Publications - Wellcome-MRC Institute of Metabolic Science

Primary Research Publications

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2021

Ahmed RM, Tse Ny, Chen Y, Henning E, Hodges JR, Kiernan MC, Irish M, Farooqi IS, Piguet O. Neural correlates of fat preference in frontotemporal dementia: translating insights from the obesity literature. Ann Clin Transl Neurol. 2021 Jun;8(6):1318-1329. doi: 10.1002/acn.51369. PMID:33973740
Artero-Castro A, Long K, Bassett A, Avila-Fernandez A, Corton M, Vidal-Puig A, Jendelova P, Rodriguez-Jimenez FJ, Clemente E, Ayuso C, Slaven E, Gene Correction Recovers Phagocytosis in Retinal Pigment Epithelium Derived from Retinitis Pigmentosa-Human-Induced Pluripotent Stem Cells. Int J Mol Sci. 2021 Feb 20;22(4):2092. doi: 10.3390/ijms22042092. PMID:33672445 PMCID:PMC7923278
Azzu V, Vacca M, Kamzolas I, Hall Z, Leslie J, Carobbio S, Virtue S, Virtue S, Davies SE, Lukasik A, Dale M, Bohlooly-Y M, Acharjee A, Linden D, Bidault G, Petsalaki E, Griffin JL, Oakley F, Allison ME, Vidal-Puig A. Suppression of insulin-induced gene 1 (INSIG1) function promotes hepatic lipid remodelling and restrains NASH progression. Mol Metab. 2021 Mar 12:101210. doi: 10.1016/jmolmet.2021.101210. PMID:33722690
Biglari N, Gaziano I, Schumacher J, Radermacher J, Paeger L, Klemm P, Chen W, Corneliussen S, Wunderlich CM, Sue M, Vollmar S, Klöckener T, Sotelo-Hitschfeld T, Abbasloo A, Edenhofer F, Reimann F, Gribble FM, Fenselau H, Kloppenburg P, Wunderlich FT, Brüning JC. Functionally distinct POMC-expressing neuron subpopulations in hypothalamus revealed by intersectional targeting. Nat Neurosci. 2021 May 17. doi: 10.1038/s41593-021-00854-0. PMID:34002087
Beardsall K, Thomason L, Guy C, Iglesias-Platas I, van Weissenbruch MM, Bond S, Allison A, Kim S, Petrou S, Pantaleo B, Hovorka R, Dunger D; REACT collaborative. Real-time continuous glucose monitoring in preterm infants (REACT): an international, open-label, randomised controlled trial. Lancet Child Adolesc Health. 2021 Feb 9:S2352-4642(20)30367-9. doi: 10.1016/S2352(20)30367-9. PMID:33577770
Boughton CK, Daly A, Thabit H, Hartnell S, Herzig D, Vogt A, Ruan Y, Wilinska ME, Evans ML, Coll AP, Bally L, Hovorka R. Day-to-day variability of insulin requirements in the inpatient setting: observations during fully closed-loop insulin delivery. Diabetes Obes Metab. 2021 Apr 6. doi: 10.1111/dom.14396. PMID33822461
Boughton CK, Hartnell S, Thabit H, Poettler T, Herzig D, Wilinska ME, Ashcroft NL, Sibayan J, Cohen N, Calhoun P, Bally L, Mader JK, Evans M, Leelarathna L, Hovorka R. Hybrid closed-loop glucose control with faster insulin aspart (Fiasp) compared with standard insulin aspart in adults with type 1 diabetes: a double-blind, multicentre, multinational, randomised, crossover study. Diabetes Obes Metab. 2021 Feb 19. doi:10.1111/dom.14355. PMID:33606901
Boughton CK, Hovorka R. Correction to: New closed-loop insulin systems. Diabetologia. 2021 Mar 22. doi: 10.1007/s00125-021-05443-1. PMID:33751132
Boughton CK, Hovorka R. Can exenatide flatten the post-prandial glucose curve in type 1 diabetes? Ann Transl Med. 2020 Nov;8(22):1535. doi: 10.21037/atm-20-3654. PMID:33313280 PMCID:PMC7729374
Boughton CK, Hovorka R. New closed-loop insulin systems. Diabetologia. 2021 Feb 6. doi: 10.1007/s00125-021-05391-w. PMID:33550442
Brierley DI, Holt MK, Singh A, de Araujo A, McDougle M, Vergara M, Afaghani MH, Lee SJ, Scott K, Maske C, Langhans W, Krause E, de Kloet A, Gribble FM, Reimann F, Rinaman L, de Lartigue G, Trapp S. Central and peripheral GLP-1 systems independently suppress eating. Nat Metab. 2021 Feb;3(2):258-273. doi: 10.1038/s42255-021-00344-4. PMID: 33589843 PMCID:PMC7116821
Brocklebank LA, Blackwell AKM, Marteau TM, Hollands GJ, Fletcher PC, De-Loyde K, Morris RW, Pilling MA, Pechey R, Maynard OM, Attwood AS, Munafò MR. Straight-sided beer and cider glasses to reduce alcohol sales for on-site consumption: A randomised crossover trial in bars. Soc Sci Med. 2021 Jun;278:113911.doi:10.1016/j.socscimed.2021.113911. PMID:33962320 PMCID:PMC8146727
Brouwers B, Mendes de Oliveira E, Marti-Solano M, Monteiro FBF, Laurin SA, Keogh JM, Henning E, Bounds R, Daly CA, Houston S, Ayinampudi V, Wasiluk N, Clarke D, Plouffe B, Bouvier M, Babu MM, Farooqi IS, Mokrosiński J. Human MC4R variants affect endocytosis, traffickingand dimerization revealing multiple cellularmechanisms involved in weight regulation. Cell Reports, 23 March 2021, 34, 108862. PMID: 33761344 PMCID:PMC7994375
Burke LK, Darwish T, Cavanaugh AR, Virtue S, Roth E, Morro J, Liu SM, Xia J, Dalley JW, Burling K, Chua S, Vidal-Puig T, Schwartz GJ, Blouet C. mTORC1 in AGRP neurons integrates exteroceptive and interoceptive food-related cues in the modulation of adaptive energy expenditure in mice. Elife. 2017 May 23;6:e22848. doi: 10.7554/eLife.22848. PMID:28532548 PMCID:PMC5441868
Camm EJ, Cross CM, Kane AD, Tarry-Adkins JL, Ozanne SE, Giussani DA. Maternal antioxidant treatment protects adult offspring against memory loss and hippocampal atrophy in a rodent model of developmental hypoxia. FASEB J. 2021 May;35(5):e21477. doi: 10.1096/fj.202002557RR. PMID:33891326
Carobbio S, Guenantin AC, Bahri M, Rodriguez-Fdez S, Hong F Kamzolas I, Samuelson I, Lond K, Awad S, Lukovic D, Erceg S, Bassett A, Mendjan S, Vallier L, Rosen BS, Chiarugi D, Vidal-Puig A. Unravelling the development roadmap towards human brown adipose tissue. Stem Cell Reports. 2021 Feb 6;S2213 6711(21)00043-6. doi: 10.1016/j.stemcr.2021.01.013. PMID:33606988 PMCID:PMC7940445
Chen NS, Boughton CK, Hartnell S, Fuchs J, Allen JM, Willinska ME, Thankamony A, de Beaufort C, Campbell FM, Fröhlich-Reiterer E, Hofer SE, Kapellen TM, Rami-Merhar B, Ghatak A, Randell TL, Besser REJ, Elleri D, Trevelyan N, Denvir L, Davis N, Gurnell E, Lindsay R, Morris D, Scott EM, Bally L, Thabit H, Leelarathna L, Evans ML, Murphy HR, Mader JK, Hovorka R; AiDAPT, AP@home04, CLOuD, DAN05, DAN06, and KidsAP consortia. User Engagement With the CamAPS FX Hybrid Closed-Loop App According to Age and User Characteristics. Diabetes Care. 2021 May 21;dc202762. doi: 10.2337/dc20-2762. PMID:34021021
Choi RJ, Mohamad Zobir SZ, Alexander-Dann B, Sharma N, Ma MKL, Lam BYH, Yeo GSH, Zhang W, Fan TP, Bender A. Combination of Ginsenosides Rb2 and Rg3 Promotes Angiogenic Phenotype of Human Endothelial Cells via PI3K/Akt and MAPK/ERK Pathways. Front Pharmacol. 2021 Feb 10;12:618773. doi: 10.3389/fphar.2021.618773. PMID:33643049 PMCID:PMC7902932
Corrales P, Vidal-Puig A, Medina-Gómez G. Obesity and pregnancy, the perfect metabolic storm. Eur J Clin Nutr. 2021 Apr 28. doi: 10.1038/s41430-021-00914-5. PMID:33911209
Daly A, Hovorka R. Technology in the management of type 2 diabetes: Present status and future prospects. Diabetes Obes Metab. 2021 May 5. doi: 10.1111/dom.14418. PMID:33950566
Di Cicco E, Moran C, Visser WE, Nappi A, Schoenmakers E, Todd P, Lyons G, Dattani M, Ambrosio R, Parisi S, Salvatore D, Chatterjee VK, Dentice M. Germline mutations in the thyroid hormone receptor alpha gene predispose to cutaneous tags and melanocytic nevi. Thyroid. 2021 Jan 28. doi: 10.1089/thy.2020.0391. PMID:33509032
Dolezalova N, Gruszczyk A, Barkan K, Gamble JA, Galvin S, Moreth T, O’Holleran K, Mahbubani KT, Higgins JA, Gribble FM, Reimann F, Surmacki J, Andrews S, Casey JJ, Pampaloni F, Murphy MP, Ladds G, Slater NKH, Saeb-Parsy K. Accelerating cryoprotectant diffusion kinetics improves cryopreservation of pancreatic islets. Sci Rep. 2021 May 17;11(1):10418. doi: 10.1038/s41598-021-89853-6. PMID:34001961 PMCID:PMC8129116
Dowsett GKC, Lam BYH, Tadross JA, Cimino I, Rimmington D, Coll AP, Polex-Wolf J, Knudsen LB, Pyke C, Yeo GSH. A survey of the mouse hindbrain in the fed and fasted state using single-nucleus RNA sequencing. Mol Metab. 2021 May 4;101240. doi: 10.1016/j.molmet.2021.101240. PMID:33962048
Fabricius TW, Verhulst CEM, Kristensen PL, Tack CJ, McCrimmon RJ, Heller S, Evans ML, Amiel SA, Pieber TR, de Galan BE, Pedersen-Bjergaard U; Hypo-RESOLVE consortium. Hyperinsulinaemic-hypoglycaemic glucose clamps in human research: a systematic review of the literature. Diabetologia. 2021 Feb 10. doi: 10.1007/s00125-020-05361-8. PMID:33566134
Finnemann JJS, Plaisted-Grant K, Moore J, Teufel C, Fletcher PC. Low-level, prediction-based sensory and motor processes are unimpaired in Autism. Neuropsychologia. 2021 Mar 29;156:107835. doi: 10.1016/j.neuropsychologia.2021.107835. PMID:33794277
Fox RA, Patient CJ, Aiken AR, Meek CL, Aiken CE. Temporal variations in maternal treatment requirements and early neonatal outcomes in patients with gestational diabetes. Diabet Med. 2021 May 8:e14596. doi: 10.1111/dme.14596. PMID:33963609
Fuchs J, Allen JM, Boughton CK, Wilinska ME, Thankamony A, de Beaufort C, Campbell F, Yong J, Froehlich-Reiterer E, Mader JK, Hofer SE, Kapellen TM, Rami-Merhar B, Tauschmann M, Hood K, Kimbell B, Lawton J, Roze S, Sibayan J, Cohen N, Hovorka R; KidsAP Consortium. Assessing the efficacy, safety and utility of closed-loop insulin delivery compared with sensor-augmented pump therapy in very young children with type 1 diabetes (KidsAP02 study): an open-label, multicentre, multinational, randomised cross-over study protocol. BMJ Open. 2021 Feb 12;11(2):e042790. doi: 10.1136/bmjopen-2020-042790. PMID: 33579766 PMC7883854
Fuchs J, Hovorka R. Benefits and Challenges of Current Closed-Loop Technologies in Children and Young People With Type 1 Diabetes. Front Pediatr. 2021 Apr 30;9:679484. doi: 10.3389/fped.2021.679484. eCollection 2021. Front Pediatr. 2021 Apr 30;9:679484. doi: 10.3389/fped.2021.679484. PMID:33996702 PMCID:PMC8119627
Furse S, Watkins AJ, Hojat N, Smith J, Williams HEL, Chiarugi D, Koulman A. Lipid Traffic Analysis reveals the impact of high paternal carbohydrate intake on offsprings’ lipid metabolism. Commun Biol. 2021 Feb 5;4(1):163. doi: 10.1038/s42003-021-01686-1. PMID:33547386 PMCID:PMC7864968
Gallant J, Chan K, Green TJ, Wieringa FT, Leemaqz S, Ngik R, Measelle JR, Baldwin DA, Borath M, Sophonneary P, Yelland LN, Hampel D, Shahab-Ferdows S, Allen LH, Jones KS, Koulman A, Parkington DA, Meadows SR, Kroeun H, Whitfield KC. Low-dose thiamine supplementation of lactating Cambodian mothers improves human milk thiamine concentrations: a randomized controlled trial. Am J Clin Nutr. 2021 Apr 7;nqab052. doi: 10.1093/ajcn/nqab052. PMID:33829271
Galvin SG, Larraufie P, Kay RG, Pitt H, Bernard E, McGavigan AK, Brandt H, Hood J, Sheldrake L, Conder S, Atherton-Kemp D, Lu VB, O’Flaherty EAA, Roberts GP, Ämmälä C, Jermutus L, Baker D, Gribble FM, Reimann F. Peptidomics of enteroendocrine cells and characterisation of potential effects of a novel preprogastrin derived-peptide on glucose tolerance in lean mice. Peptides. 2021 Mar 17:170532. doi: 10.1016/j.peptides.2021.170532. PMID:33744371
Gao M, Piernas C, Astbury NM, Hippisley-Cox J, O’Rahilly S, Aveyard P, Jebb SA. Associations between body-mass index and COVID-19 severity in 6·9 million people in England: a prospective, community-based, cohort study. Lancet Diabetes Endocrinol. 2021 Jun;9(6):350-359. doi: 10.1016/S2213-8587(21)00089-9. PMID:33932335 PMCID:PMC8081400
Gillett D, Marsden D, Ballout S, Attili B, Bird N, Heard S, Gurnell M, Mendichovszky IA, Aloj L. 3D printing 18 F radioactive phantoms for PET imaging. EJNMMI Phys. 2021 Apr 28;8(1):38. doi: 10.1186/s40658-021-00383-6. PMID:33909154 PMCID:PMC8081805
Gribble FM, O’Rahilly S. Obesity therapeutics: The end of the beginning. Cell Metab 2021;33:705-706. doi: 10.1016/j.cmet.2021.03.012. PMID:33826913
Gribble FM, Reimann F. Metabolic Messengers: glucagon-like peptide 1. Nat Metab. 2021 Feb;3(2):142-148. doi: 10.1038/s42255-020-00327-x. PMID: 33432200
Gurnell M, Heaney LG, Price D, Menzies-Gow A. Long-term corticosteroid use, adrenal insufficiency, and the need for steroid-sparing treatment in adult severe asthma. J Intern Med. 2021 Feb 17. doi: 10.1111/joim.13273. PMID:33598993
