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Research

Wellcome-MRC Institute of Metabolic Science

Metabolic Research Laboratories

Publications

Primary Research Publications

2017   |   2016   |   Older

2020

  1. Alligier M, Barrès R, Blaak EE, Boirie Y, Bouwman J, Brunault P, Campbell K, Clément K, Farooqi IS, Farpour-Lambert NJ, Frühbeck G, Goossens GH, Hager J, Halford JCG, Hauner H, Jacobi D, Julia C, Langin D, Natali A, Neovius M, Oppert JM, Pagotto U, Palmeira AL, Roche H, Rydén M, Scheen AJ, Simon C, Sorensen TIA,Tappy L, Yki-Järvinen H, Ziegler O, Laville M. OBEDIS Core Variables roject: European Expert Guidelines on a Minimal Core Set of Variables to Include in Randomized, Controlled Clinical Trials of Obesity Interventions. Obes Facts. 2020 Jan 13:1-28. Epub ahead of print. PubMed PMID: 31945762. PMCID: PMC7098277.
  2. Anstee QM, Darlay R, Cockell S, Meroni M, Govaere O, Tiniakos D, Burt AD, Bedossa P, Palmer J, Liu YL, Aithal GP, Allison M, Yki-Järvinen H, Vacca M, Dufour JF, Invernizzi P, Prati D, Ekstedt M, Kechagias S, Francque S, Petta S, Bugianesi E, Clement K, Ratziu V, Schattenberg JM, Valenti L, Day CP, Cordell HJ, Daly AK; EPoS Consortium Investigators. Genome-wide Association Study of Non-Alcoholic Fatty Liver and Steatohepatitis in a Histologically-Characterised Cohort. Journal of Hepatology. 2020 Apr 13:S0168-8278(20)30213-0. PMID: 32298765.
  3. Araiz C, Yan A, Bettedi L, Samuelson I, Virtue S, McGavigan AK, Dani C, Vidal-Puig A, Foukas LC. Publisher Correction: Enhanced β-Adrenergic Signalling Underlies an Age-Dependent Beneficial Metabolic Effect of PI3K p110α Inactivation in Adipose Tissue. Nat Commun. 2020 Feb 21;11(1):1078. PMID: 32081871.
  4. Ast J, Arvaniti A, Fine NHF, Nasteska D, Ashford FB, Stamataki Z, Koszegi Z, Bacon A, Jones BJ, Lucey MA, Sasaki S, Brierley DI, Hastoy B, Tomas A, D’Agostino G, Reimann F, Lynn FC, Reissaus CA, Linnemann AK, D’Este E, Calebiro D, Trapp S, Johnsson K, Podewin T, Broichha- gen J, Hodson DJ. Author Correction: Super-resolution microscopy compatible fluorescent probes reveal endogenous glucagon-like peptide-1 receptor distribution and dynamics. Nat Commun. 2020 Oct 9;11(1):5160. PMID: 33037231.
  5. Azzu V, Vacca M, Virtue S, Allison M, Vidal-Puig A. Adipose tissue-liver cross talk in the control of whole-body metabolism: implications in non-alcoholic fatty liver disease. Gastroenterology. 2020 Feb 12. pii: S0016-5085(20)30224-9. Epub ahead of print. PMID: 32061598.
  6. Baig S, Shabeer M, Parvaresh Rizi E, Agarwal M, Lee MH, Ooi DSQ, Chia C, Aung N, Ng G, Teo Y, Chhay V, Magkos F, Vidal-Puig A, Seet RCS, Toh SA. Heredity of type 2 diabetes confers increased susceptibility to oxidative stress and inflammation. BMJ Open Diabetes Res Care. 2020 Jan;8(1). PMID: 32049633. PMCID: PMC7039582.
  7. Banholzer N, Herzig D, Piazza C, Álvarez-Martínez M, Nakas CT, Kosinski C, Feuerriegel S, Hovorka R, Bally L. Effect of nutrition on postprandial glucose control in hospitalized patients with type 2 diabetes receiving fully automated closed-loop insulin therapy. Diabetes Obes Metab. 2020 Sep 4. PMID: 32885596.
  8. Bashari WA, Senanayake R, Koulouri O, Gillett D, MacFarlane J, Powlson AS, FernandezPombo A, Bano G, Martin AJ, Scoffings D, Cheow H, Mendichovszky I, Tysome J, Donnelly N, Santarius T, Kolias A, Mannion R, Gurnell M. PET-guided Repeat Transsphenoidal Surgery for Previously Deemed Unresectable Lateral Disease in Acromegaly. Neurosurgical Focus. 2020 Jun;48(6):E8. PMID: 32480379.
  9. Bernstein RM, O’Connor GK, Vance EA, Affara N, Drammeh S, Dunger DB, Faal A, Ong KK, Sosseh F, Prentice AM, Moore SE. Timing of the Infancy-Childhood Growth Transition in Rural Gambia. Frontiers of Endocrinology (Lausanne). 2020 Mar 24;11:142. PMID: 32265838 PMCID: PMC7105771.
  10. Blackwell AKM, De-Loyde K, Brocklebank LA, Maynard OM, Marteau TM, Hollands GJ, Fletcher PC, Attwood AS, Morris RW, Munafò MR. Tobacco and electronic cigarette cues for smoking and vaping: an online experimental study. BMC Res Notes. 2020 Jan 15;13(1):32. PubMed PMID:31941548; PubMed Central PMCID: PMC6964108.
  11. Blackwell AKM, De-Loyde K, Hollands GJ, Morris RW, Brocklebank LA, Maynard OM, Fletcher PC, Marteau TM, Munafò MR. The Impact on Selection of Non-Alcoholic vs Alcoholic Drink Availability: An Online Experiment. BMC Public Health. 2020 May 6;20(1):526. PMID: 32370760 PMCID: PMC7201696.
  12. Boughton C, Allen JM, Tauschmann M, Hartnell S, Wilinska ME, Musolino G, Acerini CL, Dunger PD, Campbell F, Ghatak A, Randell T, Besser R, Trevelyan N, Elleri D, Northam E, Hood K, Scott E, Lawton J, Roze S, Sibayan J, Kollman C, Cohen N, Todd J, Hovorka R; CLOuD Consortium. Assessing the effect of closed-loop insulin delivery from onset of type 1 diabetes in youth on residual beta-cell function compared to standard insulin therapy (CLOuD study): a randomised parallel study protocol. BMJ Open. 2020 Mar 12;10(3):e033500. PMID: 32169925; PMCID: PMC7069267.
  13. Boughton CK, Hartnell S, Allen JM, Fuchs J, Hovorka R. Training and Support for Hybrid Closed -Loop Therapy. J Diabetes Sci Technol. 2020 Sep 11;1932296820955168. PMID: 32914648.
  14. Boughton CK, Hovorka R. The artificial pancreas. Curr Opin Organ Transplant. 2020 Aug;25 (4):336-342. PMID: 32618719.
  15. Braukmann F, Jordan D, Jenkins B, Koulman A, Miska EA. SID-2 negatively regulates develop- ment likely independent of nutritional dsRNA uptake. RNA Biol. 2020 Oct 12;1-12. PMID: 33044912.
  16. Brierley GV, Webber H,2 Rasijeff E, Grocott S, Siddle K, Semple RK. Anti-Insulin Receptor Anti- bodies Improve Hyperglycemia in a Mouse Model of Human Insulin Receptoropathy. Diabetes 2020;69:1–9. PMID: 32816962.
  17. Burton NO, Riccio C, Dallaire A, Price J, Jenkins B, Koulman A, Miska EA. Cysteine Synthases CYSL-1 and CYSL-2 Mediate C. Elegans Heritable Adaptation to P. Vranovensis Infection. Nature Communications. 2020 Apr 8;11(1):1741. PMID: 32269224 PMCID: PMC7142082.
  18. Calderon G , McRae A, Rievaj J, Davis J, Zandvakili I, Linker-Nord S, Burton D, Roberts G, Reimann F, Gedulin B, Vella A, LaRusso NF, Camilleri M, Gribble FM, Acosta A. Ileo-Colonic Delivery of Conjugated Bile Acids Improves Glucose Homeostasis Via Colonic GLP-1-Producing Enteroendocrine Cells in Human Obesity and Diabetes. EbioMedicine Vol 55, May 2020:102759. PMID: 32344198, PMCID: PMC7186521.
  19. Campbell, J. R., Martchenko, A., Sweeney, M. E., Maalouf, M. F., Psichas, A., Gribble, F. M., Reimann, F., Brubaker PL. Essential role of syntaxin-binding protein-1 in the regulation of glucagon-like peptide-1 secretion. Endocrinology. Volume 161, Issue 5, May 2020. PMID: 32141504.
