Publications - Wellcome-MRC Institute of Metabolic Science

Primary Research Publications

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2021

Artero-Castro A, Long K, Bassett A, Avila-Fernandez A, Corton M, Vidal-Puig A, Jendelova P, Rodriguez-Jimenez FJ, Clemente E, Ayuso C, Slaven E, Gene Correction Recovers Phagocytosis in Retinal Pigment Epithelium Derived from Retinitis Pigmentosa-Human-Induced Pluripotent Stem Cells. Int J Mol Sci. 2021 Feb 20;22(4):2092. doi: 10.3390/ijms22042092. PMID:33672445 PMCID:PMC7923278
Azzu V, Vacca M, Kamzolas I, Hall Z, Leslie J, Carobbio S, Virtue S, Virtue S, Davies SE, Lukasik A, Dale M, Bohlooly-Y M, Acharjee A, Linden D, Bidault G, Petsalaki E, Griffin JL, Oakley F, Allison ME, Vidal-Puig A. Suppression of insulin-induced gene 1 (INSIG1) function promotes hepatic lipid remodelling and restrains NASH progression. Mol Metab. 2021 Mar 12:101210. doi: 10.1016/jmolmet.2021.101210. PMID:33722690
Beardsall K, Thomason L, Guy C, Iglesias-Platas I, van Weissenbruch MM, Bond S, Allison A, Kim S, Petrou S, Pantaleo B, Hovorka R, Dunger D; REACT collaborative. Real-time continuous glucose monitoring in preterm infants (REACT): an international, open-label, randomised controlled trial. Lancet Child Adolesc Health. 2021 Feb 9:S2352-4642(20)30367-9. doi: 10.1016/S2352(20)30367-9. PMID:33577770
Boughton CK, Daly A, Thabit H, Hartnell S, Herzig D, Vogt A, Ruan Y, Wilinska ME, Evans ML, Coll AP, Bally L, Hovorka R. Day-to-day variability of insulin requirements in the inpatient setting: observations during fully closed-loop insulin delivery. Diabetes Obes Metab. 2021 Apr 6. doi: 10.1111/dom.14396. PMID33822461
Boughton CK, Hartnell S, Thabit H, Poettler T, Herzig D, Wilinska ME, Ashcroft NL, Sibayan J, Cohen N, Calhoun P, Bally L, Mader JK, Evans M, Leelarathna L, Hovorka R. Hybrid closed-loop glucose control with faster insulin aspart (Fiasp) compared with standard insulin aspart in adults with type 1 diabetes: a double-blind, multicentre, multinational, randomised, crossover study. Diabetes Obes Metab. 2021 Feb 19. doi:10.1111/dom.14355. PMID:33606901
Boughton CK, Hovorka R. Correction to: New closed-loop insulin systems. Diabetologia. 2021 Mar 22. doi: 10.1007/s00125-021-05443-1. PMID:33751132
Boughton CK, Hovorka R. Can exenatide flatten the post-prandial glucose curve in type 1 diabetes? Ann Transl Med. 2020 Nov;8(22):1535. doi: 10.21037/atm-20-3654. PMID:33313280 PMCID:PMC7729374
Boughton CK, Hovorka R. New closed-loop insulin systems. Diabetologia. 2021 Feb 6. doi: 10.1007/s00125-021-05391-w. PMID:33550442
Brierley DI, Holt MK, Singh A, de Araujo A, McDougle M, Vergara M, Afaghani MH, Lee SJ, Scott K, Maske C, Langhans W, Krause E, de Kloet A, Gribble FM, Reimann F, Rinaman L, de Lartigue G, Trapp S. Central and peripheral GLP-1 systems independently suppress eating. Nat Metab. 2021 Feb;3(2):258-273. doi: 10.1038/s42255-021-00344-4. PMID: 33589843 PMCID:PMC7116821
Brouwers B, Mendes de Oliveira E, Marti-Solano M, Monteiro FBF, Laurin SA, Keogh JM, Henning E, Bounds R, Daly CA, Houston S, Ayinampudi V, Wasiluk N, Clarke D, Plouffe B, Bouvier M, Babu MM, Farooqi IS, Mokrosiński J. Human MC4R variants affect endocytosis, traffickingand dimerization revealing multiple cellularmechanisms involved in weight regulation. Cell Reports, 23 March 2021, 34, 108862. PMID: 33761344 PMCID:PMC7994375
Burke LK, Darwish T, Cavanaugh AR, Virtue S, Roth E, Morro J, Liu SM, Xia J, Dalley JW, Burling K, Chua S, Vidal-Puig T, Schwartz GJ, Blouet C. mTORC1 in AGRP neurons integrates exteroceptive and interoceptive food-related cues in the modulation of adaptive energy expenditure in mice. Elife. 2017 May 23;6:e22848. doi: 10.7554/eLife.22848. PMID:28532548 PMCID:PMC5441868
Camm EJ, Cross CM, Kane AD, Tarry-Adkins JL, Ozanne SE, Giussani DA. Maternal antioxidant treatment protects adult offspring against memory loss and hippocampal atrophy in a rodent model of developmental hypoxia. FASEB J. 2021 May;35(5):e21477. doi: 10.1096/fj.202002557RR. PMID:33891326
Carobbio S, Guenantin AC, Bahri M, Rodriguez-Fdez S, Hong F Kamzolas I, Samuelson I, Lond K, Awad S, Lukovic D, Erceg S, Bassett A, Mendjan S, Vallier L, Rosen BS, Chiarugi D, Vidal-Puig A. Unravelling the development roadmap towards human brown adipose tissue. Stem Cell Reports. 2021 Feb 6;S2213 6711(21)00043-6. doi: 10.1016/j.stemcr.2021.01.013. PMID:33606988 PMCID:PMC7940445
Choi RJ, Mohamad Zobir SZ, Alexander-Dann B, Sharma N, Ma MKL, Lam BYH, Yeo GSH, Zhang W, Fan TP, Bender A. Combination of Ginsenosides Rb2 and Rg3 Promotes Angiogenic Phenotype of Human Endothelial Cells via PI3K/Akt and MAPK/ERK Pathways. Front Pharmacol. 2021 Feb 10;12:618773. doi: 10.3389/fphar.2021.618773. PMID:33643049 PMCID:PMC7902932
Di Cicco E, Moran C, Visser WE, Nappi A, Schoenmakers E, Todd P, Lyons G, Dattani M, Ambrosio R, Parisi S, Salvatore D, Chatterjee VK, Dentice M. Germline mutations in the thyroid hormone receptor alpha gene predispose to cutaneous tags and melanocytic nevi. Thyroid. 2021 Jan 28. doi: 10.1089/thy.2020.0391. PMID:33509032
Fabricius TW, Verhulst CEM, Kristensen PL, Tack CJ, McCrimmon RJ, Heller S, Evans ML, Amiel SA, Pieber TR, de Galan BE, Pedersen-Bjergaard U; Hypo-RESOLVE consortium. Hyperinsulinaemic-hypoglycaemic glucose clamps in human research: a systematic review of the literature. Diabetologia. 2021 Feb 10. doi: 10.1007/s00125-020-05361-8. PMID:33566134
Finnemann JJS, Plaisted-Grant K, Moore J, Teufel C, Fletcher PC. Low-level, prediction-based sensory and motor processes are unimpaired in Autism. Neuropsychologia. 2021 Mar 29;156:107835. doi: 10.1016/j.neuropsychologia.2021.107835. PMID:33794277
Fuchs J, Allen JM, Boughton CK, Wilinska ME, Thankamony A, de Beaufort C, Campbell F, Yong J, Froehlich-Reiterer E, Mader JK, Hofer SE, Kapellen TM, Rami-Merhar B, Tauschmann M, Hood K, Kimbell B, Lawton J, Roze S, Sibayan J, Cohen N, Hovorka R; KidsAP Consortium. Assessing the efficacy, safety and utility of closed-loop insulin delivery compared with sensor-augmented pump therapy in very young children with type 1 diabetes (KidsAP02 study): an open-label, multicentre, multinational, randomised cross-over study protocol. BMJ Open. 2021 Feb 12;11(2):e042790. doi: 10.1136/bmjopen-2020-042790. PMID: 33579766 PMC7883854
Furse S, Watkins AJ, Hojat N, Smith J, Williams HEL, Chiarugi D, Koulman A. Lipid Traffic Analysis reveals the impact of high paternal carbohydrate intake on offsprings’ lipid metabolism. Commun Biol. 2021 Feb 5;4(1):163. doi: 10.1038/s42003-021-01686-1. PMID:33547386 PMCID:PMC7864968
Galvin SG, Larraufie P, Kay RG, Pitt H, Bernard E, McGavigan AK, Brandt H, Hood J, Sheldrake L, Conder S, Atherton-Kemp D, Lu VB, O’Flaherty EAA, Roberts GP, Ämmälä C, Jermutus L, Baker D, Gribble FM, Reimann F. Peptidomics of enteroendocrine cells and characterisation of potential effects of a novel preprogastrin derived-peptide on glucose tolerance in lean mice. Peptides. 2021 Mar 17:170532. doi: 10.1016/j.peptides.2021.170532. PMID:33744371
Gillett D, Marsden D, Ballout S, Attili B, Bird N, Heard S, Gurnell M, Mendichovszky IA, Aloj L. 3D printing 18 F radioactive phantoms for PET imaging. EJNMMI Phys. 2021 Apr 28;8(1):38. doi: 10.1186/s40658-021-00383-6. PMID:33909154
Gribble FM, O’Rahilly S. Obesity therapeutics: The end of the beginning. Cell Metab 2021;33:705-706. doi: 10.1016/j.cmet.2021.03.012. PMID:33826913
Gribble FM, Reimann F. Metabolic Messengers: glucagon-like peptide 1. Nat Metab. 2021 Feb;3(2):142-148. doi: 10.1038/s42255-020-00327-x. PMID: 33432200
Gurnell M, Heaney LG, Price D, Menzies-Gow A. Long-term corticosteroid use, adrenal insufficiency, and the need for steroid-sparing treatment in adult severe asthma. J Intern Med. 2021 Feb 17. doi: 10.1111/joim.13273. PMID:33598993
Hamed MO, Barlow AD, Dolezalova N, Khosla S, Sagar A, Gribble FM, Davies S, Murphy MP, Hosgood SA, Nicholson ML, Saeb-Parsy K. Ex vivo normothermic perfusion of isolated segmental porcine bowel: a novel functional model of the small intestine. BJS Open. 2021 Mar 5;5(2):zrab009. doi: 10.1093/bjsopen/zrab009. PMID:33839750 PMCID:PMC8038264
Heeley N, Kirwan P, Darwish T, Arnaud M, Evans ML, Merkle FT, Reimann F, Gribble FM, Blouet C. Rapid sensing of l-leucine by human and murine hypothalamic neurons: Neurochemical and mechanistic insights. Mol Metab. 2018 Apr;10:14-27. doi: 10.1016/j.molmet.2018.01.021. PMID29439854 PMCID:PMC5985239
Ho K, Fleseriu M, Kaiser U, Salvatori R, Brue T, Lopes MB, Kunz P, Molitch M, Camper SA, Gadelha M, Syro LV, Laws E, Reincke M, Nishioka H, Grossman A, Barkan A, Casanueva F, Wass J, Mamelak A, Katznelson L, van der Lely AJ, Radovick S, Bidlingmaier M, Boguszewski M, Bollerslev J, Hoffman AR, Oyesiku N, Raverot G, Ben-Shlomo A, Fowkes R, Shimon I, Fukuoka H, Pereira AM, Greenman Y, Heaney AP, Gurnell M, Johannsson G, Osamura RY, Buchfelder M, Zatelli MC, Korbonits M, Chanson P, Biermasz N, Clemmons DR, Karavitaki N, Bronstein MD, Trainer P, Melmed S. Pituitary Neoplasm Nomenclature Workshop: Does Adenoma Stand the Test of Time? J Endocr Soc. 2021 Feb 9;5(3):bvaa205. doi: 10.1210/jendso/bvaa205. PMID:33604494 PMCID:PMC7874572
Hornigold DC, Roth E, Howard V, Will S, Oldham S, Coghlan MP, Blouet C, Trevaskis JL. A GLP-1:CCK fusion peptide harnesses the synergistic effects on metabolism of CCK-1 and GLP-1 receptor agonism in mice. Appetite. 2018 Aug 1;127:334-340. doi: 10.1016/j.appet.2018.05.131. PMID:29782892 PMCID:PMC6026274
Huang-Doran I, Kinzer AB, Jimenez-Linan M, Thackray K, Harris J, Adams CL, de Kerdanet M, Stears A, O’Rahilly S, Savage DB, Gorden P, Brown RJ, Semple RK. Ovarian hyperandrogenism and its response to gonadotropin-releasing hormone analogue therapy in primary severe insulin resistance. J Clin Endocrinol Metab. 2021 Apr 26:dgab275. doi: 10.1210/clinem/dgab275. PMID:33901270
Huang LO, Rauch A, Mazzaferro E, Preuss M, Carobbio S, Bayrak CS, Chami N, Wang Z, Schick UM, Yang N, Itan Y, Vidal-Puig A, den Hoed M, Mandrup S, Kilpeläinen TO, Loos RJF. Genome-wide discovery of genetic loci that uncouple excess adiposity from its comorbidities. Nat Metab. 2021 Feb;3(2):228-243. doi: 10.1038/s42255-021-00346-2. PMID:33619380
Jerber J, Seaton DD, Cuomo ASE, Kumasaka N, Haldane J, Steer J, Patel M, Pearce D, Andersson M, Bonder MJ, Mountjoy E, Ghoussaini M, Lancaster MA; HipSci Consortium, Marioni JC, Merkle FT, Gaffney DJ, Stegle O. Population-scale single-cell RNA-seq profiling across dopaminergic neuron differentiation. Nat Genet. 2021 Mar;53(3):304-312. doi: 10.1038/s41588-021-00801-6. PMID:33664506
Kelly MP, Brayne C, Kinmonth AL, Kriznik N, Ford J, Fletcher PC. Inequalities in mental health: predictive processing and social life. Curr Opin Psychiatry. 2021 Mar 1;34(2):171-176. doi: 10.1097/YCO.0000000000000680. PMID:33394729
Kimbell B, Lawton J, Boughton C, Hovorka R, Rankin D. Parents’ experiences of caring for a young child with type 1 diabetes: a systematic review and synthesis of qualitative evidence. BMC Pediatr. 2021 Apr 4;21(1):160. doi: 10.1186/s12887-021-02569-4. PMID:33814007 PMCID:PMC8019496
Lafferty RA, Tanday N, Moffett RC, Reimann F, Gribble FM, Flatt PR, Irwin N. Positive Effects of NPY1 Receptor Activation on Islet Structure Are Driven by Pancreatic Alpha- and Beta-Cell Transdifferentiation in Diabetic Mice. Front Endocrinol (Lausanne). 2021 Feb 25;12:633625. doi: 10.3389/fendo.2021.633625. PMID:33716983 PMCID:PMC7949013
Lawton J, Hart R, Kimbell B, Allen JM, Besser REJ, Boughton C, Elleri D, Fuchs J, Ghatak A, Randell T, Thankamony A, Trevelyan N, Hovorka R, Rankin D. Data sharing whilst using a closed-loop system: Qualitative study of adolescents’ and parents’ experiences and views. Diabetes Technol Ther. 2021 Feb 19. doi: 10.1089/dia.2020.0637. PMID:33605790
Leelarathna L, Thabit H, Wilinska ME, Bally L, Mader JK, Pieber TR, Benesch C, Arnolds S, Johnson T, Heinemann L, Hermanns N, Evans ML, Hovorka R. Evaluating Glucose Control With a Novel Composite Continuous Glucose Monitoring Index. J Diabetes Sci Technol. 2020 Mar;14(2):277-283. doi: 10.1177/1932296819838525. PMID: 30931606 PMCID:PMC7196869
Li J, Zhang Y, Ye Y, Li D, Liu Y, Lee E, Zhang M, Dai X, Zhang X, Wang S, Zhang J, Jia W, Zen K, Vidal-Puig A, Jiang X, Zhang CY. Pancreatic β cells control glucose homeostasis via the secretion of exosomal miR-29 family. J Extracell Vesicles. 2021 Jan;10(3):e12055. doi: 10.1002/jev2.12055. PMID:33520119 PMCID:PMC7820156
Liu S, Marcelin G, Blouet C, Jeong JH, Jo YH, Schwartz GJ, Chua S Jr. A gut-brain axis regulating glucose metabolism mediated by bile acids and competitive fibroblast growth factor actions at the hypothalamus. Mol Metab. 2018 Feb;8:37-50. doi: 10.1016/j.molmet.2017.12.003. PMID:29290621 PMCID:PMC5985052
Lockhart SM, O’Rahilly S. Colchicine-an old dog with new tricks. Nat Metab 2021 doi:10.1038/s42255-021-00360-4.PMID: 33846642
Lotta L, Langenberg C, Wareham NJ, Farooqi IS. Reply to Unreliability of genotyping arrays for detecting very rare variants in human genetic studies: Example from a recent study of MC4R. Cell. 2021 Apr 1;184(7):1652-1653. doi: 10.1016/j.cell.2021.03.014. PMID:33798435
Lotta LA, Pietzner M, Stewart ID, Wittemans LBL, Li C, Bonelli R, Raffler J, Biggs EK, Oliver-Williams C, Auyeung VPW, Luan J, Wheeler E, Paige E, Surendran P, Michelotti GA, Scott RA, Burgess S, Zuber V, Sanderson E, Koulman A, Imamura F, Forouhi NG, Khaw KT; MacTel Consortium, Griffin JL, Wood AM, Kastenmüller G, Danesh J, Butterworth AS, Gribble FM, Reimann F, Bahlo M, Fauman E, Wareham NJ, Langenberg C. A cross-platform approach identifies genetic regulators of human metabolism and health. Nat Genet. 2021 Jan;53(1):54-64. doi: 10.1038/s41588-020-00751-5. Epub 2021 Jan 7. PMID: 33414548.