Hamed MO, Barlow AD, Dolezalova N, Khosla S, Sagar A, Gribble FM, Davies S, Murphy MP, Hosgood SA, Nicholson ML, Saeb-Parsy K. Ex vivo normothermic perfusion of isolated segmental porcine bowel: a novel functional model of the small intestine. BJS Open. 2021 Mar 5;5(2):zrab009. doi: 10.1093/bjsopen/zrab009. PMID:33839750 PMCID:PMC8038264
Heeley N, Kirwan P, Darwish T, Arnaud M, Evans ML, Merkle FT, Reimann F, Gribble FM, Blouet C. Rapid sensing of l-leucine by human and murine hypothalamic neurons: Neurochemical and mechanistic insights. Mol Metab. 2018 Apr;10:14-27. doi: 10.1016/j.molmet.2018.01.021. PMID29439854 PMCID:PMC5985239
Ho K, Fleseriu M, Kaiser U, Salvatori R, Brue T, Lopes MB, Kunz P, Molitch M, Camper SA, Gadelha M, Syro LV, Laws E, Reincke M, Nishioka H, Grossman A, Barkan A, Casanueva F, Wass J, Mamelak A, Katznelson L, van der Lely AJ, Radovick S, Bidlingmaier M, Boguszewski M, Bollerslev J, Hoffman AR, Oyesiku N, Raverot G, Ben-Shlomo A, Fowkes R, Shimon I, Fukuoka H, Pereira AM, Greenman Y, Heaney AP, Gurnell M, Johannsson G, Osamura RY, Buchfelder M, Zatelli MC, Korbonits M, Chanson P, Biermasz N, Clemmons DR, Karavitaki N, Bronstein MD, Trainer P, Melmed S. Pituitary Neoplasm Nomenclature Workshop: Does Adenoma Stand the Test of Time? J Endocr Soc. 2021 Feb 9;5(3):bvaa205. doi: 10.1210/jendso/bvaa205. PMID:33604494 PMCID:PMC7874572
Hornigold DC, Roth E, Howard V, Will S, Oldham S, Coghlan MP, Blouet C, Trevaskis JL. A GLP-1:CCK fusion peptide harnesses the synergistic effects on metabolism of CCK-1 and GLP-1 receptor agonism in mice. Appetite. 2018 Aug 1;127:334-340. doi: 10.1016/j.appet.2018.05.131. PMID:29782892 PMCID:PMC6026274
Huang, F.-Y., Sutcliffe, M.P.F. and Grabenhorst, F. (2021). Preferences for nutrients and sensory food qualities identify biological sources of economic values in monkeys. Proc Natl Acad Sci USA. 118(26): e2101954118. doi: 10.1073/pnas.2101954118. PMID: 34155111
Huang-Doran I, Kinzer AB, Jimenez-Linan M, Thackray K, Harris J, Adams CL, de Kerdanet M, Stears A, O’Rahilly S, Savage DB, Gorden P, Brown RJ, Semple RK. Ovarian hyperandrogenism and its response to gonadotropin-releasing hormone analogue therapy in primary severe insulin resistance. J Clin Endocrinol Metab. 2021 Apr 26:dgab275. doi: 10.1210/clinem/dgab275. PMID:33901270
Huang LO, Rauch A, Mazzaferro E, Preuss M, Carobbio S, Bayrak CS, Chami N, Wang Z, Schick UM, Yang N, Itan Y, Vidal-Puig A, den Hoed M, Mandrup S, Kilpeläinen TO, Loos RJF. Genome-wide discovery of genetic loci that uncouple excess adiposity from its comorbidities. Nat Metab. 2021 Feb;3(2):228-243. doi: 10.1038/s42255-021-00346-2. PMID:33619380
Im YR, Hunter H, de Gracia Hahn D, Duret A, Cheah Q, Dong J, Fairey M, Hjalmarsson C, Li A, Kai Lim H, McKeown L, Mitrofan CG, Rao R, Utukuri M, Rowe IA, Mann JP. A systematic review of animal models of NAFLD finds high fat, high fructose diets most closely resemble human NAFLD. Hepatology. 2021 May 11. doi: 10.1002/hep.31897. PMID:33973269
Jerber J, Seaton DD, Cuomo ASE, Kumasaka N, Haldane J, Steer J, Patel M, Pearce D, Andersson M, Bonder MJ, Mountjoy E, Ghoussaini M, Lancaster MA; HipSci Consortium, Marioni JC, Merkle FT, Gaffney DJ, Stegle O. Population-scale single-cell RNA-seq profiling across dopaminergic neuron differentiation. Nat Genet. 2021 Mar;53(3):304-312. doi: 10.1038/s41588-021-00801-6. PMID:33664506
Jones D, De Lucia Rolfe E, Rennie KL, Griep LMO, Kusinski LC, Hughes DJ, Brage S, Ong KK, Beardsall K, Meek CL. Antenatal Determinants of Childhood Obesity in High-Risk Offspring: Protocol for the DiGest Follow-Up Study. Nutrients. 2021 Mar 31;13(4):1156. doi: 10.3390/nu13041156. PMID:33807319 PMC8067255
Kanakis I, Alameddine M, Folkes L, Moxon S, Myrtziou I, Ozanne SE, Peffers MJ, Goljanek-Whysall K, Vasilaki A. Small-RNA Sequencing Reveals Altered Skeletal Muscle microRNAs and snoRNAs Signatures in Weanling Male Offspring from Mouse Dams Fed a Low Protein Diet during Lactation. Cells. 2021 May 11;10(5):1166. doi: 10.3390/cells10051166. PMID:34064819 PMCID:PMC8150574
Kanti V, Puder L, Jahnke I, Krabusch PM, Kottner J, Vogt A, Richter C, Andruck A, Lechner L, Poitou C, Krude H, Gottesdiener K, Clément K, Farooqi IS, Wiegand S, Kühnen P, Blume-Peytavi U. A Melanocortin-4 Receptor Agonist Induces Skin and Hair Pigmentation in Patients with Monogenic Mutations in the Leptin-Melanocortin Pathway. Skin Pharmacol Physiol. 2021 May 31:1-10. doi: 10.1159/000516282. PMID:34058738
Kay RG, Barker P, Burling K, Cohen M, Halsall D, Reimann F, Gribble FM, Semple RK, Church D. Increased C-Peptide Immunoreactivity in Insulin Autoimmune Syndrome (Hirata Disease) Due to High Molecular Weight Proinsulin. Clin Chem. 2021 Jun 1;67(6):854-862. doi: 10.1093/clinchem/hvab043. PMID:34051096 PMCID:PMC8167340
Kelly MP, Brayne C, Kinmonth AL, Kriznik N, Ford J, Fletcher PC. Inequalities in mental health: predictive processing and social life. Curr Opin Psychiatry. 2021 Mar 1;34(2):171-176. doi: 10.1097/YCO.0000000000000680. PMID:33394729
Kimbell B, Lawton J, Boughton C, Hovorka R, Rankin D. Parents’ experiences of caring for a young child with type 1 diabetes: a systematic review and synthesis of qualitative evidence. BMC Pediatr. 2021 Apr 4;21(1):160. doi: 10.1186/s12887-021-02569-4. PMID:33814007 PMCID:PMC8019496
Lafferty RA, Tanday N, Moffett RC, Reimann F, Gribble FM, Flatt PR, Irwin N. Positive Effects of NPY1 Receptor Activation on Islet Structure Are Driven by Pancreatic Alpha- and Beta-Cell Transdifferentiation in Diabetic Mice. Front Endocrinol (Lausanne). 2021 Feb 25;12:633625. doi: 10.3389/fendo.2021.633625. PMID:33716983 PMCID:PMC7949013
Lawton J, Hart R, Kimbell B, Allen JM, Besser REJ, Boughton C, Elleri D, Fuchs J, Ghatak A, Randell T, Thankamony A, Trevelyan N, Hovorka R, Rankin D. Data sharing whilst using a closed-loop system: Qualitative study of adolescents’ and parents’ experiences and views. Diabetes Technol Ther. 2021 Feb 19. doi: 10.1089/dia.2020.0637. PMID:33605790
Leelarathna L, Thabit H, Wilinska ME, Bally L, Mader JK, Pieber TR, Benesch C, Arnolds S, Johnson T, Heinemann L, Hermanns N, Evans ML, Hovorka R. Evaluating Glucose Control With a Novel Composite Continuous Glucose Monitoring Index. J Diabetes Sci Technol. 2020 Mar;14(2):277-283. doi: 10.1177/1932296819838525. PMID: 30931606 PMCID:PMC7196869
Li J, Zhang Y, Ye Y, Li D, Liu Y, Lee E, Zhang M, Dai X, Zhang X, Wang S, Zhang J, Jia W, Zen K, Vidal-Puig A, Jiang X, Zhang CY. Pancreatic β cells control glucose homeostasis via the secretion of exosomal miR-29 family. J Extracell Vesicles. 2021 Jan;10(3):e12055. doi: 10.1002/jev2.12055. PMID:33520119 PMCID:PMC7820156
Liu S, Marcelin G, Blouet C, Jeong JH, Jo YH, Schwartz GJ, Chua S Jr. A gut-brain axis regulating glucose metabolism mediated by bile acids and competitive fibroblast growth factor actions at the hypothalamus. Mol Metab. 2018 Feb;8:37-50. doi: 10.1016/j.molmet.2017.12.003. PMID:29290621 PMCID:PMC5985052
Lockhart SM, O’Rahilly S. Colchicine-an old dog with new tricks. Nat Metab 2021 doi:10.1038/s42255-021-00360-4.PMID: 33846642
Lotta L, Langenberg C, Wareham NJ, Farooqi IS. Reply to Unreliability of genotyping arrays for detecting very rare variants in human genetic studies: Example from a recent study of MC4R. Cell. 2021 Apr 1;184(7):1652-1653. doi: 10.1016/j.cell.2021.03.014. PMID:33798435
Lotta LA, Pietzner M, Stewart ID, Wittemans LBL, Li C, Bonelli R, Raffler J, Biggs EK, Oliver-Williams C, Auyeung VPW, Luan J, Wheeler E, Paige E, Surendran P, Michelotti GA, Scott RA, Burgess S, Zuber V, Sanderson E, Koulman A, Imamura F, Forouhi NG, Khaw KT; MacTel Consortium, Griffin JL, Wood AM, Kastenmüller G, Danesh J, Butterworth AS, Gribble FM, Reimann F, Bahlo M, Fauman E, Wareham NJ, Langenberg C. A cross-platform approach identifies genetic regulators of human metabolism and health. Nat Genet. 2021 Jan;53(1):54-64. doi: 10.1038/s41588-020-00751-5. Epub 2021 Jan 7. PMID: 33414548.
Lu VB, Gribble FM, Reimann F. Nutrient-Induced Cellular Mechanisms of Gut Hormone Secretion. Nutrients. 2021 Mar 9;13(3):883. doi: 10.3390/nu13030883. PMID:33803183 PMCID:PMC8000029
Meek CL. Swings and roundabouts: Time to rethink our approach to gestational diabetes diagnosis? Diabet Med. 2021 May 9;e14597. doi: 10.1111/dme.14597. PMID:33966291
Meek CL, Corcoy R, Asztalos E, Kusinski LC, López E, Feig DS, Murphy HR; CONCEPTT collaborative group. Which growth standards should be used to identify large- and small-for-gestational age infants of mothers with type 1 diabetes? A pre-specified analysis of the CONCEPTT trial. BMC Pregnancy Childbirth. 2021 Jan 29;21(1):96. doi: 10.1186/s12884-021-03554-6. PMID:3514342 PMCID:PMC7845036
Meek CL, Tundidor D, Feig DS, Yamamoto JM, Scott EM, Ma DD, Halperin JA, Murphy HR, Corcoy R; CONCEPTT Collaborative Group. Novel Biochemical Markers of Glycemia to Predict Pregnancy Outcomes in Women With Type 1 Diabetes. Diabetes Care. 2021 Mar;44(3):681-689. doi: 10.2337/dc20-2360. PMID:33495292 PMCID:PMC8051277
Moore SE, Doel AM, Ong KK, Dunger DB, Affara NA, Prentice AM, Bernstein RM; HERO-G Working Group. Identification of nutritionally modifiable hormonal and epigenetic drivers of positive and negative growth deviance in rural African fetuses and infants: Project protocol and cohort description. Gates Open Res. 2020 Feb 24;4:25. doi: 10.12688/gatesopenres.13101.1. PMID:33693312 PMCID:PMC7921526
Moran C, McEniery CM, Schoenmakers N, Mitchell C, Sleigh A, Watson L, Lyons G, Burling K, Barker P, Chatterjee K. Dyslipidemia, insulin resistance, ectopic lipid accumulation and vascular function in Resistance to Thyroid Hormone β. J Clin Endocrinol Metab. 2021 Feb 1:dgab002. doi: 10.1210/clinem/dgab002. PMID:33524107
Muzurović E, van der Lely AJ, Gurnell M. AST to ALT Ratio and Peripheral Arterial Disease in a Hypertensive Population-Is There a Link? Angiology. 2021 Mar 24:33197211004387. doi: 10.1177/00033197211004387. PMID:33759592
Napso T, Zhao X, Lligoña MI, Sandovici I, Kay RG, George AL, Gribble FM, Reimann F, Meek CL, Hamilton RS, Sferruzzi-Perri AN. Placental secretome characterization identifies candidates for pregnancy complications. Commun Biol. 2021 Jun 8;4(1):701. doi: 10.1038/s42003-021-02214-x. PMID:34103657 PMCID:PMC8187406
Naumenko DJ, Dykes J, O’Connor GK, Stanley Z, Affara N, Doel AM, Drammeh S, Dunger DB, Faal A, Ong KK, Sosseh F, Prentice AM, Moore SE, Bernstein RM. A Novel method for the identification and quantification of weight faltering. Am J Phys Anthropol. 2021 Jan 1. doi: 10.1002/ajpa.24217. PMID:33386624
Nizari S, Basalay M, Chapman P, Korte N, Korsak A, Christie IN, Theparambil SM, Davidson SM, Reimann F, Trapp S, Yellon DM, Gourine AV. Glucagon-like peptide-1 (GLP-1) receptor activation dilates cerebral arterioles, increases cerebral blood flow, and mediates remote (pre)conditioning neuroprotection against ischaemic stroke. Basic Res Cardiol. 2021 May 3;116(1):32. doi: 10.1007/s00395-021-00873-9. PMID:33942194 PMCID:PMC8093159
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Robertson TM, Brown JE, Fielding BA, Hovorka R, Robertson MD. Resistant Starch Production and Glucose Release from Pre-Prepared Chilled Food: The SPUD Project. Nutr Bull. 2021 Mar;46(1):52-59. doi: 10.1111/nbu.12476. PMID:33776583 PMCID:PMC7984060
Romero-Picó A, Sanchez-Rebordelo E, Imbernon M, González-Touceda D, Folgueira C, Senra A, Fernø J, Blouet C, Cabrera R, van Gestel M, Adan RA, López M, Maldonado R, Nogueiras R, Diéguez C. Melanin-Concentrating Hormone acts through hypothalamic kappa opioid system and p70S6K to stimulate acute food intake. Neuropharmacology. 2018 Mar 1;130:62-70. doi: 10.1016/j.neuropharm.2017.11.040. PMID:29191753
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2020

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Araiz C, Yan A, Bettedi L, Samuelson I, Virtue S, McGavigan AK, Dani C, Vidal-Puig A, Foukas LC. Publisher Correction: Enhanced β-Adrenergic Signalling Underlies an Age-Dependent Beneficial Metabolic Effect of PI3K p110α Inactivation in Adipose Tissue. Nat Commun. 2020 Feb 21;11(1):1078. PMID: 32081871.
