Publications - Wellcome-MRC Institute of Metabolic Science

Primary Research Publications

2021 | 2020 | 2019 | 2018 | 2017 | 2016 | Older

2022

Cacciottolo TM, Henning E, Keogh JM, Bel Lassen P, Lawler K, Bounds R, Ahmed R, Perdikari A, Mendes de Oliveira E, Smith M, Godfrey EM, Johnson E, Hodson L, Clément K, van der Klaauw AA, Farooqi IS. Obesity due to Steroid Receptor Coactivator-1 deficiency is associated with endocrine and metabolic abnormalities. J Clin Endocrinol Metab. 2022 Feb 8:dgac067. doi: 10.1210/clinem/dgac067. PMID: 35137184
Calejman CM, Doxsey WG, Fazakerley DJ, Guertin DA. Integrating adipocyte insulin signaling and metabolism in the multi-omics era. Trends Biochem Sci. 2022 Mar 15:S0968-0004(22)00050-0. doi: 10.1016/j.tibs.2022.02.009. PMID:35304047
Campbell JE, Beaudry JL, Svendsen B, Baggio LL, Gordon AN, Ussher JR, Wong CK, Gribble FM, D’Alessio DA, Reimann F, Drucker DJ. The GIPR is Predominantly Localized to Non-Adipocyte Cell Types Within White Adipose Tissue. Diabetes. 2022 Feb 22:db211166. doi: 10.2337/db21-1166.PMID: 35192688
Dennison RA, Griffin SJ, Usher-Smith JA, Fox RA, Aiken CE, Meek CL. “Post-GDM support would be really good for mothers”: A qualitative interview study exploring how to support a healthy diet and physical activity after gestational diabetes. PLoS One. 2022 Jan 21;17(1):eo262852. doi: 10.1371/journal.pone.0262852. PMID:35061856 PMCID:PMC8782419
Fazakerley DJ, Koumanov F, Holman GD. GLUT4 On the move. Biochem J. 2022 Feb 11;479(3):445-462. doi: 10.1042/BCJ20210073. PMID:35147164 PMCID:PMC8883492
Furse S, Fernandez-Twinn DS, Beeson JH, Chiarugi D, Ozanne SE, Koulman A. A mouse model of gestational diabetes shows dysregulated lipid metabolism post-weaning, after return to euglycaemia. Nutr Diabetes. 2022 Feb 15;12(1):8. doi: 10.1038/s41387-022-00185-4. PMID: 35169132 PMCID: PMC8847647
Furse S, Watkins AJ, Williams HEL, Snowden SG, Chiarugi D, Koulman A. Paternal nutritional programming of lipid metabolism is propagated through sperm and seminal plasma. Metabolomics. 2022 Feb 10;18(2):13. doi: 10.1007/s11306-022-01869-9. PMID:35141784 PMCID: PMC8828597
Glasgow C, Lau EYC, Aloj L, Harper I, Cheow H, Das T, Berman L, Powlson AS, Bashari W, Challis BG, Marker A, Moyle P, Mohamed I, Schoenmakers N, Broomfield J, Oddy S, Moran C, Gurnell M, Jani P, Masterson L, Fish B, Casey RT. An approach to a patient with primary hyperparathyroidism and a suspected ectopic parathyroid adenoma. J Clin Endocrinol Metab. 2022 Feb 12;dgac024. doi:10.1210/clinem/dgac024.PMID: 35150267
Hall KD, Farooqi IS, Friedman JM, Klein S, Loos RJF, Mangelsdorf DJ, O’Rahilly S, Ravussin E, Redman LM, Ryan DH, Speakman JR, Tobias DK. The energy balance model of obesity: beyond calories in, calories out. Am J Clin Nutr. 2022 Feb 4:nqac031. doi: 10.1093/ajcn/nqac031. PMID:35134825
Hufnagel A, Dearden L, Fernandez-Twinn DS, Ozanne SE. Programming of cardio metabolic health: the role of maternal and fetal hyperinsulinaemia. J Endocrinol. 2022 Mar 1;JOE-21-0332. doi: 10.1530/JOE-21-0332. PMID: 35258482
Mann JP, Jenkins B, Furse S, Snowden SG, Alisi A, Draijer LG, Karnebeek K, Kelly DA, Koot BG, Mosca A, Salvestrini C, van Mourik I, Vreugdenhil A, Zilbauer M, Koulman A; EU-PNAFLD investigators^. Comparison of the Lipidomic Signature of Fatty Liver in Children and Adults: A Cross-Sectional Study. J Pediatr Gastroenterol Nutr. 2022 Feb 21. doi: 10.1097/MPG.0000000000003418. PMID:35185113
Meek CL, Oram RA, McDonald TJ, Feig DS, Hattersley AT, Murphy HR. Response to Comment on Meek et al. Reappearance of C-Peptide During the Third Trimester in Type 1 Diabetes Pregnancy: Pancreatic Regeneration or Fetal Hyperinsulinism? Diabetes Care 2021;44:1826-1834. Diabetes Care. 2022 Feb 1;45(2):e43-e44. doi: 10.2337/dci21-0054. PMID:35050370
Menzies-Gow A, Kreindler J, Katial R, Gurnell M. Adrenal insufficiency in patients taking benralizumab as corticosteroid sparing therapy – Authors’ reply. Lancet Respir Med. 2022 Jan;10(1):e8.doi: 10.1016/S2213-2600(21)00489-6. PMID: 34762847
Merkle FT, Ghosh S, Genovese G, Handsaker RE, Kashin S, Meyer D, Karczewski KJ, O’Dushlaine C, Pato C, Pato M, MacArthur DG, McCarroll SA, Eggan K. Whole-genome analysis of human embryonic stem cells enables rational line selection based on genetic variation. Cell Stem Cell. 2022 Mar 3;29(3):472-486.e7. doi: 10.1016/j.stem.2022.01.011. PMID:35176222 PMCID:PMC8900618
Pantaleao LC, Inzani I, Furse S, Loche E, Hufnagel A, Ashmore T, Blackmore HL, Jenkins B, Carpenter AAM, Wilczynska A, Bushell M, Koulman A, Fernandez-Twinn DS, Ozanne SE. Maternal diet-induced obesity during pregnancy alters lipid supply to mouse E18.5 fetuses and changes the cardiac tissue lipidome in a sex-dependent manner. Elife. 2022 Jan 13;11:e69078. doi: 10.7554/eLife.69078. PMID:35025731
Perdikari A, Cacciottolo T, Henning E, Mendes de Oliveira E, Keogh JM, Farooqi IS. Visualization of sympathetic neural innervation in human white adipose tissue. Open Biol. 2022 Mar;12(3):210345. doi: 10.1098/rsob.210345. PMID:35291877 PMCID:PMC8924755
Putt O, Westacott R, Sam AH, Gurnell M, Brown CA. Using very short answer errors to guide teaching. Clin Teach. 2022 Apr;19(2):100-105. doi: 10.1111/tct.13458. PMID: 35078276
Seyres D, Cabassi A, Lambourne JJ, Burden F, Farrow S, McKinney H, Batista J, Kempster C, Pietzner M, Slingsby O, Cao TH, Quinn PA, Stefanucci L, Sims MC, Rehnstrom K, Adams CL, Frary A, Ergüener B, Kreuzhuber R, Mocciaro G, D’Amore S, Koulman A, Grassi L, Griffin JL, Ng LL, Park A, Savage DB, Langenberg C, Bock C, Downes K, Wareham NJ, Allison M, Vacca M, Kirk PDW, Frontini M.Transcriptional, epigenetic and metabolic signatures in cardiometabolic syndrome defined by extreme phenotypes. Clin Epigenetics. 2022 Mar 12;14(1):39. doi: 10.1186/s13148-022-01257-z. PMID: 35279219
Veprik A, Denwood G, Liu D, Bany Bakar R, Morfin V, McHugh K, Tebeka NN, Vetterli L, Yonova-Doing E, Gribble F, Reimann F, Hoehn KL, Hemsley PA, Ahnfelt-Rønne J, Rorsman P, Zhang Q, de Wet H, Cantley J. Acetyl-CoA-carboxylase 1 (ACC1) plays a critical role in glucagon secretion. Commun Biol. 2022 Mar 18;5(1):238. doi: 10.1038/s42003-022-03170-w. PMID:35304577
Ware J, Allen JM, Boughton CK, Wilinska ME, Hartnell S, Thankamony A, de Beaufort C, Schierloh U, Fröhlich-Reiterer E, Mader JK, Kapellen TM, Rami-Merhar B, Tauschmann M, Nagl K, Hofer SE, Campbell FM, Yong J, Hood KK, Lawton J, Roze S, Sibayan J, Bocchino LE, Kollman C, Hovorka R; KidsAP Consortium. Randomized Trial of Closed-Loop Control in Very Young Children with Type 1 Diabetes. N Engl J Med. 2022 Jan 20;386(3):209-219. doi: 10.1056/NEJMoa2111673. PMID:35045227
Ware J, Boughton CK, Allen JM, Wilinska ME, Tauschmann M, Denvir L, Thankamony A, Campbell FM, Wadwa RP, Buckingham BA, Davis N, DiMeglio LA, Mauras N, Besser REJ, Ghatak A, Weinzimer SA, Hood KK, Fox DS, Kanapka L, Kollman C, Sibayan J, Beck RW, Hovorka R; DAN05 Consortium. Cambridge hybrid closed-loop algorithm in children and adolescents with type 1 diabetes: a multicentre 6-month randomised controlled trial. Lancet Digit Health. 2022 Mar 7:S2589-7500(22)00020-6. doi: 10.1016/S2589-7500(22)00020-6. PMID:35272971