Lu VB, Gribble FM, Reimann F. Nutrient-Induced Cellular Mechanisms of Gut Hormone Secretion. Nutrients. 2021 Mar 9;13(3):883. doi: 10.3390/nu13030883. PMID:33803183 PMCID:PMC8000029
Moore SE, Doel AM, Ong KK, Dunger DB, Affara NA, Prentice AM, Bernstein RM; HERO-G Working Group. Identification of nutritionally modifiable hormonal and epigenetic drivers of positive and negative growth deviance in rural African fetuses and infants: Project protocol and cohort description. Gates Open Res. 2020 Feb 24;4:25. doi: 10.12688/gatesopenres.13101.1. PMID:33693312 PMCID:PMC7921526
Moran C, McEniery CM, Schoenmakers N, Mitchell C, Sleigh A, Watson L, Lyons G, Burling K, Barker P, Chatterjee K. Dyslipidemia, insulin resistance, ectopic lipid accumulation and vascular function in Resistance to Thyroid Hormone β. J Clin Endocrinol Metab. 2021 Feb 1:dgab002. doi: 10.1210/clinem/dgab002. PMID:33524107
Muzurović E, van der Lely AJ, Gurnell M. AST to ALT Ratio and Peripheral Arterial Disease in a Hypertensive Population-Is There a Link? Angiology. 2021 Mar 24:33197211004387. doi: 10.1177/00033197211004387. PMID:33759592
Naumenko DJ, Dykes J, O’Connor GK, Stanley Z, Affara N, Doel AM, Drammeh S, Dunger DB, Faal A, Ong KK, Sosseh F, Prentice AM, Moore SE, Bernstein RM. A Novel method for the identification and quantification of weight faltering. Am J Phys Anthropol. 2021 Jan 1. doi: 10.1002/ajpa.24217. PMID:33386624
Olga L, van Diepen JA, Bobeldijk-Pastorova I, Gross G, Prentice PM, Snowden SG, Furse S, Kooistra T, Hughes IA, Schoemaker MH, van Tol EAF, van Duyvenvoorde W, Wielinga PY, Ong KK, Dunger DB, Kleemann R, Koulman A. Lipid ratios representing SCD1, FADS1, and FADS2 activities as candidate biomarkers of early growth and adiposity. EBioMedicine. 2021 Jan 6;63:103198. doi: 10.1016/j.ebiom.2020.103198. Epub ahead of print. PMID: 33421943; PMCID: PMC7806876.
O’Rahilly S. The islet’s bridesmaid becomes the bride: Proglucagon-derived peptides deliver transformative therapies. Cell 2021:S0092-8674(21)00304-4. doi:10.1016/j.cell.2021.03.019. PMID:33831374
O’Rahilly S. “Treasure Your Exceptions”-Studying Human Extreme Phenotypes to Illuminate Metabolic Health and Disease: The 2019 Banting Medal for Scientific Achievement Lecture. Diabetes. 2021 Jan;70(1):29-38. doi: 10.2337/dbi19-0037. PMID:33355307 PMCID:PMC7881844
Pérez-Sánchez C, Barbarroja N, Pantaleão LC, López-Sánchez LM, Ozanne SE, Jurado-Gámez B, Aranda E, Lopez-Pedrera C, Rodríguez-Ariza A. Clinical Utility of microRNAs in Exhaled Breath Condensate as Biomarkers for Lung Cancer. Pers Med. 2021 Feb 9;11(2):111. doi: 10.3390/jpm11020111. PMID:33572343
Petkevicius K, Bidault G, Virtue S, Jenkins B, van Dierendonck XAMH, Dugourd A, Saez-Rodriguez J, Stienstra R, Koulman A, Vidal-Puig A. Norepinephrine promotes triglyceride storage in macrophages via beta2-adrenergic receptor activation. FASEB J. 2021 Feb;35(2):e21266. doi: 10.1096/fj.202001101R. PMID: 33484195.
Petkevicius K, Bidault G, Virtue S, Newland SA, Dale M, Dugourd A, Saez-Rodriguez J, Mallat Z, Vidal-Puig A. Macrophage beta2-adrenergic receptor is dispensable for the adipose tissue inflammation and function. Molecular Metabolism. 2021 Mar 25;48:101220. doi: 10.1016/j.molmet.2021.101220. PMID: 33774223
Petry CJ, Burling KA, Barker P, Hughes IA, Ong KK, Dunger DB. Pregnancy Serum DLK1 Concentrations are associated with Indices of Insulin Resistance and Secretion. J Clin Endo Metab. 2021 Feb 26;dgab123. doi: 10.1210/clinem/dgab123. PMID:33640968
Quarta C, Claret M, Zeltser LM, Williams KW, Yeo GSH, Tschöp MH, Diano S, Brüning JC, Cota D. POMC neuronal heterogeneity in energy balance and beyond: an integrated view. Nat Metab. 2021 Feb 25. doi: 10.1038/s42255-021-00345-3. PMID:33633406
Quilter CR, Harvey KM, Bauer J, Skinner BM, Gomez M, Shrivastava M, Doel AM, Drammeh S, Dunger DB, Moore SE, Ong KK, Prentice AM, Bernstein RM, Sargent CA, Affara NA. Identification of methylation changes associated with positive and negative growth deviance in Gambian infants using a targeted methyl sequencing approach of genomic DNA. FASEB Bioadv. 2021 Feb 5;3(4):205-230. doi: 10.1096/fba.2020-00101. PMID:33842847. PMCID:PMC8019263
Rankin D, Kimbell B, Hovorka R, Lawton J. Adolescents’ and their parents’ experiences of using a closed-loop system to manage type 1 diabetes in everyday life: qualitative study. Chronic Illn. 2021 Jan 20:1742395320985924. doi: 10.1177/1742395320985924. PMID:33472409
Robertson TM, Brown JE, Fielding BA, Hovorka R, Robertson MD. Resistant Starch Production and Glucose Release from Pre-Prepared Chilled Food: The SPUD Project. Nutr Bull. 2021 Mar;46(1):52-59. doi: 10.1111/nbu.12476. PMID:33776583 PMCID:PMC7984060
Romero-Picó A, Sanchez-Rebordelo E, Imbernon M, González-Touceda D, Folgueira C, Senra A, Fernø J, Blouet C, Cabrera R, van Gestel M, Adan RA, López M, Maldonado R, Nogueiras R, Diéguez C. Melanin-Concentrating Hormone acts through hypothalamic kappa opioid system and p70S6K to stimulate acute food intake. Neuropharmacology. 2018 Mar 1;130:62-70. doi: 10.1016/j.neuropharm.2017.11.040. PMID:29191753
Sam AH, Reid MD, Thakerar V, Gurnell M, Westacott R, Yeates P, Reed MWR, Brown CA. The influence of candidates’ physical attributes on assessors’ ratings in clinical practice. Med Teach. 2021 Feb 11:1-6. doi: 10.1080/0142159X.2021.1877268. PMID:33569973
Sanchez-Delgado G, Martinez-Tellez B, Acosta FM, Virtue S, Vidal-Puig A, Gil A, Llamas-Elvira JM, Ruiz JR. Brown Adipose Tissue Volume and Fat Content are Positively Associated with Whole-Body Adiposity in Young Men, Not in Women. Diabetes. 2021 Apr 15:db210011. doi: 10.2337/db21-0011. PMID:33858825
Sandovici I, Hammerle CM, Virtue S, Vivas-Garcia Y, Izquierdo-Lahuerta A, Ozanne SE, Vidal-Puig A, Medina-Gómez G & Constância M. Autocrine IGF2 programmes β-cell plasticity under conditions of increased metabolic demand. Scientific Reports. 2021 Apr 8;11(1):7717. doi: 10.1038/s41598-021-87292-x. PMID:33833312 PMCID:PMC8032793
Spiroski AM, Niu Y, Nicholas LM, Austin-Williams S, Camm EJ, Sutherland MR, Ashmore TJ, Skeffington KL, Logan A, Ozanne SE, Murphy MP, Giussani DA. Mitochondria antioxidant protection against cardiovascular dysfunction programmed by early-onset gestational hypoxia. FASEB J. 2021 May;35(5):e21446. doi: 10.1096/fj.202002705R. PMID:33788974
Stern E, Schoenmakers N, Nicholas AK, Kassif E, Hamiel OP, Yeshayahu Y. A Novel mutation in the Thyroglobulin Gene resulting in Neonatal Goiter and Congenital Hypothyroidism in an Eritrean infant. J Clin Res Pediatr Endocrinol. 2021 Apr 9. doi: 10.4274/jcrpe.galenos.2021.2020.0278. PMID:33832185
Vickneson K, Blackburn J, Gallagher JR, Evans ML, de Galan BE, Pedersen-Bjergaard U, Thorens B, McNeilly AD, McCrimmon RJ. Cold-induced dishabituation in rodents exposed to recurrent hypoglycaemia. Diabetologia. 2021 Mar 17. doi: 10.1007/s00125-021-05425-3. PMID:33730186
Ward DL, Schroeder L, Pomeroy E, Roy JE, Buck LT, Stock JT, Martin-Gronert M, Ozanne SE, Silcox MT, Viola TB. Early life malnutrition and fluctuating asymmetry in the rat bony labyrinth. Anat Rec (Hoboken). 2021 Feb 15. doi: 10.1002/ar.24601. PMID:33586866
Westwater ML, Mancini F, Gorka AX, Shapleske J, Serfontein J, Grillon C, Ernst M, Ziauddeen H, Fletcher PC. Prefrontal responses during proactive and reactive inhibition are differentially impacted by stress in anorexia and bulimia nervosa. J Neurosci. 2021 Apr 12:JN-RM-2853-20. doi: 10.1523/JNEUROSCI.2853-20.2021. PMID:33846229
Yang M, Darwish T, Larraufie P, Rimmington D, Cimino I, Goldspink DA, Jenkins B, Koulman A, Brighton CA, Ma M, Lam BYH, Coll AP, O’Rahilly S, Reimann F, Gribble FM. Inhibition of mitochondrial function by metformin increases glucose uptake, glycolysis and GDF-15 release from intestinal cells. Sci Rep. 2021 Jan 28;11(1):2529. doi: 10.1038/s41598-021-81349-7. PMID:33510216 PMCID:PMC7843649
Yang M, Reimann F, Gribble FM. Chemosensing in enteroendocrine cells: mechanisms and therapeutic opportunities. Curr Opin Endocrinol Diabetes Obes. 2021 Apr 1;28(2):222-231. doi: 10.1097/MED.0000000000000614. PMID:33449572
Yeo GSH, Moro Chao DH, Siegert AM, Koerperich ZM, Ericson MD, Simonds SE, Larson CM, Luquet S, Clarke I, Sharma S, Clément K, Cowley MA, Haskell-Luevano C, Van Der Ploeg L, Adan RAH. The melanocortin pathway and energy homeostasis: From discovery to obesity therapy. Mol Metab. 2021 Mar 5:101206. doi: 10.1016/j.molmet.2021.101206. PMID:33684608

2020

Alligier M, Barrès R, Blaak EE, Boirie Y, Bouwman J, Brunault P, Campbell K, Clément K, Farooqi IS, Farpour-Lambert NJ, Frühbeck G, Goossens GH, Hager J, Halford JCG, Hauner H, Jacobi D, Julia C, Langin D, Natali A, Neovius M, Oppert JM, Pagotto U, Palmeira AL, Roche H, Rydén M, Scheen AJ, Simon C, Sorensen TIA,Tappy L, Yki-Järvinen H, Ziegler O, Laville M. OBEDIS Core Variables roject: European Expert Guidelines on a Minimal Core Set of Variables to Include in Randomized, Controlled Clinical Trials of Obesity Interventions. Obes Facts. 2020 Jan 13:1-28. Epub ahead of print. PubMed PMID: 31945762. PMCID: PMC7098277.
Anstee QM, Darlay R, Cockell S, Meroni M, Govaere O, Tiniakos D, Burt AD, Bedossa P, Palmer J, Liu YL, Aithal GP, Allison M, Yki-Järvinen H, Vacca M, Dufour JF, Invernizzi P, Prati D, Ekstedt M, Kechagias S, Francque S, Petta S, Bugianesi E, Clement K, Ratziu V, Schattenberg JM, Valenti L, Day CP, Cordell HJ, Daly AK; EPoS Consortium Investigators. Genome-wide Association Study of Non-Alcoholic Fatty Liver and Steatohepatitis in a Histologically-Characterised Cohort. Journal of Hepatology. 2020 Apr 13:S0168-8278(20)30213-0. PMID: 32298765.
Araiz C, Yan A, Bettedi L, Samuelson I, Virtue S, McGavigan AK, Dani C, Vidal-Puig A, Foukas LC. Publisher Correction: Enhanced β-Adrenergic Signalling Underlies an Age-Dependent Beneficial Metabolic Effect of PI3K p110α Inactivation in Adipose Tissue. Nat Commun. 2020 Feb 21;11(1):1078. PMID: 32081871.
Ast J, Arvaniti A, Fine NHF, Nasteska D, Ashford FB, Stamataki Z, Koszegi Z, Bacon A, Jones BJ, Lucey MA, Sasaki S, Brierley DI, Hastoy B, Tomas A, D’Agostino G, Reimann F, Lynn FC, Reissaus CA, Linnemann AK, D’Este E, Calebiro D, Trapp S, Johnsson K, Podewin T, Broichha- gen J, Hodson DJ. Author Correction: Super-resolution microscopy compatible fluorescent probes reveal endogenous glucagon-like peptide-1 receptor distribution and dynamics. Nat Commun. 2020 Oct 9;11(1):5160. PMID: 33037231.
Azzu V, Vacca M, Virtue S, Allison M, Vidal-Puig A. Adipose tissue-liver cross talk in the control of whole-body metabolism: implications in non-alcoholic fatty liver disease. Gastroenterology. 2020 Feb 12. pii: S0016-5085(20)30224-9. Epub ahead of print. PMID: 32061598.
Baig S, Shabeer M, Parvaresh Rizi E, Agarwal M, Lee MH, Ooi DSQ, Chia C, Aung N, Ng G, Teo Y, Chhay V, Magkos F, Vidal-Puig A, Seet RCS, Toh SA. Heredity of type 2 diabetes confers increased susceptibility to oxidative stress and inflammation. BMJ Open Diabetes Res Care. 2020 Jan;8(1). PMID: 32049633. PMCID: PMC7039582.
Banholzer N, Herzig D, Piazza C, Álvarez-Martínez M, Nakas CT, Kosinski C, Feuerriegel S, Hovorka R, Bally L. Effect of nutrition on postprandial glucose control in hospitalized patients with type 2 diabetes receiving fully automated closed-loop insulin therapy. Diabetes Obes Metab. 2020 Sep 4. PMID: 32885596.
Bashari WA, Senanayake R, Koulouri O, Gillett D, MacFarlane J, Powlson AS, FernandezPombo A, Bano G, Martin AJ, Scoffings D, Cheow H, Mendichovszky I, Tysome J, Donnelly N, Santarius T, Kolias A, Mannion R, Gurnell M. PET-guided Repeat Transsphenoidal Surgery for Previously Deemed Unresectable Lateral Disease in Acromegaly. Neurosurgical Focus. 2020 Jun;48(6):E8. PMID: 32480379.
Bernstein RM, O’Connor GK, Vance EA, Affara N, Drammeh S, Dunger DB, Faal A, Ong KK, Sosseh F, Prentice AM, Moore SE. Timing of the Infancy-Childhood Growth Transition in Rural Gambia. Frontiers of Endocrinology (Lausanne). 2020 Mar 24;11:142. PMID: 32265838 PMCID: PMC7105771.
Blackwell AKM, De-Loyde K, Brocklebank LA, Maynard OM, Marteau TM, Hollands GJ, Fletcher PC, Attwood AS, Morris RW, Munafò MR. Tobacco and electronic cigarette cues for smoking and vaping: an online experimental study. BMC Res Notes. 2020 Jan 15;13(1):32. PubMed PMID:31941548; PubMed Central PMCID: PMC6964108.
Blackwell AKM, De-Loyde K, Hollands GJ, Morris RW, Brocklebank LA, Maynard OM, Fletcher PC, Marteau TM, Munafò MR. The Impact on Selection of Non-Alcoholic vs Alcoholic Drink Availability: An Online Experiment. BMC Public Health. 2020 May 6;20(1):526. PMID: 32370760 PMCID: PMC7201696.
Blastland M, Freeman ALJ, van der Linden S, Marteau TM, Spiegelhalter D. Five rules for evidence communication. Nature. 2020 Nov;587(7834):362-364. doi: 10.1038/d41586-020-03189-1. PMID: 33208954.
Boughton C, Allen JM, Tauschmann M, Hartnell S, Wilinska ME, Musolino G, Acerini CL, Dunger PD, Campbell F, Ghatak A, Randell T, Besser R, Trevelyan N, Elleri D, Northam E, Hood K, Scott E, Lawton J, Roze S, Sibayan J, Kollman C, Cohen N, Todd J, Hovorka R; CLOuD Consortium. Assessing the effect of closed-loop insulin delivery from onset of type 1 diabetes in youth on residual beta-cell function compared to standard insulin therapy (CLOuD study): a randomised parallel study protocol. BMJ Open. 2020 Mar 12;10(3):e033500. PMID: 32169925; PMCID: PMC7069267.
Boughton CK, Hartnell S, Allen JM, Fuchs J, Hovorka R. Training and Support for Hybrid Closed -Loop Therapy. J Diabetes Sci Technol. 2020 Sep 11;1932296820955168. PMID: 32914648.
Boughton CK, Hovorka R. The artificial pancreas. Curr Opin Organ Transplant. 2020 Aug;25 (4):336-342. PMID: 32618719.
Braukmann F, Jordan D, Jenkins B, Koulman A, Miska EA. SID-2 negatively regulates develop- ment likely independent of nutritional dsRNA uptake. RNA Biol. 2020 Oct 12;1-12. PMID: 33044912.
Brierley GV, Webber H,2 Rasijeff E, Grocott S, Siddle K, Semple RK. Anti-Insulin Receptor Anti- bodies Improve Hyperglycemia in a Mouse Model of Human Insulin Receptoropathy. Diabetes 2020;69:1–9. PMID: 32816962.
Burton NO, Riccio C, Dallaire A, Price J, Jenkins B, Koulman A, Miska EA. Cysteine Synthases CYSL-1 and CYSL-2 Mediate C. Elegans Heritable Adaptation to P. Vranovensis Infection. Nature Communications. 2020 Apr 8;11(1):1741. PMID: 32269224 PMCID: PMC7142082.
Calderon G , McRae A, Rievaj J, Davis J, Zandvakili I, Linker-Nord S, Burton D, Roberts G, Reimann F, Gedulin B, Vella A, LaRusso NF, Camilleri M, Gribble FM, Acosta A. Ileo-Colonic Delivery of Conjugated Bile Acids Improves Glucose Homeostasis Via Colonic GLP-1-Producing Enteroendocrine Cells in Human Obesity and Diabetes. EbioMedicine Vol 55, May 2020:102759. PMID: 32344198, PMCID: PMC7186521.
Campbell, J. R., Martchenko, A., Sweeney, M. E., Maalouf, M. F., Psichas, A., Gribble, F. M., Reimann, F., Brubaker PL. Essential role of syntaxin-binding protein-1 in the regulation of glucagon-like peptide-1 secretion. Endocrinology. Volume 161, Issue 5, May 2020. PMID: 32141504.