  20. Campi I, Covelli D, Moran C, Fugazzola L, Cacciatore C, Orlandi F, Gallone G, Chatterjee K, Beck-Peccoz P, Persani L. The Differential Diagnosis of Discrepant Thyroid Function Tests: Insistent Pitfalls and Updated Flow-Chart Based on a Long-Standing Experience. Front Endocrinol (Lausanne) 2020 Jul 7;11:432. PMID: 32733382. PMC7358450.
  21. Chae H, Augustin R, Gatineau E, Mayoux E, Bensellam M, Antoine N, Khattab F, Lai BK, Brusa D, Stierstorfer B, Klein H, Singh B, Ruiz L, Pieper M, Mark M, Herrera PL, Gribble FM, Reimann F, Wojtusciszyn A, Broca C, Rita N, Piemonti L, Gilon P. SGLT2 is not expressed in pancreatic α – and β-cells, and its inhibition does not directly affect glucagon and insulin secretion in rodents and humans. Mol Metab. 2020 Sep 5;42:101071. PMID: 32896668.
  22. Cheng W, Gonzalez I, Pan W, Tsang A H, Adams J, Nkoda E, Gordian D, Khoury B, Roelofs K, Evers S, MacKinnon A, Wu S, Frikke-Schmidt H, Flak J N, Trevaskis J L, Rhodes C J, Fukada S, Seeley R J, Sandoval D A, Olson D P, Blouet C, and Myers, Jr M G. Calcitonin Receptor Neurons in the Mouse Nucleus Tractus Solitarius Control Energy Balance via the non-Aversive Suppression of Feeding. Cell Metab. 2020 Feb 4;31(2):301-312.e5. PubMed PMID: 31955990.
  23. Clarke N, Pechey E, Mantzari E, Blackwell AKM, De-Loyde K, Morris RW, Munafò MR, Marteau TM, Hollands GJ. Impact of Health Warning Labels Communicating the Risk of Cancer on Alcohol Selection: An Online Experimental Study. Addiction. 2020 Apr 8. PMID: 32267588.
  24. Coll AP, Chen M, Taskar P, Rimmington D, Patel S, Tadross JA, Cimino I, Yang M, Welsh P, Virtue S, Goldspink DA, Miedzybrodzka EL, Konopka AR, Esponda RR, Huang JT, Tung YCL, Rodriguez-Cuenca S, Tomaz RA, Harding HP, Melvin A, Yeo GSH, Preiss D, Vidal-Puig A, Vallier L, Nair KS, Wareham NJ, Ron D, Gribble FM, Reimann F, Sattar N, Savage DB, Allan BB, O’Rahilly S. Publisher Correction: GDF15 mediates the effects of metformin on body weight and energy balance. Nature. 2020 Feb;578(7796):E24. PMID: 32051582.
  25. Colombo M, McGurnaghan SJ, Blackbourn LAK, Dalton RN, Dunger D, Bell S, Petrie JR, Green F, MacRury S, McKnight JA, Chalmers J, Collier A, McKeigue PM, Colhoun HM; Scottish Diabetes Research Network (SDRN) Type 1 Bioresource Investigators. Comparison of Serum and Urinary Biomarker Panels With Albumin/Creatinine Ratio in the Prediction of Renal Function Decline in Type 1 Diabetes. Diabetologia. 2020 Apr;63(4):788-798. PMID: 31915892 PMCID: PMC7054370.
  26. Dearden L, Buller S, Furigo IC, Fernandez-Twinn DS, Ozanne SE. Maternal obesity causes fetal hypothalamic insulin resistance and disrupts development of hypothalamic feeding pathways. Mol Metab. 2020 Sep 9;42:101079. PMID: 32919096 PMC7549144.
  27. de Barros Mucci D, Kusinski LC, Wilsmore P, Loche E, Pantaleão LC, Ashmore TJ, Blackmore HL, Fernandez-Twinn DS, Carmo MDGTD, Ozanne SE. Impact of maternal obesity on placental transcriptome and morphology associated with fetal growth restriction in mice. Int J Obes (Lond). 2020 Mar 13. PMID:32203108.
  28. Diederen KMJ, Fletcher PC. Dopamine, Prediction Error and Beyond. Neuroscientist. 2020 Apr 26:1073858420907591. PMID: 32338128.
  29. Fisher BG, Thankamony A, Mendiola J, Petry CJ, Frederiksen H, Andersson AM, Juul A, Ong KK, Dunger DB, Hughes IA, Acerini CL. Maternal Serum Concentrations of Bisphenol A and Propyl Paraben in Early Pregnancy Are Associated With Male Infant Genital Development. Human Reproduction. 2020 Apr 28;35(4):913-928. PMID: 32325494.
  30. Fleseriu M, Buchfelder M, Cetas JS, Fazeli PK, Mallea-Gil SM, Gurnell M, McCormack A, Pineyro MM, Syro LV, Tritos NA, Marcus HJ. Pituitary society guidance: pituitary disease management and patient care recommendations during the COVID-19 pandemic-an international perspective. Pituitary. 2020 Aug;23(4):327-337. PMID: 32556793. PMC7300368.
  31. Fuchs J, Hovorka R. Closed-loop control in insulin pumps for type-1 diabetes mellitus: safety and efficacy. Expert Rev Med Devices. 2020 Jul 3;1-14. PMID: 32569476.
  32. Fuchs J, Hovorka R. COVID-19 and Diabetes: Could Diabetes Technology Research Help Pave the Way for Remote Healthcare? Journal of Diabetes Science and Technology. 2020 May 30:1932296820929714. PMID: 32475169.
  33. Furse S, Fernandez-Twinn DS, Jenkins B, Meek CL, Williams HEL, Smith GCS, CharnockJones DS, Ozanne SE, Koulman A. A high-throughput platform for detailed lipidomic analysis of a range of mouse and human tissues. Anal Bioanal Chem. 2020 Mar 7. Epub ahead of print. PMID: 32144454.
  34. Furse S, Koulman A. Lipid extraction from dried blood spots and dried milk spots for untargeted high throughput lipidomics. Mol Omics. 2020 Sep 18. PMID: 32945330.
  35. Furse S, Watkins AJ, Koulman A. Extraction of Lipids from Liquid Biological Samples for HighThroughput Lipidomics. Molecules. 2020 Jul 13;25(14):E3192. PMID: 32668693.
  36. Galindo RJ, Umpierrez GE, Rushakoff RJ, Basu A, Lohnes S, Nichols JH, Spanakis EK, Espino- za J, Palermo NE, Awadjie DG, Bak L, Buckingham B, Cook CB, Freckmann G, Heinemann L, Hovorka R, Mathioudakis N, Newman T, O’Neal DN, Rickert M, Sacks DB, Seley JJ, Wallia A, Shang T, Zhang JY, Han J, Klonoff DC. Continuous Glucose Monitors and Automated Insulin Dosing Systems in the Hospital Consensus Guideline. J Diabetes Sci Technol. 2020 Sep 28;1932296820954163. PMID: 32985262.
  37. Georgescu T, Lyons D, Doslikova B, Garcia AP, Marston O, Burke LK, Chianese R, Lam BYH, Yeo GSH, Rochford JJ, Garfield AS, Heisler LK. Neurochemical Characterization of Brainstem Pro-Opiomelanocortin Cells. Endocrinology. 2020 Apr 1;161(4). PMID: 32166324.
  38. Gil A, Rueda R, Ozanne SE, van der Beek EM, van Loo-Bouwman C, Schoemaker M, Marinello V, Venema K, Stanton C, Schelkle B, Flourakis M, Edwards CA. Is there evidence for bacterial transfer via the placenta and any role in the colonization of the infant gut? – a systematic review. Crit Rev Microbiol. 2020 Aug 10;1-15. PMID: 32776793.
  39. Giustina A, Barkhoudarian G, Beckers A, Ben-Shlomo A, Biermasz N, Biller B, Boguszewski C, Bolanowski M, Bollerslev J, Bonert V, Bronstein MD, Buchfelder M, Casanueva F, Chanson P, Clemmons D, Fleseriu M, Formenti AM, Freda P, Gadelha M, Geer E, Gurnell M, Heaney AP, Ho KKY, Ioachimescu AG, Lamberts S, Laws E, Losa M, Maffei P, Mamelak A, Mercado M, Molitch M, Mortini P, Pereira AM, Petersenn S, Post K, Puig-Domingo M, Salvatori R, Samson SL, Shimon I, Strasburger C, Swearingen B, Trainer P, Vance ML, Wass J, Wierman ME, Yuen KCJ, Zatelli MC, Melmed S. Multidisciplinary management of acromegaly: A consensus. Rev Endocr Metab Disord. 2020 Dec;21(4):667-678. PMID: 32914330.