Ast J, Arvaniti A, Fine NHF, Nasteska D, Ashford FB, Stamataki Z, Koszegi Z, Bacon A, Jones BJ, Lucey MA, Sasaki S, Brierley DI, Hastoy B, Tomas A, D’Agostino G, Reimann F, Lynn FC, Reissaus CA, Linnemann AK, D’Este E, Calebiro D, Trapp S, Johnsson K, Podewin T, Broichha- gen J, Hodson DJ. Author Correction: Super-resolution microscopy compatible fluorescent probes reveal endogenous glucagon-like peptide-1 receptor distribution and dynamics. Nat Commun. 2020 Oct 9;11(1):5160. PMID: 33037231.
Azzu V, Vacca M, Virtue S, Allison M, Vidal-Puig A. Adipose tissue-liver cross talk in the control of whole-body metabolism: implications in non-alcoholic fatty liver disease. Gastroenterology. 2020 Feb 12. pii: S0016-5085(20)30224-9. Epub ahead of print. PMID: 32061598.
Baig S, Shabeer M, Parvaresh Rizi E, Agarwal M, Lee MH, Ooi DSQ, Chia C, Aung N, Ng G, Teo Y, Chhay V, Magkos F, Vidal-Puig A, Seet RCS, Toh SA. Heredity of type 2 diabetes confers increased susceptibility to oxidative stress and inflammation. BMJ Open Diabetes Res Care. 2020 Jan;8(1). PMID: 32049633. PMCID: PMC7039582.
Banholzer N, Herzig D, Piazza C, Álvarez-Martínez M, Nakas CT, Kosinski C, Feuerriegel S, Hovorka R, Bally L. Effect of nutrition on postprandial glucose control in hospitalized patients with type 2 diabetes receiving fully automated closed-loop insulin therapy. Diabetes Obes Metab. 2020 Sep 4. PMID: 32885596.
Bashari WA, Senanayake R, Koulouri O, Gillett D, MacFarlane J, Powlson AS, FernandezPombo A, Bano G, Martin AJ, Scoffings D, Cheow H, Mendichovszky I, Tysome J, Donnelly N, Santarius T, Kolias A, Mannion R, Gurnell M. PET-guided Repeat Transsphenoidal Surgery for Previously Deemed Unresectable Lateral Disease in Acromegaly. Neurosurgical Focus. 2020 Jun;48(6):E8. PMID: 32480379.
Bernstein RM, O’Connor GK, Vance EA, Affara N, Drammeh S, Dunger DB, Faal A, Ong KK, Sosseh F, Prentice AM, Moore SE. Timing of the Infancy-Childhood Growth Transition in Rural Gambia. Frontiers of Endocrinology (Lausanne). 2020 Mar 24;11:142. PMID: 32265838 PMCID: PMC7105771.
Blackwell AKM, De-Loyde K, Brocklebank LA, Maynard OM, Marteau TM, Hollands GJ, Fletcher PC, Attwood AS, Morris RW, Munafò MR. Tobacco and electronic cigarette cues for smoking and vaping: an online experimental study. BMC Res Notes. 2020 Jan 15;13(1):32. PubMed PMID:31941548; PubMed Central PMCID: PMC6964108.
Blackwell AKM, De-Loyde K, Hollands GJ, Morris RW, Brocklebank LA, Maynard OM, Fletcher PC, Marteau TM, Munafò MR. The Impact on Selection of Non-Alcoholic vs Alcoholic Drink Availability: An Online Experiment. BMC Public Health. 2020 May 6;20(1):526. PMID: 32370760 PMCID: PMC7201696.
Blastland M, Freeman ALJ, van der Linden S, Marteau TM, Spiegelhalter D. Five rules for evidence communication. Nature. 2020 Nov;587(7834):362-364. doi: 10.1038/d41586-020-03189-1. PMID: 33208954.
Boughton C, Allen JM, Tauschmann M, Hartnell S, Wilinska ME, Musolino G, Acerini CL, Dunger PD, Campbell F, Ghatak A, Randell T, Besser R, Trevelyan N, Elleri D, Northam E, Hood K, Scott E, Lawton J, Roze S, Sibayan J, Kollman C, Cohen N, Todd J, Hovorka R; CLOuD Consortium. Assessing the effect of closed-loop insulin delivery from onset of type 1 diabetes in youth on residual beta-cell function compared to standard insulin therapy (CLOuD study): a randomised parallel study protocol. BMJ Open. 2020 Mar 12;10(3):e033500. PMID: 32169925; PMCID: PMC7069267.
Boughton CK, Hartnell S, Allen JM, Fuchs J, Hovorka R. Training and Support for Hybrid Closed -Loop Therapy. J Diabetes Sci Technol. 2020 Sep 11;1932296820955168. PMID: 32914648.
Boughton CK, Hovorka R. The artificial pancreas. Curr Opin Organ Transplant. 2020 Aug;25 (4):336-342. PMID: 32618719.
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Burton NO, Riccio C, Dallaire A, Price J, Jenkins B, Koulman A, Miska EA. Cysteine Synthases CYSL-1 and CYSL-2 Mediate C. Elegans Heritable Adaptation to P. Vranovensis Infection. Nature Communications. 2020 Apr 8;11(1):1741. PMID: 32269224 PMCID: PMC7142082.
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Campi I, Covelli D, Moran C, Fugazzola L, Cacciatore C, Orlandi F, Gallone G, Chatterjee K, Beck-Peccoz P, Persani L. The Differential Diagnosis of Discrepant Thyroid Function Tests: Insistent Pitfalls and Updated Flow-Chart Based on a Long-Standing Experience. Front Endocrinol (Lausanne) 2020 Jul 7;11:432. PMID: 32733382. PMC7358450.
Chae H, Augustin R, Gatineau E, Mayoux E, Bensellam M, Antoine N, Khattab F, Lai BK, Brusa D, Stierstorfer B, Klein H, Singh B, Ruiz L, Pieper M, Mark M, Herrera PL, Gribble FM, Reimann F, Wojtusciszyn A, Broca C, Rita N, Piemonti L, Gilon P. SGLT2 is not expressed in pancreatic α – and β-cells, and its inhibition does not directly affect glucagon and insulin secretion in rodents and humans. Mol Metab. 2020 Sep 5;42:101071. PMID: 32896668.
Chalmers J, Tung YCL, Liu CH, O’Kane CJ, O’Rahilly S, Yeo GSH. A multi-component screen for feeding behaviour and nutritional status in Drosophila to interrogate mammalian appetite-related genes. Mol Metab
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Cheng W, Gonzalez I, Pan W, Tsang A H, Adams J, Nkoda E, Gordian D, Khoury B, Roelofs K, Evers S, MacKinnon A, Wu S, Frikke-Schmidt H, Flak J N, Trevaskis J L, Rhodes C J, Fukada S, Seeley R J, Sandoval D A, Olson D P, Blouet C, and Myers, Jr M G. Calcitonin Receptor Neurons in the Mouse Nucleus Tractus Solitarius Control Energy Balance via the non-Aversive Suppression of Feeding. Cell Metab. 2020 Feb 4;31(2):301-312.e5. PubMed PMID: 31955990.
Chiesa ST, Marcovecchio ML, Benitez-Aguirre P, Cameron FJ, Craig ME, Couper JJ, Davis EA, Dalton RN, Daneman D, Donaghue KC, Jones TW, Mahmud FH, Marshall SM, Neil HAW, Dunger DB, Deanfield JE; Adolescent Type 1 Diabetes Cardio-Renal Intervention Trial (AdDIT) Study Group. Vascular Effects of ACE (Angiotensin-Converting Enzyme) Inhibitors and Statins in Adolescents With Type 1 Diabetes. Hypertension. 2020 Dec;76(6):1734-1743. doi: 10.1161/HYPERTENSIONAHA.120.15721. PMID: 33100044.
Clarke N, Pechey E, Mantzari E, Blackwell AKM, De-Loyde K, Morris RW, Munafò MR, Marteau TM, Hollands GJ. Impact of Health Warning Labels Communicating the Risk of Cancer on Alcohol Selection: An Online Experimental Study. Addiction. 2020 Apr 8. PMID: 32267588.
Clément K, van den Akker E, Argente J, Bahm A, Chung WK, Connors H, De Waele K, Farooqi IS, Gonneau-Lejeune J, Gordon G, Kohlsdorf K, Poitou C, Puder L, Swain J, Stewart M, Yuan G, Wabitsch M, Kühnen P; Setmelanotide POMC and LEPR Phase 3 Trial Investigators. Efficacy and safety of setmelanotide, an MC4R agonist, in individuals with severe obesity due to LEPR or POMC deficiency: single-arm, open-label, multicentre, phase 3 trials. Lancet Diabetes Endocrinol. 2020 Dec;8(12):960-970. doi: 10.1016/S2213-8587(20)30364-8. PMID: 33137293.
Coll AP, Chen M, Taskar P, Rimmington D, Patel S, Tadross JA, Cimino I, Yang M, Welsh P, Virtue S, Goldspink DA, Miedzybrodzka EL, Konopka AR, Esponda RR, Huang JT, Tung YCL, Rodriguez-Cuenca S, Tomaz RA, Harding HP, Melvin A, Yeo GSH, Preiss D, Vidal-Puig A, Vallier L, Nair KS, Wareham NJ, Ron D, Gribble FM, Reimann F, Sattar N, Savage DB, Allan BB, O’Rahilly S. Publisher Correction: GDF15 mediates the effects of metformin on body weight and energy balance. Nature. 2020 Feb;578(7796):E24. PMID: 32051582.
Colombo M, McGurnaghan SJ, Blackbourn LAK, Dalton RN, Dunger D, Bell S, Petrie JR, Green F, MacRury S, McKnight JA, Chalmers J, Collier A, McKeigue PM, Colhoun HM; Scottish Diabetes Research Network (SDRN) Type 1 Bioresource Investigators. Comparison of Serum and Urinary Biomarker Panels With Albumin/Creatinine Ratio in the Prediction of Renal Function Decline in Type 1 Diabetes. Diabetologia. 2020 Apr;63(4):788-798. PMID: 31915892 PMCID: PMC7054370.
Crabtree DR, Buosi W, Fyfe CL, Horgan GW, Manios Y, Androutsos O, Giannopoulou A, Finlayson G, Beaulieu K, Meek CL, Holst JJ, Van Norren KV, Mercer JG, Johnstone AM. Appetite Control across the Lifecourse: The Acute Impact of Breakfast Drink Quantity and Protein Content. The Full4Health Project. Nutrients. 2020 Nov 30;12(12):3710. doi: 10.3390/nu12123710. PMID:33266325 PMCID:PMC7759987
de Almeida-Faria J, Duque-Guimarães DE 1, Ong TP, Pantaleão LC, Carpenter AA, Loche E, Kusinski LC, Ashmore TJ, Antrobus R, Bushell M, Fernandez-Twinn DS, Ozanne SE. Maternal obesity during pregnancy leads to adipose tissue ER stress in mice via miR-126-mediated reduction in Lunapark. Diabetologia.
Dearden L, Buller S, Furigo IC, Fernandez-Twinn DS, Ozanne SE. Maternal obesity causes fetal hypothalamic insulin resistance and disrupts development of hypothalamic feeding pathways. Mol Metab. 2020 Sep 9;42:101079. PMID: 32919096 PMC7549144.
de Barros Mucci D, Kusinski LC, Wilsmore P, Loche E, Pantaleão LC, Ashmore TJ, Blackmore HL, Fernandez-Twinn DS, Carmo MDGTD, Ozanne SE. Impact of maternal obesity on placental transcriptome and morphology associated with fetal growth restriction in mice. Int J Obes (Lond). 2020 Mar 13. PMID:32203108.
Diederen KMJ, Fletcher PC. Dopamine, Prediction Error and Beyond. Neuroscientist. 2020 Apr 26:1073858420907591. PMID: 32338128.
Fisher BG, Thankamony A, Mendiola J, Petry CJ, Frederiksen H, Andersson AM, Juul A, Ong KK, Dunger DB, Hughes IA, Acerini CL. Maternal Serum Concentrations of Bisphenol A and Propyl Paraben in Early Pregnancy Are Associated With Male Infant Genital Development. Human Reproduction. 2020 Apr 28;35(4):913-928. PMID: 32325494.
Fleseriu M, Buchfelder M, Cetas JS, Fazeli PK, Mallea-Gil SM, Gurnell M, McCormack A, Pineyro MM, Syro LV, Tritos NA, Marcus HJ. Pituitary society guidance: pituitary disease management and patient care recommendations during the COVID-19 pandemic-an international perspective. Pituitary. 2020 Aug;23(4):327-337. PMID: 32556793. PMC7300368.
Fuchs J, Hovorka R. Closed-loop control in insulin pumps for type-1 diabetes mellitus: safety and efficacy. Expert Rev Med Devices. 2020 Jul 3;1-14. PMID: 32569476.