Westwater ML, Murley AG, Diederen KMJ, Carpenter TA, Ziauddeen H, Fletcher PC. Characterizing cerebral metabolite profiles in anorexia and bulimia nervosa and their associations with habitual behavior. Transl Psychiatry. 2022 Mar 15;12(1):103. doi: 10.1038/s41398-022-01872-7. PMID:35292626

2021

100,00 Genomes Project Pilot Investigators, Smedley D, Smith KR, Martin A, Thomas EA, McDonagh EM, Cipriani V, Ellingford JM, Arno G, Tucci A, Vandrovcova J, Chan G, Willliams HJ, Ratnaike T, Wei W, Stirrups K, Ibanez K, Moutsiansas L, Wielscher M, Need A, Barnes MR, Vestito L, Buchanan J, Wordsworth S, Ashford S, Rehmstrom K, Li E, Fuller G, Twiss P, Spasic-boskovic O, Halsall S, Floto RA, Poole K, Wagner A, Mehta SG, Gurnell M, Burrows N, James R, Penkett C, Dewhurst E, Graf S, Mapeta R, Kasanicki M, Haworth A, Savage H, Babcock M, Reese MG Bale M, Baple E, Boustred C, Brittain H, de Burca A, Bleda M, Devereau A, Halai D, Haraldsdottir E, Hyder Z, Kasperaviciute D, Patch C, Polychronopoulos D, Matchan A, Sultana R, Ryten M, Tavares ALT, Tregidgo C, Turnbull C, Welland M, Wood S, Snow C, Williams E, Leigh S, Foulger RE, Daugherty LC, Niblock O, Leong IUS, Wright CF, Davies J, Crichton C, Welch J, Woods K, Abulhoul L, Aurora P, Bockenhauer D, Broomfield A, Cleary MA, Lam T, Dattani M, Footitt E, Ganesan V, Grunewald S, Compeyrot-Lacassagne S, Muntoni F, Pilkington C, Quinlivan R, Thapar N, Wallis C, Wedderburn LR, Worth A, Bueser T, Compton C, Deshpande C, Fassihi H, Haque E, Izatt L, Josifova D, Mohammed S, Robert L, Rose S, Ruddy D, Sarkany R, Say G, Shaw AC, Wolejko A, Habib B, Burs G, Hunter S, Grocock RJ, Humphray SJ, Robinson PN, Haendel M, Simpson MA, Banka S, Clayton-Smith J, Douzgou S, Hall G, Thomas HB, O’Keefe RT, Michaelides M, Moore AT, Malska S, Pontikos N, Browning AC, Straub V, Gorman GS, Horvath R, Quinton R, Schaefer AM, Yu-Wai-Man P, Turnbull DM, McFarland R, Taylor RW, O’Connor E, Yip J, Newland K, Morris HR, Polke J, Wood NW, Campbell C, Camps C, Gibson K, Koelling N, Lester T, Nemeth AH, Palles C, Patel S, Roy NBA, Sen A, Taylor J, Cacheiro P, Jacobsen JO, Seaby EG, Davison V, Chitty L, Douglas A, Naresh K, McMullan D, Ellard S, Temple IK, Mumford AD, Wilson G, Beales P, Bitner-Glindzica M, Black G, Bradley JR, Brennnan P, Burn J, Chinnery PF, Elliott P, Flinter F, Houlden H, Irving M, Newman W, Rahman S, Sayer JA, Taylor JC, Webster AR, Wilkie AOM, Ouwehand WH, Raymond FL, Chisholm J, Hill S, Bentley D, Scott RH, Fowler T, Rendon A,Caulfield M. 100,000 Genomes Pilot on Rare-Disease Diagnosis in Health Preliminary Report. N Engl J Med. 2021 Nov 11;385(20):1868-1880. doi:10.1056/NEJMoa2035790. PMID:34758253
Agrawal N, Lawler K, Davidson CM, Keogh JM, Legg R; INTERVAL, Barroso I, Farooqi IS, Brand AH. Predicting novel candidate human obesity genes and their site of action by systematic functional screening in Drosophila. PLoS Biol. 2021 Nov 8;19(11):e3001255. doi: 10.1371/journal.pbio.3001255. PMID:34748544 PMCID:PMC8575313
Ahmed RM, Tse Ny, Chen Y, Henning E, Hodges JR, Kiernan MC, Irish M, Farooqi IS, Piguet O. Neural correlates of fat preference in frontotemporal dementia: translating insights from the obesity literature. Ann Clin Transl Neurol. 2021 Jun;8(6):1318-1329. doi: 10.1002/acn.51369. PMID:33973740
Andrade S, Morais T, Sandovici I, Seabra AL, Constância M, Monteiro MP. Adipose Tissue Epigenetic Profile in Obesity-Related Dysglycemia – A Systematic Review. Front Endocrinol (Lausanne). 2021 Jun 29;12:681649. doi: 10.3389/fendo.2021.681649. PMID:34290669 PMCID:PMC8288106
Angiolini E, Sandovici I, Coan PM, Burton GJ, Sibley CP, Fowden AL, Constância M. Deletion of the Imprinted Phlda2 Gene Increases Placental Passive Permeability in the Mouse. Genes (Basel). 2021 Apr 25;12(5):639. doi: 10.3390/genes12050639. PMID:33922969 PMCID:PMC8146920
Artero-Castro A, Long K, Bassett A, Avila-Fernandez A, Corton M, Vidal-Puig A, Jendelova P, Rodriguez-Jimenez FJ, Clemente E, Ayuso C, Slaven E, Gene Correction Recovers Phagocytosis in Retinal Pigment Epithelium Derived from Retinitis Pigmentosa-Human-Induced Pluripotent Stem Cells. Int J Mol Sci. 2021 Feb 20;22(4):2092. doi: 10.3390/ijms22042092. PMID:33672445 PMCID:PMC7923278
Asami M, Lam BYH, Ma MK, Rainbow K, Braun S, VerMilyea MD, Yeo GSH, Perry ACF. Human embryonic genome activation initiates at the one-cell stage. Cell Stem Cell. 2021 Dec 17;S1934-5909(21)00484-7. doi: 10.1016/j.stem.2021.11.012. PMID:34936886
Ayer A, Fazakerley DJ, James DE, Stocker R. The role of mitochondrial reactive oxygen species in insulin resistance. Free Radic Biol Med. 2021 Nov 11:S0891-5849(21)00794-2. doi: 10.1016/j.freeradbiomed.2021.11.007. PMID:34775001
Ayer A, Fazakerley DJ, Suarna C, Maghzal GJ, Sheipouri D, Lee KJ, Bradley MC, Fernández-Del-Rio L, Tumanov S, Kong SM, van der Veen JN, Yang A, Ho JWK, Clarke SG, James DE, Dawes IW, Vance DE, Clarke CF, Jacobs RL, Stocker R. Genetic screening reveals phospholipid metabolism as a key regulator of the biosynthesis of the redox-active lipid coenzyme Q. Redox Biol. 2021 Sep 8;46:102127. doi: 10.1016/j.redox.2021.102127. PMID:34521065 PMCID:PMC8435697
Azzu V, Vacca M, Kamzolas I, Hall Z, Leslie J, Carobbio S, Virtue S, Virtue S, Davies SE, Lukasik A, Dale M, Bohlooly-Y M, Acharjee A, Linden D, Bidault G, Petsalaki E, Griffin JL, Oakley F, Allison ME, Vidal-Puig A. Suppression of insulin-induced gene 1 (INSIG1) function promotes hepatic lipid remodelling and restrains NASH progression. Mol Metab. 2021 Mar 12:101210. doi: 10.1016/jmolmet.2021.101210. PMID:33722690
Bashari WA, Senanayake R, MacFarlane J, Gillett D, Powlson AS, Kolias A, Mannion RJ, Koulouri O, Gurnell M. Using Molecular Imaging to Enhance Decision Making in the Management of Pituitary Adenomas. J Nucl Med. 2021 Jul;62(Suppl 2):57S-62S. doi: 10.2967/jnumed.120.251546. PMID:34230075
Beardsall K, Thomson L, Guy C, Bond S, Allison A, Pantaleo B, Petrou S, Kim S, Dunger D, Hovorka R. Continuous glucose monitoring in extremely preterm infants in intensive care: the REACT RCT and pilot study of ‘closed-loop’ technology. Southampton (UK): NIHR Journals Library; 2021 Oct. PMID:34723449
Beardsall K, Thomason L, Guy C, Iglesias-Platas I, van Weissenbruch MM, Bond S, Allison A, Kim S, Petrou S, Pantaleo B, Hovorka R, Dunger D; REACT collaborative. Real-time continuous glucose monitoring in preterm infants (REACT): an international, open-label, randomised controlled trial. Lancet Child Adolesc Health. 2021 Feb 9:S2352-4642(20)30367-9. doi: 10.1016/S2352(20)30367-9. PMID:33577770
Bidault G, Virtue S, Petkevicius K, Jolin HE, Dugourd A, Guénantin AC, Leggat J, Mahler-Araujo B, Lam BYH, Ma MK, Dale M, Carobbio S, Kaser A, Fallon PG, Saez-Rodriguez J, McKenzie ANJ, Vidal-Puig A. SREBP1-induced fatty acid synthesis depletes macrophages antioxidant defences to promote their alternative activation. Nat Metab. 2021 Sep 16. doi: 10.1038/s42255-021-00440-5. PMID:34531575