  40. Goh, K.J., Chen, J., Rocha, N. Semple, R.K. Human pluripotent stem cell-based models suggest preadipocyte senescence as a possible cause of metabolic complications of Werner and Bloom Syndromes. Scientific Reports. Vol 10, Article number: 7490 (2020). PMID: 32367056, PMC7198505.
  41. Goldspink DA, Lu VB, Miedzybrodzka EL, Smith CA, Foreman RE, Billing LJ, Kay RG, *Reimann F, *Gribble FM (2020) Labelling and characterization of human GLP-1 secreting Lcells in primary ileal organoid culture. Cell Reports 2020 Jun 30;31(13):107833. doi: 10.1016/j.celrep.2020.107833. PMID: 32610134
  42. Groeneweg S, van Geest FS, Abacı A, Alcantud A, Ambegaonkar GP, Armour CM, Bakhtiani P, Barca D, Bertini ES, van Beynum IM, Brunetti-Pierri N, Bugiani M, Cappa M, Cappuccio G, Castellotti B, Castiglioni C, Chatterjee K, de Coo IFM, Coutant R, Craiu D, Crock P, DeGoede C, Demir K, Dica A, Dimitri P, Dolcetta-Capuzzo A, Dremmen MHG, Dubey R, Enderli A, Fairchild J, Gallichan J, George B, Gevers EF, Hackenberg A, Halász Z, Heinrich B, Huynh T, Kłosowska A, van der Knaap MS, van der Knoop MM, Konrad D, Koolen DA, Krude H, Lawson-Yuen A, Lebl J, Linder-Lucht M, Lorea CF, Lourenço CM, Lunsing RJ, Lyons G, Malikova J, Mancilla EE, McGowan A, Mericq V, Lora FM, Moran C, Müller KE, Oliver-Petit I, Paone L, Paul PG, Polak M, Porta F, Poswar FO, Reinauer C, Rozenkova K, Menevse TS, Simm P, Simon A, Singh Y, Spada M, van der Spek J, Stals MAM, Stoupa A, Subramanian GM, Tonduti D, Turan S, den Uil CA, Vanderniet J, van der Walt A, Wémeau JL, Wierzba J, de Wit MY, Wolf NI, Wurm M, Zibordi F, Zung A, Zwaveling-Soonawala N, Visser WE. Disease characteristics of MCT8 deficiency: an international, retrospective, multicentre cohort study. Lancet Diabetes Endocrinol. 2020 Jul;8 (7):594-605. PMID: 32559475.
  43. Haarsma J, Fletcher PC, Griffin JD, Taverne HJ, Ziauddeen H, Spencer TJ, Miller C, Katthagen T, Goodyer I, Diederen KMJ, Murray GK. Correction: Precision weighting of cortical unsigned prediction error signals benefits learning, is mediated by dopamine, and is impaired in psycho- sis. Mol Psychiatry. 2020 Oct 14. PMID: 33057170.
  44. Hall Z, Chiarugi D, Charidemou E, Leslie J, Scott E, Pelligrinet L, Allison M, Mocciaro G, Anstee QM, Evan GI, Hoare M, Vidal-Puig A, Oakley F, Vacca M, Griffin JL. Lipid Remodelling in Hepatocyte Proliferation and Hepatocellular Carcinoma. Hepatology. 2020 May 27. PMID: 32460431.
  45. Hammerle CM, Sandovici I, Brierley GV, Smith NM, Zimmer WE, Zvetkova I, Prosser HM, Sekita Y, Lam BYH, Ma M, Cooper WN, Vidal-Puig A, Ozanne SE, Medina-Gómez G, Constância M. Mesenchyme-derived IGF2 is a major paracrine regulator of pancreatic growth and function. PLoS Genet. 2020 Oct 15;16(10):e1009069. PMID: 33057429.
  46. Herzig D, Studer D, Nakas CT, Kuenzli C, Stauffer TP, Hovorka R, Bally L. Effect of fully auto- mated closed-loop insulin delivery using faster aspart versus standard aspart on gluco- regulatory hormones in type 2 diabetes. Diabetes Obes Metab. 2020 Sep 9. PMID: 32902125.
  47. Holt MK, Cook DR, Brierley DI, Richards JE, Reimann F, Gourine AV, Marina N, Trapp S. PPG Neurons in the Nucleus of the Solitary Tract Modulate Heart Rate but Do Not Mediate GLP-1 Receptor Agonist-Induced Tachycardia in Mice. Molecular Metabolism. 2020 May 21:101024. PMID: 32446875.
  48. Jenkins B, Ronis M, Koulman A. LC-MS Lipidomics: Exploiting a Simple High-Throughput Method for the Comprehensive Extraction of Lipids in a Ruminant Fat Dose-Response Study. Metabolites. 2020 Jul 17;10(7):296. PMID: 32709069. PMC7407148.
  49. Joustra SD, Roelfsema F, van Trotsenburg ASP, Schneider HJ, Kosilek RP, Kroon HM, Logan JG, Butterfield NC, Zhou X, Toufaily C, Bak B, Turgeon MO, Brûlé E, Steyn FJ, Gurnell M, Koulouri O, Le Tissier P, Fontanaud P, Duncan Bassett JH, Williams GR, Oostdijk W, Wit JM, Pereira AM, Biermasz NR, Bernard DJ, Schoenmakers N. IGSF1 Deficiency Results in Human and Murine Somatotrope Neurosecretory Hyperfunction. J Clin Endocrinol Metab. 2020 Mar 1;105 (3). PubMed PMID: 31650157.
  50. Joustra SD, Roelfsema F, Paul van Trotsenburg AS, Schneider HJ, Kosilek RP, Kroon HM, Logan JG, Butterfield NC, Zhou X, Toufaily C, Bak B, Turgeon MO, Brûlé E, Steyn FJ, Gurnell M, Koulouri O, Le Tissier P, Fontanaud P, Bassett JHD, Williams GR, Oostdijk W, Wit JM, Pereira AM, Biermasz NR, Bernard DJ, Schoenmakers N. Response to Letter to the Editor: IGSF1 Deficiency Results in Human and Murine Somatotrope Neurosecretory Hyperfunction. J Clin Endocrinol Metab. 2020 Mar 24. PMID: 32211768
  51. Joustra SD, Roelfsema F, van Trotsenburg ASP, Schneider HJ, Kosilek RP, Kroon HM, Logan JG, Butterfield NC, Zhou X, Toufaily C, Bak B, Turgeon MO, Brûlé E, Steyn FJ, Gurnell M, Koulouri O, Le Tissier P, Fontanaud P, Bassett JHD, Williams GR, Oostdijk W, Wit JM, Pereira AM, Biermasz NR, Bernard DJ, Schoenmakers N. Response to Letter to the Editor: “IGSF1 Deficiency Results in Human and Murine Somatotrope Neurosecretory Hyperfunction”. Journal of Clinical Endocrinology and Metabolism. 2020 Jun 1;105(6):dgaa147. PMID: 32211768 PMCID: PMC7159029.
  52. Kanakis I, Alameddine M, Scalabrin M, van ‘t Hof RJ, Liloglou T, Ozanne SE, Goljanek-Whysall K, Vasilaki A. Low protein intake during reproduction compromises the recovery of lactationinduced bone loss in female mouse dams without affecting skeletal muscles. FASEB J. 2020 Jul 11. PMID: 32652768.
  53. Kay RG, Foreman RE, Roberts GP, Hardwick R, Reimann F, Gribble FM. Mass Spectrometric Characterisation of the Circulating Peptidome Following Oral Glucose Ingestion in Control and Gastrectomised Patients. Rapid Communications in Mass Spectrometry. 2020 Jun 3:e8849. PMID: 32492232.
  54. Khoo S, Lyons G, McGowan A, Gurnell M, Oddy S, Visser WE, van den Berg S, Halsall D, Taylor K, Chatterjee K, Moran C. Familial dysalbuminaemic hyperthyroxinemia interferes with current free thyroid hormone immunoassay methods. Eur J Endocrinol. 2020 Mar 1. PMID: 32213658.
  55. Khoo S, Lyons G, McGowan A, Gurnell M, Oddy S, Visser WE, van den Berg S, Halsall D, Taylor K, Chatterjee K, Moran C. Familial Dysalbuminaemic Hyperthyroxinaemia Interferes With Current Free Thyroid Hormone Immunoassay Methods. European Journal of Endocrinology. 2020 Jun;182(6):533-538. PMID: 32213658 PMCID: PMC7222281.
