Publications - Wellcome-MRC Institute of Metabolic Science

Primary Research Publications

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2023

Adriaenssens A, Broichhagen J, de Bray A, Ast J, Hasib A, Jones B, Tomas A, Burgos NF, Woodward O, Lewis J, O’Flaherty E, El K, Cui C, Harada N, Inagaki N, Campbell J, Brierley D, Hodson DJ, Samms R, Gribble F, Reimann F. Hypothalamic and brainstem glucose-dependent insulinotropic polypeptide receptor neurons employ distinct mechanisms to affect feeding. JCI Insight. 2023 May 22;8(10):e164921. doi: 10.1172/jci.insight.164921. PMID:37212283
Ahluwalia R, Baldeweg SE, Boelaert K, Chatterjee K, Dayan C, Okosieme O, Priestley J, Taylor P, Vaidya B, Zammitt N, Pearce SH. Use of liothyronine (T3) in hypothyroidism: Joint British Thyroid Association/Society for endocrinology consensus statement. Clin Endocrinol (Oxf). 2023 Jun 5. doi: 10.1111/cen.14935. PMID:37272400
Al-Sawaf O, Weiss J, Skrzypski M, Lam JM, Karasaki T, Zambrana F, Kidd AC, Frankell AM, Watkins TBK, Martínez-Ruiz C, Puttick C, Black JRM, Huebner A, Bakir MA, Sokač M, Collins S, Veeriah S, Magno N, Naceur-Lombardelli C, Prymas P, Toncheva A, Ward S, Jayanth N, Salgado R, Bridge CP, Christiani DC, Mak RH, Bay C, Rosenthal M, Sattar N, Welsh P, Liu Y, Perrimon N, Popuri K, Beg MF, McGranahan N, Hackshaw A, Breen DM, O’Rahilly S, Birkbak NJ, Aerts HJWL; TRACERx Consortium; Jamal-Hanjani M, Swanton C. Body composition and lung cancer-associated cachexia in TRACERx. Nat Med. 2023 Apr;29(4):846-858. doi: 10.1038/s41591-023-02232-8. PMID:37045997 PMCID:PMC7614477
Alwan H, Ware J, Boughton CK, Wilinska ME, Allen JM, Lakshman R, Nwokolo M, Hartnell S, Bally L, de Beaufort C, Besser REJ, Campbell FM, Davis N, Denvir L, Evans ML, Fröhlich-Reiterer E, Ghatak A, Hofer SE, Kapellen TM, Leelarathna L, Mader JK, Narendran P, Rami-Mehrar B, Tauschmann M, Thabit H, Thankamony A, Hovorka R. Time Spent in Hypoglycemia According to Age and Time of Day: Observations During Closed-Loop Insulin Delivery. Diabetes Technol Ther. 2023 Jun 13. doi: 10.1089/dia.2023.0061. PMID:37229591
Alwan H, Wilinska ME, Ruan Y, Da Silva J, Hovorka R. Real-World Evidence Analysis of a Hybrid Closed-Loop System. J Diabetes Sci Technol. 2023 Jul 8:19322968231185348. doi: 10.1177/19322968231185348. PMID:37421250
Amin A, Badenes M, Tüshaus J, de Carvalho É, Burbridge E, Faísca P, Trávníčková K, Barros A, Carobbio S, Domingos PM, Vidal-Puig A, Moita LF, Maguire S, Stříšovský K, Ortega FJ, Fernández-Real JM, Lichtenthaler SF, Adrain C. Semaphorin 4B is an ADAM17-cleaved adipokine that inhibits adipocyte differentiation and thermogenesis. Mol Metab. 2023 Jul;73:101731. doi: 10.1016/j.molmet.2023.101731. PMID:37121509 PMCID:PMC10197113
Annamalai AK, Hemamalini R, Gurnell M. Bilateral enlarged ovarian masses and hypothyroidism. Eur J Intern Med. 2023 Mar 12:S0953-6205(23)00077-8. doi: 10.1016/j.ejim.2023.03.011. PMID:36918319
Annamalai AK, Srinivasan KG, Gurnell M. Secondary amenorrhoea with absent axillary hair. Eur J Intern Med. 2023 Mar 11:S0953-6205(23)00082-1. doi: 10.1016/j.ejim.2023.03.009. PMID:36914538
Asami M, Lam BYH, Hoffmann M, Suzuki T, Lu X, Yoshida N, Ma MK, Rainbow K, Gužvić M, VerMilyea MD, Yeo GSH, Klein CA, Perry ACF. A program of successive gene expression in mouse one-cell embryos. Cell Rep. 2023 Jan 31;42(2):112023. doi: 10.1016/j.celrep.2023.112023. PMID:36729835
Aye CC, Hammond DE, Rodriguez-Cuenca S, Doherty MK, Whitfield PD, Phelan MM, Yang C, Perez-Perez R, Li X, Diaz-Ramos A, Peddinti G, Oresic M, Vidal-Puig A, Zorzano A, Ugalde C, Mora S. CBL/CAP Is Essential for Mitochondria Respiration Complex I Assembly and Bioenergetics Efficiency in Muscle Cells. Int J Mol Sci. 2023 Feb 8;24(4):3399. doi: 10.3390/ijms24043399. PMID:36834818 PMCID:PMC9964740
Bano A, Laimer M, Wehrli F, Kunzler J, Rivero T, Fraser AG, Stettler C, Hovorka R, Bally L. Clinical evidence for high-risk medical devices used to manage diabetes: protocol for a systematic review and meta-analysis. BMJ Open. 2023 Apr 11;13(4):e070672. doi: 10.1136/bmjopen-2022-070672. PMID:37041065 PMCID:PMC10106051
Bany Bakar R, Reimann F, Gribble FM. The intestine as an endocrine organ and the role of gut hormones in metabolic regulation. Nat Rev Gastroenterol Hepatol. 2023 Aug 25. doi: 10.1038/s41575-023-00830-y. PMID:37626258
Becetti I, Bwenyi EL, de Araujo IE, Ard J, Cryan JF, Farooqi IS, Ferrario CR, Gluck ME, Holsen LM, Kenny PJ, Lawson EA, Lowell BB, Schur EA, Stanley TL, Tavakkoli A, Grinspoon SK, Singhal V. The Neurobiology of Eating Behavior in Obesity: Mechanisms and Therapeutic Targets: A Report from the 23rd Annual Harvard Nutrition Obesity Symposium. Am J Clin Nutr. 2023 May 4:S0002-9165(23)48896-X. doi: 10.1016/j.ajcnut.2023.05.003. PMID:37149092
Boughton CK, Hartnell S, Hobday N, Lake A, Davenport K, Daly A, Ward C, Taylor C, Hovorka R, Bansiya V. Implementation of fully closed-loop insulin delivery for inpatients with diabetes: Real-world outcomes. Diabet Med. 2023 Jun;40(6):e15092. doi: 10.1111/dme.15092. PMID:36947090
Boughton CK, Hartnell S, Lakshman R, Nwokolo M, Wilinska ME, Ware J, Allen JM, Evans ML, Hovorka R. Fully Closed-Loop Glucose Control Compared With Insulin Pump Therapy With Continuous Glucose Monitoring in Adults With Type 1 Diabetes and Suboptimal Glycemic Control: A Single-Center, Randomized, Crossover Study. Diabetes Care. 2023 Aug 24:dc230728. doi: 10.2337/dc23-0728. PMID:37616583
Broadaway KA, Yin X, Williamson A, Parsons VA, Wilson EP, Moxley AH, Vadlamudi S, Varshney A, Jackson AU, Ahuja V, Bornstein SR, Corbin LJ, Delgado GE, Dwivedi OP, Silva LF, Frayling TM, Grallert H, Gustafsson S, Hakaste L, Hammar U, Herder C, Herrmann S, Højlund K, Hughes DA, Kleber ME, Lindgren CM, Liu CT, Luan J, Malmberg A, Moissl AP, Morris AP, Perakakis N, Peters A, Petrie JR, Roden M, Schwarz PEH, Sharma S, Silveira A, Strawbridge RJ, Tuomi T, Wood AR, Wu P, Zethelius B, Baldassarre D, Eriksson JG, Fall T, Florez JC, Fritsche A, Gigante B, Hamsten A, Kajantie E, Laakso M, Lahti J, Lawlor DA, Lind L, März W, Meigs JB, Sundström J, Timpson NJ, Wagner R, Walker M, Wareham NJ, Watkins H, Barroso I, O’Rahilly S, Grarup N, Parker SC, Boehnke M, Langenberg C, Wheeler E, Mohlke KL. Loci for insulin processing and secretion provide insight into type 2 diabetes risk. Am J Hum Genet. 2023 Feb 2;110(2):284-299.doi: 10.1016/j.ajhg.2023.01.002. PMID:36693378
Brown DW, Cato LD, Zhao Y, Nandakumar SK, Bao EL, Gardner EJ, Hubbard AK, DePaulis A, Rehling T, Song L, Yu K, Chanock SJ, Perry JRB, Sankaran VG, Machiela MJ. Shared and distinct genetic etiologies for different types of clonal hematopoiesis. Nat Commun. 2023 Sep 8;14(1):5536. doi: 10.1038/s41467-023-41315-5. PMID:37684235
Brown SSG, Westwater ML, Seidlitz J, Ziauddeen H, Fletcher PC. Hypothalamic volume is associated with body mass index. Neuroimage Clin. 2023;39:103478. doi: 10.1016/j.nicl.2023.103478. PMID:37558541 PMCID:PMC10509524
Buller S, Kohnke S, Hansford R, Shimizu T, Richardson WD, Blouet C. Median eminence myelin continuously turns over in adult mice. Mol Metab. 2023 Feb 3;101690. doi: 10.1016/j.molmet.2023.101690. PMID:36739968
Carobbio S, Vidal-Puig A. Differentiation of Human Pluripotent Stem Cells (hPSCs) into Brown-Like Adipocytes. Methods Mol Biol. 2023;2662:1-9. doi: 10.1007/978-1-0716-3167-6_1. PMID:37076666
Castellá M, Blasco-Roset A, Peyrou M, Gavaldà-Navarro A, Villarroya J, Quesada-López T, Lorente-Poch L, Sancho J, Szymczak F, Piron A, Rodríguez-Fernández S, Carobbio S, Goday A, Domingo P, Vidal-Puig A, Giralt M, Eizirik DL, Villarroya F, Cereijo R. Adipose tissue plasticity in pheochromocytoma patients suggests a role of the splicing machinery in human adipose browning. iScience. 2023 May 9;26(6):106847. doi: 10.1016/j.isci.2023.106847. PMID:37250773 PMCID: PMC10209542
Chen HC, Mazzaferro S, Tian T, Mali I, Merkle FT. Differentiation, Transcriptomic Profiling, and Calcium Imaging of Human Hypothalamic Neurons. Curr Protoc. 2023 Jun;3(6):e786. doi: 10.1002/cpz1.786. PMID:37272700
Daly AB, Boughton CK, Nwokolo M, Hartnell S, Wilinska ME, Cezar A, Evans ML, Hovorka R. Fully automated closed-loop insulin delivery in adults with type 2 diabetes: an open-label, single-center, randomized crossover trial. Nat Med. 2023 Jan;29(1):203-208. PMID:36631592
Dearden L, Ozanne SE. Early life impacts of maternal obesity: a window of opportunity to improve the health of two generations. Philos Trans R Soc Lond B Biol Sci. 2023 Sep 11;378(1885):20220222. doi: 10.1098/rstb.2022.0222. PMID:37482780 PMCID:PMC10363703
Dearden L, Ozanne SE. Considerations for designing and analysing inter-generational studies in rodents. Nat Metab. 2023 Jan;5(1):1-4. doi: 10.1038/s42255-022-00721-7. PMID:36609721
Dore R, Watson L, Hollidge S, Krause C, Sentis SC, Oelkrug R, Geißler C, Johann K, Pedaran M, Lyons G, Lopez-Alcantara N, Resch J, Sayk F, Iwen KA, Franke A, Boysen TJ, Dalley JW, Lorenz K, Moran C, Rennie KL, Arner A, Kirchner H, Chatterjee K, Mittag J. Resistance to thyroid hormone induced tachycardia in RTHα syndrome. Nat Commun. 2023 Jun 7;14(1):3312. doi: 10.1038/s41467-023-38960-1. PMID:37286550 PMCID:PMC10247713
Dowsett GKC, Yeo GSH. Are GLP-1R agonists the long-sought-after panacea for obesity? Trends Mol Med. 2023 Oct;29(10):777-779. doi: 10.1016/j.molmed.2023.06.008. PMID:37460364
Duckett K, Williamson A, Kincaid JWR, Rainbow K, Corbin LJ, Martin HC, Eberhardt RY, Huang QQ, Hurles ME, He W, Brauner R, Delaney A, Dunkel L, Grinspon RP, Hall JE, Hirschhorn JN, Howard SR, Latronico AC, Jorge AAL, McElreavey K, Mericq V, Merino PM, Palmert MR, Plummer L, Rey RA, Rezende RC, Seminara SB, Salnikov K, Banerjee I, Lam BYH, Perry JRB, Timpson NJ, Clayton P, Chan YM, Ong KK, O’Rahilly S. Prevalence of deleterious variants in MC3R in patients with constitutional delay of growth and puberty. J Clin Endocrinol Metab. 2023 Jun 20:dgad373. doi: 10.1210/clinem/dgad373. PMID:37339320
Elliott RA, Rogers G, Evans ML, Neupane S, Rayman G, Lumley S, Cranston I, Narendran P, Sutton CJ, Taxiarchi VP, Burns M, Thabit H, Wilmot EG, Leelarathna L; FLASH-UK Trial Study Group. Estimating the cost-effectiveness of intermittently scanned continuous glucose monitoring in adults with type 1 diabetes in England. Diabet Med. 2023 Sep 26:e15232. doi: 10.1111/dme.15232. PMID:37750427
Fazakerley DJ, van Gerwen J, Cooke KC, Duan X, Needham EJ, Díaz-Vegas A, Madsen S, Norris DM, Shun-Shion AS, Krycer JR, Burchfield JG, Yang P, Wade MR, Brozinick JT, James DE, Humphrey SJ. Phosphoproteomics reveals rewiring of the insulin signaling network and multi-nodal defects in insulin resistance. Nat Commun. 2023 Feb 18;14(1):923. doi: 10.1038/s41467-023-36549-2. PMID:36808134 PMCID:PMC9938909
Fernandes HJR, Kent JP, Bruntraeger M, Bassett AR, Koulman A, Metzakopian E, Snowden SG. Mitochondrial and Endoplasmic Reticulum Stress Trigger Triglyceride Accumulation in Models of Parkinson’s Disease Independent of Mutations in MAPT. Metabolites. 2023 Jan 9;13(1):112.
doi: 10.3390/metabo13010112. PMID:36677037 PMCID:PMC9861589
Ferrer M, Anthony TG, Ayres JS, Biffi G, Brown JC, Caan BJ, Cespedes Feliciano EM, Coll AP, Dunne RF, Goncalves MD, Grethlein J, Heymsfield SB, Hui S, Jamal-Hanjani M, Lam JM, Lewis DY, McCandlish D, Mustian KM, O’Rahilly S, Perrimon N, White EP, Janowitz T. Cachexia: A systemic consequence of progressive, unresolved disease. Cell. 2023 Apr 27;186(9):1824-1845. doi: 10.1016/j.cell.2023.03.028. PMID:37116469
Ferrer M, Mourikis N, Davidson EE, Kleeman SO, Zaccaria M, Habel J, Rubino R, Flint TR, Connell CM, Lukey M, White EP, Coll AP, Venkitaraman AR, Janowitz T. Ketogenic diet promotes tumor ferroptosis but induces relative corticosterone deficiency that accelerates cachexia. bioRxiv. 2023 Feb 18:2023.02.17.528937. doi: 10.1101/2023.02.17.528937. PMID:36824830 PMCID:PMC9949105
Ferreira IATM, Lee CYC, Foster WS, Abdullahi A, Dratva LM, Tuong ZK, Stewart BJ, Ferdinand JR, Guillaume SM, Potts MOP, Perera M, Krishna BA, Peñalver A, Cabantous M, Kemp SA, Ceron-Gutierrez L, Ebrahimi S; CITIID-NIHR BioResource COVID-19 Collaboration; Lyons P, Smith KGC, Bradley J, Collier DA, McCoy LE, van der Klaauw A, Thaventhiran JED, Farooqi IS, Teichmann SA, MacAry PA, Doffinger R, Wills MR, Linterman MA, Clatworthy MR, Gupta RK. Atypical B cells and impaired SARS-CoV-2 neutralization following heterologous vaccination in the elderly. Cell Rep. 2023 Aug 29;42(8):112991. doi: 10.1016/j.celrep.2023.112991. PMID:37590132
Fejzo M, Rocha N, Cimino I, Lockhart SM, Petry C, Kay RG, Burling K, Barker P, George AL, Yasara N, Premawardhena A, Gong S, Cook E, Rainbow K, Withers DJ, Cortessis V, Mullin PM, MacGibbon KW, Jin E, Kam A, Campbell A, Polasek O, Tzoneva G, Gribble FM, Yeo G, Lam B, Saudek V, Hughes IA, Ong KK, Perry J, Sutton Cole A, Baumgarten M, Welsh P, Sattar N, Smith G, Charnock Jones DS, Coll AP, Meek CL, Mettananda S, Hayward C, Mancuso N, O’Rahilly S. Fetally-encoded GDF15 and maternal GDF15 sensitivity are major determinants of nausea and vomiting in human pregnancy. bioRxiv. 2023 Jun 4:2023.06.02.542661. doi: 10.1101/2023.06.02.542661. PMID:37398065 PMCID:PMC10312505
Foreman RE, Miedzybrodzka EL, Eiríksson FF, Thorsteinsdóttir M, Bannon C, Wheller R, Reimann F, Gribble FM, Kay RG. Optimized LC-MS/MS Method for the Detection of ppCCK(21-44): A Surrogate to Monitor Human Cholecystokinin Secretion. J Proteome Res. 2023 Sep 1;22(9):2950-2958. doi: 10.1021/acs.jproteome.3c00272. PMID:37591880 PMCID:PMC10476265
Funcke JB, Moepps B, Roos J, von Schnurbein J, Verstraete K, Fröhlich-Reiterer E, Kohlsdorf K, Nunziata A, Brandt S, Tsirigotaki A, Dansercoer A, Suppan E, Haris B, Debatin KM, Savvides SN, Farooqi IS, Hussain K, Gierschik P, Fischer-Posovszky P, Wabitsch M. Rare Antagonistic Leptin Variants and Severe, Early-Onset Obesity. N Engl J Med. 2023 Jun 15;388(24):2253-2261. doi: 10.1056/NEJMoa2204041. PMID:37314706
Furse S, Morgan HL, Koulman A, Watkins AJ. Characterisation of the Paternal Influence on Intergenerational Offspring Cardiac and Brain Lipid Homeostasis in Mice. Int J Mol Sci. 2023 Jan 17;24(3):1814. doi: 10.3390/ijms24031814. PMID:36768137 PMCID:PMC9916277
Ganeva I, Lim K, Boulanger J, Hoffmann PC, Muriel O, Borgeaud AC, Hagen WJH, Savage DB, Kukulski W. The architecture of Cidec-mediated interfaces between lipid droplets. Cell Rep. 2023 Feb 15;42(2):112107. doi: 10.1016/j.celrep.2023.112107. PMID:36800289 PMCID:PMC9989828
Garrud TAC, Teulings NEWD, Niu Y, Skeffington KL, Beck C, Itani N, Conlon FG, Botting KJ, Nicholas LM, Tong W, Derks JB, Ozanne SE, Giussani DA. Molecular mechanisms underlying adverse effects of dexamethasone and betamethasone in the developing cardiovascular system. FASEB J. 2023 Jun;37(6):e22887. doi: 10.1096/fj.202200676RR. PMID:37132324
George AL, Foreman RE, Sayda MH, Reimann F, Gribble FM, Kay RG. Rapid and Quantitative Enrichment of Peptides from Plasma for Mass Spectrometric Analysis. Methods Mol Biol. 2023;2628:477-488. doi: 10.1007/978-1-0716-2978-9_28. PMID:36781802
Ghatak A, Boughton CK, Allen JM, Ware J, Wilinska ME, Hartnell S, Thankamony A, Randell T, Besser REJ, Elleri D, Trevelyan N, Campbell FM, Hovorka R. Closed-Loop from Diagnosis of Type 1 Diabetes in Children and Young People. Diabetes Technol Ther. 2023 Sep;25(9):673-674. doi: 10.1089/dia.2023.0217. PMID:37384862
Gillett D, MacFarlane J, Bashari W, Crawford R, Harper I, Mendichovszky IA, Aloj L, Cheow H, Gurnell M. Molecular Imaging of Pituitary Tumors. Semin Nucl Med. 2023 Jul;53(4):530-538. doi: 10.1053/j.semnuclmed.2023.02.005. PMID:36966020
Gillett D, Marsden D, Crawford R, Ballout S, MacFarlane J, van der Meulen M, Gillett B, Bird N, Heard S, Powlson AS, Santarius T, Mannion R, Kolias A, Harper I, Mendichovszky IA, Aloj L, Cheow H, Bashari W, Koulouri O, Gurnell M. Development of a bespoke phantom to optimize molecular PET imaging of pituitary tumors. EJNMMI Phys. 2023 Jun 1;10(1):34. doi: 10.1186/s40658-023-00552-9. PMID:37261547 PMCID:PMC10234958
Goff LM, Davies K, Zelek WM, Kodosaki E, Hakim O, Lockhart S, O’Rahilly S, Morgan BP. Ethnic differences in complement system biomarkers and their association with metabolic health in men of Black African and White European ethnicity. Clin Exp Immunol. 2023 Feb 1;uxad011.doi: 10.1093/cei/uxad011. PMID:36722378
Golubic R, Hussein Ismail M, Josipovic M, Kennet J, Galderisi A, Evans ML. Sumatriptan, a serotonin 5HT1B receptor agonist, acutely reduces insulin secretion and sensitivity and glucose effectiveness in overweight humans: A double-blinded placebo-controlled cross-over trial. Diabetes Obes Metab. 2023 Jun 13. doi: 10.1111/dom.15176. PMID:37312648
Haberbosch L, Gillett D, MacFarlane J, Koulouri O, Mai K, Spranger J, Mannion R, Cheow H, Jones J, Gurnell M. Dual Role for l-[Methyl-11C]-Methionine PET in Acromegaly: Confirming Remission and Detecting Recurrence. J Nucl Med. 2023 Sep 28:jnumed.123.266446. doi: 10.2967/jnumed.123.266446. PMID:37770112
Hamblin R, Fountas A, Lithgow K, Loughrey PB, Bonanos E, Shinwari SK, Mitchell K, Shah S, Grixti L, Matheou M, Isand K, McLaren DS, Surya A, Ullah HZ, Klaucane K, Jayasuriya A, Bhatti S, Mavilakandy A, Ahsan M, Mathew S, Hussein Z, Jansz T, Wunna W, MacFarlane J, Ayuk J, Abraham P, Drake WM, Gurnell M, Brooke A, Baldeweg SE, Sam AH, Martin N, Higham C, Reddy N, Levy MJ, Ahluwalia R, Newell-Price J, Vamvakopoulos J, Krishnan A, Lansdown A, Murray RD, Pal A, Bradley K, Mamoojee Y, Purewal T, Panicker J, Freel EM, Hasan F, Kumar M, Jose B, Hunter SJ, Karavitaki N. Natural history of non-functioning pituitary microadenomas – results from the UK NFPA consortium. Eur J Endocrinol. 2023 Jun 22:lvad070. doi: 10.1093/ejendo/lvad070. PMID:37345849
Hanssen R, Auwerx C, Jõeloo M, Sadler MC; Estonian Biobank Research Team; Henning E, Keogh J, Bounds R, Smith M, Firth HV, Kutalik Z, Farooqi IS, Reymond A, Lawler K. Chromosomal deletions on 16p11.2 encompassing SH2B1 are associated with accelerated metabolic disease. Cell Rep Med. 2023 Aug 15;4(8):101155. doi: 10.1016/j.xcrm.2023.101155. PMID:37586323 PMCID:PMC10439272
Hayashi M, Kaye JA, Douglas ER, Joshi NR, Gribble FM, Reimann F, Liberles SD. Enteroendocrine cell lineages that differentially control feeding and gut motility. Elife. 2023 Feb 22;12:e78512.doi: 10.7554/eLife.78512. PMID:36810133
Huynh KA, MacFarlane J, Newman C, Gillett D, Das T, Scoffings D, Cheow HK, Moyle P, Koulouri O, Harper I, Aloj L, Mendichovszky IA, Inchiappa D, Buch HN, Chung TT, Simpson HL, Powlson AS, Challis BG, Bashari WA, Stokes VJ, Masterson L, Jani P, Fish B, Gurnell M, Casey RT. Diagnostic utility of 11 C-methionine PET/CT in primary hyperparathyroidism in a UK cohort: A single-centre experience and literature review. Clin Endocrinol (Oxf). 2023 Jun 5. doi: 10.1111/cen.14933. PMID:37272391
Jones KS, Parkington DA, Bourassa MW, Cerami C, Koulman A. Protocol and application of basal erythrocyte transketolase activity to improve assessment of thiamine status. Ann N Y Acad Sci. 2023 Jan 31. doi:10.1111/nyas.14962. PMID:36719404
Jones DL, Petry CJ, Burling K, Barker P, Turner EH, Kusinski LC, Meek CL. Pregnancy glucagon-like peptide 1 predicts insulin but not glucose concentrations. Acta Diabetol. 2023 Jul 13. doi: 10.1007/s00592-023-02142-8. PMID:37439859
Justulin LA, Zambrano E, Ong TP, Ozanne SE. Editorial: Early Life Epigenetic Programming of Health and Disease through DOHaD Perspective. Front Cell Dev Biol. 2023 Feb 10;11:1139283. doi: 10.3389/fcell.2023.1139283. PMID:36846583 PMCID:PMC9950751
Kasim HH, Olga L, Snowden S, Cropp E, Koulman A, Beardsall K. A comparative analyses of lipid ratios representing desaturase enzyme activity between preterm and term infants within the first ten weeks of life. Lipids Health Dis. 2023 Aug 23;22(1):133. doi: 10.1186/s12944-023-01862-8. PMID:37612700 PMCID:PMC10463436
Karusheva Y, Petry CJ, Yasara N, Kottahachchi D, Premawardhena A, Barker P, Burling K, Sattar N, Welsh P, Mettananda S, O’Rahilly S. Association of GDF15 levels with body mass index and endocrine status in β-thalassaemia. Clin Endocrinol (Oxf). 2023 Feb 21. doi: 10.1111/cen.14897. PMID:36806122
Kentistou KA, Kaisinger LR, Stankovic S, Vaudel M, de Oliveira EM, Messina A, Walters RG, Liu X, Busch AS, Helgason H, Thompson DJ, Farooqi IS et al. Understanding the genetic complexity of puberty timing across the allele frequency spectrum. medRxiv. 2023 Jun 20:2023.06.14.23291322. doi: 10.1101/2023.06.14.23291322. PMID:37503126 PMCID:PMC10371120
Khorisantono PA, Huang 黃飛揚 FY, Sutcliffe MPF, Fletcher PC, Farooqi IS, Grabenhorst F. A neural mechanism in the human orbitofrontal cortex for preferring high-fat foods based on oral texture. J Neurosci. 2023 Sep 21:JN-RM-1473-23. doi: 10.1523/JNEUROSCI.1473-23.2023. PMID:37845034
Krutkyte G, Roos J, Schuerch D, Czerlau C, Wilinska ME, Wuethrich PY, Herzig D, Hovorka R, Vogt AP, Gloor B, Bally L. Fully Closed-Loop Insulin Delivery in Patients Undergoing Pancreatic Surgery. Diabetes Technol Ther. 2023 Mar;25(3):206-211. doi: 10.1089/dia.2022.0400. PMID:36449375 PMCID:PMC9983122
Kusinski LC, Brown J, Hughes DJ, Meek CL. Feasibility and acceptability of continuous glucose monitoring in pregnancy for the diagnosis of gestational diabetes: A single-centre prospective mixed methods study. PLoS One. 2023 Sep 27;18(9):e0292094. doi: 10.1371/journal.pone.0292094. PMID:37756288 PMCID:PMC10529558
Kusinski LC, Richards R, Jones DL, Turner E, Hughes DJ, Dyson P, Ahern AL, Meek CL. Dietary intervention in gestational diabetes: a qualitative study of the acceptability and feasibility of a novel whole-diet intervention in healthcare professionals. Br J Nutr. 2023 Aug 10:1-10. doi: 10.1017/S0007114523001666. PMID:37642175
Kusinski LC, Tobolska P, Jones DL, Atta N, Turner EH, Lewis HB, Oude Griep LM, Gribble FM, Meek CL. Towards Novel Nutritional Strategies in Gestational Diabetes: Eating Behaviour and Obesity in Women with Gestational Diabetes Compared with Non-Pregnant Adults. Nutrients. 2023 Sep 25;15(19):4141. doi: 10.3390/nu15194141. PMID:37836424 PMCID:PMC10574012
Lakshman R, Boughton C, Hovorka R. The changing landscape of automated insulin delivery in the management of type 1 diabetes. Endocr Connect. 2023 Jun 1:EC-23-0132. doi: 10.1530/EC-23-0132. PMID:37289734
Layard Horsfall H, Lawrence A, Venkatesh A, Loh RTS, Jayapalan R, Koulouri O, Sharma R, Santarius T, Gurnell M, Dorward N, Mannion R, Marcus HJ, Kolias AG. Reported outcomes in transsphenoidal surgery for pituitary adenomas: a systematic review. Pituitary. 2023 Mar 2.
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Kusinski LC, Meek CL. Big babies, small babies: metformin exposure in pregnancy. Lancet Diabetes Endocrinol. 2023 Feb 3;S2213-8587(23)00034-7.
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Lakshman R, Daly AB, Nwokolo M, Hartnell S, Wilinska ME, Cezar A, Evans ML, Hovorka R, Boughton CK. Insulin Requirements Over Eight Weeks of Fully Closed-Loop Insulin Delivery in Adults With Type 2 Diabetes. J Diabetes Sci Technol. 2023 Mar 13:19322968231159412. doi: 10.1177/19322968231159412. PMID:36912020
Lakshman R, Daly AB, Nwokolo M, Hartnell S, Wilinska ME, Cezar A, Evans ML, Hovorka R, Boughton CK. Variability of Insulin Requirements in Adults with Type 2 Diabetes During Fully Closed-Loop Insulin Delivery. Diabetes Technol Ther. 2023 Jun;25(6):442-444. doi: 10.1089/dia.2023.0073. PMID:36971607
Lawton J, Kimbell B, Closs M, Hartnell S, Dover A, Reynolds RM, Collett C, Barnard K, Hovorka R, Rankin D, Murphy H. Listening to women: experiences of using closed-loop in type 1 diabetes pregnancy. Diabetes Technol Ther. 2023 Oct 5. doi: 10.1089/dia.2023.0323. PMID:37795883
Lawton J, Rankin D, Hartnell S, Lee T, Dover AR, Reynolds RM, Hovorka R, Murphy HR, Hart RI; AiDAPT Collaborative Group. Healthcare professionals’ views about how pregnant women can benefit from using a closed-loop system: Qualitative study. Diabet Med. 2023 May;40(5):e15072. doi: 10.1111/dme.15072. PMID:36807582
Layard Horsfall H, Loh RTS, Venkatesh A, Khan DZ, Lawrence A, Jayapalan R, Koulouri O, Borsetto D, Santarius T, Gurnell M, Dorward N, Mannion R, Marcus HJ, Kolias AG. Reported baseline variables in transsphenoidal surgery for pituitary adenoma over a 30 year period: a systematic review. Pituitary. 2023 Oct 16. doi: 10.1007/s11102-023-01357-w. PMID:37843726
Lee E, Korf H, Vidal-Puig A. An adipocentric perspective on the development and progression of non-alcoholic fatty liver disease. J Hepatol. 2023 Feb 3;S0168-8278(23)00077-6. doi: 10.1016/j.jhep.2023.01.024. PMID:36740049
Lee TTM, Collett C, Bergford S, Hartnell S, Scott EM, Lindsay RS, Hunt KF, McCance DR, Barnard-Kelly K, Rankin D, Lawton J, Reynolds RM, Flanagan E, Hammond M, Shepstone L, Wilinska ME, Sibayan J, Kollman C, Beck R, Hovorka R, Murphy HR; AiDAPT Collaborative Group. Automated Insulin Delivery in Women with Pregnancy Complicated by Type 1 Diabetes. N Engl J Med. 2023 Oct 5. doi: 10.1056/NEJMoa2303911. PMID:37796241
Lopez-Tello J, Yong HEJ, Sandovici I, Dowsett GKC, Christoforou ER, Salazar-Petres E, Boyland R, Napso T, Yeo GSH, Lam BYH, Constancia M, Sferruzzi-Perri AN. Fetal manipulation of maternal metabolism is a critical function of the imprinted Igf2 gene. Cell Metab. 2023 Jul 11;35(7):1195-1208.e6. doi: 10.1016/j.cmet.2023.06.007. PMID:37437545
Macarelli V, Leventea E, Merkle FT. Regulation of the length of neuronal primary cilia and its potential effects on signalling. Trends Cell Biol. 2023 Jun 9:S0962-8924(23)00088-0. doi: 10.1016/j.tcb.2023.05.005. PMID:37302961
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Mann JP, Duan X, Patel S, Tábara LC, Scurria F, Alvarez-Guaita A, Haider A, Luijten I, Page M, Protasoni M, Lim K, Virtue S, O’Rahilly S, Armstrong M, Prudent J, Semple RK, Savage DB. A mouse model of human mitofusin 2-related lipodystrophy exhibits adipose-specific mitochondrial stress and reduced leptin secretion. Elife. 2023 Feb 1;12:e82283.doi: 10.7554/eLife.82283. PMID:36722855
McNeilly AD, Gallagher JR, Evans ML, de Galan BE, Pedersen-Bjergaard U, Thorens B, Dinkova-Kostova AT, Huang JT, Ashford MLJ, McCrimmon RJ; Hypo-RESOLVE Consortium. Chronic hyperglycaemia increases the vulnerability of the hippocampus to oxidative damage induced during post-hypoglycaemic hyperglycaemia in a mouse model of chemically induced type 1 diabetes. Diabetologia. 2023 Jul;66(7):1340-1352. doi: 10.1007/s00125-023-05907-6. PMID:37015997 PMCID:PMC10244284
Meek CL. An unwelcome inheritance: childhood obesity after diabetes in pregnancy. Diabetologia. 2023 Nov;66(11):1961-1970. doi: 10.1007/s00125-023-05965-w. PMID:37442824 PMCID:PMC10541526
Meek CL, Simmons D. Timing of gestational diabetes diagnosis: A novel precision approach to hyperglycaemia in pregnancy? Diabet Med. 2023 Nov;40(11):e15191. doi: 10.1111/dme.15191. PMID:37528516
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Metcalfe NB, Bellman J, Bize P, Blier PU, Crespel A, Dawson NJ, Dunn RE, Halsey LG, Hood WR, Hopkins M, Killen SS, McLennan D, Nadler LE, Nati JJH, Noakes MJ, Norin T, Ozanne SE, Peaker M, Pettersen AK, Przybylska-Piech A, Rathery A, Récapet C, Rodríguez E, Salin K, Stier A, Thoral E, Westerterp KR, Westerterp-Plantenga MS, Wojciechowski MS, Monaghan P. Solving the conundrum of intra-specific variation in metabolic rate: A multidisciplinary conceptual and methodological toolkit: New technical developments are opening the door to an understanding of why metabolic rate varies among individual animals of a species: New technical developments are opening the door to an understanding of why metabolic rate varies among individual animals of a species. Bioessays. 2023 Jun;45(6):e2300026. doi: 10.1002/bies.202300026. PMID:37042115
Mocciaro G, Allison M, Jenkins B, Azzu V, Huang-Doran I, Herrera-Marcos LV, Hall Z, Murgia A, Susan D, Frontini M, Vidal-Puig A, Koulman A, Griffin JL, Vacca M. Non-alcoholic fatty liver disease is characterised by a reduced polyunsaturated fatty acid transport via free fatty acids and high-density lipoproteins (HDL). Mol Metab. 2023 Jul;73:101728. doi: 10.1016/j.molmet.2023.101728. PMID:37084865 PMCID:PMC10176260
Naulé L, Mancini A, Pereira SA, Gassaway BM, Lydeard JR, Magnotto JC, Kim HK, Liang J, Matos C, Gygi SP, Merkle FT, Carroll RS, Abreu AP, Kaiser UB. MKRN3 inhibits puberty onset via interaction with IGF2BP1 and regulation of hypothalamic plasticity. JCI Insight. 2023 Apr 24;8(8):e164178. doi: 10.1172/jci.insight.164178. PMID:37092553 PMCID:PMC10243807
Navarro-Perez J, Vidal-Puig A, Carobbio S. Recent developments in adipose tissue-secreted factors and their target organs. Curr Opin Genet Dev. 2023 Jun;80:102046. doi: 10.1016/j.gde.2023.102046. PMID:37099831
Newman C, Hartnell S, Wilinska M, Alwan H, Hovorka R. Real-World Evidence of the Cambridge Hybrid Closed-Loop App With a Novel Real-Time Continuous Glucose Monitoring System. J Diabetes Sci Technol. 2023 Jul 28:19322968231187915. doi: 10.1177/19322968231187915. PMID:37503893
Nwokolo M, Hovorka R. The Artificial Pancreas and Type 1 Diabetes. J Clin Endocrinol Metab. 2023 Jun 16;108(7):1614-1623. doi: 10.1210/clinem/dgad068. PMID:36734145
Nwokolo M, Lakshman R, Hartnell S, Alwan H, Ware J, Allen JM, Wilinska M, Evans M, Hovorka R, Boughton CK. CamAPS FX hybrid closed-loop with ultra-rapid lispro compared with standard lispro in adults with type 1 diabetes: a double-blind, randomized, crossover study. Diabetes Technol Ther. 2023 Oct 12. doi: 10.1089/dia.2023.0262. PMID:37823892
Pandey K, Bessières B, Sheng SL, Taranda J, Osten P, Sandovici I, Constancia M, Alberini CM. Neuronal activity drives IGF2 expression from pericytes to form long-term memory. Neuron. 2023 Sep 26:S0896-6273(23)00664-5. doi: 10.1016/j.neuron.2023.08.030. PMID:37788670
Parra-Vargas M, Bouret SG, Bruning JC, de Moura EG, Garland T Jr, Lisboa PC, Ozanne SE, Patti ME, Plagemann A, Speakman JR, Tena-Sempere M, Vergely C, Zeltser LM, Jiménez-Chillarón JC. The long-lasting shadow of litter size in rodents: litter size is an underreported variable that strongly determines adult physiology. Mol Metab. 2023 May;71:101707. doi: 10.1016/j.molmet.2023.101707. PMID:36933618 PMCID:PMC10074241
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Pereira C, Stalder D, Anderson GSF, Shun-Shion AS, Houghton J, Antrobus R, Chapman MA, Fazakerley DJ, Gershlick DC. The exocyst complex is an essential component of the mammalian constitutive secretory pathway. J Cell Biol. 2023 May 1;222(5):e202205137. doi: 10.1083/jcb.202205137. Epub 2023 Mar 15. PMID:36920342
Petersenn S, Fleseriu M, Casanueva FF, Giustina A, Biermasz N, Biller BMK, Bronstein M, Chanson P, Fukuoka H, Gadelha M, Greenman Y, Gurnell M, Ho KKY, Honegger J, Ioachimescu AG, Kaiser UB, Karavitaki N, Katznelson L, Lodish M, Maiter D, Marcus HJ, McCormack A, Molitch M, Muir CA, Neggers S, Pereira AM, Pivonello R, Post K, Raverot G, Salvatori R, Samson SL, Shimon I, Spencer-Segal J, Vila G, Wass J, Melmed S. Author Correction: Diagnosis and management of prolactin-secreting pituitary adenomas: a Pituitary Society international Consensus Statement. Nat Rev Endocrinol. 2023 Oct 17. doi: 10.1038/s41574-023-00916-2. PMID:37848631
Petersenn S, Fleseriu M, Casanueva FF, Giustina A, Biermasz N, Biller BMK, Bronstein M, Chanson P, Fukuoka H, Gadelha M, Greenman Y, Gurnell M, Ho KKY, Honegger J, Ioachimescu AG, Kaiser UB, Karavitaki N, Katznelson L, Lodish M, Maiter D, Marcus HJ, McCormack A, Molitch M, Muir CA, Neggers S, Pereira AM, Pivonello R, Post K, Raverot G, Salvatori R, Samson SL, Shimon I, Spencer-Segal J, Vila G, Wass J, Melmed S. Diagnosis and management of prolactin-secreting pituitary adenomas: a Pituitary Society international Consensus Statement. Nat Rev Endocrinol. 2023 Sep 5. doi: 10.1038/s41574-023-00886-5. PMID:37670148
Ramos-Pittol JM, Fernandes-Freitas I, Milona A, Manchishi SM, Rainbow K, Lam BYH, Tadross JA, Beucher A, Colledge WH, Cebola I, Murphy KG, Miguel-Aliaga I, Yeo GSH, Dhillo WS, Owen BM. Dax1 modulates ERα-dependent hypothalamic estrogen sensing in female mice. Nat Commun. 2023 May 29;14(1):3076. doi: 10.1038/s41467-023-38618-y. PMID:37248237 PMCID:PMC10227040
Rankin D, Hart RI, Kimbell B, Barnard-Kelly K, Brackenridge A, Byrne C, Collett C, Dover AR, Hartnell S, Hunt KF, Lee TTM, Lindsay RS, McCance DR, McKelvey A, Rayman G, Reynolds RM, Scott EM, White SL, Hovorka R, Murphy HR, Lawton J. Rollout of Closed-Loop Technology to Pregnant Women with Type 1 Diabetes: Healthcare Professionals’ Views About Potential Challenges and Solutions. Diabetes Technol Ther. 2023 Apr;25(4):260-269. doi: 10.1089/dia.2022.0479. PMID:36662589 PMCID:PMC10066772
Reimann F. Dorothy Hodgkin lecture 2023: The enteroendocrine system-Sensors in your guts. Diabet Med. 2023 Aug 28:e15212. doi: 10.1111/dme.15212. PMID:37638546
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Rubino F, Batterham RL, Koch M, Mingrone G, le Roux CW, Farooqi IS, Farpour-Lambert N, Gregg EW, Cummings DE. Lancet Diabetes & Endocrinology Commission on the Definition and Diagnosis of Clinical Obesity. Lancet Diabetes Endocrinol. 2023 Mar 3:S2213-8587(23)00058-X. doi: 10.1016/S2213-8587(23)00058-X. PMID:36878238
Saeed S, Khanam R, Janjua QM, Manzoor J, Ning L, Hanook S, Canouil M, Ali M, Ayesha H, Khan WI, Farooqi IS, Yeo GSH, O’Rahilly S, Bonnefond A, Butt TA, Arslan M, Froguel P. High morbidity and mortality in children with untreated congenital deficiency of leptin or its receptor. Cell Rep Med. 2023 Sep 19;4(9):101187. doi: 10.1016/j.xcrm.2023.101187. PMID:37659411 PMCID:PMC10518629
Saeed S, Ning L, Badreddine A, Mirza MU, Boissel M, Khanam R, Manzoor J, Janjua QM, Khan WI, Toussaint B, Vaillant E, Amanzougarene S, Derhourhi M, Trant JF, Siegert AM, Lam BYH, Yeo GSH, Chabraoui L, Touzani A, Kulkarni A, Farooqi IS, Bonnefond A, Arslan M, Froguel P. Biallelic mutations in P4HTM cause syndromic obesity. Diabetes. 2023 Apr 21:db221017. doi: 10.2337/db22-1017. PMID:37083980
Santos A, Delgado TC, Marques V, Moncayo CR, Alonso C, Vidal-Puig A, Hall Z, Martínez-Chantar ML, Rodrigues CMP. Spatial metabolomics and its application in the liver. Hepatology. 2023 Feb 27. doi: 10.1097/HEP.0000000000000341. PMID:36811413
Savage DB. Perilipin 1 Antibodies in Patients With Acquired Generalized Lipodystrophy. Diabetes. 2023 Jan 1;72(1):16-18. doi: 10.2337/dbi22-0022. PMID:36538601
Schneider-Utaka AK, Hanes S, Boughton CK, Hartnell S, Thabit H, Mubita WM, Draxlbauer K, Poettler T, Hayes J, Wilinska ME, Mader JK, Narendran P, Leelarathna L, Evans ML, Hovorka R, Hood KK. Patient-reported outcomes for older adults on CamAPS FX closed loop system. Diabet Med. 2023 May 12:e15126. doi: 10.1111/dme.15126. PMID:37171467
Shekari S, Stankovic S, Gardner EJ, Hawkes G, Kentistou KA, Beaumont RN, Mörseburg A, Wood AR, Prague JK, Mishra GD, Day FR, Baptista J, Wright CF, Weedon MN, Hoffmann ER, Ruth KS, Ong KK, Perry JRB, Murray A. Penetrance of pathogenic genetic variants associated with premature ovarian insufficiency. Nat Med. 2023 Jun 22. doi: 10.1038/s41591-023-02405-5. PMID:37349538
Soria-Gondek A, Fernández-García P, González L, Reyes-Farias M, Murillo M, Valls A, Real N, Pellitero S, Tarascó J, Jenkins B, Galán M, Villarroya F, Koulman A, Corrales P, Vidal-Puig A, Cereijo R, Sánchez-Infantes D. Lipidome Profiling in Childhood Obesity Compared to Adults: A Pilot Study. Nutrients. 2023 Jul 27;15(15):3341. doi: 10.3390/nu15153341. PMID:37571279 PMCID:PMC10421258
Talbot F, Feetham CH, Mokrosiński J, Lawler K, Keogh JM, Henning E, Mendes de Oliveira E, Ayinampudi V, Saeed S, Bonnefond A, Arslan M, Yeo GSH, Froguel P, Bechtold DA, Adamson A, Humphreys N, Barroso I, Luckman SM, Farooqi IS. A rare human variant that disrupts GPR10 signalling causes weight gain in mice. Nat Commun. 2023 Mar 15;14(1):1450. doi: 10.1038/s41467-023-36966-3. PMID:36922513 PMCID:PMC10017677
Tarry-Adkins JL, Robinson IG, Pantaleão LC, Armstrong JL, Thackray BD, Holzner LMW, Knapton AE, Virtue S, Jenkins B, Koulman A, Murray AJ, Ozanne SE, Aiken CE. The metabolic response of human trophoblasts derived from term placentas to metformin. Diabetologia. 2023 Sep 5. doi: 10.1007/s00125-023-05996-3. PMID:37670017
Taylor R, Barnes AC, Hollingsworth KG, Irvine KM, Solovyova AS, Clark L, Kelly T, Martin-Ruiz C, Romeres D, Koulman A, Meek CM, Jenkins B, Cobelli C, Holman RR. Aetiology of Type 2 diabetes in people with a ‘normal’ body mass index: testing the personal fat threshold hypothesis. Clin Sci (Lond). 2023 Aug 31;137(16):1333-1346. doi: 10.1042/CS20230586. PMID:37593846 PMCID:PMC10472166
Thabit H, Mubita W, Rubio J, Karuppan M, Schofield J, Willinska ME, Hovorka R, Leelarathna L. Comparison of faster-acting aspart with insulin aspart under conditions mimicking underestimation or missed meal boluses in type 1 diabetes using closed-loop insulin delivery. Diabetes Obes Metab. 2023 Apr;25(4):1121-1124. doi: 10.1111/dom.14942. PMID:36514847
Tsang A, Blouet C. A pipeline for identification and validation of brain targets for weight loss. Nat Rev Endocrinol. 2023 Jan 25. doi: 10.1038/s41574-023-00803-w. PMID:36697769 PMCID:PMC9873557
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van der Klaauw AA, Horner EC, Pereyra-Gerber P, Agrawal U, Foster WS, Spencer S, Vergese B, Smith M, Henning E, Ramsay ID, Smith JA, Guillaume SM, Sharpe HJ, Hay IM, Thompson S, Innocentin S, Booth LH, Robertson C, McCowan C, Kerr S, Mulroney TE, O’Reilly MJ, Gurugama TP, Gurugama LP, Rust MA, Ferreira A, Ebrahimi S, Ceron-Gutierrez L, Scotucci J, Kronsteiner B, Dunachie SJ, Klenerman P; PITCH Consortium; Park AJ, Rubino F, Lamikanra AA, Stark H, Kingston N, Estcourt L, Harvala H, Roberts DJ, Doffinger R, Linterman MA, Matheson NJ, Sheikh A, Farooqi IS, Thaventhiran JED. Accelerated waning of the humoral response to COVID-19 vaccines in obesity. Nat Med. 2023 May;29(5):1146-1154. doi: 10.1038/s41591-023-02343-2. PMID:37169862 PMCID:PMC10202802
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Wagner S, Brierley DI, Leeson-Payne A, Jiang W, Chianese R, Lam BYH, Dowsett GKC, Cristiano C, Lyons D, Reimann F, Gribble FM, Martinez de Morentin PB, Yeo GSH, Trapp S, Heisler LK. Obesity medication lorcaserin activates brainstem GLP-1 neurons to reduce food intake and augments GLP-1 receptor agonist induced appetite suppression. Mol Metab. 2023 Feb;68:101665. doi: 10.1016/j.molmet.2022.101665. PMID:36592795 PMCID:PMC9841057
Ware J, Allen JM, Boughton CK, Cezar A, Hartnell S, Wilinska ME, Thankamony A, Deakin M, Leyland H, Phelan K, Thornborough K, Hovorka R. Hybrid Closed-Loop with Faster Insulin Aspart Compared with Standard Insulin Aspart in Very Young Children with Type 1 Diabetes: A Double-Blind, Multicenter, Randomized, Crossover Study. Diabetes Technol Ther. 2023 Jun;25(6):431-436. doi: 10.1089/dia.2023.0042. PMID:36880866
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White SL, Koulman A, Ozanne SE, Furse S, Poston L, Meek CL. Towards precision medicine in gestational diabetes: pathophysiology and glycemic patterns in pregnant women with obesity. J Clin Endocrinol Metab. 2023 Mar 23:dgad168. doi: 10.1210/clinem/dgad168. PMID:36950879
Wilcox N, Dumont M, González-Neira A, Carvalho S, Joly Beauparlant C, Crotti M, Luccarini C, Soucy P, Dubois S, Nuñez-Torres R, Pita G, Gardner EJ, Dennis J, Alonso MR, Álvarez N, Baynes C, Collin-Deschesnes AC, Desjardins S, Becher H, Behrens S, Bolla MK, Castelao JE, Chang-Claude J, Cornelissen S, Dörk T, Engel C, Gago-Dominguez M, Guénel P, Hadjisavvas A, Hahnen E, Hartman M, Herráez B; SGBCC Investigators; Jung A, Keeman R, Kiechle M, Li J, Loizidou MA, Lush M, Michailidou K, Panayiotidis MI, Sim X, Teo SH, Tyrer JP, van der Kolk LE, Wahlström C, Wang Q, Perry JRB, Benitez J, Schmidt MK, Schmutzler RK, Pharoah PDP, Droit A, Dunning AM, Kvist A, Devilee P, Easton DF, Simard J. Author Correction: Exome sequencing identifies breast cancer susceptibility genes and defines the contribution of coding variants to breast cancer risk. Nat Genet. 2023 Sep 26. doi: 10.1038/s41588-023-01549-x. PMID:37752376
Wilcox N, Dumont M, González-Neira A, Carvalho S, Joly Beauparlant C, Crotti M, Luccarini C, Soucy P, Dubois S, Nuñez-Torres R, Pita G, Gardner EJ, Dennis J, Alonso MR, Álvarez N, Baynes C, Collin-Deschesnes AC, Desjardins S, Becher H, Behrens S, Bolla MK, Castelao JE, Chang-Claude J, Cornelissen S, Dörk T, Engel C, Gago-Dominguez M, Guénel P, Hadjisavvas A, Hahnen E, Hartman M, Herráez B; SGBCC Investigators; Jung A, Keeman R, Kiechle M, Li J, Loizidou MA, Lush M, Michailidou K, Panayiotidis MI, Sim X, Teo SH, Tyrer JP, van der Kolk LE, Wahlström C, Wang Q, Perry JRB, Benitez J, Schmidt MK, Schmutzler RK, Pharoah PDP, Droit A, Dunning AM, Kvist A, Devilee P, Easton DF, Simard J. Exome sequencing identifies breast cancer susceptibility genes and defines the contribution of coding variants to breast cancer risk. Nat Genet. 2023 Sep;55(9):1435-1439. doi: 10.1038/s41588-023-01466-z. PMID:37592023
Williamson A, Norris DM, Yin X, Broadaway KA, Moxley AH, Vadlamudi S, Wilson EP, Jackson AU, Ahuja V, Andersen MK, Arzumanyan Z, Bonnycastle LL, Bornstein SR, Bretschneider MP, Buchanan TA, Chang YC, Chuang LM, Chung RH, Clausen TD, Damm P, Delgado GE, de Mello VD, Dupuis J, Dwivedi OP, Erdos MR, Silva LF, Frayling TM, Gieger C, Goodarzi MO, Guo X, Gustafsson S, Hakaste L, Hammar U, Hatem G, Herrmann S, Højlund K, Horn K, Hsueh WA, Hung YJ, Hwu CM, Jonsson A, Kårhus LL, Kleber ME, Kovacs P, Lakka TA, Lauzon M, Lee IT, Lindgren CM, Lindström J, Linneberg A, Liu CT, Luan J, Aly DM, Mathiesen E, Moissl AP, Morris AP, Narisu N, Perakakis N, Peters A, Prasad RB, Rodionov RN, Roll K, Rundsten CF et al. Genome-wide association study and functional characterization identifies candidate genes for insulin-stimulated glucose uptake. Nat Genet. 2023 Jun;55(6):973-983. doi: 10.1038/s41588-023-01408-9. PMID:37291194
Wu Q, Wu J, Karim K, Chen X, Wang T, Iwama S, Carobbio S, Keen P, Vidal-Puig A, Kotter MR, Bassett A. Massively parallel characterization of CRISPR activator efficacy in human induced pluripotent stem cells and neurons. Mol Cell. 2023 Mar 3:S1097-2765(23)00114-4. doi: 10.1016/j.molcel.2023.02.011. PMID:36917981
Wu X, Azizan EAB, Goodchild E, Garg S, Hagiyama M, Cabrera CP, Fernandes-Rosa FL, Boulkroun S, Kuan JL, Tiang Z, David A, Murakami M, Mein CA, Wozniak E, Zhao W, Marker A, Buss F, Saleeb RS, Salsbury J, Tezuka Y, Satoh F, Oki K, Udager AM, Cohen DL, Wachtel H, King PJ, Drake WM, Gurnell M, Ceral J, Ryska A, Mustangin M, Wong YP, Tan GC, Solar M, Reincke M, Rainey WE, Foo RS, Takaoka Y, Murray SA, Zennaro MC, Beuschlein F, Ito A, Brown MJ. Somatic mutations of CADM1 in aldosterone-producing adenomas and gap junction-dependent regulation of aldosterone production. Nat Genet. 2023 Jun;55(6):1009-1021. doi: 10.1038/s41588-023-01403-0. PMID:37291193 PMCID:PMC10260400
Xu J, Cui L, Wang J, Zheng S, Zhang H, Ke S, Cao X, Shi Y, Li J, Zen K, Vidal-Puig A, Zhang CY, Li L, Jiang X. Cold-activated brown fat-derived extracellular vesicle-miR-378a-3p stimulates hepatic gluconeogenesis in male mice. Nat Commun. 2023 Sep 6;14(1):5480. doi: 10.1038/s41467-023-41160-6. PMID:37673898 PMCID:PMC10482845

2022

Andrews PW, Barbaric I, Benvenisty N, Draper JS, Ludwig T, Merkle FT, Sato Y, Spits C, Stacey GN, Wang H, Pera MF. The consequences of recurrent genetic and epigenetic variants in human pluripotent stem cells. Cell Stem Cell. 2022 Dec 1;29(12):1624-1636. doi: 10.1016/j.stem.2022.11.006. PMID:36459966
Annamalai AK, Gurnell M. Black urine-alkaptonuria. QJM. 2022 Jun 7;115(6):397-398. doi: 10.1093/qjmed/hcac098. PMID:35394539
Annamalai AK, Prajna VN, Chowdhury G, Santhi R, Kannan M, Vedantham S, Gurnell M. Wilson Disease: Never Too Late. Am J Med. 2022 May 14:S0002-9343(22)00362-X. doi: 10.1016/j.amjmed.2022.04.025. PMID:35580721
Arima H, Bichet DG, Cheetham T, Christ-Crain M, Drummond J, Gurnell M, Levy M, McCormack A, Newell-Price J, Verbalis JG, Wass J, Cooper D. Changing the name of diabetes insipidus. Pituitary. 2022 Dec;25(6):777-779. doi: 10.1007/s11102-022-01276-2. PMID:36334185
Arima H, Cheetham T, Christ-Crain M, Cooper DL, Drummond JB, Gurnell M, Levy M, McCormack A, Newell-Price JD, Verbalis JG, Wass J. Changing the name of diabetes insipidus: a position statement of the working group to consider renaming diabetes insipidus. Arch Endocrinol Metab. 2022 Oct 11:2359-3997000000528. doi: 10.20945/2359-3997000000528. PMID:36219203
Arima H, Cheetham T, Christ-Crain M, Cooper D, Drummond J, Gurnell M, Levy M, McCormack A, Newell-Price J, Verbalis JG, Wass J; Working Group for Renaming Diabetes Insipidus. Changing the Name of Diabetes Insipidus: A Position Statement of the Working Group for Renaming Diabetes Insipidus. J Clin Endocrinol Metab. 2022 Nov 9:dgac547. doi: 10.1210/clinem/dgac547. PMID:36355385
Arima H, Cheetham T, Christ-Crain M, Cooper DL, Drummond JB, Gurnell M, Levy M, McCormack A, Newell-Price JD, Verbalis JG, Wass J. Changing the Name of Diabetes Insipidus: A Position Statement of the Working Group to Consider Renaming Diabetes Insipidus. Horm Res Paediatr. 2022 Sep 30:1-3. doi: 10.1159/000527139. PMID:36183693
Arima H, Cheetham T, Christ-Crain M, Cooper D, Drummond J, Gurnell M, Levy M, McCormack A, Newell-Price J, Verbalis JG, Wass J. Changing the name of diabetes insipidus: a position statement of the working group to consider renaming diabetes insipidus. Clin Endocrinol (Oxf). 2022 Aug 28. doi: 10.1111/cen.14819. PMID:36030512
Aye ILMH, Gong S, Avellino G, Barbagallo R, Gaccioli F, Jenkins BJ, Koulman A, Murray AJ, Stephen Charnock-Jones D, Smith GCS. Placental sex-dependent spermine synthesis regulates trophoblast gene expression through acetyl-coA metabolism and histone acetylation. Commun Biol. 2022 Jun 15;5(1):586. doi: 10.1038/s42003-022-03530-6. PMID:35705689 PMCID:PMC9200719
Bakker LEH, Verstegen MJT, Ghariq E, Verbist BM, Schutte PJ, Bashari WA, Kruit MC, Pereira AM, Gurnell M, Biermasz NR, van Furth WR, Bouda LMPA. Implementation of functional imaging using 11 C-methionine PET-CT co-registered with MRI for advanced surgical planning and decision making in prolactinoma surgery. Pituitary. 2022 May 26. doi: 10.1007/s11102-022-01230-2. PMID:35616762
Bashari WA, Gillett D, MacFarlane J, Powlson AS, Kolias AG, Mannion R, Scoffings DJ, Mendichovszky IA, Jones J, Cheow HK, Koulouri O, Gurnell M. Modern imaging in Cushing’s disease. Pituitary. 2022 Jun 6. doi: 10.1007/s11102-022-01236-w. PMID:35666391
Bashari WA, van der Meulen M, MacFarlane J, Gillett D, Senanayake R, Serban L, Powlson AS, Brooke AM, Scoffings DJ, Jones J, O’Donovan DG, Tysome J, Santarius T, Donnelly N, Boros I, Aigbirhio F, Jefferies S, Cheow HK, Mendichovszky IA, Kolias AG, Mannion R, Koulouri O, Gurnell M. 11 C-methionine PET aids localization of microprolactinomas in patients with intolerance or resistance to dopamine agonist therapy. Pituitary. 2022 May 24. doi: 10.1007/s11102-022-01229-9. PMID:35608811
Bethlehem RAI, Seidlitz J, White SR, Vogel JW, Anderson KM, Adamson C, Adler S, Alexopoulos GS, Anagnostou E, Areces-Gonzalez A, Astle DE, Auyeung B, Ayub M, Bae J, Ball G, Baron-Cohen S, Beare R, Bedford SA, Benegal V, Beyer F, Blangero J, Blesa Cábez M, Boardman JP, Borzage M, Bosch-Bayard JF, Bourke N, Calhoun VD, Chakravarty MM, Chen C, Chertavian C, Chetelat G, Chong YS, Cole JH, Corvin A, Costantino M, Courchesne E, Crivello F, Cropley VL, Crosbie J, Crossley N, Delarue M, Delorme R, Desrivieres S, Devenyi GA, Di Biase MA, Dolan R, Donald KA, Donohoe G, Dunlop K, Edwards AD, Elison JT, Ellis CT, Elman JA, Eyler L, Fair DA, Feczko E, Fletcher PC, Fonagy P, Franz CE, Galan-Garcia L, Gholipour A, Giedd J, Gilmore JH, Glahn DC, Goodyer IM, Grant PE, Groenewold NA, Gunning FM, Gur RE, Gur RC, Hammill CF, Hansson O, Hedden T, Heinz A, Henson RN, Heuer K, Hoare J, Holla B, Holmes AJ, Holt R, Huang H, Im K, Ipser J, Jack CR Jr, Jackowski AP, Jia T, Johnson KA, Jones PB, Jones DT, Kahn RS, Karlsson H, Karlsson L, Kawashima R, Kelley EA, Kern S, Kim KW, Kitzbichler MG, Kremen WS, Lalonde F, Landeau B, Lee S, Lerch J, Lewis JD, Li J, Liao W, Liston C, Lombardo MV, Lv J, Lynch C, Mallard TT, Marcelis M, Markello RD, Mathias SR, Mazoyer B, McGuire P, Meaney MJ, Mechelli A, Medic N, Misic B, Morgan SE, Mothersill D, Nigg J, Ong MQW, Ortinau C, Ossenkoppele R, Ouyang M, Palaniyappan L, Paly L, Pan PM, Pantelis C, Park MM, Paus T, Pausova Z, Paz-Linares D, Pichet Binette A, Pierce K, Qian X, Qiu J, Qiu A, Raznahan A, Rittman T, Rodrigue A, Rollins CK, Romero-Garcia R, Ronan L, Rosenberg MD, Rowitch DH, Salum GA, Satterthwaite TD, Schaare HL, Schachar RJ, Schultz AP, Schumann G, Schöll M, Sharp D, Shinohara RT, Skoog I, Smyser CD, Sperling RA, Stein DJ, Stolicyn A, Suckling J, Sullivan G, Taki Y, Thyreau B, Toro R, Traut N, Tsvetanov KA, Turk-Browne NB, Tuulari JJ, Tzourio C, Vachon-Presseau É, Valdes-Sosa MJ, Valdes-Sosa PA, Valk SL, van Amelsvoort T, Vandekar SN, Vasung L, Victoria LW, Villeneuve S, Villringer A, Vértes PE, Wagstyl K, Wang YS, Warfield SK, Warrier V, Westman E, Westwater ML, Whalley HC, Witte AV, Yang N, Yeo B, Yun H, Zalesky A, Zar HJ, Zettergren A, Zhou JH, Ziauddeen H, Zugman A, Zuo XN; 3R-BRAIN; AIBL; Alzheimer’s Disease Neuroimaging Initiative; Alzheimer’s Disease Repository Without Borders Investigators; CALM Team; Cam-CAN; CCNP; COBRE; cVEDA; ENIGMA Developmental Brain Age Working Group; Developing Human Connectome Project; FinnBrain; Harvard Aging Brain Study; IMAGEN; KNE96; Mayo Clinic Study of Aging; NSPN; POND; PREVENT-AD Research Group; VETSA, Bullmore ET, Alexander-Bloch AF. Publisher Correction: Brain charts for the human lifespan. Nature. 2022 Oct;610(7931):E6. doi: 10.1038/s41586-022-05300-0. PMID:36151472 PMCID:PMC9556297
Boughton CK, Allen JM, Ware J, Wilinska ME, Hartnell S, Thankamony A, Randell T, Ghatak A, Besser REJ, Elleri D, Trevelyan N, Campbell FM, Sibayan J, Calhoun P, Bailey R, Dunseath G, Hovorka R; CLOuD Consortium. Closed-Loop Therapy and Preservation of C-Peptide Secretion in Type 1 Diabetes. N Engl J Med. 2022 Sep 8;387(10):882-893. doi: 10.1056/NEJMoa2203496. PMID:36069870
Boughton CK, Hartnell S, Thabit H, Mubita WM, Draxlbauer K, Poettler T, Wilinska ME, Hood KK, Mader JK, Narendran P, Leelarathna L, Evans ML, Hovorka R. Hybrid closed-loop glucose control compared with sensor augmented pump therapy in older adults with type 1 diabetes: an open-label multicentre, multinational, randomised, crossover study. Lancet Healthy Longev. 2022 Mar;3(3):e135-e142. doi: 10.1016/S2666-7568(22)00005-8. PMID:35359882 PMCID:PMC8967297
Braithwaite VS, Sharp SJ, Koulman A, Wareham NJ, Rennie KL. An investigation of factors affecting changes in health behaviours during the COVID-19 pandemic in a UK population-based cohort study. Public Health. 2022 Sep 6;212:46-54. doi: 10.1016/j.puhe.2022.08.005. PMID:36209533 PMCID:PMC9444493
Brown CA, Badger K, Reid MD, Westacott R, Gurnell M, Reed MWR, Chamberlain G, Hatfield E, Sharif A, Sam AH. The influence of candidates’ physical attributes on patient ratings in simulated assessments of clinical practice. Med Teach. 2022 Jul 12:1-6. doi: 10.1080/0142159X.2022.2093177. PMID:35820076
Cacciottolo TM, Henning E, Keogh JM, Bel Lassen P, Lawler K, Bounds R, Ahmed R, Perdikari A, Mendes de Oliveira E, Smith M, Godfrey EM, Johnson E, Hodson L, Clément K, van der Klaauw AA, Farooqi IS. Obesity due to Steroid Receptor Coactivator-1 deficiency is associated with endocrine and metabolic abnormalities. J Clin Endocrinol Metab. 2022 Feb 8:dgac067. doi: 10.1210/clinem/dgac067. PMID: 35137184
Calderon RM, Smith CA, Miedzybrodzka EL, Silvaroli JA, Golczak M, Gribble FM, Reimann F, Blaner WS. Intestinal Enteroendocrine Cell Signaling: Retinol-binding Protein 2 and Retinoid Actions. Endocrinology. 2022 Jul 1;163(7):bqac064. doi: 10.1210/endocr/bqac064. PMID:35552670 PMCID:PMC9162388
Calejman CM, Doxsey WG, Fazakerley DJ, Guertin DA. Integrating adipocyte insulin signaling and metabolism in the multi-omics era. Trends Biochem Sci. 2022 Mar 15:S0968-0004(22)00050-0. doi: 10.1016/j.tibs.2022.02.009. PMID:35304047
Campbell JE, Beaudry JL, Svendsen B, Baggio LL, Gordon AN, Ussher JR, Wong CK, Gribble FM, D’Alessio DA, Reimann F, Drucker DJ. The GIPR is Predominantly Localized to Non-Adipocyte Cell Types Within White Adipose Tissue. Diabetes. 2022 Feb 22:db211166. doi: 10.2337/db21-1166.PMID: 35192688
Daniel-Watanabe L, Fletcher PC. Are Fear and Anxiety Truly Distinct? Biol Psychiatry Glob Open Sci. 2021 Oct 6;2(4):341-349. doi: 10.1016/j.bpsgos.2021.09.006. PMID:36324663 PMCID:PMC9616241
Dennison RA, Griffin SJ, Usher-Smith JA, Fox RA, Aiken CE, Meek CL. “Post-GDM support would be really good for mothers”: A qualitative interview study exploring how to support a healthy diet and physical activity after gestational diabetes. PLoS One. 2022 Jan 21;17(1):eo262852. doi: 10.1371/journal.pone.0262852. PMID:35061856 PMCID:PMC8782419
Diaz-Vegas A, Norris DM, Jall-Rogg S, Cooke KC, Conway OJ, Shun-Shion AS, Duan X, Potter M, van Gerwen J, Baird HJ, Humphrey SJ, James DE, Fazakerley DJ, Burchfield JG. A high-content endogenous GLUT4 trafficking assay reveals new aspects of adipocyte biology. Life Sci Alliance. 2022 Oct 25;6(1):e202201585. doi: 10.26508/lsa.202201585. PMID:36283703 PMCID:PMC9595207
Duan X, Norris DM, Humphrey SJ, Yang P, Cooke KC, Bultitude WP, Parker BL, Conway OJ, Burchfield JG, Krycer JR, Brodsky FM, James DE, Fazakerley DJ. Trafficking regulator of GLUT4-1 (TRARG1) is a GSK3 substrate. Biochem J. 2022 Jun 17;479(11):1237-1256. doi: 10.1042/BCJ20220153. PMID:35594055
Edwards CA, Van Loo-Bouwman CA, Van Diepen JA, Schoemaker MH, Ozanne SE, Venema K, Stanton C, Marinello V, Rueda R, Flourakis M, Gil A, Van der Beek EM. A systematic review of breast milk microbiota composition and the evidence for transfer to and colonisation of the infant gut. Benef Microbes. 2022 Nov 16;13(5):365-381. doi: 10.3920/BM2021.0098. PMID:36377578
Farooqi IS. Monogenic Obesity Syndromes Provide Insights Into the Hypothalamic Regulation of Appetite and Associated Behaviors. Biol Psychiatry. 2022 May 15;91(10):856-859. doi: 10.1016/j.biopsych.2022.01.018. PMID:35369984
Fattah M, Boughton CK, Ware J, Allen JM, Hartnell S, Willinska ME, Thankamony A, de Beaufort C, Campbell FM, Fröhlich-Reiterer E, Hofer SE, Kapellen TM, Rami-Merhar B, Ghatak A, Randell TL, Besser REJ, Elleri D, Trevelyan N, Denvir Md L, Davis N, Bally L, Thabit H, Leelarathna L, Evans ML, Mader JK, Hovorka R. Evaluating the Impact of Applying Personal Glucose Targets in a Closed-Loop System for People With Type 1 Diabetes. J Diabetes Sci Technol. 2022 Dec 20;19322968221145184.doi: 10.1177/19322968221145184. PMID:36540007
Fazakerley DJ, Koumanov F, Holman GD. GLUT4 On the move. Biochem J. 2022 Feb 11;479(3):445-462. doi: 10.1042/BCJ20210073. PMID:35147164 PMCID:PMC8883492
Fletcher PC, Teufel CR. The Changing Weight of Expectation: How Shifting Priors Underpin Variability in Hallucination Frequency. Biol Psychiatry. 2022 Nov 15;92(10):752-753. doi: 10.1016/j.biopsych.2022.08.027. PMID:36265965
Foreman RE, Meek CL, Roberts GP, George AL, Reimann F, Gribble FM, Kay RG. LC-MS/MS based detection of circulating proinsulin derived peptides in patients with altered pancreatic beta cell function. J Chromatogr B Analyt Technol Biomed Life Sci. 2022 Oct 5;1211:123482. doi: 10.1016/j.jchromb.2022.123482. PMID: 36242807
Furigo IC, Dearden L. Mechanisms mediating the impact of maternal obesity on offspring hypothalamic development and later function. Front Endocrinol (Lausanne). 2022 Dec 22;13:1078955. doi: 10.3389/fendo.2022.1078955. PMID:36619540 PMCID:PMC9813846
Furse S, Fernandez-Twinn DS, Beeson JH, Chiarugi D, Ozanne SE, Koulman A. A mouse model of gestational diabetes shows dysregulated lipid metabolism post-weaning, after return to euglycaemia. Nutr Diabetes. 2022 Feb 15;12(1):8. doi: 10.1038/s41387-022-00185-4. PMID: 35169132 PMCID: PMC8847647
Furse S, Koulman A, Ozanne SE, Poston L, White SL, Meek CL. Altered Lipid Metabolism in Obese Women With Gestational Diabetes and Associations With Offspring Adiposity. J Clin Endocrinol Metab. 2022 Jun 16;107(7):e2825-e2832. doi: 10.1210/clinem/dgac206. PMID:35359001
Furse S, Kusinski LC, Ray A, Glenn-Sansum C, Williams HEL, Koulman A, Meek CL. Relative Abundance of Lipid Metabolites in Spermatozoa across Three Compartments. Int J Mol Sci. 2022 Oct 1;23(19):11655. doi: 10.3390/ijms231911655. PMID:36232961 PMCID:PMC9569887
Furse S, Virtue S, Snowden SG, Vidal-Puig A, Stevenson PC, Chiarugi D, Koulman A. Dietary PUFAs drive diverse system-level changes in lipid metabolism. Mol Metab. 2022 May;59:101457. doi: 10.1016/j.molmet.2022.101457. PMID:35150907 PMCID:PMC8894240
Furse S, Watkins AJ, Williams HEL, Snowden SG, Chiarugi D, Koulman A. Paternal nutritional programming of lipid metabolism is propagated through sperm and seminal plasma. Metabolomics. 2022 Feb 10;18(2):13. doi: 10.1007/s11306-022-01869-9. PMID:35141784 PMCID: PMC8828597
Gardner EJ, Kentistou KA, Stankovic S, Lockhart S, Wheeler E, Day FR, Kerrison ND, Wareham NJ, Langenberg C, O’Rahilly S, Ong KK, Perry JRB. Damaging missense variants in IGF1R implicate a role for IGF-1 resistance in the etiology of type 2 diabetes. Cell Genom. 2022 Dec 14;2(12):None.
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Giakoumaki I, Pollock N, Aljuaid T, Sannicandro AJ, Alameddine M, Owen E, Myrtziou I, Ozanne SE, Kanakis I, Goljanek-Whysall K, Vasilaki A. Postnatal Protein Intake as a Determinant of Skeletal Muscle Structure and Function in Mice-A Pilot Study. Int J Mol Sci. 2022 Aug 8;23(15):8815. doi: 10.3390/ijms23158815. PMID:35955948 PMCID:PMC9369224
Gillett D, Senanayake R, MacFarlane J, van der Meulen M, Koulouri O, Powlson AS, Crawford R, Gillett B, Bird N, Heard S, Kolias A, Mannion R, Aloj L, Mendichovszky IA, Cheow H, Bashari WA, Gurnell M. Localization of TSH-secreting pituitary adenoma using 11C-methionine image subtraction. EJNMMI Res. 2022 May 7;12(1):26. doi: 10.1186/s13550-022-00899-7. PMID:35524902 PMCID:PMC9079199
Glasgow C, Lau EYC, Aloj L, Harper I, Cheow H, Das T, Berman L, Powlson AS, Bashari W, Challis BG, Marker A, Moyle P, Mohamed I, Schoenmakers N, Broomfield J, Oddy S, Moran C, Gurnell M, Jani P, Masterson L, Fish B, Casey RT. An approach to a patient with primary hyperparathyroidism and a suspected ectopic parathyroid adenoma. J Clin Endocrinol Metab. 2022 Feb 12;dgac024. doi:10.1210/clinem/dgac024.PMID: 35150267
Gregory AM, Rutter MK, Ware J, Madrid-Valero JJ, Hovorka R, Buysse DJ. Type 1 diabetes as a prototypical condition challenging what we know about sleep. Sleep. 2022 Sep 21:zsac194. doi: 10.1093/sleep/zsac194. PMID:36130325
Grigoriadis D, Sackey E, Riches K, van Zanten M, Brice G, England R, Mills M, Dobbins SE, Lee LL; Lipoedema Consortium; Genomics England Research Consortium, Jeffery S, Dong L, Savage DB, Mortimer PS, Keeley V, Pittman A, Gordon K, Ostergaard P. Investigation of clinical characteristics and genome associations in the ‘UK Lipoedema’ cohort. PLoS One. 2022 Oct 13;17(10):e0274867. doi: 10.1371/journal.pone.0274867. PMID:36227936 PMCID:PMC9560129
Guccio N, Gribble FM, Reimann F. Glucose-Dependent Insulinotropic Polypeptide-A Postprandial Hormone with Unharnessed Metabolic Potential. Annu Rev Nutr. 2022 May 24. doi: 10.1146/annurev-nutr-062320-113625. PMID:35609956
Hall KD, Farooqi IS, Friedman JM, Klein S, Loos RJF, Mangelsdorf DJ, O’Rahilly S, Ravussin E, Redman LM, Ryan DH, Speakman JR, Tobias DK. The energy balance model of obesity: beyond calories in, calories out. Am J Clin Nutr. 2022 Feb 4:nqac031. doi: 10.1093/ajcn/nqac031. PMID:35134825
Hall KD, Farooqi IS, Friedman JM, Klein S, Loos RJF, Mangelsdorf DJ, O’Rahilly S, Ravussin E, Redman LM, Ryan DH, Speakman JR, Tobias DK. Reply to Taubes, Friedman, and Torres-Carot et al. Am J Clin Nutr. 2022 Jun 8:nqac163. doi: 10.1093/ajcn/nqac163. PMID:35675318
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2021

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Ahmed RM, Tse Ny, Chen Y, Henning E, Hodges JR, Kiernan MC, Irish M, Farooqi IS, Piguet O. Neural correlates of fat preference in frontotemporal dementia: translating insights from the obesity literature. Ann Clin Transl Neurol. 2021 Jun;8(6):1318-1329. doi: 10.1002/acn.51369. PMID:33973740
Andrade S, Morais T, Sandovici I, Seabra AL, Constância M, Monteiro MP. Adipose Tissue Epigenetic Profile in Obesity-Related Dysglycemia – A Systematic Review. Front Endocrinol (Lausanne). 2021 Jun 29;12:681649. doi: 10.3389/fendo.2021.681649. PMID:34290669 PMCID:PMC8288106
Angiolini E, Sandovici I, Coan PM, Burton GJ, Sibley CP, Fowden AL, Constância M. Deletion of the Imprinted Phlda2 Gene Increases Placental Passive Permeability in the Mouse. Genes (Basel). 2021 Apr 25;12(5):639. doi: 10.3390/genes12050639. PMID:33922969 PMCID:PMC8146920
Artero-Castro A, Long K, Bassett A, Avila-Fernandez A, Corton M, Vidal-Puig A, Jendelova P, Rodriguez-Jimenez FJ, Clemente E, Ayuso C, Slaven E, Gene Correction Recovers Phagocytosis in Retinal Pigment Epithelium Derived from Retinitis Pigmentosa-Human-Induced Pluripotent Stem Cells. Int J Mol Sci. 2021 Feb 20;22(4):2092. doi: 10.3390/ijms22042092. PMID:33672445 PMCID:PMC7923278
Asami M, Lam BYH, Ma MK, Rainbow K, Braun S, VerMilyea MD, Yeo GSH, Perry ACF. Human embryonic genome activation initiates at the one-cell stage. Cell Stem Cell. 2021 Dec 17;S1934-5909(21)00484-7. doi: 10.1016/j.stem.2021.11.012. PMID:34936886
Ayer A, Fazakerley DJ, James DE, Stocker R. The role of mitochondrial reactive oxygen species in insulin resistance. Free Radic Biol Med. 2021 Nov 11:S0891-5849(21)00794-2. doi: 10.1016/j.freeradbiomed.2021.11.007. PMID:34775001
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Azzu V, Vacca M, Kamzolas I, Hall Z, Leslie J, Carobbio S, Virtue S, Virtue S, Davies SE, Lukasik A, Dale M, Bohlooly-Y M, Acharjee A, Linden D, Bidault G, Petsalaki E, Griffin JL, Oakley F, Allison ME, Vidal-Puig A. Suppression of insulin-induced gene 1 (INSIG1) function promotes hepatic lipid remodelling and restrains NASH progression. Mol Metab. 2021 Mar 12:101210. doi: 10.1016/jmolmet.2021.101210. PMID:33722690
Bashari WA, Senanayake R, MacFarlane J, Gillett D, Powlson AS, Kolias A, Mannion RJ, Koulouri O, Gurnell M. Using Molecular Imaging to Enhance Decision Making in the Management of Pituitary Adenomas. J Nucl Med. 2021 Jul;62(Suppl 2):57S-62S. doi: 10.2967/jnumed.120.251546. PMID:34230075
Beardsall K, Thomson L, Guy C, Bond S, Allison A, Pantaleo B, Petrou S, Kim S, Dunger D, Hovorka R. Continuous glucose monitoring in extremely preterm infants in intensive care: the REACT RCT and pilot study of ‘closed-loop’ technology. Southampton (UK): NIHR Journals Library; 2021 Oct. PMID:34723449
Beardsall K, Thomason L, Guy C, Iglesias-Platas I, van Weissenbruch MM, Bond S, Allison A, Kim S, Petrou S, Pantaleo B, Hovorka R, Dunger D; REACT collaborative. Real-time continuous glucose monitoring in preterm infants (REACT): an international, open-label, randomised controlled trial. Lancet Child Adolesc Health. 2021 Feb 9:S2352-4642(20)30367-9. doi: 10.1016/S2352(20)30367-9. PMID:33577770
Bidault G, Virtue S, Petkevicius K, Jolin HE, Dugourd A, Guénantin AC, Leggat J, Mahler-Araujo B, Lam BYH, Ma MK, Dale M, Carobbio S, Kaser A, Fallon PG, Saez-Rodriguez J, McKenzie ANJ, Vidal-Puig A. SREBP1-induced fatty acid synthesis depletes macrophages antioxidant defences to promote their alternative activation. Nat Metab. 2021 Sep 16. doi: 10.1038/s42255-021-00440-5. PMID:34531575
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Bertozzi TM, Becker JL, Blake GET, Bansal A, Nguyen DK, Fernandez-Twinn DS, Ozanne SE, Bartolomei MS, Simmons RA, Watson ED, Ferguson-Smith AC. Variably methylated retrotransposons are refractory to a range of environmental perturbations. Nat Genet. 2021 Aug;53(8):1233-1242. doi: 10.1038/s41588-021-00898-9. PMID:34326545
Boughton CK, Daly A, Thabit H, Hartnell S, Herzig D, Vogt A, Ruan Y, Wilinska ME, Evans ML, Coll AP, Bally L, Hovorka R. Day-to-day variability of insulin requirements in the inpatient setting: observations during fully closed-loop insulin delivery. Diabetes Obes Metab. 2021 Apr 6. doi: 10.1111/dom.14396. PMID33822461
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Boughton CK, Tripyla A, Hartnell S, Daly A, Herzig D, Wilinska ME, Czerlau C, Fry A, Bally L, Hovorka R. Fully automated closed-loop glucose control compared with standard insulin therapy in adults with type 2 diabetes requiring dialysis: an open-label, randomized crossover trial. Nat Med. 2021 Aug;27(8):1471-1476. doi: 10.1038/s41591-021-01453-z. PMID:34349267 PMCID:PMC8363503
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Sam AH, Wilson R, Westacott R, Gurnell M, Melville C, Brown CA. Thinking differently – Students’ cognitive processes when answering two different formats of written question. Med Teach. 2021 Jun 14:1-8. doi: 10.1080/0142159X.2021.1935831. PMID:34126840
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Schoonejans JM, Blackmore HL, Ashmore TJ, Aiken CE, Fernandez-Twinn DS, Ozanne SE. Maternal Metformin Intervention during Obese Glucose-Intolerant Pregnancy Affects Adiposity in Young Adult Mouse Offspring in a Sex-Specific Manner. Int J Mol Sci. 2021 Jul 28;22(15):8104. doi: 10.3390/ijms22158104. PMID:34360870 PMCID:PMC8347264
Schoonejans JM, Ozanne SE. Developmental programming by maternal obesity: Lessons from animal models. Diabet Med. 2021 Sep 23;e14694. doi: 10.1111/dme.14694. PMID:34553414
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Senanayake R, Gillett D, MacFarlane J, Van de Meulen M, Powlson A, Koulouri O, Casey R, Bashari W, Gurnell M. New types of localization methods for adrenocorticotropic hormone-dependent Cushing’s syndrome. Best Pract Res Clin Endocrinol Metab. 2021 Jan;35(1):101513. PMID:34045044
Spiroski AM, Niu Y, Nicholas LM, Austin-Williams S, Camm EJ, Sutherland MR, Ashmore TJ, Skeffington KL, Logan A, Ozanne SE, Murphy MP, Giussani DA. Mitochondria antioxidant protection against cardiovascular dysfunction programmed by early-onset gestational hypoxia. FASEB J. 2021 May;35(5):e21446. doi: 10.1096/fj.202002705R. PMID:33788974
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Tarry-Adkins JL, Grant ID, Ozanne SE, Reynolds RM, Aiken CE. Efficacy and Side Effect Profile of Different Formulations of Metformin: A Systematic Review and Meta-Analysis. Diabetes Ther. 2021 Jun 2. doi: 10.1007/s13300-021-01058-2. PMID:34075573
Tarry-Adkins JL, Ozanne SE, Aiken CE. Impact of metformin treatment during pregnancy on maternal outcomes: a systematic review/meta-analysis. Sci Rep. 2021 Apr 29;11(1):9240. doi: 10.1038/s41598-021-88650-5. PMID:33927270 PMCID:PMC8085032
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Torok ME, Underwood BR, Toshner M, Waddington C, Sidhom E, Sharrocks K, Bousfield R, Summers C, Saunders C, McIntyre Z, Morris H, Piper J, Calderon G, Dennis S, Assari T, Marguerie de Rotrou A, Shaw A, Bradley J, O’Brien J, Rintoul RC, Smith I, Bullmore E, Chatterjee K and on behalf of the Cambridge COVID vaccine trial team. Challenges and opportunities for conducting a vaccine trial during the COVID-19 pandemic in the United Kingdom. Clinical Trials 2021. https://doi.org/10.1177/17407745211024764. PMID:34154428
Tritos NA, Fazeli PK, McCormack A, Mallea-Gil SM, Pineyro MM, Christ-Crain M, Frara S, Labadzhyan A, Ioachimescu AG, Shimon I, Takahashi Y, Gurnell M, Fleseriu M; “Pituitary Society Delphi Collaborative Group”. Pituitary Society Delphi Survey: An international perspective on endocrine management of patients undergoing transsphenoidal surgery for pituitary adenomas. Pituitary. 2021 Jul 20:1-10. doi: 10.1007/s11102-021-01170-3. PMID:34283370 PMCID:PMC8294287
Tundidor D, Meek CL, Yamamoto J, Martínez-Bru C, Gich I, Feig DS, Murphy HR, Corcoy R; CONCEPTT Collaborative Group. Continuous Glucose Monitoring Time-in-Range and HbA 1c Targets in Pregnant Women with Type 1 Diabetes. Diabetes Technol Ther. 2021 May 25. doi: 10.1089/dia.2021.0073. PMID:33945304
van Beijsterveldt IALP, Snowden SG, Myers PN, de Fluiter KS, van de Heijning B, Brix S, Ong KK, Dunger DB, Hokken-Koelega ACS, Koulman A. Metabolomics in early life and the association with body composition at age 2 years. Pediatr Obes. 2021 Oct 13;e12859. doi: 10.1111/ijpo.12859. PMID:34644810
van Geest FS, Groeneweg S, van den Akker ELT, Bacos I, Barca D, van den Berg SAA, Bertini E, Brunner D, Brunetti-Pierri N, Cappa M, Cappuccio G, Chatterjee K, Chesover AD, Christian P, Coutant R, Craiu D, Crock P, Dewey C, Dica A, Dimitri P, Dubey R, Enderli A, Fairchild J, Gallichan J, Garibaldi LR, George B, Hackenberg A, Heinrich B, Huynh T, Kłosowska A, Lawson-Yuen A, Linder-Lucht M, Lyons G, Lora FM, Moran C, Müller KE, Paone L, Paul PG, Polak M, Porta F, Reinauer C, de Rijke YB, Seckold R, Menevşe TS, Simm P, Simon A, Spada M, Stoupa A, Szeifert L, Tonduti D, van Toor H, Turan S, Vanderniet J, de Waart M, van der Wal R, van der Walt A, van Wermeskerken AM, Wierzba J, Zibordi F, Zung A, Peeters RP, Visser WE. Long-term efficacy of T3 analogue Triac in children and adults with MCT8 deficiency: a real-life retrospective cohort study. J Clin Endocrinol Metab. 2021 Oct 22:dgab750. doi: 10.1210/clinem/dgab750. PMID:34679181
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Virtue S, Lelliott CJ, Vidal-Puig A.What is the most appropriate covariate in ANCOVA when analysing metabolic rate? Nat Metab. 2021 Dec;3(12):1585. doi: 10.1038/s42255-021-00505-5. PMID:34903886
Virtue S, Vidal-Puig A. GTTs and ITTs in mice: simple tests, complex answers. Nat Metab. 2021 Jun 11. doi: 10.1038/s42255-021-00414-7. PMID:34117483
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Westwater ML, Mancini F, Gorka AX, Shapleske J, Serfontein J, Grillon C, Ernst M, Ziauddeen H, Fletcher PC. Prefrontal responses during proactive and reactive inhibition are differentially impacted by stress in anorexia and bulimia nervosa. J Neurosci. 2021 Apr 12:JN-RM-2853-20. doi: 10.1523/JNEUROSCI.2853-20.2021. PMID:33846229
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Woodward OR, Gribble FM, Reimann F, Lewis JE. Gut peptide regulation of food intake – evidence for the modulation of hedonic feeding. J Physiol. 2021 Jun 21. doi: 10.1113/JP280581. PMID:34152020
Wylie TA, Shah C, Burgess L, Robertson E, Dupont D, Swindell R, Hovorka R, Murphy HR, Heller SR. Optimising the use of technology to support people with diabetes: research recommendations from Diabetes UK’s 2019 diabetes and technology workshop. Diabet Med. 2021 Jul 16:e14647. doi: 10.1111/dme.14647. PMID:34270822
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2020

Alligier M, Barrès R, Blaak EE, Boirie Y, Bouwman J, Brunault P, Campbell K, Clément K, Farooqi IS, Farpour-Lambert NJ, Frühbeck G, Goossens GH, Hager J, Halford JCG, Hauner H, Jacobi D, Julia C, Langin D, Natali A, Neovius M, Oppert JM, Pagotto U, Palmeira AL, Roche H, Rydén M, Scheen AJ, Simon C, Sorensen TIA,Tappy L, Yki-Järvinen H, Ziegler O, Laville M. OBEDIS Core Variables roject: European Expert Guidelines on a Minimal Core Set of Variables to Include in Randomized, Controlled Clinical Trials of Obesity Interventions. Obes Facts. 2020 Jan 13:1-28. Epub ahead of print. PubMed PMID: 31945762. PMCID: PMC7098277.
Anstee QM, Darlay R, Cockell S, Meroni M, Govaere O, Tiniakos D, Burt AD, Bedossa P, Palmer J, Liu YL, Aithal GP, Allison M, Yki-Järvinen H, Vacca M, Dufour JF, Invernizzi P, Prati D, Ekstedt M, Kechagias S, Francque S, Petta S, Bugianesi E, Clement K, Ratziu V, Schattenberg JM, Valenti L, Day CP, Cordell HJ, Daly AK; EPoS Consortium Investigators. Genome-wide Association Study of Non-Alcoholic Fatty Liver and Steatohepatitis in a Histologically-Characterised Cohort. Journal of Hepatology. 2020 Apr 13:S0168-8278(20)30213-0. PMID: 32298765.
Araiz C, Yan A, Bettedi L, Samuelson I, Virtue S, McGavigan AK, Dani C, Vidal-Puig A, Foukas LC. Publisher Correction: Enhanced β-Adrenergic Signalling Underlies an Age-Dependent Beneficial Metabolic Effect of PI3K p110α Inactivation in Adipose Tissue. Nat Commun. 2020 Feb 21;11(1):1078. PMID: 32081871.
Ast J, Arvaniti A, Fine NHF, Nasteska D, Ashford FB, Stamataki Z, Koszegi Z, Bacon A, Jones BJ, Lucey MA, Sasaki S, Brierley DI, Hastoy B, Tomas A, D’Agostino G, Reimann F, Lynn FC, Reissaus CA, Linnemann AK, D’Este E, Calebiro D, Trapp S, Johnsson K, Podewin T, Broichha- gen J, Hodson DJ. Author Correction: Super-resolution microscopy compatible fluorescent probes reveal endogenous glucagon-like peptide-1 receptor distribution and dynamics. Nat Commun. 2020 Oct 9;11(1):5160. PMID: 33037231.
Azzu V, Vacca M, Virtue S, Allison M, Vidal-Puig A. Adipose tissue-liver cross talk in the control of whole-body metabolism: implications in non-alcoholic fatty liver disease. Gastroenterology. 2020 Feb 12. pii: S0016-5085(20)30224-9. Epub ahead of print. PMID: 32061598.
Baig S, Shabeer M, Parvaresh Rizi E, Agarwal M, Lee MH, Ooi DSQ, Chia C, Aung N, Ng G, Teo Y, Chhay V, Magkos F, Vidal-Puig A, Seet RCS, Toh SA. Heredity of type 2 diabetes confers increased susceptibility to oxidative stress and inflammation. BMJ Open Diabetes Res Care. 2020 Jan;8(1). PMID: 32049633. PMCID: PMC7039582.
Banholzer N, Herzig D, Piazza C, Álvarez-Martínez M, Nakas CT, Kosinski C, Feuerriegel S, Hovorka R, Bally L. Effect of nutrition on postprandial glucose control in hospitalized patients with type 2 diabetes receiving fully automated closed-loop insulin therapy. Diabetes Obes Metab. 2020 Sep 4. PMID: 32885596.
Bashari WA, Senanayake R, Koulouri O, Gillett D, MacFarlane J, Powlson AS, FernandezPombo A, Bano G, Martin AJ, Scoffings D, Cheow H, Mendichovszky I, Tysome J, Donnelly N, Santarius T, Kolias A, Mannion R, Gurnell M. PET-guided Repeat Transsphenoidal Surgery for Previously Deemed Unresectable Lateral Disease in Acromegaly. Neurosurgical Focus. 2020 Jun;48(6):E8. PMID: 32480379.
Bernstein RM, O’Connor GK, Vance EA, Affara N, Drammeh S, Dunger DB, Faal A, Ong KK, Sosseh F, Prentice AM, Moore SE. Timing of the Infancy-Childhood Growth Transition in Rural Gambia. Frontiers of Endocrinology (Lausanne). 2020 Mar 24;11:142. PMID: 32265838 PMCID: PMC7105771.
Blackwell AKM, De-Loyde K, Brocklebank LA, Maynard OM, Marteau TM, Hollands GJ, Fletcher PC, Attwood AS, Morris RW, Munafò MR. Tobacco and electronic cigarette cues for smoking and vaping: an online experimental study. BMC Res Notes. 2020 Jan 15;13(1):32. PubMed PMID:31941548; PubMed Central PMCID: PMC6964108.
Blackwell AKM, De-Loyde K, Hollands GJ, Morris RW, Brocklebank LA, Maynard OM, Fletcher PC, Marteau TM, Munafò MR. The Impact on Selection of Non-Alcoholic vs Alcoholic Drink Availability: An Online Experiment. BMC Public Health. 2020 May 6;20(1):526. PMID: 32370760 PMCID: PMC7201696.
Blastland M, Freeman ALJ, van der Linden S, Marteau TM, Spiegelhalter D. Five rules for evidence communication. Nature. 2020 Nov;587(7834):362-364. doi: 10.1038/d41586-020-03189-1. PMID: 33208954.
Boughton C, Allen JM, Tauschmann M, Hartnell S, Wilinska ME, Musolino G, Acerini CL, Dunger PD, Campbell F, Ghatak A, Randell T, Besser R, Trevelyan N, Elleri D, Northam E, Hood K, Scott E, Lawton J, Roze S, Sibayan J, Kollman C, Cohen N, Todd J, Hovorka R; CLOuD Consortium. Assessing the effect of closed-loop insulin delivery from onset of type 1 diabetes in youth on residual beta-cell function compared to standard insulin therapy (CLOuD study): a randomised parallel study protocol. BMJ Open. 2020 Mar 12;10(3):e033500. PMID: 32169925; PMCID: PMC7069267.
Boughton CK, Hartnell S, Allen JM, Fuchs J, Hovorka R. Training and Support for Hybrid Closed -Loop Therapy. J Diabetes Sci Technol. 2020 Sep 11;1932296820955168. PMID: 32914648.
Boughton CK, Hovorka R. The artificial pancreas. Curr Opin Organ Transplant. 2020 Aug;25 (4):336-342. PMID: 32618719.
Braukmann F, Jordan D, Jenkins B, Koulman A, Miska EA. SID-2 negatively regulates develop- ment likely independent of nutritional dsRNA uptake. RNA Biol. 2020 Oct 12;1-12. PMID: 33044912.
Brierley GV, Webber H,2 Rasijeff E, Grocott S, Siddle K, Semple RK. Anti-Insulin Receptor Anti- bodies Improve Hyperglycemia in a Mouse Model of Human Insulin Receptoropathy. Diabetes 2020;69:1–9. PMID: 32816962.
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Mahú I, Barateiro A, Rial-Pensado E, Martinéz-Sánchez N, Vaz SH, Cal PMSD, Jenkins B, Rodrigues T, Cordeiro C, Costa MF, Mendes R, Seixas E, Pereira MMA, Kubasova N, Gres V, Morris I, Temporão C, Olivares M, Sanz Y, Koulman A, Corzana F, Sebastião AM, López M, Bernardes GJL, Domingos AI. Brain-Sparing Sympathofacilitators Mitigate Obesity Without Adverse Cardiovascular Effects. Cell Metabolism. 2020 Jun 2;31(6):1120-1135.e7. PMID: 32402266.
Marcovecchio ML, Colombo M, Dalton RN, McKeigue PM, Benitez-Aguirre P, Cameron F, Chiesa ST, Couper J, Craig M, Daneman D, Davis E, Deanfield J, Donaghue K, Jones TW, Mahmud FH, Marshall SM, Neil HAW, Colhoun HM, Dunger DB; AdDIT and the SDRNT1BIO Investigators. Biomarkers associated with early stages of kidney disease in adolescents with type 1 diabetes. Pediatr Diabetes. 2020 Aug 11. PMID: 32783254.
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Marcovecchio ML, Wicker LS, Dunger DB, Dutton SJ, Kopijasz S, Scudder C, Todd JA, Johnson PRV. Interleukin-2 Therapy of Autoimmunity in Diabetes (ITAD): A Phase 2, Multicentre, DoubleBlind, Randomized, Placebo-Controlled Trial. Wellcome Open Res. 2020 Mar 20;5:49. PMID: 32399500. PMCID: PMC7194454.
Marenne G, Hendricks AE, Perdikari A, Bounds R, Payne F, Keogh JM, Lelliott CJ, Henning E, Pathan S, Ashford S, Bochukova EG, Mistry V, Daly A, Hayward C; INTERVAL, UK10K Consortium, Wareham NJ, O’Rahilly S, Langenberg C, Wheeler E, Zeggini E, Farooqi IS, Barroso I. Exome Sequencing Identifies Genes and Gene Sets Contributing to Severe Childhood Obesity, Linking PHIP Variants to Repressed POMC Transcription. Cell Metabolism. 2020 Jun 2;31 (6):1107-1119.e12. PMID: 32492392.
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2019

Adriaensses A; Gribble FM; Reimann F. The glucose-dependent insulinotropic polypeptide signalling axis in the central nervous system. Peptides. 2020 Mar;125:170194. Epub 2019 Nov 4. Review. PMID: 31697967
Adriaenssens AE, Biggs EK, Darwish T, Tadross J, Sukthankar T, Girish M, Polex-Wolf J, Lam BY, Zvetkova I, Pan W, Chiarugi D, Yeo GSH, Blouet C, Gribble FM, Reimann F. GlucoseDependent Insulinotropic Polypeptide Receptor-Expressing Cells in the Hypothalamus Regulate Food Intake. Cell Metab. 2019 Aug 19. [Epub ahead of print] PMID: 31447324.
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Aiken CEM, Hone L, Murphy HR, Meek CL. Improving outcomes in gestational diabetes: does gestational weight gain matter? Diabet Med. 2019 Feb;36(2):167-176. doi: 10.1111/dme.13767. PMID:29932243
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Aiken CE, Tarry-Adkins JL, Spiroski AM, Nuzzo AM, Ashmore TJ, Rolfo A, Sutherland MJ, Camm EJ, Giussani DA, Ozanne SE. Chronic gestational hypoxia accelerates ovarian aging and lowers ovarian reserve in next-generation adult rats. FASEB J. 2019 Jun;33(6):7758-7766. doi: 10.1096/fj.201802772R. Epub 2019 Mar 19. PMID: 30888848 PMCID: PMC6529349
Ajjaji D, Ben M’barek K, Mimmack ML, England C, Herscovitz H, Dong L, Kay RG, Patel S, Saudek V, Small DM, Savage DB, Thiam AR. Dual binding motifs underpin the hierarchical association of perilipins1 -3 with lipid droplets. Mol Biol Cell. 2019 Mar 1;30(5):703-716. doi: 10.1091/mbc.E18-08-0534. Epub 2019 Jan 16. PMID: 30649995 PMCID: PMC6589688
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Lotta LA, Mokrosiński J, Mendes de Oliveira E, Li C, Sharp SJ, Luan J, Brouwers B, Ayinampudi V, Bowker N, Kerrison N, Kaimakis V, Hoult D, Stewart ID, Wheeler E, Day FR, Perry JRB, Langenberg C, Wareham NJ, Farooqi IS. Human Gain-of-Function MC4R Variants Show Signaling Bias and Protect against Obesity. Cell. 2019 Apr 18;177(3):597-607.e9. PMID:31002796; PMCID: PMC6476272
Lu VB, Rievaj J, O’Flaherty EA, Smith CA, Pais R, Pattison LA, Tolhurst G, Leiter AB, Bulmer DC, Gribble FM, Reimann F. Adenosine triphosphate is co-secreted with glucagon-like peptide-1 to modulate intestinal enterocytes and afferent neurons. Nat Commun. 2019 Mar 4;10(1):1029. doi: 10.1038/s41467-019-09045-9. PMID: 30833673 PMCID: PMC6399286
Macaulay S, Buchmann EJ, Dunger DB, Norris SA. Reliability and validity of last menstrual period for gestational age estimation in a low-to-middle-income setting. J Obstet Gynaecol Res. 2019 Jan;45(1):217-225. doi: 10.1111/jog.13801. Epub 2018 Sep 6. PMID: 30191629
Maniero C, Scudieri P, Haris Shaikh L, Zhao W, Gurnell M, Galietta LJV, Brown MJ. ANO4 (Anoctamin 4) Is a Novel Marker of Zona Glomerulosa That Regulates Stimulated Aldosterone Secretion. Hypertension. 2019 Nov;74(5):1152-1159. PMID: 31564164.
Mann JP, Savage DB. What lipodystrophies teach us about the metabolic syndrome. J Clin Invest. 2019 Aug 5;130:4009-4021. Review. PMID: 31380809.
Marcovecchio ML, Dalton RN, Daneman D, Deanfield J, Jones TW, Neil HAW, Dunger DB; Adolescent type 1 Diabetes cardio-renal Intervention Trial (AdDIT) study group. A new strategy for vascular complications in young people with type 1 diabetes mellitus. Nat Rev Endocrinol. 2019 Jul;15(7):429-435. Review. PMID:30996294
Mazarello Paes V, Barrett JK, Taylor-Robinson DC, Chesters H, Charalampopoulos D, Dunger DB, Viner RM, Stephenson TJ. Effect of early glycemic control on HbA1c tracking and development of vascular complications after 5 years of childhood onset type 1 diabetes: Systematic review and meta -analysis. Pediatr Diabetes. 2019 Aug;20(5):494-509. Epub 2019 Apr 24. Review. PMID:30932298; PMCID:PMC6701989
Medic N, Kochunov P, Ziauddeen H, Ersche KD, Nathan PJ, Ronan L, Fletcher PC. BMI-related cortical morphometry changes are associated with altered white matter structure. Int J Obes (Lond). 2019 Mar;43(3):523-532. PMID: 30568264 PMCID: PMC6462878
Melvin A, Lacerda E, Dockrell S M, O’Rahilly S, Nacul L. Circulating levels of GDF15 in patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. J Transl Med. 2019 Dec 4;17 (1):409. PMID: 31801546. PMCID: PMC6892232
Melvin A, Stears A, Savage DB. Recent developments in lipodystrophy. Curr Opin Lipidol. 2019 Aug;30(4):284-290. PMID: 31135595.
Menting MD, Mintjens S, van de Beek C, Frick CJ, Ozanne SE, Limpens J, Roseboom TJ, Hooijmans CR, van Deutekom AW, Painter RC. Maternal obesity in pregnancy impacts offspring cardiometabolic health: Systematic review and meta-analysis of animal studies. Obes Rev. 2019 May;20(5):675-685. doi: 10.1111/obr.12817. PMID: 30633422 PMCID: PMC6849816
Menzies-Gow A, Corren J, Bel EH, Maspero J, Heaney LG, Gurnell M, Wessman P, Martin UJ, Siddiqui S, Garcia Gil E. Corticosteroid tapering with benralizumab treatment for eosinophilic asthma: PONENTE Trial. ERJ Open Res. 2019 Sep 25;5(3). PMID: 31579676.
Müller TD, Finan B, Bloom SR, D’Alessio D, Drucker DJ, Flatt PR, Fritsche A, Gribble F, Grill HJ, Habener JF, Holst JJ, Langhans W, Meier JJ, Nauck MA, Perez-Tilve D, Pocai A, Reimann F, Sandoval DA, Schwartz TW, Seeley RJ, Stemmer K, Tang-Christensen M, Woods SC, DiMarchi RD, Tschöp MH. Glucagon-like peptide 1 (GLP-1). Mol Metab. 2019 Dec;30:72-130. Epub 2019 Sep 30. Review. PMID: 31767182. PMCID: PMC6812410.
Musial B, Fernandez-Twinn DS, Duque-Guimaraes D, Carr SK, Fowden AL, Ozanne SE, Sferruzzi-Perri AN. Exercise alters the molecular pathways of insulin signaling and lipid handling in maternal tissues of obese pregnant mice. Physiol Rep. 2019 Aug;7(16). PMID: 31466137.
Musolino G, Allen JM, Hartnell S, Wilinska ME, Tauschmann M, Boughton C, Campbell F, Denvir L, Trevelyan N, Wadwa P, DiMeglio L, Buckingham BA, Weinzimer S, Acerini CL, Hood K, Fox S, Kollman C, Sibayan J, Borgman S, Cheng P, Hovorka R. Assessing the efficacy, safety and utility of 6-month day-and-night automated closed-loop insulin delivery under free-living conditions compared with insulin pump therapy in children and adolescents with type 1 diabetes: an open-label, multicentre, multinational, single-period, randomised, parallel group study protocol. BMJ Open. 2019 Jun 3;9(6):e027856. PMID:31164368; PMCID: PMC6561428
Musolino G, Dovc K, Boughton CK, Tauschmann M, Allen JM, Nagl K, Fritsch M, Yong J, Metcalfe E, Schaeffer D, Fichelle M, Schierloh U, Thiele AG, Abt D, Kojzar H, Mader JK, Slegtenhorst S, Ashcroft N, Wilinska ME, Sibayan J, Cohen N, Kollman C, Hofer SE, Fröhlich -Reiterer E, Kapellen TM, Acerini CL, de Beaufort C, Campbell F, Rami-Merhar B, Hovorka R; Kidsap Consortium. Reduced burden of diabetes and improved quality of life: Experiences from unrestricted day-and-night hybrid closed-loop use in very young children with type 1 diabetes. Pediatr Diabetes. 2019 May 29. [Epub ahead of print] PMID:31140654; PMCID:PMC6771658
Nicholas LM, Ozanne SE. Early life programming in mice by maternal overnutrition: mechanistic insights and interventional approaches. Philos Trans R Soc Lond B Biol Sci. 2019 Apr 15;374(1770):20180116. PMID:30966886; PMCID:PMC6460073
Nyimanu D, Kay RG, Sulentic P, Kuc RE, Ambery P, Jermutus L, Reimann F, Gribble FM, Cheriyan J, Maguire JJ, Davenport AP. Development and validation of an LC-MS/MS method for detection and quantification of in vivo derived metabolites of [Pyr(1)]apelin-13 in humans. Sci Rep. 2019 Dec 27;9(1):19934. PubMed PMID: 31882594; PubMed Central PMCID:PMC6934825.
Oral EA, Gorden P, Cochran E, Araújo-Vilar D, Savage DB, Long A, Fine G, Salinardi T, Brown RJ. Long -term effectiveness and safety of metreleptin in the treatment of patients with partial lipodystrophy. Endocrine. 2019 Jun;64(3):500-511. doi: 10.1007/s12020-019-01862-8. PMID: 30805888 PMCID: PMC7340120
Ortega FJ, Moreno-Navarrete JM, Mercader JM, Gómez-Serrano M, García-Santos E, Latorre J, Lluch A, Sabater M, Caballano-Infantes E, Guzmán R, Macías-González M, Buxo M, Gironés J, Vilallonga R, Naon D, Botas P, Delgado E, Corella D, Burcelin R, Frühbeck G, Ricart W, Simó R, Castrillon-Rodríguez I, Tinahones FJ, Bosch F, Vidal-Puig A, Malagón MM, Peral B, Zorzano A, Fernández-Real JM. Cytoskeletal transgelin 2 contributes to gender-dependent adipose tissue expandability and immune function. FASEB J. 2019 Aug;33(8):9656-9671. PMID: 31145872.
O’Shea PM, O’Donoghue D, Bashari W, Senanayake R, Joyce MB, Powlson AS, Browne D, O’Sullivan GJ, Cheow H, Mendichovszky I, Quill D, Lowery A, Lappin D, Gurnell M, Dennedy MC. 11 C-Metomidate PET/CT is a useful adjunct for lateralization of primary aldosteronism in routine clinical practice. Clin Endocrinol (Oxf). 2019 May;90(5):670-679. doi: 10.1111/cen.13942. Epub 2019 Mar 18. PMID: 30721535
Parkinson JRC, Emsley R, Adkins JLT, Longford N, Ozanne SE, Holmes E, Modi N. Clinical and molecular evidence of accelerated ageing following very preterm birth. Pediatr Res. 2019 Dec 7. Epub ahead of print. PMID: 31812156.
Patel S, Alvarez-Guaita A, Melvin A, Rimmington D, Dattilo A, Miedzybrodzka EL, Cimino I, Maurin AC, Roberts GP, Meek CL, Virtue S, Sparks LM, Parsons SA, Redman LM, Bray GA, Liou AP, Woods RM, Parry SA, Jeppesen PB, Kolnes AJ, Harding HP, Ron D, Vidal-Puig A, Reimann F, Gribble FM, Hulston CJ, Farooqi IS, Fafournoux P, Smith SR, Jensen J, Breen D, Wu Z, Zhang BB, Coll AP, Savage DB, O’Rahilly S. GDF15 Provides an Endocrine Signal of Nutritional Stress in Mice and Humans. Cell Metab. 2019 Mar 5;29(3):707-718.e8. PMID: 30639358 PMCID: PMC6408327
Patel V, Bidault G, Chambers JE, Carobbio S, Everden AJT, Garcés C, Dalton LE, Gribble FM, VidalPuig A, Marciniak SJ. Inactivation of Ppp1r15a minimises weight gain and insulin resistance during caloric excess in female mice. Sci Rep. 2019 Feb 27;9(1):2903. doi: 10.1038/s41598-019-39562-y. PMID: 30814564 PMCID: PMC6393541
Peters C, Nicholas AK, Schoenmakers E, Lyons G, Langham S, Serra EG, Sebire NJ, Muzza M, Fugazzola L, Schoenmakers N. DUOX2/DUOXA2 Mutations Frequently Cause Congenital Hypothyroidism that Evades Detection on Newborn Screening in the United Kingdom. Thyroid. 2019 Jun;29(6):790-801. PMID:31044655; PMCID:PMC6588112
Petkevicius K, Virtue S, Bidault G, Jenkins B, Çubuk C, Morgantini C, Aouadi M, Dopazo J, Serlie MJ, Koulman A, Vidal-Puig A. Accelerated phosphatidylcholine turnover in macrophages promotes adipose tissue inflammation in obesity. Elife. 2019 Aug 16;8. PMID: 31418690.
Petry CJ, Ong KK, Hughes IA, Acerini CL, Dunger DB. Age at Menarche and Blood Pressure in Pregnancy. Pregnancy Hypertens. 2019 Jan;15:134-140. PMID: 30713829 PMCID: PMC6352955
Prats-Puig A, Xargay-Torrent S, Carreras-Badosa G, Mas-Parés B, Bassols J, Petry CJ, Girardot M, D E Zegher F, Ibáñez L, Dunger DB, Feil R, López-Bermejo A. Methylation of the C19MC microRNA locus in the placenta: association with maternal and chilhood body size. Int J Obes (Lond). 2019 Sep 25. [Epub ahead of print] PMID: 31554916.
Prentice PM, Olga L, Petry CJ, Simmons D, Murphy HR, Hughes IA, Acerini CL, Ong KK, Dunger DB. Reduced size at birth and persisting reductions in adiposity in recent, compared with earlier, cohorts of infants born to mothers with gestational diabetes mellitus. Diabetologia. 2019 Nov;62(11):1977-1987. Epub 2019 Aug 9. PubMed PMID: 31396660; PubMed Central PMCID: 6805804.
Prentice PM, Schoemaker MH, Vervoort J, Hettinga K, Lambers TT, van Tol EAF, Acerini CL, Olga L, Petry CJ, Hughes IA, Koulman A, Ong KK, Dunger DB. Human Milk Short-Chain Fatty Acid Composition is Associated with Adiposity Outcomes in Infants. J Nutr. 2019 May 1;149(5):716-722. PMID:31050748
Rana BMJ, Jou E, Barlow JL, Rodriguez-Rodriguez N, Walker JA, Knox C, Jolin HE, Hardman CS, Sivasubramaniam M, Szeto A, Cohen ES, Scott IC, Sleeman MA, Chidomere CI, Cruz Migoni S, Caamano J, Jorgensen HF, Carobbio S, Vidal-Puig A, McKenzie ANJ. A stromal cell niche sustains ILC2-mediated type-2 conditioning in adipose tissue. J Exp Med. 2019 Sep 2;216 (9):1999-2009. PMID: 31248899.
Razolli D, de Araújo T, Sant’Ana M, Kirwan P, Cintra D, Merkle F, Velloso L. POMC processing in the hypothalamus is directly regulated by saturated fat – implications for the development of obesity. Neuroendocrinology. 2019 May 20. [Epub ahead of print]. PMID: 31104058
Reimann F; Diakogiannaki E; Moss C E; Gribble F M. Cellular mechanisms governing Glucosedependent insulinotropic polypeptide secretion. Peptides. 2020 Mar;125:170206 170206. Epub 2019 Nov 19. Review. PubMed PMID: 31756367.
Riveros-McKay F, Mistry V, Bounds R, Hendricks A, Keogh JM, Thomas H, Henning E, Corbin LJ; Understanding Society Scientific Group, O’Rahilly S, Zeggini E, Wheeler E, Barroso I, Farooqi IS. Genetic architecture of human thinness compared to severe obesity. PLoS Genet. 2019 Jan 24;15(1):e1007603. PMID: 30677029 PMCID: PMC6345421
Roberts GP, Larraufie P, Richards P, Kay RG, Galvin SG, Miedzybrodzka EL, Leiter A, Li HJ, Glass LL, Ma MKL, Lam B, Yeo GSH, Scharfmann R, Chiarugi D, Hardwick RH, Reimann F, Gribble FM. Comparison of Human and Murine Enteroendocrine Cells by Transcriptomic and Peptidomic Profiling. Diabetes. 2019 May;68(5):1062-1072. doi: 10.2337/db18-0883. Epub 2019 Feb 7. PMID: 30733330
Rodriguez-Cuenca S, Carobbio S, Barceló-Coblijn G, Prieur X, Relat J, Amat R, Campbell M, Dias AR, Bahri M, Gray SL, Vidal-Puig A. P465L-PPARγ mutation confers partial resistance to the hypolipidaemic action of fibrates. Diabetes Obes Metab. 2018 Oct;20(10):2339-2350. doi: 10.1111/dom.13370. PMID:29790245 PMCID:PMC6589924
Ronan L, Alexander-Bloch A, Fletcher PC. Childhood Obesity, Cortical Structure, and Executive Function in Healthy Children. Cereb Cortex. 2019 Oct 24. [Epub ahead of print] PMID: 31646343.
Ruan Y, Willemsen RH, Wilinska ME, Tauschmann M, Dunger DB, Hovorka R. Mixed-meal tolerance test to assess residual beta-cell secretion: Beyond the area-under-curve of plasma C-peptide concentration. Pediatr Diabetes. 2019 May;20(3):282-285. doi: 10.1111/pedi.12816. PMID: 30652426 PMCID: PMC6487945
Savage DB, Watson L, Carr K, Adams C, Brage S, Chatterjee KK, Hodson L, Boesch C, Kemp GJ, Sleigh A. Accumulation of saturated intramyocellular lipid is associated with insulin resistance. J. Lipid Res. (2019) Jul;60(7):1323-1332. Epub 2019 May 2. PMID:31048405; PMCID:PMC6602127
Sefton C, Davies A, Allen TJ, Wray JR, Shoop R, Adamson A, Humphreys N, Coll AP, White A, Harno E. The metabolic abnormalities of chronic high dose glucocorticoids are not mediated by hypothalamic AgRP in male mice. Endocrinology. 2019 May 1;160(5):964-978. doi: 10.1210/en.2019-00018. PMID: 30794724 PMCID: PMC6444294
Schierloh U, Wilinska ME, Pit-Ten Cate IM, Baumann P, Hovorka R, De Beaufort C; Spidiman Study Group: Single Port Insulin Infusion for Improved Diabetes Management. Lower plasma insulin levels during overnight closed-loop in school children with type 1 diabetes: Potential advantage? A randomized cross-over trial. PLoS One. 2019 Mar 8;14(3):e0212013. doi: 10.1371/journal.pone.0212013. eCollection 2019. PMID: 30849076 PMCID: PMC6408001
Speight J, Holmes-Truscott E, Little SA, Leelarathna L, Walkinshaw E, Tan HK, Bowes A, Kerr D, Flanagan D, Heller SR, Evans ML, Shaw JAM. Satisfaction with the Use of Different Technologies for Insulin Delivery and Glucose Monitoring Among Adults with Long-Standing Type 1 Diabetes and Problematic Hypoglycemia: 2-Year Follow-Up in the HypoCOMPaSS Randomized Clinical Trial. Diabetes Technol Ther. 2019 Nov;21(11):619-626. PMID: 31335201.
Sutherland MJ, Camm EJ, Giussani DA, Ozanne SE. Chronic gestational hypoxia accelerates ovarian aging and lowers ovarian reserve in next-generation adult rats. FASEB J. 2019 Jun;33 (6):7758-7766. Epub 2019 Mar 19. PMID:30888848; PMCID:PMC6529349
Tarry-Adkins JL, Aiken CE, Ozanne SE. Neonatal, infant, and childhood growth following metformin versus insulin treatment for gestational diabetes: A systematic review and meta-analysis. PLoS Med. 2019 Aug 6;16(8):e1002848. PMID: 31386659.
Tarry-Adkins JL, Ozanne SE. Poor Early Growth and Age-Associated Disease. Subcell Biochem. 2019;91:1-19. PMID: 30888647
Tauschmann M, Allen JM, Nagl K, Fritsch M, Yong J, Metcalfe E, Schaeffer D, Fichelle M, Schierloh U, Thiele AG, Abt D, Kojzar H, Mader JK, Slegtenhorst S, Barber N, Wilinska ME, Boughton C, Musolino G, Sibayan J, Cohen N, Kollman C, Hofer SE, Fröhlich-Reiterer E, Kapellen TM, Acerini CL, de Beaufort C, Campbell F, Rami-Merhar B, Hovorka R; KidsAP Consortium. Home Use of Day-and-Night Hybrid Closed-Loop Insulin Delivery in Very Young Children: A Multicenter, 3-Week, Randomized Trial. Diabetes Care. 2019 Apr;42(4):594-600. doi: 10.2337/dc18-1881. Epub 2019 Jan 28. PMID: 30692242
Teulings NEWD, Masconi KL, Ozanne SE, Aiken CE, Wood AM. Effect of interpregnancy weight change on perinatal outcomes: systematic review and meta-analysis. BMC Pregnancy Childbirth. 2019 Oct 28;19(1):386. PMID: 31660893.
Thakar R, Gajewska-Knapik G, Ogilvy-Stuart AL, Chatterjee K, Moran C. Response to Letter to the Editor: “Alemtuzumab-induced thyroid dysfunction exhibits distinctive clinical and immunological features”. J.Clin. Endocrinol. Metab. (2019). PMID:30977836
Tschaikner M, Powell K, Jungklaus M, Fritz M, Ellmerer M, Hovorka R, Lane S, Pieber TR, Regittnig W. Novel Single-Site Device for Conjoined Glucose Sensing and Insulin Infusion: Performance Evaluation in Diabetes Patients During Home-Use. IEEE Trans Biomed Eng. 2019 Jun 27. [Epub ahead of print]. PMID:31251175
Turcot V, 39 authors, Barroso I, 65 authors, Farooqi IS, 293 authors, Loos RJF. Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity. Nat Genet. 2019 Jul;51(7):1191- 1192. PMID:31160809
van der Klaauw AA, Croizier S, Mendes de Oliveira E, Stadler LKJ, Park S, Kong Y, Banton MC, Tandon P, Hendricks AE, Keogh JM, Riley SE, Papadia S, Henning E, Bounds R, Bochukova EG, Mistry V, O’Rahilly S, Simerly RB; INTERVAL; UK10K Consortium, Minchin JEN, Barroso I, Jones EY, Bouret SG, Farooqi IS. Human Semaphorin 3 Variants Link Melanocortin Circuit Development and Energy Balance. Cell. 2019 Feb 7;176(4):729-742.e18. PMID: 30661757 PMCID: PMC6370916
Vargas-Castillo A, Tobon-Cornejo S, Del Valle-Mondragon L, Torre-Villalvazo I, SchcolnikCabrera A, Guevara-Cruz M, Pichardo-Ontiveros E, Fuentes-Romero R,Bader M, Alenina N, Vidal-Puig A, Hong E, Torres N, Tovar AR. Angiotensin-(1-7) induces beige fat thermogenesis through the Mas receptor. Metabolism. 2019 Dec 13;103:154048. Epub ahead of print. PubMed PMID: 31843339. PMCID: PMC7054746.
Vasiljevic M, Fuller G, Pilling M, Hollands GJ, Pechey R, Jebb SA, Marteau TM. What is the impact of increasing the prominence of calorie labelling? A stepped wedge randomised controlled pilot trial in worksite cafeterias. Appetite. 2019 Oct 1;141:104304. Epub 2019 May 29. PMID:31152762
Vergari E, Knudsen JG, Ramracheya R, Salehi A, Zhang Q, Adam J, Asterholm IW, Benrick A, Briant LJB, Chibalina MV, Gribble FM, Hamilton A, Hastoy B, Reimann F, Rorsman NJG, Spiliotis II, Tarasov A, Wu Y, Ashcroft FM, Rorsman P. Insulin inhibits glucagon release by SGLT2-induced stimulation of somatostatin secretion. Nat Commun. 2019 Jan 11;10(1):139. PMID: 30635569 PMCID: PMC6329806
Vestergaard ET, Hjelholt AJ, Kuhre RE, Møller N, Larraufie P, Gribble FM, Reimann F, Jessen N, Holst JJ, Jørgensen JOL. Acipimox Acutely Increases GLP-1 Concentrations in Overweight Subjects and Hypopituitary Patients. J Clin Endocrinol Metab. 2019 Jul 1;104(7):2581- 2592. PMID:30726969; PMCID:PMC7212086
Wallenius V, Elias E, Elebring E, et al. Suppression of enteroendocrine cell glucagon-like peptide (GLP)-1 release by fat-induced small intestinal ketogenesis: a mechanism targeted by Roux-enY gastric bypass surgery but not by preoperative very-low-calorie diet. Gut Published Online First: 21 November 2019. doi: 10.1136/gutjnl-2019-319372. PMID: 31753852.
Watson LPE, Carr KS, Venables MC, Acerini CL, Lyons G, Moran C, Murgatroyd PR, Chatterjee K. Quantifying energy expenditure in childhood: utility in managing pediatric metabolic disorders. Am J Clin Nutr. 2019 Nov 1;110(5):1186-1191. PMID: 31410443. PMCID: PMC6821543.
Wejaphikul K, Groeneweg S, Hilhorst-Hofstee Y, Chatterjee VK, Peeters RP, Meima ME, Visser WE. Insight into molecular determinants of T3 vs. T4 recognition from mutations in thyroid hormone receptor alpha and beta. J.Clin. Endocrinol. Metab. (2019). PMID:30817817; PMCID:PMC6599431
Westwater ML, Vilar-López R, Ziauddeen H, Verdejo-García A, Fletcher PC. Combined effects of age and BMI are related to altered cortical thickness in adolescence and adulthood. Dev Cogn Neurosci. 2019 Dec;40:100728. Epub 2019 Nov 5. PubMed PMID: 31751856; PubMed Central PMCID: PMC6913515.
Wieczorek A, Perani CV, Nixon M, Constancia M, Sandovici I, Zazara DE, Leone G, Zhang MZ, Arck PC, Solano ME. Sex-specific regulation of stress-induced fetal glucocorticoid surge by the mouse placenta. Am J Physiol Endocrinol Metab. 2019 Jul 1;317(1):E109-E120. Epub 2019 Apr 16. PMID:30990748
Wray JR, Davies A, Sefton C, Allen TJ, Adamson A, Chapman P, Lam BYH, Yeo GSH, Coll AP, Harno E, White A. Global transcriptomic analysis of the arcuate nucleus following chronic glucocorticoid treatment. Mol Metab. 2019 Aug;26:5-17. PubMed PMID: 31176677.
Yang Y, van der Klaauw AA, Zhu L, Cacciottolo TM, He Y, Stadler LKJ, Wang C, Xu P, Saito K, Hinton A Jr, Yan X, Keogh JM, Henning E, Banton MC, Hendricks AE, Bochukova EG, Mistry V, Lawler KL, Liao L, Xu J, O’Rahilly S, Tong Q; UK10K Consortium, Inês Barroso, O’Malley BW, Farooqi IS, Xu Y. Steroid receptor coactivator-1 modulates the function of Pomc neurons and energy homeostasis. Nat Commun. 2019 Apr 12;10(1):1718. PMID:30979869; PMCID:PMC6461669
Yeo SH, Kyle V, Blouet C, Jones S, Colledge WH. Mapping neuronal inputs to Kiss1 neurons in the arcuate nucleus of the mouse. PLoS One. 2019 Mar 27;14(3):e0213927. eCollection 2019. PMID:30917148; PMCID:PMC6436706
Ziegler AN, Feng Q, Chidambaram S, Testai JM, Kumari E, Rothbard DE, Constancia M, Sandovici I, Cominski T, Pang K, Gao N, Wood TL, Levison SW. Insulin-like Growth Factor II: An Essential Adult Stem Cell Niche Constituent in Brain and Intestine. Stem Cell Reports. 2019 Apr 9;12(4):816-830. doi: 10.1016/j.stemcr.2019.02.011. PMID: 30905741 PMCID: PMC6450461

2018

Adriaenssens AE, Reimann F, Gribble FM.Distribution and Stimulus Secretion Coupling of En- teroendocrine Cells along the Intestinal Tract. Compr Physiol. 2018 Sep 14;8(4):1603-1638.
Agostini M*, Schoenmakers E*, Beig J, Fairall L, Szatmari I, Rajanayagam O, Muskett FW, Adams C, Marais AD, O’Rahilly S, Semple RK, Nagy L, Majithia A, Schwabe JWR, Blom DJ, Murphy R, Chatterjee K†, Savage DB†. A Pharmacogenetic Approach to the Treatment of Patients With PPARG Mutations. Diabetes (2018) 67: 1086-1092 (*coequal first authors;†joint senior authors). PMID:29622583 PMCID:PMC5967605
Aprile M, Cataldi S, Ambrosio MR, D’Esposito V, Lim K, Dietrich A, Blüher M, Savage DB, Formisano P, Ciccodicola A, Costa V. PPARγΔ5, a Naturally Occurring Dominant-Negative Splice Isoform, Impairs PPARγ Function and Adipocyte Differentiation. Cell Rep. 2018 Nov 6;25 (6):1577-1592.e6. doi: 10.1016/j.celrep.2018.10.035.PMID:30404011
Bally L, Thabit H, Hovorka R. Closed-Loop Insulin for Glycemic Control in Noncritical Care. N Engl J Med. 2018 Nov 15;379(20):1970-1971. doi: 10.1056/NEJMc1811995. No abstract availa- ble. PMID:30428293
Bauzá-Thorbrügge M, Rodríguez-Cuenca S, Vidal-Puig A, Galmés-Pascual BM, Sbert-Roig M, Gianotti M, Lladó I, Proenza AM J. GPER and ERα mediate estradiol enhancement of mitochon- drial function in inflamed adipocytes through a PKA dependent mechanism. Steroid Biochem Mol Biol. 2018 Sep 22. pii: S0960-0760(18)30068-2. PMID:30253224
Beeson JH, Blackmore HL, Carr SK, Dearden L, Duque-Guimarães DE, Kusinski LC, Pantaleão LC, Pinnock AG, Aiken CE, Giussani DA, Fernandez-Twinn DS, Ozanne SE. Maternal exercise intervention in obese pregnancy improves the cardiovascular health of the adult male offspring. Mol Metab. 2018 Oct;16:35-44. PMID: 30293577.PMCID: PMC6157615
Berends LM, Dearden L, Tung YCL, Voshol P, Fernandez-Twinn DS, Ozanne SE. Programming of central and peripheral insulin resistance by low birthweight and postnatal catch-up growth in male mice. Diabetologia. 2018 Oct;61(10):2225-2234. PMID: 30043179PMCID: PMC6133152
Billing LJ, Smith CA, Larraufie P, Goldspink DA, Galvin S, Kay RG, Howe JD, Walker R, Pruna M, Glass L, Pais R, Gribble FM, Reimann F.Co-storage and release of insulin-like peptide-5, glu- cagon-like peptide-1 and peptideYY from murine and human colonic enteroendocrine cells. Mol Metab. 2018 Oct;16:65-75. PMID: 30104166 PMCID: PMC6158034
Boughton CK, Hovorka R. Is an artificial pancreas (closed-loop system) for Type 1 diabetes ef- fective? Diabet Med. 2018 Sep 5. Review. PMID: 30183096
Chase JG, Desaive T, Bohe J, Cnop M, De Block C, Gunst J, Hovorka R, Kalfon P, Krinsley J, Renard E, Preiser JC. Improving glycemic control in critically ill patients: personalized care to mimic the endocrine pancreas. Crit Care. 2018 Aug 2;22(1):182. Review. PMID: 30071851 PMCID: PMC6091026
Church D, Cardoso L, Kay RG, Williams CL, Freudenthal B, Clarke C, Harris J, Moorthy M, Kar- ra E, Gribble FM, Reimann F, Burling K, Williams AJK, Munir A, Jones TH, Führer D, Moeller LC, Cohen M, Khoo B, Halsall D, Semple RK. Assessment and Management of Anti-Insulin Auto- antibodies in Varying Presentations of Insulin Autoimmune Syndrome. J Clin Endocrinol Metab. 2018 Oct 1;103(10):3845-3855. PMID: 30085133 PMCID: PMC6179165
Farrington C, Stewart Z, Hovorka R, Murphy HJ. Women’s Experiences of Day-and-Night Closed-Loop Insulin Delivery During Type 1 Diabetes Pregnancy. Diabetes Sci Technol. 2018 Oct 5:1932296818800065. PMID: 30288999PMCID: PMC6232744
Goldspink DA, Reimann F, Gribble FM. Models and Tools for Studying Enteroendocrine Cells. Endocrinology. 2018 Sep 14. doi: 10.1210/en.2018-00672. PMID:30239642
Harno E, Gali Ramamoorthy T, Coll AP, White A.POMC: The Physiological Power of Hormone Processing. Physiol Rev. 2018 Oct 1;98(4):2381-2430. PMID: 30156493PMCID: PMC6170974
Hendricks AE, Billups SC, Pike HNC, Farooqi IS, Zeggini E, Santorico SA, Barroso I, Dupuis J. ProxECAT: Proxy External Controls Association Test. A new case-control gene region associ- ation test using allele frequencies from public controls. PLoS Genet. 2018 Oct 16;14 (10):e1007591. PMID: 30325923PMCID: PMC6191077
Holt MK, Richards JE, Cook DR, Brierley DI, Williams DL, Reimann F, Gribble FM, Trapp S. Preproglucagon Neurons in the Nucleus of the Solitary Tract are the Main Source of Brain GLP-1, Mediate Stress-Induced Hypophagia, and Limit Unusually Large Intakes of Food. Diabe- tes. 2018 Oct 2. pii: db180729. PMID: 30279161PMCID: PMC6314470
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Kirwan P, Kay RG, Brouwers B, Herranz-Pérez V, Jura M, Larraufie P, Jerber J, Pembroke J, Bartels T, White A, Gribble FM, Reimann F, Farooqi IS, O’Rahilly S, Merkle FT. Quantitative mass spectrometry for human melanocortin peptides in vitro and in vivo suggests prominent roles for β-MSH and desacetyl α-MSH in energy homeostasis. Mol Metab. 2018 Nov;17:82-97. PMID: 30201275 PMCID: PMC6197775
Klonoff DC, Evans ML, Lane W, Kempe HP, Renard E, Hans DeVries J, Graungaard T, Hyseni A, Gondolf T, Battelino T. A randomized, multicentre trial evaluating the efficacy and safety of fast-acting insulin aspart in continuous subcutaneous insulin infusion in adults with type 1 diabe- tes (onset 5). Diabetes Obes Metab. 2018 Dec 9. doi: 10.1111/dom.13610. PMID:30537180
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Lotta LA, Stewart ID, Sharp SJ, Day FR, Burgess S, Luan J, Bowker N, Cai L, Li C, Wittemans LBL, Kerrison ND, Khaw KT, McCarthy MI, O’Rahilly S, Scott RA, Savage DB, Perry JRB, Langenberg C, Wareham NJ. Association of Genetically Enhanced Lipoprotein Lipase-Mediated Lipolysis and Low-Density Lipoprotein Cholesterol-Lowering Alleles With Risk of Coronary Dis- ease and Type 2 Diabetes. JAMA Cardiol. 2018 Oct 1;3(10):957-966. PMID: 30326043PMCID: PMC6217943
Mann JP, Vreugdenhil A, Socha P, Jańczyk W, Baumann U, Rajwal S, Casswall T, Marcus C, van Mourik I, O’Rahilly S, Savage DB, Noble-Jamieson G, Lacaille F, Dabbas M, Dubern B, Kelly DA, Nobili V, Anstee European paediatric non-alcoholic fatty liver disease registry (EU- PNAFLD): Design and rationale. Contemp Clin Trials. 2018 Dec;75:67-71. doi: 10.1016/ j.cct.2018.11.003. Epub 2018 Nov 5. PMID30408605
Martin-Gallausiaux C, Larraufie P, Jarry A, Béguet-Crespel F, Marinelli L, Ledue F, Reimann F, Blottière HM, Lapaque N.Butyrate Produced by Commensal Bacteria Down-Regulates Indola- mine 2,3-Dioxygenase 1 (IDO-1) Expression via a Dual Mechanism in Human Intestinal Epitheli- al Cells. Front Immunol. 2018 Dec 11;9:2838. doi: 10.3389/fimmu.2018.02838. eCollection 2018.PMID:30619249 PMCID: PMC6297836
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Pellegrinelli V, Peirce VJ, Howard L, Virtue S, Türei D, Senzacqua M, Frontini A, Dalley JW, Hor- ton AR, Bidault G, Severi I, Whittle A, Rahmouni K, Saez-Rodriguez J, Cinti S, Davies AM, Vidal- Puig A. Adipocyte-secreted BMP8b mediates adrenergic-induced remodeling of the neuro- vascular network in adipose tissue. Nat Commun. 2018 Nov 26;9(1):4974. doi: 10.1038/s41467- 018-07453-x.PMID:30478315
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Rached MT, Millership SJ, Pedroni SMA, Choudhury AI, Costa ASH, Hardy DG, Glegola JA, Ir- vine EE, Selman C, Woodberry MC, Yadav VK, Khadayate S, Vidal-Puig A, Virtue S, Frezza C, Withers DJ. Deletion of myeloid IRS2 enhances adipose tissue sympathetic nerve function and limits obesity. Mol Metab. 2018 Nov 28. pii: S2212-8778(18)31025-1. doi: 10.1016/ j.molmet.2018.11.010. PMID:30553769
Recino A, Gan SU, Sia KC, Sawyer Y, Trendell J, Kay R, Gribble FM, Reimann F, Foale R, No- taridou M, Holmes N, Lever A, Lee KO, Nathwani A, Cooke A, Calne R, Wallberg M. Immunosuppression overcomes insulin- and vector-specific immune responses that limit effi- cacy of AAV2/8-mediated insulin gene therapy in NOD mice. Gene Ther. 2018 Dec 4. doi: 10.1038/s41434-018-0052-5. PMID:30514969
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Rudenko O, Shang J, Munk A, Ekberg JP, Petersen N, Engelstoft MS, Egerod KL, Hjorth SA, Wu M, Feng Y, Zhou YP, Mokrosinski J, Thams P, Reimann F, Gribble F, Rehfeld JF, Holst JJ, Tree- bak JT, Howard AD, Schwartz TW. The aromatic amino acid sensor GPR142 controls metabolism through balanced regulation of pancreatic and gut hormones. Mol Metab. 2019 Jan;19:49-64. doi: 10.1016/j.molmet.2018.10.012. Epub 2018 Nov 5. PMID:30472415
Senyilmaz-Tiebe D, Pfaff DH, Virtue S, Schwarz KV, Fleming T, Altamura S, Muckenthaler MU, Okun JG, Vidal-Puig A, Nawroth P, Teleman AA. Dietary stearic acid regulates mitochondria in vivo in humans. Nat Commun. 2018 Aug 7;9(1):3129. PMID: 30087348PMCID: PMC6081440
Smith MA, Katsouri L, Virtue S, Choudhury AI, Vidal-Puig A, Ashford MLJ, Withers DJ Calcium Channel CaV2.3 Subunits Regulate Hepatic Glucose Production by Modulating Leptin-Induced Excitation of Arcuate Pro-opiomelanocortin Neurons. Cell Rep. 2018 Oct 9;25(2):278-287.e4. PMID: 30304668 PMCID: PMC6198286
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Arif S, Gibson VB, Nguyen V, Bingley PJ, Todd JA, Guy C, Dunger DB, Dayan CM, Powrie J, Lorenc A, Peakman M. β-cell specific T-lymphocyte response has a distinct inflammatory phenotype in children with Type 1 diabetes compared with adults. Diabet Med. 2017; 34:419-25.
Aycan Z, Cangul H, Muzza M, Bas VN, Fugazzola L, Chatterjee VK, Persani L, Schoenmakers N. Digenic DUOX1 and DUOX2 mutations in cases with congenital hypothyroidism. J Clin Endocrinol Metab. 2017. [Epub ahead of print]
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Pestana D, Teixeira D, Meireles M, Marques C, Norberto S, Sá C, Fernandes VC, Correia-Sá L, Faria A, Guardão L, Guimarães JT, Cooper WN, Sandovici I, Domingues VF, Delerue-Matos C, Monteiro R, Constância M, Calhau C.Adipose tissue dysfunction as a central mechanism leading to dysmetabolic obesity triggered by chronic exposure to p,p’-DDE. Sci Rep. 2017; 7:2738.
Petry CJ, Mooslehner K, Prentice P, Hayes MG, Nodzenski M, Scholtens DM, Hughes IA, Acerini CL, Ong KK, Lowe WL Jr, Dunger DB. Associations between a fetal imprinted gene allele score and late pregnancy maternal glucose concentrations. Diabetes Metab. 2017. [Epub ahead of print]
Pompa A, De Marchis F, Pallotta MT, Benitez-Alfonso Y, Jones A, Schipper K, Moreau K, Žárský V, Di Sansebastiano GP, Bellucci M. Unconventional Transport Routes of Soluble and Membrane Proteins and Their Role in Developmental Biology. Int J Mol Sci. 2017; 18(4).
Psichas A, Tolhurst G, Brighton CA, Gribble FM, Reimann F. Mixed Primary Cultures of Murine Small Intestine Intended for the Study of Gut Hormone Secretion and Live Cell Imaging of Enteroendocrine Cells. J Vis Exp. 2017; 122:55687.
Rocha NM, [14 authors], Barroso I: 16, [10 authors], O’Rahilly SI: 27, [2 authors], Savage DB: 30, Semple RK Human biallelic MFN2 mutations induce mitochondrial dysfunction, upper body adipose hyperplasia, and suppression of leptin expression. eLife. 2017; 6: e23813.
Ruan Y, Thabit H, Leelarathna L, Hartnell S, Willinska ME, Tauschmann M, Dellweg S, Benesch C, Mader JK, Holzer M, Kojzar H, Evans ML, Pieber TR, Arnolds S, Hovorka R; AP@home consortium. Faster insulin action is associated with improved glycemic outcomes during closed-loop insulin delivery and sensor-augmented pump therapy in adults with type 1 diabetes. Diabetes Obes Metab. 2017. [Epub ahead of print]
Sferruzzi-Perri AN, Sandovici I, Constancia M, Fowden AL. Placental phenotype and the insulin-like growth factors: resource allocation to fetal growth. J Physiol. 2017; 595:5057-5093.
Taku N, Gurnell M, Burnet N, Jena R. Time dependence of radiation-induced hypothalamic-pituitary axis dysfunction in adults treated for non-pituitary, intracranial neoplasms. Clin Oncol (R Coll Radiol). 2017;29:34-41.
Teo AE, Garg S, Johnson TI, Zhao W, Zhou J, Gomez-Sanchez CE, Gurnell M, Brown MJ. Physiological and Pathological Roles in Human Adrenal of the Glomeruli-Defining Matrix Protein NPNT (Nephronectin). Hypertension. 2017; 69:1207-1216. Apr 17.
Thabit H, Hartnell S, Allen JM, Lake A, Wilinska ME, Ruan Y, Evans ML, Coll AP, Hovorka R. Closed-loop insulin delivery in inpatients with type 2 diabetes: a randomised, parallel-group trial. R.Lancet Diabetes Endocrinol. 2017; 5:117-124.
Tripolszki K, Farkas K, Sulák A, Szolnoky G, Duga B, Melegh B, Knox RG, Parker VER, Semple RK, Kemény L, Széll M, Nagy N. Atypical neurofibromatosis type 1 with unilateral limb hypertrophy mimicking overgrowth syndrome. Clin Exp Dermatol. 2017. [Epub ahead of print]
Tsoukalas M, Psichas A, Reimann F, Gribble FM, Lobstein A, Urbain A. Pregnane glycosides from Cynanchum menarandrense. Steroids. 2017; 125:27-32.
Tsuchiya Y, Peak-Chew S, Newell C, Miller-Aidoo S, Mangal S, Zhyvoloup A, Baković J, Malanchuk O, Pereira G, Kotiadis V, Szabadkai G, Duchen M, Campbell M, Rodriguez Cuenca S, Vidal-Puig A, James A, Murphy MP, Filonenko V, Skehel M, Gout I. Protein CoAlation: A Redox-Regulated Protein Modification by Coenzyme A in Mammalian Cells. Biochem J. 2017; 474:2489-2508.
van der Klaauw AA, Ziauddeen H, Keogh JM, Henning E, Dachi S, Fletcher PC, Farooqi IS Oxytocin administration suppresses hypothalamic activation in response to visual food cues. Sci Rep. 2017; 7:4266.eo CR, Agrawal M, Hoon S, Shabbir A, Shrivastava MK, Huang S, Khoo CM, Chhay V, Yassin MS, Tai ES, Vidal-Puig A, Toh SA. SGBS cells as a model of human adipocyte browning: A comprehensive comparative study with primary human white subcutaneous adipocytes. Sci Rep. 2017; 7:4031.
van Gucht ALM, Moran C, Meima ME, Visser WE, Chatterjee K, Visser TJ, Peeters RP. Resistance to Thyroid Hormone due to Heterozygous Mutations in Thyroid Hormone Receptor Alpha. Curr Top Dev Biol. 2017; 125:337-355.
Vasudevan P, Powell C, Nicholas AK, Scudamore I, Greening J, Park SM, Schoenmakers N. Intrauterine death following intraamniotic triiodothyronine and thyroxine therapy for fetal goitrous hypothyroidism associated with polyhydramnios and caused by a thyroglobulin mutation. Endocrinol Diabetes Metab Case Rep. 2017; 17-0040.
Wheeler SE, Stacey HM, Nahaei Y, Hale SJ, Hardy AB, Reimann F, Gribble FM, Larraufie P, Gaisano HY, Brubaker PL. The SNARE Protein, Syntaxin1a, Plays an Essential Role in Biphasic Exocytosis of the Incretin Hormone, Glucagon-Like Peptide-1. Diabetes. 2017; 66:2327-2338.
Yeo CR, Agrawal M, Hoon S, Shabbir A, Shrivastava MK, Huang S, Khoo CM, Chhay V, Yassin MS, Tai ES, Vidal-Puig A, Toh SA. SGBS cells as a model of human adipocyte browning: A comprehensive comparative study with primary human white subcutaneous adipocytes. Sci Rep. 2017: 7:4031.

2016

(* Open access publications)

Adriaenssens AE, Svendsen B, Lam BY, Yeo GS, Holst JJ, Reimann F, Gribble FM. Transcriptomic profiling of pancreatic alpha, beta and delta cell populations identifies delta cells as a principal target for ghrelin in mouse islets. Diabetologia 2016;59:2156-65. *
Ahmed RM, Irish M, Henning E, Dermody N, Bartley L, Kiernan MC, Piguet O, Farooqi S, Hodges JR. Assessment of eating behavior disturbance and associated neural networks in frontotemporal dementia. JAMA Neurol. 2016;73:282-90.
Aiken CE, Tarry-Adkins JL, Penfold NC, Dearden L, Ozanne SE. Decreased ovarian reserve, dysregulation of mitochondrial biogenesis, and increased lipid peroxidation in female mouse offspring exposed to an obesogenic maternal diet. FASEB J. 2016;30:1548-56. *
Alfaradhi MZ, Kusinski LC, Fernandez-Twinn DS, Pantaleão LC, Carr SK, Ferland-McCollough D, Yeo GS, Bushell M, Ozanne SE. Maternal obesity in pregnancy developmentally programs adipose tissue inflammation in young, lean male mice offspring. Endocrinology 2016;157:4246-56. *
Allison BJ, Kaandorp JJ, Kane AD, Camm EJ, Lusby C, Cross CM, Nevin-Dolan R, Thakor AS, Derks JB, Tarry-Adkins JL, Ozanne SE, Giussani DA. Divergence of mechanistic pathways mediating cardiovascular aging and developmental programming of cardiovascular disease. FASEB J. 2016;30:1968-75. *
Anesten F, Holt MK, Schéle E, Pálsdóttir V, Reimann F, Gribble FM, Safari C, Skibicka KP, Trapp S, Jansson JO. Preproglucagon neurons in the hindbrain have IL-6 receptor-α and show Ca2+ influx in response to IL-6. Am J Physiol Regul Integr Comp Physiol. 2016;311:R115-23. *
Baig S, Parvaresh Rizi E, Shabeer M, Chhay V, Mok SF, Loh TP, Magkos F, Vidal-Puig A, Tai ES, Khoo CM, Toh SA. Metabolic gene expression profile in circulating mononuclear cells reflects obesity-associated metabolic inflexibility. Nutr Metab (Lond). 2016;13:74. *
Boldt K, [54 authors], Group UKRD. An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. Nat Commun. 2016;7:11491. *
Breen DP, Nombela C, Vuono R, Jones PS, Fisher K, Burn DJ, Brooks DJ, Reddy AB, Rowe JB, Barker RA. Hypothalamic volume loss is associated with reduced melatonin output in Parkinson’s disease. Mov Disord. 2016;31:1062-6. *
Burberry A, [15 authors; Merkle FT: 9], Eggan K. Loss-of-function mutations in the C9ORF72 mouse ortholog cause fatal autoimmune disease. Sci Transl Med. 2016;8:347ra93. *
Burke LK, [17 authors], Evans ML, Heisler LK. Sex difference in physical activity, energy expenditure and obesity driven by a subpopulation of hypothalamic POMC neurons. Mol Metab. 2016;5:245-52. *
Carmody D, Ladsaria SS, Buikema RK, Semple RK, Greeley SAW. Successful rhIGF1 treatment for over 5 years in a patient with severe insulin resistance due to homozygous insulin receptor mutation. Diabet Med. 2016;33:e8-12. *
Castillo SD, [26 authors; Semple RK: 23], Vanhaesebroeck B. Somatic activating mutations in Pik3ca cause sporadic venous malformations in mice and humans. Sci Transl Med. 2016;8:332ra43.
Challis BG, Kandasamy N, Powlson AS, Koulouri O, Annamalai AK, Happerfield L, Marker AJ, Arends MJ, Nik-Zainal S, Gurnell M. Familial adrenocortical carcinoma in association with Lynch syndrome. J Clin Endocrinol Metab. 2016;101:2269-72. *
Challis BG, Lim CT, Cluroe A, Cameron E, O’Rahilly S. The McKittrick-Wheelock syndrome: a rare cause of curable diabetes. Endocrinol Diabetes Metab Case Rep. 2016;160013. *
Collet TH, van der Klaauw AA, Henning E, Keogh JM, Suddaby D, Dachi SV, Dunbar S, Kelway S, Dickson SL, Farooqi IS, Schmid SM. The sleep/wake cycle is directly modulated by changes in energy balance. Sleep 2016;39:1691-700. *
Correia-Melo C, [26 authors; Vidal-Puig A: 19], Passos JF. Mitochondria are required for pro-ageing features of the senescent phenotype. EMBO J. 2016;35:724-42.*
Dalgaard K, [28 authors; Yeo GS: 19, O’Rahilly S: 20, Coll AP: 27], Pospisilik JA. Trim28 haploinsufficiency triggers bi-stable epigenetic obesity. Cell 2016;164:353-64. *
Demir T, Onay H, Savage DB, Temeloglu E, Uzum AK, Kadioglu P, Altay C, Ozen S, Demir L, Cavdar U, Akinci B. Familial partial lipodystrophy linked to a novel peroxisome proliferator activator receptor -γ (PPARG) mutation, H449L: a comparison of people with this mutation and those with classic codon 482 Lamin A/C (LMNA) mutations. Diabet Med. 2016;33:1445-50.
Dennedy MC, Annamalai AK, Prankerd Smith O, Freeman N, Vengopal K, Graggaber J, Koulouri O, Powlson AS, Shaw A, Halsall DJ, Gurnell M. Low DHEAS: a sensitive and specific test for detection of subclinical hypercortisolism in adrenal incidentalomas. J Clin Endocrinol Metab. 2016;jc20162718.
Diederen KM, Spencer T, Vestergaard MD, Fletcher PC, Schultz W. Adaptive prediction error coding in the human midbrain and striatum facilitates behavioural adaptation and learning efficiency. Neuron. 2016;90:1127-38. doi: *
Duque-Guimarães DE, de Almeida-Faria J, Ong TP, Ozanne SE. Pulsed SILAC as a approach for miRNA targets identification in cell culture. Methods Mol Biol. 2017;1546:149-59.
Dusaulcy R, Handgraaf S, Heddad-Masson M, Visentin F, Vesin C, Reimann F, Gribble F, Philippe J, Gosmain Y. α-cell dysfunctions and molecular alterations in male insulinopenic diabetic mice are not completely corrected by insulin. Endocrinology 2016;157:536-47.
Edgar RS, Stangherlin A, Nagy AD, Nicoll MP, Efstathiou S, O’Neill JS, Reddy AB. Cell autonomous regulation of herpes and influenza virus infection by the circadian clock. Proc Natl Acad Sci USA. 2016;113:10085-90. *
Ekberg JH, [14 authors; Gribble FM: 10, Reiman F: 11], Schwartz TW. GPR119, a major enteroendocrine sensor of dietary triglyceride metabolites coacting in synergy With FFA1 (GPR40). Endocrinology 2016;157:4561-9.
Farrington C, Allen J, Tauschmann M, Randell T, Trevelyan N, Hovorka R. Factors affecting recruitment of participants for studies of diabetes technology in newly diagnosed youth with type 1 diabetes: a qualitative focus group study with parents and children. Diabetes Technol Ther. 2016;18:568-73. *
Flint TR, Janowitz T, Connell CM, Roberts EW, Denton AE, Coll AP, Jodrell DI, Fearon DT. Tumor-induced IL-6 reprograms host metabolism to suppress anti-tumor immunity. Cell Metab. 2016;24:672-84. *
Fuchsberger C, [301 authors; O’Rahilly SP: 208], McCarthy MI. The genetic architecture of type 2 diabetes. Nature 2016;536:41-7. *
Gathercole LL, [13 authors; Semple RK: 11], Geberhiwot T. Advanced non-alcoholic fatty liver disease and adipose tissue fibrosis in patients with Alström syndrome. Liver Int. 2016;36:1704-12.
Giraud K, Pontin M, Sharples LD, Fletcher P, Dalgleish T, Eden A, Jenkins DP, Vuylsteke A. Use of a structured mirrors intervention does not reduce delirium incidence but may improve factual memory encoding in cardiac surgical ICU patients aged over 70 years: a pilot time-cluster randomized controlled trial. Front Aging Neurosci. 2016;8:228.
Gripp KW, Baker L, Kandula V, Conard K, Scavina M, Napoli JA, Griffin GC, Thacker M, Knox RG, Clark GR, Parker VER, Semple R, Mirzaa G, Keppler-Noreuil KM. Nephroblastomatosis or Wilms tumor in a fourth patient with a somatic PIK3CA mutation. Am J Med Genet A. 2016;170:2559-69.
Groeneveld MP, Brierley GV, Rocha NM, Siddle K, Semple RK. Acute knockdown of the insulin receptor or its substrates Irs1 and 2 in 3T3-L1 adipocytes suppresses adiponectin production. Sci Rep. 2016 Feb 18;6:21105. *
Hall Z, Bond NJ, Ashmore T, Sanders F, Ament Z, Wang X, Murray AJ, Bellafante E, Virtue S, Vidal-Puig A, Allison M, Davies SE, Koulman A, Vacca M, Griffin JL. Lipid zonation and phospholipid remodeling in nonalcoholic fatty liver disease. Hepatology 2016;epub ahead of print.
Heppolette CA, Chen JH, Carr SK, Palmer DB, Ozanne SE. The effects of aging and maternal protein restriction during lactation on thymic involution and peripheral immunosenescence in adult mice. Oncotarget 2016;7:6398-409. *
Holland ML, Lowe R, Caton PW, Gemma C, Carbajosa G, Danson AF, Carpenter AA, Loche E, Ozanne SE, Rakyan VK. Early-life nutrition modulates the epigenetic state of specific rDNA genetic variants in mice. Science 2016;353:495-8.
Hollands GJ, Marteau TM, Fletcher PC. Non-conscious processes in changing health-related behaviour: a conceptual analysis and framework. Health Psychol Rev. 2016;10:381-394. *
Huang-Doran I, [18 authors], Savage DB, Murphy R, O’Rahilly S, Barroso I, Semple RK. Insulin resistance uncoupled from dyslipidemia due to C-terminal PIK3R1 mutations. JCI Insight. 2016;1:e88766. *
Inman M, Daneman D, Curtis J, Sochett E, Elia Y, Dunger DB, Deanfield J, Mahmud FH. Assessing social determinants of health in a pediatric diabetes clinical research trial: Are recruited subjects representative of the larger clinical population? Diabetes Res Clin Pract. 2016;113:41-3.
Joustra SD, Heinen CA, Schoenmakers N, Bonomi M, Ballieux BEPB, Turgeon MO, Bernard DJ, Fliers E, van Trotsenburg ASP, Losekoot M, Persani L, Wit JM, Biermasz NR, Pereira AM, Oostdijk W, Group ICC. IGSF1 deficiency: lessons from an extensive case series and recommendations for clinical management. J Clin Endocrinol Metab. 2016;101:1627-36. *
Joustra SD, Schoenmakers N, [26 authors; Chatterjee K: 22], van Trotsenburg AS. The IGSF1 deficiency syndrome: characteristics of male and female patients. J Clin Endocrinol Metab. 2013;98:4942-52.
Kandasamy N, Garfinkel SN, Page L, Hardy B, Critchley HD, Gurnell M, Coates JM. Interoceptive ability predicts survival on a London trading floor. Sci Rep. 2016;6:32986. *
Kilpeläinen TO, [175 authors; Savage DB: 99], Loos RJ. Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels. Nat Commun. 2016;7:10494. *
Kim HS, [15 authors; Yeo GS: 9], Lee MG. A coding variant in FTO confers susceptibility to thiopurine-induced leukopenia in East Asian patients with IBD. Gut 2016;pii:gutjnl-2016-311921.
Koulouri O, Hoole AC, English P, Allinson K, Antoun N, Cheow H, Burnet NG, Donnelly N, Mannion RJ, Gurnell M. Localisation of an occult thyrotropinoma with (11)C-methionine PET-CT before and after somatostatin analogue therapy. Lancet Diabetes Endocrinol. 2016;4:1050.
Koulouri O, [28 authors], Gurnell M. Successful treatment of residual pituitary adenoma in persistent acromegaly following localisation by 11C-methionine PET co-registered with MRI. Eur J Endocrinol. 2016;175:485-98.
Koulouri O, Nicholas AK, Schoenmakers E, Mokrosinski J, Lane F, Cole T, Kirk J, Farooqi IS, Chatterjee VK, Gurnell M, Schoenmakers N. A novel thyrotropin-releasing hormone receptor missense mutation (P81R) in central congenital hypothyroidism. J Clin Endocrinol Metab. 2016;101:847-51. *
Kuhre RE, Wewer Albrechtsen NJ, Deacon CF, Balk-Møller E, Rehfeld JF, Reimann F, Gribble FM, Holst JJ. Peptide production and secretion in GLUTag, NCI-H716, and STC-1 cells: a comparison to native L-cells. J Mol Endocrinol. 2016;56:201-11.
Langeveld M, Tan CY, Soeters MR, Virtue S, Ambler GK, Watson LP, Murgatroyd PR, Chatterjee VK, Vidal-Puig A. Mild cold effects on hunger, food intake, satiety and skin temperature in humans. Endocr Connect. 2016;5:65-73. *
Leelarathna L, Thabit H, Hartnell S, Willinska ME, Dellweg S, Benesch C, Mader JK, Holzer M, Kojzar H, Evans ML, Arnolds S, Pieber TR, Hovorka R, AP@home Consortium. Rapid benefits of structured optimization and sensor-augmented insulin pump therapy in adults with type 1 diabetes. J Diabetes Sci Technol. 2016;pii:1932296816654715.
Lie S, Morrison JL, Williams-Wyss O, Suter CM, Humphreys DT, Ozanne SE, Zhang S, MacLaughlin SM, Kleemann DO, Walker SK, Roberts CT, McMillen IC. Impact of maternal undernutrition around the time of conception on factors regulating hepatic lipid metabolism and microRNAs in singleton and twin fetuses. Am J Physiol Endocrinol Metab. 2016;310:E148-59. *
Lotta LA, [26 authors; O’Rahilly S: 25], Langenberg C. Genetic predisposition to an impaired metabolism of the branched-chain amino acids and risk of type 2 diabetes: a mendelian randomisation analysis. PLoS Med. 2016;13:e1002179. *
Lotta LA, [39 authors; O’Rahilly S: 35], Wareham NJ. Association between low-density lipoprotein cholesterol-lowering genetic variants and risk of type 2 diabetes: a meta-analysis. JAMA 2016;316:1383-91.
Lu L, Koulman A, Petry CJ, Jenkins B, Matthews L, Hughes IA, Acerini CL, Ong KK, Dunger DB. An unbiased lipidomics approach identifies early second trimester lipids predictive of maternal glycemic traits and gestational diabetes mellitus. Diabetes Care 2016;39:2232-9. *
Maahs DM, [22 authors; Hovorka R: 11], Lum JW. Outcome Measures for Artificial Pancreas Clinical Trials: A Consensus Report. Diabetes Care 2016;39:1175-9.
Majithia AR, [24 authors, O’Rahilly S: 19], Altshuler D. Prospective functional classification of all possible missense variants in PPARG. Nat Genet. 2016;48:1570-5. *
Manning KE, McAllister CJ, Ring HA, Finer N, Kelly CL, Sylvester KP, Fletcher PC, Morrell NW, Garnett MR, Manford MR, Holland AJ. Novel insights into maladaptive behaviours in Prader-Willi syndrome: serendipitous findings from an open trial of vagus nerve stimulation. J Intellect Disabil Res. 2016;60:149-55. *
Marelli F, Carra S, Agostini M, Cotelli F, Peeters R, Chatterjee K, Persani L. Patterns of thyroid hormone receptor expression in zebrafish and generation of a novel model of resistance to thyroid hormone action. Mol Cell Endocrinol. 2016;424:102-17.
Martin-Gronert MS, Fernandez-Twinn DS, Bushell M, Siddle K, Ozanne SE. Cell-autonomous programming of rat adipose tissue insulin signalling proteins by maternal nutrition. Diabetologia 2016;59:1266-75. *
Martin-Gronert MS, Stocker CJ, Wargent ET, Cripps RL, Garfield AS, Jovanovic Z, D’Agostino G, Yeo GS, Cawthorne MA, Arch JR, Heisler LK, Ozanne SE. 5-HT2A and 5-HT2C receptors as hypothalamic targets of developmental programming in male rats. Dis Model Mech. 2016;9:401-12.*
Martínez R, Kapravelou G, Porres JM, Melesio AM, Heras L, Cantarero S, Gribble FM, Parker H, Aranda P, López-Jurado M. Medicago sativa L, a functional food to relieve hypertension and metabolic disorders in a spontaneously hypertensive rat model. Journal of Functional Foods 2016;26:470-84.
Medic N, Ziauddeen H, Ersche KD, Farooqi IS, Bullmore ET, Nathan PJ, Ronan L, Fletcher PC. Increased body mass index is associated with specific regional alterations in brain structure. Int J Obes (Lond). 2016;40:1177-82. *
Medic N, Ziauddeen H, Forwood SE, Davies KM, Ahern AL, Jebb SA, Marteau TM, Fletcher PC. The presence of real food usurps hypothetical health value judgment in overweight people. 2016;3.pii: ENEURO.0025-16.2016. *
Meek CL, Lewis HB, Vergese B, Park A, Reimann F, Gribble F. The effect of encapsulated glutamine on gut peptide secretion in human volunteers. Peptides 2016;77:38-46. *
Morton NM, [31 authors; Vidal-Puig A: 29], Horvat S. Genetic identification of thiosulfate sulfurtransferase as an adipocyte-expressed antidiabetic target in mice selected for leanness. Nat Med. 2016;22:771-9.
Moss CE, Glass LL, Diakogiannaki E, Pais R, Lenaghan C, Smith DM, Wedin M, Bohlooly-Y M, Gribble FM, Reimann F. Lipid derivatives activate GPR119 and trigger GLP-1 secretion in primary murine L-cells. Peptides 2016 Mar;77:16-20. *
Musial B, Fernandez-Twinn DS, Vaughan OR, Ozanne SE, Voshol P, Sferruzzi-Perri AN, Fowden AL. Proximity to delivery alters insulin sensitivity and glucose metabolism in pregnant mice. Diabetes 2016;65:851-60. *
Neupane S, Peverall R, Richmond G, Blaikie TP, Taylor D, Hancock G, Evans ML. Exhaled breath isoprene rises during hypoglycemia in type 1 diabetes. Diabetes Care 2016;39:e97-8.
Nicholas AK, [33 authors], Chatterjee VK, Anderson CA, Schoenmakers N. Comprehensive screening of eight known causative genes in congenital hypothyroidism with gland-in-situ. J Clin Endocrinol Metab. 2016;101:4521-31. *
Nicholas AK, Jaleel S, Lyons G, Schoenmakers E, Dattani MT, Crowne E, Bernhard B, Kirk J, Roche EF, Chatterjee VK, Schoenmakers N. Molecular spectrum of TSHβ subunit gene defects in central hypothyroidism in the UK and Ireland. Clin Endocrinol (Oxf). 2016; Epub ahead of print.
Novoselova TV, Larder R, Rimmington D, Lelliott C, Wynn EH, Gorrigan RJ, Tate PH, Guasti L; Sanger Mouse Genetics Project, O’Rahilly S, Clark AJ, Logan DW, Coll AP, Chan LF. Loss of Mrap2 is associated with Sim1 deficiency and increased circulating cholesterol. J Endocrinol. 2016;230:13-26. *
Overduin J, Collet TH, Medic N, Henning E, Keogh JM, Forsyth F, Stephenson C, Kanning MW, Ruijschop RM, Farooqi IS, van der Klaauw AA. Failure of sucrose replacement with the non-nutritive sweetener erythritol to alter GLP-1 or PYY release or test meal size in lean or obese people. Appetite 2016;107:596-603. *
Pais R, Gribble FM, Reimann F. Signalling pathways involved in the detection of peptones by murine small intestinal enteroendocrine L-cells. Peptides 2016;77:9-15. *
Pais R, Rievaj J, Larraufie P, Gribble F, Reimann F. Angiotensin II type 1 receptor-dependent GLP-1 and PYY secretion in mice and humans. Endocrinology 2016;157:3821-3831. *
Pais R, Rievaj J, Meek C, De Costa G, Jayamaha S, Alexander RT, Reimann F, Gribble F. Role of enteroendocrine L-cells in arginine vasopressin-mediated inhibition of colonic anion secretion. J Physiol. 2016;594:4865-78. *
Parvaresh Rizi E, Baig S, Shabeer M, Teo Y, Mok SF, Loh TP, Magkos F, Virtue S, Vidal-Puig A, Tai ES, Khoo CM, Toh SA. Meal rich in carbohydrate, but not protein or fat, reveals adverse immunometabolic responses associated with obesity. Nutr J. 2016;15:100. *
Pauliina Markkula S, Lyons D, Yueh CY, Riches C, Hurst P, Fielding B, Heisler LK, Evans ML. Intracerebroventricular catalase reduces hepatic insulin sensitivity and increases responses to hypoglycemia in rats. Endocrinology 2016;157:4669-76. *
Petry CJ, Sanz Marcos N, Pimentel G, Hayes MG, Nodzenski M, Scholtens DM, Hughes I A, Acerini CL, Ong KK, Lowe WL, Dunger DB. Associations between fetal imprinted genes and maternal blood pressure in pregnancy. Hypertension 2016;68:1459-66.
Powlson AS, Challis BG, Halsall DJ, Schoenmakers E, Gurnell M. Nephrogenic syndrome of inappropriate antidiuresis secondary to an activating mutation in the arginine vasopressin receptor AVPR2. Clin Endocrinol (Oxf). 2016;85:306-12.
Pozzilli P, Battelino T, Danne T, Hovorka R, Jarosz-Chobot P, Renard E. Continuous subcutaneous insulin infusion in diabetes: patient populations, safety, efficacy, and pharmacoeconomics. Diabetes Metab Res Rev. 2016;32:21-39. *
Psichas A, Glass LL, Sharp SJ, Reimann F, Gribble FM. Galanin inhibits GLP-1 and GIP secretion via the GAL1 receptor in enteroendocrine L and K cells. Br J Pharmacol. 2016;173:888-98. *
Raffan E, [19 authors], Yeo GS, O’Rahilly S. A deletion in the canine POMC Gene is associated with weight and appetite in obesity-prone Labrador Retriever dogs. Cell Metab. 2016;23:893-900. *
Rahbari R, Wuster A, Lindsay SJ, Hardwick RJ, Alexandrov LB, Al Turki S, Dominiczak A, Morris A, Porteous D, Smith B, Stratton MR, UK10K Consortium, Hurles ME. Timing, rates and spectra of human germline mutation. Nat Genet. 2016;48:126-33. *
Rey G, Valekunja UK, Feeney KA, Wulund L, Milev NB, Stangherlin A, Ansel-Bollepalli L, Velagapudi V, O’Neill JS, Reddy AB. The pentose phosphate pathway regulates the circadian clock. Cell Metab. 2016;24:462-73. *
Richards P, Pais R, Habib AM, Brighton CA, Yeo GS, Reimann F, Gribble FM. High fat diet impairs the function of glucagon-like peptide-1 producing L-cells. Peptides 2016;77:21-7. *
Rodriguez-Cuenca S, Whyte L, Hagen R, Vidal-Puig A, Fuller M. Stearoyl-CoA Desaturase 1 is a key determinant of membrane lipid composition in 3T3-L1 adipocytes. PLoS One 2016;11:e0162047. *
Ronan L, Alexander-Bloch AF, Wagstyl K, Farooqi S, Brayne C, Tyler LK; Cam-CAN, Fletcher PC. Obesity associated with increased brain age from midlife. Neurobiol Aging. 2016;47:63-70. *
Rowe ER, Mimmack ML, Barbosa AD, Haider A, Isaac I, Ouberai MM, Thiam AR, Patel S, Saudek V, Siniossoglou S, Savage DB. Conserved amphipathic helices mediate lipid droplet targeting of perilipins 1-3. J Biol Chem. 2016;291:6664-78. *
Ruan Y, [12 authors], Hovorka R, AP@home Consortium. Variability of insulin requirements over 12 weeks of closed-loop insulin delivery in adults with type 1 diabetes. Diabetes Care 2016;39:830-2.
Sandovici I, Hammerle CM, Cooper WN, Smith NH, Tarry-Adkins JL, Dunmore BJ, Bauer J, Andrews SR, Yeo GS, Ozanne SE, Constância M. Ageing is associated with molecular signatures of inflammation and type 2 diabetes in rat pancreatic islets. Diabetologia 2016;59:502-11. *
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