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2019

Adriaensses A; Gribble FM; Reimann F. The glucose-dependent insulinotropic polypeptide signalling axis in the central nervous system. Peptides. 2020 Mar;125:170194. Epub 2019 Nov 4. Review. PMID: 31697967
Adriaenssens AE, Biggs EK, Darwish T, Tadross J, Sukthankar T, Girish M, Polex-Wolf J, Lam BY, Zvetkova I, Pan W, Chiarugi D, Yeo GSH, Blouet C, Gribble FM, Reimann F. GlucoseDependent Insulinotropic Polypeptide Receptor-Expressing Cells in the Hypothalamus Regulate Food Intake. Cell Metab. 2019 Aug 19. [Epub ahead of print] PMID: 31447324.
Ahmed RM, Landin-Romero R, Liang CT, Keogh JM, Henning E, Strikwerda-Brown C, Devenney EM, Hodges JR, Kiernan MC, Farooqi IS, Piguet O. Neural networks associated with body composition in frontotemporal dementia. Ann Clin Transl Neurol. 2019 Sep;6(9):1707-1717. PMID: 31461580.
Aiken CEM, Hone L, Murphy HR, Meek CL. Improving outcomes in gestational diabetes: does gestational weight gain matter? Diabet Med. 2019 Feb;36(2):167-176. doi: 10.1111/dme.13767. PMID:29932243
Aiken CE, Tarry-Adkins JL, Ashmore TJ, Ozanne SE. Early life environment influences the trajectory of post-partum weight loss in adult female rats. Reprod Biomed Online. 2019 May;38(5):779-786. doi: 10.1016/j.rbmo.2018.12.002. Epub 2018 Dec 12. PMID: 30885667. PMCID: PMC6491499
Aiken CE, Tarry-Adkins JL, Ozanne SE. Assaying Reproductive Capacity in Female Rodents. Methods Mol Biol.
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Aiken CE, Tarry-Adkins JL, Spiroski AM, Nuzzo AM, Ashmore TJ, Rolfo A, Sutherland MJ, Camm EJ, Giussani DA, Ozanne SE. Chronic fetal hypoxia disrupts the peri-conceptual environment in nextgeneration adult female rats. J Physiol. 2019 May;597(9):2391-2401. doi: 10.1113/JP277431. Epub 2019 Mar 24. PMID: 30791124 PMCID: PMC6487938
Aiken CE, Tarry-Adkins JL, Spiroski AM, Nuzzo AM, Ashmore TJ, Rolfo A, Sutherland MJ, Camm EJ, Giussani DA, Ozanne SE. Chronic gestational hypoxia accelerates ovarian aging and lowers ovarian reserve in next-generation adult rats. FASEB J. 2019 Jun;33(6):7758-7766. doi: 10.1096/fj.201802772R. Epub 2019 Mar 19. PMID: 30888848 PMCID: PMC6529349
Ajjaji D, Ben M’barek K, Mimmack ML, England C, Herscovitz H, Dong L, Kay RG, Patel S, Saudek V, Small DM, Savage DB, Thiam AR. Dual binding motifs underpin the hierarchical association of perilipins1 -3 with lipid droplets. Mol Biol Cell. 2019 Mar 1;30(5):703-716. doi: 10.1091/mbc.E18-08-0534. Epub 2019 Jan 16. PMID: 30649995 PMCID: PMC6589688
Al-Massadi O, Quiñones M, Clasadonte J, Hernandez-Bautista R, Romero-Picó A, Folgueira C, Morgan DA, Kalló I, Heras V, Senra A, Funderburk SC, Krashes MJ, Souto Y, Fidalgo M, Luquet S, Chee MJ, Imbernon M, Beiroa D, García-Caballero L, Gallego R, Lam BYH, Yeo G, Lopez M, Liposits Z, Rahmouni K, Prevot V, Dieguez C, Nogueiras R. MCH Regulates SIRT1/FoxO1 and Reduces POMC Neuronal Activity to Induce Hyperphagia, Adiposity, and Glucose Intolerance. Diabetes. 2019 Dec;68(12):2210-2222. Epub 2019 Sep 16. PubMed PMID:31530579; PubMed Central PMCID: PMC6868473.
Araiz C, Yan A, Bettedi L, Samuelson I, Virtue S, McGavigan AK, Dani C, Vidal-Puig A, Foukas LC. Enhanced β-adrenergic signalling underlies an age-dependent beneficial metabolic effect of PI3K p110α inactivation in adipose tissue. Nat Commun. 2019 Apr 4;10(1):1546. PMID:30948720
Ast J, Arvaniti A, Fine NHF, Nasteska D, Ashford FB, Stamataki Z, Koszegi Z, Bacon A, Jones BJ, Lucey MA, Sasaki S, Brierley DI, Hastoy B, Tomas A, D’Agostino G, Reimann F, Lynn FC, Reissaus CA, Linnemann AK, D’Este E, Calebiro D, Trapp S, Johnsson K, Podewin T, Broichhagen J, Hodson DJ. Super-resolution microscopy compatible fluorescent probes reveal endogenous glucagon-like peptide-1 receptor distribution and dynamics. Nat Commun. 2020 Jan 24;11 (1):467. PubMed PMID: 31980626; PubMed Central PMCID: PMC6981144.
Badenes M, Amin A, González-García I, Félix I, Burbridge E, Cavadas M, Ortega FJ, de Carvalho É, Faísca P, Carobbio S, Seixas E, Pedroso D, Neves-Costa A, Moita LF, Fernández-Real JM, Vidal-Puig A, Domingos A, López M, Adrain C. Deletion of iRhom2 protects against dietinduced obesity by increasing thermogenesis. Mol Metab. 2020 Jan;31:67-84.Epub 2019 Oct 31. PubMed PMID: 31918923; PubMed Central PMCID: PMC6909339.
Baig S, Parvaresh Rizi E, Chia C, Shabeer M, Aung N, Loh TP, Magkos F, Vidal-Puig A, Seet RCS, Khoo CM, Toh SA. Genes Involved in Oxidative Stress Pathways Are Differentially Expressed in Circulating Mononuclear Cells Derived From Obese Insulin-Resistant and Lean Insulin-Sensitive Individuals Following a Single Mixed-Meal Challenge. Front Endocrinol (Lausanne). 2019 Apr 24;10:256. eCollection 2019. PMID:31068904 PubMed Central PMCID:PMC6491694
Bally L, Gubler P, Thabit H, Hartnell S, Ruan Y, Wilinska ME, Evans ML, Semmo M, Vogt B, Coll AP, Stettler C, Hovorka R. Fully closed-loop insulin delivery improves glucose control of inpatients with type 2 diabetes receiving hemodialysis. Kidney Int. 2019 Sep;96(3):593-596. PMID: 31133457.
Bally L, Herzig D, Ruan Y, Wilinska ME, Semmo M, Vogt A, Wertli MM, Vogt B, Stettler C, Hovorka R. Short-term fully closed-loop insulin delivery using faster insulin aspart compared with standard insulin aspart in type 2 diabetes. Diabetes Obes Metab. 2019 Aug 28. [Epub ahead of print] PMID: 31464063.
Barbosa AD, Lim K, Mari M, Edgar JR, Gal L, Sterk P, Jenkins BJ, Koulman A, Savage DB, Schuldiner M, Reggiori F, Wigge PA, Siniossoglou S. Compartmentalized Synthesis of Triacylglycerol at the Inner Nuclear Membrane Regulates Nuclear Organization. Dev Cell. 2019 Sep 23;50(6):755-766.e6. PMID: 31422915.
Bariana TK, Labarque V, Heremans J, Thys C, De Reys M, Greene D, Jenkins B, Grassi L, Seyres D, Burden F, Whitehorn D, Shamardina O, Papadia S, Gomez K, BioResource N, Van Geet C, Koulman A, Ouwehand WH, Ghevaert C, Frontini M, Turro E, Freson K. Sphingolipid dysregulation due to lack of functional KDSR impairs proplatelet formation causing thrombocytopenia. Haematologica. 2019 May;104(5):1036-1045. Epub 2018 Nov 22. PMID:30467204 PubMed Central PMCID:PMC6518879
Bashari WA, Senanayake R, Fernández-Pombo A, Gillett D, Koulouri O, Powlson AS, Matys T, Scoffings D, Cheow H, Mendichovszky I, Gurnell M. Modern imaging of pituitary adenomas. Best Pract Res Clin Endocrinol Metab. 2019 May 28. [Epub ahead of print] Review. PMID:31208872
Battelino T, Danne T, Bergenstal RM, Amiel SA, Beck R, Biester T, Bosi E, Buckingham BA, Cefalu WT, Close KL, Cobelli C, Dassau E, DeVries JH, Donaghue KC, Dovc K, Doyle FJ 3rd, Garg S, Grunberger G, Heller S, Heinemann L, Hirsch IB, Hovorka R, Jia W, Kordonouri O, Kovatchev B, Kowalski A, Laffel L, Levine B, Mayorov A, Mathieu C, Murphy HR, Nimri R, Nørgaard K, Parkin CG, Renard E, Rodbard D, Saboo B, Schatz D, Stoner K, Urakami T, Weinzimer SA, Phillip M. Clinical Targets for Continuous Glucose Monitoring Data Interpretation: Recommendations From the International Consensus on Time in Range. Diabetes Care. 2019 Aug;42(8):1593-1603. Epub 2019 Jun 8. Review. PMID:31177185 PubMed Central PMCID:PMC6973648
Beardsall K, Thomson L, Elleri D, Dunger DB, Hovorka R. Feasibility of automated insulin delivery guided by continuous glucose monitoring in preterm infants. Arch Dis Child Fetal Neonatal Ed. 2019 Aug 9. pii: fetalneonatal-2019-316871. [Epub ahead of print] PMID: 31399480.
Biancolin AD, Martchenko A, Mitova E, Gurges P, Michalchyshyn E, Chalmers JA, Doria A, Mychaleckyj JC, Adriaenssens AE, Reimann F, Gribble FM, Gil-Lozano M, Cox BJ, Brubaker PL. The core clock gene, Bmal1, and its downstream target, the SNARE regulatory protein secretagogin, are necessary for circadian secretion of glucagon-like peptide-1. Mol Metab. 2020 Jan;31:124-137. Epub 2019 Nov 21. PubMed PMID: 31918914; PubMed Central PMCID: PMC6920326.
Boughton CK, Bally L, Hartnell S, Wilinska M, Coll AP, Evans M, Stettler C, Hovorka R. Closedloop insulin delivery in end-of-life care: a case report. Diabet Med. 2019 Apr 19. [Epub ahead of print] PMID: 31002426.
Boughton CK, Bally L, Hovorka R. Closed-loop management of inpatient hyperglycemia. Aging (Albany NY). 2019 Aug 8;11(15):5292-5293. PMID: 31395790
Boughton CK, Bally L, Martignoni F, Hartnell S, Herzig D, Vogt A, Wertli MM, Wilinska ME, Evans ML, Coll AP, Stettler C, Hovorka R. Fully closed-loop insulin delivery in inpatients receiving nutritional support: a two-centre, open-label, randomised controlled trial. Lancet Diabetes Endocrinol. 2019 May;7(5):368-377. Epub 2019 Mar 29. PMID:30935872 PubMed Central PMCID:PMC6467839
Boughton CK, Hartnell S, Allen JM, Hovorka R. The importance of prandial insulin bolus timing with hybrid closed-loop systems. Diabet Med. 2019 Aug 23. [Epub ahead of print] PMID: 31441093.
Boughton CK, Hovorka R. Advances in artificial pancreas systems. Sci Transl Med. 2019 Mar 20;11(484):eaaw4949. doi: 10.1126/scitranslmed.aaw4949. PMID: 30894501
Broekema MF, Savage DB, Monajemi H, Kalkhoven E. Gene-gene and gene-environment interactions in lipodystrophy: Lessons learned from natural PPARγ mutants. Biochim Biophys Acta Mol Cell Biol Lipids. 2019 May;1864(5):715-732. Review. PMID: 30742913
Chiesa ST, Charakida M, McLoughlin E, Nguyen HC, Georgiopoulos G, Motran L, Elia Y, Marcovecchio ML, Dunger DB, Dalton RN, Daneman D, Sochett E, Mahmud FH, Deanfield JE. Elevated high-density lipoprotein in adolescents with Type 1 diabetes is associated with endothelial dysfunction in the presence of systemic inflammation. Eur Heart J. 2019 Nov 14;40(43):3559-3566. doi: 10.1093/eurheartj/ehz114. PMID: 30863865 PMCID: PMC6855140
Clément M, Raffort J, Lareyre F, Tsiantoulas D, Newland SA, Lu Y, Masters L, Harrison J, Saveljeva S, Ma MK, Ozsvar-Kozma M, Lam B, Yeo GS, Binder CJ, Kaser A, Mallat Z. Impaired Autophagy in CD11b(+) Dendritic Cells Expands CD4(+) Regulatory T Cells And Limits Atherosclerosis in Mice. Circ Res. 2019 Oct 15. [Epub ahead of print] PMID: 31610723.
Coll AP, Chen M, Taskar P, Rimmington D, Patel S, Tadross J, Cimino I, Tung YCL, Miedzybrodzka E, Welsh P, Virtue S, Rodriguez-Cuenca S, Yang M, Goldspink DA, Tomaz RA, Harding HP, Melvin A, Yeo GSH, Preiss D, Vidal-Puig A, Vallier L, Ron D, Gribble FM, Reimann F, Sattar N, Savage DB, Allan BB, O’Rahilly S. GDF15 and the beneficial actions of metformin in pre-diabetes. Nature. 2019 Dec 25. Epub ahead of print PMID: 31875646.
Colombo M, Valo E, McGurnaghan SJ, Sandholm N, Blackbourn LAK, Dalton RN, Dunger D, Groop PH, McKeigue PM, Forsblom C, Colhoun HM; FinnDiane Study Group and the Scottish Diabetes Research Network (SDRN) Type 1 Bioresource Collaboration. Biomarker panels associated with progression of renal disease in type 1 diabetes. Diabetologia. 2019 Jun 20. [Epub ahead of print] PMID:31222504; PubMed Central ID: PMC6677704
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Peters C, Nicholas AK, Schoenmakers E, Lyons G, Langham S, Serra EG, Sebire NJ, Muzza M, Fugazzola L, Schoenmakers N. DUOX2/DUOXA2 Mutations Frequently Cause Congenital Hypothyroidism that Evades Detection on Newborn Screening in the United Kingdom. Thyroid. 2019 Jun;29(6):790-801. PMID:31044655; PMCID:PMC6588112
Petkevicius K, Virtue S, Bidault G, Jenkins B, Çubuk C, Morgantini C, Aouadi M, Dopazo J, Serlie MJ, Koulman A, Vidal-Puig A. Accelerated phosphatidylcholine turnover in macrophages promotes adipose tissue inflammation in obesity. Elife. 2019 Aug 16;8. PMID: 31418690.
Petry CJ, Ong KK, Hughes IA, Acerini CL, Dunger DB. Age at Menarche and Blood Pressure in Pregnancy. Pregnancy Hypertens. 2019 Jan;15:134-140. PMID: 30713829 PMCID: PMC6352955
Prats-Puig A, Xargay-Torrent S, Carreras-Badosa G, Mas-Parés B, Bassols J, Petry CJ, Girardot M, D E Zegher F, Ibáñez L, Dunger DB, Feil R, López-Bermejo A. Methylation of the C19MC microRNA locus in the placenta: association with maternal and chilhood body size. Int J Obes (Lond). 2019 Sep 25. [Epub ahead of print] PMID: 31554916.
Prentice PM, Olga L, Petry CJ, Simmons D, Murphy HR, Hughes IA, Acerini CL, Ong KK, Dunger DB. Reduced size at birth and persisting reductions in adiposity in recent, compared with earlier, cohorts of infants born to mothers with gestational diabetes mellitus. Diabetologia. 2019 Nov;62(11):1977-1987. Epub 2019 Aug 9. PubMed PMID: 31396660; PubMed Central PMCID: 6805804.
Prentice PM, Schoemaker MH, Vervoort J, Hettinga K, Lambers TT, van Tol EAF, Acerini CL, Olga L, Petry CJ, Hughes IA, Koulman A, Ong KK, Dunger DB. Human Milk Short-Chain Fatty Acid Composition is Associated with Adiposity Outcomes in Infants. J Nutr. 2019 May 1;149(5):716-722. PMID:31050748
Rana BMJ, Jou E, Barlow JL, Rodriguez-Rodriguez N, Walker JA, Knox C, Jolin HE, Hardman CS, Sivasubramaniam M, Szeto A, Cohen ES, Scott IC, Sleeman MA, Chidomere CI, Cruz Migoni S, Caamano J, Jorgensen HF, Carobbio S, Vidal-Puig A, McKenzie ANJ. A stromal cell niche sustains ILC2-mediated type-2 conditioning in adipose tissue. J Exp Med. 2019 Sep 2;216 (9):1999-2009. PMID: 31248899.
Razolli D, de Araújo T, Sant’Ana M, Kirwan P, Cintra D, Merkle F, Velloso L. POMC processing in the hypothalamus is directly regulated by saturated fat – implications for the development of obesity. Neuroendocrinology. 2019 May 20. [Epub ahead of print]. PMID: 31104058
Reimann F; Diakogiannaki E; Moss C E; Gribble F M. Cellular mechanisms governing Glucosedependent insulinotropic polypeptide secretion. Peptides. 2020 Mar;125:170206 170206. Epub 2019 Nov 19. Review. PubMed PMID: 31756367.
Riveros-McKay F, Mistry V, Bounds R, Hendricks A, Keogh JM, Thomas H, Henning E, Corbin LJ; Understanding Society Scientific Group, O’Rahilly S, Zeggini E, Wheeler E, Barroso I, Farooqi IS. Genetic architecture of human thinness compared to severe obesity. PLoS Genet. 2019 Jan 24;15(1):e1007603. PMID: 30677029 PMCID: PMC6345421
Roberts GP, Larraufie P, Richards P, Kay RG, Galvin SG, Miedzybrodzka EL, Leiter A, Li HJ, Glass LL, Ma MKL, Lam B, Yeo GSH, Scharfmann R, Chiarugi D, Hardwick RH, Reimann F, Gribble FM. Comparison of Human and Murine Enteroendocrine Cells by Transcriptomic and Peptidomic Profiling. Diabetes. 2019 May;68(5):1062-1072. doi: 10.2337/db18-0883. Epub 2019 Feb 7. PMID: 30733330 PMCID: PMC6477899
Ronan L, Alexander-Bloch A, Fletcher PC. Childhood Obesity, Cortical Structure, and Executive Function in Healthy Children. Cereb Cortex. 2019 Oct 24. [Epub ahead of print] PMID: 31646343.
Ruan Y, Willemsen RH, Wilinska ME, Tauschmann M, Dunger DB, Hovorka R. Mixed-meal tolerance test to assess residual beta-cell secretion: Beyond the area-under-curve of plasma C-peptide concentration. Pediatr Diabetes. 2019 May;20(3):282-285. doi: 10.1111/pedi.12816. PMID: 30652426 PMCID: PMC6487945
Savage DB, Watson L, Carr K, Adams C, Brage S, Chatterjee KK, Hodson L, Boesch C, Kemp GJ, Sleigh A. Accumulation of saturated intramyocellular lipid is associated with insulin resistance. J. Lipid Res. (2019) Jul;60(7):1323-1332. Epub 2019 May 2. PMID:31048405; PMCID:PMC6602127
Sefton C, Davies A, Allen TJ, Wray JR, Shoop R, Adamson A, Humphreys N, Coll AP, White A, Harno E. The metabolic abnormalities of chronic high dose glucocorticoids are not mediated by hypothalamic AgRP in male mice. Endocrinology. 2019 May 1;160(5):964-978. doi: 10.1210/en.2019-00018. PMID: 30794724 PMCID: PMC6444294
Schierloh U, Wilinska ME, Pit-Ten Cate IM, Baumann P, Hovorka R, De Beaufort C; Spidiman Study Group: Single Port Insulin Infusion for Improved Diabetes Management. Lower plasma insulin levels during overnight closed-loop in school children with type 1 diabetes: Potential advantage? A randomized cross-over trial. PLoS One. 2019 Mar 8;14(3):e0212013. doi: 10.1371/journal.pone.0212013. eCollection 2019. PMID: 30849076 PMCID: PMC6408001
Speight J, Holmes-Truscott E, Little SA, Leelarathna L, Walkinshaw E, Tan HK, Bowes A, Kerr D, Flanagan D, Heller SR, Evans ML, Shaw JAM. Satisfaction with the Use of Different Technologies for Insulin Delivery and Glucose Monitoring Among Adults with Long-Standing Type 1 Diabetes and Problematic Hypoglycemia: 2-Year Follow-Up in the HypoCOMPaSS Randomized Clinical Trial. Diabetes Technol Ther. 2019 Nov;21(11):619-626. PMID: 31335201.
Sutherland MJ, Camm EJ, Giussani DA, Ozanne SE. Chronic gestational hypoxia accelerates ovarian aging and lowers ovarian reserve in next-generation adult rats. FASEB J. 2019 Jun;33 (6):7758-7766. Epub 2019 Mar 19. PMID:30888848; PMCID:PMC6529349
Tarry-Adkins JL, Aiken CE, Ozanne SE. Neonatal, infant, and childhood growth following metformin versus insulin treatment for gestational diabetes: A systematic review and meta-analysis. PLoS Med. 2019 Aug 6;16(8):e1002848. PMID: 31386659.
Tarry-Adkins JL, Ozanne SE. Poor Early Growth and Age-Associated Disease. Subcell Biochem. 2019;91:1-19. PMID: 30888647
Tauschmann M, Allen JM, Nagl K, Fritsch M, Yong J, Metcalfe E, Schaeffer D, Fichelle M, Schierloh U, Thiele AG, Abt D, Kojzar H, Mader JK, Slegtenhorst S, Barber N, Wilinska ME, Boughton C, Musolino G, Sibayan J, Cohen N, Kollman C, Hofer SE, Fröhlich-Reiterer E, Kapellen TM, Acerini CL, de Beaufort C, Campbell F, Rami-Merhar B, Hovorka R; KidsAP Consortium. Home Use of Day-and-Night Hybrid Closed-Loop Insulin Delivery in Very Young Children: A Multicenter, 3-Week, Randomized Trial. Diabetes Care. 2019 Apr;42(4):594-600. doi: 10.2337/dc18-1881. Epub 2019 Jan 28. PMID: 30692242
Teulings NEWD, Masconi KL, Ozanne SE, Aiken CE, Wood AM. Effect of interpregnancy weight change on perinatal outcomes: systematic review and meta-analysis. BMC Pregnancy Childbirth. 2019 Oct 28;19(1):386. PMID: 31660893.
Thakar R, Gajewska-Knapik G, Ogilvy-Stuart AL, Chatterjee K, Moran C. Response to Letter to the Editor: “Alemtuzumab-induced thyroid dysfunction exhibits distinctive clinical and immunological features”. J.Clin. Endocrinol. Metab. (2019). PMID:30977836
Tschaikner M, Powell K, Jungklaus M, Fritz M, Ellmerer M, Hovorka R, Lane S, Pieber TR, Regittnig W. Novel Single-Site Device for Conjoined Glucose Sensing and Insulin Infusion: Performance Evaluation in Diabetes Patients During Home-Use. IEEE Trans Biomed Eng. 2019 Jun 27. [Epub ahead of print]. PMID:31251175
Turcot V, 39 authors, Barroso I, 65 authors, Farooqi IS, 293 authors, Loos RJF. Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity. Nat Genet. 2019 Jul;51(7):1191- 1192. PMID:31160809
van der Klaauw AA, Croizier S, Mendes de Oliveira E, Stadler LKJ, Park S, Kong Y, Banton MC, Tandon P, Hendricks AE, Keogh JM, Riley SE, Papadia S, Henning E, Bounds R, Bochukova EG, Mistry V, O’Rahilly S, Simerly RB; INTERVAL; UK10K Consortium, Minchin JEN, Barroso I, Jones EY, Bouret SG, Farooqi IS. Human Semaphorin 3 Variants Link Melanocortin Circuit Development and Energy Balance. Cell. 2019 Feb 7;176(4):729-742.e18. PMID: 30661757 PMCID: PMC6370916
Vargas-Castillo A, Tobon-Cornejo S, Del Valle-Mondragon L, Torre-Villalvazo I, SchcolnikCabrera A, Guevara-Cruz M, Pichardo-Ontiveros E, Fuentes-Romero R,Bader M, Alenina N, Vidal-Puig A, Hong E, Torres N, Tovar AR. Angiotensin-(1-7) induces beige fat thermogenesis through the Mas receptor. Metabolism. 2019 Dec 13;103:154048. Epub ahead of print. PubMed PMID: 31843339. PMCID: PMC7054746.
Vasiljevic M, Fuller G, Pilling M, Hollands GJ, Pechey R, Jebb SA, Marteau TM. What is the impact of increasing the prominence of calorie labelling? A stepped wedge randomised controlled pilot trial in worksite cafeterias. Appetite. 2019 Oct 1;141:104304. Epub 2019 May 29. PMID:31152762
Vergari E, Knudsen JG, Ramracheya R, Salehi A, Zhang Q, Adam J, Asterholm IW, Benrick A, Briant LJB, Chibalina MV, Gribble FM, Hamilton A, Hastoy B, Reimann F, Rorsman NJG, Spiliotis II, Tarasov A, Wu Y, Ashcroft FM, Rorsman P. Insulin inhibits glucagon release by SGLT2-induced stimulation of somatostatin secretion. Nat Commun. 2019 Jan 11;10(1):139. PMID: 30635569 PMCID: PMC6329806
Vestergaard ET, Hjelholt AJ, Kuhre RE, Møller N, Larraufie P, Gribble FM, Reimann F, Jessen N, Holst JJ, Jørgensen JOL. Acipimox Acutely Increases GLP-1 Concentrations in Overweight Subjects and Hypopituitary Patients. J Clin Endocrinol Metab. 2019 Jul 1;104(7):2581- 2592. PMID:30726969; PMCID:PMC7212086
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Watson LPE, Carr KS, Venables MC, Acerini CL, Lyons G, Moran C, Murgatroyd PR, Chatterjee K. Quantifying energy expenditure in childhood: utility in managing pediatric metabolic disorders. Am J Clin Nutr. 2019 Nov 1;110(5):1186-1191. PMID: 31410443. PMCID: PMC6821543.
Wejaphikul K, Groeneweg S, Hilhorst-Hofstee Y, Chatterjee VK, Peeters RP, Meima ME, Visser WE. Insight into molecular determinants of T3 vs. T4 recognition from mutations in thyroid hormone receptor alpha and beta. J.Clin. Endocrinol. Metab. (2019). PMID:30817817; PMCID:PMC6599431
Westwater ML, Vilar-López R, Ziauddeen H, Verdejo-García A, Fletcher PC. Combined effects of age and BMI are related to altered cortical thickness in adolescence and adulthood. Dev Cogn Neurosci. 2019 Dec;40:100728. Epub 2019 Nov 5. PubMed PMID: 31751856; PubMed Central PMCID: PMC6913515.
Wieczorek A, Perani CV, Nixon M, Constancia M, Sandovici I, Zazara DE, Leone G, Zhang MZ, Arck PC, Solano ME. Sex-specific regulation of stress-induced fetal glucocorticoid surge by the mouse placenta. Am J Physiol Endocrinol Metab. 2019 Jul 1;317(1):E109-E120. Epub 2019 Apr 16. PMID:30990748
Wray JR, Davies A, Sefton C, Allen TJ, Adamson A, Chapman P, Lam BYH, Yeo GSH, Coll AP, Harno E, White A. Global transcriptomic analysis of the arcuate nucleus following chronic glucocorticoid treatment. Mol Metab. 2019 Aug;26:5-17. PubMed PMID: 31176677.
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Yeo SH, Kyle V, Blouet C, Jones S, Colledge WH. Mapping neuronal inputs to Kiss1 neurons in the arcuate nucleus of the mouse. PLoS One. 2019 Mar 27;14(3):e0213927. eCollection 2019. PMID:30917148; PMCID:PMC6436706
Ziegler AN, Feng Q, Chidambaram S, Testai JM, Kumari E, Rothbard DE, Constancia M, Sandovici I, Cominski T, Pang K, Gao N, Wood TL, Levison SW. Insulin-like Growth Factor II: An Essential Adult Stem Cell Niche Constituent in Brain and Intestine. Stem Cell Reports. 2019 Apr 9;12(4):816-830. doi: 10.1016/j.stemcr.2019.02.011. PMID: 30905741 PMCID: PMC6450461

2018

Adriaenssens AE, Reimann F, Gribble FM.Distribution and Stimulus Secretion Coupling of En- teroendocrine Cells along the Intestinal Tract. Compr Physiol. 2018 Sep 14;8(4):1603-1638.
Aprile M, Cataldi S, Ambrosio MR, D’Esposito V, Lim K, Dietrich A, Blüher M, Savage DB, Formisano P, Ciccodicola A, Costa V. PPARγΔ5, a Naturally Occurring Dominant-Negative Splice Isoform, Impairs PPARγ Function and Adipocyte Differentiation. Cell Rep. 2018 Nov 6;25 (6):1577-1592.e6. doi: 10.1016/j.celrep.2018.10.035.PMID:30404011
Bally L, Thabit H, Hovorka R. Closed-Loop Insulin for Glycemic Control in Noncritical Care. N Engl J Med. 2018 Nov 15;379(20):1970-1971. doi: 10.1056/NEJMc1811995. No abstract availa- ble. PMID:30428293
Bauzá-Thorbrügge M, Rodríguez-Cuenca S, Vidal-Puig A, Galmés-Pascual BM, Sbert-Roig M, Gianotti M, Lladó I, Proenza AM J. GPER and ERα mediate estradiol enhancement of mitochon- drial function in inflamed adipocytes through a PKA dependent mechanism. Steroid Biochem Mol Biol. 2018 Sep 22. pii: S0960-0760(18)30068-2. PMID:30253224
Beeson JH, Blackmore HL, Carr SK, Dearden L, Duque-Guimarães DE, Kusinski LC, Pantaleão LC, Pinnock AG, Aiken CE, Giussani DA, Fernandez-Twinn DS, Ozanne SE. Maternal exercise intervention in obese pregnancy improves the cardiovascular health of the adult male offspring. Mol Metab. 2018 Oct;16:35-44. PMID: 30293577.PMCID: PMC6157615
Berends LM, Dearden L, Tung YCL, Voshol P, Fernandez-Twinn DS, Ozanne SE. Programming of central and peripheral insulin resistance by low birthweight and postnatal catch-up growth in male mice. Diabetologia. 2018 Oct;61(10):2225-2234. PMID: 30043179PMCID: PMC6133152
Billing LJ, Smith CA, Larraufie P, Goldspink DA, Galvin S, Kay RG, Howe JD, Walker R, Pruna M, Glass L, Pais R, Gribble FM, Reimann F.Co-storage and release of insulin-like peptide-5, glu- cagon-like peptide-1 and peptideYY from murine and human colonic enteroendocrine cells. Mol Metab. 2018 Oct;16:65-75. PMID: 30104166 PMCID: PMC6158034
Boughton CK, Hovorka R. Is an artificial pancreas (closed-loop system) for Type 1 diabetes ef- fective? Diabet Med. 2018 Sep 5. Review. PMID: 30183096
Chase JG, Desaive T, Bohe J, Cnop M, De Block C, Gunst J, Hovorka R, Kalfon P, Krinsley J, Renard E, Preiser JC. Improving glycemic control in critically ill patients: personalized care to mimic the endocrine pancreas. Crit Care. 2018 Aug 2;22(1):182. Review. PMID: 30071851 PMCID: PMC6091026
Church D, Cardoso L, Kay RG, Williams CL, Freudenthal B, Clarke C, Harris J, Moorthy M, Kar- ra E, Gribble FM, Reimann F, Burling K, Williams AJK, Munir A, Jones TH, Führer D, Moeller LC, Cohen M, Khoo B, Halsall D, Semple RK. Assessment and Management of Anti-Insulin Auto- antibodies in Varying Presentations of Insulin Autoimmune Syndrome. J Clin Endocrinol Metab. 2018 Oct 1;103(10):3845-3855. PMID: 30085133 PMCID: PMC6179165
Farrington C, Stewart Z, Hovorka R, Murphy HJ. Women’s Experiences of Day-and-Night Closed-Loop Insulin Delivery During Type 1 Diabetes Pregnancy. Diabetes Sci Technol. 2018 Oct 5:1932296818800065. PMID: 30288999PMCID: PMC6232744
Goldspink DA, Reimann F, Gribble FM. Models and Tools for Studying Enteroendocrine Cells. Endocrinology. 2018 Sep 14. doi: 10.1210/en.2018-00672. PMID:30239642
Harno E, Gali Ramamoorthy T, Coll AP, White A.POMC: The Physiological Power of Hormone Processing. Physiol Rev. 2018 Oct 1;98(4):2381-2430. PMID: 30156493PMCID: PMC6170974
Hendricks AE, Billups SC, Pike HNC, Farooqi IS, Zeggini E, Santorico SA, Barroso I, Dupuis J. ProxECAT: Proxy External Controls Association Test. A new case-control gene region associ- ation test using allele frequencies from public controls. PLoS Genet. 2018 Oct 16;14 (10):e1007591. PMID: 30325923PMCID: PMC6191077
Holt MK, Richards JE, Cook DR, Brierley DI, Williams DL, Reimann F, Gribble FM, Trapp S. Preproglucagon Neurons in the Nucleus of the Solitary Tract are the Main Source of Brain GLP-1, Mediate Stress-Induced Hypophagia, and Limit Unusually Large Intakes of Food. Diabe- tes. 2018 Oct 2. pii: db180729. PMID: 30279161PMCID: PMC6314470
Jenkins B, Aoun M, Feillet-Coudray C, Coudray C, Ronis M, Koulman A. The Dietary Total-Fat Content Affects the In Vivo Circulating C15:0 and C17:0 Fatty Acid Levels Independently. Nutri- ents. 2018 Nov 3;10(11). pii: E1646. doi: 10.3390/nu10111646.PMID:30400275
Kirwan P, Kay RG, Brouwers B, Herranz-Pérez V, Jura M, Larraufie P, Jerber J, Pembroke J, Bartels T, White A, Gribble FM, Reimann F, Farooqi IS, O’Rahilly S, Merkle FT. Quantitative mass spectrometry for human melanocortin peptides in vitro and in vivo suggests prominent roles for β-MSH and desacetyl α-MSH in energy homeostasis. Mol Metab. 2018 Nov;17:82-97. PMID: 30201275 PMCID: PMC6197775
Klonoff DC, Evans ML, Lane W, Kempe HP, Renard E, Hans DeVries J, Graungaard T, Hyseni A, Gondolf T, Battelino T. A randomized, multicentre trial evaluating the efficacy and safety of fast-acting insulin aspart in continuous subcutaneous insulin infusion in adults with type 1 diabe- tes (onset 5). Diabetes Obes Metab. 2018 Dec 9. doi: 10.1111/dom.13610. PMID:30537180
Lawton J, Blackburn M, Rankin D, Allen J, Campbell F, Leelarathna L, Tauschmann M, Thabit H, Wilinska ME, Hovorka R; APCam11 Consortium. The impact of using a closed-loop system on food choices and eating practices among people with Type 1 diabetes: a qualitative study involving adults, teenagers and parents. Diabet Med. 2018 Dec 21. doi: 10.1111/dme.13887. PMID: 30575114PMCID: PMC6510609
Lotta LA, Stewart ID, Sharp SJ, Day FR, Burgess S, Luan J, Bowker N, Cai L, Li C, Wittemans LBL, Kerrison ND, Khaw KT, McCarthy MI, O’Rahilly S, Scott RA, Savage DB, Perry JRB, Langenberg C, Wareham NJ. Association of Genetically Enhanced Lipoprotein Lipase-Mediated Lipolysis and Low-Density Lipoprotein Cholesterol-Lowering Alleles With Risk of Coronary Dis- ease and Type 2 Diabetes. JAMA Cardiol. 2018 Oct 1;3(10):957-966. PMID: 30326043PMCID: PMC6217943
Mann JP, Vreugdenhil A, Socha P, Jańczyk W, Baumann U, Rajwal S, Casswall T, Marcus C, van Mourik I, O’Rahilly S, Savage DB, Noble-Jamieson G, Lacaille F, Dabbas M, Dubern B, Kelly DA, Nobili V, Anstee European paediatric non-alcoholic fatty liver disease registry (EU- PNAFLD): Design and rationale. Contemp Clin Trials. 2018 Dec;75:67-71. doi: 10.1016/ j.cct.2018.11.003. Epub 2018 Nov 5. PMID30408605
Martin-Gallausiaux C, Larraufie P, Jarry A, Béguet-Crespel F, Marinelli L, Ledue F, Reimann F, Blottière HM, Lapaque N.Butyrate Produced by Commensal Bacteria Down-Regulates Indola- mine 2,3-Dioxygenase 1 (IDO-1) Expression via a Dual Mechanism in Human Intestinal Epitheli- al Cells. Front Immunol. 2018 Dec 11;9:2838. doi: 10.3389/fimmu.2018.02838. eCollection 2018.PMID:30619249 PMCID: PMC6297836
Menting MD, van de Beek C, Mintjens S, Wever KE, Korosi A, Ozanne SE, Limpens J, Rose- boom TJ, Hooijmans C, Painter RC. The link between maternal obesity and offspring neurobe- havior: a systematic review of animal experiments. Neurosci Biobehav Rev. 2019 Jan 3. pii: S0149-7634(18)30523-2. doi: 10.1016/j.neubiorev.2018.12.023. Review.PMID:30611800
Munthali RJ, Manyema M, Said-Mohamed R, Kagura J, Tollman S, Kahn K, Gómez-Olivé FX, Micklesfield LK, Dunger D, Norris SA. Body composition and physical activity as mediators in the relationship between socioeconomic status and blood pressure in young South African women: a structural equation model analysis. BMJ Open 2018 Dec 19;8(12):e023404. doi: 10.1136/bmjopen-2018-023404 PMID: 30573484PMCID: PMC6303607
Niu Y, Kane AD, Lusby CM, Allison BJ, Chua YY, Kaandorp JJ, Nevin-Dolan R, Ashmore TJ, Blackmore HL, Derks JB, Ozanne SE, Giussani DA.Maternal Allopurinol Prevents Cardiac Dys- function in Adult Male Offspring Programmed by Chronic Hypoxia During Pregnancy. Hyperten- sion. 2018 Oct;72(4):971-978. PMID: 30354714PMCID: PMC6135482
Pellegrinelli V, Peirce VJ, Howard L, Virtue S, Türei D, Senzacqua M, Frontini A, Dalley JW, Hor- ton AR, Bidault G, Severi I, Whittle A, Rahmouni K, Saez-Rodriguez J, Cinti S, Davies AM, Vidal- Puig A. Adipocyte-secreted BMP8b mediates adrenergic-induced remodeling of the neuro- vascular network in adipose tissue. Nat Commun. 2018 Nov 26;9(1):4974. doi: 10.1038/s41467- 018-07453-x.PMID:30478315
Petrus P, Mejhert N, Corrales P, Lecoutre S, Li Q, Maldonado E, Kulyté A, Lopez Y, Campbell M, Acosta JR, Laurencikiene J, Douagi I, Gao H, Martínez-Álvarez C, Hedén P, Spalding KL, Vidal-Puig A, Medina-Gomez G, Arner P. Transforming Growth Factor-β3 Regulates Adipocyte Number in Subcutaneous White Adipose Tissue. Rydén M.Cell Rep. 2018 Oct 16;25(3):551- 560.e5. PMID: 30332637
Petry CJ, Ong KK, Burling KA, Barker P, Goodburn SF, Perry JRB, Acerini CL, Hughes IA, Painter RC, Afink GB, Dunger DB, O’Rahilly S. Associations of vomiting and antiemetic use in pregnancy with levels of circulating GDF15 early in the second trimester: A nested case-control study. Wellcome Open Res. 2018 Sep 21;3:123. PMID: 30345390 PMCID: PMC6171563
Rached MT, Millership SJ, Pedroni SMA, Choudhury AI, Costa ASH, Hardy DG, Glegola JA, Ir- vine EE, Selman C, Woodberry MC, Yadav VK, Khadayate S, Vidal-Puig A, Virtue S, Frezza C, Withers DJ. Deletion of myeloid IRS2 enhances adipose tissue sympathetic nerve function and limits obesity. Mol Metab. 2018 Nov 28. pii: S2212-8778(18)31025-1. doi: 10.1016/ j.molmet.2018.11.010. PMID:30553769
Recino A, Gan SU, Sia KC, Sawyer Y, Trendell J, Kay R, Gribble FM, Reimann F, Foale R, No- taridou M, Holmes N, Lever A, Lee KO, Nathwani A, Cooke A, Calne R, Wallberg M. Immunosuppression overcomes insulin- and vector-specific immune responses that limit effi- cacy of AAV2/8-mediated insulin gene therapy in NOD mice. Gene Ther. 2018 Dec 4. doi: 10.1038/s41434-018-0052-5. PMID:30514969
Roche EF, McGowan A, Koulouri O, Turgeon MO, Nicholas AK, Heffernan E, El-Khairi R, Abid N, Lyons G, Halsall D, Bonomi M, Persani L, Dattani MT, Gurnell M, Bernard DJ, Schoenmakers N. A novel IGSF1 mutation in a large Irish kindred highlights the need for familial screening in the IGSF1 deficiency syndrome. Clin Endocrinol (Oxf). 2018 Dec;89(6):813-823. doi: 10.1111/ cen.13827. PMID:30086211
Rudenko O, Shang J, Munk A, Ekberg JP, Petersen N, Engelstoft MS, Egerod KL, Hjorth SA, Wu M, Feng Y, Zhou YP, Mokrosinski J, Thams P, Reimann F, Gribble F, Rehfeld JF, Holst JJ, Tree- bak JT, Howard AD, Schwartz TW. The aromatic amino acid sensor GPR142 controls metabolism through balanced regulation of pancreatic and gut hormones. Mol Metab. 2019 Jan;19:49-64. doi: 10.1016/j.molmet.2018.10.012. Epub 2018 Nov 5. PMID:30472415
Senyilmaz-Tiebe D, Pfaff DH, Virtue S, Schwarz KV, Fleming T, Altamura S, Muckenthaler MU, Okun JG, Vidal-Puig A, Nawroth P, Teleman AA. Dietary stearic acid regulates mitochondria in vivo in humans. Nat Commun. 2018 Aug 7;9(1):3129. PMID: 30087348PMCID: PMC6081440
Smith MA, Katsouri L, Virtue S, Choudhury AI, Vidal-Puig A, Ashford MLJ, Withers DJ Calcium Channel CaV2.3 Subunits Regulate Hepatic Glucose Production by Modulating Leptin-Induced Excitation of Arcuate Pro-opiomelanocortin Neurons. Cell Rep. 2018 Oct 9;25(2):278-287.e4. PMID: 30304668 PMCID: PMC6198286
Speakman JR, Loos RJF, O’Rahilly S, Hirschhorn JN, Allison DB. GWAS for BMI: a treasure trove of fundamental insights into the genetic basis of obesity. Int J Obes (Lond). 2018 Aug;42 (8):1524-1531. PMID: 29980761PMCID: PMC6115287
Tauschmann M, Thabit H, Bally L, Allen JM, Hartnell S, Wilinska ME, Ruan Y, Sibayan J, Koll- man C, Cheng P, Beck RW, Acerini CL, Evans ML, Dunger DB, Elleri D, Campbell F, Bergenstal RM, Criego A, Shah VN, Leelarathna L, Hovorka R; Closed-loop insulin delivery in suboptimally controlled type 1 diabetes: a multicentre, 12-week randomised trial. Lancet. 2018 Oct 13;392(10155):1321-1329. Erratum in: Lancet. 2018 Oct 13;392 (10155):1310 PMID: 30292578 PMCID: PMC6182127
Turco MY, Gardner L, Kay RG, Hamilton RS, Prater M, Hollinshead MS, McWhinnie A, Esposito L, Fernando R, Skelton H, Reimann F, Gribble FM, Sharkey A, Marsh SGE, O’Rahilly S, Hem- berger M, Burton GJ, Moffett A. Trophoblast organoids as a model for maternal-fetal interactions during human placentation. Nature. 2018 Dec;564(7735):263-267. doi: 10.1038/s41586-018- 0753-3. Epub 2018 Nov 28.PMID:30487605
Vidal-Puig A, Enerback S.J “Obesity-associated metabolic complications, the second wave of the tsunami” 14th Key Symposium. Intern Med. 2018 Nov;284(5):447-449. PMID: 30141829
Virtue S, Petkevicius K, Moreno-Navarrete JM, Jenkins B, Hart D, Dale M, Koulman A, Fernán- dez-Real JM, Vidal-Puig A. Peroxisome Proliferator-Activated Receptor γ2 Controls the Rate of Adipose Tissue Lipid Storage and Determines Metabolic Flexibility. Cell Rep. 2018 Aug 21;24 (8):2005-2012.e7. PMID: 30134163 PMCID: PMC6113930
Whyte MB, Shojaee-Moradie F, Sharaf SE, Jackson NC, Fielding B, Hovorka R, Mendis J, Rus- sell-Jones D, Umpleby AM.J Lixisenatide reduces chylomicron triacylglycerol due to increased clearance. Clin Endocrinol Metab. 2018 Sep 11. PMID: 30215735PMCID: PMC6300412
Zangemeister L, Grabenhorst F, Schultz W. Neural Basis for Economic Saving Strategies in Hu- man Amygdala-Prefrontal Reward Circuits. Curr Biol. 2016 Nov 21;26(22):3004-3013. doi: 10.1016/j.cub.2016.09.016. Epub 2016 Oct 20.PMID:27773572

2017

Ahmed RM, Landin-Romero R, Collet TH, van der Klaauw AA, Devenney E, Henning E, Kiernan MC, Piguet O, Farooqi IS, Hodges JR. Energy expenditure in frontotemporal dementia: a behavioural and imaging study. Brain 2017;140:171-83.
Anderberg RH, [11 authors; Gribble FM: 8, Reimann F: 9], Skibicka KP. Glucagon-like peptide-1 and its analogues act in the dorsal raphe and modulate central serotonin to reduce appetite and body weight. Diabetes 2017; 66:1062-1073.
Annamalai AK, Jeyachitra G, Jeyamithra A, Ganeshkumar M, Srinivasan KG, Gurnell M. Gestational Pituitary Apoplexy. Indian J Endocrinol Metab. 2017; 21:484-485.
Arif S, Gibson VB, Nguyen V, Bingley PJ, Todd JA, Guy C, Dunger DB, Dayan CM, Powrie J, Lorenc A, Peakman M. β-cell specific T-lymphocyte response has a distinct inflammatory phenotype in children with Type 1 diabetes compared with adults. Diabet Med. 2017; 34:419-25.
Aycan Z, Cangul H, Muzza M, Bas VN, Fugazzola L, Chatterjee VK, Persani L, Schoenmakers N. Digenic DUOX1 and DUOX2 mutations in cases with congenital hypothyroidism. J Clin Endocrinol Metab. 2017. [Epub ahead of print]
Bally L, Thabit H, Kojzar H, Mader JK, Qerimi-Hyseni J, Hartnell S, Tauschmann M, Allen JM, Wilinska ME, Pieber TR, Evans ML, Hovorka R Day-and-night glycaemic control with closed-loop insulin delivery versus conventional insulin pump therapy in free-living adults with well controlled type 1 diabetes: an open-label, randomised, crossover study. Lancet Diabetes Endocrinol. 2017; 5: 261-270.
Barnard KD, Wysocki T, Ully V, Mader JK, Pieber TR, Thabit H, Tauschmann M, Leelarathna L, Hartnell S, Acerini CL, Wilinska ME, Dellweg S, Benesch C, Arnolds S, Holzer M, Kojzar H, Campbell F, Yong J, Pichierri J, Hindmarsh P, Heinemann L, Evans ML, Hovorka R Closing the Loop in Adults, Children and Adolescents With Suboptimally Controlled Type 1 Diabetes Under Free Living Conditions: A Psychosocial Substudy. J Diabetes Sci Technol. 2017. [Epub ahead of print]
Boudellioua I, Mahamad Razali RB, Kulmanov M, Hashish Y, Bajic VB, Goncalves-Serra E, Schoenmakers N, Gkoutos GV, Schofield PN, Hoehndorf R. Semantic prioritization of novel causative genomic variants. PLoS Comput Biol. 2017; 13:e1005500.
Bulger DA, Fukushige T, Yun S, Semple RK, Hanover JA, Krause MW. Caenorhabditis elegans DAF-2 as a model for human insulin receptoropathies. G3 (Bethesda). 2017; 7:257-68.
Burke LK, Darwish T, Cavanaugh AR, Virtue S, Roth E, Morro J, Liu SM, Xia J, Dalley JW, Burling K, Chua A, Vidal-Puig A, Schwartz GJ, Blouet C. mTORC1 in AGRP neurons integrates exteroceptive and interoceptive food-related cues in the modulation of adaptive energy expenditure in mice. eLife. 2017; 6: e22848.
Church D, Cardoso L, Bradbury S, Clarke C, Stears A, Dover A, Halsall D, Semple R. Diagnosis of insulin autoimmune syndrome using polyethylene glycol precipitation and gel filtration chromatography with ex vivo insulin exchange. Clin Endocrinol (Oxf). 2017;86:347-353.
De Almeida Faria J, Duque-Guimaraes D, Carpenter AAM, Loche E, Ozanne SE. A post-weaning obesogenic diet exacerbates the detrimental effects of maternal obesity on offspring insulin signaling in adipose tissue. Sci Rep. 2017; 24: 44949.
Diederen KM, Ziauddeen H, Vestergaard MD, Spencer T, Schultz W, Fletcher PC. Dopamine Modulates Adaptive Prediction Error Coding in the Human Midbrain and Striatum. J Neurosci. 2017; 37:1708-1720.
Duque-Guimarães DE, de Almeida-Faria J, Ong TP, Ozanne SE. Pulsed SILAC as a approach for miRNA targets identification in cell culture. Methods Mol Biol. 2017;1546:149-59.
Emami A, Willinska ME, Thabit H, Leelarathna L, Hartnell S, Dellweg S, Benesch C, Mader JK, Holzer M, Kojzar H, Pieber TR, Arnolds S, Evans ML, Hovorka R. Behavioral Patterns and Associations with Glucose Control During 12-Week Randomized Free-Living Clinical Trial of Day and Night Hybrid Closed-Loop Insulin Delivery in Adults with Type 1 Diabetes. Diabetes Technol Ther. 2017; 19:433-437.
Farrington C, Stewart ZA, Barnard K, Hovorka R, Murphy HR. Experiences of closed-loop insulin delivery among pregnant women with Type 1 diabetes. Diabet Med. 2017. [Epub ahead of print]
Fernandez-Twinn DS, Gascoin G, Musial B, Carr S, Duque-Guimaraes D, Blackmore HL, Alfaradhi MZ, Loche E, Sferruzzi-Perri A, Fowden AL, Ozanne SE. Exercise rescues obese mothers’ insulin sensitivity, placental hypoxia and offspring insulin sensitivity. Sci Rep. 2017;7:44650.
García-García F, Hovorka R, Wilinska ME, Elleri D, Hernando ME. Modelling the effect of insulin on the disposal of meal-attributable glucose in type 1 diabetes. Med Biol Eng Comput. 2017; 55:271-282.
Graff M, Scott RA, [259 authors], CHARGE Consortium.; EPIC-InterAct Consortium.; PAGE Consortium., [1 author], Barroso I: 262, [18 authors], Kilpeläinen TO. Genome-wide physical activity interactions in adiposity – A meta-analysis of 200,452 adults. PLoS Genet. 2017; 13:e1006528.
Hameed S, Patterson M, Dhillo WS, Rahman SA, Ma Y, Holton C, Gogakos A, Yeo GSH, Lam BYH, Polex-Wolf J, Fenske W, Bell J, Anastasovska J, Samarut J, Bloom SR, Bassett JHD, Williams GR, Gardiner JV Thyroid Hormone Receptor Beta in the Ventromedial Hypothalamus Is Essential for the Physiological Regulation of Food Intake and Body Weight. Cell Rep. 2017;19:2202-2209.
Hendricks AE, [30 authors] O’Rahilly S: 32, Zeggini E, Barroso I: 34, Farooqi IS. Understanding Society Scientific Group; EPIC-CVD Consortium; UK10K Consortium. Rare Variant Analysis of Human and Rodent Obesity Genes in Individuals with Severe Childhood Obesity. Sci Rep. 2017; 7:4394.
Improda N, Ponmani C, Schoenmakers N, Senniappan S, Atterbury A, Barnicoat A, Chatterjee K, Dattani MT. Intrafamilial Phenotypic Variability and Consequences of Non-Compliance with Treatment in Congenital Adrenal Hyperplasia and Congenital Hypothyroidism within a Single Family. Horm Res Paediatr. 2017. [Epub ahead of print]
Justice AE, [297 authors], Barroso I 299, [16 authors], Cupples LA. Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits. Nat Commun. 2017; 8:14977.
Koseki H, Donegá M, Lam BY, Petrova V, van Erp S, Yeo GS, Kwok JC, Ffrench-Constant C, Eva R, Fawcett J. Selective Rab11 transport and the intrinsic regenerative ability of CNS axons. eLife. 2017. [Epub ahead of print]
Lam BYH, Cimino I, Polex-Wolf J, Nicole Kohnke S, Rimmington D, Iyemere V, Heeley N, Cossetti C, Schulte R, Saraiva LR, Logan DW, Blouet C, O’Rahilly S, Coll AP, Yeo GSH Heterogeneity of hypothalamic pro-opiomelanocortin-expressing neurons revealed by single-cell RNA sequencing. Mol Metab. 2017; 6:383-392.
Leiter SM, Parker VER, Welters A, Knox R, Rocha N, Clark G, Payne F, Lotta L, Harris J, Guerrero-Fernández J, González-Casado I, García-Miñaur S, Gordo G, Wareham N, Martínez-Glez V, Allison M, O’Rahilly S, Barroso I, Meissner T, Davies S, Hussain K, Temple K, Barreda-Bonis AC, Kummer S, Semple RK. Hypoinsulinaemic, hypoketotic hypoglycaemia due to mosaic genetic activation of PI3-kinase. Eur J Endocrinol. 2017; 177:175-186.
Li M, Li Y, [60 authors], CHARGE Glycemic-T2D Working Group, CHARGE Blood Pressure Working Group, [94 authors], Chu AY. SOS2 and ACP1 Loci Identified through Large-Scale Exome Chip Analysis Regulate Kidney Development and Function. J Am Soc Nephrol. 2017; 28:981-994.
Lin X, Lim IY, Wu Y, Teh AL, Chen L, Aris IM, Soh SE, Tint MT, MacIsaac JL, Morin AM, Yap F, Tan KH, Saw SM, Kobor MS, Meaney MJ, Godfrey KM, Chong YS, Holbrook JD, Lee YS, Gluckman PD, Karnani N; GUSTO study group. Developmental pathways to adiposity begin before birth and are influenced by genotype, prenatal environment and epigenome. BMC Med. 2017; 15:50.
Lotta LA, [29 authors], O’Rahilly S, Scott RA. Integrative genomic analysis implicates limited peripheral adipose storage capacity in the pathogenesis of human insulin resistance. Nat Genet. 2017; 49:17-26. Corrigendum 2017; 49:317.
Ma D, Ozanne SE, Guest PC A Protocol for Producing the Maternal Low-Protein Rat Model: A Tool for Preclinical Proteomic Studies. Adv Exp Med Biol. 2017; 974:251-255.
Maniero C, Garg S, Zhao W, Johnson TI, Zhou J, Gurnell M, Brown MJ. NEFM (Neurofilament Medium) Polypeptide, a Marker for Zona Glomerulosa Cells in Human Adrenal, Inhibits D1R (Dopamine D1 Receptor)-Mediated Secretion of Aldosterone. Hypertension. 2017; 70:357-364.
Manning A, [192 authors], O’Rahilly SP: 194, [6 authors], Barroso I: 201, [60 authors], Lindgren CM. A Low-Frequency Inactivating AKT2 Variant Enriched in the Finnish Population Is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk. Diabetes. 2017; 66:2019-2032.
Martínez-Sánchez N, [21 authors], Chatterjee K: 22, [5 authors], Coll AP: 28, Vidal-Puig A: 29, [10 authors], López M. Hypothalamic AMPK-ER Stress-JNK1 Axis Mediates the Central Actions of Thyroid Hormones on Energy Balance. Cell Metab. 2017; 26:212-229.
Mele L, Carobbio S, Brindani N, Curti C, Rodriguez-Cuenca S, Bidault G, Mena P, Zanotti I, Vacca M, Vidal-Puig A, Del Rio D Phenyl-γ-valerolactones, flavan-3-ol colonic metabolites, protect brown adipocytes from oxidative stress without affecting their differentiation or function. Mol Nutr Food Res. 2017. [Epub ahead of print]
Minic M, Rocha N, Harris J, Groeneveld MP, Leiter S, Wareham N, Sleigh A, De Lonlay P, Hussain K, O’Rahilly S, Semple RK Constitutive activation of AKT2 in humans leads to hypoglycemia without fatty liver or metabolic dyslipidemia. J Clin Endocrinol Metab. 2017; 102:2914-2921.
Musial B, Vaughan O, Fernandez-Twinn DS, Voshol P, Ozanne SE, Fowden A, Sferruzzi-Perri A. A Western-style obesogenic diet alters maternal metabolic physiology with consequences for fetal nutrient acquisition in mice. J Physiol. 2017. [Epub ahead of print]
Nøhr AC, Shehata MA, Hauser AS, Isberg V, Mokrosinski J, Andersen KB, Farooqi IS, Pedersen DS, Gloriam DE, Bräuner-Osborne H. The orphan G protein-coupled receptor GPR139 is activated by the peptides: Adrenocorticotropic hormone (ACTH), α-, and β-melanocyte stimulating hormone (α-MSH, and β-MSH), and the conserved core motif HFRW. Neurochem Int. 2017;102:105-13.
Nus M, Sage AP, Lu Y, Masters L, Lam BYH, Newland S, Weller S, Tsiantoulas D, Raffort J, Marcus D, Finigan A, Kitt L, Figg N, Schirmbeck R, Kneilling M, Yeo GSH, Binder CJ, de la Pompa JL, Mallat Z. Marginal zone B cells control the response of follicular helper T cells to a high-cholesterol diet. Nat Med. 2017; 23:601-610.
Olcese C, [40 authors], UK10K Rare Group, [4 authors], Mitchison HM. X-linked primary ciliary dyskinesia due to mutations in the cytoplasmic axonemal dynein assembly factor PIH1D3. Nat Commun. 2017; 8:14279.
O’Reilly MW, Kempegowda P, Walsh M, Taylor AE, Manolopoulos KN, Allwood JW, Semple RK, Hebenstreit D, Dunn WB, Tomlinson JW, Arlt W.J AKR1C3-mediated adipose androgen generation drives lipotoxicity in women with polycystic ovary syndrome. Clin Endocrinol Metab. 2017; [Epub ahead of print].
Ouyang J, Hardy R, Brown M, Helliwell T, Gurnell M, Cuthbertson DJ. 11C-metomidate PET-CT scanning can identify aldosterone-producing adenomas after unsuccessful lateralisation with CT/MRI and adrenal venous sampling. J Hum Hypertens. 2017; 31:483-484.
Pestana D, Teixeira D, Meireles M, Marques C, Norberto S, Sá C, Fernandes VC, Correia-Sá L, Faria A, Guardão L, Guimarães JT, Cooper WN, Sandovici I, Domingues VF, Delerue-Matos C, Monteiro R, Constância M, Calhau C.Adipose tissue dysfunction as a central mechanism leading to dysmetabolic obesity triggered by chronic exposure to p,p’-DDE. Sci Rep. 2017; 7:2738.
Petry CJ, Mooslehner K, Prentice P, Hayes MG, Nodzenski M, Scholtens DM, Hughes IA, Acerini CL, Ong KK, Lowe WL Jr, Dunger DB. Associations between a fetal imprinted gene allele score and late pregnancy maternal glucose concentrations. Diabetes Metab. 2017. [Epub ahead of print]
Pompa A, De Marchis F, Pallotta MT, Benitez-Alfonso Y, Jones A, Schipper K, Moreau K, Žárský V, Di Sansebastiano GP, Bellucci M. Unconventional Transport Routes of Soluble and Membrane Proteins and Their Role in Developmental Biology. Int J Mol Sci. 2017; 18(4).
Psichas A, Tolhurst G, Brighton CA, Gribble FM, Reimann F. Mixed Primary Cultures of Murine Small Intestine Intended for the Study of Gut Hormone Secretion and Live Cell Imaging of Enteroendocrine Cells. J Vis Exp. 2017; 122:55687.
Rocha NM, [14 authors], Barroso I: 16, [10 authors], O’Rahilly SI: 27, [2 authors], Savage DB: 30, Semple RK Human biallelic MFN2 mutations induce mitochondrial dysfunction, upper body adipose hyperplasia, and suppression of leptin expression. eLife. 2017; 6: e23813.
Ruan Y, Thabit H, Leelarathna L, Hartnell S, Willinska ME, Tauschmann M, Dellweg S, Benesch C, Mader JK, Holzer M, Kojzar H, Evans ML, Pieber TR, Arnolds S, Hovorka R; AP@home consortium. Faster insulin action is associated with improved glycemic outcomes during closed-loop insulin delivery and sensor-augmented pump therapy in adults with type 1 diabetes. Diabetes Obes Metab. 2017. [Epub ahead of print]
Sferruzzi-Perri AN, Sandovici I, Constancia M, Fowden AL. Placental phenotype and the insulin-like growth factors: resource allocation to fetal growth. J Physiol. 2017; 595:5057-5093.
Taku N, Gurnell M, Burnet N, Jena R. Time dependence of radiation-induced hypothalamic-pituitary axis dysfunction in adults treated for non-pituitary, intracranial neoplasms. Clin Oncol (R Coll Radiol). 2017;29:34-41.
Teo AE, Garg S, Johnson TI, Zhao W, Zhou J, Gomez-Sanchez CE, Gurnell M, Brown MJ. Physiological and Pathological Roles in Human Adrenal of the Glomeruli-Defining Matrix Protein NPNT (Nephronectin). Hypertension. 2017; 69:1207-1216. Apr 17.
Thabit H, Hartnell S, Allen JM, Lake A, Wilinska ME, Ruan Y, Evans ML, Coll AP, Hovorka R. Closed-loop insulin delivery in inpatients with type 2 diabetes: a randomised, parallel-group trial. R.Lancet Diabetes Endocrinol. 2017; 5:117-124.
Tripolszki K, Farkas K, Sulák A, Szolnoky G, Duga B, Melegh B, Knox RG, Parker VER, Semple RK, Kemény L, Széll M, Nagy N. Atypical neurofibromatosis type 1 with unilateral limb hypertrophy mimicking overgrowth syndrome. Clin Exp Dermatol. 2017. [Epub ahead of print]
Tsoukalas M, Psichas A, Reimann F, Gribble FM, Lobstein A, Urbain A. Pregnane glycosides from Cynanchum menarandrense. Steroids. 2017; 125:27-32.
Tsuchiya Y, Peak-Chew S, Newell C, Miller-Aidoo S, Mangal S, Zhyvoloup A, Baković J, Malanchuk O, Pereira G, Kotiadis V, Szabadkai G, Duchen M, Campbell M, Rodriguez Cuenca S, Vidal-Puig A, James A, Murphy MP, Filonenko V, Skehel M, Gout I. Protein CoAlation: A Redox-Regulated Protein Modification by Coenzyme A in Mammalian Cells. Biochem J. 2017; 474:2489-2508.
van der Klaauw AA, Ziauddeen H, Keogh JM, Henning E, Dachi S, Fletcher PC, Farooqi IS Oxytocin administration suppresses hypothalamic activation in response to visual food cues. Sci Rep. 2017; 7:4266.eo CR, Agrawal M, Hoon S, Shabbir A, Shrivastava MK, Huang S, Khoo CM, Chhay V, Yassin MS, Tai ES, Vidal-Puig A, Toh SA. SGBS cells as a model of human adipocyte browning: A comprehensive comparative study with primary human white subcutaneous adipocytes. Sci Rep. 2017; 7:4031.
van Gucht ALM, Moran C, Meima ME, Visser WE, Chatterjee K, Visser TJ, Peeters RP. Resistance to Thyroid Hormone due to Heterozygous Mutations in Thyroid Hormone Receptor Alpha. Curr Top Dev Biol. 2017; 125:337-355.
Vasudevan P, Powell C, Nicholas AK, Scudamore I, Greening J, Park SM, Schoenmakers N. Intrauterine death following intraamniotic triiodothyronine and thyroxine therapy for fetal goitrous hypothyroidism associated with polyhydramnios and caused by a thyroglobulin mutation. Endocrinol Diabetes Metab Case Rep. 2017; 17-0040.
Wheeler SE, Stacey HM, Nahaei Y, Hale SJ, Hardy AB, Reimann F, Gribble FM, Larraufie P, Gaisano HY, Brubaker PL. The SNARE Protein, Syntaxin1a, Plays an Essential Role in Biphasic Exocytosis of the Incretin Hormone, Glucagon-Like Peptide-1. Diabetes. 2017; 66:2327-2338.
Yeo CR, Agrawal M, Hoon S, Shabbir A, Shrivastava MK, Huang S, Khoo CM, Chhay V, Yassin MS, Tai ES, Vidal-Puig A, Toh SA. SGBS cells as a model of human adipocyte browning: A comprehensive comparative study with primary human white subcutaneous adipocytes. Sci Rep. 2017: 7:4031.

2016

(* Open access publications)

Adriaenssens AE, Svendsen B, Lam BY, Yeo GS, Holst JJ, Reimann F, Gribble FM. Transcriptomic profiling of pancreatic alpha, beta and delta cell populations identifies delta cells as a principal target for ghrelin in mouse islets. Diabetologia 2016;59:2156-65. *
Ahmed RM, Irish M, Henning E, Dermody N, Bartley L, Kiernan MC, Piguet O, Farooqi S, Hodges JR. Assessment of eating behavior disturbance and associated neural networks in frontotemporal dementia. JAMA Neurol. 2016;73:282-90.
Aiken CE, Tarry-Adkins JL, Penfold NC, Dearden L, Ozanne SE. Decreased ovarian reserve, dysregulation of mitochondrial biogenesis, and increased lipid peroxidation in female mouse offspring exposed to an obesogenic maternal diet. FASEB J. 2016;30:1548-56. *
Alfaradhi MZ, Kusinski LC, Fernandez-Twinn DS, Pantaleão LC, Carr SK, Ferland-McCollough D, Yeo GS, Bushell M, Ozanne SE. Maternal obesity in pregnancy developmentally programs adipose tissue inflammation in young, lean male mice offspring. Endocrinology 2016;157:4246-56. *
Allison BJ, Kaandorp JJ, Kane AD, Camm EJ, Lusby C, Cross CM, Nevin-Dolan R, Thakor AS, Derks JB, Tarry-Adkins JL, Ozanne SE, Giussani DA. Divergence of mechanistic pathways mediating cardiovascular aging and developmental programming of cardiovascular disease. FASEB J. 2016;30:1968-75. *
Anesten F, Holt MK, Schéle E, Pálsdóttir V, Reimann F, Gribble FM, Safari C, Skibicka KP, Trapp S, Jansson JO. Preproglucagon neurons in the hindbrain have IL-6 receptor-α and show Ca2+ influx in response to IL-6. Am J Physiol Regul Integr Comp Physiol. 2016;311:R115-23. *
Baig S, Parvaresh Rizi E, Shabeer M, Chhay V, Mok SF, Loh TP, Magkos F, Vidal-Puig A, Tai ES, Khoo CM, Toh SA. Metabolic gene expression profile in circulating mononuclear cells reflects obesity-associated metabolic inflexibility. Nutr Metab (Lond). 2016;13:74. *
Boldt K, [54 authors], Group UKRD. An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. Nat Commun. 2016;7:11491. *
Breen DP, Nombela C, Vuono R, Jones PS, Fisher K, Burn DJ, Brooks DJ, Reddy AB, Rowe JB, Barker RA. Hypothalamic volume loss is associated with reduced melatonin output in Parkinson’s disease. Mov Disord. 2016;31:1062-6. *
Burberry A, [15 authors; Merkle FT: 9], Eggan K. Loss-of-function mutations in the C9ORF72 mouse ortholog cause fatal autoimmune disease. Sci Transl Med. 2016;8:347ra93. *
Burke LK, [17 authors], Evans ML, Heisler LK. Sex difference in physical activity, energy expenditure and obesity driven by a subpopulation of hypothalamic POMC neurons. Mol Metab. 2016;5:245-52. *
Carmody D, Ladsaria SS, Buikema RK, Semple RK, Greeley SAW. Successful rhIGF1 treatment for over 5 years in a patient with severe insulin resistance due to homozygous insulin receptor mutation. Diabet Med. 2016;33:e8-12. *
Castillo SD, [26 authors; Semple RK: 23], Vanhaesebroeck B. Somatic activating mutations in Pik3ca cause sporadic venous malformations in mice and humans. Sci Transl Med. 2016;8:332ra43.
Challis BG, Kandasamy N, Powlson AS, Koulouri O, Annamalai AK, Happerfield L, Marker AJ, Arends MJ, Nik-Zainal S, Gurnell M. Familial adrenocortical carcinoma in association with Lynch syndrome. J Clin Endocrinol Metab. 2016;101:2269-72. *
Challis BG, Lim CT, Cluroe A, Cameron E, O’Rahilly S. The McKittrick-Wheelock syndrome: a rare cause of curable diabetes. Endocrinol Diabetes Metab Case Rep. 2016;160013. *
Collet TH, van der Klaauw AA, Henning E, Keogh JM, Suddaby D, Dachi SV, Dunbar S, Kelway S, Dickson SL, Farooqi IS, Schmid SM. The sleep/wake cycle is directly modulated by changes in energy balance. Sleep 2016;39:1691-700. *
Correia-Melo C, [26 authors; Vidal-Puig A: 19], Passos JF. Mitochondria are required for pro-ageing features of the senescent phenotype. EMBO J. 2016;35:724-42.*
Dalgaard K, [28 authors; Yeo GS: 19, O’Rahilly S: 20, Coll AP: 27], Pospisilik JA. Trim28 haploinsufficiency triggers bi-stable epigenetic obesity. Cell 2016;164:353-64. *
Demir T, Onay H, Savage DB, Temeloglu E, Uzum AK, Kadioglu P, Altay C, Ozen S, Demir L, Cavdar U, Akinci B. Familial partial lipodystrophy linked to a novel peroxisome proliferator activator receptor -γ (PPARG) mutation, H449L: a comparison of people with this mutation and those with classic codon 482 Lamin A/C (LMNA) mutations. Diabet Med. 2016;33:1445-50.
Dennedy MC, Annamalai AK, Prankerd Smith O, Freeman N, Vengopal K, Graggaber J, Koulouri O, Powlson AS, Shaw A, Halsall DJ, Gurnell M. Low DHEAS: a sensitive and specific test for detection of subclinical hypercortisolism in adrenal incidentalomas. J Clin Endocrinol Metab. 2016;jc20162718.
Diederen KM, Spencer T, Vestergaard MD, Fletcher PC, Schultz W. Adaptive prediction error coding in the human midbrain and striatum facilitates behavioural adaptation and learning efficiency. Neuron. 2016;90:1127-38. doi: *
Duque-Guimarães DE, de Almeida-Faria J, Ong TP, Ozanne SE. Pulsed SILAC as a approach for miRNA targets identification in cell culture. Methods Mol Biol. 2017;1546:149-59.
Dusaulcy R, Handgraaf S, Heddad-Masson M, Visentin F, Vesin C, Reimann F, Gribble F, Philippe J, Gosmain Y. α-cell dysfunctions and molecular alterations in male insulinopenic diabetic mice are not completely corrected by insulin. Endocrinology 2016;157:536-47.
Edgar RS, Stangherlin A, Nagy AD, Nicoll MP, Efstathiou S, O’Neill JS, Reddy AB. Cell autonomous regulation of herpes and influenza virus infection by the circadian clock. Proc Natl Acad Sci USA. 2016;113:10085-90. *
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