  56. Khoo S, Lyons G, Solomon A, Oddy S, Halsall D, Chatterjee K, Moran C. Familial dysalbuminemic hyperthyroxinemia confounding management of coexistent autoimmune thyroid disease. Endocrinol Diabetes Metab Case Rep. 2020 Feb 26;2020. PMID: 32101523.
  57. Kohnke S, Meek CL. Don’t seek, don’t find: the diagnostic challenge of Wernicke’s encephalopathy. Ann Clin Biochem. 2020 Jul13;PMID: 32551830
  58. Kolias A, Tysome J, Donnelly N, Sharma R, Gkrania-Klotsas E, Budohoski K, Karcheva S, Adapa R, Lawes I, Gurnell M, Hutchinson P, Bance M, Axon P, Santarius T, Mannion RJ. A Safe Approach to Surgery for Pituitary and Skull Base Lesions During the COVID-19 Pandemic. Acta Neurochirurgica (Wien). 2020 May 9:1-3. PMID: 32388681 PMCID: PMC7211050.
  59. Krycer JR, Elkington SD, Diaz-Vegas A, Cooke KC, Burchfield JG, Fisher-Wellman KH, Cooney GJ, Fazakerley DJ, James DE. Mitochondrial Oxidants, but Not Respiration, Are Sensitive to Glucose in Adipocytes. Journal of Biological Chemistry. 2020 Jan 3;295(1):99-110. PMID: 31744882 PMCID: PMC6952605.
  60. Kwok A, Zvetkova I, Virtue S, Luijten I, Huang-Doran I, Tomlinson P, Bulger DA, West J, Murfitt S, Griffin J, Alam R, Hart D, Knox R, Voshol P, Vidal-Puig A, Jensen J, O’Rahilly S, Semple RK. Truncation of Pik3r1 Causes Severe Insulin Resistance Uncoupled From Obesity and Dyslipidemia by Increased Energy Expenditure. Molecular Metabolism. 2020 May 18:101020. PMID: 32439336.
  61. Lawler K, Huang-Doran I, Sonoyama T, Collet TH, Keogh JM, Henning E, O’Rahilly S, Bottolo L, Farooqi IS. Leptin-mediated Changes in the Human Metabolome. Journal of Clinical Endocrinology and Metabolism. Volume 105, Issue 8, August 2020. PMID: 32392278.
  62. Leelarathna L, Thabit H, Hovorka R, Evans M. Estimated HbA 1c and glucose management indi- cator (GMI): are they the same? Diabet Med. 2020 Oct 15;e14423. PMID: 33058254.
  63. Lewis JE, Miedzybrodzka EL, Foreman RE, Woodward ORM, Kay RG, Goldspink DA, Gribble FM, Reimann F. Selective stimulation of colonic L cells improves metabolic outcomes in mice. Diabetologia. 2020 Apr 27. PMID: 32342115.
  64. Leelarathna L, Thabit H, Willinska ME, Bally L, Mader JK, Arnolds S, Benesch C, Pieber TR, Shah VN, Carlson AL, Bergenstal RM, Evans ML, Hovorka R; AP@home04 and APCam11 consortia. Duration of Hybrid Closed-Loop Insulin Therapy to Achieve Representative Glycemic Outcomes in Adults With Type 1 Diabetes. Diabetes Care. 2020 Jan 16. pii: dc192041. Epub ahead of print. PubMed PMID: 31949086.
  65. Liang ZS, Cimino I, Yalcin B, Raghupathy N, Vancollie VE, Ibarra-Soria X, Firth HV, Rimmington D, Farooqi IS, Lelliott CJ, Munger SC, O’Rahilly S, Ferguson-Smith AC, Coll, Logan DW. Trappc9 deficiency causes parent-of-origin dependent microcephaly and obesity. Plos Genetics. 2020 Sept 2. PMID: 32877400 PMC7467316.
  66. Lockhart S, O’Rahilly S. When two pandemics meet: Why is obesity associated with increased COVID-19 mortality. Med. 25 June 2020.
  67. Lockhart SM, Saudek V, O’Rahilly S. GDF15: A hormone conveying somatic distress to the brain. Endocrine Reviews. Vol 41 Issue 4 2020 Apr 20. PMID: 32310257. Lockhart SM, O’Rahilly S. The wasting hormone GDF15 frees up fat to fight infection. Nature Metabolism 2019;1:935-936 (news and views).
  68. Lund ML , Sorrentino G, Egerod KL, Kroone C, Mortensen B, Knop FK, Reimann F, Gribble FM, Drucker DJ, de Koning EJP, Schoonjans K, Bäckhed F, Schwartz TW, Petersen N (2020) L-cell differentiation is induced by bile acids through GLP-1 and paracrine serotonin signaling. Diabetes 2020 Apr;69(4):614-623. doi: 10.2337/db19-0764. Epub 2020 Feb 10. PMID: 32041793 PMCID: PMC7224989
  69. MacFarlane J, Bashari WA, Senanayake R, Gillett D, van der Meulen M, Powlson AS, Kolias A, Koulouri O, Gurnell M. Advances in the Imaging of Pituitary Tumors. Endocrinol Metab Clin North Am. 2020 Sep;49(3):357-373. PMID: 32741476.
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  85. Müller TD, Finan B, Bloom SR, D’Alessio D, Drucker DJ, Flatt PR, Fritsche A, Gribble F, Grill HJ, Habener JF, Holst JJ, Langhans W, Meier JJ, Nauck MA, Perez-Tilve D, Pocai A, Reimann F, Sandoval DA, Schwartz TW, Seeley RJ, Stemmer K, Tang-Christensen M, Woods SC, DiMarchi RD, Tschöp MH. Glucagon-like peptide 1 (GLP-1). Mol Metab. 2019 Dec;30:72-130. Epub 2019 Sep 30. Review. PMID: 31767182. PMCID: PMC6812410.

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2018

  1. Adriaenssens AE, Reimann F, Gribble FM.Distribution and Stimulus Secretion Coupling of En- teroendocrine Cells along the Intestinal Tract. Compr Physiol. 2018 Sep 14;8(4):1603-1638.
  2. Aprile M, Cataldi S, Ambrosio MR, D’Esposito V, Lim K, Dietrich A, Blüher M, Savage DB, Formisano P, Ciccodicola A, Costa V. PPARγΔ5, a Naturally Occurring Dominant-Negative Splice Isoform, Impairs PPARγ Function and Adipocyte Differentiation. Cell Rep. 2018 Nov 6;25 (6):1577-1592.e6. doi: 10.1016/j.celrep.2018.10.035.PMID:30404011
  3. Bally L, Thabit H, Hovorka R. Closed-Loop Insulin for Glycemic Control in Noncritical Care. N Engl J Med. 2018 Nov 15;379(20):1970-1971. doi: 10.1056/NEJMc1811995. No abstract availa- ble. PMID:30428293
  4. Bauzá-Thorbrügge M, Rodríguez-Cuenca S, Vidal-Puig A, Galmés-Pascual BM, Sbert-Roig M, Gianotti M, Lladó I, Proenza AM J. GPER and ERα mediate estradiol enhancement of mitochon- drial function in inflamed adipocytes through a PKA dependent mechanism. Steroid Biochem Mol Biol. 2018 Sep 22. pii: S0960-0760(18)30068-2. PMID:30253224
  5. Beeson JH, Blackmore HL, Carr SK, Dearden L, Duque-Guimarães DE, Kusinski LC, Pantaleão LC, Pinnock AG, Aiken CE, Giussani DA, Fernandez-Twinn DS, Ozanne SE. Maternal exercise intervention in obese pregnancy improves the cardiovascular health of the adult male offspring. Mol Metab. 2018 Oct;16:35-44. PMID: 30293577.PMCID: PMC6157615
  6. Berends LM, Dearden L, Tung YCL, Voshol P, Fernandez-Twinn DS, Ozanne SE. Programming of central and peripheral insulin resistance by low birthweight and postnatal catch-up growth in male mice. Diabetologia. 2018 Oct;61(10):2225-2234. PMID: 30043179PMCID: PMC6133152
  7. Billing LJ, Smith CA, Larraufie P, Goldspink DA, Galvin S, Kay RG, Howe JD, Walker R, Pruna M, Glass L, Pais R, Gribble FM, Reimann F.Co-storage and release of insulin-like peptide-5, glu- cagon-like peptide-1 and peptideYY from murine and human colonic enteroendocrine cells. Mol Metab. 2018 Oct;16:65-75. PMID: 30104166 PMCID: PMC6158034
  8. Boughton CK, Hovorka R. Is an artificial pancreas (closed-loop system) for Type 1 diabetes ef- fective? Diabet Med. 2018 Sep 5. Review. PMID: 30183096
  9. Chase JG, Desaive T, Bohe J, Cnop M, De Block C, Gunst J, Hovorka R, Kalfon P, Krinsley J, Renard E, Preiser JC. Improving glycemic control in critically ill patients: personalized care to mimic the endocrine pancreas. Crit Care. 2018 Aug 2;22(1):182. Review. PMID: 30071851 PMCID: PMC6091026
  10. Church D, Cardoso L, Kay RG, Williams CL, Freudenthal B, Clarke C, Harris J, Moorthy M, Kar- ra E, Gribble FM, Reimann F, Burling K, Williams AJK, Munir A, Jones TH, Führer D, Moeller LC, Cohen M, Khoo B, Halsall D, Semple RK. Assessment and Management of Anti-Insulin Auto- antibodies in Varying Presentations of Insulin Autoimmune Syndrome. J Clin Endocrinol Metab. 2018 Oct 1;103(10):3845-3855. PMID: 30085133 PMCID: PMC6179165
  11. Farrington C, Stewart Z, Hovorka R, Murphy HJ. Women’s Experiences of Day-and-Night Closed-Loop Insulin Delivery During Type 1 Diabetes Pregnancy. Diabetes Sci Technol. 2018 Oct 5:1932296818800065. PMID: 30288999PMCID: PMC6232744
  12. Goldspink DA, Reimann F, Gribble FM. Models and Tools for Studying Enteroendocrine Cells. Endocrinology. 2018 Sep 14. doi: 10.1210/en.2018-00672. PMID:30239642
  13. Harno E, Gali Ramamoorthy T, Coll AP, White A.POMC: The Physiological Power of Hormone Processing. Physiol Rev. 2018 Oct 1;98(4):2381-2430. PMID: 30156493PMCID: PMC6170974
  14. Hendricks AE, Billups SC, Pike HNC, Farooqi IS, Zeggini E, Santorico SA, Barroso I, Dupuis J. ProxECAT: Proxy External Controls Association Test. A new case-control gene region associ- ation test using allele frequencies from public controls. PLoS Genet. 2018 Oct 16;14 (10):e1007591. PMID: 30325923PMCID: PMC6191077
  15. Holt MK, Richards JE, Cook DR, Brierley DI, Williams DL, Reimann F, Gribble FM, Trapp S. Preproglucagon Neurons in the Nucleus of the Solitary Tract are the Main Source of Brain GLP-1, Mediate Stress-Induced Hypophagia, and Limit Unusually Large Intakes of Food. Diabe- tes. 2018 Oct 2. pii: db180729. PMID: 30279161PMCID: PMC6314470
  16. Jenkins B, Aoun M, Feillet-Coudray C, Coudray C, Ronis M, Koulman A. The Dietary Total-Fat Content Affects the In Vivo Circulating C15:0 and C17:0 Fatty Acid Levels Independently. Nutri- ents. 2018 Nov 3;10(11). pii: E1646. doi: 10.3390/nu10111646.PMID:30400275
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  53. Tsoukalas M, Psichas A, Reimann F, Gribble FM, Lobstein A, Urbain A. Pregnane glycosides from Cynanchum menarandrense. Steroids. 2017; 125:27-32.
  54. Tsuchiya Y, Peak-Chew S, Newell C, Miller-Aidoo S, Mangal S, Zhyvoloup A, Baković J, Malanchuk O, Pereira G, Kotiadis V, Szabadkai G, Duchen M, Campbell M, Rodriguez Cuenca S, Vidal-Puig A, James A, Murphy MP, Filonenko V, Skehel M, Gout I. Protein CoAlation: A Redox-Regulated Protein Modification by Coenzyme A in Mammalian Cells. Biochem J. 2017; 474:2489-2508.
  55. van der Klaauw AA, Ziauddeen H, Keogh JM, Henning E, Dachi S, Fletcher PC, Farooqi IS Oxytocin administration suppresses hypothalamic activation in response to visual food cues. Sci Rep. 2017; 7:4266.eo CR, Agrawal M, Hoon S, Shabbir A, Shrivastava MK, Huang S, Khoo CM, Chhay V, Yassin MS, Tai ES, Vidal-Puig A, Toh SA. SGBS cells as a model of human adipocyte browning: A comprehensive comparative study with primary human white subcutaneous adipocytes. Sci Rep. 2017; 7:4031.
  56. van Gucht ALM, Moran C, Meima ME, Visser WE, Chatterjee K, Visser TJ, Peeters RP. Resistance to Thyroid Hormone due to Heterozygous Mutations in Thyroid Hormone Receptor Alpha. Curr Top Dev Biol. 2017; 125:337-355.
  57. Vasudevan P, Powell C, Nicholas AK, Scudamore I, Greening J, Park SM, Schoenmakers N. Intrauterine death following intraamniotic triiodothyronine and thyroxine therapy for fetal goitrous hypothyroidism associated with polyhydramnios and caused by a thyroglobulin mutation. Endocrinol Diabetes Metab Case Rep. 2017; 17-0040.
  58. Wheeler SE, Stacey HM, Nahaei Y, Hale SJ, Hardy AB, Reimann F, Gribble FM, Larraufie P, Gaisano HY, Brubaker PL.  The SNARE Protein, Syntaxin1a, Plays an Essential Role in Biphasic Exocytosis of the Incretin Hormone, Glucagon-Like Peptide-1. Diabetes. 2017; 66:2327-2338.
  59. Yeo CR, Agrawal M, Hoon S, Shabbir A, Shrivastava MK, Huang S, Khoo CM, Chhay V, Yassin MS, Tai ES, Vidal-Puig A, Toh SA. SGBS cells as a model of human adipocyte browning: A comprehensive comparative study with primary human white subcutaneous adipocytes. Sci Rep. 2017: 7:4031.

 

2016

(* Open access publications)

  1. Adriaenssens AE, Svendsen B, Lam BY, Yeo GS, Holst JJ, Reimann F, Gribble FM. Transcriptomic profiling of pancreatic alpha, beta and delta cell populations identifies delta cells as a principal target for ghrelin in mouse islets. Diabetologia 2016;59:2156-65. *
  2. Ahmed RM, Irish M, Henning E, Dermody N, Bartley L, Kiernan MC, Piguet O, Farooqi S, Hodges JR. Assessment of eating behavior disturbance and associated neural networks in frontotemporal dementia. JAMA Neurol. 2016;73:282-90.
  3. Aiken CE, Tarry-Adkins JL, Penfold NC, Dearden L, Ozanne SE. Decreased ovarian reserve, dysregulation of mitochondrial biogenesis, and increased lipid peroxidation in female mouse offspring exposed to an obesogenic maternal diet. FASEB J. 2016;30:1548-56. *
  4. Alfaradhi MZ, Kusinski LC, Fernandez-Twinn DS, Pantaleão LC, Carr SK, Ferland-McCollough D, Yeo GS, Bushell M, Ozanne SE. Maternal obesity in pregnancy developmentally programs adipose tissue inflammation in young, lean male mice offspring. Endocrinology 2016;157:4246-56. *
  5. Allison BJ, Kaandorp JJ, Kane AD, Camm EJ, Lusby C, Cross CM, Nevin-Dolan R, Thakor AS, Derks JB, Tarry-Adkins JL, Ozanne SE, Giussani DA. Divergence of mechanistic pathways mediating cardiovascular aging and developmental programming of cardiovascular disease. FASEB J. 2016;30:1968-75. *
  6. Anesten F, Holt MK, Schéle E, Pálsdóttir V, Reimann F, Gribble FM, Safari C, Skibicka KP, Trapp S, Jansson JO. Preproglucagon neurons in the hindbrain have IL-6 receptor-α and show Ca2+ influx in response to IL-6. Am J Physiol Regul Integr Comp Physiol. 2016;311:R115-23. *
  7. Baig S, Parvaresh Rizi E, Shabeer M, Chhay V, Mok SF, Loh TP, Magkos F, Vidal-Puig A, Tai ES, Khoo CM, Toh SA. Metabolic gene expression profile in circulating mononuclear cells reflects obesity-associated metabolic inflexibility. Nutr Metab (Lond). 2016;13:74. *
  8. Boldt K, [54 authors], Group UKRD. An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. Nat Commun. 2016;7:11491. *
  9. Breen DP, Nombela C, Vuono R, Jones PS, Fisher K, Burn DJ, Brooks DJ, Reddy AB, Rowe JB, Barker RA. Hypothalamic volume loss is associated with reduced melatonin output in Parkinson’s disease. Mov Disord. 2016;31:1062-6. *
  10. Burberry A, [15 authors; Merkle FT: 9], Eggan K. Loss-of-function mutations in the C9ORF72 mouse ortholog cause fatal autoimmune disease. Sci Transl Med. 2016;8:347ra93. *
  11. Burke LK, [17 authors], Evans ML, Heisler LK. Sex difference in physical activity, energy expenditure and obesity driven by a subpopulation of hypothalamic POMC neurons. Mol Metab. 2016;5:245-52. *
  12. Carmody D, Ladsaria SS, Buikema RK, Semple RK, Greeley SAW. Successful rhIGF1 treatment for over 5 years in a patient with severe insulin resistance due to homozygous insulin receptor mutation. Diabet Med. 2016;33:e8-12. *
  13. Castillo SD, [26 authors; Semple RK: 23], Vanhaesebroeck B. Somatic activating mutations in Pik3ca cause sporadic venous malformations in mice and humans. Sci Transl Med. 2016;8:332ra43.
  14. Challis BG, Kandasamy N, Powlson AS, Koulouri O, Annamalai AK, Happerfield L, Marker AJ, Arends MJ, Nik-Zainal S, Gurnell M. Familial adrenocortical carcinoma in association with Lynch syndrome. J Clin Endocrinol Metab. 2016;101:2269-72. *
  15. Challis BG, Lim CT, Cluroe A, Cameron E, O’Rahilly S. The McKittrick-Wheelock syndrome: a rare cause of curable diabetes. Endocrinol Diabetes Metab Case Rep. 2016;160013. *
  16. Collet TH, van der Klaauw AA, Henning E, Keogh JM, Suddaby D, Dachi SV, Dunbar S, Kelway S, Dickson SL, Farooqi IS, Schmid SM. The sleep/wake cycle is directly modulated by changes in energy balance. Sleep 2016;39:1691-700. *
  17. Correia-Melo C, [26 authors; Vidal-Puig A: 19], Passos JF. Mitochondria are required for pro-ageing features of the senescent phenotype. EMBO J. 2016;35:724-42.*
  18. Dalgaard K, [28 authors; Yeo GS: 19, O’Rahilly S: 20, Coll AP: 27], Pospisilik JA. Trim28 haploinsufficiency triggers bi-stable epigenetic obesity. Cell 2016;164:353-64. *
  19. Demir T, Onay H, Savage DB, Temeloglu E, Uzum AK, Kadioglu P, Altay C, Ozen S, Demir L, Cavdar U, Akinci B. Familial partial lipodystrophy linked to a novel peroxisome proliferator activator receptor -γ (PPARG) mutation, H449L: a comparison of people with this mutation and those with classic codon 482 Lamin A/C (LMNA) mutations. Diabet Med. 2016;33:1445-50.
  20. Dennedy MC, Annamalai AK, Prankerd Smith O, Freeman N, Vengopal K, Graggaber J, Koulouri O, Powlson AS, Shaw A, Halsall DJ, Gurnell M. Low DHEAS: a sensitive and specific test for detection of subclinical hypercortisolism in adrenal incidentalomas. J Clin Endocrinol Metab. 2016;jc20162718.
  21. Diederen KM, Spencer T, Vestergaard MD, Fletcher PC, Schultz W. Adaptive prediction error coding in the human midbrain and striatum facilitates behavioural adaptation and learning efficiency. Neuron. 2016;90:1127-38. doi: *
  22. Duque-Guimarães DE, de Almeida-Faria J, Ong TP, Ozanne SE. Pulsed SILAC as a approach for miRNA targets identification in cell culture. Methods Mol Biol. 2017;1546:149-59.
  23. Dusaulcy R, Handgraaf S, Heddad-Masson M, Visentin F, Vesin C, Reimann F, Gribble F, Philippe J, Gosmain Y. α-cell dysfunctions and molecular alterations in male insulinopenic diabetic mice are not completely corrected by insulin. Endocrinology 2016;157:536-47.
  24. Edgar RS, Stangherlin A, Nagy AD, Nicoll MP, Efstathiou S, O’Neill JS, Reddy AB. Cell autonomous regulation of herpes and influenza virus infection by the circadian clock. Proc Natl Acad Sci USA. 2016;113:10085-90. *
  25. Ekberg JH, [14 authors; Gribble FM: 10, Reiman F: 11], Schwartz TW. GPR119, a major enteroendocrine sensor of dietary triglyceride metabolites coacting in synergy With FFA1 (GPR40). Endocrinology 2016;157:4561-9.
  26. Farrington C, Allen J, Tauschmann M, Randell T, Trevelyan N, Hovorka R. Factors affecting recruitment of participants for studies of diabetes technology in newly diagnosed youth with type 1 diabetes: a qualitative focus group study with parents and children. Diabetes Technol Ther. 2016;18:568-73. *
  27. Flint TR, Janowitz T, Connell CM, Roberts EW, Denton AE, Coll AP, Jodrell DI, Fearon DT. Tumor-induced IL-6 reprograms host metabolism to suppress anti-tumor immunity. Cell Metab. 2016;24:672-84. *
  28. Fuchsberger C, [301 authors; O’Rahilly SP: 208], McCarthy MI. The genetic architecture of type 2 diabetes. Nature 2016;536:41-7. *
  29. Gathercole LL, [13 authors; Semple RK: 11], Geberhiwot T. Advanced non-alcoholic fatty liver disease and adipose tissue fibrosis in patients with Alström syndrome. Liver Int. 2016;36:1704-12.
  30. Giraud K, Pontin M, Sharples LD, Fletcher P, Dalgleish T, Eden A, Jenkins DP, Vuylsteke A. Use of a structured mirrors intervention does not reduce delirium incidence but may improve factual memory encoding in cardiac surgical ICU patients aged over 70 years: a pilot time-cluster randomized controlled trial. Front Aging Neurosci. 2016;8:228.
  31. Gripp KW, Baker L, Kandula V, Conard K, Scavina M, Napoli JA, Griffin GC, Thacker M, Knox RG, Clark GR, Parker VER, Semple R, Mirzaa G, Keppler-Noreuil KM. Nephroblastomatosis or Wilms tumor in a fourth patient with a somatic PIK3CA mutation. Am J Med Genet A. 2016;170:2559-69.
  32. Groeneveld MP, Brierley GV, Rocha NM, Siddle K, Semple RK. Acute knockdown of the insulin receptor or its substrates Irs1 and 2 in 3T3-L1 adipocytes suppresses adiponectin production. Sci Rep. 2016 Feb 18;6:21105. *
  33. Hall Z, Bond NJ, Ashmore T, Sanders F, Ament Z, Wang X, Murray AJ, Bellafante E, Virtue S, Vidal-Puig A, Allison M, Davies SE, Koulman A, Vacca M, Griffin JL. Lipid zonation and phospholipid remodeling in nonalcoholic fatty liver disease. Hepatology 2016;epub ahead of print.
  34. Heppolette CA, Chen JH, Carr SK, Palmer DB, Ozanne SE. The effects of aging and maternal protein restriction during lactation on thymic involution and peripheral immunosenescence in adult mice. Oncotarget 2016;7:6398-409. *
  35. Holland ML, Lowe R, Caton PW, Gemma C, Carbajosa G, Danson AF, Carpenter AA, Loche E, Ozanne SE, Rakyan VK. Early-life nutrition modulates the epigenetic state of specific rDNA genetic variants in mice. Science 2016;353:495-8.
  36. Hollands GJ, Marteau TM, Fletcher PC. Non-conscious processes in changing health-related behaviour: a conceptual analysis and framework. Health Psychol Rev. 2016;10:381-394. *
  37. Huang-Doran I, [18 authors], Savage DB, Murphy R, O’Rahilly S, Barroso I, Semple RK. Insulin resistance uncoupled from dyslipidemia due to C-terminal PIK3R1 mutations. JCI Insight. 2016;1:e88766. *
  38. Inman M, Daneman D, Curtis J, Sochett E, Elia Y, Dunger DB, Deanfield J, Mahmud FH. Assessing social determinants of health in a pediatric diabetes clinical research trial: Are recruited subjects representative of the larger clinical population? Diabetes Res Clin Pract. 2016;113:41-3.
  39. Joustra SD, Heinen CA, Schoenmakers N, Bonomi M, Ballieux BEPB, Turgeon MO, Bernard DJ, Fliers E, van Trotsenburg ASP, Losekoot M, Persani L, Wit JM, Biermasz NR, Pereira AM, Oostdijk W, Group ICC. IGSF1 deficiency: lessons from an extensive case series and recommendations for clinical management. J Clin Endocrinol Metab. 2016;101:1627-36. *
  40. Joustra SD, Schoenmakers N, [26 authors; Chatterjee K: 22], van Trotsenburg AS. The IGSF1 deficiency syndrome: characteristics of male and female patients. J Clin Endocrinol Metab. 2013;98:4942-52.
  41. Kandasamy N, Garfinkel SN, Page L, Hardy B, Critchley HD, Gurnell M, Coates JM. Interoceptive ability predicts survival on a London trading floor. Sci Rep. 2016;6:32986. *
  42. Kilpeläinen TO, [175 authors; Savage DB: 99], Loos RJ. Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels. Nat Commun. 2016;7:10494. *
  43. Kim HS, [15 authors; Yeo GS: 9], Lee MG. A coding variant in FTO confers susceptibility to thiopurine-induced leukopenia in East Asian patients with IBD. Gut 2016;pii:gutjnl-2016-311921.
  44. Koulouri O, Hoole AC, English P, Allinson K, Antoun N, Cheow H, Burnet NG, Donnelly N, Mannion RJ, Gurnell M. Localisation of an occult thyrotropinoma with (11)C-methionine PET-CT before and after somatostatin analogue therapy. Lancet Diabetes Endocrinol. 2016;4:1050.
  45. Koulouri O, [28 authors], Gurnell M. Successful treatment of residual pituitary adenoma in persistent acromegaly following localisation by 11C-methionine PET co-registered with MRI. Eur J Endocrinol. 2016;175:485-98.
  46. Koulouri O, Nicholas AK, Schoenmakers E, Mokrosinski J, Lane F, Cole T, Kirk J, Farooqi IS, Chatterjee VK, Gurnell M, Schoenmakers N. A novel thyrotropin-releasing hormone receptor missense mutation (P81R) in central congenital hypothyroidism. J Clin Endocrinol Metab. 2016;101:847-51. *
  47. Kuhre RE, Wewer Albrechtsen NJ, Deacon CF, Balk-Møller E, Rehfeld JF, Reimann F, Gribble FM, Holst JJ. Peptide production and secretion in GLUTag, NCI-H716, and STC-1 cells: a comparison to native L-cells. J Mol Endocrinol. 2016;56:201-11.
  48. Langeveld M, Tan CY, Soeters MR, Virtue S, Ambler GK, Watson LP, Murgatroyd PR, Chatterjee VK, Vidal-Puig A. Mild cold effects on hunger, food intake, satiety and skin temperature in humans. Endocr Connect. 2016;5:65-73. *
  49. Leelarathna L, Thabit H, Hartnell S, Willinska ME, Dellweg S, Benesch C, Mader JK, Holzer M, Kojzar H, Evans ML, Arnolds S, Pieber TR, Hovorka R, AP@home Consortium. Rapid benefits of structured optimization and sensor-augmented insulin pump therapy in adults with type 1 diabetes. J Diabetes Sci Technol. 2016;pii:1932296816654715.
  50. Lie S, Morrison JL, Williams-Wyss O, Suter CM, Humphreys DT, Ozanne SE, Zhang S, MacLaughlin SM, Kleemann DO, Walker SK, Roberts CT, McMillen IC. Impact of maternal undernutrition around the time of conception on factors regulating hepatic lipid metabolism and microRNAs in singleton and twin fetuses. Am J Physiol Endocrinol Metab. 2016;310:E148-59. *
  51. Lotta LA, [26 authors; O’Rahilly S: 25], Langenberg C. Genetic predisposition to an impaired metabolism of the branched-chain amino acids and risk of type 2 diabetes: a mendelian randomisation analysis. PLoS Med. 2016;13:e1002179. *
  52. Lotta LA, [39 authors; O’Rahilly S: 35], Wareham NJ. Association between low-density lipoprotein cholesterol-lowering genetic variants and risk of type 2 diabetes: a meta-analysis. JAMA 2016;316:1383-91.
  53. Lu L, Koulman A, Petry CJ, Jenkins B, Matthews L, Hughes IA, Acerini CL, Ong KK, Dunger DB. An unbiased lipidomics approach identifies early second trimester lipids predictive of maternal glycemic traits and gestational diabetes mellitus. Diabetes Care 2016;39:2232-9. *
  54. Maahs DM, [22 authors; Hovorka R: 11], Lum JW. Outcome Measures for Artificial Pancreas Clinical Trials: A Consensus Report. Diabetes Care 2016;39:1175-9.
  55. Majithia AR, [24 authors, O’Rahilly S: 19], Altshuler D. Prospective functional classification of all possible missense variants in PPARG. Nat Genet. 2016;48:1570-5. *
  56. Manning KE, McAllister CJ, Ring HA, Finer N, Kelly CL, Sylvester KP, Fletcher PC, Morrell NW, Garnett MR, Manford MR, Holland AJ. Novel insights into maladaptive behaviours in Prader-Willi syndrome: serendipitous findings from an open trial of vagus nerve stimulation. J Intellect Disabil Res. 2016;60:149-55. *
  57. Marelli F, Carra S, Agostini M, Cotelli F, Peeters R, Chatterjee K, Persani L. Patterns of thyroid hormone receptor expression in zebrafish and generation of a novel model of resistance to thyroid hormone action. Mol Cell Endocrinol. 2016;424:102-17.
  58. Martin-Gronert MS, Fernandez-Twinn DS, Bushell M, Siddle K, Ozanne SE. Cell-autonomous programming of rat adipose tissue insulin signalling proteins by maternal nutrition. Diabetologia 2016;59:1266-75. *
  59. Martin-Gronert MS, Stocker CJ, Wargent ET, Cripps RL, Garfield AS, Jovanovic Z, D’Agostino G, Yeo GS, Cawthorne MA, Arch JR, Heisler LK, Ozanne SE. 5-HT2A and 5-HT2C receptors as hypothalamic targets of developmental programming in male rats. Dis Model Mech. 2016;9:401-12.*
  60. Martínez R, Kapravelou G, Porres JM, Melesio AM, Heras L, Cantarero S, Gribble FM, Parker H, Aranda P, López-Jurado M. Medicago sativa L, a functional food to relieve hypertension and metabolic disorders in a spontaneously hypertensive rat model. Journal of Functional Foods 2016;26:470-84.
  61. Medic N, Ziauddeen H, Ersche KD, Farooqi IS, Bullmore ET, Nathan PJ, Ronan L, Fletcher PC. Increased body mass index is associated with specific regional alterations in brain structure. Int J Obes (Lond). 2016;40:1177-82. *
  62. Medic N, Ziauddeen H, Forwood SE, Davies KM, Ahern AL, Jebb SA, Marteau TM, Fletcher PC. The presence of real food usurps hypothetical health value judgment in overweight people. 2016;3.pii: ENEURO.0025-16.2016. *
  63. Meek CL, Lewis HB, Vergese B, Park A, Reimann F, Gribble F. The effect of encapsulated glutamine on gut peptide secretion in human volunteers. Peptides 2016;77:38-46. *
  64. Morton NM, [31 authors; Vidal-Puig A: 29], Horvat S. Genetic identification of thiosulfate sulfurtransferase as an adipocyte-expressed antidiabetic target in mice selected for leanness. Nat Med. 2016;22:771-9.
  65. Moss CE, Glass LL, Diakogiannaki E, Pais R, Lenaghan C, Smith DM, Wedin M, Bohlooly-Y M, Gribble FM, Reimann F. Lipid derivatives activate GPR119 and trigger GLP-1 secretion in primary murine L-cells. Peptides 2016 Mar;77:16-20. *
  66. Musial B, Fernandez-Twinn DS, Vaughan OR, Ozanne SE, Voshol P, Sferruzzi-Perri AN, Fowden AL. Proximity to delivery alters insulin sensitivity and glucose metabolism in pregnant mice. Diabetes 2016;65:851-60. *
  67. Neupane S, Peverall R, Richmond G, Blaikie TP, Taylor D, Hancock G, Evans ML. Exhaled breath isoprene rises during hypoglycemia in type 1 diabetes. Diabetes Care 2016;39:e97-8.
  68. Nicholas AK, [33 authors], Chatterjee VK, Anderson CA, Schoenmakers N. Comprehensive screening of eight known causative genes in congenital hypothyroidism with gland-in-situ. J Clin Endocrinol Metab. 2016;101:4521-31. *
  69. Nicholas AK, Jaleel S, Lyons G, Schoenmakers E, Dattani MT, Crowne E, Bernhard B, Kirk J, Roche EF, Chatterjee VK, Schoenmakers N. Molecular spectrum of TSHβ subunit gene defects in central hypothyroidism in the UK and Ireland. Clin Endocrinol (Oxf). 2016; Epub ahead of print.
  70. Novoselova TV, Larder R, Rimmington D, Lelliott C, Wynn EH, Gorrigan RJ, Tate PH, Guasti L; Sanger Mouse Genetics Project, O’Rahilly S, Clark AJ, Logan DW, Coll AP, Chan LF. Loss of Mrap2 is associated with Sim1 deficiency and increased circulating cholesterol. J Endocrinol. 2016;230:13-26. *
  71. Overduin J, Collet TH, Medic N, Henning E, Keogh JM, Forsyth F, Stephenson C, Kanning MW, Ruijschop RM, Farooqi IS, van der Klaauw AA. Failure of sucrose replacement with the non-nutritive sweetener erythritol to alter GLP-1 or PYY release or test meal size in lean or obese people. Appetite 2016;107:596-603. *
  72. Pais R, Gribble FM, Reimann F. Signalling pathways involved in the detection of peptones by murine small intestinal enteroendocrine L-cells. Peptides 2016;77:9-15. *
  73. Pais R, Rievaj J, Larraufie P, Gribble F, Reimann F. Angiotensin II type 1 receptor-dependent GLP-1 and PYY secretion in mice and humans. Endocrinology 2016;157:3821-3831. *
  74. Pais R, Rievaj J, Meek C, De Costa G, Jayamaha S, Alexander RT, Reimann F, Gribble F. Role of enteroendocrine L-cells in arginine vasopressin-mediated inhibition of colonic anion secretion. J Physiol. 2016;594:4865-78. *
  75. Parvaresh Rizi E, Baig S, Shabeer M, Teo Y, Mok SF, Loh TP, Magkos F, Virtue S, Vidal-Puig A, Tai ES, Khoo CM, Toh SA. Meal rich in carbohydrate, but not protein or fat, reveals adverse immunometabolic responses associated with obesity. Nutr J. 2016;15:100. *
  76. Pauliina Markkula S, Lyons D, Yueh CY, Riches C, Hurst P, Fielding B, Heisler LK, Evans ML. Intracerebroventricular catalase reduces hepatic insulin sensitivity and increases responses to hypoglycemia in rats. Endocrinology 2016;157:4669-76. *
  77. Petry CJ, Sanz Marcos N, Pimentel G, Hayes MG, Nodzenski M, Scholtens DM, Hughes I A, Acerini CL, Ong KK, Lowe WL, Dunger DB. Associations between fetal imprinted genes and maternal blood pressure in pregnancy. Hypertension 2016;68:1459-66.
  78. Powlson AS, Challis BG, Halsall DJ, Schoenmakers E, Gurnell M. Nephrogenic syndrome of inappropriate antidiuresis secondary to an activating mutation in the arginine vasopressin receptor AVPR2. Clin Endocrinol (Oxf). 2016;85:306-12.
  79. Pozzilli P, Battelino T, Danne T, Hovorka R, Jarosz-Chobot P, Renard E. Continuous subcutaneous insulin infusion in diabetes: patient populations, safety, efficacy, and pharmacoeconomics. Diabetes Metab Res Rev. 2016;32:21-39. *
  80. Psichas A, Glass LL, Sharp SJ, Reimann F, Gribble FM. Galanin inhibits GLP-1 and GIP secretion via the GAL1 receptor in enteroendocrine L and K cells. Br J Pharmacol. 2016;173:888-98. *
  81. Raffan E, [19 authors], Yeo GS, O’Rahilly S. A deletion in the canine POMC Gene is associated with weight and appetite in obesity-prone Labrador Retriever dogs. Cell Metab. 2016;23:893-900. *
  82. Rahbari R, Wuster A, Lindsay SJ, Hardwick RJ, Alexandrov LB, Al Turki S, Dominiczak A, Morris A, Porteous D, Smith B, Stratton MR, UK10K Consortium, Hurles ME. Timing, rates and spectra of human germline mutation. Nat Genet. 2016;48:126-33. *
  83. Rey G, Valekunja UK, Feeney KA, Wulund L, Milev NB, Stangherlin A, Ansel-Bollepalli L, Velagapudi V, O’Neill JS, Reddy AB. The pentose phosphate pathway regulates the circadian clock. Cell Metab. 2016;24:462-73. *
  84. Richards P, Pais R, Habib AM, Brighton CA, Yeo GS, Reimann F, Gribble FM. High fat diet impairs the function of glucagon-like peptide-1 producing L-cells. Peptides 2016;77:21-7. *
  85. Rodriguez-Cuenca S, Whyte L, Hagen R, Vidal-Puig A, Fuller M. Stearoyl-CoA Desaturase 1 is a key determinant of membrane lipid composition in 3T3-L1 adipocytes. PLoS One 2016;11:e0162047. *
  86. Ronan L, Alexander-Bloch AF, Wagstyl K, Farooqi S, Brayne C, Tyler LK; Cam-CAN, Fletcher PC. Obesity associated with increased brain age from midlife. Neurobiol Aging. 2016;47:63-70. *
  87. Rowe ER, Mimmack ML, Barbosa AD, Haider A, Isaac I, Ouberai MM, Thiam AR, Patel S, Saudek V, Siniossoglou S, Savage DB. Conserved amphipathic helices mediate lipid droplet targeting of perilipins 1-3. J Biol Chem. 2016;291:6664-78. *
  88. Ruan Y, [12 authors], Hovorka R, AP@home Consortium. Variability of insulin requirements over 12 weeks of closed-loop insulin delivery in adults with type 1 diabetes. Diabetes Care 2016;39:830-2.
  89. Sandovici I, Hammerle CM, Cooper WN, Smith NH, Tarry-Adkins JL, Dunmore BJ, Bauer J, Andrews SR, Yeo GS, Ozanne SE, Constância M. Ageing is associated with molecular signatures of inflammation and type 2 diabetes in rat pancreatic islets. Diabetologia 2016;59:502-11. *
  90. Sanghez V, Cubuk C, Sebastian-Leon P, Carobbio S, Dopazo J, Vidal-Puig A, Bartolomucci A. Chronic subordination stress selectively downregulates the insulin signaling pathway in liver and skeletal muscle but not in adipose tissue of male mice. Stress 2016;19:214-24. *
  91. Santos DP, Kiskinis E, Eggan K, Merkle FT. Comprehensive protocols for CRISPR/Cas9-based gene editing in human pluripotent stem cells. Curr Protoc Stem Cell Biol. 2016;38:5B.6.1-5B.6.60. *
  92. Sayers SR, Reimann F, Gribble FM, Parker H, Zac-Varghese S, Bloom SR, Foretz M, Viollet B, Rutter GA. Proglucagon promoter Cre-mediated AMPK deletion in mice increases circulating GLP-1 levels and oral glucose tolerance. PLoS One 2016;11:e0149549. *
  93. Schoenmakers E, [14 authors; Farooqi S: 12], Chatterjee K. Mutation in human selenocysteine transfer RNA selectively disrupts selenoprotein synthesis. J Clin Invest. 2016;126:992-6. *
  94. Schooneman MG, Napolitano A, Houten SM, Ambler GK, Murgatroyd PR, Miller SR, Hollak CE, Tan CY, Virtue S, Vidal-Puig A, Nunez DJ, Soeters MR. Assessment of plasma acylcarnitines before and after weight loss in obese subjects. Arch Biochem Biophys. 2016;606:73-80.
  95. Scott RA, [148 authors; O’Rahilly S: 138], Waterworth DM. A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease. Sci Transl Med. 2016;8:341ra76. *
  96. Sefton C, Harno E, Davies A, Small H, Allen TJ, Wray JR, Lawrence CB, Coll AP, White A. Elevated hypothalamic glucocorticoid levels are associated with obesity and hyperphagia in male mice. Endocrinology 2016;157:4257-65. *
  97. Segarra N, Metastasio A, Ziauddeen H, Spencer J, Reinders NR, Dudas RB, Arrondo G, Robbins TW, Clark L, Fletcher PC, Murray GK. Abnormal frontostriatal activity during unexpected reward receipt in depression and schizophrenia: relationship to anhedonia. 2016;41:2001-10. *
  98. Sferruzzi-Perri AN, López-Tello J, Fowden AL, Constancia M. Maternal and fetal genomes interplay through phosphoinositol 3-kinase(PI3K)-p110α signaling to modify placental resource allocation. Proc Natl Acad Sci USA. 2016;113:11255-60. *
  99. Sleigh A, Lupson V, Thankamony A, Dunger DB, Savage DB, Carpenter TA, Kemp GJ. Simple and effective exercise design for assessing in vivo mitochondrial function in clinical applications using (31)P magnetic resonance spectroscopy. Sci Rep. 2016;6:19057. *
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