Biglari N, Gaziano I, Schumacher J, Radermacher J, Paeger L, Klemm P, Chen W, Corneliussen S, Wunderlich CM, Sue M, Vollmar S, Klöckener T, Sotelo-Hitschfeld T, Abbasloo A, Edenhofer F, Reimann F, Gribble FM, Fenselau H, Kloppenburg P, Wunderlich FT, Brüning JC. Functionally distinct POMC-expressing neuron subpopulations in hypothalamus revealed by intersectional targeting. Nat Neurosci. 2021 May 17. doi: 10.1038/s41593-021-00854-0. PMID:34002087
Billing LJ, Larraufie P, Lewis J, Leiter A, Li J, Lam B, Yeo GS, Goldspink DA, Kay RG, Gribble FM, Reimann F. Corrigendum to single cell transcriptomic profiling of large intestinal enteroendocrine cells in mice – Identification of selective stimuli for insulin-like peptide-5 and glucagon-like peptide-1 co-expressing cells (Molecular metabolism. 2019 Nov;29:158-169). Mol Metab. 2022 Jan;55:101399. doi: 10.1016/j.molmet.2021.101399. PMID:34863700 PMCID:PMC8766775
Bertozzi TM, Becker JL, Blake GET, Bansal A, Nguyen DK, Fernandez-Twinn DS, Ozanne SE, Bartolomei MS, Simmons RA, Watson ED, Ferguson-Smith AC. Variably methylated retrotransposons are refractory to a range of environmental perturbations. Nat Genet. 2021 Aug;53(8):1233-1242. doi: 10.1038/s41588-021-00898-9. PMID:34326545
Boughton CK, Daly A, Thabit H, Hartnell S, Herzig D, Vogt A, Ruan Y, Wilinska ME, Evans ML, Coll AP, Bally L, Hovorka R. Day-to-day variability of insulin requirements in the inpatient setting: observations during fully closed-loop insulin delivery. Diabetes Obes Metab. 2021 Apr 6. doi: 10.1111/dom.14396. PMID33822461
Boughton CK, Hartnell S, Thabit H, Poettler T, Herzig D, Wilinska ME, Ashcroft NL, Sibayan J, Cohen N, Calhoun P, Bally L, Mader JK, Evans M, Leelarathna L, Hovorka R. Hybrid closed-loop glucose control with faster insulin aspart (Fiasp) compared with standard insulin aspart in adults with type 1 diabetes: a double-blind, multicentre, multinational, randomised, crossover study. Diabetes Obes Metab. 2021 Feb 19. doi:10.1111/dom.14355. PMID:33606901
Boughton CK, Hovorka R. Correction to: New closed-loop insulin systems. Diabetologia. 2021 Mar 22. doi: 10.1007/s00125-021-05443-1. PMID:33751132
Boughton CK, Hovorka R. Can exenatide flatten the post-prandial glucose curve in type 1 diabetes? Ann Transl Med. 2020 Nov;8(22):1535. doi: 10.21037/atm-20-3654. PMID:33313280 PMCID:PMC7729374
Boughton CK, Hovorka R. New closed-loop insulin systems. Diabetologia. 2021 Feb 6. doi: 10.1007/s00125-021-05391-w. PMID:33550442
Boughton CK, Tripyla A, Hartnell S, Daly A, Herzig D, Wilinska ME, Czerlau C, Fry A, Bally L, Hovorka R. Fully automated closed-loop glucose control compared with standard insulin therapy in adults with type 2 diabetes requiring dialysis: an open-label, randomized crossover trial. Nat Med. 2021 Aug;27(8):1471-1476. doi: 10.1038/s41591-021-01453-z. PMID:34349267 PMCID:PMC8363503
Boughton CK, Tripyla A, Hartnell S, Daly A, Herzig D, Wilinska ME, Czerlau C, Fry A, Bally L, Hovorka R. Publisher Correction: Fully automated closed-loop glucose control compared with standard insulin therapy in adults with type 2 diabetes requiring dialysis: an open-label, randomized crossover trial. Nat Med. 2021 Sep 16. doi: 10.1038/s41591-021-01504-5. PMID:34531573
Bowker N, Hansford R, Burgess S, Foley CN, Auyeung VPW, Erzurumluoglu AM, Stewart ID, Wheeler E, Pietzner M, Gribble F, Reimann F, Bhatnagar P, Coghlan MP, Wareham NJ, Langenberg C. Genetically Predicted Glucose-Dependent Insulinotropic Polypeptide (Gip) Levels and Cardiovascular Disease Risk are Driven by Distinct Causal Variants in the Gipr Region. Diabetes. 2021 Aug 23:db210103. doi: 10.2337/db21-0103. PMID:34426508
Brierley DI, Holt MK, Singh A, de Araujo A, McDougle M, Vergara M, Afaghani MH, Lee SJ, Scott K, Maske C, Langhans W, Krause E, de Kloet A, Gribble FM, Reimann F, Rinaman L, de Lartigue G, Trapp S. Central and peripheral GLP-1 systems independently suppress eating. Nat Metab. 2021 Feb;3(2):258-273. doi: 10.1038/s42255-021-00344-4. PMID: 33589843 PMCID:PMC7116821
Brocklebank LA, Blackwell AKM, Marteau TM, Hollands GJ, Fletcher PC, De-Loyde K, Morris RW, Pilling MA, Pechey R, Maynard OM, Attwood AS, Munafò MR. Straight-sided beer and cider glasses to reduce alcohol sales for on-site consumption: A randomised crossover trial in bars. Soc Sci Med. 2021 Jun;278:113911.doi:10.1016/j.socscimed.2021.113911. PMID:33962320 PMCID:PMC8146727
Brouwers B, Mendes de Oliveira E, Marti-Solano M, Monteiro FBF, Laurin SA, Keogh JM, Henning E, Bounds R, Daly CA, Houston S, Ayinampudi V, Wasiluk N, Clarke D, Plouffe B, Bouvier M, Babu MM, Farooqi IS, Mokrosiński J. Human MC4R variants affect endocytosis, trafficking and dimerization revealing multiple cellularmechanisms involved in weight regulation. Cell Reports, 23 March 2021, 34, 108862. PMID: 33761344 PMCID:PMC7994375
Buecker C, Merkle FT. Science shines in a new virtual SY-Stem. Development. 2021 Jun 15;148(12):dev188367. doi: 10.1242/dev.188367. PMID:34170290
Burke LK, Darwish T, Cavanaugh AR, Virtue S, Roth E, Morro J, Liu SM, Xia J, Dalley JW, Burling K, Chua S, Vidal-Puig T, Schwartz GJ, Blouet C. mTORC1 in AGRP neurons integrates exteroceptive and interoceptive food-related cues in the modulation of adaptive energy expenditure in mice. Elife. 2017 May 23;6:e22848. doi: 10.7554/eLife.22848. PMID:28532548 PMCID:PMC5441868
Camm EJ, Cross CM, Kane AD, Tarry-Adkins JL, Ozanne SE, Giussani DA. Maternal antioxidant treatment protects adult offspring against memory loss and hippocampal atrophy in a rodent model of developmental hypoxia. FASEB J. 2021 May;35(5):e21477. doi: 10.1096/fj.202002557RR. PMID:33891326
Carobbio S, Guenantin AC, Bahri M, Rodriguez-Fdez S, Hong F Kamzolas I, Samuelson I, Lond K, Awad S, Lukovic D, Erceg S, Bassett A, Mendjan S, Vallier L, Rosen BS, Chiarugi D, Vidal-Puig A. Unravelling the development roadmap towards human brown adipose tissue. Stem Cell Reports. 2021 Feb 6;S2213 6711(21)00043-6. doi: 10.1016/j.stemcr.2021.01.013. PMID:33606988 PMCID:PMC7940445
Chen NS, Boughton CK, Hartnell S, Fuchs J, Allen JM, Willinska ME, Thankamony A, de Beaufort C, Campbell FM, Fröhlich-Reiterer E, Hofer SE, Kapellen TM, Rami-Merhar B, Ghatak A, Randell TL, Besser REJ, Elleri D, Trevelyan N, Denvir L, Davis N, Gurnell E, Lindsay R, Morris D, Scott EM, Bally L, Thabit H, Leelarathna L, Evans ML, Murphy HR, Mader JK, Hovorka R; AiDAPT, AP@home04, CLOuD, DAN05, DAN06, and KidsAP consortia. User Engagement With the CamAPS FX Hybrid Closed-Loop App According to Age and User Characteristics. Diabetes Care. 2021 May 21;dc202762. doi: 10.2337/dc20-2762. PMID:34021021
Chen W, Tumanov S, Fazakerley DJ, Cantley J, James DE, Dunn LL, Shaik T, Suarna C, Stocker R. Bilirubin deficiency renders mice susceptible to hepatic steatosis in the absence of insulin resistance. Redox Biol. 2021 Nov;47:102152. doi: 10.1016/j.redox.2021.102152. PMID:34610553 PMCID:PMC8498001
Choi RJ, Mohamad Zobir SZ, Alexander-Dann B, Sharma N, Ma MKL, Lam BYH, Yeo GSH, Zhang W, Fan TP, Bender A. Combination of Ginsenosides Rb2 and Rg3 Promotes Angiogenic Phenotype of Human Endothelial Cells via PI3K/Akt and MAPK/ERK Pathways. Front Pharmacol. 2021 Feb 10;12:618773. doi: 10.3389/fphar.2021.618773. PMID:33643049 PMCID:PMC7902932
Chondronikola M, Bartelt A, Vidal-Puig A, Virtanen KA. Editorial: Brown Adipose Tissue: From Heat Production in Rodents to Metabolic Health in Humans. Front Endocrinol (Lausanne). 2021 Jul 26;12:739065. doi: 10.3389/fendo.2021.739065. eCollection 2021. PMID:34381425 PMCID:PMC8350568
Cimino I, Kim H, Tung YCL, Pedersen K, Rimmington D, Tadross JA, Kohnke SN, Neves-Costa A, Barros A, Joaquim S, Bennett D, Melvin A, Lockhart SM, Rostron AJ, Scott J, Liu H, Burling K, Barker P, Clatworthy MR, Lee EC, Simpson AJ, Yeo GSH, Moita LF, Bence KK, Jørgensen SB, Coll AP, Breen DM, O’Rahilly S. Activation of the hypothalamic-pituitary-adrenal axis by exogenous and endogenous GDF15. Proc Natl Acad Sci U S A. 2021 Jul 6;118(27):e2106868118. doi: 10.1073/pnas.2106868118. PMID:34187898 PMCID:PMC8271778
Cimino I, Rimmington D, Tung YCL, Lawler K, Larraufie P, Kay RG, Virtue S, Lam BYH, Fagnocchi L, Ma MKL, Saudek V, Zvetkova I, Vidal-Puig A, Yeo GSH, Farooqi IS, Pospisilik JA, Gribble FM, Reimann F, O’Rahilly S, Coll AP. Murine neuronatin deficiency is associated with a hypervariable food intake and bimodal obesity. Sci Rep. 2021 Sep 2;11(1):17571. doi: 10.1038/s41598-021-96278-8. PMID:34475432 PMCID:PMC8413370
Corrales P, Vidal-Puig A, Medina-Gómez G. Obesity and pregnancy, the perfect metabolic storm. Eur J Clin Nutr. 2021 Apr 28. doi: 10.1038/s41430-021-00914-5. PMID:33911209
Daly A, Hovorka R. Technology in the management of type 2 diabetes: Present status and future prospects. Diabetes Obes Metab. 2021 May 5. doi: 10.1111/dom.14418. PMID:33950566
de Beaufort C, Pit-Ten Cate IM, Schierloh U, Cohen N, Boughton CK, Tauschmann M, Allen JM, Nagl K, Fritsch M, Yong J, Metcalfe E, Schaeffer D, Fichelle M, Thiele AG, Abt D, Faninger K, Mader JK, Slegtenhorst S, Ashcroft N, Wilinska ME, Sibayan J, Kollman C, Hofer SE, Fröhlich-Reiterer E, Kapellen TM, Acerini CL, Campbell F, Rami-Merhar B, Hovorka R. Psychological Well-Being of Parents of Very Young Children With Type 1 Diabetes – Baseline Assessment. Front Endocrinol (Lausanne). 2021 Aug 12;12:721028. doi: 10.3389/fendo.2021.721028. eCollection 2021. PMID:34456876 PMCID:PMC8397439
Dennison RA, Meek CL, Usher-Smith JA, Fox RA, Aiken CE, Griffin SJ. ‘Oh, I’ve got an appointment’: A qualitative interview study exploring how to support attendance at diabetes screening after gestational diabetes. Diabet Med. 2021 Oct;38(10):e14650. doi: 10.1111/dme.14650. PMID:34268798
Di Cicco E, Moran C, Visser WE, Nappi A, Schoenmakers E, Todd P, Lyons G, Dattani M, Ambrosio R, Parisi S, Salvatore D, Chatterjee VK, Dentice M. Germ line mutations in the thyroid hormone receptor alpha gene predispose to cutaneous tags and melanocytic nevi. Thyroid. 2021 Jan 28. doi: 10.1089/thy.2020.0391. PMID:33509032
Ding Q, Edwards MM, Wang N, Zhu X, Bracci AN, Hulke ML, Hu Y, Tong Y, Hsiao J, Charvet CJ, Ghosh S, Handsaker RE, Eggan K, Merkle FT, Gerhardt J, Egli D, Clark AG, Koren A. The genetic architecture of DNA replication timing in human pluripotent stem cells. Nat Commun. 2021 Nov 19;12(1):6746. doi: 10.1038/s41467-021-27115-9. PMID:34799581
Dolezalova N, Gruszczyk A, Barkan K, Gamble JA, Galvin S, Moreth T, O’Holleran K, Mahbubani KT, Higgins JA, Gribble FM, Reimann F, Surmacki J, Andrews S, Casey JJ, Pampaloni F, Murphy MP, Ladds G, Slater NKH, Saeb-Parsy K. Accelerating cryoprotectant diffusion kinetics improves cryopreservation of pancreatic islets. Sci Rep. 2021 May 17;11(1):10418. doi: 10.1038/s41598-021-89853-6. PMID:34001961 PMCID:PMC8129116
Dowsett GKC, Lam BYH, Tadross JA, Cimino I, Rimmington D, Coll AP, Polex-Wolf J, Knudsen LB, Pyke C, Yeo GSH. A survey of the mouse hindbrain in the fed and fasted state using single-nucleus RNA sequencing. Mol Metab. 2021 May 4;101240. doi: 10.1016/j.molmet.2021.101240. PMID:33962048
Durgia H, Nicholas AK, Schoenmakers E, Dickens JA, Halanaik D, Sahoo J, Kamalanathan S, Schoenmakers N. Brief Report: A Novel Sodium/Iodide Symporter Mutation, S356F, Causing Congenital Hypothyroidism. Thyroid. 2021 Nov 22. doi: 10.1089/thy.2021.0478. PMID:34806438
Fabricius TW, Verhulst CEM, Kristensen PL, Tack CJ, McCrimmon RJ, Heller S, Evans ML, Amiel SA, Pieber TR, de Galan BE, Pedersen-Bjergaard U; Hypo-RESOLVE consortium. Hyperinsulinaemic-hypoglycaemic glucose clamps in human research: a systematic review of the literature. Diabetologia. 2021 Feb 10. doi: 10.1007/s00125-020-05361-8. PMID:33566134
Farooqi IS. Monogenic human obesity syndromes. Handb Clin Neurol. 2021;181:301-310. doi: 10.1016/B978-0-12-820683-6.00022-1. PMID:34238466
Finnemann JJS, Plaisted-Grant K, Moore J, Teufel C, Fletcher PC. Low-level, prediction-based sensory and motor processes are unimpaired in Autism. Neuropsychologia. 2021 Mar 29;156:107835. doi: 10.1016/j.neuropsychologia.2021.107835. PMID:33794277
Foreman RE, George AL, Reimann F, Gribble FM, Kay RG. Peptidomics: A Review of Clinical Applications and Methodologies. J Proteome Res. 2021 Jul 16. doi: 10.1021/acs.jproteome.1c00295. PMID:34270237
Fox RA, Patient CJ, Aiken AR, Meek CL, Aiken CE. Temporal variations in maternal treatment requirements and early neonatal outcomes in patients with gestational diabetes. Diabet Med. 2021 May 8:e14596. doi: 10.1111/dme.14596. PMID:33963609
Fuchs J, Allen JM, Boughton CK, Wilinska ME, Thankamony A, de Beaufort C, Campbell F, Yong J, Froehlich-Reiterer E, Mader JK, Hofer SE, Kapellen TM, Rami-Merhar B, Tauschmann M, Hood K, Kimbell B, Lawton J, Roze S, Sibayan J, Cohen N, Hovorka R; KidsAP Consortium. Assessing the efficacy, safety and utility of closed-loop insulin delivery compared with sensor-augmented pump therapy in very young children with type 1 diabetes (KidsAP02 study): an open-label, multicentre, multinational, randomised cross-over study protocol. BMJ Open. 2021 Feb 12;11(2):e042790. doi: 10.1136/bmjopen-2020-042790. PMID: 33579766 PMC7883854
Fuchs J, Hovorka R. Benefits and Challenges of Current Closed-Loop Technologies in Children and Young People With Type 1 Diabetes. Front Pediatr. 2021 Apr 30;9:679484. doi: 10.3389/fped.2021.679484. eCollection 2021. Front Pediatr. 2021 Apr 30;9:679484. doi: 10.3389/fped.2021.679484. PMID:33996702 PMCID:PMC8119627
Furse S, Fernandez-Twinn DS, Chiarugi D, Koulman A, Ozanne SE. Lipid Metabolism Is Dysregulated before, during and after Pregnancy in a Mouse Model of Gestational Diabetes. Int J Mol Sci. 2021 Jul 12;22(14):7452. doi: 10.3390/ijms22147452. PMID:34299070
Furse S, Watkins AJ, Hojat N, Smith J, Williams HEL, Chiarugi D, Koulman A. Lipid Traffic Analysis reveals the impact of high paternal carbohydrate intake on offsprings’ lipid metabolism. Commun Biol. 2021 Feb 5;4(1):163. doi: 10.1038/s42003-021-01686-1. PMID:33547386 PMCID:PMC7864968
Furse S, Williams HEL, Watkins AJ, Virtue S, Vidal-Puig A, Amarsi R, Charalambous M, Koulman A. A pipeline for making 31 P NMR accessible for small- and large-scale lipidomics studies. Anal Bioanal Chem. 2021 Jul 12. doi: 10.1007/s00216-021-03430-4. PMID:34254158
Gage MC, Harrington D, Brierley GV, Freathy RM, Gabriel BM, Gibson R, McNeilly AD, Meek CL, Roberts LD. Challenges and solutions for diabetes early career researchers in the COVID-19 recovery: Perspectives of the Diabetes UK Innovators in Diabetes. Diabet Med. 2021 Sep 25;e14698. doi: 10.1111/dme.14698. PMID:34562338
Gallant J, Chan K, Green TJ, Wieringa FT, Leemaqz S, Ngik R, Measelle JR, Baldwin DA, Borath M, Sophonneary P, Yelland LN, Hampel D, Shahab-Ferdows S, Allen LH, Jones KS, Koulman A, Parkington DA, Meadows SR, Kroeun H, Whitfield KC. Low-dose thiamine supplementation of lactating Cambodian mothers improves human milk thiamine concentrations: a randomized controlled trial. Am J Clin Nutr. 2021 Apr 7;nqab052. doi: 10.1093/ajcn/nqab052. PMID:33829271
Galvin SG, Kay RG, Foreman R, Larraufie P, Meek CL, Biggs E, Ravn P, Jermutus L, Reimann F, Gribble FM. The Human and Mouse Islet Peptidome: Effects of Obesity and Type 2 Diabetes, and Assessment of Intraislet Production of Glucagon-like Peptide-1. J Proteome Res. 2021 Sep 3;20(9):4507-4517. doi: 10.1021/acs.jproteome.1c00463. Epub 2021 Aug 23. PMID:34423991 PMCID:PMC8419866
Galvin SG, Larraufie P, Kay RG, Pitt H, Bernard E, McGavigan AK, Brandt H, Hood J, Sheldrake L, Conder S, Atherton-Kemp D, Lu VB, O’Flaherty EAA, Roberts GP, Ämmälä C, Jermutus L, Baker D, Gribble FM, Reimann F. Peptidomics of enteroendocrine cells and characterisation of potential effects of a novel preprogastrin derived-peptide on glucose tolerance in lean mice. Peptides. 2021 Mar 17:170532. doi: 10.1016/j.peptides.2021.170532. PMID:33744371
Gao M, Piernas C, Astbury NM, Hippisley-Cox J, O’Rahilly S, Aveyard P, Jebb SA. Associations between body-mass index and COVID-19 severity in 6·9 million people in England: a prospective, community-based, cohort study. Lancet Diabetes Endocrinol. 2021 Jun;9(6):350-359. doi: 10.1016/S2213-8587(21)00089-9. PMID:33932335 PMCID:PMC8081400
Gillett D, Bashari W, Senanayake R, Marsden D, Koulouri O, MacFarlane J, van der Meulen M, Powlson AS, Mendichovszky IA, Cheow H, Bird N, Kolias A, Mannion R, Gurnell M. Methods of 3D printing models of pituitary tumors. 3D Print Med. 2021 Aug 31;7(1):24. doi: 10.1186/s41205-021-00118-4. PMID:34462823 PMCID:PMC8406959
Gillett D, Marsden D, Ballout S, Attili B, Bird N, Heard S, Gurnell M, Mendichovszky IA, Aloj L. 3D printing 18 F radioactive phantoms for PET imaging. EJNMMI Phys. 2021 Apr 28;8(1):38. doi: 10.1186/s40658-021-00383-6. PMID:33909154 PMCID:PMC8081805
Gonzales GB, Brals D, Sonko B, Sosseh F, Prentice AM, Moore SE, Koulman A. Plasma lipids and growth faltering: A longitudinal cohort study in rural Gambian children. Sci Adv. 2021 Sep 17;7(38):eabj1132. doi: 10.1126/sciadv.abj1132. PMID:34533992
Gribble FM, O’Rahilly S. Obesity therapeutics: The end of the beginning. Cell Metab 2021;33:705-706. doi: 10.1016/j.cmet.2021.03.012. PMID:33826913
Gribble FM, Reimann F. Metabolic Messengers: glucagon-like peptide 1. Nat Metab. 2021 Feb;3(2):142-148. doi: 10.1038/s42255-020-00327-x. PMID: 33432200
Gurnell M, Heaney LG, Price D, Menzies-Gow A. Long-term corticosteroid use, adrenal insufficiency, and the need for steroid-sparing treatment in adult severe asthma. J Intern Med. 2021 Feb 17. doi: 10.1111/joim.13273. PMID:33598993
Guest PC, Ozanne SE. The Worldwide Effort to Develop Vaccines for COVID-19. Adv Exp Med Biol. 2021;1327:215-223. doi: 10.1007/978-3-030-71697-4_18. PMID:34279842
Gupta D, Dowsett GKC, Mani BK, Shankar K, Osborne-Lawrence S, Metzger NP, Lam BYH, Yeo GSH, Zigman JM. High co-expression of the ghrelin and LEAP2 receptor GHSR with pancreatic polypeptide in mouse and human islets. Endocrinology. 2021 Jul 21:bqab148. doi: 10.1210/endocr/bqab148. PMID:34289060
Hamed MO, Barlow AD, Dolezalova N, Khosla S, Sagar A, Gribble FM, Davies S, Murphy MP, Hosgood SA, Nicholson ML, Saeb-Parsy K. Ex vivo normothermic perfusion of isolated segmental porcine bowel: a novel functional model of the small intestine. BJS Open. 2021 Mar 5;5(2):zrab009. doi: 10.1093/bjsopen/zrab009. PMID:33839750 PMCID:PMC8038264
Harding EC, Ba W, Zahir R, Yu X, Yustos R, Hsieh B, Lignos L, Vyssotski AL, Merkle FT, Constandinou TG, Franks NP, Wisden W. Nitric Oxide Synthase Neurons in the Preoptic Hypothalamus Are NREM and REM Sleep-Active and Lower Body Temperature. Front Neurosci. 2021 Oct 14;15:709825. doi: 10.3389/fnins.2021.709825. PMID:34720852 PMCID:PMC8551479
Harno E, Sefton C, Wray JR, Allen TJ, Davies A, Coll AP, White A. Chronic glucocorticoid treatment induces hepatic lipid accumulation and hyperinsulinaemia in part through actions on AgRP neurons. Sci Rep. 2021 Jul 2;11(1):13776. doi: 10.1038/s41598-021-93378-3. PMID:34215821 PMCID:PMC8253818
Harshfield EL, Fauman EB, Stacey D, Paul DS, Ziemek D, Ong RMY, Danesh J, Butterworth AS, Rasheed A, Sattar T, Zameer-Ul-Asar, Saleem I, Hina Z, Ishtiaq U, Qamar N, Mallick NH, Yaqub Z, Saghir T, Rizvi SNH, Memon A, Ishaq M, Rasheed SZ, Memon FU, Jalal A, Abbas S, Frossard P, Saleheen D, Wood AM, Griffin JL, Koulman A. Genome-wide analysis of blood lipid metabolites in over 5000 South Asians reveals biological insights at cardiometabolic disease loci. BMC Med. 2021 Sep 10;19(1):232. doi: 10.1186/s12916-021-02087-1. PMID:34503513 PMCID:PMC8431908
Heeley N, Kirwan P, Darwish T, Arnaud M, Evans ML, Merkle FT, Reimann F, Gribble FM, Blouet C. Rapid sensing of l-leucine by human and murine hypothalamic neurons: Neurochemical and mechanistic insights. Mol Metab. 2018 Apr;10:14-27. doi: 10.1016/j.molmet.2018.01.021. PMID29439854 PMCID:PMC5985239
Ho K, Fleseriu M, Kaiser U, Salvatori R, Brue T, Lopes MB, Kunz P, Molitch M, Camper SA, Gadelha M, Syro LV, Laws E, Reincke M, Nishioka H, Grossman A, Barkan A, Casanueva F, Wass J, Mamelak A, Katznelson L, van der Lely AJ, Radovick S, Bidlingmaier M, Boguszewski M, Bollerslev J, Hoffman AR, Oyesiku N, Raverot G, Ben-Shlomo A, Fowkes R, Shimon I, Fukuoka H, Pereira AM, Greenman Y, Heaney AP, Gurnell M, Johannsson G, Osamura RY, Buchfelder M, Zatelli MC, Korbonits M, Chanson P, Biermasz N, Clemmons DR, Karavitaki N, Bronstein MD, Trainer P, Melmed S. Pituitary Neoplasm Nomenclature Workshop: Does Adenoma Stand the Test of Time? J Endocr Soc. 2021 Feb 9;5(3):bvaa205. doi: 10.1210/jendso/bvaa205. PMID:33604494 PMCID:PMC7874572
Hornigold DC, Roth E, Howard V, Will S, Oldham S, Coghlan MP, Blouet C, Trevaskis JL. A GLP-1:CCK fusion peptide harnesses the synergistic effects on metabolism of CCK-1 and GLP-1 receptor agonism in mice. Appetite. 2018 Aug 1;127:334-340. doi: 10.1016/j.appet.2018.05.131. PMID:29782892 PMCID:PMC6026274
Huang, F.-Y., Sutcliffe, M.P.F. and Grabenhorst, F. (2021). Preferences for nutrients and sensory food qualities identify biological sources of economic values in monkeys. Proc Natl Acad Sci USA. 118(26): e2101954118. doi: 10.1073/pnas.2101954118. PMID: 34155111
Huang-Doran I, Kinzer AB, Jimenez-Linan M, Thackray K, Harris J, Adams CL, de Kerdanet M, Stears A, O’Rahilly S, Savage DB, Gorden P, Brown RJ, Semple RK. Ovarian hyperandrogenism and its response to gonadotropin-releasing hormone analogue therapy in primary severe insulin resistance. J Clin Endocrinol Metab. 2021 Apr 26:dgab275. doi: 10.1210/clinem/dgab275. PMID:33901270
Huang FY, Sutcliffe MPF, Grabenhorst F. Preferences for nutrients and sensory food qualities identify biological sources of economic values in monkeys. Proc Natl Acad Sci U S A. 2021 Jun 29;118(26):e2101954118. doi: 10.1073/pnas.2101954118. PMID:34155111 PMCID:PMC8255786
Huang LO, Rauch A, Mazzaferro E, Preuss M, Carobbio S, Bayrak CS, Chami N, Wang Z, Schick UM, Yang N, Itan Y, Vidal-Puig A, den Hoed M, Mandrup S, Kilpeläinen TO, Loos RJF. Genome-wide discovery of genetic loci that uncouple excess adiposity from its comorbidities. Nat Metab. 2021 Feb;3(2):228-243. doi: 10.1038/s42255-021-00346-2. PMID:33619380
Hufnagel A, Fernandez-Twinn DS, Blackmore HL, Ashmore TJ, Heaton RA, Jenkins B, Koulman A, Hargreaves IP, Aiken CE, Ozanne SE. Maternal but not fetoplacental health can be improved by metformin in a murine diet-induced model of maternal obesity and glucose intolerance. Physiol. 2021 Sep 10. doi: 10.1113/JP281902. PMID:34505282
Im YR, Hunter H, de Gracia Hahn D, Duret A, Cheah Q, Dong J, Fairey M, Hjalmarsson C, Li A, Kai Lim H, McKeown L, Mitrofan CG, Rao R, Utukuri M, Rowe IA, Mann JP. A systematic review of animal models of NAFLD finds high fat, high fructose diets most closely resemble human NAFLD. Hepatology. 2021 May 11. doi: 10.1002/hep.31897. PMID:33973269
Jerber J, Seaton DD, Cuomo ASE, Kumasaka N, Haldane J, Steer J, Patel M, Pearce D, Andersson M, Bonder MJ, Mountjoy E, Ghoussaini M, Lancaster MA; HipSci Consortium, Marioni JC, Merkle FT, Gaffney DJ, Stegle O. Population-scale single-cell RNA-seq profiling across dopaminergic neuron differentiation. Nat Genet. 2021 Mar;53(3):304-312. doi: 10.1038/s41588-021-00801-6. PMID:33664506
Johnson K, Leary PJ, Govaere O, Barter MJ, Charlton SH, Cockell SJ, Tiniakos D, Zatorska M, Bedossa P, Brosnan MJ, Cobbold JF, Ekstedt M, Aithal GP, Clément K, Schattenberg JM, Boursier J, Ratziu V, Bugianesi E, Anstee QM, Daly AK; LITMUS Consortium Investigators. Increased serum miR-193a-5p during non-alcoholic fatty liver disease progression: Diagnostic and mechanistic relevance. JHEP Rep. 2021 Nov 25;4(2):100409. doi: 10.1016/j.jhepr.2021.100409. PMID:35072021 PMCID:PMC8762473
Jones D, De Lucia Rolfe E, Rennie KL, Griep LMO, Kusinski LC, Hughes DJ, Brage S, Ong KK, Beardsall K, Meek CL. Antenatal Determinants of Childhood Obesity in High-Risk Offspring: Protocol for the DiGest Follow-Up Study. Nutrients. 2021 Mar 31;13(4):1156. doi: 10.3390/nu13041156. PMID:33807319 PMC8067255
Kanakis I, Alameddine M, Folkes L, Moxon S, Myrtziou I, Ozanne SE, Peffers MJ, Goljanek-Whysall K, Vasilaki A. Small-RNA Sequencing Reveals Altered Skeletal Muscle microRNAs and snoRNAs Signatures in Weanling Male Offspring from Mouse Dams Fed a Low Protein Diet during Lactation. Cells. 2021 May 11;10(5):1166. doi: 10.3390/cells10051166. PMID:34064819 PMCID:PMC8150574
Kanti V, Puder L, Jahnke I, Krabusch PM, Kottner J, Vogt A, Richter C, Andruck A, Lechner L, Poitou C, Krude H, Gottesdiener K, Clément K, Farooqi IS, Wiegand S, Kühnen P, Blume-Peytavi U. A Melanocortin-4 Receptor Agonist Induces Skin and Hair Pigmentation in Patients with Monogenic Mutations in the Leptin-Melanocortin Pathway. Skin Pharmacol Physiol. 2021 May 31:1-10. doi: 10.1159/000516282. PMID:34058738
Kay RG, Barker P, Burling K, Cohen M, Halsall D, Reimann F, Gribble FM, Semple RK, Church D. Increased C-Peptide Immunoreactivity in Insulin Autoimmune Syndrome (Hirata Disease) Due to High Molecular Weight Proinsulin. Clin Chem. 2021 Jun 1;67(6):854-862. doi: 10.1093/clinchem/hvab043. PMID:34051096 PMCID:PMC8167340
Kearney AL, Norris DM, Ghomlaghi M, Kin Lok Wong M, Humphrey SJ, Carroll L, Yang G, Cooke KC, Yang P, Geddes TA, Shin S, Fazakerley DJ, Nguyen LK, James DE, Burchfield JG. Akt phosphorylates insulin receptor substrate to limit PI3K-mediated PIP3 synthesis. Elife. 2021 Jul 13;10:e66942. doi: 10.7554/eLife.66942. PMID:34253290 PMCID:PMC8277355
Kelly MP, Brayne C, Kinmonth AL, Kriznik N, Ford J, Fletcher PC. Inequalities in mental health: predictive processing and social life. Curr Opin Psychiatry. 2021 Mar 1;34(2):171-176. doi: 10.1097/YCO.0000000000000680. PMID:33394729
Kimbell B, Lawton J, Boughton C, Hovorka R, Rankin D. Parents’ experiences of caring for a young child with type 1 diabetes: a systematic review and synthesis of qualitative evidence. BMC Pediatr. 2021 Apr 4;21(1):160. doi: 10.1186/s12887-021-02569-4. PMID:33814007 PMCID:PMC8019496
Kohnke S, Buller S, Nuzzaci D, Ridley K, Lam B, Pivonkova H, Bentsen MA, Alonge KM, Zhao C, Tadross J, Holmqvist S, Shimizo T, Hathaway H, Li H, Macklin W, Schwartz MW, Richardson WD, Yeo GSH, Franklin RJM, Karadottir RT, Rowitch DH, Blouet C. Nutritional regulation of oligodendrocyte differentiation regulates perineuronal net remodeling in the median eminence. Cell Rep. 2021 Jul 13;36(2):109362. doi: 10.1016/j.celrep.2021.109362. PMID:34260928 PMCID:PMC8293628
Koprulu M, Zhao Y, Wheeler E, Dong L, Rocha N, Li C, Griffin JD, Patel S, Van de Streek M, Glastonbury CA, Stewart ID, Felix RD, Luan J, Bowker N, Wittemans LBL, Kerrison ND, Cai L, Lucarelli DME, Barroso I, McCarthy MI, Scott RA, Saudek V, Kerrin SS, Wareham NJ, Semple RK, Perry JRB, O’Rahilly S, Lotta LA, Langenberg C, Savage DB. Identification of rare loss of function genetic variation regulating body fat distribution. J Clin Endocrinol Metab. 2021 Dec 7;dgab877. doi: 10.1210/clinem/dgab877. PMID:34875679
Kuhre RE, Modvig IM, Jepsen SL, Kizilkaya HS, Bæch-Laursen C, Smith CA, Reimann F, Gribble FM, Rosenkilde MM, Holst JJ. L-Cell Expression of Melanocortin-4-Receptor Is Marginal in Most of the Small Intestine in Mice and Humans and Direct Stimulation of Small Intestinal Melanocortin-4-Receptors in Mice and Rats Does Not Affect GLP-1 Secretion. Front Endocrinol (Lausanne). 2021 Aug 5;12:690387. doi: 10.3389/fendo.2021.690387. eCollection 2021. PMID:34421821 PMCID:PMC8375664
Lafferty RA, Tanday N, Moffett RC, Reimann F, Gribble FM, Flatt PR, Irwin N. Positive Effects of NPY1 Receptor Activation on Islet Structure Are Driven by Pancreatic Alpha- and Beta-Cell Transdifferentiation in Diabetic Mice. Front Endocrinol (Lausanne). 2021 Feb 25;12:633625. doi: 10.3389/fendo.2021.633625. PMID:33716983 PMCID:PMC7949013
Lam BYH, Williamson A, Finer S, Day FR, Tadross JA, Gonçalves Soares A, Wade K, Sweeney P, Bedenbaugh MN, Porter DT, Melvin A, Ellacott KLJ, Lippert RN, Buller S, Rosmaninho-Salgado J, Dowsett GKC, Ridley KE, Xy Z, Cimino I, Rimmington D, Rainbow K, Duckett K, Holmqvist S, Khan A, Dai , Bochukova EG; Genes & Health Research Team, Trembath RC, Martin HC, Coll AP, Rowditch DH, Wareham NJ, van Heel DA, Timpson N, Simerly RB, Ong KK, Cone RD, Langenberg C, Perry JRB, Yeo GS, O’Rahilly S. MC3R links nutritional state to childhood growth and the timing of puberty. Nature. 2021 Nov 3. doi: 10.1038/s41586-021-04088-9. Epub ahead of print. PMID: 34732894.
Lawton J, Hart R, Kimbell B, Allen JM, Besser REJ, Boughton C, Elleri D, Fuchs J, Ghatak A, Randell T, Thankamony A, Trevelyan N, Hovorka R, Rankin D. Data sharing whilst using a closed-loop system: Qualitative study of adolescents’ and parents’ experiences and views. Diabetes Technol Ther. 2021 Feb 19. doi: 10.1089/dia.2020.0637. PMID:33605790
Leelarathna L, Thabit H, Wilinska ME, Bally L, Mader JK, Pieber TR, Benesch C, Arnolds S, Johnson T, Heinemann L, Hermanns N, Evans ML, Hovorka R. Evaluating Glucose Control With a Novel Composite Continuous Glucose Monitoring Index. J Diabetes Sci Technol. 2020 Mar;14(2):277-283. doi: 10.1177/1932296819838525. PMID: 30931606 PMCID:PMC7196869
Leggat J, Bidault G, Vidal-Puig A. Lipotoxicity: a driver of heart failure with preserved ejection fraction? Clin Sci (Lond). 2021 Oct 15;135(19):2265-2283. doi: 10.1042/CS20210127. PMID: 34643676
Li J, Zhang Y, Ye Y, Li D, Liu Y, Lee E, Zhang M, Dai X, Zhang X, Wang S, Zhang J, Jia W, Zen K, Vidal-Puig A, Jiang X, Zhang CY. Pancreatic β cells control glucose homeostasis via the secretion of exosomal miR-29 family. J Extracell Vesicles. 2021 Jan;10(3):e12055. doi: 10.1002/jev2.12055. PMID:33520119 PMCID:PMC7820156
Liu S, Marcelin G, Blouet C, Jeong JH, Jo YH, Schwartz GJ, Chua S Jr. A gut-brain axis regulating glucose metabolism mediated by bile acids and competitive fibroblast growth factor actions at the hypothalamus. Mol Metab. 2018 Feb;8:37-50. doi: 10.1016/j.molmet.2017.12.003. PMID:29290621 PMCID:PMC5985052
Lockhart SM, O’Rahilly S. Colchicine-an old dog with new tricks. Nat Metab 2021 doi:10.1038/s42255-021-00360-4.PMID: 33846642
Loos RJF, Yeo GSH. The genetics of obesity: from discovery to biology. Nat Rev Genet. 2021 Sep 23:1-14. doi: 10.1038/s41576-021-00414-z. PMID:34556834 PMCID:PMC8459824
Lotta L, Langenberg C, Wareham NJ, Farooqi IS. Reply to Unreliability of genotyping arrays for detecting very rare variants in human genetic studies: Example from a recent study of MC4R. Cell. 2021 Apr 1;184(7):1652-1653. doi: 10.1016/j.cell.2021.03.014. PMID:33798435
Lotta LA, Pietzner M, Stewart ID, Wittemans LBL, Li C, Bonelli R, Raffler J, Biggs EK, Oliver-Williams C, Auyeung VPW, Luan J, Wheeler E, Paige E, Surendran P, Michelotti GA, Scott RA, Burgess S, Zuber V, Sanderson E, Koulman A, Imamura F, Forouhi NG, Khaw KT; MacTel Consortium, Griffin JL, Wood AM, Kastenmüller G, Danesh J, Butterworth AS, Gribble FM, Reimann F, Bahlo M, Fauman E, Wareham NJ, Langenberg C. A cross-platform approach identifies genetic regulators of human metabolism and health. Nat Genet. 2021 Jan;53(1):54-64. doi: 10.1038/s41588-020-00751-5. Epub 2021 Jan 7. PMID: 33414548.
Lu VB, Gribble FM, Reimann F. Nutrient-Induced Cellular Mechanisms of Gut Hormone Secretion. Nutrients. 2021 Mar 9;13(3):883. doi: 10.3390/nu13030883. PMID:33803183 PMCID:PMC8000029
Marcus HJ, Khan DZ, Borg A, Buchfelder M, Cetas JS, Collins JW, Dorward NL, Fleseriu M, Gurnell M, Javadpour M, Jones PS, Koh CH, Layard Horsfall H, Mamelak AN, Mortini P, Muirhead W, Oyesiku NM, Schwartz TH, Sinha S, Stoyanov D, Syro LV, Tsermoulas G, Williams A, Winder MJ, Zada G, Laws ER.Pituitary society expert Delphi consensus: operative workflow in endoscopic transsphenoidal pituitary adenoma resection. Pituitary. 2021 Jul 6:1-15. doi: 10.1007/s11102-021-01162-3. PMID:34231079 PMCID:PMC8259776
Meek CL, Monitoring motherhood: Monitoring and optimizing glycaemia in women with pre-existing diabetes in pregnancy. Ann Clin Biochem. 2021 Aug 3;45632211035815. doi: 10.1177/00045632211035815. PMID:34260324
Meek CL. Swings and roundabouts: Time to rethink our approach to gestational diabetes diagnosis? Diabet Med. 2021 May 9;e14597. doi: 10.1111/dme.14597. PMID:33966291
Meek CL, Corcoy R, Asztalos E, Kusinski LC, López E, Feig DS, Murphy HR; CONCEPTT collaborative group. Which growth standards should be used to identify large- and small-for-gestational age infants of mothers with type 1 diabetes? A pre-specified analysis of the CONCEPTT trial. BMC Pregnancy Childbirth. 2021 Jan 29;21(1):96. doi: 10.1186/s12884-021-03554-6. PMID:3514342 PMCID:PMC7845036
Meek CL, Oram RA, McDonald TJ, Feig DS, Hattersley AT, Murphy HR; CONCEPTT Collaborative Group. Reappearance of C-Peptide During the Third Trimester of Pregnancy in Type 1 Diabetes: Pancreatic Regeneration or Fetal Hyperinsulinism? Diabetes Care. 2021 Aug;44(8):1826-1834. doi: 10.2337/dc21-0028. PMID:34175829
Meek CL, Tundidor D, Feig DS, Yamamoto JM, Scott EM, Ma DD, Halperin JA, Murphy HR, Corcoy R; CONCEPTT Collaborative Group. Novel Biochemical Markers of Glycemia to Predict Pregnancy Outcomes in Women With Type 1 Diabetes. Diabetes Care. 2021 Mar;44(3):681-689. doi: 10.2337/dc20-2360. PMID:33495292 PMCID:PMC8051277
Miedzybrodzka EL, Foreman RE, Lu VB, George AL, Smith CA, Larraufie P, Kay RG, Goldspink DA, Reimann F, Gribble FM. Stimulation of motilin secretion by bile, free fatty acids, and acidification in human duodenal organoids. Mol Metab. 2021 Oct 15;54:101356. doi: 10.1016/j.molmet.2021.101356. PMID:34662713 PMCID:PMC8590067
Mendes de Oliveira E, Keogh JM, Talbot F, Henning E, Ahmed R, Perdikari A, Bounds R, Wasiluk N, Ayinampudi V, Barroso I, Mokrosiński J, Jyothish D, Lim S, Gupta S, Kershaw M, Matei C, Partha P, Randell T, McAculay A, Wilson LC, Cheetham T, Crowne EC, Clayton P, Farooqi IS. Obesity-Associated GNAS Mutations and the Melanocortin Pathway. New England Journal of Medicine, 2021 Oct 21;385(17):1581-1592. doi: 10.1056/NEJMoa2103329. : 34614324
Mennitti LV, Carpenter AAM, Loche E, Pantaleão LC, Fernandez-Twinn DS, Schoonejans JM, Blackmore HL, Ashmore TJ, Pisani LP, Tadross JA, Hargreaves I, Ozanne SE. Effects of maternal diet-induced obesity on metabolic disorders and age-associated miRNA expression in the liver of male mouse offspring. Int J Obes (Lond). 2021 Oct 18. doi: 10.1038/s41366-021-00985-1. PMID:34663892
Menzies-Gow A, Gurnell M, Heaney LG, Corren J, Bel EH, Maspero J, Harrison T, Jackson DJ, Price D, Lugogo N, Kreindler J, Burden A, de Giorgio-Miller A, Padilla K, Martin UJ, Garcia Gil E. Oral corticosteroid elimination via a personalised reduction algorithm in adults with severe, eosinophilic asthma treated with benralizumab (PONENTE): a multicentre, open-label, single-arm study. Lancet Respir Med. 2021 Oct 4;S2213-2600(21)00352-0. doi: 10.1016/S2213-2600(21)00352-0. PMID:34619104
Menzies-Gow A, Kreindler J, Katial R, Gurnell M. Adrenal insufficiency in patients taking benralizumab as corticosteroid sparing therapy – Authors’ reply. Lancet Respir Med. 2021 Nov 8;S2213-2600(21)00489-6. doi: 10.1016/S2213-2600(21)00489-6. PMID:34762847
Moore SE, Doel AM, Ong KK, Dunger DB, Affara NA, Prentice AM, Bernstein RM; HERO-G Working Group. Identification of nutritionally modifiable hormonal and epigenetic drivers of positive and negative growth deviance in rural African fetuses and infants: Project protocol and cohort description. Gates Open Res. 2020 Feb 24;4:25. doi: 10.12688/gatesopenres.13101.1. PMID:33693312 PMCID:PMC7921526
Moran C, McEniery CM, Schoenmakers N, Mitchell C, Sleigh A, Watson L, Lyons G, Burling K, Barker P, Chatterjee K. Dyslipidemia, insulin resistance, ectopic lipid accumulation and vascular function in Resistance to Thyroid Hormone β. J Clin Endocrinol Metab. 2021 Feb 1:dgab002. doi: 10.1210/clinem/dgab002. PMID:33524107
Mulderrig L, Garaycoechea JI, Tuong ZK, Millington CL, Dingler FA, Ferdinand JR, Gaul L, Tadross JA, Arends MJ, O’Rahilly S, Crossan GP, Clatworthy MR, Patel KJ. Aldehyde-driven transcriptional stress triggers an anorexic DNA damage response. Nature. 2021 Dec;600(7887):158-163. doi: 10.1038/s41586-021-04133-7. PMID:34819667
Muzurović E, van der Lely AJ, Gurnell M. AST to ALT Ratio and Peripheral Arterial Disease in a Hypertensive Population-Is There a Link? Angiology. 2021 Mar 24:33197211004387. doi: 10.1177/00033197211004387. PMID:33759592
Napso T, Zhao X, Lligoña MI, Sandovici I, Kay RG, George AL, Gribble FM, Reimann F, Meek CL, Hamilton RS, Sferruzzi-Perri AN. Placental secretome characterization identifies candidates for pregnancy complications. Commun Biol. 2021 Jun 8;4(1):701. doi: 10.1038/s42003-021-02214-x. PMID:34103657 PMCID:PMC8187406
Naumenko DJ, Dykes J, O’Connor GK, Stanley Z, Affara N, Doel AM, Drammeh S, Dunger DB, Faal A, Ong KK, Sosseh F, Prentice AM, Moore SE, Bernstein RM. A Novel method for the identification and quantification of weight faltering. Am J Phys Anthropol. 2021 Jan 1. doi: 10.1002/ajpa.24217. PMID:33386624
Nixon R, Ip THR, Jenkins B, Yip PK, Clarke P, Ponnusamy V, Michael-Titus AT, Koulman A, Shah DK. Lipid Profiles from Dried Blood Spots Reveal Lipidomic Signatures of Newborns Undergoing Mild Therapeutic Hypothermia after Hypoxic-Ischemic Encephalopathy. Nutrients. 2021 Nov 28;13(12):4301. doi: 10.3390/nu13124301. PMID:34959853 PMCID:PMC8703828
Nizari S, Basalay M, Chapman P, Korte N, Korsak A, Christie IN, Theparambil SM, Davidson SM, Reimann F, Trapp S, Yellon DM, Gourine AV. Glucagon-like peptide-1 (GLP-1) receptor activation dilates cerebral arterioles, increases cerebral blood flow, and mediates remote (pre)conditioning neuroprotection against ischaemic stroke. Basic Res Cardiol. 2021 May 3;116(1):32. doi: 10.1007/s00395-021-00873-9. PMID:33942194 PMCID:PMC8093159
Nyimanu D, Kay RG, Kuc RE, Brown AJH, Gribble FM, Maguire JJ, Davenport AP. In vitro metabolism of synthetic Elabela/Toddler (ELA-32) peptide in human plasma and kidney homogenates analyzed with mass spectrometry and validation of endogenous peptide quantification in tissues by ELISA. Peptides. 2021 Aug 26;145:170642. doi: 10.1016/j.peptides.2021.170642. PMID:34455010
Olga L, van Diepen JA, Bobeldijk-Pastorova I, Gross G, Prentice PM, Snowden SG, Furse S, Kooistra T, Hughes IA, Schoemaker MH, van Tol EAF, van Duyvenvoorde W, Wielinga PY, Ong KK, Dunger DB, Kleemann R, Koulman A. Lipid ratios representing SCD1, FADS1, and FADS2 activities as candidate biomarkers of early growth and adiposity. EBioMedicine. 2021 Jan 6;63:103198. doi: 10.1016/j.ebiom.2020.103198. Epub ahead of print. PMID: 33421943; PMCID: PMC7806876.
Olga L, van Beijsterveldt IALP, Hughes IA, Dunger DB, Ong KK, Hokken-Koelega ACS, De Lucia Rolfe E. Anthropometry-based prediction of body composition in early infancy compared to air-displacement plethysmography. Pediatr Obes. 2021 Jun 10:e12818. doi: 10.1111/ijpo.12818. PMID:34114363
O’Rahilly S. The islet’s bridesmaid becomes the bride: Proglucagon-derived peptides deliver transformative therapies. Cell 2021:S0092-8674(21)00304-4. doi:10.1016/j.cell.2021.03.019. PMID:33831374
O’Rahilly S. The islet’s bridesmaid becomes the bride: Proglucagon-derived peptides deliver transformative therapies. Cell. 2021 Jul 22;184(15):4105. doi: 10.1016/j.cell.2021.07.008. PMID:34297931
O’Rahilly S. “Treasure Your Exceptions”-Studying Human Extreme Phenotypes to Illuminate Metabolic Health and Disease: The 2019 Banting Medal for Scientific Achievement Lecture. Diabetes. 2021 Jan;70(1):29-38. doi: 10.2337/dbi19-0037. PMID:33355307 PMCID:PMC7881844
Pegram C, Raffan E, White E, Ashworth AH, Brodbelt DC, Church DB, O’Neill DG. Frequency, breed predisposition and demographic risk factors for overweight status in dogs in the UK. J Small Anim Pract. 2021 Mar 23. doi: 10.1111/jsap.13325. PMID:
Pérez-Sánchez C, Barbarroja N, Pantaleão LC, López-Sánchez LM, Ozanne SE, Jurado-Gámez B, Aranda E, Lopez-Pedrera C, Rodríguez-Ariza A. Clinical Utility of microRNAs in Exhaled Breath Condensate as Biomarkers for Lung Cancer. Pers Med. 2021 Feb 9;11(2):111. doi: 10.3390/jpm11020111. PMID:33572343
Petkevicius K, Bidault G, Virtue S, Jenkins B, van Dierendonck XAMH, Dugourd A, Saez-Rodriguez J, Stienstra R, Koulman A, Vidal-Puig A. Norepinephrine promotes triglyceride storage in macrophages via beta2-adrenergic receptor activation. FASEB J. 2021 Feb;35(2):e21266. doi: 10.1096/fj.202001101R. PMID: 33484195.
Petkevicius K, Bidault G, Virtue S, Newland SA, Dale M, Dugourd A, Saez-Rodriguez J, Mallat Z, Vidal-Puig A. Macrophage beta2-adrenergic receptor is dispensable for the adipose tissue inflammation and function. Molecular Metabolism. 2021 Mar 25;48:101220. doi: 10.1016/j.molmet.2021.101220. PMID: 33774223
Petry CJ, Burling KA, Barker P, Hughes IA, Ong KK, Dunger DB. Pregnancy Serum DLK1 Concentrations are associated with Indices of Insulin Resistance and Secretion. J Clin Endo Metab. 2021 Feb 26;dgab123. doi: 10.1210/clinem/dgab123. PMID:33640968
Petry CJ, Ong KK, Hughes IA, Dunger DB. Folic acid supplementation during pregnancy and associations with offspring size at birth and adiposity: a cohort study. BMC Res Notes. 2021 Apr 30;14(1):160. doi: 10.1186/s13104-021-05575-y. PMID:33931129 PMCID:PMC8086326
Pietzner M, Wheeler E, Carrasco-Zanini J, Cortes A, Koprulu M, Wörheide MA, Oerton E, Cook J, Stewart ID, Kerrison ND, Luan J, Raffler J, Arnold M, Arlt W, O’Rahilly S, Kastenmüller G, Gamazon ER, Hingorani AD, Scott RA, Wareham NJ, Langenberg C. Mapping the proteo-genomic convergence of human diseases. Science. 2021 Nov 12;374(6569):eabj1541. doi: 10.1126/science.abj1541. PMID:34648354
Quarta C, Claret M, Zeltser LM, Williams KW, Yeo GSH, Tschöp MH, Diano S, Brüning JC, Cota D. POMC neuronal heterogeneity in energy balance and beyond: an integrated view. Nat Metab. 2021 Feb 25. doi: 10.1038/s42255-021-00345-3. PMID:33633406
Quilter CR, Harvey KM, Bauer J, Skinner BM, Gomez M, Shrivastava M, Doel AM, Drammeh S, Dunger DB, Moore SE, Ong KK, Prentice AM, Bernstein RM, Sargent CA, Affara NA. Identification of methylation changes associated with positive and negative growth deviance in Gambian infants using a targeted methyl sequencing approach of genomic DNA. FASEB Bioadv. 2021 Feb 5;3(4):205-230. doi: 10.1096/fba.2020-00101. PMID:33842847. PMCID:PMC8019263
Rankin D, Kimbell B, Allen JM, Besser REJ, Boughton CK, Campbell F, Elleri D, Fuchs J, Ghatak A, Randell T, Thankamony A, Trevelyan N, Wilinska ME, Hovorka R, Lawton J. Adolescents’ Experiences of Using a Smartphone Application Hosting a Closed-loop Algorithm to Manage Type 1 Diabetes in Everyday Life: Qualitative Study. J Diabetes Sci Technol. 2021 Jul 14:1932296821994201. doi: 10.1177/1932296821994201. PMID:34261348
Rankin D, Kimbell B, Hovorka R, