HL, Ashmore TJ, Heaton RA, Jenkins B, Koulman A, Hargreaves IP, Aiken CE, Ozanne SE. Maternal but not fetoplacental health can be improved by metformin in a murine diet-induced model of maternal obesity and glucose intolerance. Physiol. 2021 Sep 10. doi: 10.1113/JP281902. PMID:34505282
- Im YR, Hunter H, de Gracia Hahn D, Duret A, Cheah Q, Dong J, Fairey M, Hjalmarsson C, Li A, Kai Lim H, McKeown L, Mitrofan CG, Rao R, Utukuri M, Rowe IA, Mann JP. A systematic review of animal models of NAFLD finds high fat, high fructose diets most closely resemble human NAFLD. Hepatology. 2021 May 11. doi: 10.1002/hep.31897. PMID:33973269
- Jerber J, Seaton DD, Cuomo ASE, Kumasaka N, Haldane J, Steer J, Patel M, Pearce D, Andersson M, Bonder MJ, Mountjoy E, Ghoussaini M, Lancaster MA; HipSci Consortium, Marioni JC, Merkle FT, Gaffney DJ, Stegle O. Population-scale single-cell RNA-seq profiling across dopaminergic neuron differentiation. Nat Genet. 2021 Mar;53(3):304-312. doi: 10.1038/s41588-021-00801-6. PMID:33664506
- Johnson K, Leary PJ, Govaere O, Barter MJ, Charlton SH, Cockell SJ, Tiniakos D, Zatorska M, Bedossa P, Brosnan MJ, Cobbold JF, Ekstedt M, Aithal GP, Clément K, Schattenberg JM, Boursier J, Ratziu V, Bugianesi E, Anstee QM, Daly AK; LITMUS Consortium Investigators. Increased serum miR-193a-5p during non-alcoholic fatty liver disease progression: Diagnostic and mechanistic relevance. JHEP Rep. 2021 Nov 25;4(2):100409. doi: 10.1016/j.jhepr.2021.100409. PMID:35072021 PMCID:PMC8762473
- Jones D, De Lucia Rolfe E, Rennie KL, Griep LMO, Kusinski LC, Hughes DJ, Brage S, Ong KK, Beardsall K, Meek CL. Antenatal Determinants of Childhood Obesity in High-Risk Offspring: Protocol for the DiGest Follow-Up Study. Nutrients. 2021 Mar 31;13(4):1156. doi: 10.3390/nu13041156. PMID:33807319 PMC8067255
- Kanakis I, Alameddine M, Folkes L, Moxon S, Myrtziou I, Ozanne SE, Peffers MJ, Goljanek-Whysall K, Vasilaki A. Small-RNA Sequencing Reveals Altered Skeletal Muscle microRNAs and snoRNAs Signatures in Weanling Male Offspring from Mouse Dams Fed a Low Protein Diet during Lactation. Cells. 2021 May 11;10(5):1166. doi: 10.3390/cells10051166. PMID:34064819 PMCID:PMC8150574
- Kanti V, Puder L, Jahnke I, Krabusch PM, Kottner J, Vogt A, Richter C, Andruck A, Lechner L, Poitou C, Krude H, Gottesdiener K, Clément K, Farooqi IS, Wiegand S, Kühnen P, Blume-Peytavi U. A Melanocortin-4 Receptor Agonist Induces Skin and Hair Pigmentation in Patients with Monogenic Mutations in the Leptin-Melanocortin Pathway. Skin Pharmacol Physiol. 2021 May 31:1-10. doi: 10.1159/000516282. PMID:34058738
- Kay RG, Barker P, Burling K, Cohen M, Halsall D, Reimann F, Gribble FM, Semple RK, Church D. Increased C-Peptide Immunoreactivity in Insulin Autoimmune Syndrome (Hirata Disease) Due to High Molecular Weight Proinsulin. Clin Chem. 2021 Jun 1;67(6):854-862. doi: 10.1093/clinchem/hvab043. PMID:34051096 PMCID:PMC8167340
- Kearney AL, Norris DM, Ghomlaghi M, Kin Lok Wong M, Humphrey SJ, Carroll L, Yang G, Cooke KC, Yang P, Geddes TA, Shin S, Fazakerley DJ, Nguyen LK, James DE, Burchfield JG. Akt phosphorylates insulin receptor substrate to limit PI3K-mediated PIP3 synthesis. Elife. 2021 Jul 13;10:e66942. doi: 10.7554/eLife.66942. PMID:34253290 PMCID:PMC8277355
- Kelly MP, Brayne C, Kinmonth AL, Kriznik N, Ford J, Fletcher PC. Inequalities in mental health: predictive processing and social life. Curr Opin Psychiatry. 2021 Mar 1;34(2):171-176. doi: 10.1097/YCO.0000000000000680. PMID:33394729
- Kimbell B, Lawton J, Boughton C, Hovorka R, Rankin D. Parents’ experiences of caring for a young child with type 1 diabetes: a systematic review and synthesis of qualitative evidence. BMC Pediatr. 2021 Apr 4;21(1):160. doi: 10.1186/s12887-021-02569-4. PMID:33814007 PMCID:PMC8019496
- Kohnke S, Buller S, Nuzzaci D, Ridley K, Lam B, Pivonkova H, Bentsen MA, Alonge KM, Zhao C, Tadross J, Holmqvist S, Shimizo T, Hathaway H, Li H, Macklin W, Schwartz MW, Richardson WD, Yeo GSH, Franklin RJM, Karadottir RT, Rowitch DH, Blouet C. Nutritional regulation of oligodendrocyte differentiation regulates perineuronal net remodeling in the median eminence. Cell Rep. 2021 Jul 13;36(2):109362. doi: 10.1016/j.celrep.2021.109362. PMID:34260928 PMCID:PMC8293628
- Koprulu M, Zhao Y, Wheeler E, Dong L, Rocha N, Li C, Griffin JD, Patel S, Van de Streek M, Glastonbury CA, Stewart ID, Felix RD, Luan J, Bowker N, Wittemans LBL, Kerrison ND, Cai L, Lucarelli DME, Barroso I, McCarthy MI, Scott RA, Saudek V, Kerrin SS, Wareham NJ, Semple RK, Perry JRB, O’Rahilly S, Lotta LA, Langenberg C, Savage DB. Identification of rare loss of function genetic variation regulating body fat distribution. J Clin Endocrinol Metab. 2021 Dec 7;dgab877. doi: 10.1210/clinem/dgab877. PMID:34875679
- Kuhre RE, Modvig IM, Jepsen SL, Kizilkaya HS, Bæch-Laursen C, Smith CA, Reimann F, Gribble FM, Rosenkilde MM, Holst JJ. L-Cell Expression of Melanocortin-4-Receptor Is Marginal in Most of the Small Intestine in Mice and Humans and Direct Stimulation of Small Intestinal Melanocortin-4-Receptors in Mice and Rats Does Not Affect GLP-1 Secretion. Front Endocrinol (Lausanne). 2021 Aug 5;12:690387. doi: 10.3389/fendo.2021.690387. eCollection 2021. PMID:34421821 PMCID:PMC8375664
- Lafferty RA, Tanday N, Moffett RC, Reimann F, Gribble FM, Flatt PR, Irwin N. Positive Effects of NPY1 Receptor Activation on Islet Structure Are Driven by Pancreatic Alpha- and Beta-Cell Transdifferentiation in Diabetic Mice. Front Endocrinol (Lausanne). 2021 Feb 25;12:633625. doi: 10.3389/fendo.2021.633625. PMID:33716983 PMCID:PMC7949013
- Lam BYH, Williamson A, Finer S, Day FR, Tadross JA, Gonçalves Soares A, Wade K, Sweeney P, Bedenbaugh MN, Porter DT, Melvin A, Ellacott KLJ, Lippert RN, Buller S, Rosmaninho-Salgado J, Dowsett GKC, Ridley KE, Xy Z, Cimino I, Rimmington D, Rainbow K, Duckett K, Holmqvist S, Khan A, Dai , Bochukova EG; Genes & Health Research Team, Trembath RC, Martin HC, Coll AP, Rowditch DH, Wareham NJ, van Heel DA, Timpson N, Simerly RB, Ong KK, Cone RD, Langenberg C, Perry JRB, Yeo GS, O’Rahilly S. MC3R links nutritional state to childhood growth and the timing of puberty. Nature. 2021 Nov 3. doi: 10.1038/s41586-021-04088-9. Epub ahead of print. PMID: 34732894.
- Lawton J, Hart R, Kimbell B, Allen JM, Besser REJ, Boughton C, Elleri D, Fuchs J, Ghatak A, Randell T, Thankamony A, Trevelyan N, Hovorka R, Rankin D. Data sharing whilst using a closed-loop system: Qualitative study of adolescents’ and parents’ experiences and views. Diabetes Technol Ther. 2021 Feb 19. doi: 10.1089/dia.2020.0637. PMID:33605790
- Leelarathna L, Thabit H, Wilinska ME, Bally L, Mader JK, Pieber TR, Benesch C, Arnolds S, Johnson T, Heinemann L, Hermanns N, Evans ML, Hovorka R. Evaluating Glucose Control With a Novel Composite Continuous Glucose Monitoring Index. J Diabetes Sci Technol. 2020 Mar;14(2):277-283. doi: 10.1177/1932296819838525. PMID: 30931606 PMCID:PMC7196869
- Leggat J, Bidault G, Vidal-Puig A. Lipotoxicity: a driver of heart failure with preserved ejection fraction? Clin Sci (Lond). 2021 Oct 15;135(19):2265-2283. doi: 10.1042/CS20210127. PMID: 34643676
- Li J, Zhang Y, Ye Y, Li D, Liu Y, Lee E, Zhang M, Dai X, Zhang X, Wang S, Zhang J, Jia W, Zen K, Vidal-Puig A, Jiang X, Zhang CY. Pancreatic β cells control glucose homeostasis via the secretion of exosomal miR-29 family. J Extracell Vesicles. 2021 Jan;10(3):e12055. doi: 10.1002/jev2.12055. PMID:33520119 PMCID:PMC7820156
- Liu S, Marcelin G, Blouet C, Jeong JH, Jo YH, Schwartz GJ, Chua S Jr. A gut-brain axis regulating glucose metabolism mediated by bile acids and competitive fibroblast growth factor actions at the hypothalamus. Mol Metab. 2018 Feb;8:37-50. doi: 10.1016/j.molmet.2017.12.003. PMID:29290621 PMCID:PMC5985052
- Lockhart SM, O’Rahilly S. Colchicine-an old dog with new tricks. Nat Metab 2021 doi:10.1038/s42255-021-00360-4.PMID: 33846642
- Loos RJF, Yeo GSH. The genetics of obesity: from discovery to biology. Nat Rev Genet. 2021 Sep 23:1-14. doi: 10.1038/s41576-021-00414-z. PMID:34556834 PMCID:PMC8459824
- Lotta L, Langenberg C, Wareham NJ, Farooqi IS. Reply to Unreliability of genotyping arrays for detecting very rare variants in human genetic studies: Example from a recent study of MC4R. Cell. 2021 Apr 1;184(7):1652-1653. doi: 10.1016/j.cell.2021.03.014. PMID:33798435
- Lotta LA, Pietzner M, Stewart ID, Wittemans LBL, Li C, Bonelli R, Raffler J, Biggs EK, Oliver-Williams C, Auyeung VPW, Luan J, Wheeler E, Paige E, Surendran P, Michelotti GA, Scott RA, Burgess S, Zuber V, Sanderson E, Koulman A, Imamura F, Forouhi NG, Khaw KT; MacTel Consortium, Griffin JL, Wood AM, Kastenmüller G, Danesh J, Butterworth AS, Gribble FM, Reimann F, Bahlo M, Fauman E, Wareham NJ, Langenberg C. A cross-platform approach identifies genetic regulators of human metabolism and health. Nat Genet. 2021 Jan;53(1):54-64. doi: 10.1038/s41588-020-00751-5. Epub 2021 Jan 7. PMID: 33414548.
- Lu VB, Gribble FM, Reimann F. Nutrient-Induced Cellular Mechanisms of Gut Hormone Secretion. Nutrients. 2021 Mar 9;13(3):883. doi: 10.3390/nu13030883. PMID:33803183 PMCID:PMC8000029
- Marcus HJ, Khan DZ, Borg A, Buchfelder M, Cetas JS, Collins JW, Dorward NL, Fleseriu M, Gurnell M, Javadpour M, Jones PS, Koh CH, Layard Horsfall H, Mamelak AN, Mortini P, Muirhead W, Oyesiku NM, Schwartz TH, Sinha S, Stoyanov D, Syro LV, Tsermoulas G, Williams A, Winder MJ, Zada G, Laws ER.Pituitary society expert Delphi consensus: operative workflow in endoscopic transsphenoidal pituitary adenoma resection. Pituitary. 2021 Jul 6:1-15. doi: 10.1007/s11102-021-01162-3. PMID:34231079 PMCID:PMC8259776
- Meek CL, Monitoring motherhood: Monitoring and optimizing glycaemia in women with pre-existing diabetes in pregnancy. Ann Clin Biochem. 2021 Aug 3;45632211035815. doi: 10.1177/00045632211035815. PMID:34260324
- Meek CL. Swings and roundabouts: Time to rethink our approach to gestational diabetes diagnosis? Diabet Med. 2021 May 9;e14597. doi: 10.1111/dme.14597. PMID:33966291
- Meek CL, Corcoy R, Asztalos E, Kusinski LC, López E, Feig DS, Murphy HR; CONCEPTT collaborative group. Which growth standards should be used to identify large- and small-for-gestational age infants of mothers with type 1 diabetes? A pre-specified analysis of the CONCEPTT trial. BMC Pregnancy Childbirth. 2021 Jan 29;21(1):96. doi: 10.1186/s12884-021-03554-6. PMID:3514342 PMCID:PMC7845036
- Meek CL, Oram RA, McDonald TJ, Feig DS, Hattersley AT, Murphy HR; CONCEPTT Collaborative Group. Reappearance of C-Peptide During the Third Trimester of Pregnancy in Type 1 Diabetes: Pancreatic Regeneration or Fetal Hyperinsulinism? Diabetes Care. 2021 Aug;44(8):1826-1834. doi: 10.2337/dc21-0028. PMID:34175829
- Meek CL, Tundidor D, Feig DS, Yamamoto JM, Scott EM, Ma DD, Halperin JA, Murphy HR, Corcoy R; CONCEPTT Collaborative Group. Novel Biochemical Markers of Glycemia to Predict Pregnancy Outcomes in Women With Type 1 Diabetes. Diabetes Care. 2021 Mar;44(3):681-689. doi: 10.2337/dc20-2360. PMID:33495292 PMCID:PMC8051277
- Miedzybrodzka EL, Foreman RE, Lu VB, George AL, Smith CA, Larraufie P, Kay RG, Goldspink DA, Reimann F, Gribble FM. Stimulation of motilin secretion by bile, free fatty acids, and acidification in human duodenal organoids. Mol Metab. 2021 Oct 15;54:101356. doi: 10.1016/j.molmet.2021.101356. PMID:34662713 PMCID:PMC8590067
- Mendes de Oliveira E, Keogh JM, Talbot F, Henning E, Ahmed R, Perdikari A, Bounds R, Wasiluk N, Ayinampudi V, Barroso I, Mokrosiński J, Jyothish D, Lim S, Gupta S, Kershaw M, Matei C, Partha P, Randell T, McAculay A, Wilson LC, Cheetham T, Crowne EC, Clayton P, Farooqi IS. Obesity-Associated GNAS Mutations and the Melanocortin Pathway. New England Journal of Medicine, 2021 Oct 21;385(17):1581-1592. doi: 10.1056/NEJMoa2103329. : 34614324
- Mennitti LV, Carpenter AAM, Loche E, Pantaleão LC, Fernandez-Twinn DS, Schoonejans JM, Blackmore HL, Ashmore TJ, Pisani LP, Tadross JA, Hargreaves I, Ozanne SE. Effects of maternal diet-induced obesity on metabolic disorders and age-associated miRNA expression in the liver of male mouse offspring. Int J Obes (Lond). 2021 Oct 18. doi: 10.1038/s41366-021-00985-1. PMID:34663892
- Menzies-Gow A, Gurnell M, Heaney LG, Corren J, Bel EH, Maspero J, Harrison T, Jackson DJ, Price D, Lugogo N, Kreindler J, Burden A, de Giorgio-Miller A, Padilla K, Martin UJ, Garcia Gil E. Oral corticosteroid elimination via a personalised reduction algorithm in adults with severe, eosinophilic asthma treated with benralizumab (PONENTE): a multicentre, open-label, single-arm study. Lancet Respir Med. 2021 Oct 4;S2213-2600(21)00352-0. doi: 10.1016/S2213-2600(21)00352-0. PMID:34619104
- Menzies-Gow A, Kreindler J, Katial R, Gurnell M. Adrenal insufficiency in patients taking benralizumab as corticosteroid sparing therapy – Authors’ reply. Lancet Respir Med. 2021 Nov 8;S2213-2600(21)00489-6. doi: 10.1016/S2213-2600(21)00489-6. PMID:34762847
- Moore SE, Doel AM, Ong KK, Dunger DB, Affara NA, Prentice AM, Bernstein RM; HERO-G Working Group. Identification of nutritionally modifiable hormonal and epigenetic drivers of positive and negative growth deviance in rural African fetuses and infants: Project protocol and cohort description. Gates Open Res. 2020 Feb 24;4:25. doi: 10.12688/gatesopenres.13101.1. PMID:33693312 PMCID:PMC7921526
- Moran C, McEniery CM, Schoenmakers N, Mitchell C, Sleigh A, Watson L, Lyons G, Burling K, Barker P, Chatterjee K. Dyslipidemia, insulin resistance, ectopic lipid accumulation and vascular function in Resistance to Thyroid Hormone β. J Clin Endocrinol Metab. 2021 Feb 1:dgab002. doi: 10.1210/clinem/dgab002. PMID:33524107
- Mulderrig L, Garaycoechea JI, Tuong ZK, Millington CL, Dingler FA, Ferdinand JR, Gaul L, Tadross JA, Arends MJ, O’Rahilly S, Crossan GP, Clatworthy MR, Patel KJ. Aldehyde-driven transcriptional stress triggers an anorexic DNA damage response. Nature. 2021 Dec;600(7887):158-163. doi: 10.1038/s41586-021-04133-7. PMID:34819667
- Munro APS, Feng S, Janani L, Cornelius V, Aley PK, Babbage G, Baxter D, Bula M, Cathie K, Chatterjee K, Dodd K, Enever Y, Qureshi E, Goodman AL, Green CA, Harndahl L, Haughney J, Hicks A, van der Klaauw AA, Kanji N, Libri V, Llewelyn MJ, McGregor AC, Maallah M, Minassian AM, Moore P, Mughal M, Mujadidi YF, Holliday K, Osanlou O, Osanlou R, Owens DR, Pacurar M, Palfreeman A, Pan D, Rampling T, Regan K, Saich S, Bawa T, Saralaya D, Sharma S, Sheridan R, Thomson EC, Todd S, Twelves C, Read RC, Charlton S, Hallis B, Ramsay M, Andrews N, Lambe T, Nguyen-Van-Tam JS, Snape MD, Liu X, Faust SN; COV-BOOST study group. Safety, immunogenicity and reactogenicity of BNT162b2 and mRNA1273 COVID-19 vaccines given as fourth-dose boosters following two doses of ChAdOx1 nCov-19 or BNT162b2 and a third dose of BNT162b2 (COVBOOST): a multicentre, blinded, phase 2, randomised trial. The Lancet Infectious Diseases (2022) S1473-3099(22)00271-7. doi: 10.1016/S1473-3099(22)00271-7. PMID:35550261 PMCID:PMC9084623
- Munro APS, Jalani L, Cornelius, V, Aley PK, Babbage G, Baxter D, Bula M, Cathie K, Chatterjee K, Dodd K, Enever Y, Gokani K, Goodman A, Green CA, Harndahl L, Haughney J, Hicks A, van der Klaauw A, Kwok J, Libri V, Llewelyn M, McGregor AC, Minassian A, Moore P, Mughal M, Mujadidi YF, Murira J, Osanlou O, Osanlou R, Owens DR, Pacurar M, Palfreeman A, Pan D, Rampling R, Regan K, Saich S, Sakeld J, Saralaya D, Sharma S, Sheridan R, Sturdy A, Thomson EC, Todd S, Twelves C, Read R, Charlton S, Hallis B, Ramsay M, Andrews N, Nguyen-Van-Tam JS, Snape MD, Liu X, Faust SN and the COV-BOOST study group. Safety and immunogenicity of seven COVID-19 vaccines as a third dose (booster) following two doses of ChAdOx1-nCov19 (AZD1222) or BNT162b2: A blinded, randomised controlled trial (COV-BOOST). Lancet (2021). 398(10318):2258-2276. PMID:34863358 PMCID:PMC8639161
- Muzurović E, van der Lely AJ, Gurnell M. AST to ALT Ratio and Peripheral Arterial Disease in a Hypertensive Population-Is There a Link? Angiology. 2021 Mar 24:33197211004387. doi: 10.1177/00033197211004387. PMID:33759592
- Napso T, Zhao X, Lligoña MI, Sandovici I, Kay RG, George AL, Gribble FM, Reimann F, Meek CL, Hamilton RS, Sferruzzi-Perri AN. Placental secretome characterization identifies candidates for pregnancy complications. Commun Biol. 2021 Jun 8;4(1):701. doi: 10.1038/s42003-021-02214-x. PMID:34103657 PMCID:PMC8187406
- Naumenko DJ, Dykes J, O’Connor GK, Stanley Z, Affara N, Doel AM, Drammeh S, Dunger DB, Faal A, Ong KK, Sosseh F, Prentice AM, Moore SE, Bernstein RM. A Novel method for the identification and quantification of weight faltering. Am J Phys Anthropol. 2021 Jan 1. doi: 10.1002/ajpa.24217. PMID:33386624
- Nixon R, Ip THR, Jenkins B, Yip PK, Clarke P, Ponnusamy V, Michael-Titus AT, Koulman A, Shah DK. Lipid Profiles from Dried Blood Spots Reveal Lipidomic Signatures of Newborns Undergoing Mild Therapeutic Hypothermia after Hypoxic-Ischemic Encephalopathy. Nutrients. 2021 Nov 28;13(12):4301. doi: 10.3390/nu13124301. PMID:34959853 PMCID:PMC8703828
- Nizari S, Basalay M, Chapman P, Korte N, Korsak A, Christie IN, Theparambil SM, Davidson SM, Reimann F, Trapp S, Yellon DM, Gourine AV. Glucagon-like peptide-1 (GLP-1) receptor activation dilates cerebral arterioles, increases cerebral blood flow, and mediates remote (pre)conditioning neuroprotection against ischaemic stroke. Basic Res Cardiol. 2021 May 3;116(1):32. doi: 10.1007/s00395-021-00873-9. PMID:33942194 PMCID:PMC8093159
- Nyimanu D, Kay RG, Kuc RE, Brown AJH, Gribble FM, Maguire JJ, Davenport AP. In vitro metabolism of synthetic Elabela/Toddler (ELA-32) peptide in human plasma and kidney homogenates analyzed with mass spectrometry and validation of endogenous peptide quantification in tissues by ELISA. Peptides. 2021 Aug 26;145:170642. doi: 10.1016/j.peptides.2021.170642. PMID:34455010
- Olga L, van Diepen JA, Bobeldijk-Pastorova I, Gross G, Prentice PM, Snowden SG, Furse S, Kooistra T, Hughes IA, Schoemaker MH, van Tol EAF, van Duyvenvoorde W, Wielinga PY, Ong KK, Dunger DB, Kleemann R, Koulman A. Lipid ratios representing SCD1, FADS1, and FADS2 activities as candidate biomarkers of early growth and adiposity. EBioMedicine. 2021 Jan 6;63:103198. doi: 10.1016/j.ebiom.2020.103198. Epub ahead of print. PMID: 33421943; PMCID: PMC7806876.
- Olga L, van Beijsterveldt IALP, Hughes IA, Dunger DB, Ong KK, Hokken-Koelega ACS, De Lucia Rolfe E. Anthropometry-based prediction of body composition in early infancy compared to air-displacement plethysmography. Pediatr Obes. 2021 Jun 10:e12818. doi: 10.1111/ijpo.12818. PMID:34114363
- O’Rahilly S. The islet’s bridesmaid becomes the bride: Proglucagon-derived peptides deliver transformative therapies. Cell 2021:S0092-8674(21)00304-4. doi:10.1016/j.cell.2021.03.019. PMID:33831374
- O’Rahilly S. The islet’s bridesmaid becomes the bride: Proglucagon-derived peptides deliver transformative therapies. Cell. 2021 Jul 22;184(15):4105. doi: 10.1016/j.cell.2021.07.008. PMID:34297931
- O’Rahilly S. “Treasure Your Exceptions”-Studying Human Extreme Phenotypes to Illuminate Metabolic Health and Disease: The 2019 Banting Medal for Scientific Achievement Lecture. Diabetes. 2021 Jan;70(1):29-38. doi: 10.2337/dbi19-0037. PMID:33355307 PMCID:PMC7881844
- Patterson-Cross RB, Levine AJ, Menon V. Selecting single cell clustering parameter values using subsampling-based robustness metrics. BMC Bioinformatics 22, 39. https://doi.org/10.1186/s12859-021-03957-4. PMID:33522897 PMCID:PMC7852188
- Pegram C, Raffan E, White E, Ashworth AH, Brodbelt DC, Church DB, O’Neill DG. Frequency, breed predisposition and demographic risk factors for overweight status in dogs in the UK. J Small Anim Pract. 2021 Mar 23. doi: 10.1111/jsap.13325. PMID:33754373
- Pérez-Sánchez C, Barbarroja N, Pantaleão LC, López-Sánchez LM, Ozanne SE, Jurado-Gámez B, Aranda E, Lopez-Pedrera C, Rodríguez-Ariza A. Clinical Utility of microRNAs in Exhaled Breath Condensate as Biomarkers for Lung Cancer. Pers Med. 2021 Feb 9;11(2):111. doi: 10.3390/jpm11020111. PMID:33572343
- Petkevicius K, Bidault G, Virtue S, Jenkins B, van Dierendonck XAMH, Dugourd A, Saez-Rodriguez J, Stienstra R, Koulman A, Vidal-Puig A. Norepinephrine promotes triglyceride storage in macrophages via beta2-adrenergic receptor activation. FASEB J. 2021 Feb;35(2):e21266. doi: 10.1096/fj.202001101R. PMID: 33484195.
- Petkevicius K, Bidault G, Virtue S, Newland SA, Dale M, Dugourd A, Saez-Rodriguez J, Mallat Z, Vidal-Puig A. Macrophage beta2-adrenergic receptor is dispensable for the adipose tissue inflammation and function. Molecular Metabolism. 2021 Mar 25;48:101220. doi: 10.1016/j.molmet.2021.101220. PMID: 33774223
- Petry CJ, Burling KA, Barker P, Hughes IA, Ong KK, Dunger DB. Pregnancy Serum DLK1 Concentrations are associated with Indices of Insulin Resistance and Secretion. J Clin Endo Metab. 2021 Feb 26;dgab123. doi: 10.1210/clinem/dgab123. PMID:33640968
- Petry CJ, Ong KK, Hughes IA, Dunger DB. Folic acid supplementation during pregnancy and associations with offspring size at birth and adiposity: a cohort study. BMC Res Notes. 2021 Apr 30;14(1):160. doi: 10.1186/s13104-021-05575-y. PMID:33931129 PMCID:PMC8086326
- Pietzner M, Wheeler E, Carrasco-Zanini J, Cortes A, Koprulu M, Wörheide MA, Oerton E, Cook J, Stewart ID, Kerrison ND, Luan J, Raffler J, Arnold M, Arlt W, O’Rahilly S, Kastenmüller G, Gamazon ER, Hingorani AD, Scott RA, Wareham NJ, Langenberg C. Mapping the proteo-genomic convergence of human diseases. Science. 2021 Nov 12;374(6569):eabj1541. doi: 10.1126/science.abj1541. PMID:34648354
- Quarta C, Claret M, Zeltser LM, Williams KW, Yeo GSH, Tschöp MH, Diano S, Brüning JC, Cota D. POMC neuronal heterogeneity in energy balance and beyond: an integrated view. Nat Metab. 2021 Feb 25. doi: 10.1038/s42255-021-00345-3. PMID:33633406
- Quilter CR, Harvey KM, Bauer J, Skinner BM, Gomez M, Shrivastava M, Doel AM, Drammeh S, Dunger DB, Moore SE, Ong KK, Prentice AM, Bernstein RM, Sargent CA, Affara NA. Identification of methylation changes associated with positive and negative growth deviance in Gambian infants using a targeted methyl sequencing approach of genomic DNA. FASEB Bioadv. 2021 Feb 5;3(4):205-230. doi: 10.1096/fba.2020-00101. PMID:33842847. PMCID:PMC8019263
- Quiñones M, Hernández-Bautista R, Beiroa D, Heras V, Torres-Leal FL, Lam BYH, Senra A, Fernø J, Gómez-Valadés AG, Schwaninger M, Prevot V, Yeo G, Claret M, López M, Diéguez C, Al-Massadi O, Nogueiras R. Sirt3 in POMC neurons controls energy balance in a sex- and diet-dependent manner. Redox Biol. 2021 May;41:101945. doi: 10.1016/j.redox.2021.101945. PMID:33744652 PMCID:PMC8005845
- Rankin D, Kimbell B, Allen JM, Besser REJ, Boughton CK, Campbell F, Elleri D, Fuchs J, Ghatak A, Randell T, Thankamony A, Trevelyan N, Wilinska ME, Hovorka R, Lawton J. Adolescents’ Experiences of Using a Smartphone Application Hosting a Closed-loop Algorithm to Manage Type 1 Diabetes in Everyday Life: Qualitative Study. J Diabetes Sci Technol. 2021 Jul 14:1932296821994201. doi: 10.1177/1932296821994201. PMID:34261348
- Rankin D, Kimbell B, Hovorka R, Lawton J. Adolescents’ and their parents’ experiences of using a closed-loop system to manage type 1 diabetes in everyday life: qualitative study. Chronic Illn. 2021 Jan 20:1742395320985924. doi: 10.1177/1742395320985924. PMID:33472409
- Rao S, Yang X, Ohshiro K, Zaidi S, Wang Z, Shetty K, Xiang X, Hassan MI, Mohammad T, Latham PS, Nguyen BN, Wong L, Yu H, Al-Abed Y, Mishra B, Vacca M, Guenigault G, Allison MED, Vidal-Puig A, Benhammou JN, Alvarez M, Pajukanta P, Pisegna JR, Mishra L. β2-spectrin (SPTBN1) as a therapeutic target for diet-induced liver disease and preventing cancer development. Sci Transl Med. 2021 Dec 15;13(624):eabk2267. doi: 10.1126/scitranslmed.abk2267. PMID:34910547
- Robertson TM, Brown JE, Fielding BA, Hovorka R, Robertson MD. Resistant Starch Production and Glucose Release from Pre-Prepared Chilled Food: The SPUD Project. Nutr Bull. 2021 Mar;46(1):52-59. doi: 10.1111/nbu.12476. PMID:33776583 PMCID:PMC7984060
- Rodriguez-Cuenca S, Lelliot CJ, Campbell M, Peddinti G, Martinez-Uña M, Ingvorsen C, Dias AR, Relat J, Mora S, Hyötyläinen T, Zorzano A, Orešič M, Bjursell M, Bohlooly-Y M, Lindén D, Vidal-Puig A. Allostatic hypermetabolic response in PGC1α/β heterozygote mouse despite mitochondrial defects. FASEB J. 2021 Sep;35(9):e21752. doi: 10.1096/fj.202100262RR. PMID:34369602
- Rodriguez-Cuenca S, Vidal-Puig A. Insulin and the last gasp of failing adipocytes. Nat Metab. 2021 Nov;3(11):1443-1444. doi: 10.1038/s42255-021-00492-7. PMID:34732886
- Romero-Picó A, Sanchez-Rebordelo E, Imbernon M, González-Touceda D, Folgueira C, Senra A, Fernø J, Blouet C, Cabrera R, van Gestel M, Adan RA, López M, Maldonado R, Nogueiras R, Diéguez C. Melanin-Concentrating Hormone acts through hypothalamic kappa opioid system and p70S6K to stimulate acute food intake. Neuropharmacology. 2018 Mar 1;130:62-70. doi: 10.1016/j.neuropharm.2017.11.040. PMID:29191753
- Rowe ER, Mimmack ML, Barbosa AD, Haider A, Isaac I, Ouberai MM, Thiam AR, Patel S, Saudek V, Siniossoglou S, Savage DB. Correction: Conserved amphipathic helices mediate lipid droplet targeting of perilipins 1-3. J Biol Chem. 2021 Dec 20;298(1):101490. doi: 10.1016/j.jbc.2021.101490. PMID:34942404 PMCID:PMC8695350
- Ruth KS, Day FR, Hussain J, Martínez-Marchal A, Aiken CE, Azad A, Thompson DJ, Knoblochova L, Abe H, Tarry-Adkins JL, Gonzalez JM, Fontanillas P, Claringbould A, Bakker OB, Sulem P, Walters RG, Terao C, Turon S, Horikoshi M, Lin K, Onland-Moret NC, Sankar A, Hertz EPT, Timshel PN, Shukla V, Borup R, Olsen KW, Aguilera P, Ferrer-Roda M, Huang Y, Stankovic S, Timmers PRHJ, Ahearn TU, Alizadeh BZ, Naderi E, Andrulis IL, Arnold AM, Aronson KJ, Augustinsson A, Bandinelli S, Barbieri CM, Beaumont RN, Becher H, Beckmann MW, Benonisdottir S, Bergmann S, Bochud M, Boerwinkle E, Bojesen SE, Bolla MK, Boomsma DI, Bowker N, Brody JA, Broer L, Buring JE, Campbell A, Campbell H, Castelao JE, Catamo E, Chanock SJ, Chenevix-Trench G, Ciullo M, Corre T, Couch FJ, Cox A, Crisponi L, Cross SS, Cucca F, Czene K, Smith GD, de Geus EJCN, de Mutsert R, De Vivo I, Demerath EW, Dennis J, Dunning AM, Dwek M, Eriksson M, Esko T, Fasching PA, Faul JD, Ferrucci L, Franceschini N, Frayling TM, Gago-Dominguez M, Mezzavilla M, García-Closas M, Gieger C, Giles GG, Grallert H, Gudbjartsson DF, Gudnason V, Guénel P, Haiman CA, Håkansson N, Hall P, Hayward C, He C, He W, Heiss G, Høffding MK, Hopper JL, Hottenga JJ, Hu F, Hunter D, Ikram MA, Jackson RD, Joaquim MDR, John EM, Joshi PK, Karasik D, Kardia SLR, Kartsonaki C, Karlsson R, Kitahara CM, Kolcic I, Kooperberg C, Kraft P, Kurian AW, Kutalik Z, La Bianca M, LaChance G, Langenberg C, Launer LJ, Laven JSE, Lawlor DA, Le Marchand L, Li J, Lindblom A, Lindstrom S, Lindstrom T, Linet M, Liu Y, Liu S, Luan J, Mägi R, Magnusson PKE, Mangino M, Mannermaa A, Marco B, Marten J, Martin NG, Mbarek H, McKnight B, Medland SE, Meisinger C, Meitinger T, Menni C, Metspalu A, Milani L, Milne RL, Montgomery GW, Mook-Kanamori DO, Mulas A, Mulligan AM, Murray A, Nalls MA, Newman A, Noordam R, Nutile T, Nyholt DR, Olshan AF, Olsson H, Painter JN, Patel AV, Pedersen NL, Perjakova N, Peters A, Peters U, Pharoah PDP, Polasek O, Porcu E, Psaty BM, Rahman I, Rennert G, Rennert HS, Ridker PM, Ring SM, Robino A, Rose LM, Rosendaal FR, Rossouw J, Rudan I, Rueedi R, Ruggiero D, Sala CF, Saloustros E, Sandler DP, Sanna S, Sawyer EJ, Sarnowski C, Schlessinger D, Schmidt MK, Schoemaker MJ, Schraut KE, Scott C, Shekari S, Shrikhande A, Smith AV, Smith BH, Smith JA, Sorice R, Southey MC, Spector TD, Spinelli JJ, Stampfer M, Stöckl D, van Meurs JBJ, Strauch K, Styrkarsdottir U, Swerdlow AJ, Tanaka T, Teras LR, Teumer A, Þorsteinsdottir U, Timpson NJ, Toniolo D, Traglia M, Troester MA, Truong T, Tyrrell J, Uitterlinden AG, Ulivi S, Vachon CM, Vitart V, Völker U, Vollenweider P, Völzke H, Wang Q, Wareham NJ, Weinberg CR, Weir DR, Wilcox AN, van Dijk KW, Willemsen G, Wilson JF, Wolffenbuttel BHR, Wolk A, Wood AR, Zhao W, Zygmunt M; Biobank-based Integrative Omics Study (BIOS) Consortium; eQTLGen Consortium; Biobank Japan Project; China Kadoorie Biobank Collaborative Group; kConFab Investigators; LifeLines Cohort Study; InterAct consortium; 23andMe Research Team, Chen Z, Li L, Franke L, Burgess S, Deelen P, Pers TH, Grøndahl ML, Andersen CY, Pujol A, Lopez-Contreras AJ, Daniel JA, Stefansson K, Chang-Claude J, van der Schouw YT, Lunetta KL, Chasman DI, Easton DF, Visser JA, Ozanne SE, Namekawa SH, Solc P, Murabito JM, Ong KK, Hoffmann ER, Murray A, Roig I, Perry JRB. Genetic insights into biological mechanisms governing human ovarian ageing. Nature. 2021 Aug;596(7872):393-397. doi: 10.1038/s41586-021-03779-7. PMID:34349265
- Sam AH, Reid MD, Thakerar V, Gurnell M, Westacott R, Yeates P, Reed MWR, Brown CA. The influence of candidates’ physical attributes on assessors’ ratings in clinical practice. Med Teach. 2021 Feb 11:1-6. doi: 10.1080/0142159X.2021.1877268. PMID:33569973
- Sam AH, Wilson R, Westacott R, Gurnell M, Melville C, Brown CA. Thinking differently – Students’ cognitive processes when answering two different formats of written question. Med Teach. 2021 Jun 14:1-8. doi: 10.1080/0142159X.2021.1935831. PMID:34126840
- Samms RJ, Sloop KW, Gribble FM, Reimann F, Adriaenssens AE. GIPR Function in the Central Nervous System: Implications and Novel Perspectives for GIP-Based Therapies in Treating Metabolic Disorders. Diabetes. 2021 Jun 27:dbi210002. doi: 10.2337/dbi21-0002. PMID:34176786
- Sanchez-Delgado G, Martinez-Tellez B, Acosta FM, Virtue S, Vidal-Puig A, Gil A, Llamas-Elvira JM, Ruiz JR. Brown Adipose Tissue Volume and Fat Content are Positively Associated with Whole-Body Adiposity in Young Men, Not in Women. Diabetes. 2021 Apr 15:db210011. doi: 10.2337/db21-0011. PMID:33858825
- Sandovici I, Georgopoulou A, Pérez-García V, Hufnagel A, López-Tello J, Lam BYH, Schiefer SN, Gaudreau C, Santos F, Hoelle K, Yeo GSH, Burling K, Reiterer M, Fowden AL, Burton GJ, Branco CM, Sferruzzi-Perri AN, Constância M. The imprinted Igf2-Igf2r axis is critical for matching placental microvasculature expansion to fetal growth. Dev Cell. 2022 Jan 10;57(1):63-79.e8. doi: 10.1016/j.devcel.2021.12.005. PMID:34963058 PMCID:PMC8751640
- Sandovici I, Hammerle CM, Virtue S, Vivas-Garcia Y, Izquierdo-Lahuerta A, Ozanne SE, Vidal-Puig A, Medina-Gómez G & Constância M. Autocrine IGF2 programmes β-cell plasticity under conditions of increased metabolic demand. Scientific Reports. 2021 Apr 8;11(1):7717. doi: 10.1038/s41598-021-87292-x. PMID:33833312 PMCID:PMC8032793
- Saucisse N, Mazier W, Simon V, Binder E, Catania C, Bellocchio L, Romanov RA, Léon S, Matias I, Zizzari P, Quarta C, Cannich A, Meece K, Gonzales D, Clark S, Becker JM, Yeo GSH, Fioramonti X, Merkle FT, Wardlaw SL, Harkany T, Massa F, Marsicano G, Cota D. Functional heterogeneity of POMC neurons relies on mTORC1 signaling. Cell Rep. 2021 Oct 12;37(2):109800. doi: 10.1016/j.celrep.2021.109800. PMID:34644574
- Schoenmakers E, Chatterjee K. Human Genetic Disorders Resulting in Systemic Selenoprotein Deficiency. Int. J. Mol. Sci. (2021) 22: 12927. PMID:34884733 PMCID:PMC8658020
- Schoonejans JM, Blackmore HL, Ashmore TJ, Aiken CE, Fernandez-Twinn DS, Ozanne SE. Maternal Metformin Intervention during Obese Glucose-Intolerant Pregnancy Affects Adiposity in Young Adult Mouse Offspring in a Sex-Specific Manner. Int J Mol Sci. 2021 Jul 28;22(15):8104. doi: 10.3390/ijms22158104. PMID:34360870 PMCID:PMC8347264
- Schoonejans JM, Ozanne SE. Developmental programming by maternal obesity: Lessons from animal models. Diabet Med. 2021 Sep 23;e14694. doi: 10.1111/dme.14694. PMID:34553414
- Seelig E, Henning E, Keogh JM, Gillett D, Shin E, Buscombe J, van der Klaauw AA, Farooqi IS. Obesity due to melanocortin 4 receptor (MC4R) deficiency is associated with delayed gastric emptying. Clin Endocrinol (Oxf). 2021 Oct 25. doi: 10.1111/cen.14615. PMID:34694010
- Senanayake R, Gillett D, MacFarlane J, Van de Meulen M, Powlson A, Koulouri O, Casey R, Bashari W, Gurnell M. New types of localization methods for adrenocorticotropic hormone-dependent Cushing’s syndrome. Best Pract Res Clin Endocrinol Metab. 2021 Jan;35(1):101513. PMID:34045044
- Spiroski AM, Niu Y, Nicholas LM, Austin-Williams S, Camm EJ, Sutherland MR, Ashmore TJ, Skeffington KL, Logan A, Ozanne SE, Murphy MP, Giussani DA. Mitochondria antioxidant protection against cardiovascular dysfunction programmed by early-onset gestational hypoxia. FASEB J. 2021 May;35(5):e21446. doi: 10.1096/fj.202002705R. PMID:33788974
- Stern E, Schoenmakers N, Nicholas AK, Kassif E, Hamiel OP, Yeshayahu Y. A Novel mutation in the Thyroglobulin Gene resulting in Neonatal Goiter and Congenital Hypothyroidism in an Eritrean infant. J Clin Res Pediatr Endocrinol. 2021 Apr 9. doi: 10.4274/jcrpe.galenos.2021.2020.0278. PMID:33832185
- Tarry-Adkins JL, Grant ID, Ozanne SE, Reynolds RM, Aiken CE. Efficacy and Side Effect Profile of Different Formulations of Metformin: A Systematic Review and Meta-Analysis. Diabetes Ther. 2021 Jun 2. doi: 10.1007/s13300-021-01058-2. PMID:34075573
- Tarry-Adkins JL, Ozanne SE, Aiken CE. Impact of metformin treatment during pregnancy on maternal outcomes: a systematic review/meta-analysis. Sci Rep. 2021 Apr 29;11(1):9240. doi: 10.1038/s41598-021-88650-5. PMID:33927270 PMCID:PMC8085032
- Tilson SG, Morell CM, Lenaerts AS, Park SB, Hu Z, Jenkins B, Koulman A, Liang TJ, Vallier L. Modelling PNPLA3-Associated Non-Alcoholic Fatty Liver Disease Using Human Induced Pluripotent Stem Cells. Hepatology. 2021 Jul 20. doi: 10.1002/hep.32063. PMID:34288010
- Torok ME, Underwood BR, Toshner M, Waddington C, Sidhom E, Sharrocks K, Bousfield R, Summers C, Saunders C, McIntyre Z, Morris H, Piper J, Calderon G, Dennis S, Assari T, Marguerie de Rotrou A, Shaw A, Bradley J, O’Brien J, Rintoul RC, Smith I, Bullmore E, Chatterjee K and on behalf of the Cambridge COVID vaccine trial team. Challenges and opportunities for conducting a vaccine trial during the COVID-19 pandemic in the United Kingdom. Clinical Trials 2021. https://doi.org/10.1177/17407745211024764. PMID:34154428
- Tritos NA, Fazeli PK, McCormack A, Mallea-Gil SM, Pineyro MM, Christ-Crain M, Frara S, Labadzhyan A, Ioachimescu AG, Shimon I, Takahashi Y, Gurnell M, Fleseriu M; “Pituitary Society Delphi Collaborative Group”. Pituitary Society Delphi Survey: An international perspective on endocrine management of patients undergoing transsphenoidal surgery for pituitary adenomas. Pituitary. 2021 Jul 20:1-10. doi: 10.1007/s11102-021-01170-3. PMID:34283370 PMCID:PMC8294287
- Tundidor D, Meek CL, Yamamoto J, Martínez-Bru C, Gich I, Feig DS, Murphy HR, Corcoy R; CONCEPTT Collaborative Group. Continuous Glucose Monitoring Time-in-Range and HbA 1c Targets in Pregnant Women with Type 1 Diabetes. Diabetes Technol Ther. 2021 May 25. doi: 10.1089/dia.2021.0073. PMID:33945304
- van Beijsterveldt IALP, Snowden SG, Myers PN, de Fluiter KS, van de Heijning B, Brix S, Ong KK, Dunger DB, Hokken-Koelega ACS, Koulman A. Metabolomics in early life and the association with body composition at age 2 years. Pediatr Obes. 2021 Oct 13;e12859. doi: 10.1111/ijpo.12859. PMID:34644810
- van Geest FS, Groeneweg S, van den Akker ELT, Bacos I, Barca D, van den Berg SAA, Bertini E, Brunner D, Brunetti-Pierri N, Cappa M, Cappuccio G, Chatterjee K, Chesover AD, Christian P, Coutant R, Craiu D, Crock P, Dewey C, Dica A, Dimitri P, Dubey R, Enderli A, Fairchild J, Gallichan J, Garibaldi LR, George B, Hackenberg A, Heinrich B, Huynh T, Kłosowska A, Lawson-Yuen A, Linder-Lucht M, Lyons G, Lora FM, Moran C, Müller KE, Paone L, Paul PG, Polak M, Porta F, Reinauer C, de Rijke YB, Seckold R, Menevşe TS, Simm P, Simon A, Spada M, Stoupa A, Szeifert L, Tonduti D, van Toor H, Turan S, Vanderniet J, de Waart M, van der Wal R, van der Walt A, van Wermeskerken AM, Wierzba J, Zibordi F, Zung A, Peeters RP, Visser WE. Long-term efficacy of T3 analogue Triac in children and adults with MCT8 deficiency: a real-life retrospective cohort study. J Clin Endocrinol Metab. 2021 Oct 22:dgab750. doi: 10.1210/clinem/dgab750. PMID:34679181
- Vickneson K, Blackburn J, Gallagher JR, Evans ML, de Galan BE, Pedersen-Bjergaard U, Thorens B, McNeilly AD, McCrimmon RJ. Cold-induced dishabituation in rodents exposed to recurrent hypoglycaemia. Diabetologia. 2021 Mar 17. doi: 10.1007/s00125-021-05425-3. PMID:33730186
- Virtue S, Lelliott CJ, Vidal-Puig A.What is the most appropriate covariate in ANCOVA when analysing metabolic rate? Nat Metab. 2021 Dec;3(12):1585. doi: 10.1038/s42255-021-00505-5. PMID:34903886
- Virtue S, Vidal-Puig A. GTTs and ITTs in mice: simple tests, complex answers. Nat Metab. 2021 Jun 11. doi: 10.1038/s42255-021-00414-7. PMID:34117483
- Wade KH, Lam BYH, Melvin A, Pan W, Corbin LJ, Hughes DA, Rainbow K, Chen JH, Duckett D, Liu X, Mokrosinski J, Morseburg A, Neaves S, Williamson A, Zhang C, Farooqi S, Yeo GSH, Timpson NJ, O’Rahilly S. Loss of function mutations in the melanocortin 4 receptor in a UK birth cohort. Nat Med. 2021 May 27. doi: 10.1038/s41591-021-01349-y. PMID:34045736
- Ward DL, Schroeder L, Pomeroy E, Roy JE, Buck LT, Stock JT, Martin-Gronert M, Ozanne SE, Silcox MT, Viola TB. Early life malnutrition and fluctuating asymmetry in the rat bony labyrinth. Anat Rec (Hoboken). 2021 Feb 15. doi: 10.1002/ar.24601. PMID:33586866
- Ware J, Hovorka R. Recent advances in closed-loop insulin delivery. Metabolism. 2022 Feb;127:154953. doi: 10.1016/j.metabol.2021.154953. PMID:34890648
- Westwater ML, Mancini F, Gorka AX, Shapleske J, Serfontein J, Grillon C, Ernst M, Ziauddeen H, Fletcher PC. Prefrontal responses during proactive and reactive inhibition are differentially impacted by stress in anorexia and bulimia nervosa. J Neurosci. 2021 Apr 12:JN-RM-2853-20. doi: 10.1523/JNEUROSCI.2853-20.2021. PMID:33846229
- Wever MCM, van Meer F, Charbonnier L, Crabtree DR, Buosi W, Giannopoulou A, Androutsos O, Johnstone AM, Manios Y, Meek CL, Holst JJ, Smeets PAM; Full4Health consortium. Associations between ghrelin and leptin and neural food cue reactivity in a fasted and sated state. Neuroimage. 2021 Oct 15;240:118374. doi: 10.1016/j.neuroimage.2021.118374. PMID:34245869
- Woodward OR, Gribble FM, Reimann F, Lewis JE. Gut peptide regulation of food intake – evidence for the modulation of hedonic feeding. J Physiol. 2021 Jun 21. doi: 10.1113/JP280581. PMID:34152020
- Wylie TA, Shah C, Burgess L, Robertson E, Dupont D, Swindell R, Hovorka R, Murphy HR, Heller SR. Optimising the use of technology to support people with diabetes: research recommendations from Diabetes UK’s 2019 diabetes and technology workshop. Diabet Med. 2021 Jul 16:e14647. doi: 10.1111/dme.14647. PMID:34270822
- Yang M, Darwish T, Larraufie P, Rimmington D, Cimino I, Goldspink DA, Jenkins B, Koulman A, Brighton CA, Ma M, Lam BYH, Coll AP, O’Rahilly S, Reimann F, Gribble FM. Inhibition of mitochondrial function by metformin increases glucose uptake, glycolysis and GDF-15 release from intestinal cells. Sci Rep. 2021 Jan 28;11(1):2529. doi: 10.1038/s41598-021-81349-7. PMID:33510216 PMCID:PMC7843649
- Yang M, Reimann F, Gribble FM. Chemosensing in enteroendocrine cells: mechanisms and therapeutic opportunities. Curr Opin Endocrinol Diabetes Obes. 2021 Apr 1;28(2):222-231. doi: 10.1097/MED.0000000000000614. PMID:33449572
- Yeo GSH, Moro Chao DH, Siegert AM, Koerperich ZM, Ericson MD, Simonds SE, Larson CM, Luquet S, Clarke I, Sharma S, Clément K, Cowley MA, Haskell-Luevano C, Van Der Ploeg L, Adan RAH. The melanocortin pathway and energy homeostasis: From discovery to obesity therapy. Mol Metab. 2021 Mar 5:101206. doi: 10.1016/j.molmet.2021.101206. PMID:33684608
- Yeo GSH, O’Rahilly S. Finding genes that control body weight. Science. 2021 Jul 2;373(6550):30-31. doi: 10.1126/science.abh3556. PMID:34210869
- Yu X, Newland SA, Zhao TX, Lu Y, Sage AS, Sun Y, Sriranjan RS, Ma MKL, Lam BYH, Nus M, Harrison JE, Bond SJ, Cheng X, Silvestre JS, Rudd JHF, Cheriyan J, Mallat Z. Innate Lymphoid Cells Promote Recovery of Ventricular Function After Myocardial Infarction. J Am Coll Cardiol. 2021 Sep 14;78(11):1127-1142. doi: 10.1016/j.jacc.2021.07.018. PMID:34503682 PMCID:PMC8434674
- Zhou J, Azizan EAB, Cabrera CP, Fernandes-Rosa FL, Boulkroun S, Argentesi G, Cottrell E, Amar L, Wu X, O’Toole S, Goodchild E, Marker A, Senanayake R, Garg S, Åkerström T, Backman S, Jordan S, Polubothu S, Berney DM, Gluck A, Lines KE, Thakker RV, Tuthill A, Joyce C, Kaski JP, Karet Frankl FE, Metherell LA, Teo AED, Gurnell M, Parvanta L, Drake WM, Wozniak E, Klinzing D, Kuan JL, Tiang Z, Gomez Sanchez CE, Hellman P, Foo RSY, Mein CA, Kinsler VA, Björklund P, Storr HL, Zennaro MC, Brown MJ. Somatic mutations of GNA11 and GNAQ in CTNNB1-mutant aldosterone-producing adenomas presenting in puberty, pregnancy or menopause. Nat Genet. 2021 Sep;53(9):1360-1372. doi: 10.1038/s41588-021-00906-y. PMID:34385710
2020
- Alligier M, Barrès R, Blaak EE, Boirie Y, Bouwman J, Brunault P, Campbell K, Clément K, Farooqi IS, Farpour-Lambert NJ, Frühbeck G, Goossens GH, Hager J, Halford JCG, Hauner H, Jacobi D, Julia C, Langin D, Natali A, Neovius M, Oppert JM, Pagotto U, Palmeira AL, Roche H, Rydén M, Scheen AJ, Simon C, Sorensen TIA,Tappy L, Yki-Järvinen H, Ziegler O, Laville M. OBEDIS Core Variables roject: European Expert Guidelines on a Minimal Core Set of Variables to Include in Randomized, Controlled Clinical Trials of Obesity Interventions. Obes Facts. 2020 Jan 13:1-28. Epub ahead of print. PubMed PMID: 31945762. PMCID: PMC7098277.
- Anstee QM, Darlay R, Cockell S, Meroni M, Govaere O, Tiniakos D, Burt AD, Bedossa P, Palmer J, Liu YL, Aithal GP, Allison M, Yki-Järvinen H, Vacca M, Dufour JF, Invernizzi P, Prati D, Ekstedt M, Kechagias S, Francque S, Petta S, Bugianesi E, Clement K, Ratziu V, Schattenberg JM, Valenti L, Day CP, Cordell HJ, Daly AK; EPoS Consortium Investigators. Genome-wide Association Study of Non-Alcoholic Fatty Liver and Steatohepatitis in a Histologically-Characterised Cohort. Journal of Hepatology. 2020 Apr 13:S0168-8278(20)30213-0. PMID: 32298765.
- Araiz C, Yan A, Bettedi L, Samuelson I, Virtue S, McGavigan AK, Dani C, Vidal-Puig A, Foukas LC. Publisher Correction: Enhanced β-Adrenergic Signalling Underlies an Age-Dependent Beneficial Metabolic Effect of PI3K p110α Inactivation in Adipose Tissue. Nat Commun. 2020 Feb 21;11(1):1078. PMID: 32081871.
- Ast J, Arvaniti A, Fine NHF, Nasteska D, Ashford FB, Stamataki Z, Koszegi Z, Bacon A, Jones BJ, Lucey MA, Sasaki S, Brierley DI, Hastoy B, Tomas A, D’Agostino G, Reimann F, Lynn FC, Reissaus CA, Linnemann AK, D’Este E, Calebiro D, Trapp S, Johnsson K, Podewin T, Broichha- gen J, Hodson DJ. Author Correction: Super-resolution microscopy compatible fluorescent probes reveal endogenous glucagon-like peptide-1 receptor distribution and dynamics. Nat Commun. 2020 Oct 9;11(1):5160. PMID: 33037231.
- Azzu V, Vacca M, Virtue S, Allison M, Vidal-Puig A. Adipose tissue-liver cross talk in the control of whole-body metabolism: implications in non-alcoholic fatty liver disease. Gastroenterology. 2020 Feb 12. pii: S0016-5085(20)30224-9. Epub ahead of print. PMID: 32061598.
- Baig S, Shabeer M, Parvaresh Rizi E, Agarwal M, Lee MH, Ooi DSQ, Chia C, Aung N, Ng G, Teo Y, Chhay V, Magkos F, Vidal-Puig A, Seet RCS, Toh SA. Heredity of type 2 diabetes confers increased susceptibility to oxidative stress and inflammation. BMJ Open Diabetes Res Care. 2020 Jan;8(1). PMID: 32049633. PMCID: PMC7039582.
- Banholzer N, Herzig D, Piazza C, Álvarez-Martínez M, Nakas CT, Kosinski C, Feuerriegel S, Hovorka R, Bally L. Effect of nutrition on postprandial glucose control in hospitalized patients with type 2 diabetes receiving fully automated closed-loop insulin therapy. Diabetes Obes Metab. 2020 Sep 4. PMID: 32885596.
- Bashari WA, Senanayake R, Koulouri O, Gillett D, MacFarlane J, Powlson AS, FernandezPombo A, Bano G, Martin AJ, Scoffings D, Cheow H, Mendichovszky I, Tysome J, Donnelly N, Santarius T, Kolias A, Mannion R, Gurnell M. PET-guided Repeat Transsphenoidal Surgery for Previously Deemed Unresectable Lateral Disease in Acromegaly. Neurosurgical Focus. 2020 Jun;48(6):E8. PMID: 32480379.
- Bernstein RM, O’Connor GK, Vance EA, Affara N, Drammeh S, Dunger DB, Faal A, Ong KK, Sosseh F, Prentice AM, Moore SE. Timing of the Infancy-Childhood Growth Transition in Rural Gambia. Frontiers of Endocrinology (Lausanne). 2020 Mar 24;11:142. PMID: 32265838 PMCID: PMC7105771.
- Blackwell AKM, De-Loyde K, Brocklebank LA, Maynard OM, Marteau TM, Hollands GJ, Fletcher PC, Attwood AS, Morris RW, Munafò MR. Tobacco and electronic cigarette cues for smoking and vaping: an online experimental study. BMC Res Notes. 2020 Jan 15;13(1):32. PubMed PMID:31941548; PubMed Central PMCID: PMC6964108.
- Blackwell AKM, De-Loyde K, Hollands GJ, Morris RW, Brocklebank LA, Maynard OM, Fletcher PC, Marteau TM, Munafò MR. The Impact on Selection of Non-Alcoholic vs Alcoholic Drink Availability: An Online Experiment. BMC Public Health. 2020 May 6;20(1):526. PMID: 32370760 PMCID: PMC7201696.
- Blastland M, Freeman ALJ, van der Linden S, Marteau TM, Spiegelhalter D. Five rules for evidence communication. Nature. 2020 Nov;587(7834):362-364. doi: 10.1038/d41586-020-03189-1. PMID: 33208954.
- Boughton C, Allen JM, Tauschmann M, Hartnell S, Wilinska ME, Musolino G, Acerini CL, Dunger PD, Campbell F, Ghatak A, Randell T, Besser R, Trevelyan N, Elleri D, Northam E, Hood K, Scott E, Lawton J, Roze S, Sibayan J, Kollman C, Cohen N, Todd J, Hovorka R; CLOuD Consortium. Assessing the effect of closed-loop insulin delivery from onset of type 1 diabetes in youth on residual beta-cell function compared to standard insulin therapy (CLOuD study): a randomised parallel study protocol. BMJ Open. 2020 Mar 12;10(3):e033500. PMID: 32169925; PMCID: PMC7069267.
- Boughton CK, Hartnell S, Allen JM, Fuchs J, Hovorka R. Training and Support for Hybrid Closed -Loop Therapy. J Diabetes Sci Technol. 2020 Sep 11;1932296820955168. PMID: 32914648.
- Boughton CK, Hovorka R. The artificial pancreas. Curr Opin Organ Transplant. 2020 Aug;25 (4):336-342. PMID: 32618719.
- Braukmann F, Jordan D, Jenkins B, Koulman A, Miska EA. SID-2 negatively regulates develop- ment likely independent of nutritional dsRNA uptake. RNA Biol. 2020 Oct 12;1-12. PMID: 33044912.
- Brierley GV, Webber H,2 Rasijeff E, Grocott S, Siddle K, Semple RK. Anti-Insulin Receptor Anti- bodies Improve Hyperglycemia in a Mouse Model of Human Insulin Receptoropathy. Diabetes 2020;69:1–9. PMID: 32816962.
- Burton NO, Riccio C, Dallaire A, Price J, Jenkins B, Koulman A, Miska EA. Cysteine Synthases CYSL-1 and CYSL-2 Mediate C. Elegans Heritable Adaptation to P. Vranovensis Infection. Nature Communications. 2020 Apr 8;11(1):1741. PMID: 32269224 PMCID: PMC7142082.
- Calderon G , McRae A, Rievaj J, Davis J, Zandvakili I, Linker-Nord S, Burton D, Roberts G, Reimann F, Gedulin B, Vella A, LaRusso NF, Camilleri M, Gribble FM, Acosta A. Ileo-Colonic Delivery of Conjugated Bile Acids Improves Glucose Homeostasis Via Colonic GLP-1-Producing Enteroendocrine Cells in Human Obesity and Diabetes. EbioMedicine Vol 55, May 2020:102759. PMID: 32344198, PMCID: PMC7186521.
- Campbell, J. R., Martchenko, A., Sweeney, M. E., Maalouf, M. F., Psichas, A., Gribble, F. M., Reimann, F., Brubaker PL. Essential role of syntaxin-binding protein-1 in the regulation of glucagon-like peptide-1 secretion. Endocrinology. Volume 161, Issue 5, May 2020. PMID: 32141504.
- Campi I, Covelli D, Moran C, Fugazzola L, Cacciatore C, Orlandi F, Gallone G, Chatterjee K, Beck-Peccoz P, Persani L. The Differential Diagnosis of Discrepant Thyroid Function Tests: Insistent Pitfalls and Updated Flow-Chart Based on a Long-Standing Experience. Front Endocrinol (Lausanne) 2020 Jul 7;11:432. PMID: 32733382. PMC7358450.
- Chae H, Augustin R, Gatineau E, Mayoux E, Bensellam M, Antoine N, Khattab F, Lai BK, Brusa D, Stierstorfer B, Klein H, Singh B, Ruiz L, Pieper M, Mark M, Herrera PL, Gribble FM, Reimann F, Wojtusciszyn A, Broca C, Rita N, Piemonti L, Gilon P. SGLT2 is not expressed in pancreatic α – and β-cells, and its inhibition does not directly affect glucagon and insulin secretion in rodents and humans. Mol Metab. 2020 Sep 5;42:101071. PMID: 32896668.
- Chalmers J, Tung YCL, Liu CH, O’Kane CJ, O’Rahilly S, Yeo GSH. A multi-component screen for feeding behaviour and nutritional status in Drosophila to interrogate mammalian appetite-related genes. Mol Metab
. 2020 Nov 23;101127. doi: 10.1016/j.molmet.2020.101127. PMID: 33242659 PMCID: PMC7753202 - Cheng W, Gonzalez I, Pan W, Tsang A H, Adams J, Nkoda E, Gordian D, Khoury B, Roelofs K, Evers S, MacKinnon A, Wu S, Frikke-Schmidt H, Flak J N, Trevaskis J L, Rhodes C J, Fukada S, Seeley R J, Sandoval D A, Olson D P, Blouet C, and Myers, Jr M G. Calcitonin Receptor Neurons in the Mouse Nucleus Tractus Solitarius Control Energy Balance via the non-Aversive Suppression of Feeding. Cell Metab. 2020 Feb 4;31(2):301-312.e5. PubMed PMID: 31955990.
- Chiesa ST, Marcovecchio ML, Benitez-Aguirre P, Cameron FJ, Craig ME, Couper JJ, Davis EA, Dalton RN, Daneman D, Donaghue KC, Jones TW, Mahmud FH, Marshall SM, Neil HAW, Dunger DB, Deanfield JE; Adolescent Type 1 Diabetes Cardio-Renal Intervention Trial (AdDIT) Study Group. Vascular Effects of ACE (Angiotensin-Converting Enzyme) Inhibitors and Statins in Adolescents With Type 1 Diabetes. Hypertension. 2020 Dec;76(6):1734-1743. doi: 10.1161/HYPERTENSIONAHA.120.15721. PMID: 33100044.
- Clarke N, Pechey E, Mantzari E, Blackwell AKM, De-Loyde K, Morris RW, Munafò MR, Marteau TM, Hollands GJ. Impact of Health Warning Labels Communicating the Risk of Cancer on Alcohol Selection: An Online Experimental Study. Addiction. 2020 Apr 8. PMID: 32267588.
- Clément K, van den Akker E, Argente J, Bahm A, Chung WK, Connors H, De Waele K, Farooqi IS, Gonneau-Lejeune J, Gordon G, Kohlsdorf K, Poitou C, Puder L, Swain J, Stewart M, Yuan G, Wabitsch M, Kühnen P; Setmelanotide POMC and LEPR Phase 3 Trial Investigators. Efficacy and safety of setmelanotide, an MC4R agonist, in individuals with severe obesity due to LEPR or POMC deficiency: single-arm, open-label, multicentre, phase 3 trials. Lancet Diabetes Endocrinol. 2020 Dec;8(12):960-970. doi: 10.1016/S2213-8587(20)30364-8. PMID: 33137293.
- Coll AP, Chen M, Taskar P, Rimmington D, Patel S, Tadross JA, Cimino I, Yang M, Welsh P, Virtue S, Goldspink DA, Miedzybrodzka EL, Konopka AR, Esponda RR, Huang JT, Tung YCL, Rodriguez-Cuenca S, Tomaz RA, Harding HP, Melvin A, Yeo GSH, Preiss D, Vidal-Puig A, Vallier L, Nair KS, Wareham NJ, Ron D, Gribble FM, Reimann F, Sattar N, Savage DB, Allan BB, O’Rahilly S. Publisher Correction: GDF15 mediates the effects of metformin on body weight and energy balance. Nature. 2020 Feb;578(7796):E24. PMID: 32051582.
- Colombo M, McGurnaghan SJ, Blackbourn LAK, Dalton RN, Dunger D, Bell S, Petrie JR, Green F, MacRury S, McKnight JA, Chalmers J, Collier A, McKeigue PM, Colhoun HM; Scottish Diabetes Research Network (SDRN) Type 1 Bioresource Investigators. Comparison of Serum and Urinary Biomarker Panels With Albumin/Creatinine Ratio in the Prediction of Renal Function Decline in Type 1 Diabetes. Diabetologia. 2020 Apr;63(4):788-798. PMID: 31915892 PMCID: PMC7054370.
- Crabtree DR, Buosi W, Fyfe CL, Horgan GW, Manios Y, Androutsos O, Giannopoulou A, Finlayson G, Beaulieu K, Meek CL, Holst JJ, Van Norren KV, Mercer JG, Johnstone AM. Appetite Control across the Lifecourse: The Acute Impact of Breakfast Drink Quantity and Protein Content. The Full4Health Project. Nutrients. 2020 Nov 30;12(12):3710. doi: 10.3390/nu12123710. PMID:33266325 PMCID:PMC7759987
- de Almeida-Faria J, Duque-Guimarães DE 1, Ong TP, Pantaleão LC, Carpenter AA, Loche E, Kusinski LC, Ashmore TJ, Antrobus R, Bushell M, Fernandez-Twinn DS, Ozanne SE. Maternal obesity during pregnancy leads to adipose tissue ER stress in mice via miR-126-mediated reduction in Lunapark. Diabetologia.
- Dearden L, Buller S, Furigo IC, Fernandez-Twinn DS, Ozanne SE. Maternal obesity causes fetal hypothalamic insulin resistance and disrupts development of hypothalamic feeding pathways. Mol Metab. 2020 Sep 9;42:101079. PMID: 32919096 PMC7549144.
- de Barros Mucci D, Kusinski LC, Wilsmore P, Loche E, Pantaleão LC, Ashmore TJ, Blackmore HL, Fernandez-Twinn DS, Carmo MDGTD, Ozanne SE. Impact of maternal obesity on placental transcriptome and morphology associated with fetal growth restriction in mice. Int J Obes (Lond). 2020 Mar 13. PMID:32203108.
- Diederen KMJ, Fletcher PC. Dopamine, Prediction Error and Beyond. Neuroscientist. 2020 Apr 26:1073858420907591. PMID: 32338128.
- Fisher BG, Thankamony A, Mendiola J, Petry CJ, Frederiksen H, Andersson AM, Juul A, Ong KK, Dunger DB, Hughes IA, Acerini CL. Maternal Serum Concentrations of Bisphenol A and Propyl Paraben in Early Pregnancy Are Associated With Male Infant Genital Development. Human Reproduction. 2020 Apr 28;35(4):913-928. PMID: 32325494.
- Fleseriu M, Buchfelder M, Cetas JS, Fazeli PK, Mallea-Gil SM, Gurnell M, McCormack A, Pineyro MM, Syro LV, Tritos NA, Marcus HJ. Pituitary society guidance: pituitary disease management and patient care recommendations during the COVID-19 pandemic-an international perspective. Pituitary. 2020 Aug;23(4):327-337. PMID: 32556793. PMC7300368.
- Fuchs J, Hovorka R. Closed-loop control in insulin pumps for type-1 diabetes mellitus: safety and efficacy. Expert Rev Med Devices. 2020 Jul 3;1-14. PMID: 32569476.
- Fuchs J, Hovorka R. COVID-19 and Diabetes: Could Diabetes Technology Research Help Pave the Way for Remote Healthcare? Journal of Diabetes Science and Technology. 2020 May 30:1932296820929714. PMID: 32475169.
- Furse S, Fernandez-Twinn DS, Jenkins B, Meek CL, Williams HEL, Smith GCS, CharnockJones DS, Ozanne SE, Koulman A. A high-throughput platform for detailed lipidomic analysis of a range of mouse and human tissues. Anal Bioanal Chem. 2020 Mar 7. Epub ahead of print. PMID: 32144454.
- Furse S, Koulman A. Lipid extraction from dried blood spots and dried milk spots for untargeted high throughput lipidomics. Mol Omics. 2020 Sep 18. PMID: 32945330.
- Furse S, Watkins AJ, Koulman A. Extraction of Lipids from Liquid Biological Samples for HighThroughput Lipidomics. Molecules. 2020 Jul 13;25(14):E3192. PMID: 32668693.
- Galindo RJ, Umpierrez GE, Rushakoff RJ, Basu A, Lohnes S, Nichols JH, Spanakis EK, Espino- za J, Palermo NE, Awadjie DG, Bak L, Buckingham B, Cook CB, Freckmann G, Heinemann L, Hovorka R, Mathioudakis N, Newman T, O’Neal DN, Rickert M, Sacks DB, Seley JJ, Wallia A, Shang T, Zhang JY, Han J, Klonoff DC. Continuous Glucose Monitors and Automated Insulin Dosing Systems in the Hospital Consensus Guideline. J Diabetes Sci Technol. 2020 Sep 28;1932296820954163. PMID: 32985262.
- Georgescu T, Lyons D, Doslikova B, Garcia AP, Marston O, Burke LK, Chianese R, Lam BYH, Yeo GSH, Rochford JJ, Garfield AS, Heisler LK. Neurochemical Characterization of Brainstem Pro-Opiomelanocortin Cells. Endocrinology. 2020 Apr 1;161(4). PMID: 32166324.
- Gil A, Rueda R, Ozanne SE, van der Beek EM, van Loo-Bouwman C, Schoemaker M, Marinello V, Venema K, Stanton C, Schelkle B, Flourakis M, Edwards CA. Is there evidence for bacterial transfer via the placenta and any role in the colonization of the infant gut? – a systematic review. Crit Rev Microbiol. 2020 Aug 10;1-15. PMID: 32776793.
- Giustina A, Barkhoudarian G, Beckers A, Ben-Shlomo A, Biermasz N, Biller B, Boguszewski C, Bolanowski M, Bollerslev J, Bonert V, Bronstein MD, Buchfelder M, Casanueva F, Chanson P, Clemmons D, Fleseriu M, Formenti AM, Freda P, Gadelha M, Geer E, Gurnell M, Heaney AP, Ho KKY, Ioachimescu AG, Lamberts S, Laws E, Losa M, Maffei P, Mamelak A, Mercado M, Molitch M, Mortini P, Pereira AM, Petersenn S, Post K, Puig-Domingo M, Salvatori R, Samson SL, Shimon I, Strasburger C, Swearingen B, Trainer P, Vance ML, Wass J, Wierman ME, Yuen KCJ, Zatelli MC, Melmed S. Multidisciplinary management of acromegaly: A consensus. Rev Endocr Metab Disord. 2020 Dec;21(4):667-678. PMID: 32914330.
- Goh, K.J., Chen, J., Rocha, N. Semple, R.K. Human pluripotent stem cell-based models suggest preadipocyte senescence as a possible cause of metabolic complications of Werner and Bloom Syndromes. Scientific Reports. Vol 10, Article number: 7490 (2020). PMID: 32367056, PMC7198505.
- Goldspink DA, Lu VB, Miedzybrodzka EL, Smith CA, Foreman RE, Billing LJ, Kay RG, *Reimann F, *Gribble FM (2020) Labelling and characterization of human GLP-1 secreting Lcells in primary ileal organoid culture. Cell Reports 2020 Jun 30;31(13):107833. doi: 10.1016/j.celrep.2020.107833. PMID: 32610134
- Govaere O, Cockell S, Tiniakos D, Queen R, Younes R, Vacca M, Alexander L, Ravaioli F, Palmer J, Petta S, Boursier J, Rosso C, Johnson K, Wonders K, Day CP, Ekstedt M, Orešič M, Darlay R, Cordell HJ, Marra F, Vidal-Puig A, Bedossa P, Schattenberg JM, Clément K, Allison M, Bugianesi E, Ratziu V, Daly AK, Anstee QM. Transcriptomic profiling across the nonalcoholic fatty liver disease spectrum reveals gene signatures for steatohepatitis and fibrosis. Sci Transl Med. 2020 Dec 2;12(572):eaba4448. doi:10.1126/scitranslmed.aba4448. PMID: 33268509.
- Groeneweg S, van Geest FS, Abacı A, Alcantud A, Ambegaonkar GP, Armour CM, Bakhtiani P, Barca D, Bertini ES, van Beynum IM, Brunetti-Pierri N, Bugiani M, Cappa M, Cappuccio G, Castellotti B, Castiglioni C, Chatterjee K, de Coo IFM, Coutant R, Craiu D, Crock P, DeGoede C, Demir K, Dica A, Dimitri P, Dolcetta-Capuzzo A, Dremmen MHG, Dubey R, Enderli A, Fairchild J, Gallichan J, George B, Gevers EF, Hackenberg A, Halász Z, Heinrich B, Huynh T, Kłosowska A, van der Knaap MS, van der Knoop MM, Konrad D, Koolen DA, Krude H, Lawson-Yuen A, Lebl J, Linder-Lucht M, Lorea CF, Lourenço CM, Lunsing RJ, Lyons G, Malikova J, Mancilla EE, McGowan A, Mericq V, Lora FM, Moran C, Müller KE, Oliver-Petit I, Paone L, Paul PG, Polak M, Porta F, Poswar FO, Reinauer C, Rozenkova K, Menevse TS, Simm P, Simon A, Singh Y, Spada M, van der Spek J, Stals MAM, Stoupa A, Subramanian GM, Tonduti D, Turan S, den Uil CA, Vanderniet J, van der Walt A, Wémeau JL, Wierzba J, de Wit MY, Wolf NI, Wurm M, Zibordi F, Zung A, Zwaveling-Soonawala N, Visser WE. Disease characteristics of MCT8 deficiency: an international, retrospective, multicentre cohort study. Lancet Diabetes Endocrinol. 2020 Jul;8 (7):594-605. PMID: 32559475.
- Fang Z, Chen S, Manchanda Y, Bitsi S, Pickford P, David A, Shchepinova MM, Corrêa IR Jr, Hodson DJ, Broichhagen J, Tate EW, Reimann F, Salem V, Rutter GA, Tan T, Bloom SR, Tomas A, Jones B. Ligand-Specific Factors Influencing GLP-1 Receptor Post-Endocytic Trafficking and Degradation in Pancreatic Beta Cells. Int J Mol Sci. 2020 Nov 9;21(21):8404. doi: 10.3390/ijms21218404. PMID: 33182425 PMCID: PMC7664906
- Haarsma J, Fletcher PC, Griffin JD, Taverne HJ, Ziauddeen H, Spencer TJ, Miller C, Katthagen T, Goodyer I, Diederen KMJ, Murray GK. Correction: Precision weighting of cortical unsigned prediction error signals benefits learning, is mediated by dopamine, and is impaired in psycho- sis. Mol Psychiatry. 2020 Oct 14. PMID: 33057170.
- Hall Z, Chiarugi D, Charidemou E, Leslie J, Scott E, Pelligrinet L, Allison M, Mocciaro G, Anstee QM, Evan GI, Hoare M, Vidal-Puig A, Oakley F, Vacca M, Griffin JL. Lipid Remodelling in Hepatocyte Proliferation and Hepatocellular Carcinoma. Hepatology. 2020 May 27. PMID: 32460431.
- Hammerle CM, Sandovici I, Brierley GV, Smith NM, Zimmer WE, Zvetkova I, Prosser HM, Sekita Y, Lam BYH, Ma M, Cooper WN, Vidal-Puig A, Ozanne SE, Medina-Gómez G, Constância M. Mesenchyme-derived IGF2 is a major paracrine regulator of pancreatic growth and function. PLoS Genet. 2020 Oct 15;16(10):e1009069. PMID: 33057429.
- Herzig D, Studer D, Nakas CT, Kuenzli C, Stauffer TP, Hovorka R, Bally L. Effect of fully auto- mated closed-loop insulin delivery using faster aspart versus standard aspart on gluco- regulatory hormones in type 2 diabetes. Diabetes Obes Metab. 2020 Sep 9. PMID: 32902125.
- Holt MK, Cook DR, Brierley DI, Richards JE, Reimann F, Gourine AV, Marina N, Trapp S. PPG Neurons in the Nucleus of the Solitary Tract Modulate Heart Rate but Do Not Mediate GLP-1 Receptor Agonist-Induced Tachycardia in Mice. Molecular Metabolism. 2020 May 21:101024. PMID: 32446875.
- Hunter H, de Gracia Hahn D, Duret A, Ri Im Y, Cheah Q, Dong J, Fairey M, Hjalmarsson C, Li A, Kai Lim H, McKeown L, Mitrofan CG, Rao R, Utukuri M, Rowe IA, Mann JP. Weight loss, insulin resistance, and study design confound results in a meta-analysis of animal models of fatty liver. eLife 2020 Oct 16;9:e56573. doi: 10.7554/eLife.56573. PMID: 33063664 PMCID: PMC7647398.
- Jenkins B, Ronis M, Koulman A. LC-MS Lipidomics: Exploiting a Simple High-Throughput Method for the Comprehensive Extraction of Lipids in a Ruminant Fat Dose-Response Study. Metabolites. 2020 Jul 17;10(7):296. PMID: 32709069. PMC7407148.
- Jones KS, Parkington DA, Cox LJ, Koulman A. Erythrocyte transketolase activity coefficient (ETKAC) assay protocol for the assessment of thiamine status. Ann N Y Acad Sci. 2020 Dec 22. doi: 10.1111/nyas.14547. Epub ahead of print. PMID: 33354793.
- Joustra SD, Roelfsema F, van Trotsenburg ASP, Schneider HJ, Kosilek RP, Kroon HM, Logan JG, Butterfield NC, Zhou X, Toufaily C, Bak B, Turgeon MO, Brûlé E, Steyn FJ, Gurnell M, Koulouri O, Le Tissier P, Fontanaud P, Duncan Bassett JH, Williams GR, Oostdijk W, Wit JM, Pereira AM, Biermasz NR, Bernard DJ, Schoenmakers N. IGSF1 Deficiency Results in Human and Murine Somatotrope Neurosecretory Hyperfunction. J Clin Endocrinol Metab. 2020 Mar 1;105 (3). PubMed PMID: 31650157.
- Joustra SD, Roelfsema F, Paul van Trotsenburg AS, Schneider HJ, Kosilek RP, Kroon HM, Logan JG, Butterfield NC, Zhou X, Toufaily C, Bak B, Turgeon MO, Brûlé E, Steyn FJ, Gurnell M, Koulouri O, Le Tissier P, Fontanaud P, Bassett JHD, Williams GR, Oostdijk W, Wit JM, Pereira AM, Biermasz NR, Bernard DJ, Schoenmakers N. Response to Letter to the Editor: IGSF1 Deficiency Results in Human and Murine Somatotrope Neurosecretory Hyperfunction. J Clin Endocrinol Metab. 2020 Mar 24. PMID: 32211768
- Joustra SD, Roelfsema F, van Trotsenburg ASP, Schneider HJ, Kosilek RP, Kroon HM, Logan JG, Butterfield NC, Zhou X, Toufaily C, Bak B, Turgeon MO, Brûlé E, Steyn FJ, Gurnell M, Koulouri O, Le Tissier P, Fontanaud P, Bassett JHD, Williams GR, Oostdijk W, Wit JM, Pereira AM, Biermasz NR, Bernard DJ, Schoenmakers N. Response to Letter to the Editor: “IGSF1 Deficiency Results in Human and Murine Somatotrope Neurosecretory Hyperfunction”. Journal of Clinical Endocrinology and Metabolism. 2020 Jun 1;105(6):dgaa147. PMID: 32211768 PMCID: PMC7159029.
- Kanakis I, Alameddine M, Scalabrin M, van ‘t Hof RJ, Liloglou T, Ozanne SE, Goljanek-Whysall K, Vasilaki A. Low protein intake during reproduction compromises the recovery of lactationinduced bone loss in female mouse dams without affecting skeletal muscles. FASEB J. 2020 Jul 11. PMID: 32652768.
- Kay RG, Foreman RE, Roberts GP, Hardwick R, Reimann F, Gribble FM. Mass Spectrometric Characterisation of the Circulating Peptidome Following Oral Glucose Ingestion in Control and Gastrectomised Patients. Rapid Communications in Mass Spectrometry. 2020 Jun 3:e8849. PMID: 32492232.
- Khoo S, Lyons G, McGowan A, Gurnell M, Oddy S, Visser WE, van den Berg S, Halsall D, Taylor K, Chatterjee K, Moran C. Familial dysalbuminaemic hyperthyroxinemia interferes with current free thyroid hormone immunoassay methods. Eur J Endocrinol. 2020 Mar 1. PMID: 32213658.
- Khoo S, Lyons G, McGowan A, Gurnell M, Oddy S, Visser WE, van den Berg S, Halsall D, Taylor K, Chatterjee K, Moran C. Familial Dysalbuminaemic Hyperthyroxinaemia Interferes With Current Free Thyroid Hormone Immunoassay Methods. European Journal of Endocrinology. 2020 Jun;182(6):533-538. PMID: 32213658 PMCID: PMC7222281.
- Khoo S, Lyons G, Solomon A, Oddy S, Halsall D, Chatterjee K, Moran C. Familial dysalbuminemic hyperthyroxinemia confounding management of coexistent autoimmune thyroid disease. Endocrinol Diabetes Metab Case Rep. 2020 Feb 26;2020. PMID: 32101523.
- Kohnke S, Meek CL. Don’t seek, don’t find: the diagnostic challenge of Wernicke’s encephalopathy. Ann Clin Biochem. 2020 Jul13;PMID: 32551830
- Kolias A, Tysome J, Donnelly N, Sharma R, Gkrania-Klotsas E, Budohoski K, Karcheva S, Adapa R, Lawes I, Gurnell M, Hutchinson P, Bance M, Axon P, Santarius T, Mannion RJ. A Safe Approach to Surgery for Pituitary and Skull Base Lesions During the COVID-19 Pandemic. Acta Neurochirurgica (Wien). 2020 May 9:1-3. PMID: 32388681 PMCID: PMC7211050.
- Krycer JR, Elkington SD, Diaz-Vegas A, Cooke KC, Burchfield JG, Fisher-Wellman KH, Cooney GJ, Fazakerley DJ, James DE. Mitochondrial Oxidants, but Not Respiration, Are Sensitive to Glucose in Adipocytes. Journal of Biological Chemistry. 2020 Jan 3;295(1):99-110. PMID: 31744882 PMCID: PMC6952605.
- Kusinski LC, Murphy HR, Rolfe EL, Rennie KL, Griep LMO, Hughes D, Taylor R, Meek CL. Erratum: Dietary Intervention in Pregnant Women with Gestational Diabetes; Protocol for the DiGest Randomised Controlled Trial; Nutrients 2020, 12, 1165. Nutrients. 2020 Jun 17;12(6):1793. doi: 10.3390/nu12061793. PMID:32560576 PMCID:PMC7353399
- Kwok A, Zvetkova I, Virtue S, Luijten I, Huang-Doran I, Tomlinson P, Bulger DA, West J, Murfitt S, Griffin J, Alam R, Hart D, Knox R, Voshol P, Vidal-Puig A, Jensen J, O’Rahilly S, Semple RK. Truncation of Pik3r1 Causes Severe Insulin Resistance Uncoupled From Obesity and Dyslipidemia by Increased Energy Expenditure. Molecular Metabolism. 2020 May 18:101020. PMID: 32439336.
- Lachmann EH, Fox RA, Dennison RA, Usher-Smith JA, Meek CL, Aiken CE. Barriers to completing oral glucose tolerance testing in women at risk of gestational diabetes. Diabet Med. 2020 Sep;37(9):1482-1489. doi: 10.1111/dme.14292. PMID:32144795
- Langfield T, Pechey R, Pilling MA, Marteau TM. Glassware design and drinking behaviours: a review of impact and mechanisms using a new typology of drinking behaviours. Health Psychol Rev. 2020 Nov 18;1-23. doi: 10.1080/17437199.2020.1842230. PMID: 33140699.
- Lawler K, Huang-Doran I, Sonoyama T, Collet TH, Keogh JM, Henning E, O’Rahilly S, Bottolo L, Farooqi IS. Leptin-mediated Changes in the Human Metabolome. Journal of Clinical Endocrinology and Metabolism. Volume 105, Issue 8, August 2020. PMID: 32392278.
- Leelarathna L, Thabit H, Hovorka R, Evans M. Estimated HbA 1c and glucose management indi- cator (GMI): are they the same? Diabet Med. 2020 Oct 15;e14423. PMID: 33058254.
- Lewis JE, Miedzybrodzka EL, Foreman RE, Woodward ORM, Kay RG, Goldspink DA, Gribble FM, Reimann F. Selective stimulation of colonic L cells improves metabolic outcomes in mice. Diabetologia. 2020 Apr 27. PMID: 32342115.
- Leelarathna L, Thabit H, Willinska ME, Bally L, Mader JK, Arnolds S, Benesch C, Pieber TR, Shah VN, Carlson AL, Bergenstal RM, Evans ML, Hovorka R; AP@home04 and APCam11 consortia. Duration of Hybrid Closed-Loop Insulin Therapy to Achieve Representative Glycemic Outcomes in Adults With Type 1 Diabetes. Diabetes Care. 2020 Jan 16. pii: dc192041. Epub ahead of print. PubMed PMID: 31949086.
- Liang ZS, Cimino I, Yalcin B, Raghupathy N, Vancollie VE, Ibarra-Soria X, Firth HV, Rimmington D, Farooqi IS, Lelliott CJ, Munger SC, O’Rahilly S, Ferguson-Smith AC, Coll, Logan DW. Trappc9 deficiency causes parent-of-origin dependent microcephaly and obesity. Plos Genetics. 2020 Sept 2. PMID: 32877400 PMC7467316.
- Lockhart S, O’Rahilly S. When two pandemics meet: Why is obesity associated with increased COVID-19 mortality. Med. 25 June 2020.
- Lockhart SM, Saudek V, O’Rahilly S. GDF15: A hormone conveying somatic distress to the brain. Endocrine Reviews. Vol 41 Issue 4 2020 Apr 20. PMID: 32310257. Lockhart SM, O’Rahilly S. The wasting hormone GDF15 frees up fat to fight infection. Nature Metabolism 2019;1:935-936 (news and views).
- Löfvenborg JE, Carlsson S, Andersson T, Hampe CS, Koulman A, Chirlaque Lopez MD, Jakszyn P, Katzke VA, Kühn T, Kyrø C, Masala G, Nilsson PM, Overvad K, Panico S, Sánchez MJ, van der Schouw Y, Schulze MB, Tjønneland A, Weiderpass E, Riboli E, Forouhi NG, Sharp SJ, Rolandsson O, Wareham NJ. Interaction Between GAD65 Antibodies and Dietary Fish Intake or Plasma Phospholipid n-3 Polyunsaturated Fatty Acids on Incident Adult-Onset Diabetes: The EPIC-InterAct Study. Diabetes Care. 2020 Dec 10;dc201463. doi: 10.2337/dc20-1463. PMID: 33303636.
- Lu Y, Basatemur G, Scott IC, Chiarugi, D, Clement M, Harrison J, Jugdaohsingh R, Yu X, Newland SA, Jolin HE, Li X, Chen X, Szymanska M, Haraldsen G, Palmer G, Fallon PG, Cohen ES, McKenzie ANJ, Mallat Z. Interleukin-33 Signaling Controls the Development of Iron-Recycling Macrophages. Immunity 52, 782-793.e5. PMID:32272082 PMCID:PMC7237885
- Lund ML , Sorrentino G, Egerod KL, Kroone C, Mortensen B, Knop FK, Reimann F, Gribble FM, Drucker DJ, de Koning EJP, Schoonjans K, Bäckhed F, Schwartz TW, Petersen N (2020) L-cell differentiation is induced by bile acids through GLP-1 and paracrine serotonin signaling. Diabetes 2020 Apr;69(4):614-623. doi: 10.2337/db19-0764. Epub 2020 Feb 10. PMID: 32041793 PMCID: PMC7224989
- Ma Y, Ratnasabapathy R, De Backer I, Izzi-Engbeaya C, Nguyen-Tu MS, Cuenco J, Jones B, John CD, Lam BY, Rutter GA, Yeo GS, Dhillo WS, Gardiner J. Glucose in the hypothalamic paraventricular nucleus regulates GLP-1 release. JCI Insight. 2020 Mar 31;5(8):e132760. doi: 10.1172/jci.insight.132760. PMID:32229720 PMCID:PMC7205434
- MacFarlane J, Bashari WA, Senanayake R, Gillett D, van der Meulen M, Powlson AS, Kolias A, Koulouri O, Gurnell M. Advances in the Imaging of Pituitary Tumors. Endocrinol Metab Clin North Am. 2020 Sep;49(3):357-373. PMID: 32741476.
- Magee LA, Banerjee A, Coleman MA, von Dadelszen P, Denison F, Farmer A, Finer S, FoxRushby J, Holt R, Lindsay RS, MacKillop L, Maresh M, McAuliffe FM, McCance D, McCarthy FP, Meek CL, Murphy HR, Myers J, Pasupathy D, Poston L, Reynolds RM, Saravanan P, Scott E, Sukumar N, Tan B, Thangaratinam S, Webster L, White SL, Williamson C. Gestational Diabetes Mellitus: An opportunity to improve long term health in mothers and children. Lancet Diabetes and Endocrinology. ISSN 2213-8587 (In Press)
- Mahú I, Barateiro A, Rial-Pensado E, Martinéz-Sánchez N, Vaz SH, Cal PMSD, Jenkins B, Rodrigues T, Cordeiro C, Costa MF, Mendes R, Seixas E, Pereira MMA, Kubasova N, Gres V, Morris I, Temporão C, Olivares M, Sanz Y, Koulman A, Corzana F, Sebastião AM, López M, Bernardes GJL, Domingos AI. Brain-Sparing Sympathofacilitators Mitigate Obesity Without Adverse Cardiovascular Effects. Cell Metabolism. 2020 Jun 2;31(6):1120-1135.e7. PMID: 32402266.
- Marcovecchio ML, Colombo M, Dalton RN, McKeigue PM, Benitez-Aguirre P, Cameron F, Chiesa ST, Couper J, Craig M, Daneman D, Davis E, Deanfield J, Donaghue K, Jones TW, Mahmud FH, Marshall SM, Neil HAW, Colhoun HM, Dunger DB; AdDIT and the SDRNT1BIO Investigators. Biomarkers associated with early stages of kidney disease in adolescents with type 1 diabetes. Pediatr Diabetes. 2020 Aug 11. PMID: 32783254.
- Marcovecchio ML, Gorman S, Watson LPE, Dunger DB, Beardsall K. Catch-Up Growth in Children Born Small for Gestational Age Related to Body Composition and Metabolic Risk at Six Years of Age in the UK. Horm Res Paediatr. 2020 Jul 23;93(2):119-127. PMID: 32702692.
- Marcovecchio ML, Wicker LS, Dunger DB, Dutton SJ, Kopijasz S, Scudder C, Todd JA, Johnson PRV. Interleukin-2 Therapy of Autoimmunity in Diabetes (ITAD): A Phase 2, Multicentre, DoubleBlind, Randomized, Placebo-Controlled Trial. Wellcome Open Res. 2020 Mar 20;5:49. PMID: 32399500. PMCID: PMC7194454.
- Marenne G, Hendricks AE, Perdikari A, Bounds R, Payne F, Keogh JM, Lelliott CJ, Henning E, Pathan S, Ashford S, Bochukova EG, Mistry V, Daly A, Hayward C; INTERVAL, UK10K Consortium, Wareham NJ, O’Rahilly S, Langenberg C, Wheeler E, Zeggini E, Farooqi IS, Barroso I. Exome Sequencing Identifies Genes and Gene Sets Contributing to Severe Childhood Obesity, Linking PHIP Variants to Repressed POMC Transcription. Cell Metabolism. 2020 Jun 2;31 (6):1107-1119.e12. PMID: 32492392.
- Marques P, Caimari F, Hernández-Ramírez LC, Collier D, Iacovazzo D, Ronaldson A, Magid K, Lim CT, Stals K, Ellard S, Grossman AB, Korbonits M; FIPA Consortium. Significant Benefits of AIP Testing and Clinical Screening in Familial Isolated and Young-onset Pituitary Tumors. Journal of Clinical Endocrinology and Metabolism. 2020 Jun 1;105(6):dgaa040. PMID: 31996917 PMCID: PMC7137887.
- Mazarello Paes V, Barrett JK, Dunger DB, Gevers EF, Taylor-Robinson DC, Viner RM, Stephenson TJ. Factors predicting poor glycemic control in the first two years of childhood onset type 1 diabetes in a cohort from East London, UK: Analyses using mixed effects fractional polynomial models. Pediatr Diabetes. 2020 Mar;21(2):288-299. Epub 2019 Dec 17. PubMed PMID:31782879.
- Meek CL, Devoy B, Simmons D, Patient CJ, Aiken AR, Murphy HR, Aiken CE. Seasonal variations in incidence and maternal-fetal outcomes of gestational diabetes. Diabet Med. 2020 Apr;37(4):674-680. doi: 10.1111/dme.14236. PMID:31955458
- Meek CL, Lewis HB, Burling K, Reimann F, Gribble F. Expected values for gastrointestinal and pancreatic hormone concentrations in healthy volunteers in the fasting and postprandial state. Ann Clin Biochem. 2020 Dec 7;4563220975658. doi: 10.1177/0004563220975658. PMID: 33175577.
- Meek CL, Lindsay RS, Scott EM, Aiken CE, Myers J, Reynolds R, Simmons D, Yamamoto JM, McCance DR, Murphy HR. Approaches to screening for hyperglycaemia in pregnant women during and after the Covid-19 pandemic. Diabet Med. 2020 Aug 4. PMID: 32750184
- Melvin A, Cowan C, Lam B, Buller S, Rainbow K, Yeo GS, O’Rahilly S. SUN-LB107 Functional Characterisation of Human Heterozygous Non-Synonymous MC3R Variants. Journal of the Endocrine Society, Volume 4, Issue Supplement_1, April-May 2020.
- Miedzybrodzka EL, Foreman RE, Galvin SG, Larraufie P, George AL, Goldspink DA, Reimann F, Gribble FM, Kay RG. Organoid Sample Preparation and Extraction for LC-MS Peptidomics. STAR Protoc. 2020 Nov 25;1(3):100164. doi: 10.1016/j.xpro.2020.100164. PMID:33377058 PMCID:PMC7757358
- Mlcochova P, Collier D, Ritchie A, Assennato SM, Hosmillo M, Goel N, Mend B, Chatterjee K, Mendoza V, Temperton N, Kiss L, James LC, Ciazynska KA, Xiong X, Briggs JAG, Nathan JA, Mescia F, Bergamaschi L, Zhang H, Barmpounakis P, Demeris N, Skells R, Lyons PA, Bradley J, Baker S, Allain JP, Smith KGC, Bousfield R, Wilson M, Sparkes D, Amoroso G, Gkrania-Klotsas E, Hardwick S, Boyle A, Goodfellow I, Gupta RK. Combined point-of-care nucleic acid and antibody testing for SARS-COV2 following emergence of D614G spike variant. Cell Reports Medicine 2020; doi: 10.1016/j.xcrm.2020.100099. PMID:32905045 PMCID:PMC7462534
- Modvig I, Andersen D, Grunddal K, Kuhre RE, Martinussen C, Christiansen C, Ørskov C, Larraufie P, Kay RG, Reimann F, Gribble FM, Hartmann B, Bojsen-Møller K, Madsbad S, Wewer Albrechtsen N, Holst JJ (2020) Secretin release after Roux-en-Y Gastric Bypass reveals a population of glucose-sensitive S-cells in distal small intestine. Int J Obes (Lond). 2020 Feb 3. doi: 10.1038/s41366-020-0541-7. PMID: 32015474
- Montagnese M, Knolle F, Haarsma J, Griffin JD, Richards A, Vertes PE, Kiddle B, Fletcher PC, Jones PB, Owen MJ, Fonagy P, Bullmore ET, Dolan RJ; NSPN Consortium, Moutoussis M, Goodyer IM, Murray GK. Reinforcement Learning as an Intermediate Phenotype in Psychosis? Deficits Sensitive to Illness Stage but Not Associated With Polygenic Risk of Schizophrenia in the General Population. Schizophrenia Research. 2020 May 7:S0920-9964(20)30229-2. PMID: 32389614.
- Moran C, Seger C, Taylor K, Oddy S, Burling K, Rajanayagam O, Fairall L, McGowan AN, Lyons G, Halsall D, Gurnell M, Schwabe J, Chatterjee VK, Strey C. HYPERTHYROXINEMIA AND HYPERCORTISOLEMIA DUE TO FAMILIAL DYSALBUMINEMIA. Thyroid. 2020 Jul 15. PMID: 32669045.
- Napier C, Gan EH, Mitchell AL, Gilligan LC, Rees DA, Moran C, Chatterjee K, Vaidya B, James RA, Mamoojee Y, Ashwell S, Arlt W, Pearce SHS. Residual Adrenal Function in Autoimmune Addison’s Disease-Effect of Dual Therapy With Rituximab and Depot Tetracosactide. J Clin Endocrinol Metab. 2020 Apr 1;105(4). PMID: 31863094. PMCID: PMC7067544.
- Niechciał E, Acerini CL, Chiesa ST, Stevens T, Dalton RN, Daneman D, Deanfield JE, Jones TW, Mahmud FH, Marshall SM, Neil HAW, Dunger DB, Marcovecchio ML; Adolescent Type 1 Diabetes Cardio-Renal Intervention Trial (AdDIT) Study Group; Medication Adherence During Adjunct Therapy With Statins and ACE Inhibitors in Adolescents With Type 1 Diabetes. Diabetes Care. 2020 May;43(5):1070-1076. PMID: 32108022.
- Nicholas, L., Nagao, M., Kusinski, L., Twinn, D., Eliasson, L., & Ozanne, S. (2020). Exposure to maternal obesity programs sex differences in pancreatic islets of the offspring in mice. Diabetologia, 63 (2), 324-337. PMID: 31773193. PMCID: PMC6946752.
- Ong KK, Cheng TS, Olga L, Prentice PM, Petry CJ, Hughes IA, Dunger DB. Which Infancy Growth Parameters Are Associated With Later Adiposity? The Cambridge Baby Growth Study. Annals of Human Biology. 2020 Mar;47(2):142-149. PMID: 32429763.
- Petry CJ, Ong KK, Hughes IA, Dunger DB. Multiple Micronutrient Supplementation during Pregnancy and Increased Birth Weight and Skinfold Thicknesses in the Offspring: The Cambridge Baby Growth Study. Nutrients. 2020 Nov 12;12(11):3466. doi: 10.3390/nu12113466. PMID: 33198145 PMCID: PMC7697774.
- Prins D, Park HJ, Watcham S, Li J, Vacca M, Bastos HP, Gerbaulet A, Vidal-Puig A, Göttgens B, Green AR. The stem/progenitor landscape is reshaped in a mouse model of essential thrombocythemia and causes excess megakaryocyte production. Sci Adv. 2020 Nov 25;6(48):eabd3139. doi: 10.1126/sciadv.abd3139. PMID: 33239297 PMCID: PMC7688335
- Razolli DS, de Araújo TM, Sant Apos Ana MR, Kirwan P, Cintra DE, Merkle FT, Velloso LA. Proopiomelanocortin Processing in the Hypothalamus Is Directly Regulated by Saturated Fat: Implications for the Development of Obesity. Neuroendocrinology. 2020;110(1-2):92-104. Epub 2019 May20. PubMed PMID: 31104058.
- Quinn M, Bashari W, Smith D, Gurnell M, Agha A. A remarkable case of thyrotoxicosis initially caused by graves’ disease followed by a probable TSHoma – a case report. BMC Endocr Disord. 2020 Aug 27;20(1):133. PMID: 32854689 PMC7457301.
- Reimann, F., Lewis, J. E., Miedzybrodzka, E. L., Foreman, R. E., Woodward, O. R., Kay, R. G., Goldspink, D. A., & et al. Selective stimulation of colonic L-cells improves metabolic outcomes in mice. Diabetologia. 2020 Jul;63(7):1396-1407. doi: 10.1007/s00125-020-05149-w. Epub 2020 Apr 27. PMID: 32342115 PMCID: PMC7286941
- Roseboom TJ, Ozanne SE, Godfrey KM, Isasi CR, Itoh H, Simmons R, Bansal A, Barker M, Plosch T, Sloboda DM, Matthews SG, Fall CHD, Poston L, Hanson MA. Unheard, unseen and unprotected: DOHaD council’s call for action to protect the younger generation from the long- term effects of COVID-19. J Dev Orig Health Dis. 2020 Sep 23;1-3. PMID: 32962780.
- Roth E, Benoit S, Quentin B, Lam B, Will S, Ma M, Heeley N, Darwish T, Shrestha Y, Gribble F, Reimann F, Pshenichnaya I, Yeo G, Baker DJ, Trevaskis JL, Blouet C. Behavioural and neurochemical mechanisms underpinning the feeding-suppressive effect of GLP-1/CCK combinatorial therapy. Mol Metab. 2020 Nov 19;43:101118. doi: 10.1016/j.molmet.2020.101118. PMID: 33221554 PMCID: PMC7720077.
- Rowitch DH, O’Rahilly S, Smith GCS. A classification of video-conferencing related illness: the zoomnotic diseases. QJM. 2020 Nov 27;hcaa316. doi: 10.1093/qjmed/hcaa316. PMID: 33245119
- Rubio C, Puerto M, García-Rodríquez JJ, Lu VB, García-Martínez I, Alén R, Sanmartín-Salinas P, Toledo-Lobo MV, Saiz J, Ruperez J, Barbas C, Menchén L, Gribble FM, Reimann F, Guijarro LG, Carrascosa JM, Valverde ÁM. Impact of global PTP1B deficiency on the gut barrier permeability during NASH in mice. Mol Metab. 2020 Feb 6;35:100954. PMID: 32244182. PMCID: PMC7082558.
- Sam AH, Reid MD, Thakerar V, Gurnell M, Westacott R, Reed MWR, Brown CA. National inter-rater agreement of standardised simulated-patient-based assessments. Med Teach. 2020 Nov 16;1-6. doi: 10.1080/0142159X.2020.1845909. PMID: 33198538.
- Samuelson I, Vidal-Puig A. Studying Brown Adipose Tissue in a Human in vitro Context. Front Endocrinol (Lausanne). 2020 Sep 15;11:629. PMID: 33042008 PMC7523498.
- Sarnobat D, Moffett C R, Gault V A, Tanday N, Reimann F, Gribble F M, Flatt P R, Irwin N. Effects of long-acting GIP, xenin and oxyntomodulin peptide analogues on alpha-cell transdifferentiation in insulin-deficient diabetic GluCreERT2;ROSA26-eYFP mice. Peptides. 2020 Mar;125:170205 Review. PMID: 31738969 PMCID: PMC7212078
- Sarnobat D, Moffett CR, Tanday N, Reimann F, Gribble FM, Flatt PR, Tarasov AI. Antidiabetic drug therapy alleviates type 1 diabetes in mice by promoting pancreatic α-cell transdifferentia- tion. Biochem Pharmacol. 2020 Sep 11;182:114216. PMID: 32926875.
- Schoenmakers E, Chatterjee K. Human disorders affecting the selenocysteine incorporation pathway cause systemic selenoprotein deficiency. Antioxididants and Redox Signalling. 2020 May 11. PMID: 32295391.
- Smith LE, Mottershaw AL, Egan M, Waller J, Marteau TM, Rubin GJ. The impact of believing you have had COVID-19 on self-reported behaviour: Cross-sectional survey. PLoS One. 2020 Nov 4;15(11):e0240399. doi: 10.1371/journal.pone.0240399. PMID: 33147219 PMCID: PMC7641362
- Snowden SG, Fernandes HJR, Kent J, Foskolou S, Tate P, Field SF, Metzakopian E, Koulman A. Development and Application of High-Throughput Single Cell Lipid Profiling: A Study of SNCA-A53T Human Dopamine Neurons. iScience. 2020 Oct 21;23(11):101703. doi: 10.1016/j.isci.2020.101703. eCollection 2020 Nov 20. PMID: 33196026 PMCID: PMC7644967.
- Snowden SG, Korosi A, de Rooij SR, Koulman A. Combining lipidomics and machine learning to measure clinical lipids in dried blood spots. Metabolomics. 2020 Jul 24;16(8):83. PMID: 32710150. PMC7381462.
- Sonoyama T, Stadler LKJ, Zhu M, Keogh JM, Henning E, Hisama F, Kirwan P, Jura M, Blaszczyk BK, DeWitt DC, Brouwers B, Hyvönen M, Barroso I, Merkle FT, Appleyard SM, Wayman GA, Farooqi IS. Human BDNF/TrkB Variants Impair Hippocampal Synaptogenesis and Associate With Neurobehavioural Abnormalities. Scientific Reports. 2020 Jun 3;10(1):9028. PMID: 32493978.
- Suehs CM, Menzies-Gow A, Price D, Bleecker ER, Canonica GW, Gurnell M, Bourdin A; Oral Corticosteroids Tapering Delphi Expert Panel. Expert Consensus on the Tapering of Oral Corticosteroids for the Treatment of Asthma: A Delphi Study. Am J Respir Crit Care Med. 2020 Oct 28. doi: 10.1164/rccm.202007-2721OC. PMID: 33112646.
- Sullivan SA, Kounali D, Cannon M, David AS, Fletcher PC, Holmans P, Jones H, Jones PB, Linden DEJ, Lewis G, Owen MJ, O’Donovan M, Rammos A, Thompson A, Wolke D, Heron J, Zammit S. A Population-Based Cohort Study Examining the Incidence and Impact of Psychotic Experiences From Childhood to Adulthood, and Prediction of Psychotic Disorder. Am J Psychiatry. 2020 Jan 7. Epub ahead of print. PubMed PMID: 31906710.
- Tarry-Adkins JL, Aiken CE, Ozanne SE. Comparative Impact of Pharmacological Treatments for Gestational Diabetes on Neonatal Anthropometry Independent of Maternal Glycaemic Control: A Systematic Review and Meta-Analysis. PLoS Med. 2020 May 22;17(5):e1003126. PMID: 32442232 PMCID: PMC7244100.
- Teufel C, Fletcher PC. Publisher Correction: Forms of prediction in the nervous system. Nat Rev Neurosci. 2020 Mar 27. PMID: 32221470
- Teufel C, Fletcher PC. Forms of prediction in the nervous system. Nat Rev Neurosci. 2020 Apr;21(4):231-242. Epub 2020 Mar 10. Review. Erratum in: Nat Rev Neurosci. 2020 Mar 27. PMID: 32157237.
- Teulings NEWD, Wood AM, Sovio U, Ozanne SE, Smith GCS, Aiken CE. Independent influences of maternal obesity and fetal sex on maternal cardiovascular adaptation to pregnancy: a prospective cohort study. Int J Obes (Lond). 2020 Jun 15. PMID: 32765423. PMC7381236.
- Thackray AM, Lam B, Shahira Binti Ab Razak A, Yeo G, Bujdoso R. Transcriptional signature of prion-induced neurotoxicity in a Drosophila model of transmissible mammalian prion disease. Biochem J. 2020 Feb 28;477(4):833-852. PMID: 32108870.
- Tsang AH, Nuzzaci D, Darwish T, Samudrala H, Blouet C. Nutrient sensing in the nucleus of the solitary tract mediates non-aversive suppression of feeding via inhibition of AgRP neurons. Mol Metab. 2020 Sep 6;42:10107. PMID: 32898712 PMC7549147.
- Tung L, O’Rahilly S. Constitutional Thinness: tALKing the tALK or wALKing the wALK? Cell Metabolism, 01 Jul 2020, 32(1):8-10. PMID: 32640247.
- Uter J, Heldmann M, Rogge B, Obst M, Steinhardt J, Brabant G, Moran C, Chatterjee K, Münte TF. Patients with mutations of the Thyroid hormone beta-receptor show an ADHD-like phenotype for performance monitoring: an electrophysiological study. Neuroimage Clin. 2020 Mar 19;26:102250. PMID: 32217468.
- Vacca M, Leslie J, Virtue S, Lam BYH, Govaere O, Tiniakos D, Snow S, Davies S, Petkevicius K, Tong Z, Peirce V, Nielsen MJ, Ament Z, Li W, Kostrzewski T, Leeming DJ, Ratziu V, Allison MED, Anstee QM, Griffin JL, Oakley F, Vidal-Puig A. Bone morphogenetic protein 8B promotes the progression of non-alcoholic steatohepatitis. Nat Metab. 2020 Jun;2(6):514-531. PMID: 32694734.
- Valleriani A, Chiarugi D. A workbench for the translational control of gene expression. bioRxiv 2020.01.28.923219.
- Vergari E, Denwood G, Salehi A, Zhang Q, Adam J, Alrifaiy A, Wernstedt Asterholm I, Benrick A, Chibalina MV, Eliasson L, Guida C, Hill TG, Hamilton A, Ramracheya R, Reimann F, Rorsman NJG, Spilliotis I, Tarasov AI, Walker JN, Rorsman P, Briant LJB. Somatostatin secretion by Na(+)-dependent Ca(2+)-induced Ca(2+) release in pancreatic delta-cells. Nat Metab. 2020 Jan;2(1):32-40. Epub 2020 Jan 20. PubMed PMID: 31993555; PubMed Central PMCID: PMC6986923.
- Vogelezang S, [31 authors], Farooqi IS, [110 authors]; Early Growth Genetics Consortium, Jad- doe VWV, Grant SFA, Felix JF. Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits. PLoS Genet. 2020 Oct 12;16(10):e1008718. PMID: 33045005.
- von Schnurbein J, Adams C, Akinci B, Ceccarini G, D’Apice MR, Gambineri A, Hennekam RCM, Jeru I, Lattanzi G, Miehle K, Nagel G, Novelli G, Santini F, SantosSilva E, Savage DB, Sbraccia P, Schaaf J, Sorkina E, Tanteles G, Vantyghem MC, Vatier C, Vigouroux C, Vorona E, AraújoVilar D, Wabitsch M. European lipodystrophy registry: background and structure. Orphanet J Rare Dis. 2020 Jan 15;15(1):17. PubMed PMID: 31941540; PubMed Central PMCID: PMC6964101.
- Wagstyl K, Larocque S, Cucurull G, Lepage C, Cohen JP, Bludau S, Palomero-Gallagher N, Lewis LB, Funck T, Spitzer H, Dickscheid T, Fletcher PC, Romero A, Zilles K, Amunts K, Bengio Y, Evans AC. BigBrain 3D Atlas of Cortical Layers: Cortical and Laminar Thickness Gradients Diverge in Sensory and Motor Cortices. PLoS Biol. 2020 Apr 3;18(4):e3000678. PMID: 32243449 PMCID: PMC7159250.
- Wallis N, Raffan E. The Genetic Basis of Obesity and Related Metabolic Diseases in Humans and Companion Animals. Genes (Basel). 2020 Nov 20;11(11):1378. doi: 10.3390/genes11111378. PMID:33233816 PMCID:PMC7699880
- Warde KM, Schoenmakers E, Ribes Martínez E, Lim YJ, Leonard M, Lawless SJ, O’Shea P, Chatterjee VK, Gurnell M, Hantel C, Dennedy MC. Liver X receptor inhibition potentiates mitotane induced adrenotoxicity in ACC. Endocrine Related Cancer. Vol 27 (Issue 6) pp 361-373. 2020 June. PMID: 32276262.
- Wargent ET, Martin-Gronert MS, Cripps RL, Heisler LK, Yeo GSH, Ozanne SE, Arch JRS, Stocker CJ. Developmental programming of appetite and growth in male rats increases hypothalamic serotonin (5-HT)5A receptor expression and sensitivity. Int J Obes (Lond). 2020 Jul 27. PMID: 32719434.
- Webb TL, du Plessis H, Christian H, Raffan E, Rohlf V, White GA. Understanding obesity among companion dogs: New measures of owner’s beliefs and behaviour and associations with body condition scores. Prev Vet Med. 2020 Jul;180:105029. doi: 10.1016/j.prevetmed.2020. PMID:32474335
- Westwater ML, Mancini F, Shapleske J, Serfontein J, Ernst M, Ziauddeen H, Fletcher PC. Dissociable Hormonal Profiles for Psychopathology and Stress in Anorexia and Bulimia Nervosa. Psychological Medicine. 2020 May 28:1-11. PMID: 32460904.
- Wood CL, Cole M, Donaldson M, Dunger DB, Wood R, Morrison N, Matthews JNS, Pearce SHS, Cheetham TD. Randomised trial of block and replace vs dose titration thionamide in young people with thyrotoxicosis. Eur J Endocrinol. 2020 Dec;183(6):637-645. doi: 10.1530/EJE-20-0617. PMID: 33107439.
- Worth AA, Shoop R, Tye K, Feetham CH, D’Agostino G, Dodd GT, Reimann F, Gribble FM, Beebe EC, Dunbar JD, Alexander-Chacko JT, Sindelar DK, Coskun T, Emmerson PJ, Luckman SM. The cytokine GDF15 signals through a population of brainstem cholecystokinin neurons to mediate anorectic signalling. Elife. 2020 Jul 29;9:e55164. PMID: 32723474. PMC7410488.
- Yeo CR, Agrawal M, Hoon S, Shabbir A, Shrivastava MK, Huang S, Khoo CM, Chhay V, Shabeer M, Shyong Tai E, Vidal-Puig A, Toh SA. Reply to: ‘Browning capabilities of human primary adipose-derived stromal cells compared to SGBS cells’. Sci Rep. 2020 Jun 15;10(1):9634. PMID: 32541770. PMC7295789.
- Zangemeister L, Grabenhorst F, Schultz W. Neural activity in human ventromedial prefrontal cortex reflecting the intention to save reward. Soc Cogn Affect Neurosci. 2020 Jan 28. Epub ahead of print. PubMed PMID: 31993656.
2019
- Adriaensses A; Gribble FM; Reimann F. The glucose-dependent insulinotropic polypeptide signalling axis in the central nervous system. Peptides. 2020 Mar;125:170194. Epub 2019 Nov 4. Review. PMID: 31697967
- Adriaenssens AE, Biggs EK, Darwish T, Tadross J, Sukthankar T, Girish M, Polex-Wolf J, Lam BY, Zvetkova I, Pan W, Chiarugi D, Yeo GSH, Blouet C, Gribble FM, Reimann F. GlucoseDependent Insulinotropic Polypeptide Receptor-Expressing Cells in the Hypothalamus Regulate Food Intake. Cell Metab. 2019 Aug 19. [Epub ahead of print] PMID: 31447324.
- Ahmed RM, Landin-Romero R, Liang CT, Keogh JM, Henning E, Strikwerda-Brown C, Devenney EM, Hodges JR, Kiernan MC, Farooqi IS, Piguet O. Neural networks associated with body composition in frontotemporal dementia. Ann Clin Transl Neurol. 2019 Sep;6(9):1707-1717. PMID: 31461580.
- Aiken CEM, Hone L, Murphy HR, Meek CL. Improving outcomes in gestational diabetes: does gestational weight gain matter? Diabet Med. 2019 Feb;36(2):167-176. doi: 10.1111/dme.13767. PMID:29932243
- Aiken CE, Tarry-Adkins JL, Ashmore TJ, Ozanne SE. Early life environment influences the trajectory of post-partum weight loss in adult female rats. Reprod Biomed Online. 2019 May;38(5):779-786. doi: 10.1016/j.rbmo.2018.12.002. Epub 2018 Dec 12. PMID: 30885667. PMCID: PMC6491499
- Aiken CE, Tarry-Adkins JL, Ozanne SE. Assaying Reproductive Capacity in Female Rodents. Methods Mol Biol.
2019;1916:157-166. doi: 10.1007/978-1-4939-8994-2_15. PMID: 30535693
- Aiken CE, Tarry-Adkins JL, Spiroski AM, Nuzzo AM, Ashmore TJ, Rolfo A, Sutherland MJ, Camm EJ, Giussani DA, Ozanne SE. Chronic fetal hypoxia disrupts the peri-conceptual environment in nextgeneration adult female rats. J Physiol. 2019 May;597(9):2391-2401. doi: 10.1113/JP277431. Epub 2019 Mar 24. PMID: 30791124 PMCID: PMC6487938
- Aiken CE, Tarry-Adkins JL, Spiroski AM, Nuzzo AM, Ashmore TJ, Rolfo A, Sutherland MJ, Camm EJ, Giussani DA, Ozanne SE. Chronic gestational hypoxia accelerates ovarian aging and lowers ovarian reserve in next-generation adult rats. FASEB J. 2019 Jun;33(6):7758-7766. doi: 10.1096/fj.201802772R. Epub 2019 Mar 19. PMID: 30888848 PMCID: PMC6529349
- Ajjaji D, Ben M’barek K, Mimmack ML, England C, Herscovitz H, Dong L, Kay RG, Patel S, Saudek V, Small DM, Savage DB, Thiam AR. Dual binding motifs underpin the hierarchical association of perilipins1 -3 with lipid droplets. Mol Biol Cell. 2019 Mar 1;30(5):703-716. doi: 10.1091/mbc.E18-08-0534. Epub 2019 Jan 16. PMID: 30649995 PMCID: PMC6589688
- Al-Massadi O, Quiñones M, Clasadonte J, Hernandez-Bautista R, Romero-Picó A, Folgueira C, Morgan DA, Kalló I, Heras V, Senra A, Funderburk SC, Krashes MJ, Souto Y, Fidalgo M, Luquet S, Chee MJ, Imbernon M, Beiroa D, García-Caballero L, Gallego R, Lam BYH, Yeo G, Lopez M, Liposits Z, Rahmouni K, Prevot V, Dieguez C, Nogueiras R. MCH Regulates SIRT1/FoxO1 and Reduces POMC Neuronal Activity to Induce Hyperphagia, Adiposity, and Glucose Intolerance. Diabetes. 2019 Dec;68(12):2210-2222. Epub 2019 Sep 16. PubMed PMID:31530579; PubMed Central PMCID: PMC6868473.
-
Araiz C, Yan A, Bettedi L, Samuelson I, Virtue S, McGavigan AK, Dani C, Vidal-Puig A, Foukas LC. Enhanced β-adrenergic signalling underlies an age-dependent beneficial metabolic effect of PI3K p110α inactivation in adipose tissue. Nat Commun. 2019 Apr 4;10(1):1546. PMID:30948720
-
Ast J, Arvaniti A, Fine NHF, Nasteska D, Ashford FB, Stamataki Z, Koszegi Z, Bacon A, Jones BJ, Lucey MA, Sasaki S, Brierley DI, Hastoy B, Tomas A, D’Agostino G, Reimann F, Lynn FC, Reissaus CA, Linnemann AK, D’Este E, Calebiro D, Trapp S, Johnsson K, Podewin T, Broichhagen J, Hodson DJ. Super-resolution microscopy compatible fluorescent probes reveal endogenous glucagon-like peptide-1 receptor distribution and dynamics. Nat Commun. 2020 Jan 24;11 (1):467. PubMed PMID: 31980626; PubMed Central PMCID: PMC6981144.
-
Badenes M, Amin A, González-García I, Félix I, Burbridge E, Cavadas M, Ortega FJ, de Carvalho É, Faísca P, Carobbio S, Seixas E, Pedroso D, Neves-Costa A, Moita LF, Fernández-Real JM, Vidal-Puig A, Domingos A, López M, Adrain C. Deletion of iRhom2 protects against dietinduced obesity by increasing thermogenesis. Mol Metab. 2020 Jan;31:67-84.Epub 2019 Oct 31. PubMed PMID: 31918923; PubMed Central PMCID: PMC6909339.
-
Baig S, Parvaresh Rizi E, Chia C, Shabeer M, Aung N, Loh TP, Magkos F, Vidal-Puig A, Seet RCS, Khoo CM, Toh SA. Genes Involved in Oxidative Stress Pathways Are Differentially Expressed in Circulating Mononuclear Cells Derived From Obese Insulin-Resistant and Lean Insulin-Sensitive Individuals Following a Single Mixed-Meal Challenge. Front Endocrinol (Lausanne). 2019 Apr 24;10:256. eCollection 2019. PMID:31068904 PubMed Central PMCID:PMC6491694
-
Bally L, Gubler P, Thabit H, Hartnell S, Ruan Y, Wilinska ME, Evans ML, Semmo M, Vogt B, Coll AP, Stettler C, Hovorka R. Fully closed-loop insulin delivery improves glucose control of inpatients with type 2 diabetes receiving hemodialysis. Kidney Int. 2019 Sep;96(3):593-596. PMID: 31133457.
-
Bally L, Herzig D, Ruan Y, Wilinska ME, Semmo M, Vogt A, Wertli MM, Vogt B, Stettler C, Hovorka R. Short-term fully closed-loop insulin delivery using faster insulin aspart compared with standard insulin aspart in type 2 diabetes. Diabetes Obes Metab. 2019 Aug 28. [Epub ahead of print] PMID: 31464063.
-
Barbosa AD, Lim K, Mari M, Edgar JR, Gal L, Sterk P, Jenkins BJ, Koulman A, Savage DB, Schuldiner M, Reggiori F, Wigge PA, Siniossoglou S. Compartmentalized Synthesis of Triacylglycerol at the Inner Nuclear Membrane Regulates Nuclear Organization. Dev Cell. 2019 Sep 23;50(6):755-766.e6. PMID: 31422915.
-
Bariana TK, Labarque V, Heremans J, Thys C, De Reys M, Greene D, Jenkins B, Grassi L, Seyres D, Burden F, Whitehorn D, Shamardina O, Papadia S, Gomez K, BioResource N, Van Geet C, Koulman A, Ouwehand WH, Ghevaert C, Frontini M, Turro E, Freson K. Sphingolipid dysregulation due to lack of functional KDSR impairs proplatelet formation causing thrombocytopenia. Haematologica. 2019 May;104(5):1036-1045. Epub 2018 Nov 22. PMID:30467204 PubMed Central PMCID:PMC6518879
-
Bashari WA, Senanayake R, Fernández-Pombo A, Gillett D, Koulouri O, Powlson AS, Matys T, Scoffings D, Cheow H, Mendichovszky I, Gurnell M. Modern imaging of pituitary adenomas. Best Pract Res Clin Endocrinol Metab. 2019 May 28. [Epub ahead of print] Review. PMID:31208872
-
Battelino T, Danne T, Bergenstal RM, Amiel SA, Beck R, Biester T, Bosi E, Buckingham BA, Cefalu WT, Close KL, Cobelli C, Dassau E, DeVries JH, Donaghue KC, Dovc K, Doyle FJ 3rd, Garg S, Grunberger G, Heller S, Heinemann L, Hirsch IB, Hovorka R, Jia W, Kordonouri O, Kovatchev B, Kowalski A, Laffel L, Levine B, Mayorov A, Mathieu C, Murphy HR, Nimri R, Nørgaard K, Parkin CG, Renard E, Rodbard D, Saboo B, Schatz D, Stoner K, Urakami T, Weinzimer SA, Phillip M. Clinical Targets for Continuous Glucose Monitoring Data Interpretation: Recommendations From the International Consensus on Time in Range. Diabetes Care. 2019 Aug;42(8):1593-1603. Epub 2019 Jun 8. Review. PMID:31177185 PubMed Central PMCID:PMC6973648
-
Beardsall K, Thomson L, Elleri D, Dunger DB, Hovorka R. Feasibility of automated insulin delivery guided by continuous glucose monitoring in preterm infants. Arch Dis Child Fetal Neonatal Ed. 2019 Aug 9. pii: fetalneonatal-2019-316871. [Epub ahead of print] PMID: 31399480.
-
Biancolin AD, Martchenko A, Mitova E, Gurges P, Michalchyshyn E, Chalmers JA, Doria A, Mychaleckyj JC, Adriaenssens AE, Reimann F, Gribble FM, Gil-Lozano M, Cox BJ, Brubaker PL. The core clock gene, Bmal1, and its downstream target, the SNARE regulatory protein secretagogin, are necessary for circadian secretion of glucagon-like peptide-1. Mol Metab. 2020 Jan;31:124-137. Epub 2019 Nov 21. PubMed PMID: 31918914; PubMed Central PMCID: PMC6920326.
-
Boughton CK, Bally L, Hartnell S, Wilinska M, Coll AP, Evans M, Stettler C, Hovorka R. Closedloop insulin delivery in end-of-life care: a case report. Diabet Med. 2019 Apr 19. [Epub ahead of print] PMID: 31002426.
-
Boughton CK, Bally L, Hovorka R. Closed-loop management of inpatient hyperglycemia. Aging (Albany NY). 2019 Aug 8;11(15):5292-5293. PMID: 31395790
-
Boughton CK, Bally L, Martignoni F, Hartnell S, Herzig D, Vogt A, Wertli MM, Wilinska ME, Evans ML, Coll AP, Stettler C, Hovorka R. Fully closed-loop insulin delivery in inpatients receiving nutritional support: a two-centre, open-label, randomised controlled trial. Lancet Diabetes Endocrinol. 2019 May;7(5):368-377. Epub 2019 Mar 29. PMID:30935872 PubMed Central PMCID:PMC6467839
-
Boughton CK, Hartnell S, Allen JM, Hovorka R. The importance of prandial insulin bolus timing with hybrid closed-loop systems. Diabet Med. 2019 Aug 23. [Epub ahead of print] PMID: 31441093.
-
Boughton CK, Hovorka R. Advances in artificial pancreas systems. Sci Transl Med. 2019 Mar 20;11(484):eaaw4949. doi: 10.1126/scitranslmed.aaw4949. PMID: 30894501
-
Broekema MF, Savage DB, Monajemi H, Kalkhoven E. Gene-gene and gene-environment interactions in lipodystrophy: Lessons learned from natural PPARγ mutants. Biochim Biophys Acta Mol Cell Biol Lipids. 2019 May;1864(5):715-732. Review. PMID: 30742913
-
Chiesa ST, Charakida M, McLoughlin E, Nguyen HC, Georgiopoulos G, Motran L, Elia Y, Marcovecchio ML, Dunger DB, Dalton RN, Daneman D, Sochett E, Mahmud FH, Deanfield JE. Elevated high-density lipoprotein in adolescents with Type 1 diabetes is associated with endothelial dysfunction in the presence of systemic inflammation. Eur Heart J. 2019 Nov 14;40(43):3559-3566. doi: 10.1093/eurheartj/ehz114. PMID: 30863865 PMCID: PMC6855140
-
Clément M, Raffort J, Lareyre F, Tsiantoulas D, Newland SA, Lu Y, Masters L, Harrison J, Saveljeva S, Ma MK, Ozsvar-Kozma M, Lam B, Yeo GS, Binder CJ, Kaser A, Mallat Z. Impaired Autophagy in CD11b(+) Dendritic Cells Expands CD4(+) Regulatory T Cells And Limits Atherosclerosis in Mice. Circ Res. 2019 Oct 15. [Epub ahead of print] PMID: 31610723.
-
Coll AP, Chen M, Taskar P, Rimmington D, Patel S, Tadross J, Cimino I, Tung YCL, Miedzybrodzka E, Welsh P, Virtue S, Rodriguez-Cuenca S, Yang M, Goldspink DA, Tomaz RA, Harding HP, Melvin A, Yeo GSH, Preiss D, Vidal-Puig A, Vallier L, Ron D, Gribble FM, Reimann F, Sattar N, Savage DB, Allan BB, O’Rahilly S. GDF15 and the beneficial actions of metformin in pre-diabetes. Nature. 2019 Dec 25. Epub ahead of print PMID: 31875646.
-
Colombo M, Valo E, McGurnaghan SJ, Sandholm N, Blackbourn LAK, Dalton RN, Dunger D, Groop PH, McKeigue PM, Forsblom C, Colhoun HM; FinnDiane Study Group and the Scottish Diabetes Research Network (SDRN) Type 1 Bioresource Collaboration. Biomarker panels associated with progression of renal disease in type 1 diabetes. Diabetologia. 2019 Jun 20. [Epub ahead of print] PMID:31222504; PubMed Central ID: PMC6677704
-
Cyranka M, Veprik A, McKay EJ, van Loon N, Thijsse A, Cotter L, Hare N, Saibudeen A, Lingam S, Pires E, Larraufie P, Reimann F, Gribble F, Stewart M, Bentley E, Lear P, McCullagh J, Cantley J, Cox RD, de Wet H. Abcc5 Knockout Mice Have Lower Fat Mass and Increased Levels of Circulating GLP-1. Obesity (Silver Spring). 2019 Aug;27(8):1292-1304. PMID: 31338999; PubMed Central ID: PMC6658130
-
Dovc K, Boughton C, Tauschmann M, Thabit H, Bally L, Allen JM, Acerini CL, Arnolds S, de Beaufort C, Bergenstal RM, Campbell F, Criego A, Dunger DB, Elleri D, Evans ML, FröhlichReiterer E, Hofer S, Kapellen T, Leelarathna L, Pieber TR, Rami-Merhar B, Shah VN, Sibayan J, Wilinska ME, Hovorka R; APCam11, AP@Home, and KidsAP Consortia. Young Children Have Higher Variability of Insulin Requirements: Observations During Hybrid Closed-Loop Insulin Delivery. Diabetes Care. 2019 Jul;42(7):1344-1347. Epub 2019 May 21. PubMed ID: 31221700; PubMed Central ID: PMC6609966
-
Dye FS, Larraufie P, Kay R, Darwish T, Rievaj J, Goldspink DA, Meek CL, Middleton SJ, Hardwick RH, Roberts GP, Percival-Alwyn JL, Vaughan T, Ferraro F, Challis BG, O’Rahilly S, Groves M, Gribble FM, Reimann F. Characterisation of proguanylin expressing cells in the intestine – evidence for constitutive luminal secretion. Sci Rep. 2019 Oct 30;9(1):15574. PubMed ID: 31666564; PubMed Central ID: PMC6821700.
-
Evans ML, Golubic R. Technology to overcome clinical inertia in insulin therapy. Lancet. 2019 Mar 16;393(10176):1078-1080. PMID: 30808513
-
Evans M, Welsh Z, Ells S, Seibold A. The Impact of Flash Glucose Monitoring on Glycaemic Control as Measured by HbA1c: A Meta-analysis of Clinical Trials and Real-World Observational Studies. Diabetes Ther. 2020 Jan;11(1):83-95. Epub 2019 Oct 31. PubMed PMID: 31673972; PubMed Central PMCID: PMC6965602.
-
Fernandez-Twinn DS, Hjort L, Novakovic B, Ozanne SE, Saffery R. Intrauterine programming of obesity and type 2 diabetes. Diabetologia. 2019 Oct;62(10):1789-1801. Review. PMID: 31451874.
-
Flatt AJS, Little SA, Speight J, Leelarathna L, Walkinshaw E, Tan HK, Bowes A, LubinaSolomon A, Holmes-Truscott E, Chadwick TJ, Wood R, McDonald TJ, Kerr D, Flanagan D, Brooks A, Heller SR, Evans ML, Shaw JAM. Predictors of Recurrent Severe Hypoglycemia in Adults With Type 1 Diabetes and Impaired Awareness of Hypoglycemia During the HypoCOMPaSS Study. Diabetes Care. 2019 Sep 4. [Epub ahead of print] PMID: 31484666.
-
Fletcher PC, Kenny PJ. Correction: Food addiction: a valid concept? Neuropsychopharmacology. 2019 Mar;44(4):834. doi: 10.1038/s41386-018-0288-1. PMID: 30532060 PMCID: PMC6372676
-
Flores A, Argetsinger LS, Stadler LKJ, Malaga AE, Vander PB, DeSantis LC, Joe RM, Cline JM, Keogh JM, Henning E, Barroso I, Mendes de Oliveira E, Chandrashekar G, Clutter ES, Hu Y, Stuckey J, Farooqi IS, Myers MG Jr, Carter-Su C. Crucial Role of the SH2B1 PH Domain for the Control of Energy Balance. Diabetes. 2019 Nov;68(11):2049-2062. doi: 10.2337/db19-0608. Epub 2019 Aug 22. PubMed PMID: 31439647.
-
Folgueira C, Beiroa D, Porteiro B, Duquenne M, Puighermanal E, Fondevila MF, BarjaFernández S, Gallego R, Hernández-Bautista R, Castelao C, Senra A, Seoane P, Gómez N, Aguiar P, Guallar D, Fidalgo M, Romero-Pico A, Adan R, Blouet C, Labandeira-García JL, Jeanrenaud F, Kallo I, Liposits Z, Salvador J, Prevot V, Dieguez C, Lopez M, Valjent E, Frühbeck G, Seoane LM, Nogueiras R. Hypothalamic dopamine signaling regulates brown fat thermogenesis. Nat Metab. 2019 Aug;1(8):811-829. doi: 10.1038/s42255-019-0099-7. Epub 2019 Aug 19. PubMed PMID: 31579887; PubMed Central PMCID: PMC6774781.
-
Fretts AM, Imamura F, Marklund M, Micha R, Wu JHY, Murphy RA, Chien KL, McKnight B, Tintle N, Forouhi NG, Qureshi WT, Virtanen JK, Wong K, Wood AC, Lankinen M, Rajaobelina K, Harris TB, Djoussé L, Harris B, Wareham NJ, Steffen LM, Laakso M, Veenstra J, Samieri C, Brouwer IA, Yu CI, Koulman A, Steffen BT, Helmer C, Sotoodehnia N, Siscovick D, Gudnason V; InterAct Consortium, Wagenknecht L, Voutilainen S, Tsai MY, Uusitupa M, Kalsbeek A, Berr C, Mozaffarian D, Lemaitre RN. Associations of circulating very-long-chain saturated fatty acids and incident type 2 diabetes: a pooled analysis of prospective cohort studies. Am J Clin Nutr. 2019 Apr 1;109(4):1216-1223. PubMed PMID: 30982858; PubMed Central PMCID:PMC6500926
-
Furse S, Billing G, Snowden SG, Smith J, Goldberg G, Koulman A. Relationship between the lipid composition of maternal plasma and infant plasma through breast milk. Metabolomics. 2019 Sep 25;15(10):129. doi: 10.1007/s11306-019-1589-z. PubMed PMID: 31555909; PubMed Central PMCID: PMC6761246.
-
Furse S, Koulman A. The Lipid and Glyceride Profiles of Infant Formula Differ by Manufacturer, Region and Date Sold. Nutrients. 2019 May 20;11(5). PubMed PMID:31137537; PubMed Central PMCID: PMC6567151
-
Furse S, Snowden SG, Olga L, Prentice P, Ong KK, Hughes IA, Acerini CL, Dunger DB, Koulman A. Evidence from 3-month-old infants shows that a combination of postnatal feeding and exposures in utero shape lipid metabolism. Sci Rep. 2019 Oct 4;9(1):14321. PubMed PMID: 31586083
-
Furse S, Torres AG, Koulman A. Fermentation of Milk into Yoghurt and Cheese Leads to Contrasting Lipid and Glyceride Profiles. Nutrients. 2019 Sep 11;11(9). pii: E2178. doi: 10.3390/ nu11092178. PubMed PMID: 31514309.
-
Furse S, White SL, Meek CL, Jenkins B, Petry CJ, Vieira MC, Ozanne SE, Dunger DB, Poston L, Koulman A. Altered triglyceride and phospholipid metabolism predates the diagnosis of gestational diabetes in obese pregnancy. Mol Omics. 2019 Dec 2;15(6):420-430. PubMed PMID: 31599289.
-
Gault EJ, Cole TJ, Casey S, Hindmarsh PC, Betts P, Dunger DB, Donaldson MDC. Effect of oxandrolone and timing of pubertal induction on final height in Turner syndrome: final analysis of the UK randomised placebo-controlled trial. Arch Dis Child. 2019 Dec 20. pii: archdischild-2019- 317695. Epub ahead of print. PubMed PMID: 31862699.
-
Giustina A, Barkan A, Beckers A, Biermasz N, Biller BMK, Boguszewski C, Bolanowski M, Bonert V, Bronstein MD, Casanueva FF, Clemmons D, Colao A, Ferone D, Fleseriu M, Frara S, Gadelha MR, Ghigo E, Gurnell M, Heaney AP, Ho K, Ioachimescu A, Katznelson L, Kelestimur F, Kopchick J, Krsek M, Lamberts S, Losa M, Luger A, Maffei P, Marazuela M, Mazziotti G, Mercado M, Mortini P, Neggers S, Pereira AM, Petersenn S, Puig-Domingo M, Salvatori R, Shimon I, Strasburger C, Tsagarakis S, van der Lely AJ, Wass J, Zatelli MC, Melmed S. A Consensus on the Diagnosis and Treatment of Acromegaly Comorbidities: An Update. J Clin Endocrinol Metab. 2019 Oct 13. [Epub ahead of print] PMID: 31606735.
-
Grandoch M, Flögel U, Virtue S, Maier JK, Jelenik T, Kohlmorgen C, Feldmann K, Ostendorf Y, Castañeda TR, Zhou Z, Yamaguchi Y, Nascimento EBM, Sunkari VG, Goy C, Kinzig M, Sörgel F, Bollyky PL, Schrauwen P, Al-Hasani H, Roden M, Keipert S, Vidal-Puig A, Jastroch M, Haendeler J, Fischer JW. 4-Methylumbelliferone improves the thermogenic capacity of brown adipose tissue. Nat Metab. 2019 May;1(5):546-559. PMID: 31602424.
-
Gribble FM, Reimann F. Function and mechanisms of enteroendocrine cells and gut hormones in metabolism. Nat Rev Endocrinol. 2019 Apr;15(4):226-237. doi: 10.1038/s41574-019-0168-8. PMID: 30760847
-
Groeneweg S, Peeters RP, Moran C, Stoupa A, Auriol F, Tonduti D, Dica A, Paone L, Rozenkova K, Malikova J, van der Walt A, de Coo IFM, McGowan A, Lyons G, Aarsen FK, Barca D, van Beynum IM, van der Knoop MM, Jansen J, Manshande M, Lunsing RJ, Nowak S, den Uil CA, Zillikens MC, Visser FE, Vrijmoeth P, de Wit MCY, Wolf NI, Zandstra A, Ambegaonkar G, Singh Y, de Rijke YB, Medici M, Bertini ES, Depoorter S, Lebl J, Cappa M, De Meirleir L, Krude H, Craiu D, Zibordi F, Oliver-Petit I, Polak M, Chatterjee K, Visser TJ, Visser WE. Effectiveness and safety of the tri-iodothyronine analogue Triac in children and adults with MCT8 deficiency: an international, single-arm, open-label, phase 2 trial. Lancet Diabetes Endocrinol. (2019). PMID:31377265
-
Grunnet LG, Pilgaard K, Alibegovic A, Jensen CB, Hjort L, Ozanne SE, Bennett M, Vaag A, Brøns C. Leukocyte telomere length is associated with elevated plasma glucose and HbA1c in young healthy men independent of birth weight. Sci Rep. 2019 May 21;9(1):7639. PMID:31113969. PMC6529491
-
Harshfield EL, Koulman A, Ziemek D, Marney L, Fauman EB, Paul DS, Stacey D, Rasheed A, Lee JJ, Shah N, Jabeen S, Imran A, Abbas S, Hina Z, Qamar N, Mallick NH, Yaqoob Z, Saghir T, Rizvi SNH, Memon A, Rasheed SZ, Memon FU, Qureshi IH, Ishaq M, Frossard P, Danesh J, Saleheen D, Butterworth AS, Wood AM, Griffin JL. An unbiased lipid phenotyping approach to study the genetic determinants of lipids and their association with coronary heart disease risk factors. J Proteome Res. 2019 Jun 7;18(6):2397-2410. doi: 10.1021/acs.jproteome.8b00786. Epub 2019 Apr 26. PMID: 30887811 PMCID: PMC6558644
-
Humphrey JA, Kanthasamy S, Coughlin P, Coll AP, Robinson AAH. Outcome of transmetatarsal amputations in patients with diabetes mellitus. Foot (Edinb). 2019 Apr 8;40:22-26. [Epub ahead of print] PMID: 31054475.
-
Holt, M. K., Pomeranz, L. E., Beier, K. T., Reimann, F., Gribble, F., & Rinaman, L. (2019). Synaptic Inputs to the Mouse Dorsal Vagal Complex and Its Resident Preproglucagon Neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience, 39 (49), 9767- 9781. PMID: 31666353. PMC6891065.
-
Jepsen SL, Grunddal KV, Wewer Albrechtsen NJ, Engelstoft MS, Gabe MBN, Jensen EP, Ørskov C, Poulsen SS, Rosenkilde MM, Pedersen J, Gribble FM, Reimann F, Deacon CF, Schwartz TW, Christ AD, Martin RE, Holst JJ. Paracrine Crosstalk between Intestinal L- and Dcells Controls Secretion of Glucagon-Like Peptide-1 in mice. Am J Physiol Endocrinol Metab. 2019 Sep 10. [Epub ahead of print] PMID: 31503512.
-
Jepsen SL, Vestergaard ET, Larraufie P, Gribble FM, Reimann F, Jørgensen JOL, Holst JJ, Kuhre RE. Ghrelin does not directly stimulate secretion of glucagon-like peptide-1. J Clin Endocrinol Metab. 2019 Oct 14. [Epub ahead of print] PMID: 31608930.
-
Jéru I, Vantyghem MC, Bismuth E, Cervera P, Barraud S; PLIN1-Study Group, Auclair M, Vatier C, Lascols O, Savage DB, Vigouroux C. Diagnostic Challenge in PLIN1-Associated Familial Partial Lipodystrophy. J Clin Endocrinol Metab. 2019 Dec 1;104(12):6025-6032. PubMed PMID: 31504636; PubMed Central PMCID: PMC6916795.
-
Johann K, Cremer AL, Fischer AW, Heine M, Pensado ER, Resch J, Nock S, Virtue S, Harder L, Oelkrug R, Astiz M, Brabant G, Warner A, Vidal-Puig A, Oster H, Boelen A, López M, Heeren J, Dalley JW, Backes H, Mittag J. Thyroid-Hormone-Induced Browning of White Adipose Tissue Does Not Contribute to Thermogenesis and Glucose Consumption. Cell Rep. 2019 Jun 11;27 (11):3385-3400.e3. PMID: 31189119.
-
Joustra SD, Roelfsema F, van Trotsenburg ASP, Schneider HJ, Kosilek RP, Kroon HM, Logan JG, Butterfield NC, Zhou X, Toufaily C, Bak B, Turgeon MO, Brûlé E, Steyn FJ, Gurnell M, Koulouri O, Le Tissier P, Fontanaud P, Duncan Bassett JH, Williams GR, Oostdijk W, Wit JM, Pereira AM, Biermasz NR, Bernard DJ, Schoenmakers N. IGSF1 Deficiency Results in Human and Murine Somatotrope Neurosecretory Hyperfunction. J Clin Endocrinol Metab. 2019 Oct 25. [Epub ahead of print] PMID: 31650157.
-
Karasik D, [5 authors], Barroso I, [148 authors], Ohlsson C. Disentangling the genetics of lean mass. Am J Clin Nutr. 2019 Feb 1;109(2):276-287. PMID: 30721968 PMCID: PMC6500901
-
Koulman A, Furse S, Baumert M, Goldberg G, Bluck L. Rapid profiling of triglycerides in human breast milk using liquid extraction surface analysis Fourier transform mass spectrometry reveals new very long chain fatty acids and differences within individuals. Rapid Commun Mass Spectrom. 2019 Aug 15;33(15):1267-1276. PMID:31009547; PubMed Central PMCID:PMC6772081
-
Kosīte D, König LM, De-Loyde K, Lee I, Pechey E, Clarke N, Maynard O, Morris RW, Munafò MR, Marteau TM, Fletcher PC, Hollands GJ. Plate size and food consumption: a pre-registered experimental study in a general population sample. Int J Behav Nutr Phys Act. 2019 Aug 28;16 (1):75. PMID: 31462252.
-
Kuhre RE, Ghiasi SM, Adriaenssens AE, Wewer Albrechtsen NJ, Andersen DB, Aivazidis A, Chen L, Mandrup-Poulsen T, Ørskov C, Gribble FM, Reimann F, Wierup N, Tyrberg B, Holst JJ. No direct effect of SGLT2 activity on glucagon secretion. Diabetologia. 2019 Jun;62 (6):1011-1023. 2019 Mar 22. PMID:30903205; PMCID: PMC7212061
-
Kuijper B, Hanson MA, Vitikainen EIK, Marshall HH, Ozanne SE, Cant MA. Developing differences: early-life effects and evolutionary medicine. Philos Trans R Soc Lond B Biol Sci. 2019 Apr 15;374(1770):20190039. PMID:30966882; PMCID:PMC6460072
-
Larraufie P, Roberts GP, McGavigan AK, Kay RG, Li J, Leiter A, Melvin A, Biggs EK, Ravn P, Davy K, Hornigold DC, Yeo GSH, Hardwick RH, Reimann F, Gribble FM. Important Role of the GLP-1 Axis for Glucose Homeostasis after Bariatric Surgery. Cell Rep. 2019 Feb 5;26(6):1399-1408.e6. PMID: 30726726 PMCID: PMC6367566
-
Lawton J, Blackburn M, Rankin D, Allen JM, Campbell FM, Leelarathna L, Tauschmann M, Thabit H, Wilinska ME, Elleri D, Hovorka R. Participants’ Experiences of, and Views About, Daytime Use of a Day-and -Night Hybrid Closed-Loop System in Real Life Settings: Longitudinal Qualitative Study. Diabetes Technol Ther. 2019 Mar;21(3):119-127. doi: 10.1089/dia.2018.0306. Epub 2019 Feb 5. PMID: 30720338 PMCID: PMC6434584
-
Lee E, Miedzybrodzka EL, Zhang X, Hatano R, Miyamoto J, Kimura I, Fujimoto K, Uematsu S, Rodriguez-Cuenca S, Vidal-Puig A, Gribble FM, Reimann F, Miki T. Diet-Induced Obese Mice and Leptin-Deficient Lepob/ob Mice Exhibit Increased Circulating GIP Levels Produced by Different Mechanisms. Int J Mol Sci. 2019 Sep 10;20(18). PMID: 31509948.
-
Leelarathna L, Beck RW, Bergenstal RM, Thabit H, Hovorka R; APCam11, AP@home04, and APCam08 Investigators. Glucose Management Indicator (GMI): Insights and Validation Using Guardian 3 and Navigator 2 Sensor Data. Diabetes Care. 2019 Apr;42(4):e60-e61. doi: 10.2337/dc18-2479. Epub 2019 Feb 6. PMID: 30728221
-
Lippincott MF, León S, Chan YM, Fergani C, Talbi R, Farooqi IS, Jones CM, Arlt W, Stewart SE, Cole TR, Terasawa E, Hall JE, Shaw ND, Navarro VM, Seminara SB. Hypothalamic Reproductive Endocrine Pulse Generator Activity Independent of Neurokinin B and Dynorphin Signaling. J Clin Endocrinol Metab. 2019 May 27. [Epub ahead of print]. PMID:31132118; PMCID:PMC6736049
-
López-Tello J, Pérez-García V, Khaira J, Kusinski LC, Cooper WN, Andreani A, Grant I, Fernández de Liger E, Lam BY, Hemberger M, Sandovici I, Constancia M, Sferruzzi-Perri AN. Fetal and trophoblast PI3K p110α have distinct roles in regulating resource supply to the growing fetus in mice. Elife. 2019 Jun 26;8. PMID:31241463; PMCID: PMC6634971
-
Lotta LA, Mokrosiński J, Mendes de Oliveira E, Li C, Sharp SJ, Luan J, Brouwers B, Ayinampudi V, Bowker N, Kerrison N, Kaimakis V, Hoult D, Stewart ID, Wheeler E, Day FR, Perry JRB, Langenberg C, Wareham NJ, Farooqi IS. Human Gain-of-Function MC4R Variants Show Signaling Bias and Protect against Obesity. Cell. 2019 Apr 18;177(3):597-607.e9. PMID:31002796; PMCID: PMC6476272
-
Lu VB, Rievaj J, O’Flaherty EA, Smith CA, Pais R, Pattison LA, Tolhurst G, Leiter AB, Bulmer DC, Gribble FM, Reimann F. Adenosine triphosphate is co-secreted with glucagon-like peptide-1 to modulate intestinal enterocytes and afferent neurons. Nat Commun. 2019 Mar 4;10(1):1029. doi: 10.1038/s41467-019-09045-9. PMID: 30833673 PMCID: PMC6399286
-
Macaulay S, Buchmann EJ, Dunger DB, Norris SA. Reliability and validity of last menstrual period for gestational age estimation in a low-to-middle-income setting. J Obstet Gynaecol Res. 2019 Jan;45(1):217-225. doi: 10.1111/jog.13801. Epub 2018 Sep 6. PMID: 30191629
-
Maniero C, Scudieri P, Haris Shaikh L, Zhao W, Gurnell M, Galietta LJV, Brown MJ. ANO4 (Anoctamin 4) Is a Novel Marker of Zona Glomerulosa That Regulates Stimulated Aldosterone Secretion. Hypertension. 2019 Nov;74(5):1152-1159. PMID: 31564164.
-
Mann JP, Savage DB. What lipodystrophies teach us about the metabolic syndrome. J Clin Invest. 2019 Aug 5;130:4009-4021. Review. PMID: 31380809.
-
Marcovecchio ML, Dalton RN, Daneman D, Deanfield J, Jones TW, Neil HAW, Dunger DB; Adolescent type 1 Diabetes cardio-renal Intervention Trial (AdDIT) study group. A new strategy for vascular complications in young people with type 1 diabetes mellitus. Nat Rev Endocrinol. 2019 Jul;15(7):429-435. Review. PMID:30996294
-
Mazarello Paes V, Barrett JK, Taylor-Robinson DC, Chesters H, Charalampopoulos D, Dunger DB, Viner RM, Stephenson TJ. Effect of early glycemic control on HbA1c tracking and development of vascular complications after 5 years of childhood onset type 1 diabetes: Systematic review and meta -analysis. Pediatr Diabetes. 2019 Aug;20(5):494-509. Epub 2019 Apr 24. Review. PMID:30932298; PMCID:PMC6701989
-
Medic N, Kochunov P, Ziauddeen H, Ersche KD, Nathan PJ, Ronan L, Fletcher PC. BMI-related cortical morphometry changes are associated with altered white matter structure. Int J Obes (Lond). 2019 Mar;43(3):523-532. PMID: 30568264 PMCID: PMC6462878
-
Melvin A, Lacerda E, Dockrell S M, O’Rahilly S, Nacul L. Circulating levels of GDF15 in patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. J Transl Med. 2019 Dec 4;17 (1):409. PMID: 31801546. PMCID: PMC6892232
-
Melvin A, Stears A, Savage DB. Recent developments in lipodystrophy. Curr Opin Lipidol. 2019 Aug;30(4):284-290. PMID: 31135595.
-
Menting MD, Mintjens S, van de Beek C, Frick CJ, Ozanne SE, Limpens J, Roseboom TJ, Hooijmans CR, van Deutekom AW, Painter RC. Maternal obesity in pregnancy impacts offspring cardiometabolic health: Systematic review and meta-analysis of animal studies. Obes Rev. 2019 May;20(5):675-685. doi: 10.1111/obr.12817. PMID: 30633422 PMCID: PMC6849816
-
Menzies-Gow A, Corren J, Bel EH, Maspero J, Heaney LG, Gurnell M, Wessman P, Martin UJ, Siddiqui S, Garcia Gil E. Corticosteroid tapering with benralizumab treatment for eosinophilic asthma: PONENTE Trial. ERJ Open Res. 2019 Sep 25;5(3). PMID: 31579676.
-
Müller TD, Finan B, Bloom SR, D’Alessio D, Drucker DJ, Flatt PR, Fritsche A, Gribble F, Grill HJ, Habener JF, Holst JJ, Langhans W, Meier JJ, Nauck MA, Perez-Tilve D, Pocai A, Reimann F, Sandoval DA, Schwartz TW, Seeley RJ, Stemmer K, Tang-Christensen M, Woods SC, DiMarchi RD, Tschöp MH. Glucagon-like peptide 1 (GLP-1). Mol Metab. 2019 Dec;30:72-130. Epub 2019 Sep 30. Review. PMID: 31767182. PMCID: PMC6812410.
-
Musial B, Fernandez-Twinn DS, Duque-Guimaraes D, Carr SK, Fowden AL, Ozanne SE, Sferruzzi-Perri AN. Exercise alters the molecular pathways of insulin signaling and lipid handling in maternal tissues of obese pregnant mice. Physiol Rep. 2019 Aug;7(16). PMID: 31466137.
-
Musolino G, Allen JM, Hartnell S, Wilinska ME, Tauschmann M, Boughton C, Campbell F, Denvir L, Trevelyan N, Wadwa P, DiMeglio L, Buckingham BA, Weinzimer S, Acerini CL, Hood K, Fox S, Kollman C, Sibayan J, Borgman S, Cheng P, Hovorka R. Assessing the efficacy, safety and utility of 6-month day-and-night automated closed-loop insulin delivery under free-living conditions compared with insulin pump therapy in children and adolescents with type 1 diabetes: an open-label, multicentre, multinational, single-period, randomised, parallel group study protocol. BMJ Open. 2019 Jun 3;9(6):e027856. PMID:31164368; PMCID: PMC6561428
-
Musolino G, Dovc K, Boughton CK, Tauschmann M, Allen JM, Nagl K, Fritsch M, Yong J, Metcalfe E, Schaeffer D, Fichelle M, Schierloh U, Thiele AG, Abt D, Kojzar H, Mader JK, Slegtenhorst S, Ashcroft N, Wilinska ME, Sibayan J, Cohen N, Kollman C, Hofer SE, Fröhlich -Reiterer E, Kapellen TM, Acerini CL, de Beaufort C, Campbell F, Rami-Merhar B, Hovorka R; Kidsap Consortium. Reduced burden of diabetes and improved quality of life: Experiences from unrestricted day-and-night hybrid closed-loop use in very young children with type 1 diabetes. Pediatr Diabetes. 2019 May 29. [Epub ahead of print] PMID:31140654; PMCID:PMC6771658
-
Nicholas LM, Ozanne SE. Early life programming in mice by maternal overnutrition: mechanistic insights and interventional approaches. Philos Trans R Soc Lond B Biol Sci. 2019 Apr 15;374(1770):20180116. PMID:30966886; PMCID:PMC6460073
-
Nyimanu D, Kay RG, Sulentic P, Kuc RE, Ambery P, Jermutus L, Reimann F, Gribble FM, Cheriyan J, Maguire JJ, Davenport AP. Development and validation of an LC-MS/MS method for detection and quantification of in vivo derived metabolites of [Pyr(1)]apelin-13 in humans. Sci Rep. 2019 Dec 27;9(1):19934. PubMed PMID: 31882594; PubMed Central PMCID:PMC6934825.
-
Oral EA, Gorden P, Cochran E, Araújo-Vilar D, Savage DB, Long A, Fine G, Salinardi T, Brown RJ. Long -term effectiveness and safety of metreleptin in the treatment of patients with partial lipodystrophy. Endocrine. 2019 Jun;64(3):500-511. doi: 10.1007/s12020-019-01862-8. PMID: 30805888 PMCID: PMC7340120
-
Ortega FJ, Moreno-Navarrete JM, Mercader JM, Gómez-Serrano M, García-Santos E, Latorre J, Lluch A, Sabater M, Caballano-Infantes E, Guzmán R, Macías-González M, Buxo M, Gironés J, Vilallonga R, Naon D, Botas P, Delgado E, Corella D, Burcelin R, Frühbeck G, Ricart W, Simó R, Castrillon-Rodríguez I, Tinahones FJ, Bosch F, Vidal-Puig A, Malagón MM, Peral B, Zorzano A, Fernández-Real JM. Cytoskeletal transgelin 2 contributes to gender-dependent adipose tissue expandability and immune function. FASEB J. 2019 Aug;33(8):9656-9671. PMID: 31145872.
-
O’Shea PM, O’Donoghue D, Bashari W, Senanayake R, Joyce MB, Powlson AS, Browne D, O’Sullivan GJ, Cheow H, Mendichovszky I, Quill D, Lowery A, Lappin D, Gurnell M, Dennedy MC. 11 C-Metomidate PET/CT is a useful adjunct for lateralization of primary aldosteronism in routine clinical practice. Clin Endocrinol (Oxf). 2019 May;90(5):670-679. doi: 10.1111/cen.13942. Epub 2019 Mar 18. PMID: 30721535
-
Parkinson JRC, Emsley R, Adkins JLT, Longford N, Ozanne SE, Holmes E, Modi N. Clinical and molecular evidence of accelerated ageing following very preterm birth. Pediatr Res. 2019 Dec 7. Epub ahead of print. PMID: 31812156.
-
Patel S, Alvarez-Guaita A, Melvin A, Rimmington D, Dattilo A, Miedzybrodzka EL, Cimino I, Maurin AC, Roberts GP, Meek CL, Virtue S, Sparks LM, Parsons SA, Redman LM, Bray GA, Liou AP, Woods RM, Parry SA, Jeppesen PB, Kolnes AJ, Harding HP, Ron D, Vidal-Puig A, Reimann F, Gribble FM, Hulston CJ, Farooqi IS, Fafournoux P, Smith SR, Jensen J, Breen D, Wu Z, Zhang BB, Coll AP, Savage DB, O’Rahilly S. GDF15 Provides an Endocrine Signal of Nutritional Stress in Mice and Humans. Cell Metab. 2019 Mar 5;29(3):707-718.e8. PMID: 30639358 PMCID: PMC6408327
-
Patel V, Bidault G, Chambers JE, Carobbio S, Everden AJT, Garcés C, Dalton LE, Gribble FM, VidalPuig A, Marciniak SJ. Inactivation of Ppp1r15a minimises weight gain and insulin resistance during caloric excess in female mice. Sci Rep. 2019 Feb 27;9(1):2903. doi: 10.1038/s41598-019-39562-y. PMID: 30814564 PMCID: PMC6393541
-
Peters C, Nicholas AK, Schoenmakers E, Lyons G, Langham S, Serra EG, Sebire NJ, Muzza M, Fugazzola L, Schoenmakers N. DUOX2/DUOXA2 Mutations Frequently Cause Congenital Hypothyroidism that Evades Detection on Newborn Screening in the United Kingdom. Thyroid. 2019 Jun;29(6):790-801. PMID:31044655; PMCID:PMC6588112
-
Petkevicius K, Virtue S, Bidault G, Jenkins B, Çubuk C, Morgantini C, Aouadi M, Dopazo J, Serlie MJ, Koulman A, Vidal-Puig A. Accelerated phosphatidylcholine turnover in macrophages promotes adipose tissue inflammation in obesity. Elife. 2019 Aug 16;8. PMID: 31418690.
-
Petry CJ, Ong KK, Hughes IA, Acerini CL, Dunger DB. Age at Menarche and Blood Pressure in Pregnancy. Pregnancy Hypertens. 2019 Jan;15:134-140. PMID: 30713829 PMCID: PMC6352955
-
Prats-Puig A, Xargay-Torrent S, Carreras-Badosa G, Mas-Parés B, Bassols J, Petry CJ, Girardot M, D E Zegher F, Ibáñez L, Dunger DB, Feil R, López-Bermejo A. Methylation of the C19MC microRNA locus in the placenta: association with maternal and chilhood body size. Int J Obes (Lond). 2019 Sep 25. [Epub ahead of print] PMID: 31554916.
-
Prentice PM, Olga L, Petry CJ, Simmons D, Murphy HR, Hughes IA, Acerini CL, Ong KK, Dunger DB. Reduced size at birth and persisting reductions in adiposity in recent, compared with earlier, cohorts of infants born to mothers with gestational diabetes mellitus. Diabetologia. 2019 Nov;62(11):1977-1987. Epub 2019 Aug 9. PubMed PMID: 31396660; PubMed Central PMCID: 6805804.
-
Prentice PM, Schoemaker MH, Vervoort J, Hettinga K, Lambers TT, van Tol EAF, Acerini CL, Olga L, Petry CJ, Hughes IA, Koulman A, Ong KK, Dunger DB. Human Milk Short-Chain Fatty Acid Composition is Associated with Adiposity Outcomes in Infants. J Nutr. 2019 May 1;149(5):716-722. PMID:31050748
-
Rana BMJ, Jou E, Barlow JL, Rodriguez-Rodriguez N, Walker JA, Knox C, Jolin HE, Hardman CS, Sivasubramaniam M, Szeto A, Cohen ES, Scott IC, Sleeman MA, Chidomere CI, Cruz Migoni S, Caamano J, Jorgensen HF, Carobbio S, Vidal-Puig A, McKenzie ANJ. A stromal cell niche sustains ILC2-mediated type-2 conditioning in adipose tissue. J Exp Med. 2019 Sep 2;216 (9):1999-2009. PMID: 31248899.
-
Razolli D, de Araújo T, Sant’Ana M, Kirwan P, Cintra D, Merkle F, Velloso L. POMC processing in the hypothalamus is directly regulated by saturated fat – implications for the development of obesity. Neuroendocrinology. 2019 May 20. [Epub ahead of print]. PMID: 31104058
-
Reimann F; Diakogiannaki E; Moss C E; Gribble F M. Cellular mechanisms governing Glucosedependent insulinotropic polypeptide secretion. Peptides. 2020 Mar;125:170206 170206. Epub 2019 Nov 19. Review. PubMed PMID: 31756367.
-
Riveros-McKay F, Mistry V, Bounds R, Hendricks A, Keogh JM, Thomas H, Henning E, Corbin LJ; Understanding Society Scientific Group, O’Rahilly S, Zeggini E, Wheeler E, Barroso I, Farooqi IS. Genetic architecture of human thinness compared to severe obesity. PLoS Genet. 2019 Jan 24;15(1):e1007603. PMID: 30677029 PMCID: PMC6345421
-
Roberts GP, Larraufie P, Richards P, Kay RG, Galvin SG, Miedzybrodzka EL, Leiter A, Li HJ, Glass LL, Ma MKL, Lam B, Yeo GSH, Scharfmann R, Chiarugi D, Hardwick RH, Reimann F, Gribble FM. Comparison of Human and Murine Enteroendocrine Cells by Transcriptomic and Peptidomic Profiling. Diabetes. 2019 May;68(5):1062-1072. doi: 10.2337/db18-0883. Epub 2019 Feb 7. PMID: 30733330
-
Rodriguez-Cuenca S, Carobbio S, Barceló-Coblijn G, Prieur X, Relat J, Amat R, Campbell M, Dias AR, Bahri M, Gray SL, Vidal-Puig A. P465L-PPARγ mutation confers partial resistance to the hypolipidaemic action of fibrates. Diabetes Obes Metab. 2018 Oct;20(10):2339-2350. doi: 10.1111/dom.13370. PMID:29790245 PMCID:PMC6589924
-
Ronan L, Alexander-Bloch A, Fletcher PC. Childhood Obesity, Cortical Structure, and Executive Function in Healthy Children. Cereb Cortex. 2019 Oct 24. [Epub ahead of print] PMID: 31646343.
-
Ruan Y, Willemsen RH, Wilinska ME, Tauschmann M, Dunger DB, Hovorka R. Mixed-meal tolerance test to assess residual beta-cell secretion: Beyond the area-under-curve of plasma C-peptide concentration. Pediatr Diabetes. 2019 May;20(3):282-285. doi: 10.1111/pedi.12816. PMID: 30652426 PMCID: PMC6487945
-
Savage DB, Watson L, Carr K, Adams C, Brage S, Chatterjee KK, Hodson L, Boesch C, Kemp GJ, Sleigh A. Accumulation of saturated intramyocellular lipid is associated with insulin resistance. J. Lipid Res. (2019) Jul;60(7):1323-1332. Epub 2019 May 2. PMID:31048405; PMCID:PMC6602127
-
Sefton C, Davies A, Allen TJ, Wray JR, Shoop R, Adamson A, Humphreys N, Coll AP, White A, Harno E. The metabolic abnormalities of chronic high dose glucocorticoids are not mediated by hypothalamic AgRP in male mice. Endocrinology. 2019 May 1;160(5):964-978. doi: 10.1210/en.2019-00018. PMID: 30794724 PMCID: PMC6444294
-
Schierloh U, Wilinska ME, Pit-Ten Cate IM, Baumann P, Hovorka R, De Beaufort C; Spidiman Study Group: Single Port Insulin Infusion for Improved Diabetes Management. Lower plasma insulin levels during overnight closed-loop in school children with type 1 diabetes: Potential advantage? A randomized cross-over trial. PLoS One. 2019 Mar 8;14(3):e0212013. doi: 10.1371/journal.pone.0212013. eCollection 2019. PMID: 30849076 PMCID: PMC6408001
-
Speight J, Holmes-Truscott E, Little SA, Leelarathna L, Walkinshaw E, Tan HK, Bowes A, Kerr D, Flanagan D, Heller SR, Evans ML, Shaw JAM. Satisfaction with the Use of Different Technologies for Insulin Delivery and Glucose Monitoring Among Adults with Long-Standing Type 1 Diabetes and Problematic Hypoglycemia: 2-Year Follow-Up in the HypoCOMPaSS Randomized Clinical Trial. Diabetes Technol Ther. 2019 Nov;21(11):619-626. PMID: 31335201.
-
Sutherland MJ, Camm EJ, Giussani DA, Ozanne SE. Chronic gestational hypoxia accelerates ovarian aging and lowers ovarian reserve in next-generation adult rats. FASEB J. 2019 Jun;33 (6):7758-7766. Epub 2019 Mar 19. PMID:30888848; PMCID:PMC6529349
-
Tarry-Adkins JL, Aiken CE, Ozanne SE. Neonatal, infant, and childhood growth following metformin versus insulin treatment for gestational diabetes: A systematic review and meta-analysis. PLoS Med. 2019 Aug 6;16(8):e1002848. PMID: 31386659.
-
Tarry-Adkins JL, Ozanne SE. Poor Early Growth and Age-Associated Disease. Subcell Biochem. 2019;91:1-19. PMID: 30888647
-
Tauschmann M, Allen JM, Nagl K, Fritsch M, Yong J, Metcalfe E, Schaeffer D, Fichelle M, Schierloh U, Thiele AG, Abt D, Kojzar H, Mader JK, Slegtenhorst S, Barber N, Wilinska ME, Boughton C, Musolino G, Sibayan J, Cohen N, Kollman C, Hofer SE, Fröhlich-Reiterer E, Kapellen TM, Acerini CL, de Beaufort C, Campbell F, Rami-Merhar B, Hovorka R; KidsAP Consortium. Home Use of Day-and-Night Hybrid Closed-Loop Insulin Delivery in Very Young Children: A Multicenter, 3-Week, Randomized Trial. Diabetes Care. 2019 Apr;42(4):594-600. doi: 10.2337/dc18-1881. Epub 2019 Jan 28. PMID: 30692242
-
Teulings NEWD, Masconi KL, Ozanne SE, Aiken CE, Wood AM. Effect of interpregnancy weight change on perinatal outcomes: systematic review and meta-analysis. BMC Pregnancy Childbirth. 2019 Oct 28;19(1):386. PMID: 31660893.
-
Thakar R, Gajewska-Knapik G, Ogilvy-Stuart AL, Chatterjee K, Moran C. Response to Letter to the Editor: “Alemtuzumab-induced thyroid dysfunction exhibits distinctive clinical and immunological features”. J.Clin. Endocrinol. Metab. (2019). PMID:30977836
-
Tschaikner M, Powell K, Jungklaus M, Fritz M, Ellmerer M, Hovorka R, Lane S, Pieber TR, Regittnig W. Novel Single-Site Device for Conjoined Glucose Sensing and Insulin Infusion: Performance Evaluation in Diabetes Patients During Home-Use. IEEE Trans Biomed Eng. 2019 Jun 27. [Epub ahead of print]. PMID:31251175
-
Turcot V, 39 authors, Barroso I, 65 authors, Farooqi IS, 293 authors, Loos RJF. Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity. Nat Genet. 2019 Jul;51(7):1191- 1192. PMID:31160809
-
van der Klaauw AA, Croizier S, Mendes de Oliveira E, Stadler LKJ, Park S, Kong Y, Banton MC, Tandon P, Hendricks AE, Keogh JM, Riley SE, Papadia S, Henning E, Bounds R, Bochukova EG, Mistry V, O’Rahilly S, Simerly RB; INTERVAL; UK10K Consortium, Minchin JEN, Barroso I, Jones EY, Bouret SG, Farooqi IS. Human Semaphorin 3 Variants Link Melanocortin Circuit Development and Energy Balance. Cell. 2019 Feb 7;176(4):729-742.e18. PMID: 30661757 PMCID: PMC6370916
-
Vargas-Castillo A, Tobon-Cornejo S, Del Valle-Mondragon L, Torre-Villalvazo I, SchcolnikCabrera A, Guevara-Cruz M, Pichardo-Ontiveros E, Fuentes-Romero R,Bader M, Alenina N, Vidal-Puig A, Hong E, Torres N, Tovar AR. Angiotensin-(1-7) induces beige fat thermogenesis through the Mas receptor. Metabolism. 2019 Dec 13;103:154048. Epub ahead of print. PubMed PMID: 31843339. PMCID: PMC7054746.
-
Vasiljevic M, Fuller G, Pilling M, Hollands GJ, Pechey R, Jebb SA, Marteau TM. What is the impact of increasing the prominence of calorie labelling? A stepped wedge randomised controlled pilot trial in worksite cafeterias. Appetite. 2019 Oct 1;141:104304. Epub 2019 May 29. PMID:31152762
-
Vergari E, Knudsen JG, Ramracheya R, Salehi A, Zhang Q, Adam J, Asterholm IW, Benrick A, Briant LJB, Chibalina MV, Gribble FM, Hamilton A, Hastoy B, Reimann F, Rorsman NJG, Spiliotis II, Tarasov A, Wu Y, Ashcroft FM, Rorsman P. Insulin inhibits glucagon release by SGLT2-induced stimulation of somatostatin secretion. Nat Commun. 2019 Jan 11;10(1):139. PMID: 30635569 PMCID: PMC6329806
-
Vestergaard ET, Hjelholt AJ, Kuhre RE, Møller N, Larraufie P, Gribble FM, Reimann F, Jessen N, Holst JJ, Jørgensen JOL. Acipimox Acutely Increases GLP-1 Concentrations in Overweight Subjects and Hypopituitary Patients. J Clin Endocrinol Metab. 2019 Jul 1;104(7):2581- 2592. PMID:30726969; PMCID:PMC7212086
-
Wallenius V, Elias E, Elebring E, et al. Suppression of enteroendocrine cell glucagon-like peptide (GLP)-1 release by fat-induced small intestinal ketogenesis: a mechanism targeted by Roux-enY gastric bypass surgery but not by preoperative very-low-calorie diet. Gut Published Online First: 21 November 2019. doi: 10.1136/gutjnl-2019-319372. PMID: 31753852.
-
Watson LPE, Carr KS, Venables MC, Acerini CL, Lyons G, Moran C, Murgatroyd PR, Chatterjee K. Quantifying energy expenditure in childhood: utility in managing pediatric metabolic disorders. Am J Clin Nutr. 2019 Nov 1;110(5):1186-1191. PMID: 31410443. PMCID: PMC6821543.
-
Wejaphikul K, Groeneweg S, Hilhorst-Hofstee Y, Chatterjee VK, Peeters RP, Meima ME, Visser WE. Insight into molecular determinants of T3 vs. T4 recognition from mutations in thyroid hormone receptor alpha and beta. J.Clin. Endocrinol. Metab. (2019). PMID:30817817; PMCID:PMC6599431
-
Westwater ML, Vilar-López R, Ziauddeen H, Verdejo-García A, Fletcher PC. Combined effects of age and BMI are related to altered cortical thickness in adolescence and adulthood. Dev Cogn Neurosci. 2019 Dec;40:100728. Epub 2019 Nov 5. PubMed PMID: 31751856; PubMed Central PMCID: PMC6913515.
-
Wieczorek A, Perani CV, Nixon M, Constancia M, Sandovici I, Zazara DE, Leone G, Zhang MZ, Arck PC, Solano ME. Sex-specific regulation of stress-induced fetal glucocorticoid surge by the mouse placenta. Am J Physiol Endocrinol Metab. 2019 Jul 1;317(1):E109-E120. Epub 2019 Apr 16. PMID:30990748
-
Wray JR, Davies A, Sefton C, Allen TJ, Adamson A, Chapman P, Lam BYH, Yeo GSH, Coll AP, Harno E, White A. Global transcriptomic analysis of the arcuate nucleus following chronic glucocorticoid treatment. Mol Metab. 2019 Aug;26:5-17. PubMed PMID: 31176677.
-
Yang Y, van der Klaauw AA, Zhu L, Cacciottolo TM, He Y, Stadler LKJ, Wang C, Xu P, Saito K, Hinton A Jr, Yan X, Keogh JM, Henning E, Banton MC, Hendricks AE, Bochukova EG, Mistry V, Lawler KL, Liao L, Xu J, O’Rahilly S, Tong Q; UK10K Consortium, Inês Barroso, O’Malley BW, Farooqi IS, Xu Y. Steroid receptor coactivator-1 modulates the function of Pomc neurons and energy homeostasis. Nat Commun. 2019 Apr 12;10(1):1718. PMID:30979869; PMCID:PMC6461669
-
Yeo SH, Kyle V, Blouet C, Jones S, Colledge WH. Mapping neuronal inputs to Kiss1 neurons in the arcuate nucleus of the mouse. PLoS One. 2019 Mar 27;14(3):e0213927. eCollection 2019. PMID:30917148; PMCID:PMC6436706
-
Ziegler AN, Feng Q, Chidambaram S, Testai JM, Kumari E, Rothbard DE, Constancia M, Sandovici I, Cominski T, Pang K, Gao N, Wood TL, Levison SW. Insulin-like Growth Factor II: An Essential Adult Stem Cell Niche Constituent in Brain and Intestine. Stem Cell Reports. 2019 Apr 9;12(4):816-830. doi: 10.1016/j.stemcr.2019.02.011. PMID: 30905741 PMCID: PMC6450461
2018
- Adriaenssens AE, Reimann F, Gribble FM.Distribution and Stimulus Secretion Coupling of En- teroendocrine Cells along the Intestinal Tract. Compr Physiol. 2018 Sep 14;8(4):1603-1638.
- Agostini M*, Schoenmakers E*, Beig J, Fairall L, Szatmari I, Rajanayagam O, Muskett FW, Adams C, Marais AD, O’Rahilly S, Semple RK, Nagy L, Majithia A, Schwabe JWR, Blom DJ, Murphy R, Chatterjee K†, Savage DB†. A Pharmacogenetic Approach to the Treatment of Patients With PPARG Mutations. Diabetes (2018) 67: 1086-1092 (*coequal first authors;†joint senior authors). PMID:29622583 PMCID:PMC5967605
- Aprile M, Cataldi S, Ambrosio MR, D’Esposito V, Lim K, Dietrich A, Blüher M, Savage DB, Formisano P, Ciccodicola A, Costa V. PPARγΔ5, a Naturally Occurring Dominant-Negative Splice Isoform, Impairs PPARγ Function and Adipocyte Differentiation. Cell Rep. 2018 Nov 6;25 (6):1577-1592.e6. doi: 10.1016/j.celrep.2018.10.035.PMID:30404011
- Bally L, Thabit H, Hovorka R. Closed-Loop Insulin for Glycemic Control in Noncritical Care. N Engl J Med. 2018 Nov 15;379(20):1970-1971. doi: 10.1056/NEJMc1811995. No abstract availa- ble. PMID:30428293
- Bauzá-Thorbrügge M, Rodríguez-Cuenca S, Vidal-Puig A, Galmés-Pascual BM, Sbert-Roig M, Gianotti M, Lladó I, Proenza AM J. GPER and ERα mediate estradiol enhancement of mitochon- drial function in inflamed adipocytes through a PKA dependent mechanism. Steroid Biochem Mol Biol. 2018 Sep 22. pii: S0960-0760(18)30068-2. PMID:30253224
- Beeson JH, Blackmore HL, Carr SK, Dearden L, Duque-Guimarães DE, Kusinski LC, Pantaleão LC, Pinnock AG, Aiken CE, Giussani DA, Fernandez-Twinn DS, Ozanne SE. Maternal exercise intervention in obese pregnancy improves the cardiovascular health of the adult male offspring. Mol Metab. 2018 Oct;16:35-44. PMID: 30293577.PMCID: PMC6157615
- Berends LM, Dearden L, Tung YCL, Voshol P, Fernandez-Twinn DS, Ozanne SE. Programming of central and peripheral insulin resistance by low birthweight and postnatal catch-up growth in male mice. Diabetologia. 2018 Oct;61(10):2225-2234. PMID: 30043179PMCID: PMC6133152
- Billing LJ, Smith CA, Larraufie P, Goldspink DA, Galvin S, Kay RG, Howe JD, Walker R, Pruna M, Glass L, Pais R, Gribble FM, Reimann F.Co-storage and release of insulin-like peptide-5, glu- cagon-like peptide-1 and peptideYY from murine and human colonic enteroendocrine cells. Mol Metab. 2018 Oct;16:65-75. PMID: 30104166 PMCID: PMC6158034
- Boughton CK, Hovorka R. Is an artificial pancreas (closed-loop system) for Type 1 diabetes ef- fective? Diabet Med. 2018 Sep 5. Review. PMID: 30183096
- Chase JG, Desaive T, Bohe J, Cnop M, De Block C, Gunst J, Hovorka R, Kalfon P, Krinsley J, Renard E, Preiser JC. Improving glycemic control in critically ill patients: personalized care to mimic the endocrine pancreas. Crit Care. 2018 Aug 2;22(1):182. Review. PMID: 30071851 PMCID: PMC6091026
- Church D, Cardoso L, Kay RG, Williams CL, Freudenthal B, Clarke C, Harris J, Moorthy M, Kar- ra E, Gribble FM, Reimann F, Burling K, Williams AJK, Munir A, Jones TH, Führer D, Moeller LC, Cohen M, Khoo B, Halsall D, Semple RK. Assessment and Management of Anti-Insulin Auto- antibodies in Varying Presentations of Insulin Autoimmune Syndrome. J Clin Endocrinol Metab. 2018 Oct 1;103(10):3845-3855. PMID: 30085133 PMCID: PMC6179165
- Farrington C, Stewart Z, Hovorka R, Murphy HJ. Women’s Experiences of Day-and-Night Closed-Loop Insulin Delivery During Type 1 Diabetes Pregnancy. Diabetes Sci Technol. 2018 Oct 5:1932296818800065. PMID: 30288999PMCID: PMC6232744
- Goldspink DA, Reimann F, Gribble FM. Models and Tools for Studying Enteroendocrine Cells. Endocrinology. 2018 Sep 14. doi: 10.1210/en.2018-00672. PMID:30239642
- Harno E, Gali Ramamoorthy T, Coll AP, White A.POMC: The Physiological Power of Hormone Processing. Physiol Rev. 2018 Oct 1;98(4):2381-2430. PMID: 30156493PMCID: PMC6170974
- Hendricks AE, Billups SC, Pike HNC, Farooqi IS, Zeggini E, Santorico SA, Barroso I, Dupuis J. ProxECAT: Proxy External Controls Association Test. A new case-control gene region associ- ation test using allele frequencies from public controls. PLoS Genet. 2018 Oct 16;14 (10):e1007591. PMID: 30325923PMCID: PMC6191077
- Holt MK, Richards JE, Cook DR, Brierley DI, Williams DL, Reimann F, Gribble FM, Trapp S. Preproglucagon Neurons in the Nucleus of the Solitary Tract are the Main Source of Brain GLP-1, Mediate Stress-Induced Hypophagia, and Limit Unusually Large Intakes of Food. Diabe- tes. 2018 Oct 2. pii: db180729. PMID: 30279161PMCID: PMC6314470
- Jenkins B, Aoun M, Feillet-Coudray C, Coudray C, Ronis M, Koulman A. The Dietary Total-Fat Content Affects the In Vivo Circulating C15:0 and C17:0 Fatty Acid Levels Independently. Nutri- ents. 2018 Nov 3;10(11). pii: E1646. doi: 10.3390/nu10111646.PMID:30400275
- Kirwan P, Kay RG, Brouwers B, Herranz-Pérez V, Jura M, Larraufie P, Jerber J, Pembroke J, Bartels T, White A, Gribble FM, Reimann F, Farooqi IS, O’Rahilly S, Merkle FT. Quantitative mass spectrometry for human melanocortin peptides in vitro and in vivo suggests prominent roles for β-MSH and desacetyl α-MSH in energy homeostasis. Mol Metab. 2018 Nov;17:82-97. PMID: 30201275 PMCID: PMC6197775
- Klonoff DC, Evans ML, Lane W, Kempe HP, Renard E, Hans DeVries J, Graungaard T, Hyseni A, Gondolf T, Battelino T. A randomized, multicentre trial evaluating the efficacy and safety of fast-acting insulin aspart in continuous subcutaneous insulin infusion in adults with type 1 diabe- tes (onset 5). Diabetes Obes Metab. 2018 Dec 9. doi: 10.1111/dom.13610. PMID:30537180
- Lawton J, Blackburn M, Rankin D, Allen J, Campbell F, Leelarathna L, Tauschmann M, Thabit H, Wilinska ME, Hovorka R; APCam11 Consortium. The impact of using a closed-loop system on food choices and eating practices among people with Type 1 diabetes: a qualitative study involving adults, teenagers and parents. Diabet Med. 2018 Dec 21. doi: 10.1111/dme.13887. PMID: 30575114PMCID: PMC6510609
- Lotta LA, Stewart ID, Sharp SJ, Day FR, Burgess S, Luan J, Bowker N, Cai L, Li C, Wittemans LBL, Kerrison ND, Khaw KT, McCarthy MI, O’Rahilly S, Scott RA, Savage DB, Perry JRB, Langenberg C, Wareham NJ. Association of Genetically Enhanced Lipoprotein Lipase-Mediated Lipolysis and Low-Density Lipoprotein Cholesterol-Lowering Alleles With Risk of Coronary Dis- ease and Type 2 Diabetes. JAMA Cardiol. 2018 Oct 1;3(10):957-966. PMID: 30326043PMCID: PMC6217943
- Mann JP, Vreugdenhil A, Socha P, Jańczyk W, Baumann U, Rajwal S, Casswall T, Marcus C, van Mourik I, O’Rahilly S, Savage DB, Noble-Jamieson G, Lacaille F, Dabbas M, Dubern B, Kelly DA, Nobili V, Anstee European paediatric non-alcoholic fatty liver disease registry (EU- PNAFLD): Design and rationale. Contemp Clin Trials. 2018 Dec;75:67-71. doi: 10.1016/ j.cct.2018.11.003. Epub 2018 Nov 5. PMID30408605
- Martin-Gallausiaux C, Larraufie P, Jarry A, Béguet-Crespel F, Marinelli L, Ledue F, Reimann F, Blottière HM, Lapaque N.Butyrate Produced by Commensal Bacteria Down-Regulates Indola- mine 2,3-Dioxygenase 1 (IDO-1) Expression via a Dual Mechanism in Human Intestinal Epitheli- al Cells. Front Immunol. 2018 Dec 11;9:2838. doi: 10.3389/fimmu.2018.02838. eCollection 2018.PMID:30619249 PMCID: PMC6297836
- Menting MD, van de Beek C, Mintjens S, Wever KE, Korosi A, Ozanne SE, Limpens J, Rose- boom TJ, Hooijmans C, Painter RC. The link between maternal obesity and offspring neurobe- havior: a systematic review of animal experiments. Neurosci Biobehav Rev. 2019 Jan 3. pii: S0149-7634(18)30523-2. doi: 10.1016/j.neubiorev.2018.12.023. Review.PMID:30611800
- Munthali RJ, Manyema M, Said-Mohamed R, Kagura J, Tollman S, Kahn K, Gómez-Olivé FX, Micklesfield LK, Dunger D, Norris SA. Body composition and physical activity as mediators in the relationship between socioeconomic status and blood pressure in young South African women: a structural equation model analysis. BMJ Open 2018 Dec 19;8(12):e023404. doi: 10.1136/bmjopen-2018-023404 PMID: 30573484PMCID: PMC6303607
- Niu Y, Kane AD, Lusby CM, Allison BJ, Chua YY, Kaandorp JJ, Nevin-Dolan R, Ashmore TJ, Blackmore HL, Derks JB, Ozanne SE, Giussani DA.Maternal Allopurinol Prevents Cardiac Dys- function in Adult Male Offspring Programmed by Chronic Hypoxia During Pregnancy. Hyperten- sion. 2018 Oct;72(4):971-978. PMID: 30354714PMCID: PMC6135482
- Pellegrinelli V, Peirce VJ, Howard L, Virtue S, Türei D, Senzacqua M, Frontini A, Dalley JW, Hor- ton AR, Bidault G, Severi I, Whittle A, Rahmouni K, Saez-Rodriguez J, Cinti S, Davies AM, Vidal- Puig A. Adipocyte-secreted BMP8b mediates adrenergic-induced remodeling of the neuro- vascular network in adipose tissue. Nat Commun. 2018 Nov 26;9(1):4974. doi: 10.1038/s41467- 018-07453-x.PMID:30478315
- Petrus P, Mejhert N, Corrales P, Lecoutre S, Li Q, Maldonado E, Kulyté A, Lopez Y, Campbell M, Acosta JR, Laurencikiene J, Douagi I, Gao H, Martínez-Álvarez C, Hedén P, Spalding KL, Vidal-Puig A, Medina-Gomez G, Arner P. Transforming Growth Factor-β3 Regulates Adipocyte Number in Subcutaneous White Adipose Tissue. Rydén M.Cell Rep. 2018 Oct 16;25(3):551- 560.e5. PMID: 30332637
- Petry CJ, Ong KK, Burling KA, Barker P, Goodburn SF, Perry JRB, Acerini CL, Hughes IA, Painter RC, Afink GB, Dunger DB, O’Rahilly S. Associations of vomiting and antiemetic use in pregnancy with levels of circulating GDF15 early in the second trimester: A nested case-control study. Wellcome Open Res. 2018 Sep 21;3:123. PMID: 30345390 PMCID: PMC6171563
- Rached MT, Millership SJ, Pedroni SMA, Choudhury AI, Costa ASH, Hardy DG, Glegola JA, Ir- vine EE, Selman C, Woodberry MC, Yadav VK, Khadayate S, Vidal-Puig A, Virtue S, Frezza C, Withers DJ. Deletion of myeloid IRS2 enhances adipose tissue sympathetic nerve function and limits obesity. Mol Metab. 2018 Nov 28. pii: S2212-8778(18)31025-1. doi: 10.1016/ j.molmet.2018.11.010. PMID:30553769
- Recino A, Gan SU, Sia KC, Sawyer Y, Trendell J, Kay R, Gribble FM, Reimann F, Foale R, No- taridou M, Holmes N, Lever A, Lee KO, Nathwani A, Cooke A, Calne R, Wallberg M. Immunosuppression overcomes insulin- and vector-specific immune responses that limit effi- cacy of AAV2/8-mediated insulin gene therapy in NOD mice. Gene Ther. 2018 Dec 4. doi: 10.1038/s41434-018-0052-5. PMID:30514969
- Roche EF, McGowan A, Koulouri O, Turgeon MO, Nicholas AK, Heffernan E, El-Khairi R, Abid N, Lyons G, Halsall D, Bonomi M, Persani L, Dattani MT, Gurnell M, Bernard DJ, Schoenmakers N. A novel IGSF1 mutation in a large Irish kindred highlights the need for familial screening in the IGSF1 deficiency syndrome. Clin Endocrinol (Oxf). 2018 Dec;89(6):813-823. doi: 10.1111/ cen.13827. PMID:30086211
- Rudenko O, Shang J, Munk A, Ekberg JP, Petersen N, Engelstoft MS, Egerod KL, Hjorth SA, Wu M, Feng Y, Zhou YP, Mokrosinski J, Thams P, Reimann F, Gribble F, Rehfeld JF, Holst JJ, Tree- bak JT, Howard AD, Schwartz TW. The aromatic amino acid sensor GPR142 controls metabolism through balanced regulation of pancreatic and gut hormones. Mol Metab. 2019 Jan;19:49-64. doi: 10.1016/j.molmet.2018.10.012. Epub 2018 Nov 5. PMID:30472415
- Senyilmaz-Tiebe D, Pfaff DH, Virtue S, Schwarz KV, Fleming T, Altamura S, Muckenthaler MU, Okun JG, Vidal-Puig A, Nawroth P, Teleman AA. Dietary stearic acid regulates mitochondria in vivo in humans. Nat Commun. 2018 Aug 7;9(1):3129. PMID: 30087348PMCID: PMC6081440
- Smith MA, Katsouri L, Virtue S, Choudhury AI, Vidal-Puig A, Ashford MLJ, Withers DJ Calcium Channel CaV2.3 Subunits Regulate Hepatic Glucose Production by Modulating Leptin-Induced Excitation of Arcuate Pro-opiomelanocortin Neurons. Cell Rep. 2018 Oct 9;25(2):278-287.e4. PMID: 30304668 PMCID: PMC6198286
- Speakman JR, Loos RJF, O’Rahilly S, Hirschhorn JN, Allison DB. GWAS for BMI: a treasure trove of fundamental insights into the genetic basis of obesity. Int J Obes (Lond). 2018 Aug;42 (8):1524-1531. PMID: 29980761PMCID: PMC6115287
- Tauschmann M, Thabit H, Bally L, Allen JM, Hartnell S, Wilinska ME, Ruan Y, Sibayan J, Koll- man C, Cheng P, Beck RW, Acerini CL, Evans ML, Dunger DB, Elleri D, Campbell F, Bergenstal RM, Criego A, Shah VN, Leelarathna L, Hovorka R; Closed-loop insulin delivery in suboptimally controlled type 1 diabetes: a multicentre, 12-week randomised trial. Lancet. 2018 Oct 13;392(10155):1321-1329. Erratum in: Lancet. 2018 Oct 13;392 (10155):1310 PMID: 30292578 PMCID: PMC6182127
- Turco MY, Gardner L, Kay RG, Hamilton RS, Prater M, Hollinshead MS, McWhinnie A, Esposito L, Fernando R, Skelton H, Reimann F, Gribble FM, Sharkey A, Marsh SGE, O’Rahilly S, Hem- berger M, Burton GJ, Moffett A. Trophoblast organoids as a model for maternal-fetal interactions during human placentation. Nature. 2018 Dec;564(7735):263-267. doi: 10.1038/s41586-018- 0753-3. Epub 2018 Nov 28.PMID:30487605
- Vidal-Puig A, Enerback S.J “Obesity-associated metabolic complications, the second wave of the tsunami” 14th Key Symposium. Intern Med. 2018 Nov;284(5):447-449. PMID: 30141829
- Virtue S, Petkevicius K, Moreno-Navarrete JM, Jenkins B, Hart D, Dale M, Koulman A, Fernán- dez-Real JM, Vidal-Puig A. Peroxisome Proliferator-Activated Receptor γ2 Controls the Rate of Adipose Tissue Lipid Storage and Determines Metabolic Flexibility. Cell Rep. 2018 Aug 21;24 (8):2005-2012.e7. PMID: 30134163 PMCID: PMC6113930
- Whyte MB, Shojaee-Moradie F, Sharaf SE, Jackson NC, Fielding B, Hovorka R, Mendis J, Rus- sell-Jones D, Umpleby AM.J Lixisenatide reduces chylomicron triacylglycerol due to increased clearance. Clin Endocrinol Metab. 2018 Sep 11. PMID: 30215735PMCID: PMC6300412
- Zangemeister L, Grabenhorst F, Schultz W. Neural Basis for Economic Saving Strategies in Hu- man Amygdala-Prefrontal Reward Circuits. Curr Biol. 2016 Nov 21;26(22):3004-3013. doi: 10.1016/j.cub.2016.09.016. Epub 2016 Oct 20.PMID:27773572
2017
- Ahmed RM, Landin-Romero R, Collet TH, van der Klaauw AA, Devenney E, Henning E, Kiernan MC, Piguet O, Farooqi IS, Hodges JR. Energy expenditure in frontotemporal dementia: a behavioural and imaging study. Brain 2017;140:171-83.
- Anderberg RH, [11 authors; Gribble FM: 8, Reimann F: 9], Skibicka KP. Glucagon-like peptide-1 and its analogues act in the dorsal raphe and modulate central serotonin to reduce appetite and body weight. Diabetes 2017; 66:1062-1073.
- Annamalai AK, Jeyachitra G, Jeyamithra A, Ganeshkumar M, Srinivasan KG, Gurnell M. Gestational Pituitary Apoplexy. Indian J Endocrinol Metab. 2017; 21:484-485.
- Arif S, Gibson VB, Nguyen V, Bingley PJ, Todd JA, Guy C, Dunger DB, Dayan CM, Powrie J, Lorenc A, Peakman M. β-cell specific T-lymphocyte response has a distinct inflammatory phenotype in children with Type 1 diabetes compared with adults. Diabet Med. 2017; 34:419-25.
- Aycan Z, Cangul H, Muzza M, Bas VN, Fugazzola L, Chatterjee VK, Persani L, Schoenmakers N. Digenic DUOX1 and DUOX2 mutations in cases with congenital hypothyroidism. J Clin Endocrinol Metab. 2017. [Epub ahead of print]
- Bally L, Thabit H, Kojzar H, Mader JK, Qerimi-Hyseni J, Hartnell S, Tauschmann M, Allen JM, Wilinska ME, Pieber TR, Evans ML, Hovorka R Day-and-night glycaemic control with closed-loop insulin delivery versus conventional insulin pump therapy in free-living adults with well controlled type 1 diabetes: an open-label, randomised, crossover study. Lancet Diabetes Endocrinol. 2017; 5: 261-270.
- Barnard KD, Wysocki T, Ully V, Mader JK, Pieber TR, Thabit H, Tauschmann M, Leelarathna L, Hartnell S, Acerini CL, Wilinska ME, Dellweg S, Benesch C, Arnolds S, Holzer M, Kojzar H, Campbell F, Yong J, Pichierri J, Hindmarsh P, Heinemann L, Evans ML, Hovorka R Closing the Loop in Adults, Children and Adolescents With Suboptimally Controlled Type 1 Diabetes Under Free Living Conditions: A Psychosocial Substudy. J Diabetes Sci Technol. 2017. [Epub ahead of print]
- Boudellioua I, Mahamad Razali RB, Kulmanov M, Hashish Y, Bajic VB, Goncalves-Serra E, Schoenmakers N, Gkoutos GV, Schofield PN, Hoehndorf R. Semantic prioritization of novel causative genomic variants. PLoS Comput Biol. 2017; 13:e1005500.
- Bulger DA, Fukushige T, Yun S, Semple RK, Hanover JA, Krause MW. Caenorhabditis elegans DAF-2 as a model for human insulin receptoropathies. G3 (Bethesda). 2017; 7:257-68.
- Burke LK, Darwish T, Cavanaugh AR, Virtue S, Roth E, Morro J, Liu SM, Xia J, Dalley JW, Burling K, Chua A, Vidal-Puig A, Schwartz GJ, Blouet C. mTORC1 in AGRP neurons integrates exteroceptive and interoceptive food-related cues in the modulation of adaptive energy expenditure in mice. eLife. 2017; 6: e22848.
- Church D, Cardoso L, Bradbury S, Clarke C, Stears A, Dover A, Halsall D, Semple R. Diagnosis of insulin autoimmune syndrome using polyethylene glycol precipitation and gel filtration chromatography with ex vivo insulin exchange. Clin Endocrinol (Oxf). 2017;86:347-353.
- De Almeida Faria J, Duque-Guimaraes D, Carpenter AAM, Loche E, Ozanne SE. A post-weaning obesogenic diet exacerbates the detrimental effects of maternal obesity on offspring insulin signaling in adipose tissue. Sci Rep. 2017; 24: 44949.
- Diederen KM, Ziauddeen H, Vestergaard MD, Spencer T, Schultz W, Fletcher PC. Dopamine Modulates Adaptive Prediction Error Coding in the Human Midbrain and Striatum. J Neurosci. 2017; 37:1708-1720.
- Duque-Guimarães DE, de Almeida-Faria J, Ong TP, Ozanne SE. Pulsed SILAC as a approach for miRNA targets identification in cell culture. Methods Mol Biol. 2017;1546:149-59.
- Emami A, Willinska ME, Thabit H, Leelarathna L, Hartnell S, Dellweg S, Benesch C, Mader JK, Holzer M, Kojzar H, Pieber TR, Arnolds S, Evans ML, Hovorka R. Behavioral Patterns and Associations with Glucose Control During 12-Week Randomized Free-Living Clinical Trial of Day and Night Hybrid Closed-Loop Insulin Delivery in Adults with Type 1 Diabetes. Diabetes Technol Ther. 2017; 19:433-437.
- Farrington C, Stewart ZA, Barnard K, Hovorka R, Murphy HR. Experiences of closed-loop insulin delivery among pregnant women with Type 1 diabetes. Diabet Med. 2017. [Epub ahead of print]
- Fernandez-Twinn DS, Gascoin G, Musial B, Carr S, Duque-Guimaraes D, Blackmore HL, Alfaradhi MZ, Loche E, Sferruzzi-Perri A, Fowden AL, Ozanne SE. Exercise rescues obese mothers’ insulin sensitivity, placental hypoxia and offspring insulin sensitivity. Sci Rep. 2017;7:44650.
- García-García F, Hovorka R, Wilinska ME, Elleri D, Hernando ME. Modelling the effect of insulin on the disposal of meal-attributable glucose in type 1 diabetes. Med Biol Eng Comput. 2017; 55:271-282.
- Graff M, Scott RA, [259 authors], CHARGE Consortium.; EPIC-InterAct Consortium.; PAGE Consortium., [1 author], Barroso I: 262, [18 authors], Kilpeläinen TO. Genome-wide physical activity interactions in adiposity – A meta-analysis of 200,452 adults. PLoS Genet. 2017; 13:e1006528.
- Hameed S, Patterson M, Dhillo WS, Rahman SA, Ma Y, Holton C, Gogakos A, Yeo GSH, Lam BYH, Polex-Wolf J, Fenske W, Bell J, Anastasovska J, Samarut J, Bloom SR, Bassett JHD, Williams GR, Gardiner JV Thyroid Hormone Receptor Beta in the Ventromedial Hypothalamus Is Essential for the Physiological Regulation of Food Intake and Body Weight. Cell Rep. 2017;19:2202-2209.
- Hendricks AE, [30 authors] O’Rahilly S: 32, Zeggini E, Barroso I: 34, Farooqi IS. Understanding Society Scientific Group; EPIC-CVD Consortium; UK10K Consortium. Rare Variant Analysis of Human and Rodent Obesity Genes in Individuals with Severe Childhood Obesity. Sci Rep. 2017; 7:4394.
- Improda N, Ponmani C, Schoenmakers N, Senniappan S, Atterbury A, Barnicoat A, Chatterjee K, Dattani MT. Intrafamilial Phenotypic Variability and Consequences of Non-Compliance with Treatment in Congenital Adrenal Hyperplasia and Congenital Hypothyroidism within a Single Family. Horm Res Paediatr. 2017. [Epub ahead of print]
- Justice AE, [297 authors], Barroso I 299, [16 authors], Cupples LA. Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits. Nat Commun. 2017; 8:14977.
- Koseki H, Donegá M, Lam BY, Petrova V, van Erp S, Yeo GS, Kwok JC, Ffrench-Constant C, Eva R, Fawcett J. Selective Rab11 transport and the intrinsic regenerative ability of CNS axons. eLife. 2017. [Epub ahead of print]
- Lam BYH, Cimino I, Polex-Wolf J, Nicole Kohnke S, Rimmington D, Iyemere V, Heeley N, Cossetti C, Schulte R, Saraiva LR, Logan DW, Blouet C, O’Rahilly S, Coll AP, Yeo GSH Heterogeneity of hypothalamic pro-opiomelanocortin-expressing neurons revealed by single-cell RNA sequencing. Mol Metab. 2017; 6:383-392.
- Leiter SM, Parker VER, Welters A, Knox R, Rocha N, Clark G, Payne F, Lotta L, Harris J, Guerrero-Fernández J, González-Casado I, García-Miñaur S, Gordo G, Wareham N, Martínez-Glez V, Allison M, O’Rahilly S, Barroso I, Meissner T, Davies S, Hussain K, Temple K, Barreda-Bonis AC, Kummer S, Semple RK. Hypoinsulinaemic, hypoketotic hypoglycaemia due to mosaic genetic activation of PI3-kinase. Eur J Endocrinol. 2017; 177:175-186.
- Li M, Li Y, [60 authors], CHARGE Glycemic-T2D Working Group, CHARGE Blood Pressure Working Group, [94 authors], Chu AY. SOS2 and ACP1 Loci Identified through Large-Scale Exome Chip Analysis Regulate Kidney Development and Function. J Am Soc Nephrol. 2017; 28:981-994.
- Lin X, Lim IY, Wu Y, Teh AL, Chen L, Aris IM, Soh SE, Tint MT, MacIsaac JL, Morin AM, Yap F, Tan KH, Saw SM, Kobor MS, Meaney MJ, Godfrey KM, Chong YS, Holbrook JD, Lee YS, Gluckman PD, Karnani N; GUSTO study group. Developmental pathways to adiposity begin before birth and are influenced by genotype, prenatal environment and epigenome. BMC Med. 2017; 15:50.
- Lotta LA, [29 authors], O’Rahilly S, Scott RA. Integrative genomic analysis implicates limited peripheral adipose storage capacity in the pathogenesis of human insulin resistance. Nat Genet. 2017; 49:17-26. Corrigendum 2017; 49:317.
- Ma D, Ozanne SE, Guest PC A Protocol for Producing the Maternal Low-Protein Rat Model: A Tool for Preclinical Proteomic Studies. Adv Exp Med Biol. 2017; 974:251-255.
- Maniero C, Garg S, Zhao W, Johnson TI, Zhou J, Gurnell M, Brown MJ. NEFM (Neurofilament Medium) Polypeptide, a Marker for Zona Glomerulosa Cells in Human Adrenal, Inhibits D1R (Dopamine D1 Receptor)-Mediated Secretion of Aldosterone. Hypertension. 2017; 70:357-364.
- Manning A, [192 authors], O’Rahilly SP: 194, [6 authors], Barroso I: 201, [60 authors], Lindgren CM. A Low-Frequency Inactivating AKT2 Variant Enriched in the Finnish Population Is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk. Diabetes. 2017; 66:2019-2032.
- Martínez-Sánchez N, [21 authors], Chatterjee K: 22, [5 authors], Coll AP: 28, Vidal-Puig A: 29, [10 authors], López M. Hypothalamic AMPK-ER Stress-JNK1 Axis Mediates the Central Actions of Thyroid Hormones on Energy Balance. Cell Metab. 2017; 26:212-229.
- Mele L, Carobbio S, Brindani N, Curti C, Rodriguez-Cuenca S, Bidault G, Mena P, Zanotti I, Vacca M, Vidal-Puig A, Del Rio D Phenyl-γ-valerolactones, flavan-3-ol colonic metabolites, protect brown adipocytes from oxidative stress without affecting their differentiation or function. Mol Nutr Food Res. 2017. [Epub ahead of print]
- Minic M, Rocha N, Harris J, Groeneveld MP, Leiter S, Wareham N, Sleigh A, De Lonlay P, Hussain K, O’Rahilly S, Semple RK Constitutive activation of AKT2 in humans leads to hypoglycemia without fatty liver or metabolic dyslipidemia. J Clin Endocrinol Metab. 2017; 102:2914-2921.
- Musial B, Vaughan O, Fernandez-Twinn DS, Voshol P, Ozanne SE, Fowden A, Sferruzzi-Perri A. A Western-style obesogenic diet alters maternal metabolic physiology with consequences for fetal nutrient acquisition in mice. J Physiol. 2017. [Epub ahead of print]
- Nøhr AC, Shehata MA, Hauser AS, Isberg V, Mokrosinski J, Andersen KB, Farooqi IS, Pedersen DS, Gloriam DE, Bräuner-Osborne H. The orphan G protein-coupled receptor GPR139 is activated by the peptides: Adrenocorticotropic hormone (ACTH), α-, and β-melanocyte stimulating hormone (α-MSH, and β-MSH), and the conserved core motif HFRW. Neurochem Int. 2017;102:105-13.
- Nus M, Sage AP, Lu Y, Masters L, Lam BYH, Newland S, Weller S, Tsiantoulas D, Raffort J, Marcus D, Finigan A, Kitt L, Figg N, Schirmbeck R, Kneilling M, Yeo GSH, Binder CJ, de la Pompa JL, Mallat Z. Marginal zone B cells control the response of follicular helper T cells to a high-cholesterol diet. Nat Med. 2017; 23:601-610.
- Olcese C, [40 authors], UK10K Rare Group, [4 authors], Mitchison HM. X-linked primary ciliary dyskinesia due to mutations in the cytoplasmic axonemal dynein assembly factor PIH1D3. Nat Commun. 2017; 8:14279.
- O’Reilly MW, Kempegowda P, Walsh M, Taylor AE, Manolopoulos KN, Allwood JW, Semple RK, Hebenstreit D, Dunn WB, Tomlinson JW, Arlt W.J AKR1C3-mediated adipose androgen generation drives lipotoxicity in women with polycystic ovary syndrome. Clin Endocrinol Metab. 2017; [Epub ahead of print].
- Ouyang J, Hardy R, Brown M, Helliwell T, Gurnell M, Cuthbertson DJ. 11C-metomidate PET-CT scanning can identify aldosterone-producing adenomas after unsuccessful lateralisation with CT/MRI and adrenal venous sampling. J Hum Hypertens. 2017; 31:483-484.
- Pestana D, Teixeira D, Meireles M, Marques C, Norberto S, Sá C, Fernandes VC, Correia-Sá L, Faria A, Guardão L, Guimarães JT, Cooper WN, Sandovici I, Domingues VF, Delerue-Matos C, Monteiro R, Constância M, Calhau C.Adipose tissue dysfunction as a central mechanism leading to dysmetabolic obesity triggered by chronic exposure to p,p’-DDE. Sci Rep. 2017; 7:2738.
- Petry CJ, Mooslehner K, Prentice P, Hayes MG, Nodzenski M, Scholtens DM, Hughes IA, Acerini CL, Ong KK, Lowe WL Jr, Dunger DB. Associations between a fetal imprinted gene allele score and late pregnancy maternal glucose concentrations. Diabetes Metab. 2017. [Epub ahead of print]
- Pompa A, De Marchis F, Pallotta MT, Benitez-Alfonso Y, Jones A, Schipper K, Moreau K, Žárský V, Di Sansebastiano GP, Bellucci M. Unconventional Transport Routes of Soluble and Membrane Proteins and Their Role in Developmental Biology. Int J Mol Sci. 2017; 18(4).
- Psichas A, Tolhurst G, Brighton CA, Gribble FM, Reimann F. Mixed Primary Cultures of Murine Small Intestine Intended for the Study of Gut Hormone Secretion and Live Cell Imaging of Enteroendocrine Cells. J Vis Exp. 2017; 122:55687.
- Rocha NM, [14 authors], Barroso I: 16, [10 authors], O’Rahilly SI: 27, [2 authors], Savage DB: 30, Semple RK Human biallelic MFN2 mutations induce mitochondrial dysfunction, upper body adipose hyperplasia, and suppression of leptin expression. eLife. 2017; 6: e23813.
- Ruan Y, Thabit H, Leelarathna L, Hartnell S, Willinska ME, Tauschmann M, Dellweg S, Benesch C, Mader JK, Holzer M, Kojzar H, Evans ML, Pieber TR, Arnolds S, Hovorka R; AP@home consortium. Faster insulin action is associated with improved glycemic outcomes during closed-loop insulin delivery and sensor-augmented pump therapy in adults with type 1 diabetes. Diabetes Obes Metab. 2017. [Epub ahead of print]
- Sferruzzi-Perri AN, Sandovici I, Constancia M, Fowden AL. Placental phenotype and the insulin-like growth factors: resource allocation to fetal growth. J Physiol. 2017; 595:5057-5093.
- Taku N, Gurnell M, Burnet N, Jena R. Time dependence of radiation-induced hypothalamic-pituitary axis dysfunction in adults treated for non-pituitary, intracranial neoplasms. Clin Oncol (R Coll Radiol). 2017;29:34-41.
- Teo AE, Garg S, Johnson TI, Zhao W, Zhou J, Gomez-Sanchez CE, Gurnell M, Brown MJ. Physiological and Pathological Roles in Human Adrenal of the Glomeruli-Defining Matrix Protein NPNT (Nephronectin). Hypertension. 2017; 69:1207-1216. Apr 17.
- Thabit H, Hartnell S, Allen JM, Lake A, Wilinska ME, Ruan Y, Evans ML, Coll AP, Hovorka R. Closed-loop insulin delivery in inpatients with type 2 diabetes: a randomised, parallel-group trial. R.Lancet Diabetes Endocrinol. 2017; 5:117-124.
- Tripolszki K, Farkas K, Sulák A, Szolnoky G, Duga B, Melegh B, Knox RG, Parker VER, Semple RK, Kemény L, Széll M, Nagy N. Atypical neurofibromatosis type 1 with unilateral limb hypertrophy mimicking overgrowth syndrome. Clin Exp Dermatol. 2017. [Epub ahead of print]
- Tsoukalas M, Psichas A, Reimann F, Gribble FM, Lobstein A, Urbain A. Pregnane glycosides from Cynanchum menarandrense. Steroids. 2017; 125:27-32.
- Tsuchiya Y, Peak-Chew S, Newell C, Miller-Aidoo S, Mangal S, Zhyvoloup A, Baković J, Malanchuk O, Pereira G, Kotiadis V, Szabadkai G, Duchen M, Campbell M, Rodriguez Cuenca S, Vidal-Puig A, James A, Murphy MP, Filonenko V, Skehel M, Gout I. Protein CoAlation: A Redox-Regulated Protein Modification by Coenzyme A in Mammalian Cells. Biochem J. 2017; 474:2489-2508.
- van der Klaauw AA, Ziauddeen H, Keogh JM, Henning E, Dachi S, Fletcher PC, Farooqi IS Oxytocin administration suppresses hypothalamic activation in response to visual food cues. Sci Rep. 2017; 7:4266.eo CR, Agrawal M, Hoon S, Shabbir A, Shrivastava MK, Huang S, Khoo CM, Chhay V, Yassin MS, Tai ES, Vidal-Puig A, Toh SA. SGBS cells as a model of human adipocyte browning: A comprehensive comparative study with primary human white subcutaneous adipocytes. Sci Rep. 2017; 7:4031.
- van Gucht ALM, Moran C, Meima ME, Visser WE, Chatterjee K, Visser TJ, Peeters RP. Resistance to Thyroid Hormone due to Heterozygous Mutations in Thyroid Hormone Receptor Alpha. Curr Top Dev Biol. 2017; 125:337-355.
- Vasudevan P, Powell C, Nicholas AK, Scudamore I, Greening J, Park SM, Schoenmakers N. Intrauterine death following intraamniotic triiodothyronine and thyroxine therapy for fetal goitrous hypothyroidism associated with polyhydramnios and caused by a thyroglobulin mutation. Endocrinol Diabetes Metab Case Rep. 2017; 17-0040.
- Wheeler SE, Stacey HM, Nahaei Y, Hale SJ, Hardy AB, Reimann F, Gribble FM, Larraufie P, Gaisano HY, Brubaker PL. The SNARE Protein, Syntaxin1a, Plays an Essential Role in Biphasic Exocytosis of the Incretin Hormone, Glucagon-Like Peptide-1. Diabetes. 2017; 66:2327-2338.
- Yeo CR, Agrawal M, Hoon S, Shabbir A, Shrivastava MK, Huang S, Khoo CM, Chhay V, Yassin MS, Tai ES, Vidal-Puig A, Toh SA. SGBS cells as a model of human adipocyte browning: A comprehensive comparative study with primary human white subcutaneous adipocytes. Sci Rep. 2017: 7:4031.
2016
(* Open access publications)
- Adriaenssens AE, Svendsen B, Lam BY, Yeo GS, Holst JJ, Reimann F, Gribble FM. Transcriptomic profiling of pancreatic alpha, beta and delta cell populations identifies delta cells as a principal target for ghrelin in mouse islets. Diabetologia 2016;59:2156-65. *
- Ahmed RM, Irish M, Henning E, Dermody N, Bartley L, Kiernan MC, Piguet O, Farooqi S, Hodges JR. Assessment of eating behavior disturbance and associated neural networks in frontotemporal dementia. JAMA Neurol. 2016;73:282-90.
- Aiken CE, Tarry-Adkins JL, Penfold NC, Dearden L, Ozanne SE. Decreased ovarian reserve, dysregulation of mitochondrial biogenesis, and increased lipid peroxidation in female mouse offspring exposed to an obesogenic maternal diet. FASEB J. 2016;30:1548-56. *
- Alfaradhi MZ, Kusinski LC, Fernandez-Twinn DS, Pantaleão LC, Carr SK, Ferland-McCollough D, Yeo GS, Bushell M, Ozanne SE. Maternal obesity in pregnancy developmentally programs adipose tissue inflammation in young, lean male mice offspring. Endocrinology 2016;157:4246-56. *
- Allison BJ, Kaandorp JJ, Kane AD, Camm EJ, Lusby C, Cross CM, Nevin-Dolan R, Thakor AS, Derks JB, Tarry-Adkins JL, Ozanne SE, Giussani DA. Divergence of mechanistic pathways mediating cardiovascular aging and developmental programming of cardiovascular disease. FASEB J. 2016;30:1968-75. *
- Anesten F, Holt MK, Schéle E, Pálsdóttir V, Reimann F, Gribble FM, Safari C, Skibicka KP, Trapp S, Jansson JO. Preproglucagon neurons in the hindbrain have IL-6 receptor-α and show Ca2+ influx in response to IL-6. Am J Physiol Regul Integr Comp Physiol. 2016;311:R115-23. *
- Baig S, Parvaresh Rizi E, Shabeer M, Chhay V, Mok SF, Loh TP, Magkos F, Vidal-Puig A, Tai ES, Khoo CM, Toh SA. Metabolic gene expression profile in circulating mononuclear cells reflects obesity-associated metabolic inflexibility. Nutr Metab (Lond). 2016;13:74. *
- Boldt K, [54 authors], Group UKRD. An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. Nat Commun. 2016;7:11491. *
- Breen DP, Nombela C, Vuono R, Jones PS, Fisher K, Burn DJ, Brooks DJ, Reddy AB, Rowe JB, Barker RA. Hypothalamic volume loss is associated with reduced melatonin output in Parkinson’s disease. Mov Disord. 2016;31:1062-6. *
- Burberry A, [15 authors; Merkle FT: 9], Eggan K. Loss-of-function mutations in the C9ORF72 mouse ortholog cause fatal autoimmune disease. Sci Transl Med. 2016;8:347ra93. *
- Burke LK, [17 authors], Evans ML, Heisler LK. Sex difference in physical activity, energy expenditure and obesity driven by a subpopulation of hypothalamic POMC neurons. Mol Metab. 2016;5:245-52. *
- Carmody D, Ladsaria SS, Buikema RK, Semple RK, Greeley SAW. Successful rhIGF1 treatment for over 5 years in a patient with severe insulin resistance due to homozygous insulin receptor mutation. Diabet Med. 2016;33:e8-12. *
- Castillo SD, [26 authors; Semple RK: 23], Vanhaesebroeck B. Somatic activating mutations in Pik3ca cause sporadic venous malformations in mice and humans. Sci Transl Med. 2016;8:332ra43.
- Challis BG, Kandasamy N, Powlson AS, Koulouri O, Annamalai AK, Happerfield L, Marker AJ, Arends MJ, Nik-Zainal S, Gurnell M. Familial adrenocortical carcinoma in association with Lynch syndrome. J Clin Endocrinol Metab. 2016;101:2269-72. *
- Challis BG, Lim CT, Cluroe A, Cameron E, O’Rahilly S. The McKittrick-Wheelock syndrome: a rare cause of curable diabetes. Endocrinol Diabetes Metab Case Rep. 2016;160013. *
- Collet TH, van der Klaauw AA, Henning E, Keogh JM, Suddaby D, Dachi SV, Dunbar S, Kelway S, Dickson SL, Farooqi IS, Schmid SM. The sleep/wake cycle is directly modulated by changes in energy balance. Sleep 2016;39:1691-700. *
- Correia-Melo C, [26 authors; Vidal-Puig A: 19], Passos JF. Mitochondria are required for pro-ageing features of the senescent phenotype. EMBO J. 2016;35:724-42.*
- Dalgaard K, [28 authors; Yeo GS: 19, O’Rahilly S: 20, Coll AP: 27], Pospisilik JA. Trim28 haploinsufficiency triggers bi-stable epigenetic obesity. Cell 2016;164:353-64. *
- Demir T, Onay H, Savage DB, Temeloglu E, Uzum AK, Kadioglu P, Altay C, Ozen S, Demir L, Cavdar U, Akinci B. Familial partial lipodystrophy linked to a novel peroxisome proliferator activator receptor -γ (PPARG) mutation, H449L: a comparison of people with this mutation and those with classic codon 482 Lamin A/C (LMNA) mutations. Diabet Med. 2016;33:1445-50.
- Dennedy MC, Annamalai AK, Prankerd Smith O, Freeman N, Vengopal K, Graggaber J, Koulouri O, Powlson AS, Shaw A, Halsall DJ, Gurnell M. Low DHEAS: a sensitive and specific test for detection of subclinical hypercortisolism in adrenal incidentalomas. J Clin Endocrinol Metab. 2016;jc20162718.
- Diederen KM, Spencer T, Vestergaard MD, Fletcher PC, Schultz W. Adaptive prediction error coding in the human midbrain and striatum facilitates behavioural adaptation and learning efficiency. Neuron. 2016;90:1127-38. doi: *
- Duque-Guimarães DE, de Almeida-Faria J, Ong TP, Ozanne SE. Pulsed SILAC as a approach for miRNA targets identification in cell culture. Methods Mol Biol. 2017;1546:149-59.
- Dusaulcy R, Handgraaf S, Heddad-Masson M, Visentin F, Vesin C, Reimann F, Gribble F, Philippe J, Gosmain Y. α-cell dysfunctions and molecular alterations in male insulinopenic diabetic mice are not completely corrected by insulin. Endocrinology 2016;157:536-47.
- Edgar RS, Stangherlin A, Nagy AD, Nicoll MP, Efstathiou S, O’Neill JS, Reddy AB. Cell autonomous regulation of herpes and influenza virus infection by the circadian clock. Proc Natl Acad Sci USA. 2016;113:10085-90. *
- Ekberg JH, [14 authors; Gribble FM: 10, Reiman F: 11], Schwartz TW. GPR119, a major enteroendocrine sensor of dietary triglyceride metabolites coacting in synergy With FFA1 (GPR40). Endocrinology 2016;157:4561-9.
- Farrington C, Allen J, Tauschmann M, Randell T, Trevelyan N, Hovorka R. Factors affecting recruitment of participants for studies of diabetes technology in newly diagnosed youth with type 1 diabetes: a qualitative focus group study with parents and children. Diabetes Technol Ther. 2016;18:568-73. *
- Flint TR, Janowitz T, Connell CM, Roberts EW, Denton AE, Coll AP, Jodrell DI, Fearon DT. Tumor-induced IL-6 reprograms host metabolism to suppress anti-tumor immunity. Cell Metab. 2016;24:672-84. *
- Fuchsberger C, [301 authors; O’Rahilly SP: 208], McCarthy MI. The genetic architecture of type 2 diabetes. Nature 2016;536:41-7. *
- Gathercole LL, [13 authors; Semple RK: 11], Geberhiwot T. Advanced non-alcoholic fatty liver disease and adipose tissue fibrosis in patients with Alström syndrome. Liver Int. 2016;36:1704-12.
- Giraud K, Pontin M, Sharples LD, Fletcher P, Dalgleish T, Eden A, Jenkins DP, Vuylsteke A. Use of a structured mirrors intervention does not reduce delirium incidence but may improve factual memory encoding in cardiac surgical ICU patients aged over 70 years: a pilot time-cluster randomized controlled trial. Front Aging Neurosci. 2016;8:228.
- Gripp KW, Baker L, Kandula V, Conard K, Scavina M, Napoli JA, Griffin GC, Thacker M, Knox RG, Clark GR, Parker VER, Semple R, Mirzaa G, Keppler-Noreuil KM. Nephroblastomatosis or Wilms tumor in a fourth patient with a somatic PIK3CA mutation. Am J Med Genet A. 2016;170:2559-69.
- Groeneveld MP, Brierley GV, Rocha NM, Siddle K, Semple RK. Acute knockdown of the insulin receptor or its substrates Irs1 and 2 in 3T3-L1 adipocytes suppresses adiponectin production. Sci Rep. 2016 Feb 18;6:21105. *
- Hall Z, Bond NJ, Ashmore T, Sanders F, Ament Z, Wang X, Murray AJ, Bellafante E, Virtue S, Vidal-Puig A, Allison M, Davies SE, Koulman A, Vacca M, Griffin JL. Lipid zonation and phospholipid remodeling in nonalcoholic fatty liver disease. Hepatology 2016;epub ahead of print.
- Heppolette CA, Chen JH, Carr SK, Palmer DB, Ozanne SE. The effects of aging and maternal protein restriction during lactation on thymic involution and peripheral immunosenescence in adult mice. Oncotarget 2016;7:6398-409. *
- Holland ML, Lowe R, Caton PW, Gemma C, Carbajosa G, Danson AF, Carpenter AA, Loche E, Ozanne SE, Rakyan VK. Early-life nutrition modulates the epigenetic state of specific rDNA genetic variants in mice. Science 2016;353:495-8.
- Hollands GJ, Marteau TM, Fletcher PC. Non-conscious processes in changing health-related behaviour: a conceptual analysis and framework. Health Psychol Rev. 2016;10:381-394. *
- Huang-Doran I, [18 authors], Savage DB, Murphy R, O’Rahilly S, Barroso I, Semple RK. Insulin resistance uncoupled from dyslipidemia due to C-terminal PIK3R1 mutations. JCI Insight. 2016;1:e88766. *
- Inman M, Daneman D, Curtis J, Sochett E, Elia Y, Dunger DB, Deanfield J, Mahmud FH. Assessing social determinants of health in a pediatric diabetes clinical research trial: Are recruited subjects representative of the larger clinical population? Diabetes Res Clin Pract. 2016;113:41-3.
- Joustra SD, Heinen CA, Schoenmakers N, Bonomi M, Ballieux BEPB, Turgeon MO, Bernard DJ, Fliers E, van Trotsenburg ASP, Losekoot M, Persani L, Wit JM, Biermasz NR, Pereira AM, Oostdijk W, Group ICC. IGSF1 deficiency: lessons from an extensive case series and recommendations for clinical management. J Clin Endocrinol Metab. 2016;101:1627-36. *
- Joustra SD, Schoenmakers N, [26 authors; Chatterjee K: 22], van Trotsenburg AS. The IGSF1 deficiency syndrome: characteristics of male and female patients. J Clin Endocrinol Metab. 2013;98:4942-52.
- Kandasamy N, Garfinkel SN, Page L, Hardy B, Critchley HD, Gurnell M, Coates JM. Interoceptive ability predicts survival on a London trading floor. Sci Rep. 2016;6:32986. *
- Kilpeläinen TO, [175 authors; Savage DB: 99], Loos RJ. Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels. Nat Commun. 2016;7:10494. *
- Kim HS, [15 authors; Yeo GS: 9], Lee MG. A coding variant in FTO confers susceptibility to thiopurine-induced leukopenia in East Asian patients with IBD. Gut 2016;pii:gutjnl-2016-311921.
- Koulouri O, Hoole AC, English P, Allinson K, Antoun N, Cheow H, Burnet NG, Donnelly N, Mannion RJ, Gurnell M. Localisation of an occult thyrotropinoma with (11)C-methionine PET-CT before and after somatostatin analogue therapy. Lancet Diabetes Endocrinol. 2016;4:1050.
- Koulouri O, [28 authors], Gurnell M. Successful treatment of residual pituitary adenoma in persistent acromegaly following localisation by 11C-methionine PET co-registered with MRI. Eur J Endocrinol. 2016;175:485-98.
- Koulouri O, Nicholas AK, Schoenmakers E, Mokrosinski J, Lane F, Cole T, Kirk J, Farooqi IS, Chatterjee VK, Gurnell M, Schoenmakers N. A novel thyrotropin-releasing hormone receptor missense mutation (P81R) in central congenital hypothyroidism. J Clin Endocrinol Metab. 2016;101:847-51. *
- Kuhre RE, Wewer Albrechtsen NJ, Deacon CF, Balk-Møller E, Rehfeld JF, Reimann F, Gribble FM, Holst JJ. Peptide production and secretion in GLUTag, NCI-H716, and STC-1 cells: a comparison to native L-cells. J Mol Endocrinol. 2016;56:201-11.
- Langeveld M, Tan CY, Soeters MR, Virtue S, Ambler GK, Watson LP, Murgatroyd PR, Chatterjee VK, Vidal-Puig A. Mild cold effects on hunger, food intake, satiety and skin temperature in humans. Endocr Connect. 2016;5:65-73. *
- Leelarathna L, Thabit H, Hartnell S, Willinska ME, Dellweg S, Benesch C, Mader JK, Holzer M, Kojzar H, Evans ML, Arnolds S, Pieber TR, Hovorka R, AP@home Consortium. Rapid benefits of structured optimization and sensor-augmented insulin pump therapy in adults with type 1 diabetes. J Diabetes Sci Technol. 2016;pii:1932296816654715.
- Lie S, Morrison JL, Williams-Wyss O, Suter CM, Humphreys DT, Ozanne SE, Zhang S, MacLaughlin SM, Kleemann DO, Walker SK, Roberts CT, McMillen IC. Impact of maternal undernutrition around the time of conception on factors regulating hepatic lipid metabolism and microRNAs in singleton and twin fetuses. Am J Physiol Endocrinol Metab. 2016;310:E148-59. *
- Lotta LA, [26 authors; O’Rahilly S: 25], Langenberg C. Genetic predisposition to an impaired metabolism of the branched-chain amino acids and risk of type 2 diabetes: a mendelian randomisation analysis. PLoS Med. 2016;13:e1002179. *
- Lotta LA, [39 authors; O’Rahilly S: 35], Wareham NJ. Association between low-density lipoprotein cholesterol-lowering genetic variants and risk of type 2 diabetes: a meta-analysis. JAMA 2016;316:1383-91.
- Lu L, Koulman A, Petry CJ, Jenkins B, Matthews L, Hughes IA, Acerini CL, Ong KK, Dunger DB. An unbiased lipidomics approach identifies early second trimester lipids predictive of maternal glycemic traits and gestational diabetes mellitus. Diabetes Care 2016;39:2232-9. *
- Maahs DM, [22 authors; Hovorka R: 11], Lum JW. Outcome Measures for Artificial Pancreas Clinical Trials: A Consensus Report. Diabetes Care 2016;39:1175-9.
- Majithia AR, [24 authors, O’Rahilly S: 19], Altshuler D. Prospective functional classification of all possible missense variants in PPARG. Nat Genet. 2016;48:1570-5. *
- Manning KE, McAllister CJ, Ring HA, Finer N, Kelly CL, Sylvester KP, Fletcher PC, Morrell NW, Garnett MR, Manford MR, Holland AJ. Novel insights into maladaptive behaviours in Prader-Willi syndrome: serendipitous findings from an open trial of vagus nerve stimulation. J Intellect Disabil Res. 2016;60:149-55. *
- Marelli F, Carra S, Agostini M, Cotelli F, Peeters R, Chatterjee K, Persani L. Patterns of thyroid hormone receptor expression in zebrafish and generation of a novel model of resistance to thyroid hormone action. Mol Cell Endocrinol. 2016;424:102-17.
- Martin-Gronert MS, Fernandez-Twinn DS, Bushell M, Siddle K, Ozanne SE. Cell-autonomous programming of rat adipose tissue insulin signalling proteins by maternal nutrition. Diabetologia 2016;59:1266-75. *
- Martin-Gronert MS, Stocker CJ, Wargent ET, Cripps RL, Garfield AS, Jovanovic Z, D’Agostino G, Yeo GS, Cawthorne MA, Arch JR, Heisler LK, Ozanne SE. 5-HT2A and 5-HT2C receptors as hypothalamic targets of developmental programming in male rats. Dis Model Mech. 2016;9:401-12.*
- Martínez R, Kapravelou G, Porres JM, Melesio AM, Heras L, Cantarero S, Gribble FM, Parker H, Aranda P, López-Jurado M. Medicago sativa L, a functional food to relieve hypertension and metabolic disorders in a spontaneously hypertensive rat model. Journal of Functional Foods 2016;26:470-84.
- Medic N, Ziauddeen H, Ersche KD, Farooqi IS, Bullmore ET, Nathan PJ, Ronan L, Fletcher PC. Increased body mass index is associated with specific regional alterations in brain structure. Int J Obes (Lond). 2016;40:1177-82. *
- Medic N, Ziauddeen H, Forwood SE, Davies KM, Ahern AL, Jebb SA, Marteau TM, Fletcher PC. The presence of real food usurps hypothetical health value judgment in overweight people. 2016;3.pii: ENEURO.0025-16.2016. *
- Meek CL, Lewis HB, Vergese B, Park A, Reimann F, Gribble F. The effect of encapsulated glutamine on gut peptide secretion in human volunteers. Peptides 2016;77:38-46. *
- Morton NM, [31 authors; Vidal-Puig A: 29], Horvat S. Genetic identification of thiosulfate sulfurtransferase as an adipocyte-expressed antidiabetic target in mice selected for leanness. Nat Med. 2016;22:771-9.
- Moss CE, Glass LL, Diakogiannaki E, Pais R, Lenaghan C, Smith DM, Wedin M, Bohlooly-Y M, Gribble FM, Reimann F. Lipid derivatives activate GPR119 and trigger GLP-1 secretion in primary murine L-cells. Peptides 2016 Mar;77:16-20. *
- Musial B, Fernandez-Twinn DS, Vaughan OR, Ozanne SE, Voshol P, Sferruzzi-Perri AN, Fowden AL. Proximity to delivery alters insulin sensitivity and glucose metabolism in pregnant mice. Diabetes 2016;65:851-60. *
- Neupane S, Peverall R, Richmond G, Blaikie TP, Taylor D, Hancock G, Evans ML. Exhaled breath isoprene rises during hypoglycemia in type 1 diabetes. Diabetes Care 2016;39:e97-8.
- Nicholas AK, [33 authors], Chatterjee VK, Anderson CA, Schoenmakers N. Comprehensive screening of eight known causative genes in congenital hypothyroidism with gland-in-situ. J Clin Endocrinol Metab. 2016;101:4521-31. *
- Nicholas AK, Jaleel S, Lyons G, Schoenmakers E, Dattani MT, Crowne E, Bernhard B, Kirk J, Roche EF, Chatterjee VK, Schoenmakers N. Molecular spectrum of TSHβ subunit gene defects in central hypothyroidism in the UK and Ireland. Clin Endocrinol (Oxf). 2016; Epub ahead of print.
- Novoselova TV, Larder R, Rimmington D, Lelliott C, Wynn EH, Gorrigan RJ, Tate PH, Guasti L; Sanger Mouse Genetics Project, O’Rahilly S, Clark AJ, Logan DW, Coll AP, Chan LF. Loss of Mrap2 is associated with Sim1 deficiency and increased circulating cholesterol. J Endocrinol. 2016;230:13-26. *
- Overduin J, Collet TH, Medic N, Henning E, Keogh JM, Forsyth F, Stephenson C, Kanning MW, Ruijschop RM, Farooqi IS, van der Klaauw AA. Failure of sucrose replacement with the non-nutritive sweetener erythritol to alter GLP-1 or PYY release or test meal size in lean or obese people. Appetite 2016;107:596-603. *
- Pais R, Gribble FM, Reimann F. Signalling pathways involved in the detection of peptones by murine small intestinal enteroendocrine L-cells. Peptides 2016;77:9-15. *
- Pais R, Rievaj J, Larraufie P, Gribble F, Reimann F. Angiotensin II type 1 receptor-dependent GLP-1 and PYY secretion in mice and humans. Endocrinology 2016;157:3821-3831. *
- Pais R, Rievaj J, Meek C, De Costa G, Jayamaha S, Alexander RT, Reimann F, Gribble F. Role of enteroendocrine L-cells in arginine vasopressin-mediated inhibition of colonic anion secretion. J Physiol. 2016;594:4865-78. *
- Parvaresh Rizi E, Baig S, Shabeer M, Teo Y, Mok SF, Loh TP, Magkos F, Virtue S, Vidal-Puig A, Tai ES, Khoo CM, Toh SA. Meal rich in carbohydrate, but not protein or fat, reveals adverse immunometabolic responses associated with obesity. Nutr J. 2016;15:100. *
- Pauliina Markkula S, Lyons D, Yueh CY, Riches C, Hurst P, Fielding B, Heisler LK, Evans ML. Intracerebroventricular catalase reduces hepatic insulin sensitivity and increases responses to hypoglycemia in rats. Endocrinology 2016;157:4669-76. *
- Petry CJ, Sanz Marcos N, Pimentel G, Hayes MG, Nodzenski M, Scholtens DM, Hughes I A, Acerini CL, Ong KK, Lowe WL, Dunger DB. Associations between fetal imprinted genes and maternal blood pressure in pregnancy. Hypertension 2016;68:1459-66.
- Powlson AS, Challis BG, Halsall DJ, Schoenmakers E, Gurnell M. Nephrogenic syndrome of inappropriate antidiuresis secondary to an activating mutation in the arginine vasopressin receptor AVPR2. Clin Endocrinol (Oxf). 2016;85:306-12.
- Pozzilli P, Battelino T, Danne T, Hovorka R, Jarosz-Chobot P, Renard E. Continuous subcutaneous insulin infusion in diabetes: patient populations, safety, efficacy, and pharmacoeconomics. Diabetes Metab Res Rev. 2016;32:21-39. *
- Psichas A, Glass LL, Sharp SJ, Reimann F, Gribble FM. Galanin inhibits GLP-1 and GIP secretion via the GAL1 receptor in enteroendocrine L and K cells. Br J Pharmacol. 2016;173:888-98. *
- Raffan E, [19 authors], Yeo GS, O’Rahilly S. A deletion in the canine POMC Gene is associated with weight and appetite in obesity-prone Labrador Retriever dogs. Cell Metab. 2016;23:893-900. *
- Rahbari R, Wuster A, Lindsay SJ, Hardwick RJ, Alexandrov LB, Al Turki S, Dominiczak A, Morris A, Porteous D, Smith B, Stratton MR, UK10K Consortium, Hurles ME. Timing, rates and spectra of human germline mutation. Nat Genet. 2016;48:126-33. *
- Rey G, Valekunja UK, Feeney KA, Wulund L, Milev NB, Stangherlin A, Ansel-Bollepalli L, Velagapudi V, O’Neill JS, Reddy AB. The pentose phosphate pathway regulates the circadian clock. Cell Metab. 2016;24:462-73. *
- Richards P, Pais R, Habib AM, Brighton CA, Yeo GS, Reimann F, Gribble FM. High fat diet impairs the function of glucagon-like peptide-1 producing L-cells. Peptides 2016;77:21-7. *
- Rodriguez-Cuenca S, Whyte L, Hagen R, Vidal-Puig A, Fuller M. Stearoyl-CoA Desaturase 1 is a key determinant of membrane lipid composition in 3T3-L1 adipocytes. PLoS One 2016;11:e0162047. *
- Ronan L, Alexander-Bloch AF, Wagstyl K, Farooqi S, Brayne C, Tyler LK; Cam-CAN, Fletcher PC. Obesity associated with increased brain age from midlife. Neurobiol Aging. 2016;47:63-70. *
- Rowe ER, Mimmack ML, Barbosa AD, Haider A, Isaac I, Ouberai MM, Thiam AR, Patel S, Saudek V, Siniossoglou S, Savage DB. Conserved amphipathic helices mediate lipid droplet targeting of perilipins 1-3. J Biol Chem. 2016;291:6664-78. *
- Ruan Y, [12 authors], Hovorka R, AP@home Consortium. Variability of insulin requirements over 12 weeks of closed-loop insulin delivery in adults with type 1 diabetes. Diabetes Care 2016;39:830-2.
- Sandovici I, Hammerle CM, Cooper WN, Smith NH, Tarry-Adkins JL, Dunmore BJ, Bauer J, Andrews SR, Yeo GS, Ozanne SE, Constância M. Ageing is associated with molecular signatures of inflammation and type 2 diabetes in rat pancreatic islets. Diabetologia 2016;59:502-11. *
- Sanghez V, Cubuk C, Sebastian-Leon P, Carobbio S, Dopazo J, Vidal-Puig A, Bartolomucci A. Chronic subordination stress selectively downregulates the insulin signaling pathway in liver and skeletal muscle but not in adipose tissue of male mice. Stress 2016;19:214-24. *
- Santos DP, Kiskinis E, Eggan K, Merkle FT. Comprehensive protocols for CRISPR/Cas9-based gene editing in human pluripotent stem cells. Curr Protoc Stem Cell Biol. 2016;38:5B.6.1-5B.6.60. *
- Sayers SR, Reimann F, Gribble FM, Parker H, Zac-Varghese S, Bloom SR, Foretz M, Viollet B, Rutter GA. Proglucagon promoter Cre-mediated AMPK deletion in mice increases circulating GLP-1 levels and oral glucose tolerance. PLoS One 2016;11:e0149549. *
- Schoenmakers E, [14 authors; Farooqi S: 12], Chatterjee K. Mutation in human selenocysteine transfer RNA selectively disrupts selenoprotein synthesis. J Clin Invest. 2016;126:992-6. *
- Schooneman MG, Napolitano A, Houten SM, Ambler GK, Murgatroyd PR, Miller SR, Hollak CE, Tan CY, Virtue S, Vidal-Puig A, Nunez DJ, Soeters MR. Assessment of plasma acylcarnitines before and after weight loss in obese subjects. Arch Biochem Biophys. 2016;606:73-80.
- Scott RA, [148 authors; O’Rahilly S: 138], Waterworth DM. A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease. Sci Transl Med. 2016;8:341ra76. *
- Sefton C, Harno E, Davies A, Small H, Allen TJ, Wray JR, Lawrence CB, Coll AP, White A. Elevated hypothalamic glucocorticoid levels are associated with obesity and hyperphagia in male mice. Endocrinology 2016;157:4257-65. *
- Segarra N, Metastasio A, Ziauddeen H, Spencer J, Reinders NR, Dudas RB, Arrondo G, Robbins TW, Clark L, Fletcher PC, Murray GK. Abnormal frontostriatal activity during unexpected reward receipt in depression and schizophrenia: relationship to anhedonia. 2016;41:2001-10. *
- Sferruzzi-Perri AN, López-Tello J, Fowden AL, Constancia M. Maternal and fetal genomes interplay through phosphoinositol 3-kinase(PI3K)-p110α signaling to modify placental resource allocation. Proc Natl Acad Sci USA. 2016;113:11255-60. *
- Sleigh A, Lupson V, Thankamony A, Dunger DB, Savage DB, Carpenter TA, Kemp GJ. Simple and effective exercise design for assessing in vivo mitochondrial function in clinical applications using (31)P magnetic resonance spectroscopy. Sci Rep. 2016;6:19057. *
- Sleigh A, Savage DB, Williams GB, Porter D, Carpenter TA, Brindle KM, Kemp GJ. 31P magnetization transfer measurements of Pi→ATP flux in exercising human muscle. J Appl Physiol (1985). 2016;120:649-56. *
- Stewart S, Gessler F, Pluchino S, Moreau K. Inside-out: unpredicted Annexin A2 localisation on the surface of extracellular vesicles. Matters
- Stewart ZA, Wilinska ME, Hartnell S, Temple RC, Rayman G, Stanley KP, Simmons D, Law GR, Scott EM, Hovorka R, Murphy HR. Closed-loop insulin delivery during pregnancy in women with type 1 diabetes. N Engl J Med. 2016;375:644-54.
- Stewart ZA, Wilinska ME, Hartnell S, Temple RC, Rayman G, Stanley KP, Simmons D, Law GR, Scott EM, Hovorka R, Murphy HR. Closed-loop insulin delivery during pregnancy in women with type 1 diabetes. Obstetrical and Gynecological Survey 2016;71:699-701.
- Stijnen P, Ramos-Molina B, O’Rahilly S, Creemers JW. PCSK1 mutations and human endocrinopathies: from obesity to gastrointestinal disorders. Endocr Rev. 2016;37:347-71.
- Svendsen B, Pais R, Engelstoft MS, Milev NB, Richards P, Christiansen CB, Egerod KL, Jensen SM, Habib AM, Gribble FM, Schwartz TW, Reimann F, Holst JJ. GLP1- and GIP-producing cells rarely overlap and differ by bombesin receptor-2 expression and responsiveness. J Endocrinol. 2016;228:39-48.
- Tan CY, Virtue S, Murfitt S, Roberts LD, Phua YH, Dale M, Griffin JL, Tinahones F, Scherer PE, Vidal-Puig A. Erratum: Adipose tissue fatty acid chain length and mono-unsaturation increases with obesity and insulin resistance. Sci Rep. 2016;6:23873. *
- Tan HK, [8 authors], Evans ML, Shaw JA, Flanagan D. Low-blood glucose avoidance training improves glycemic variability in adults with type 1 diabetes complicated by impaired awareness of hypoglycemia: HypoCOMPaSS Trial. Diabetes Care 2016;39:e56-8.
- Tarry-Adkins JL, Fernandez-Twinn DS, Chen JH, Hargreaves IP, Neergheen V, Aiken CE, Ozanne SE. Poor maternal nutrition and accelerated postnatal growth induces an accelerated aging phenotype and oxidative stress in skeletal muscle of male rats. Dis Model Mech. 2016;9:1221-1229. *
- Tarry-Adkins JL, Fernandez-Twinn DS, Hargreaves IP, Neergheen V, Aiken CE, Martin-Gronert MS, McConnell JM, Ozanne SE. Coenzyme Q10 prevents hepatic fibrosis, inflammation, and oxidative stress in a male rat model of poor maternal nutrition and accelerated postnatal growth. Am J Clin Nutr. 2016;103:579-88. *
- Tauschmann M, Allen JM, Wilinska ME, Thabit H, Acerini CL, Dunger DB, Hovorka R. Home use of day-and-night hybrid closed-loop insulin delivery in suboptimally controlled adolescents with type 1 diabetes: a 3-week, free-living, randomized crossover trial. Diabetes Care 2016;39:2019-25.
- Tauschmann M, Allen JM, Wilinska ME, Thabit H, Stewart Z, Cheng P, Kollman C, Acerini CL, Dunger DB, Hovorka R. Day-and-night hybrid closed-loop insulin delivery in adolescents with type 1 diabetes: a free-living, randomized clinical trial. Diabetes Care 2016;39:1168-74.
- Thabit H, Bally L, Hovorka R. Available at a flash: a new way to check glucose. Lancet 2016;388:2213-4.
- Thabit H, Hartnell S, Allen JM, Lake A, Wilinska ME, Ruan Y, Evans ML, Coll AP, Hovorka R. Closed-loop insulin delivery in inpatients with type 2 diabetes: a randomised, parallel-group trial. Lancet Diabetes Endocrinol. 2016;pii: S2213-8587:30280-7.
- Thankamony A, Capalbo D, Jonsson PJ, Simpson HL, Dunger DB. Predictors of insulin-like growth factor-I responses to growth hormone replacement in young adults with growth hormone deficiency. Horm Res Paediatr. 2016;85:379-88.
- Thankamony A, Jensen RB, O’Connell SM, Day F, Kirk J, Donaldson M, Ivarsson SA, Söder O, Roche E, Hoey H, Ong KK, Dunger DB, Juul A. Adiposity in children born small for gestational age is associated with β-cell function, genetic variants for insulin resistance, and response to growth hormone treatment. J Clin Endocrinol Metab. 2016;101:131-42.
- Thiebaud N, Llewellyn-Smith IJ, Gribble F, Reimann F, Trapp S, Fadool DA. The incretin hormone glucagon-like peptide 1 increases mitral cell excitability by decreasing conductance of a voltage-dependent potassium channel. J Physiol. 2016;594:2607-28. *
- Tripolszki K, Knox R, Parker V, Semple R, Farkas K, Sulák A, Horváth E, Széll M, Nagy N. Somatic mosaicism of the PIK3CA gene identified in a Hungarian girl with macrodactyly and syndactyly. Eur J Med Genet. 2016;59:223-6.
- Van De Pette M, Tunster SJ, McNamara GI, Shelkovnikova T, Millership S, Benson L, Peirson S, Christian M, Vidal-Puig A, John RM. Cdkn1c boosts the development of brown adipose tissue in a murine model of Silver Russell Syndrome. PLoS Genet. 2016;12:e1005916. *
- van der Klaauw AA, Keogh JM, Henning E, Stephenson C, Kelway S, Trowse VM, Subramanian N, O’Rahilly S, Fletcher PC, Farooqi IS. Divergent effects of central melanocortin signalling on fat and sucrose preference in humans. Nat Commun. 2016;7:13055. *
- Vinckier F, Gaillard R, Palminteri S, Rigoux L, Salvador A, Fornito A, Adapa R, Krebs MO, Pessiglione M, Fletcher PC. Confidence and psychosis: a neuro-computational account of contingency learning disruption by NMDA blockade. Mol Psychiatry. 2016;21:946-55.
- Wang H, [19 authors, Savage DB: 8], Farese RV. Seipin is required for converting nascent to mature lipid droplets. Elife 2016;5. *
- Yavari A, [52 authors; Yeo GS: 43], Ashrafian H. Chronic activation of γ2 AMPK induces obesity and reduces β cell function. Cell Metab. 2016;23:821-36. *
- Yew Tan C, Virtue S, Murfitt S, Roberts LD, Phua YH, Dale M, Griffin JL, Tinahones F, Scherer PE, Vidal-Puig A. Adipose tissue fatty acid chain length and mono-unsaturation increases with obesity and insulin resistance. Sci Rep. 2015;5:18366. Erratum in: Sci Rep. 2016;6:23873. *
- Zhou J, Lam B, Neogi SG, Yeo GS, Azizan EA, Brown MJ. Transcriptome pathway analysis of pathological and physiological aldosterone-producing human tissues. Hypertension 2016;68:1424-31. *
- Ziauddeen H, Garcia-Rizo C, Bernardo M, Kirkpatrick B, Ozanne SE, Jones PB, Fernandez-Egea E. Association of birth weight and the development of antipsychotic induced adiposity in individuals with treatment resistant schizophrenia. Eur Neuropsychopharmacol. 2016;26:972-8.
- Ziauddeen H, [15 authors], Fletcher PC, Bullmore ET. Opioid antagonists and the A118G polymorphism in the μ-opioid receptor gene: effects of GSK1521498 and naltrexone in healthy drinkers stratified by OPRM1 genotype. 2016;41:2647-57. *