Campi I, Covelli D, Moran C, Fugazzola L, Cacciatore C, Orlandi F, Gallone G, Chatterjee K, Beck-Peccoz P, Persani L. The Differential Diagnosis of Discrepant Thyroid Function Tests: Insistent Pitfalls and Updated Flow-Chart Based on a Long-Standing Experience. Front Endocrinol (Lausanne) 2020 Jul 7;11:432. PMID: 32733382. PMC7358450.
Chae H, Augustin R, Gatineau E, Mayoux E, Bensellam M, Antoine N, Khattab F, Lai BK, Brusa D, Stierstorfer B, Klein H, Singh B, Ruiz L, Pieper M, Mark M, Herrera PL, Gribble FM, Reimann F, Wojtusciszyn A, Broca C, Rita N, Piemonti L, Gilon P. SGLT2 is not expressed in pancreatic α – and β-cells, and its inhibition does not directly affect glucagon and insulin secretion in rodents and humans. Mol Metab. 2020 Sep 5;42:101071. PMID: 32896668.
Chalmers J, Tung YCL, Liu CH, O’Kane CJ, O’Rahilly S, Yeo GSH. A multi-component screen for feeding behaviour and nutritional status in Drosophila to interrogate mammalian appetite-related genes. Mol Metab
. 2020 Nov 23;101127. doi: 10.1016/j.molmet.2020.101127. PMID: 33242659 PMCID: PMC7753202
Cheng W, Gonzalez I, Pan W, Tsang A H, Adams J, Nkoda E, Gordian D, Khoury B, Roelofs K, Evers S, MacKinnon A, Wu S, Frikke-Schmidt H, Flak J N, Trevaskis J L, Rhodes C J, Fukada S, Seeley R J, Sandoval D A, Olson D P, Blouet C, and Myers, Jr M G. Calcitonin Receptor Neurons in the Mouse Nucleus Tractus Solitarius Control Energy Balance via the non-Aversive Suppression of Feeding. Cell Metab. 2020 Feb 4;31(2):301-312.e5. PubMed PMID: 31955990.
Chiesa ST, Marcovecchio ML, Benitez-Aguirre P, Cameron FJ, Craig ME, Couper JJ, Davis EA, Dalton RN, Daneman D, Donaghue KC, Jones TW, Mahmud FH, Marshall SM, Neil HAW, Dunger DB, Deanfield JE; Adolescent Type 1 Diabetes Cardio-Renal Intervention Trial (AdDIT) Study Group. Vascular Effects of ACE (Angiotensin-Converting Enzyme) Inhibitors and Statins in Adolescents With Type 1 Diabetes. Hypertension. 2020 Dec;76(6):1734-1743. doi: 10.1161/HYPERTENSIONAHA.120.15721. PMID: 33100044.
Clarke N, Pechey E, Mantzari E, Blackwell AKM, De-Loyde K, Morris RW, Munafò MR, Marteau TM, Hollands GJ. Impact of Health Warning Labels Communicating the Risk of Cancer on Alcohol Selection: An Online Experimental Study. Addiction. 2020 Apr 8. PMID: 32267588.
Clément K, van den Akker E, Argente J, Bahm A, Chung WK, Connors H, De Waele K, Farooqi IS, Gonneau-Lejeune J, Gordon G, Kohlsdorf K, Poitou C, Puder L, Swain J, Stewart M, Yuan G, Wabitsch M, Kühnen P; Setmelanotide POMC and LEPR Phase 3 Trial Investigators. Efficacy and safety of setmelanotide, an MC4R agonist, in individuals with severe obesity due to LEPR or POMC deficiency: single-arm, open-label, multicentre, phase 3 trials. Lancet Diabetes Endocrinol. 2020 Dec;8(12):960-970. doi: 10.1016/S2213-8587(20)30364-8. PMID: 33137293.
Coll AP, Chen M, Taskar P, Rimmington D, Patel S, Tadross JA, Cimino I, Yang M, Welsh P, Virtue S, Goldspink DA, Miedzybrodzka EL, Konopka AR, Esponda RR, Huang JT, Tung YCL, Rodriguez-Cuenca S, Tomaz RA, Harding HP, Melvin A, Yeo GSH, Preiss D, Vidal-Puig A, Vallier L, Nair KS, Wareham NJ, Ron D, Gribble FM, Reimann F, Sattar N, Savage DB, Allan BB, O’Rahilly S. Publisher Correction: GDF15 mediates the effects of metformin on body weight and energy balance. Nature. 2020 Feb;578(7796):E24. PMID: 32051582.
Colombo M, McGurnaghan SJ, Blackbourn LAK, Dalton RN, Dunger D, Bell S, Petrie JR, Green F, MacRury S, McKnight JA, Chalmers J, Collier A, McKeigue PM, Colhoun HM; Scottish Diabetes Research Network (SDRN) Type 1 Bioresource Investigators. Comparison of Serum and Urinary Biomarker Panels With Albumin/Creatinine Ratio in the Prediction of Renal Function Decline in Type 1 Diabetes. Diabetologia. 2020 Apr;63(4):788-798. PMID: 31915892 PMCID: PMC7054370.
de Almeida-Faria J, Duque-Guimarães DE 1, Ong TP, Pantaleão LC, Carpenter AA, Loche E, Kusinski LC, Ashmore TJ, Antrobus R, Bushell M, Fernandez-Twinn DS, Ozanne SE. Maternal obesity during pregnancy leads to adipose tissue ER stress in mice via miR-126-mediated reduction in Lunapark. Diabetologia.
Dearden L, Buller S, Furigo IC, Fernandez-Twinn DS, Ozanne SE. Maternal obesity causes fetal hypothalamic insulin resistance and disrupts development of hypothalamic feeding pathways. Mol Metab. 2020 Sep 9;42:101079. PMID: 32919096 PMC7549144.
de Barros Mucci D, Kusinski LC, Wilsmore P, Loche E, Pantaleão LC, Ashmore TJ, Blackmore HL, Fernandez-Twinn DS, Carmo MDGTD, Ozanne SE. Impact of maternal obesity on placental transcriptome and morphology associated with fetal growth restriction in mice. Int J Obes (Lond). 2020 Mar 13. PMID:32203108.
Diederen KMJ, Fletcher PC. Dopamine, Prediction Error and Beyond. Neuroscientist. 2020 Apr 26:1073858420907591. PMID: 32338128.
Fisher BG, Thankamony A, Mendiola J, Petry CJ, Frederiksen H, Andersson AM, Juul A, Ong KK, Dunger DB, Hughes IA, Acerini CL. Maternal Serum Concentrations of Bisphenol A and Propyl Paraben in Early Pregnancy Are Associated With Male Infant Genital Development. Human Reproduction. 2020 Apr 28;35(4):913-928. PMID: 32325494.
Fleseriu M, Buchfelder M, Cetas JS, Fazeli PK, Mallea-Gil SM, Gurnell M, McCormack A, Pineyro MM, Syro LV, Tritos NA, Marcus HJ. Pituitary society guidance: pituitary disease management and patient care recommendations during the COVID-19 pandemic-an international perspective. Pituitary. 2020 Aug;23(4):327-337. PMID: 32556793. PMC7300368.
Fuchs J, Hovorka R. Closed-loop control in insulin pumps for type-1 diabetes mellitus: safety and efficacy. Expert Rev Med Devices. 2020 Jul 3;1-14. PMID: 32569476.
Fuchs J, Hovorka R. COVID-19 and Diabetes: Could Diabetes Technology Research Help Pave the Way for Remote Healthcare? Journal of Diabetes Science and Technology. 2020 May 30:1932296820929714. PMID: 32475169.
Furse S, Fernandez-Twinn DS, Jenkins B, Meek CL, Williams HEL, Smith GCS, CharnockJones DS, Ozanne SE, Koulman A. A high-throughput platform for detailed lipidomic analysis of a range of mouse and human tissues. Anal Bioanal Chem. 2020 Mar 7. Epub ahead of print. PMID: 32144454.
Furse S, Koulman A. Lipid extraction from dried blood spots and dried milk spots for untargeted high throughput lipidomics. Mol Omics. 2020 Sep 18. PMID: 32945330.
Furse S, Watkins AJ, Koulman A. Extraction of Lipids from Liquid Biological Samples for HighThroughput Lipidomics. Molecules. 2020 Jul 13;25(14):E3192. PMID: 32668693.
Galindo RJ, Umpierrez GE, Rushakoff RJ, Basu A, Lohnes S, Nichols JH, Spanakis EK, Espino- za J, Palermo NE, Awadjie DG, Bak L, Buckingham B, Cook CB, Freckmann G, Heinemann L, Hovorka R, Mathioudakis N, Newman T, O’Neal DN, Rickert M, Sacks DB, Seley JJ, Wallia A, Shang T, Zhang JY, Han J, Klonoff DC. Continuous Glucose Monitors and Automated Insulin Dosing Systems in the Hospital Consensus Guideline. J Diabetes Sci Technol. 2020 Sep 28;1932296820954163. PMID: 32985262.
Georgescu T, Lyons D, Doslikova B, Garcia AP, Marston O, Burke LK, Chianese R, Lam BYH, Yeo GSH, Rochford JJ, Garfield AS, Heisler LK. Neurochemical Characterization of Brainstem Pro-Opiomelanocortin Cells. Endocrinology. 2020 Apr 1;161(4). PMID: 32166324.
Gil A, Rueda R, Ozanne SE, van der Beek EM, van Loo-Bouwman C, Schoemaker M, Marinello V, Venema K, Stanton C, Schelkle B, Flourakis M, Edwards CA. Is there evidence for bacterial transfer via the placenta and any role in the colonization of the infant gut? – a systematic review. Crit Rev Microbiol. 2020 Aug 10;1-15. PMID: 32776793.
Giustina A, Barkhoudarian G, Beckers A, Ben-Shlomo A, Biermasz N, Biller B, Boguszewski C, Bolanowski M, Bollerslev J, Bonert V, Bronstein MD, Buchfelder M, Casanueva F, Chanson P, Clemmons D, Fleseriu M, Formenti AM, Freda P, Gadelha M, Geer E, Gurnell M, Heaney AP, Ho KKY, Ioachimescu AG, Lamberts S, Laws E, Losa M, Maffei P, Mamelak A, Mercado M, Molitch M, Mortini P, Pereira AM, Petersenn S, Post K, Puig-Domingo M, Salvatori R, Samson SL, Shimon I, Strasburger C, Swearingen B, Trainer P, Vance ML, Wass J, Wierman ME, Yuen KCJ, Zatelli MC, Melmed S. Multidisciplinary management of acromegaly: A consensus. Rev Endocr Metab Disord. 2020 Dec;21(4):667-678. PMID: 32914330.
Goh, K.J., Chen, J., Rocha, N. Semple, R.K. Human pluripotent stem cell-based models suggest preadipocyte senescence as a possible cause of metabolic complications of Werner and Bloom Syndromes. Scientific Reports. Vol 10, Article number: 7490 (2020). PMID: 32367056, PMC7198505.
Goldspink DA, Lu VB, Miedzybrodzka EL, Smith CA, Foreman RE, Billing LJ, Kay RG, *Reimann F, *Gribble FM (2020) Labelling and characterization of human GLP-1 secreting Lcells in primary ileal organoid culture. Cell Reports 2020 Jun 30;31(13):107833. doi: 10.1016/j.celrep.2020.107833. PMID: 32610134
Govaere O, Cockell S, Tiniakos D, Queen R, Younes R, Vacca M, Alexander L, Ravaioli F, Palmer J, Petta S, Boursier J, Rosso C, Johnson K, Wonders K, Day CP, Ekstedt M, Orešič M, Darlay R, Cordell HJ, Marra F, Vidal-Puig A, Bedossa P, Schattenberg JM, Clément K, Allison M, Bugianesi E, Ratziu V, Daly AK, Anstee QM. Transcriptomic profiling across the nonalcoholic fatty liver disease spectrum reveals gene signatures for steatohepatitis and fibrosis. Sci Transl Med. 2020 Dec 2;12(572):eaba4448. doi:10.1126/scitranslmed.aba4448. PMID: 33268509.
Groeneweg S, van Geest FS, Abacı A, Alcantud A, Ambegaonkar GP, Armour CM, Bakhtiani P, Barca D, Bertini ES, van Beynum IM, Brunetti-Pierri N, Bugiani M, Cappa M, Cappuccio G, Castellotti B, Castiglioni C, Chatterjee K, de Coo IFM, Coutant R, Craiu D, Crock P, DeGoede C, Demir K, Dica A, Dimitri P, Dolcetta-Capuzzo A, Dremmen MHG, Dubey R, Enderli A, Fairchild J, Gallichan J, George B, Gevers EF, Hackenberg A, Halász Z, Heinrich B, Huynh T, Kłosowska A, van der Knaap MS, van der Knoop MM, Konrad D, Koolen DA, Krude H, Lawson-Yuen A, Lebl J, Linder-Lucht M, Lorea CF, Lourenço CM, Lunsing RJ, Lyons G, Malikova J, Mancilla EE, McGowan A, Mericq V, Lora FM, Moran C, Müller KE, Oliver-Petit I, Paone L, Paul PG, Polak M, Porta F, Poswar FO, Reinauer C, Rozenkova K, Menevse TS, Simm P, Simon A, Singh Y, Spada M, van der Spek J, Stals MAM, Stoupa A, Subramanian GM, Tonduti D, Turan S, den Uil CA, Vanderniet J, van der Walt A, Wémeau JL, Wierzba J, de Wit MY, Wolf NI, Wurm M, Zibordi F, Zung A, Zwaveling-Soonawala N, Visser WE. Disease characteristics of MCT8 deficiency: an international, retrospective, multicentre cohort study. Lancet Diabetes Endocrinol. 2020 Jul;8 (7):594-605. PMID: 32559475.
Fang Z, Chen S, Manchanda Y, Bitsi S, Pickford P, David A, Shchepinova MM, Corrêa IR Jr, Hodson DJ, Broichhagen J, Tate EW, Reimann F, Salem V, Rutter GA, Tan T, Bloom SR, Tomas A, Jones B. Ligand-Specific Factors Influencing GLP-1 Receptor Post-Endocytic Trafficking and Degradation in Pancreatic Beta Cells. Int J Mol Sci. 2020 Nov 9;21(21):8404. doi: 10.3390/ijms21218404. PMID: 33182425 PMCID: PMC7664906
Haarsma J, Fletcher PC, Griffin JD, Taverne HJ, Ziauddeen H, Spencer TJ, Miller C, Katthagen T, Goodyer I, Diederen KMJ, Murray GK. Correction: Precision weighting of cortical unsigned prediction error signals benefits learning, is mediated by dopamine, and is impaired in psycho- sis. Mol Psychiatry. 2020 Oct 14. PMID: 33057170.
Hall Z, Chiarugi D, Charidemou E, Leslie J, Scott E, Pelligrinet L, Allison M, Mocciaro G, Anstee QM, Evan GI, Hoare M, Vidal-Puig A, Oakley F, Vacca M, Griffin JL. Lipid Remodelling in Hepatocyte Proliferation and Hepatocellular Carcinoma. Hepatology. 2020 May 27. PMID: 32460431.
Hammerle CM, Sandovici I, Brierley GV, Smith NM, Zimmer WE, Zvetkova I, Prosser HM, Sekita Y, Lam BYH, Ma M, Cooper WN, Vidal-Puig A, Ozanne SE, Medina-Gómez G, Constância M. Mesenchyme-derived IGF2 is a major paracrine regulator of pancreatic growth and function. PLoS Genet. 2020 Oct 15;16(10):e1009069. PMID: 33057429.
Herzig D, Studer D, Nakas CT, Kuenzli C, Stauffer TP, Hovorka R, Bally L. Effect of fully auto- mated closed-loop insulin delivery using faster aspart versus standard aspart on gluco- regulatory hormones in type 2 diabetes. Diabetes Obes Metab. 2020 Sep 9. PMID: 32902125.
Holt MK, Cook DR, Brierley DI, Richards JE, Reimann F, Gourine AV, Marina N, Trapp S. PPG Neurons in the Nucleus of the Solitary Tract Modulate Heart Rate but Do Not Mediate GLP-1 Receptor Agonist-Induced Tachycardia in Mice. Molecular Metabolism. 2020 May 21:101024. PMID: 32446875.
Hunter H, de Gracia Hahn D, Duret A, Ri Im Y, Cheah Q, Dong J, Fairey M, Hjalmarsson C, Li A, Kai Lim H, McKeown L, Mitrofan CG, Rao R, Utukuri M, Rowe IA, Mann JP. Weight loss, insulin resistance, and study design confound results in a meta-analysis of animal models of fatty liver. eLife 2020 Oct 16;9:e56573. doi: 10.7554/eLife.56573. PMID: 33063664 PMCID: PMC7647398.
Jenkins B, Ronis M, Koulman A. LC-MS Lipidomics: Exploiting a Simple High-Throughput Method for the Comprehensive Extraction of Lipids in a Ruminant Fat Dose-Response Study. Metabolites. 2020 Jul 17;10(7):296. PMID: 32709069. PMC7407148.
Jones KS, Parkington DA, Cox LJ, Koulman A. Erythrocyte transketolase activity coefficient (ETKAC) assay protocol for the assessment of thiamine status. Ann N Y Acad Sci. 2020 Dec 22. doi: 10.1111/nyas.14547. Epub ahead of print. PMID: 33354793.
Joustra SD, Roelfsema F, van Trotsenburg ASP, Schneider HJ, Kosilek RP, Kroon HM, Logan JG, Butterfield NC, Zhou X, Toufaily C, Bak B, Turgeon MO, Brûlé E, Steyn FJ, Gurnell M, Koulouri O, Le Tissier P, Fontanaud P, Duncan Bassett JH, Williams GR, Oostdijk W, Wit JM, Pereira AM, Biermasz NR, Bernard DJ, Schoenmakers N. IGSF1 Deficiency Results in Human and Murine Somatotrope Neurosecretory Hyperfunction. J Clin Endocrinol Metab. 2020 Mar 1;105 (3). PubMed PMID: 31650157.
Joustra SD, Roelfsema F, Paul van Trotsenburg AS, Schneider HJ, Kosilek RP, Kroon HM, Logan JG, Butterfield NC, Zhou X, Toufaily C, Bak B, Turgeon MO, Brûlé E, Steyn FJ, Gurnell M, Koulouri O, Le Tissier P, Fontanaud P, Bassett JHD, Williams GR, Oostdijk W, Wit JM, Pereira AM, Biermasz NR, Bernard DJ, Schoenmakers N. Response to Letter to the Editor: IGSF1 Deficiency Results in Human and Murine Somatotrope Neurosecretory Hyperfunction. J Clin Endocrinol Metab. 2020 Mar 24. PMID: 32211768
Joustra SD, Roelfsema F, van Trotsenburg ASP, Schneider HJ, Kosilek RP, Kroon HM, Logan JG, Butterfield NC, Zhou X, Toufaily C, Bak B, Turgeon MO, Brûlé E, Steyn FJ, Gurnell M, Koulouri O, Le Tissier P, Fontanaud P, Bassett JHD, Williams GR, Oostdijk W, Wit JM, Pereira AM, Biermasz NR, Bernard DJ, Schoenmakers N. Response to Letter to the Editor: “IGSF1 Deficiency Results in Human and Murine Somatotrope Neurosecretory Hyperfunction”. Journal of Clinical Endocrinology and Metabolism. 2020 Jun 1;105(6):dgaa147. PMID: 32211768 PMCID: PMC7159029.
Kanakis I, Alameddine M, Scalabrin M, van ‘t Hof RJ, Liloglou T, Ozanne SE, Goljanek-Whysall K, Vasilaki A. Low protein intake during reproduction compromises the recovery of lactationinduced bone loss in female mouse dams without affecting skeletal muscles. FASEB J. 2020 Jul 11. PMID: 32652768.
Kay RG, Foreman RE, Roberts GP, Hardwick R, Reimann F, Gribble FM. Mass Spectrometric Characterisation of the Circulating Peptidome Following Oral Glucose Ingestion in Control and Gastrectomised Patients. Rapid Communications in Mass Spectrometry. 2020 Jun 3:e8849. PMID: 32492232.
Khoo S, Lyons G, McGowan A, Gurnell M, Oddy S, Visser WE, van den Berg S, Halsall D, Taylor K, Chatterjee K, Moran C. Familial dysalbuminaemic hyperthyroxinemia interferes with current free thyroid hormone immunoassay methods. Eur J Endocrinol. 2020 Mar 1. PMID: 32213658.
Khoo S, Lyons G, McGowan A, Gurnell M, Oddy S, Visser WE, van den Berg S, Halsall D, Taylor K, Chatterjee K, Moran C. Familial Dysalbuminaemic Hyperthyroxinaemia Interferes With Current Free Thyroid Hormone Immunoassay Methods. European Journal of Endocrinology. 2020 Jun;182(6):533-538. PMID: 32213658 PMCID: PMC7222281.
Khoo S, Lyons G, Solomon A, Oddy S, Halsall D, Chatterjee K, Moran C. Familial dysalbuminemic hyperthyroxinemia confounding management of coexistent autoimmune thyroid disease. Endocrinol Diabetes Metab Case Rep. 2020 Feb 26;2020. PMID: 32101523.
Kohnke S, Meek CL. Don’t seek, don’t find: the diagnostic challenge of Wernicke’s encephalopathy. Ann Clin Biochem. 2020 Jul13;PMID: 32551830
Kolias A, Tysome J, Donnelly N, Sharma R, Gkrania-Klotsas E, Budohoski K, Karcheva S, Adapa R, Lawes I, Gurnell M, Hutchinson P, Bance M, Axon P, Santarius T, Mannion RJ. A Safe Approach to Surgery for Pituitary and Skull Base Lesions During the COVID-19 Pandemic. Acta Neurochirurgica (Wien). 2020 May 9:1-3. PMID: 32388681 PMCID: PMC7211050.
Krycer JR, Elkington SD, Diaz-Vegas A, Cooke KC, Burchfield JG, Fisher-Wellman KH, Cooney GJ, Fazakerley DJ, James DE. Mitochondrial Oxidants, but Not Respiration, Are Sensitive to Glucose in Adipocytes. Journal of Biological Chemistry. 2020 Jan 3;295(1):99-110. PMID: 31744882 PMCID: PMC6952605.
Kwok A, Zvetkova I, Virtue S, Luijten I, Huang-Doran I, Tomlinson P, Bulger DA, West J, Murfitt S, Griffin J, Alam R, Hart D, Knox R, Voshol P, Vidal-Puig A, Jensen J, O’Rahilly S, Semple RK. Truncation of Pik3r1 Causes Severe Insulin Resistance Uncoupled From Obesity and Dyslipidemia by Increased Energy Expenditure. Molecular Metabolism. 2020 May 18:101020. PMID: 32439336.
Langfield T, Pechey R, Pilling MA, Marteau TM. Glassware design and drinking behaviours: a review of impact and mechanisms using a new typology of drinking behaviours. Health Psychol Rev. 2020 Nov 18;1-23. doi: 10.1080/17437199.2020.1842230. PMID: 33140699.
Lawler K, Huang-Doran I, Sonoyama T, Collet TH, Keogh JM, Henning E, O’Rahilly S, Bottolo L, Farooqi IS. Leptin-mediated Changes in the Human Metabolome. Journal of Clinical Endocrinology and Metabolism. Volume 105, Issue 8, August 2020. PMID: 32392278.
Leelarathna L, Thabit H, Hovorka R, Evans M. Estimated HbA 1c and glucose management indi- cator (GMI): are they the same? Diabet Med. 2020 Oct 15;e14423. PMID: 33058254.
Lewis JE, Miedzybrodzka EL, Foreman RE, Woodward ORM, Kay RG, Goldspink DA, Gribble FM, Reimann F. Selective stimulation of colonic L cells improves metabolic outcomes in mice. Diabetologia. 2020 Apr 27. PMID: 32342115.
Leelarathna L, Thabit H, Willinska ME, Bally L, Mader JK, Arnolds S, Benesch C, Pieber TR, Shah VN, Carlson AL, Bergenstal RM, Evans ML, Hovorka R; AP@home04 and APCam11 consortia. Duration of Hybrid Closed-Loop Insulin Therapy to Achieve Representative Glycemic Outcomes in Adults With Type 1 Diabetes. Diabetes Care. 2020 Jan 16. pii: dc192041. Epub ahead of print. PubMed PMID: 31949086.
Liang ZS, Cimino I, Yalcin B, Raghupathy N, Vancollie VE, Ibarra-Soria X, Firth HV, Rimmington D, Farooqi IS, Lelliott CJ, Munger SC, O’Rahilly S, Ferguson-Smith AC, Coll, Logan DW. Trappc9 deficiency causes parent-of-origin dependent microcephaly and obesity. Plos Genetics. 2020 Sept 2. PMID: 32877400 PMC7467316.
Lockhart S, O’Rahilly S. When two pandemics meet: Why is obesity associated with increased COVID-19 mortality. Med. 25 June 2020.
Lockhart SM, Saudek V, O’Rahilly S. GDF15: A hormone conveying somatic distress to the brain. Endocrine Reviews. Vol 41 Issue 4 2020 Apr 20. PMID: 32310257. Lockhart SM, O’Rahilly S. The wasting hormone GDF15 frees up fat to fight infection. Nature Metabolism 2019;1:935-936 (news and views).
Löfvenborg JE, Carlsson S, Andersson T, Hampe CS, Koulman A, Chirlaque Lopez MD, Jakszyn P, Katzke VA, Kühn T, Kyrø C, Masala G, Nilsson PM, Overvad K, Panico S, Sánchez MJ, van der Schouw Y, Schulze MB, Tjønneland A, Weiderpass E, Riboli E, Forouhi NG, Sharp SJ, Rolandsson O, Wareham NJ. Interaction Between GAD65 Antibodies and Dietary Fish Intake or Plasma Phospholipid n-3 Polyunsaturated Fatty Acids on Incident Adult-Onset Diabetes: The EPIC-InterAct Study. Diabetes Care. 2020 Dec 10;dc201463. doi: 10.2337/dc20-1463. PMID: 33303636.
Lund ML , Sorrentino G, Egerod KL, Kroone C, Mortensen B, Knop FK, Reimann F, Gribble FM, Drucker DJ, de Koning EJP, Schoonjans K, Bäckhed F, Schwartz TW, Petersen N (2020) L-cell differentiation is induced by bile acids through GLP-1 and paracrine serotonin signaling. Diabetes 2020 Apr;69(4):614-623. doi: 10.2337/db19-0764. Epub 2020 Feb 10. PMID: 32041793 PMCID: PMC7224989
MacFarlane J, Bashari WA, Senanayake R, Gillett D, van der Meulen M, Powlson AS, Kolias A, Koulouri O, Gurnell M. Advances in the Imaging of Pituitary Tumors. Endocrinol Metab Clin North Am. 2020 Sep;49(3):357-373. PMID: 32741476.
Magee LA, Banerjee A, Coleman MA, von Dadelszen P, Denison F, Farmer A, Finer S, FoxRushby J, Holt R, Lindsay RS, MacKillop L, Maresh M, McAuliffe FM, McCance D, McCarthy FP, Meek CL, Murphy HR, Myers J, Pasupathy D, Poston L, Reynolds RM, Saravanan P, Scott E, Sukumar N, Tan B, Thangaratinam S, Webster L, White SL, Williamson C. Gestational Diabetes Mellitus: An opportunity to improve long term health in mothers and children. Lancet Diabetes and Endocrinology. ISSN 2213-8587 (In Press)
Mahú I, Barateiro A, Rial-Pensado E, Martinéz-Sánchez N, Vaz SH, Cal PMSD, Jenkins B, Rodrigues T, Cordeiro C, Costa MF, Mendes R, Seixas E, Pereira MMA, Kubasova N, Gres V, Morris I, Temporão C, Olivares M, Sanz Y, Koulman A, Corzana F, Sebastião AM, López M, Bernardes GJL, Domingos AI. Brain-Sparing Sympathofacilitators Mitigate Obesity Without Adverse Cardiovascular Effects. Cell Metabolism. 2020 Jun 2;31(6):1120-1135.e7. PMID: 32402266.
Marcovecchio ML, Colombo M, Dalton RN, McKeigue PM, Benitez-Aguirre P, Cameron F, Chiesa ST, Couper J, Craig M, Daneman D, Davis E, Deanfield J, Donaghue K, Jones TW, Mahmud FH, Marshall SM, Neil HAW, Colhoun HM, Dunger DB; AdDIT and the SDRNT1BIO Investigators. Biomarkers associated with early stages of kidney disease in adolescents with type 1 diabetes. Pediatr Diabetes. 2020 Aug 11. PMID: 32783254.
Marcovecchio ML, Gorman S, Watson LPE, Dunger DB, Beardsall K. Catch-Up Growth in Children Born Small for Gestational Age Related to Body Composition and Metabolic Risk at Six Years of Age in the UK. Horm Res Paediatr. 2020 Jul 23;93(2):119-127. PMID: 32702692.
Marcovecchio ML, Wicker LS, Dunger DB, Dutton SJ, Kopijasz S, Scudder C, Todd JA, Johnson PRV. Interleukin-2 Therapy of Autoimmunity in Diabetes (ITAD): A Phase 2, Multicentre, DoubleBlind, Randomized, Placebo-Controlled Trial. Wellcome Open Res. 2020 Mar 20;5:49. PMID: 32399500. PMCID: PMC7194454.
Marenne G, Hendricks AE, Perdikari A, Bounds R, Payne F, Keogh JM, Lelliott CJ, Henning E, Pathan S, Ashford S, Bochukova EG, Mistry V, Daly A, Hayward C; INTERVAL, UK10K Consortium, Wareham NJ, O’Rahilly S, Langenberg C, Wheeler E, Zeggini E, Farooqi IS, Barroso I. Exome Sequencing Identifies Genes and Gene Sets Contributing to Severe Childhood Obesity, Linking PHIP Variants to Repressed POMC Transcription. Cell Metabolism. 2020 Jun 2;31 (6):1107-1119.e12. PMID: 32492392.
Marques P, Caimari F, Hernández-Ramírez LC, Collier D, Iacovazzo D, Ronaldson A, Magid K, Lim CT, Stals K, Ellard S, Grossman AB, Korbonits M; FIPA Consortium. Significant Benefits of AIP Testing and Clinical Screening in Familial Isolated and Young-onset Pituitary Tumors. Journal of Clinical Endocrinology and Metabolism. 2020 Jun 1;105(6):dgaa040. PMID: 31996917 PMCID: PMC7137887.
Mazarello Paes V, Barrett JK, Dunger DB, Gevers EF, Taylor-Robinson DC, Viner RM, Stephenson TJ. Factors predicting poor glycemic control in the first two years of childhood onset type 1 diabetes in a cohort from East London, UK: Analyses using mixed effects fractional polynomial models. Pediatr Diabetes. 2020 Mar;21(2):288-299. Epub 2019 Dec 17. PubMed PMID:31782879.
Meek CL, Lewis HB, Burling K, Reimann F, Gribble F. Expected values for gastrointestinal and pancreatic hormone concentrations in healthy volunteers in the fasting and postprandial state. Ann Clin Biochem. 2020 Dec 7;4563220975658. doi: 10.1177/0004563220975658. PMID: 33175577.
C L Meek, R S Lindsay, E M Scott, C E Aiken, J Myers, R Reynolds, D Simmons, J M Yamamoto, D R McCance, H R Murphy. Approaches to screening for hyperglycaemia in pregnant women during and after the Covid-19 pandemic. Diabet Med. 2020 Aug 4. PMID: 32750184
Melvin A, Cowan C, Lam B, Buller S, Rainbow K, Yeo GS, O’Rahilly S. SUN-LB107 Functional Characterisation of Human Heterozygous Non-Synonymous MC3R Variants. Journal of the Endocrine Society, Volume 4, Issue Supplement_1, April-May 2020.
Miedzybrodzka EL, Foreman RE, Galvin SG, Larraufie P, George AL, Goldspink DA, Reimann F, Gribble FM, Kay RG. Organoid Sample Preparation and Extraction for LC-MS Peptidomics. STAR Protoc. 2020 Nov 25;1(3):100164. doi: 10.1016/j.xpro.2020.100164. PMID:33377058 PMCID:PMC7757358
Modvig I, Andersen D, Grunddal K, Kuhre RE, Martinussen C, Christiansen C, Ørskov C, Larraufie P, Kay RG, Reimann F, Gribble FM, Hartmann B, Bojsen-Møller K, Madsbad S, Wewer Albrechtsen N, Holst JJ (2020) Secretin release after Roux-en-Y Gastric Bypass reveals a population of glucose-sensitive S-cells in distal small intestine. Int J Obes (Lond). 2020 Feb 3. doi: 10.1038/s41366-020-0541-7. PMID: 32015474
Montagnese M, Knolle F, Haarsma J, Griffin JD, Richards A, Vertes PE, Kiddle B, Fletcher PC, Jones PB, Owen MJ, Fonagy P, Bullmore ET, Dolan RJ; NSPN Consortium, Moutoussis M, Goodyer IM, Murray GK. Reinforcement Learning as an Intermediate Phenotype in Psychosis? Deficits Sensitive to Illness Stage but Not Associated With Polygenic Risk of Schizophrenia in the General Population. Schizophrenia Research. 2020 May 7:S0920-9964(20)30229-2. PMID: 32389614.
Moran C, Seger C, Taylor K, Oddy S, Burling K, Rajanayagam O, Fairall L, McGowan AN, Lyons G, Halsall D, Gurnell M, Schwabe J, Chatterjee VK, Strey C. HYPERTHYROXINEMIA AND HYPERCORTISOLEMIA DUE TO FAMILIAL DYSALBUMINEMIA. Thyroid. 2020 Jul 15. PMID: 32669045.
Napier C, Gan EH, Mitchell AL, Gilligan LC, Rees DA, Moran C, Chatterjee K, Vaidya B, James RA, Mamoojee Y, Ashwell S, Arlt W, Pearce SHS. Residual Adrenal Function in Autoimmune Addison’s Disease-Effect of Dual Therapy With Rituximab and Depot Tetracosactide. J Clin Endocrinol Metab. 2020 Apr 1;105(4). PMID: 31863094. PMCID: PMC7067544.
Niechciał E, Acerini CL, Chiesa ST, Stevens T, Dalton RN, Daneman D, Deanfield JE, Jones TW, Mahmud FH, Marshall SM, Neil HAW, Dunger DB, Marcovecchio ML; Adolescent Type 1 Diabetes Cardio-Renal Intervention Trial (AdDIT) Study Group; Medication Adherence During Adjunct Therapy With Statins and ACE Inhibitors in Adolescents With Type 1 Diabetes. Diabetes Care. 2020 May;43(5):1070-1076. PMID: 32108022.
Nicholas, L., Nagao, M., Kusinski, L., Twinn, D., Eliasson, L., & Ozanne, S. (2020). Exposure to maternal obesity programs sex differences in pancreatic islets of the offspring in mice. Diabetologia, 63 (2), 324-337. PMID: 31773193. PMCID: PMC6946752.
Ong KK, Cheng TS, Olga L, Prentice PM, Petry CJ, Hughes IA, Dunger DB. Which Infancy Growth Parameters Are Associated With Later Adiposity? The Cambridge Baby Growth Study. Annals of Human Biology. 2020 Mar;47(2):142-149. PMID: 32429763.
Petry CJ, Ong KK, Hughes IA, Dunger DB. Multiple Micronutrient Supplementation during Pregnancy and Increased Birth Weight and Skinfold Thicknesses in the Offspring: The Cambridge Baby Growth Study. Nutrients. 2020 Nov 12;12(11):3466. doi: 10.3390/nu12113466. PMID: 33198145 PMCID: PMC7697774.
Prins D, Park HJ, Watcham S, Li J, Vacca M, Bastos HP, Gerbaulet A, Vidal-Puig A, Göttgens B, Green AR. The stem/progenitor landscape is reshaped in a mouse model of essential thrombocythemia and causes excess megakaryocyte production. Sci Adv. 2020 Nov 25;6(48):eabd3139. doi: 10.1126/sciadv.abd3139. PMID: 33239297 PMCID: PMC7688335
Razolli DS, de Araújo TM, Sant Apos Ana MR, Kirwan P, Cintra DE, Merkle FT, Velloso LA. Proopiomelanocortin Processing in the Hypothalamus Is Directly Regulated by Saturated Fat: Implications for the Development of Obesity. Neuroendocrinology. 2020;110(1-2):92-104. Epub 2019 May20. PubMed PMID: 31104058.
Quinn M, Bashari W, Smith D, Gurnell M, Agha A. A remarkable case of thyrotoxicosis initially caused by graves’ disease followed by a probable TSHoma – a case report. BMC Endocr Disord. 2020 Aug 27;20(1):133. PMID: 32854689 PMC7457301.
Reimann, F., Lewis, J. E., Miedzybrodzka, E. L., Foreman, R. E., Woodward, O. R., Kay, R. G., Goldspink, D. A., & et al. Selective stimulation of colonic L-cells improves metabolic outcomes in mice. Diabetologia. 2020 Jul;63(7):1396-1407. doi: 10.1007/s00125-020-05149-w. Epub 2020 Apr 27. PMID: 32342115 PMCID: PMC7286941
Roseboom TJ, Ozanne SE, Godfrey KM, Isasi CR, Itoh H, Simmons R, Bansal A, Barker M, Plosch T, Sloboda DM, Matthews SG, Fall CHD, Poston L, Hanson MA. Unheard, unseen and unprotected: DOHaD council’s call for action to protect the younger generation from the long- term effects of COVID-19. J Dev Orig Health Dis. 2020 Sep 23;1-3. PMID: 32962780.
Roth E, Benoit S, Quentin B, Lam B, Will S, Ma M, Heeley N, Darwish T, Shrestha Y, Gribble F, Reimann F, Pshenichnaya I, Yeo G, Baker DJ, Trevaskis JL, Blouet C. Behavioural and neurochemical mechanisms underpinning the feeding-suppressive effect of GLP-1/CCK combinatorial therapy. Mol Metab. 2020 Nov 19;43:101118. doi: 10.1016/j.molmet.2020.101118. PMID: 33221554 PMCID: PMC7720077.
Rowitch DH, O’Rahilly S, Smith GCS. A classification of video-conferencing related illness: the zoomnotic diseases. QJM. 2020 Nov 27;hcaa316. doi: 10.1093/qjmed/hcaa316. PMID: 33245119
Rubio C, Puerto M, García-Rodríquez JJ, Lu VB, García-Martínez I, Alén R, Sanmartín-Salinas P, Toledo-Lobo MV, Saiz J, Ruperez J, Barbas C, Menchén L, Gribble FM, Reimann F, Guijarro LG, Carrascosa JM, Valverde ÁM. Impact of global PTP1B deficiency on the gut barrier permeability during NASH in mice. Mol Metab. 2020 Feb 6;35:100954. PMID: 32244182. PMCID: PMC7082558.
Sam AH, Reid MD, Thakerar V, Gurnell M, Westacott R, Reed MWR, Brown CA. National inter-rater agreement of standardised simulated-patient-based assessments. Med Teach. 2020 Nov 16;1-6. doi: 10.1080/0142159X.2020.1845909. PMID: 33198538.
Samuelson I, Vidal-Puig A. Studying Brown Adipose Tissue in a Human in vitro Context. Front Endocrinol (Lausanne). 2020 Sep 15;11:629. PMID: 33042008 PMC7523498.
Sarnobat D, Moffett C R, Gault V A, Tanday N, Reimann F, Gribble F M, Flatt P R, Irwin N. Effects of long-acting GIP, xenin and oxyntomodulin peptide analogues on alpha-cell transdifferentiation in insulin-deficient diabetic GluCreERT2;ROSA26-eYFP mice. Peptides. 2020 Mar;125:170205 Review. PMID: 31738969 PMCID: PMC7212078
Sarnobat D, Moffett CR, Tanday N, Reimann F, Gribble FM, Flatt PR, Tarasov AI. Antidiabetic drug therapy alleviates type 1 diabetes in mice by promoting pancreatic α-cell transdifferentia- tion. Biochem Pharmacol. 2020 Sep 11;182:114216. PMID: 32926875.
Schoenmakers E, Chatterjee K. Human disorders affecting the selenocysteine incorporation pathway cause systemic selenoprotein deficiency. Antioxididants and Redox Signalling. 2020 May 11. PMID: 32295391.
Smith LE, Mottershaw AL, Egan M, Waller J, Marteau TM, Rubin GJ. The impact of believing you have had COVID-19 on self-reported behaviour: Cross-sectional survey. PLoS One. 2020 Nov 4;15(11):e0240399. doi: 10.1371/journal.pone.0240399. PMID: 33147219 PMCID: PMC7641362
Snowden SG, Fernandes HJR, Kent J, Foskolou S, Tate P, Field SF, Metzakopian E, Koulman A. Development and Application of High-Throughput Single Cell Lipid Profiling: A Study of SNCA-A53T Human Dopamine Neurons. iScience. 2020 Oct 21;23(11):101703. doi: 10.1016/j.isci.2020.101703. eCollection 2020 Nov 20. PMID: 33196026 PMCID: PMC7644967.
Snowden SG, Korosi A, de Rooij SR, Koulman A. Combining lipidomics and machine learning to measure clinical lipids in dried blood spots. Metabolomics. 2020 Jul 24;16(8):83. PMID: 32710150. PMC7381462.
Sonoyama T, Stadler LKJ, Zhu M, Keogh JM, Henning E, Hisama F, Kirwan P, Jura M, Blaszczyk BK, DeWitt DC, Brouwers B, Hyvönen M, Barroso I, Merkle FT, Appleyard SM, Wayman GA, Farooqi IS. Human BDNF/TrkB Variants Impair Hippocampal Synaptogenesis and Associate With Neurobehavioural Abnormalities. Scientific Reports. 2020 Jun 3;10(1):9028. PMID: 32493978.
Suehs CM, Menzies-Gow A, Price D, Bleecker ER, Canonica GW, Gurnell M, Bourdin A; Oral Corticosteroids Tapering Delphi Expert Panel. Expert Consensus on the Tapering of Oral Corticosteroids for the Treatment of Asthma: A Delphi Study. Am J Respir Crit Care Med. 2020 Oct 28. doi: 10.1164/rccm.202007-2721OC. PMID: 33112646.
Sullivan SA, Kounali D, Cannon M, David AS, Fletcher PC, Holmans P, Jones H, Jones PB, Linden DEJ, Lewis G, Owen MJ, O’Donovan M, Rammos A, Thompson A, Wolke D, Heron J, Zammit S. A Population-Based Cohort Study Examining the Incidence and Impact of Psychotic Experiences From Childhood to Adulthood, and Prediction of Psychotic Disorder. Am J Psychiatry. 2020 Jan 7. Epub ahead of print. PubMed PMID: 31906710.
Tarry-Adkins JL, Aiken CE, Ozanne SE. Comparative Impact of Pharmacological Treatments for Gestational Diabetes on Neonatal Anthropometry Independent of Maternal Glycaemic Control: A Systematic Review and Meta-Analysis. PLoS Med. 2020 May 22;17(5):e1003126. PMID: 32442232 PMCID: PMC7244100.
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Thackray AM, Lam B, Shahira Binti Ab Razak A, Yeo G, Bujdoso R. Transcriptional signature of prion-induced neurotoxicity in a Drosophila model of transmissible mammalian prion disease. Biochem J. 2020 Feb 28;477(4):833-852. PMID: 32108870.
Tsang AH, Nuzzaci D, Darwish T, Samudrala H, Blouet C. Nutrient sensing in the nucleus of the solitary tract mediates non-aversive suppression of feeding via inhibition of AgRP neurons. Mol Metab. 2020 Sep 6;42:10107. PMID: 32898712 PMC7549147.
Tung L, O’Rahilly S. Constitutional Thinness: tALKing the tALK or wALKing the wALK? Cell Metabolism, 01 Jul 2020, 32(1):8-10. PMID: 32640247.
Uter J, Heldmann M, Rogge B, Obst M, Steinhardt J, Brabant G, Moran C, Chatterjee K, Münte TF. Patients with mutations of the Thyroid hormone beta-receptor show an ADHD-like phenotype for performance monitoring: an electrophysiological study. Neuroimage Clin. 2020 Mar 19;26:102250. PMID: 32217468.
Vacca M, Leslie J, Virtue S, Lam BYH, Govaere O, Tiniakos D, Snow S, Davies S, Petkevicius K, Tong Z, Peirce V, Nielsen MJ, Ament Z, Li W, Kostrzewski T, Leeming DJ, Ratziu V, Allison MED, Anstee QM, Griffin JL, Oakley F, Vidal-Puig A. Bone morphogenetic protein 8B promotes the progression of non-alcoholic steatohepatitis. Nat Metab. 2020 Jun;2(6):514-531. PMID: 32694734.
Vergari E, Denwood G, Salehi A, Zhang Q, Adam J, Alrifaiy A, Wernstedt Asterholm I, Benrick A, Chibalina MV, Eliasson L, Guida C, Hill TG, Hamilton A, Ramracheya R, Reimann F, Rorsman NJG, Spilliotis I, Tarasov AI, Walker JN, Rorsman P, Briant LJB. Somatostatin secretion by Na(+)-dependent Ca(2+)-induced Ca(2+) release in pancreatic delta-cells. Nat Metab. 2020 Jan;2(1):32-40. Epub 2020 Jan 20. PubMed PMID: 31993555; PubMed Central PMCID: PMC6986923.
Vogelezang S, [31 authors], Farooqi IS, [110 authors]; Early Growth Genetics Consortium, Jad- doe VWV, Grant SFA, Felix JF. Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits. PLoS Genet. 2020 Oct 12;16(10):e1008718. PMID: 33045005.
von Schnurbein J, Adams C, Akinci B, Ceccarini G, D’Apice MR, Gambineri A, Hennekam RCM, Jeru I, Lattanzi G, Miehle K, Nagel G, Novelli G, Santini F, SantosSilva E, Savage DB, Sbraccia P, Schaaf J, Sorkina E, Tanteles G, Vantyghem MC, Vatier C, Vigouroux C, Vorona E, AraújoVilar D, Wabitsch M. European lipodystrophy registry: background and structure. Orphanet J Rare Dis. 2020 Jan 15;15(1):17. PubMed PMID: 31941540; PubMed Central PMCID: PMC6964101.
Wagstyl K, Larocque S, Cucurull G, Lepage C, Cohen JP, Bludau S, Palomero-Gallagher N, Lewis LB, Funck T, Spitzer H, Dickscheid T, Fletcher PC, Romero A, Zilles K, Amunts K, Bengio Y, Evans AC. BigBrain 3D Atlas of Cortical Layers: Cortical and Laminar Thickness Gradients Diverge in Sensory and Motor Cortices. PLoS Biol. 2020 Apr 3;18(4):e3000678. PMID: 32243449 PMCID: PMC7159250.
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Wargent ET, Martin-Gronert MS, Cripps RL, Heisler LK, Yeo GSH, Ozanne SE, Arch JRS, Stocker CJ. Developmental programming of appetite and growth in male rats increases hypothalamic serotonin (5-HT)5A receptor expression and sensitivity. Int J Obes (Lond). 2020 Jul 27. PMID: 32719434.
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Worth AA, Shoop R, Tye K, Feetham CH, D’Agostino G, Dodd GT, Reimann F, Gribble FM, Beebe EC, Dunbar JD, Alexander-Chacko JT, Sindelar DK, Coskun T, Emmerson PJ, Luckman SM. The cytokine GDF15 signals through a population of brainstem cholecystokinin neurons to mediate anorectic signalling. Elife. 2020 Jul 29;9:e55164. PMID: 32723474. PMC7410488.
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2019

Adriaensses A; Gribble FM; Reimann F. The glucose-dependent insulinotropic polypeptide signalling axis in the central nervous system. Peptides. 2020 Mar;125:170194. Epub 2019 Nov 4. Review. PMID: 31697967
Adriaenssens AE, Biggs EK, Darwish T, Tadross J, Sukthankar T, Girish M, Polex-Wolf J, Lam BY, Zvetkova I, Pan W, Chiarugi D, Yeo GSH, Blouet C, Gribble FM, Reimann F. GlucoseDependent Insulinotropic Polypeptide Receptor-Expressing Cells in the Hypothalamus Regulate Food Intake. Cell Metab. 2019 Aug 19. [Epub ahead of print] PMID: 31447324.
Ahmed RM, Landin-Romero R, Liang CT, Keogh JM, Henning E, Strikwerda-Brown C, Devenney EM, Hodges JR, Kiernan MC, Farooqi IS, Piguet O. Neural networks associated with body composition in frontotemporal dementia. Ann Clin Transl Neurol. 2019 Sep;6(9):1707-1717. PMID: 31461580.
Aiken CE, Tarry-Adkins JL, Ashmore TJ, Ozanne SE. Early life environment influences the trajectory of post-partum weight loss in adult female rats. Reprod Biomed Online. 2019 May;38(5):779-786. doi: 10.1016/j.rbmo.2018.12.002. Epub 2018 Dec 12. PMID: 30885667. PMCID: PMC6491499
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Leelarathna L, Beck RW, Bergenstal RM, Thabit H, Hovorka R; APCam11, AP@home04, and APCam08 Investigators. Glucose Management Indicator (GMI): Insights and Validation Using Guardian 3 and Navigator 2 Sensor Data. Diabetes Care. 2019 Apr;42(4):e60-e61. doi: 10.2337/dc18-2479. Epub 2019 Feb 6. PMID: 30728221
Lippincott MF, León S, Chan YM, Fergani C, Talbi R, Farooqi IS, Jones CM, Arlt W, Stewart SE, Cole TR, Terasawa E, Hall JE, Shaw ND, Navarro VM, Seminara SB. Hypothalamic Reproductive Endocrine Pulse Generator Activity Independent of Neurokinin B and Dynorphin Signaling. J Clin Endocrinol Metab. 2019 May 27. [Epub ahead of print]. PMID:31132118; PMCID:PMC6736049
López-Tello J, Pérez-García V, Khaira J, Kusinski LC, Cooper WN, Andreani A, Grant I, Fernández de Liger E, Lam BY, Hemberger M, Sandovici I, Constancia M, Sferruzzi-Perri AN. Fetal and trophoblast PI3K p110α have distinct roles in regulating resource supply to the growing fetus in mice. Elife. 2019 Jun 26;8. PMID:31241463; PMCID: PMC6634971
Lotta LA, Mokrosiński J, Mendes de Oliveira E, Li C, Sharp SJ, Luan J, Brouwers B, Ayinampudi V, Bowker N, Kerrison N, Kaimakis V, Hoult D, Stewart ID, Wheeler E, Day FR, Perry JRB, Langenberg C, Wareham NJ, Farooqi IS. Human Gain-of-Function MC4R Variants Show Signaling Bias and Protect against Obesity. Cell. 2019 Apr 18;177(3):597-607.e9. PMID:31002796; PMCID: PMC6476272
Lu VB, Rievaj J, O’Flaherty EA, Smith CA, Pais R, Pattison LA, Tolhurst G, Leiter AB, Bulmer DC, Gribble FM, Reimann F. Adenosine triphosphate is co-secreted with glucagon-like peptide-1 to modulate intestinal enterocytes and afferent neurons. Nat Commun. 2019 Mar 4;10(1):1029. doi: 10.1038/s41467-019-09045-9. PMID: 30833673 PMCID: PMC6399286
Macaulay S, Buchmann EJ, Dunger DB, Norris SA. Reliability and validity of last menstrual period for gestational age estimation in a low-to-middle-income setting. J Obstet Gynaecol Res. 2019 Jan;45(1):217-225. doi: 10.1111/jog.13801. Epub 2018 Sep 6. PMID: 30191629
Maniero C, Scudieri P, Haris Shaikh L, Zhao W, Gurnell M, Galietta LJV, Brown MJ. ANO4 (Anoctamin 4) Is a Novel Marker of Zona Glomerulosa That Regulates Stimulated Aldosterone Secretion. Hypertension. 2019 Nov;74(5):1152-1159. PMID: 31564164.
Mann JP, Savage DB. What lipodystrophies teach us about the metabolic syndrome. J Clin Invest. 2019 Aug 5;130:4009-4021. Review. PMID: 31380809.
Marcovecchio ML, Dalton RN, Daneman D, Deanfield J, Jones TW, Neil HAW, Dunger DB; Adolescent type 1 Diabetes cardio-renal Intervention Trial (AdDIT) study group. A new strategy for vascular complications in young people with type 1 diabetes mellitus. Nat Rev Endocrinol. 2019 Jul;15(7):429-435. Review. PMID:30996294
Mazarello Paes V, Barrett JK, Taylor-Robinson DC, Chesters H, Charalampopoulos D, Dunger DB, Viner RM, Stephenson TJ. Effect of early glycemic control on HbA1c tracking and development of vascular complications after 5 years of childhood onset type 1 diabetes: Systematic review and meta -analysis. Pediatr Diabetes. 2019 Aug;20(5):494-509. Epub 2019 Apr 24. Review. PMID:30932298; PMCID:PMC6701989
Medic N, Kochunov P, Ziauddeen H, Ersche KD, Nathan PJ, Ronan L, Fletcher PC. BMI-related cortical morphometry changes are associated with altered white matter structure. Int J Obes (Lond). 2019 Mar;43(3):523-532. PMID: 30568264 PMCID: PMC6462878
Melvin A, Lacerda E, Dockrell S M, O’Rahilly S, Nacul L. Circulating levels of GDF15 in patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. J Transl Med. 2019 Dec 4;17 (1):409. PMID: 31801546. PMCID: PMC6892232
Melvin A, Stears A, Savage DB. Recent developments in lipodystrophy. Curr Opin Lipidol. 2019 Aug;30(4):284-290. PMID: 31135595.
Menting MD, Mintjens S, van de Beek C, Frick CJ, Ozanne SE, Limpens J, Roseboom TJ, Hooijmans CR, van Deutekom AW, Painter RC. Maternal obesity in pregnancy impacts offspring cardiometabolic health: Systematic review and meta-analysis of animal studies. Obes Rev. 2019 May;20(5):675-685. doi: 10.1111/obr.12817. PMID: 30633422 PMCID: PMC6849816
Menzies-Gow A, Corren J, Bel EH, Maspero J, Heaney LG, Gurnell M, Wessman P, Martin UJ, Siddiqui S, Garcia Gil E. Corticosteroid tapering with benralizumab treatment for eosinophilic asthma: PONENTE Trial. ERJ Open Res. 2019 Sep 25;5(3). PMID: 31579676.
Müller TD, Finan B, Bloom SR, D’Alessio D, Drucker DJ, Flatt PR, Fritsche A, Gribble F, Grill HJ, Habener JF, Holst JJ, Langhans W, Meier JJ, Nauck MA, Perez-Tilve D, Pocai A, Reimann F, Sandoval DA, Schwartz TW, Seeley RJ, Stemmer K, Tang-Christensen M, Woods SC, DiMarchi RD, Tschöp MH. Glucagon-like peptide 1 (GLP-1). Mol Metab. 2019 Dec;30:72-130. Epub 2019 Sep 30. Review. PMID: 31767182. PMCID: PMC6812410.
Musial B, Fernandez-Twinn DS, Duque-Guimaraes D, Carr SK, Fowden AL, Ozanne SE, Sferruzzi-Perri AN. Exercise alters the molecular pathways of insulin signaling and lipid handling in maternal tissues of obese pregnant mice. Physiol Rep. 2019 Aug;7(16). PMID: 31466137.
Musolino G, Allen JM, Hartnell S, Wilinska ME, Tauschmann M, Boughton C, Campbell F, Denvir L, Trevelyan N, Wadwa P, DiMeglio L, Buckingham BA, Weinzimer S, Acerini CL, Hood K, Fox S, Kollman C, Sibayan J, Borgman S, Cheng P, Hovorka R. Assessing the efficacy, safety and utility of 6-month day-and-night automated closed-loop insulin delivery under free-living conditions compared with insulin pump therapy in children and adolescents with type 1 diabetes: an open-label, multicentre, multinational, single-period, randomised, parallel group study protocol. BMJ Open. 2019 Jun 3;9(6):e027856. PMID:31164368; PMCID: PMC6561428
Musolino G, Dovc K, Boughton CK, Tauschmann M, Allen JM, Nagl K, Fritsch M, Yong J, Metcalfe E, Schaeffer D, Fichelle M, Schierloh U, Thiele AG, Abt D, Kojzar H, Mader JK, Slegtenhorst S, Ashcroft N, Wilinska ME, Sibayan J, Cohen N, Kollman C, Hofer SE, Fröhlich -Reiterer E, Kapellen TM, Acerini CL, de Beaufort C, Campbell F, Rami-Merhar B, Hovorka R; Kidsap Consortium. Reduced burden of diabetes and improved quality of life: Experiences from unrestricted day-and-night hybrid closed-loop use in very young children with type 1 diabetes. Pediatr Diabetes. 2019 May 29. [Epub ahead of print] PMID:31140654; PMCID:PMC6771658
Nicholas LM, Ozanne SE. Early life programming in mice by maternal overnutrition: mechanistic insights and interventional approaches. Philos Trans R Soc Lond B Biol Sci. 2019 Apr 15;374(1770):20180116. PMID:30966886; PMCID:PMC6460073
Nyimanu D, Kay RG, Sulentic P, Kuc RE, Ambery P, Jermutus L, Reimann F, Gribble FM, Cheriyan J, Maguire JJ, Davenport AP. Development and validation of an LC-MS/MS method for detection and quantification of in vivo derived metabolites of [Pyr(1)]apelin-13 in humans. Sci Rep. 2019 Dec 27;9(1):19934. PubMed PMID: 31882594; PubMed Central PMCID:PMC6934825.
Oral EA, Gorden P, Cochran E, Araújo-Vilar D, Savage DB, Long A, Fine G, Salinardi T, Brown RJ. Long -term effectiveness and safety of metreleptin in the treatment of patients with partial lipodystrophy. Endocrine. 2019 Jun;64(3):500-511. doi: 10.1007/s12020-019-01862-8. PMID: 30805888 PMCID: PMC7340120
Ortega FJ, Moreno-Navarrete JM, Mercader JM, Gómez-Serrano M, García-Santos E, Latorre J, Lluch A, Sabater M, Caballano-Infantes E, Guzmán R, Macías-González M, Buxo M, Gironés J, Vilallonga R, Naon D, Botas P, Delgado E, Corella D, Burcelin R, Frühbeck G, Ricart W, Simó R, Castrillon-Rodríguez I, Tinahones FJ, Bosch F, Vidal-Puig A, Malagón MM, Peral B, Zorzano A, Fernández-Real JM. Cytoskeletal transgelin 2 contributes to gender-dependent adipose tissue expandability and immune function. FASEB J. 2019 Aug;33(8):9656-9671. PMID: 31145872.
O’Shea PM, O’Donoghue D, Bashari W, Senanayake R, Joyce MB, Powlson AS, Browne D, O’Sullivan GJ, Cheow H, Mendichovszky I, Quill D, Lowery A, Lappin D, Gurnell M, Dennedy MC. 11 C-Metomidate PET/CT is a useful adjunct for lateralization of primary aldosteronism in routine clinical practice. Clin Endocrinol (Oxf). 2019 May;90(5):670-679. doi: 10.1111/cen.13942. Epub 2019 Mar 18. PMID: 30721535
Parkinson JRC, Emsley R, Adkins JLT, Longford N, Ozanne SE, Holmes E, Modi N. Clinical and molecular evidence of accelerated ageing following very preterm birth. Pediatr Res. 2019 Dec 7. Epub ahead of print. PMID: 31812156.
Patel S, Alvarez-Guaita A, Melvin A, Rimmington D, Dattilo A, Miedzybrodzka EL, Cimino I, Maurin AC, Roberts GP, Meek CL, Virtue S, Sparks LM, Parsons SA, Redman LM, Bray GA, Liou AP, Woods RM, Parry SA, Jeppesen PB, Kolnes AJ, Harding HP, Ron D, Vidal-Puig A, Reimann F, Gribble FM, Hulston CJ, Farooqi IS, Fafournoux P, Smith SR, Jensen J, Breen D, Wu Z, Zhang BB, Coll AP, Savage DB, O’Rahilly S. GDF15 Provides an Endocrine Signal of Nutritional Stress in Mice and Humans. Cell Metab. 2019 Mar 5;29(3):707-718.e8. PMID: 30639358 PMCID: PMC6408327
Patel V, Bidault G, Chambers JE, Carobbio S, Everden AJT, Garcés C, Dalton LE, Gribble FM, VidalPuig A, Marciniak SJ. Inactivation of Ppp1r15a minimises weight gain and insulin resistance during caloric excess in female mice. Sci Rep. 2019 Feb 27;9(1):2903. doi: 10.1038/s41598-019-39562-y. PMID: 30814564 PMCID: PMC6393541
Peters C, Nicholas AK, Schoenmakers E, Lyons G, Langham S, Serra EG, Sebire NJ, Muzza M, Fugazzola L, Schoenmakers N. DUOX2/DUOXA2 Mutations Frequently Cause Congenital Hypothyroidism that Evades Detection on Newborn Screening in the United Kingdom. Thyroid. 2019 Jun;29(6):790-801. PMID:31044655; PMCID:PMC6588112
Petkevicius K, Virtue S, Bidault G, Jenkins B, Çubuk C, Morgantini C, Aouadi M, Dopazo J, Serlie MJ, Koulman A, Vidal-Puig A. Accelerated phosphatidylcholine turnover in macrophages promotes adipose tissue inflammation in obesity. Elife. 2019 Aug 16;8. PMID: 31418690.
Petry CJ, Ong KK, Hughes IA, Acerini CL, Dunger DB. Age at Menarche and Blood Pressure in Pregnancy. Pregnancy Hypertens. 2019 Jan;15:134-140. PMID: 30713829 PMCID: PMC6352955
Prats-Puig A, Xargay-Torrent S, Carreras-Badosa G, Mas-Parés B, Bassols J, Petry CJ, Girardot M, D E Zegher F, Ibáñez L, Dunger DB, Feil R, López-Bermejo A. Methylation of the C19MC microRNA locus in the placenta: association with maternal and chilhood body size. Int J Obes (Lond). 2019 Sep 25. [Epub ahead of print] PMID: 31554916.
Prentice PM, Olga L, Petry CJ, Simmons D, Murphy HR, Hughes IA, Acerini CL, Ong KK, Dunger DB. Reduced size at birth and persisting reductions in adiposity in recent, compared with earlier, cohorts of infants born to mothers with gestational diabetes mellitus. Diabetologia. 2019 Nov;62(11):1977-1987. Epub 2019 Aug 9. PubMed PMID: 31396660; PubMed Central PMCID: 6805804.
Prentice PM, Schoemaker MH, Vervoort J, Hettinga K, Lambers TT, van Tol EAF, Acerini CL, Olga L, Petry CJ, Hughes IA, Koulman A, Ong KK, Dunger DB. Human Milk Short-Chain Fatty Acid Composition is Associated with Adiposity Outcomes in Infants. J Nutr. 2019 May 1;149(5):716-722. PMID:31050748
Rana BMJ, Jou E, Barlow JL, Rodriguez-Rodriguez N, Walker JA, Knox C, Jolin HE, Hardman CS, Sivasubramaniam M, Szeto A, Cohen ES, Scott IC, Sleeman MA, Chidomere CI, Cruz Migoni S, Caamano J, Jorgensen HF, Carobbio S, Vidal-Puig A, McKenzie ANJ. A stromal cell niche sustains ILC2-mediated type-2 conditioning in adipose tissue. J Exp Med. 2019 Sep 2;216 (9):1999-2009. PMID: 31248899.
Razolli D, de Araújo T, Sant’Ana M, Kirwan P, Cintra D, Merkle F, Velloso L. POMC processing in the hypothalamus is directly regulated by saturated fat – implications for the development of obesity. Neuroendocrinology. 2019 May 20. [Epub ahead of print]. PMID: 31104058
Reimann F; Diakogiannaki E; Moss C E; Gribble F M. Cellular mechanisms governing Glucosedependent insulinotropic polypeptide secretion. Peptides. 2020 Mar;125:170206 170206. Epub 2019 Nov 19. Review. PubMed PMID: 31756367.
Riveros-McKay F, Mistry V, Bounds R, Hendricks A, Keogh JM, Thomas H, Henning E, Corbin LJ; Understanding Society Scientific Group, O’Rahilly S, Zeggini E, Wheeler E, Barroso I, Farooqi IS. Genetic architecture of human thinness compared to severe obesity. PLoS Genet. 2019 Jan 24;15(1):e1007603. PMID: 30677029 PMCID: PMC6345421
Roberts GP, Larraufie P, Richards P, Kay RG, Galvin SG, Miedzybrodzka EL, Leiter A, Li HJ, Glass LL, Ma MKL, Lam B, Yeo GSH, Scharfmann R, Chiarugi D, Hardwick RH, Reimann F, Gribble FM. Comparison of Human and Murine Enteroendocrine Cells by Transcriptomic and Peptidomic Profiling. Diabetes. 2019 May;68(5):1062-1072. doi: 10.2337/db18-0883. Epub 2019 Feb 7. PMID: 30733330 PMCID: PMC6477899
Ronan L, Alexander-Bloch A, Fletcher PC. Childhood Obesity, Cortical Structure, and Executive Function in Healthy Children. Cereb Cortex. 2019 Oct 24. [Epub ahead of print] PMID: 31646343.
Ruan Y, Willemsen RH, Wilinska ME, Tauschmann M, Dunger DB, Hovorka R. Mixed-meal tolerance test to assess residual beta-cell secretion: Beyond the area-under-curve of plasma C-peptide concentration. Pediatr Diabetes. 2019 May;20(3):282-285. doi: 10.1111/pedi.12816. PMID: 30652426 PMCID: PMC6487945
Savage DB, Watson L, Carr K, Adams C, Brage S, Chatterjee KK, Hodson L, Boesch C, Kemp GJ, Sleigh A. Accumulation of saturated intramyocellular lipid is associated with insulin resistance. J. Lipid Res. (2019) Jul;60(7):1323-1332. Epub 2019 May 2. PMID:31048405; PMCID:PMC6602127
Sefton C, Davies A, Allen TJ, Wray JR, Shoop R, Adamson A, Humphreys N, Coll AP, White A, Harno E. The metabolic abnormalities of chronic high dose glucocorticoids are not mediated by hypothalamic AgRP in male mice. Endocrinology. 2019 May 1;160(5):964-978. doi: 10.1210/en.2019-00018. PMID: 30794724 PMCID: PMC6444294
Schierloh U, Wilinska ME, Pit-Ten Cate IM, Baumann P, Hovorka R, De Beaufort C; Spidiman Study Group: Single Port Insulin Infusion for Improved Diabetes Management. Lower plasma insulin levels during overnight closed-loop in school children with type 1 diabetes: Potential advantage? A randomized cross-over trial. PLoS One. 2019 Mar 8;14(3):e0212013. doi: 10.1371/journal.pone.0212013. eCollection 2019. PMID: 30849076 PMCID: PMC6408001
Speight J, Holmes-Truscott E, Little SA, Leelarathna L, Walkinshaw E, Tan HK, Bowes A, Kerr D, Flanagan D, Heller SR, Evans ML, Shaw JAM. Satisfaction with the Use of Different Technologies for Insulin Delivery and Glucose Monitoring Among Adults with Long-Standing Type 1 Diabetes and Problematic Hypoglycemia: 2-Year Follow-Up in the HypoCOMPaSS Randomized Clinical Trial. Diabetes Technol Ther. 2019 Nov;21(11):619-626. PMID: 31335201.
Sutherland MJ, Camm EJ, Giussani DA, Ozanne SE. Chronic gestational hypoxia accelerates ovarian aging and lowers ovarian reserve in next-generation adult rats. FASEB J. 2019 Jun;33 (6):7758-7766. Epub 2019 Mar 19. PMID:30888848; PMCID:PMC6529349
Tarry-Adkins JL, Aiken CE, Ozanne SE. Neonatal, infant, and childhood growth following metformin versus insulin treatment for gestational diabetes: A systematic review and meta-analysis. PLoS Med. 2019 Aug 6;16(8):e1002848. PMID: 31386659.
Tarry-Adkins JL, Ozanne SE. Poor Early Growth and Age-Associated Disease. Subcell Biochem. 2019;91:1-19. PMID: 30888647
Tauschmann M, Allen JM, Nagl K, Fritsch M, Yong J, Metcalfe E, Schaeffer D, Fichelle M, Schierloh U, Thiele AG, Abt D, Kojzar H, Mader JK, Slegtenhorst S, Barber N, Wilinska ME, Boughton C, Musolino G, Sibayan J, Cohen N, Kollman C, Hofer SE, Fröhlich-Reiterer E, Kapellen TM, Acerini CL, de Beaufort C, Campbell F, Rami-Merhar B, Hovorka R; KidsAP Consortium. Home Use of Day-and-Night Hybrid Closed-Loop Insulin Delivery in Very Young Children: A Multicenter, 3-Week, Randomized Trial. Diabetes Care. 2019 Apr;42(4):594-600. doi: 10.2337/dc18-1881. Epub 2019 Jan 28. PMID: 30692242
Teulings NEWD, Masconi KL, Ozanne SE, Aiken CE, Wood AM. Effect of interpregnancy weight change on perinatal outcomes: systematic review and meta-analysis. BMC Pregnancy Childbirth. 2019 Oct 28;19(1):386. PMID: 31660893.
Thakar R, Gajewska-Knapik G, Ogilvy-Stuart AL, Chatterjee K, Moran C. Response to Letter to the Editor: “Alemtuzumab-induced thyroid dysfunction exhibits distinctive clinical and immunological features”. J.Clin. Endocrinol. Metab. (2019). PMID:30977836
Tschaikner M, Powell K, Jungklaus M, Fritz M, Ellmerer M, Hovorka R, Lane S, Pieber TR, Regittnig W. Novel Single-Site Device for Conjoined Glucose Sensing and Insulin Infusion: Performance Evaluation in Diabetes Patients During Home-Use. IEEE Trans Biomed Eng. 2019 Jun 27. [Epub ahead of print]. PMID:31251175
Turcot V, 39 authors, Barroso I, 65 authors, Farooqi IS, 293 authors, Loos RJF. Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity. Nat Genet. 2019 Jul;51(7):1191- 1192. PMID:31160809
van der Klaauw AA, Croizier S, Mendes de Oliveira E, Stadler LKJ, Park S, Kong Y, Banton MC, Tandon P, Hendricks AE, Keogh JM, Riley SE, Papadia S, Henning E, Bounds R, Bochukova EG, Mistry V, O’Rahilly S, Simerly RB; INTERVAL; UK10K Consortium, Minchin JEN, Barroso I, Jones EY, Bouret SG, Farooqi IS. Human Semaphorin 3 Variants Link Melanocortin Circuit Development and Energy Balance. Cell. 2019 Feb 7;176(4):729-742.e18. PMID: 30661757 PMCID: PMC6370916
Vargas-Castillo A, Tobon-Cornejo S, Del Valle-Mondragon L, Torre-Villalvazo I, SchcolnikCabrera A, Guevara-Cruz M, Pichardo-Ontiveros E, Fuentes-Romero R,Bader M, Alenina N, Vidal-Puig A, Hong E, Torres N, Tovar AR. Angiotensin-(1-7) induces beige fat thermogenesis through the Mas receptor. Metabolism. 2019 Dec 13;103:154048. Epub ahead of print. PubMed PMID: 31843339. PMCID: PMC7054746.
Vasiljevic M, Fuller G, Pilling M, Hollands GJ, Pechey R, Jebb SA, Marteau TM. What is the impact of increasing the prominence of calorie labelling? A stepped wedge randomised controlled pilot trial in worksite cafeterias. Appetite. 2019 Oct 1;141:104304. Epub 2019 May 29. PMID:31152762
Vergari E, Knudsen JG, Ramracheya R, Salehi A, Zhang Q, Adam J, Asterholm IW, Benrick A, Briant LJB, Chibalina MV, Gribble FM, Hamilton A, Hastoy B, Reimann F, Rorsman NJG, Spiliotis II, Tarasov A, Wu Y, Ashcroft FM, Rorsman P. Insulin inhibits glucagon release by SGLT2-induced stimulation of somatostatin secretion. Nat Commun. 2019 Jan 11;10(1):139. PMID: 30635569 PMCID: PMC6329806
Vestergaard ET, Hjelholt AJ, Kuhre RE, Møller N, Larraufie P, Gribble FM, Reimann F, Jessen N, Holst JJ, Jørgensen JOL. Acipimox Acutely Increases GLP-1 Concentrations in Overweight Subjects and Hypopituitary Patients. J Clin Endocrinol Metab. 2019 Jul 1;104(7):2581- 2592. PMID:30726969; PMCID:PMC7212086
Wallenius V, Elias E, Elebring E, et al. Suppression of enteroendocrine cell glucagon-like peptide (GLP)-1 release by fat-induced small intestinal ketogenesis: a mechanism targeted by Roux-enY gastric bypass surgery but not by preoperative very-low-calorie diet. Gut Published Online First: 21 November 2019. doi: 10.1136/gutjnl-2019-319372. PMID: 31753852.
Watson LPE, Carr KS, Venables MC, Acerini CL, Lyons G, Moran C, Murgatroyd PR, Chatterjee K. Quantifying energy expenditure in childhood: utility in managing pediatric metabolic disorders. Am J Clin Nutr. 2019 Nov 1;110(5):1186-1191. PMID: 31410443. PMCID: PMC6821543.
Wejaphikul K, Groeneweg S, Hilhorst-Hofstee Y, Chatterjee VK, Peeters RP, Meima ME, Visser WE. Insight into molecular determinants of T3 vs. T4 recognition from mutations in thyroid hormone receptor alpha and beta. J.Clin. Endocrinol. Metab. (2019). PMID:30817817; PMCID:PMC6599431
Westwater ML, Vilar-López R, Ziauddeen H, Verdejo-García A, Fletcher PC. Combined effects of age and BMI are related to altered cortical thickness in adolescence and adulthood. Dev Cogn Neurosci. 2019 Dec;40:100728. Epub 2019 Nov 5. PubMed PMID: 31751856; PubMed Central PMCID: PMC6913515.
Wieczorek A, Perani CV, Nixon M, Constancia M, Sandovici I, Zazara DE, Leone G, Zhang MZ, Arck PC, Solano ME. Sex-specific regulation of stress-induced fetal glucocorticoid surge by the mouse placenta. Am J Physiol Endocrinol Metab. 2019 Jul 1;317(1):E109-E120. Epub 2019 Apr 16. PMID:30990748
Wray JR, Davies A, Sefton C, Allen TJ, Adamson A, Chapman P, Lam BYH, Yeo GSH, Coll AP, Harno E, White A. Global transcriptomic analysis of the arcuate nucleus following chronic glucocorticoid treatment. Mol Metab. 2019 Aug;26:5-17. PubMed PMID: 31176677.
Yang Y, van der Klaauw AA, Zhu L, Cacciottolo TM, He Y, Stadler LKJ, Wang C, Xu P, Saito K, Hinton A Jr, Yan X, Keogh JM, Henning E, Banton MC, Hendricks AE, Bochukova EG, Mistry V, Lawler KL, Liao L, Xu J, O’Rahilly S, Tong Q; UK10K Consortium, Inês Barroso, O’Malley BW, Farooqi IS, Xu Y. Steroid receptor coactivator-1 modulates the function of Pomc neurons and energy homeostasis. Nat Commun. 2019 Apr 12;10(1):1718. PMID:30979869; PMCID:PMC6461669
Yeo SH, Kyle V, Blouet C, Jones S, Colledge WH. Mapping neuronal inputs to Kiss1 neurons in the arcuate nucleus of the mouse. PLoS One. 2019 Mar 27;14(3):e0213927. eCollection 2019. PMID:30917148; PMCID:PMC6436706
Ziegler AN, Feng Q, Chidambaram S, Testai JM, Kumari E, Rothbard DE, Constancia M, Sandovici I, Cominski T, Pang K, Gao N, Wood TL, Levison SW. Insulin-like Growth Factor II: An Essential Adult Stem Cell Niche Constituent in Brain and Intestine. Stem Cell Reports. 2019 Apr 9;12(4):816-830. doi: 10.1016/j.stemcr.2019.02.011. PMID: 30905741 PMCID: PMC6450461

2018

Adriaenssens AE, Reimann F, Gribble FM.Distribution and Stimulus Secretion Coupling of En- teroendocrine Cells along the Intestinal Tract. Compr Physiol. 2018 Sep 14;8(4):1603-1638.
Aprile M, Cataldi S, Ambrosio MR, D’Esposito V, Lim K, Dietrich A, Blüher M, Savage DB, Formisano P, Ciccodicola A, Costa V. PPARγΔ5, a Naturally Occurring Dominant-Negative Splice Isoform, Impairs PPARγ Function and Adipocyte Differentiation. Cell Rep. 2018 Nov 6;25 (6):1577-1592.e6. doi: 10.1016/j.celrep.2018.10.035.PMID:30404011
Bally L, Thabit H, Hovorka R. Closed-Loop Insulin for Glycemic Control in Noncritical Care. N Engl J Med. 2018 Nov 15;379(20):1970-1971. doi: 10.1056/NEJMc1811995. No abstract availa- ble. PMID:30428293
Bauzá-Thorbrügge M, Rodríguez-Cuenca S, Vidal-Puig A, Galmés-Pascual BM, Sbert-Roig M, Gianotti M, Lladó I, Proenza AM J. GPER and ERα mediate estradiol enhancement of mitochon- drial function in inflamed adipocytes through a PKA dependent mechanism. Steroid Biochem Mol Biol. 2018 Sep 22. pii: S0960-0760(18)30068-2. PMID:30253224
Beeson JH, Blackmore HL, Carr SK, Dearden L, Duque-Guimarães DE, Kusinski LC, Pantaleão LC, Pinnock AG, Aiken CE, Giussani DA, Fernandez-Twinn DS, Ozanne SE. Maternal exercise intervention in obese pregnancy improves the cardiovascular health of the adult male offspring. Mol Metab. 2018 Oct;16:35-44. PMID: 30293577.PMCID: PMC6157615
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Goldspink DA, Reimann F, Gribble FM. Models and Tools for Studying Enteroendocrine Cells. Endocrinology. 2018 Sep 14. doi: 10.1210/en.2018-00672. PMID:30239642
Harno E, Gali Ramamoorthy T, Coll AP, White A.POMC: The Physiological Power of Hormone Processing. Physiol Rev. 2018 Oct 1;98(4):2381-2430. PMID: 30156493PMCID: PMC6170974
Hendricks AE, Billups SC, Pike HNC, Farooqi IS, Zeggini E, Santorico SA, Barroso I, Dupuis J. ProxECAT: Proxy External Controls Association Test. A new case-control gene region associ- ation test using allele frequencies from public controls. PLoS Genet. 2018 Oct 16;14 (10):e1007591. PMID: 30325923PMCID: PMC6191077
Holt MK, Richards JE, Cook DR, Brierley DI, Williams DL, Reimann F, Gribble FM, Trapp S. Preproglucagon Neurons in the Nucleus of the Solitary Tract are the Main Source of Brain GLP-1, Mediate Stress-Induced Hypophagia, and Limit Unusually Large Intakes of Food. Diabe- tes. 2018 Oct 2. pii: db180729. PMID: 30279161PMCID: PMC6314470
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Kirwan P, Kay RG, Brouwers B, Herranz-Pérez V, Jura M, Larraufie P, Jerber J, Pembroke J, Bartels T, White A, Gribble FM, Reimann F, Farooqi IS, O’Rahilly S, Merkle FT. Quantitative mass spectrometry for human melanocortin peptides in vitro and in vivo suggests prominent roles for β-MSH and desacetyl α-MSH in energy homeostasis. Mol Metab. 2018 Nov;17:82-97. PMID: 30201275 PMCID: PMC6197775
Klonoff DC, Evans ML, Lane W, Kempe HP, Renard E, Hans DeVries J, Graungaard T, Hyseni A, Gondolf T, Battelino T. A randomized, multicentre trial evaluating the efficacy and safety of fast-acting insulin aspart in continuous subcutaneous insulin infusion in adults with type 1 diabe- tes (onset 5). Diabetes Obes Metab. 2018 Dec 9. doi: 10.1111/dom.13610. PMID:30537180
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Ouyang J, Hardy R, Brown M, Helliwell T, Gurnell M, Cuthbertson DJ. 11C-metomidate PET-CT scanning can identify aldosterone-producing adenomas after unsuccessful lateralisation with CT/MRI and adrenal venous sampling. J Hum Hypertens. 2017; 31:483-484.
Pestana D, Teixeira D, Meireles M, Marques C, Norberto S, Sá C, Fernandes VC, Correia-Sá L, Faria A, Guardão L, Guimarães JT, Cooper WN, Sandovici I, Domingues VF, Delerue-Matos C, Monteiro R, Constância M, Calhau C.Adipose tissue dysfunction as a central mechanism leading to dysmetabolic obesity triggered by chronic exposure to p,p’-DDE. Sci Rep. 2017; 7:2738.
Petry CJ, Mooslehner K, Prentice P, Hayes MG, Nodzenski M, Scholtens DM, Hughes IA, Acerini CL, Ong KK, Lowe WL Jr, Dunger DB. Associations between a fetal imprinted gene allele score and late pregnancy maternal glucose concentrations. Diabetes Metab. 2017. [Epub ahead of print]
Pompa A, De Marchis F, Pallotta MT, Benitez-Alfonso Y, Jones A, Schipper K, Moreau K, Žárský V, Di Sansebastiano GP, Bellucci M. Unconventional Transport Routes of Soluble and Membrane Proteins and Their Role in Developmental Biology. Int J Mol Sci. 2017; 18(4).
Psichas A, Tolhurst G, Brighton CA, Gribble FM, Reimann F. Mixed Primary Cultures of Murine Small Intestine Intended for the Study of Gut Hormone Secretion and Live Cell Imaging of Enteroendocrine Cells. J Vis Exp. 2017; 122:55687.
Rocha NM, [14 authors], Barroso I: 16, [10 authors], O’Rahilly SI: 27, [2 authors], Savage DB: 30, Semple RK Human biallelic MFN2 mutations induce mitochondrial dysfunction, upper body adipose hyperplasia, and suppression of leptin expression. eLife. 2017; 6: e23813.
Ruan Y, Thabit H, Leelarathna L, Hartnell S, Willinska ME, Tauschmann M, Dellweg S, Benesch C, Mader JK, Holzer M, Kojzar H, Evans ML, Pieber TR, Arnolds S, Hovorka R; AP@home consortium. Faster insulin action is associated with improved glycemic outcomes during closed-loop insulin delivery and sensor-augmented pump therapy in adults with type 1 diabetes. Diabetes Obes Metab. 2017. [Epub ahead of print]
Sferruzzi-Perri AN, Sandovici I, Constancia M, Fowden AL. Placental phenotype and the insulin-like growth factors: resource allocation to fetal growth. J Physiol. 2017; 595:5057-5093.
Taku N, Gurnell M, Burnet N, Jena R. Time dependence of radiation-induced hypothalamic-pituitary axis dysfunction in adults treated for non-pituitary, intracranial neoplasms. Clin Oncol (R Coll Radiol). 2017;29:34-41.
Teo AE, Garg S, Johnson TI, Zhao W, Zhou J, Gomez-Sanchez CE, Gurnell M, Brown MJ. Physiological and Pathological Roles in Human Adrenal of the Glomeruli-Defining Matrix Protein NPNT (Nephronectin). Hypertension. 2017; 69:1207-1216. Apr 17.
Thabit H, Hartnell S, Allen JM, Lake A, Wilinska ME, Ruan Y, Evans ML, Coll AP, Hovorka R. Closed-loop insulin delivery in inpatients with type 2 diabetes: a randomised, parallel-group trial. R.Lancet Diabetes Endocrinol. 2017; 5:117-124.
Tripolszki K, Farkas K, Sulák A, Szolnoky G, Duga B, Melegh B, Knox RG, Parker VER, Semple RK, Kemény L, Széll M, Nagy N. Atypical neurofibromatosis type 1 with unilateral limb hypertrophy mimicking overgrowth syndrome. Clin Exp Dermatol. 2017. [Epub ahead of print]
Tsoukalas M, Psichas A, Reimann F, Gribble FM, Lobstein A, Urbain A. Pregnane glycosides from Cynanchum menarandrense. Steroids. 2017; 125:27-32.
Tsuchiya Y, Peak-Chew S, Newell C, Miller-Aidoo S, Mangal S, Zhyvoloup A, Baković J, Malanchuk O, Pereira G, Kotiadis V, Szabadkai G, Duchen M, Campbell M, Rodriguez Cuenca S, Vidal-Puig A, James A, Murphy MP, Filonenko V, Skehel M, Gout I. Protein CoAlation: A Redox-Regulated Protein Modification by Coenzyme A in Mammalian Cells. Biochem J. 2017; 474:2489-2508.
van der Klaauw AA, Ziauddeen H, Keogh JM, Henning E, Dachi S, Fletcher PC, Farooqi IS Oxytocin administration suppresses hypothalamic activation in response to visual food cues. Sci Rep. 2017; 7:4266.eo CR, Agrawal M, Hoon S, Shabbir A, Shrivastava MK, Huang S, Khoo CM, Chhay V, Yassin MS, Tai ES, Vidal-Puig A, Toh SA. SGBS cells as a model of human adipocyte browning: A comprehensive comparative study with primary human white subcutaneous adipocytes. Sci Rep. 2017; 7:4031.
van Gucht ALM, Moran C, Meima ME, Visser WE, Chatterjee K, Visser TJ, Peeters RP. Resistance to Thyroid Hormone due to Heterozygous Mutations in Thyroid Hormone Receptor Alpha. Curr Top Dev Biol. 2017; 125:337-355.
Vasudevan P, Powell C, Nicholas AK, Scudamore I, Greening J, Park SM, Schoenmakers N. Intrauterine death following intraamniotic triiodothyronine and thyroxine therapy for fetal goitrous hypothyroidism associated with polyhydramnios and caused by a thyroglobulin mutation. Endocrinol Diabetes Metab Case Rep. 2017; 17-0040.
Wheeler SE, Stacey HM, Nahaei Y, Hale SJ, Hardy AB, Reimann F, Gribble FM, Larraufie P, Gaisano HY, Brubaker PL. The SNARE Protein, Syntaxin1a, Plays an Essential Role in Biphasic Exocytosis of the Incretin Hormone, Glucagon-Like Peptide-1. Diabetes. 2017; 66:2327-2338.
Yeo CR, Agrawal M, Hoon S, Shabbir A, Shrivastava MK, Huang S, Khoo CM, Chhay V, Yassin MS, Tai ES, Vidal-Puig A, Toh SA. SGBS cells as a model of human adipocyte browning: A comprehensive comparative study with primary human white subcutaneous adipocytes. Sci Rep. 2017: 7:4031.

2016

(* Open access publications)

Adriaenssens AE, Svendsen B, Lam BY, Yeo GS, Holst JJ, Reimann F, Gribble FM. Transcriptomic profiling of pancreatic alpha, beta and delta cell populations identifies delta cells as a principal target for ghrelin in mouse islets. Diabetologia 2016;59:2156-65. *
Ahmed RM, Irish M, Henning E, Dermody N, Bartley L, Kiernan MC, Piguet O, Farooqi S, Hodges JR. Assessment of eating behavior disturbance and associated neural networks in frontotemporal dementia. JAMA Neurol. 2016;73:282-90.
Aiken CE, Tarry-Adkins JL, Penfold NC, Dearden L, Ozanne SE. Decreased ovarian reserve, dysregulation of mitochondrial biogenesis, and increased lipid peroxidation in female mouse offspring exposed to an obesogenic maternal diet. FASEB J. 2016;30:1548-56. *
Alfaradhi MZ, Kusinski LC, Fernandez-Twinn DS, Pantaleão LC, Carr SK, Ferland-McCollough D, Yeo GS, Bushell M, Ozanne SE. Maternal obesity in pregnancy developmentally programs adipose tissue inflammation in young, lean male mice offspring. Endocrinology 2016;157:4246-56. *
Allison BJ, Kaandorp JJ, Kane AD, Camm EJ, Lusby C, Cross CM, Nevin-Dolan R, Thakor AS, Derks JB, Tarry-Adkins JL, Ozanne SE, Giussani DA. Divergence of mechanistic pathways mediating cardiovascular aging and developmental programming of cardiovascular disease. FASEB J. 2016;30:1968-75. *
Anesten F, Holt MK, Schéle E, Pálsdóttir V, Reimann F, Gribble FM, Safari C, Skibicka KP, Trapp S, Jansson JO. Preproglucagon neurons in the hindbrain have IL-6 receptor-α and show Ca2+ influx in response to IL-6. Am J Physiol Regul Integr Comp Physiol. 2016;311:R115-23. *
Baig S, Parvaresh Rizi E, Shabeer M, Chhay V, Mok SF, Loh TP, Magkos F, Vidal-Puig A, Tai ES, Khoo CM, Toh SA. Metabolic gene expression profile in circulating mononuclear cells reflects obesity-associated metabolic inflexibility. Nutr Metab (Lond). 2016;13:74. *
Boldt K, [54 authors], Group UKRD. An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. Nat Commun. 2016;7:11491. *
Breen DP, Nombela C, Vuono R, Jones PS, Fisher K, Burn DJ, Brooks DJ, Reddy AB, Rowe JB, Barker RA. Hypothalamic volume loss is associated with reduced melatonin output in Parkinson’s disease. Mov Disord. 2016;31:1062-6. *
Burberry A, [15 authors; Merkle FT: 9], Eggan K. Loss-of-function mutations in the C9ORF72 mouse ortholog cause fatal autoimmune disease. Sci Transl Med. 2016;8:347ra93. *
Burke LK, [17 authors], Evans ML, Heisler LK. Sex difference in physical activity, energy expenditure and obesity driven by a subpopulation of hypothalamic POMC neurons. Mol Metab. 2016;5:245-52. *
Carmody D, Ladsaria SS, Buikema RK, Semple RK, Greeley SAW. Successful rhIGF1 treatment for over 5 years in a patient with severe insulin resistance due to homozygous insulin receptor mutation. Diabet Med. 2016;33:e8-12. *
Castillo SD, [26 authors; Semple RK: 23], Vanhaesebroeck B. Somatic activating mutations in Pik3ca cause sporadic venous malformations in mice and humans. Sci Transl Med. 2016;8:332ra43.
Challis BG, Kandasamy N, Powlson AS, Koulouri O, Annamalai AK, Happerfield L, Marker AJ, Arends MJ, Nik-Zainal S, Gurnell M. Familial adrenocortical carcinoma in association with Lynch syndrome. J Clin Endocrinol Metab. 2016;101:2269-72. *
Challis BG, Lim CT, Cluroe A, Cameron E, O’Rahilly S. The McKittrick-Wheelock syndrome: a rare cause of curable diabetes. Endocrinol Diabetes Metab Case Rep. 2016;160013. *
Collet TH, van der Klaauw AA, Henning E, Keogh JM, Suddaby D, Dachi SV, Dunbar S, Kelway S, Dickson SL, Farooqi IS, Schmid SM. The sleep/wake cycle is directly modulated by changes in energy balance. Sleep 2016;39:1691-700. *
Correia-Melo C, [26 authors; Vidal-Puig A: 19], Passos JF. Mitochondria are required for pro-ageing features of the senescent phenotype. EMBO J. 2016;35:724-42.*
Dalgaard K, [28 authors; Yeo GS: 19, O’Rahilly S: 20, Coll AP: 27], Pospisilik JA. Trim28 haploinsufficiency triggers bi-stable epigenetic obesity. Cell 2016;164:353-64. *
Demir T, Onay H, Savage DB, Temeloglu E, Uzum AK, Kadioglu P, Altay C, Ozen S, Demir L, Cavdar U, Akinci B. Familial partial lipodystrophy linked to a novel peroxisome proliferator activator receptor -γ (PPARG) mutation, H449L: a comparison of people with this mutation and those with classic codon 482 Lamin A/C (LMNA) mutations. Diabet Med. 2016;33:1445-50.
Dennedy MC, Annamalai AK, Prankerd Smith O, Freeman N, Vengopal K, Graggaber J, Koulouri O, Powlson AS, Shaw A, Halsall DJ, Gurnell M. Low DHEAS: a sensitive and specific test for detection of subclinical hypercortisolism in adrenal incidentalomas. J Clin Endocrinol Metab. 2016;jc20162718.
Diederen KM, Spencer T, Vestergaard MD, Fletcher PC, Schultz W. Adaptive prediction error coding in the human midbrain and striatum facilitates behavioural adaptation and learning efficiency. Neuron. 2016;90:1127-38. doi: *
Duque-Guimarães DE, de Almeida-Faria J, Ong TP, Ozanne SE. Pulsed SILAC as a approach for miRNA targets identification in cell culture. Methods Mol Biol. 2017;1546:149-59.
Dusaulcy R, Handgraaf S, Heddad-Masson M, Visentin F, Vesin C, Reimann F, Gribble F, Philippe J, Gosmain Y. α-cell dysfunctions and molecular alterations in male insulinopenic diabetic mice are not completely corrected by insulin. Endocrinology 2016;157:536-47.
Edgar RS, Stangherlin A, Nagy AD, Nicoll MP, Efstathiou S, O’Neill JS, Reddy AB. Cell autonomous regulation of herpes and influenza virus infection by the circadian clock. Proc Natl Acad Sci USA. 2016;113:10085-90. *
Ekberg JH, [14 authors; Gribble FM: 10, Reiman F: 11], Schwartz TW. GPR119, a major enteroendocrine sensor of dietary triglyceride metabolites coacting in synergy With FFA1 (GPR40). Endocrinology 2016;157:4561-9.
Farrington C, Allen J, Tauschmann M, Randell T, Trevelyan N, Hovorka R. Factors affecting recruitment of participants for studies of diabetes technology in newly diagnosed youth with type 1 diabetes: a qualitative focus group study with parents and children. Diabetes Technol Ther. 2016;18:568-73. *
Flint TR, Janowitz T, Connell CM, Roberts EW, Denton AE, Coll AP, Jodrell DI, Fearon DT. Tumor-induced IL-6 reprograms host metabolism to suppress anti-tumor immunity. Cell Metab. 2016;24:672-84. *
Fuchsberger C, [301 authors; O’Rahilly SP: 208], McCarthy MI. The genetic architecture of type 2 diabetes. Nature 2016;536:41-7. *
Gathercole LL, [13 authors; Semple RK: 11], Geberhiwot T. Advanced non-alcoholic fatty liver disease and adipose tissue fibrosis in patients with Alström syndrome. Liver Int. 2016;36:1704-12.
Giraud K, Pontin M, Sharples LD, Fletcher P, Dalgleish T, Eden A, Jenkins DP, Vuylsteke A. Use of a structured mirrors intervention does not reduce delirium incidence but may improve factual memory encoding in cardiac surgical ICU patients aged over 70 years: a pilot time-cluster randomized controlled trial. Front Aging Neurosci. 2016;8:228.
Gripp KW, Baker L, Kandula V, Conard K, Scavina M, Napoli JA, Griffin GC, Thacker M, Knox RG, Clark GR, Parker VER, Semple R, Mirzaa G, Keppler-Noreuil KM. Nephroblastomatosis or Wilms tumor in a fourth patient with a somatic PIK3CA mutation. Am J Med Genet A. 2016;170:2559-69.
Groeneveld MP, Brierley GV, Rocha NM, Siddle K, Semple RK. Acute knockdown of the insulin receptor or its substrates Irs1 and 2 in 3T3-L1 adipocytes suppresses adiponectin production. Sci Rep. 2016 Feb 18;6:21105. *
Hall Z, Bond NJ, Ashmore T, Sanders F, Ament Z, Wang X, Murray AJ, Bellafante E, Virtue S, Vidal-Puig A, Allison M, Davies SE, Koulman A, Vacca M, Griffin JL. Lipid zonation and phospholipid remodeling in nonalcoholic fatty liver disease. Hepatology 2016;epub ahead of print.
Heppolette CA, Chen JH, Carr SK, Palmer DB, Ozanne SE. The effects of aging and maternal protein restriction during lactation on thymic involution and peripheral immunosenescence in adult mice. Oncotarget 2016;7:6398-409. *
Holland ML, Lowe R, Caton PW, Gemma C, Carbajosa G, Danson AF, Carpenter AA, Loche E, Ozanne SE, Rakyan VK. Early-life nutrition modulates the epigenetic state of specific rDNA genetic variants in mice. Science 2016;353:495-8.
Hollands GJ, Marteau TM, Fletcher PC. Non-conscious processes in changing health-related behaviour: a conceptual analysis and framework. Health Psychol Rev. 2016;10:381-394. *
Huang-Doran I, [18 authors], Savage DB, Murphy R, O’Rahilly S, Barroso I, Semple RK. Insulin resistance uncoupled from dyslipidemia due to C-terminal PIK3R1 mutations. JCI Insight. 2016;1:e88766. *
Inman M, Daneman D, Curtis J, Sochett E, Elia Y, Dunger DB, Deanfield J, Mahmud FH. Assessing social determinants of health in a pediatric diabetes clinical research trial: Are recruited subjects representative of the larger clinical population? Diabetes Res Clin Pract. 2016;113:41-3.
Joustra SD, Heinen CA, Schoenmakers N, Bonomi M, Ballieux BEPB, Turgeon MO, Bernard DJ, Fliers E, van Trotsenburg ASP, Losekoot M, Persani L, Wit JM, Biermasz NR, Pereira AM, Oostdijk W, Group ICC. IGSF1 deficiency: lessons from an extensive case series and recommendations for clinical management. J Clin Endocrinol Metab. 2016;101:1627-36. *
Joustra SD, Schoenmakers N, [26 authors; Chatterjee K: 22], van Trotsenburg AS. The IGSF1 deficiency syndrome: characteristics of male and female patients. J Clin Endocrinol Metab. 2013;98:4942-52.
Kandasamy N, Garfinkel SN, Page L, Hardy B, Critchley HD, Gurnell M, Coates JM. Interoceptive ability predicts survival on a London trading floor. Sci Rep. 2016;6:32986. *
Kilpeläinen TO, [175 authors; Savage DB: 99], Loos RJ. Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels. Nat Commun. 2016;7:10494. *
Kim HS, [15 authors; Yeo GS: 9], Lee MG. A coding variant in FTO confers susceptibility to thiopurine-induced leukopenia in East Asian patients with IBD. Gut 2016;pii:gutjnl-2016-311921.
Koulouri O, Hoole AC, English P, Allinson K, Antoun N, Cheow H, Burnet NG, Donnelly N, Mannion RJ, Gurnell M. Localisation of an occult thyrotropinoma with (11)C-methionine PET-CT before and after somatostatin analogue therapy. Lancet Diabetes Endocrinol. 2016;4:1050.
Koulouri O, [28 authors], Gurnell M. Successful treatment of residual pituitary adenoma in persistent acromegaly following localisation by 11C-methionine PET co-registered with MRI. Eur J Endocrinol. 2016;175:485-98.
Koulouri O, Nicholas AK, Schoenmakers E, Mokrosinski J, Lane F, Cole T, Kirk J, Farooqi IS, Chatterjee VK, Gurnell M, Schoenmakers N. A novel thyrotropin-releasing hormone receptor missense mutation (P81R) in central congenital hypothyroidism. J Clin Endocrinol Metab. 2016;101:847-51. *
Kuhre RE, Wewer Albrechtsen NJ, Deacon CF, Balk-Møller E, Rehfeld JF, Reimann F, Gribble FM, Holst JJ. Peptide production and secretion in GLUTag, NCI-H716, and STC-1 cells: a comparison to native L-cells. J Mol Endocrinol. 2016;56:201-11.
Langeveld M, Tan CY, Soeters MR, Virtue S, Ambler GK, Watson LP, Murgatroyd PR, Chatterjee VK, Vidal-Puig A. Mild cold effects on hunger, food intake, satiety and skin temperature in humans. Endocr Connect. 2016;5:65-73. *
Leelarathna L, Thabit H, Hartnell S, Willinska ME, Dellweg S, Benesch C, Mader JK, Holzer M, Kojzar H, Evans ML, Arnolds S, Pieber TR, Hovorka R, AP@home Consortium. Rapid benefits of structured optimization and sensor-augmented insulin pump therapy in adults with type 1 diabetes. J Diabetes Sci Technol. 2016;pii:1932296816654715.
Lie S, Morrison JL, Williams-Wyss O, Suter CM, Humphreys DT, Ozanne SE, Zhang S, MacLaughlin SM, Kleemann DO, Walker SK, Roberts CT, McMillen IC. Impact of maternal undernutrition around the time of conception on factors regulating hepatic lipid metabolism and microRNAs in singleton and twin fetuses. Am J Physiol Endocrinol Metab. 2016;310:E148-59. *
Lotta LA, [26 authors; O’Rahilly S: 25], Langenberg C. Genetic predisposition to an impaired metabolism of the branched-chain amino acids and risk of type 2 diabetes: a mendelian randomisation analysis. PLoS Med. 2016;13:e1002179. *
Lotta LA, [39 authors; O’Rahilly S: 35], Wareham NJ. Association between low-density lipoprotein cholesterol-lowering genetic variants and risk of type 2 diabetes: a meta-analysis. JAMA 2016;316:1383-91.
Lu L, Koulman A, Petry CJ, Jenkins B, Matthews L, Hughes IA, Acerini CL, Ong KK, Dunger DB. An unbiased lipidomics approach identifies early second trimester lipids predictive of maternal glycemic traits and gestational diabetes mellitus. Diabetes Care 2016;39:2232-9. *
Maahs DM, [22 authors; Hovorka R: 11], Lum JW. Outcome Measures for Artificial Pancreas Clinical Trials: A Consensus Report. Diabetes Care 2016;39:1175-9.
Majithia AR, [24 authors, O’Rahilly S: 19], Altshuler D. Prospective functional classification of all possible missense variants in PPARG. Nat Genet. 2016;48:1570-5. *
Manning KE, McAllister CJ, Ring HA, Finer N, Kelly CL, Sylvester KP, Fletcher PC, Morrell NW, Garnett MR, Manford MR, Holland AJ. Novel insights into maladaptive behaviours in Prader-Willi syndrome: serendipitous findings from an open trial of vagus nerve stimulation. J Intellect Disabil Res. 2016;60:149-55. *
Marelli F, Carra S, Agostini M, Cotelli F, Peeters R, Chatterjee K, Persani L. Patterns of thyroid hormone receptor expression in zebrafish and generation of a novel model of resistance to thyroid hormone action. Mol Cell Endocrinol. 2016;424:102-17.
Martin-Gronert MS, Fernandez-Twinn DS, Bushell M, Siddle K, Ozanne SE. Cell-autonomous programming of rat adipose tissue insulin signalling proteins by maternal nutrition. Diabetologia 2016;59:1266-75. *
Martin-Gronert MS, Stocker CJ, Wargent ET, Cripps RL, Garfield AS, Jovanovic Z, D’Agostino G, Yeo GS, Cawthorne MA, Arch JR, Heisler LK, Ozanne SE. 5-HT2A and 5-HT2C receptors as hypothalamic targets of developmental programming in male rats. Dis Model Mech. 2016;9:401-12.*
Martínez R, Kapravelou G, Porres JM, Melesio AM, Heras L, Cantarero S, Gribble FM, Parker H, Aranda P, López-Jurado M. Medicago sativa L, a functional food to relieve hypertension and metabolic disorders in a spontaneously hypertensive rat model. Journal of Functional Foods 2016;26:470-84.
Medic N, Ziauddeen H, Ersche KD, Farooqi IS, Bullmore ET, Nathan PJ, Ronan L, Fletcher PC. Increased body mass index is associated with specific regional alterations in brain structure. Int J Obes (Lond). 2016;40:1177-82. *
Medic N, Ziauddeen H, Forwood SE, Davies KM, Ahern AL, Jebb SA, Marteau TM, Fletcher PC. The presence of real food usurps hypothetical health value judgment in overweight people. 2016;3.pii: ENEURO.0025-16.2016. *
Meek CL, Lewis HB, Vergese B, Park A, Reimann F, Gribble F. The effect of encapsulated glutamine on gut peptide secretion in human volunteers. Peptides 2016;77:38-46. *
Morton NM, [31 authors; Vidal-Puig A: 29], Horvat S. Genetic identification of thiosulfate sulfurtransferase as an adipocyte-expressed antidiabetic target in mice selected for leanness. Nat Med. 2016;22:771-9.
Moss CE, Glass LL, Diakogiannaki E, Pais R, Lenaghan C, Smith DM, Wedin M, Bohlooly-Y M, Gribble FM, Reimann F. Lipid derivatives activate GPR119 and trigger GLP-1 secretion in primary murine L-cells. Peptides 2016 Mar;77:16-20. *
Musial B, Fernandez-Twinn DS, Vaughan OR, Ozanne SE, Voshol P, Sferruzzi-Perri AN, Fowden AL. Proximity to delivery alters insulin sensitivity and glucose metabolism in pregnant mice. Diabetes 2016;65:851-60. *
Neupane S, Peverall R, Richmond G, Blaikie TP, Taylor D, Hancock G, Evans ML. Exhaled breath isoprene rises during hypoglycemia in type 1 diabetes. Diabetes Care 2016;39:e97-8.
Nicholas AK, [33 authors], Chatterjee VK, Anderson CA, Schoenmakers N. Comprehensive screening of eight known causative genes in congenital hypothyroidism with gland-in-situ. J Clin Endocrinol Metab. 2016;101:4521-31. *
Nicholas AK, Jaleel S, Lyons G, Schoenmakers E, Dattani MT, Crowne E, Bernhard B, Kirk J, Roche EF, Chatterjee VK, Schoenmakers N. Molecular spectrum of TSHβ subunit gene defects in central hypothyroidism in the UK and Ireland. Clin Endocrinol (Oxf). 2016; Epub ahead of print.
Novoselova TV, Larder R, Rimmington D, Lelliott C, Wynn EH, Gorrigan RJ, Tate PH, Guasti L; Sanger Mouse Genetics Project, O’Rahilly S, Clark AJ, Logan DW, Coll AP, Chan LF. Loss of Mrap2 is associated with Sim1 deficiency and increased circulating cholesterol. J Endocrinol. 2016;230:13-26. *
Overduin J, Collet TH, Medic N, Henning E, Keogh JM, Forsyth F, Stephenson C, Kanning MW, Ruijschop RM, Farooqi IS, van der Klaauw AA. Failure of sucrose replacement with the non-nutritive sweetener erythritol to alter GLP-1 or PYY release or test meal size in lean or obese people. Appetite 2016;107:596-603. *
Pais R, Gribble FM, Reimann F. Signalling pathways involved in the detection of peptones by murine small intestinal enteroendocrine L-cells. Peptides 2016;77:9-15. *
Pais R, Rievaj J, Larraufie P, Gribble F, Reimann F. Angiotensin II type 1 receptor-dependent GLP-1 and PYY secretion in mice and humans. Endocrinology 2016;157:3821-3831. *
Pais R, Rievaj J, Meek C, De Costa G, Jayamaha S, Alexander RT, Reimann F, Gribble F. Role of enteroendocrine L-cells in arginine vasopressin-mediated inhibition of colonic anion secretion. J Physiol. 2016;594:4865-78. *
Parvaresh Rizi E, Baig S, Shabeer M, Teo Y, Mok SF, Loh TP, Magkos F, Virtue S, Vidal-Puig A, Tai ES, Khoo CM, Toh SA. Meal rich in carbohydrate, but not protein or fat, reveals adverse immunometabolic responses associated with obesity. Nutr J. 2016;15:100. *
Pauliina Markkula S, Lyons D, Yueh CY, Riches C, Hurst P, Fielding B, Heisler LK, Evans ML. Intracerebroventricular catalase reduces hepatic insulin sensitivity and increases responses to hypoglycemia in rats. Endocrinology 2016;157:4669-76. *
Petry CJ, Sanz Marcos N, Pimentel G, Hayes MG, Nodzenski M, Scholtens DM, Hughes I A, Acerini CL, Ong KK, Lowe WL, Dunger DB. Associations between fetal imprinted genes and maternal blood pressure in pregnancy. Hypertension 2016;68:1459-66.
Powlson AS, Challis BG, Halsall DJ, Schoenmakers E, Gurnell M. Nephrogenic syndrome of inappropriate antidiuresis secondary to an activating mutation in the arginine vasopressin receptor AVPR2. Clin Endocrinol (Oxf). 2016;85:306-12.
Pozzilli P, Battelino T, Danne T, Hovorka R, Jarosz-Chobot P, Renard E. Continuous subcutaneous insulin infusion in diabetes: patient populations, safety, efficacy, and pharmacoeconomics. Diabetes Metab Res Rev. 2016;32:21-39. *
Psichas A, Glass LL, Sharp SJ, Reimann F, Gribble FM. Galanin inhibits GLP-1 and GIP secretion via the GAL1 receptor in enteroendocrine L and K cells. Br J Pharmacol. 2016;173:888-98. *
Raffan E, [19 authors], Yeo GS, O’Rahilly S. A deletion in the canine POMC Gene is associated with weight and appetite in obesity-prone Labrador Retriever dogs. Cell Metab. 2016;23:893-900. *
Rahbari R, Wuster A, Lindsay SJ, Hardwick RJ, Alexandrov LB, Al Turki S, Dominiczak A, Morris A, Porteous D, Smith B, Stratton MR, UK10K Consortium, Hurles ME. Timing, rates and spectra of human germline mutation. Nat Genet. 2016;48:126-33. *
Rey G, Valekunja UK, Feeney KA, Wulund L, Milev NB, Stangherlin A, Ansel-Bollepalli L, Velagapudi V, O’Neill JS, Reddy AB. The pentose phosphate pathway regulates the circadian clock. Cell Metab. 2016;24:462-73. *
Richards P, Pais R, Habib AM, Brighton CA, Yeo GS, Reimann F, Gribble FM. High fat diet impairs the function of glucagon-like peptide-1 producing L-cells. Peptides 2016;77:21-7. *
Rodriguez-Cuenca S, Whyte L, Hagen R, Vidal-Puig A, Fuller M. Stearoyl-CoA Desaturase 1 is a key determinant of membrane lipid composition in 3T3-L1 adipocytes. PLoS One 2016;11:e0162047. *
Ronan L, Alexander-Bloch AF, Wagstyl K, Farooqi S, Brayne C, Tyler LK; Cam-CAN, Fletcher PC. Obesity associated with increased brain age from midlife. Neurobiol Aging. 2016;47:63-70. *
Rowe ER, Mimmack ML, Barbosa AD, Haider A, Isaac I, Ouberai MM, Thiam AR, Patel S, Saudek V, Siniossoglou S, Savage DB. Conserved amphipathic helices mediate lipid droplet targeting of perilipins 1-3. J Biol Chem. 2016;291:6664-78. *
Ruan Y, [12 authors], Hovorka R, AP@home Consortium. Variability of insulin requirements over 12 weeks of closed-loop insulin delivery in adults with type 1 diabetes. Diabetes Care 2016;39:830-2.
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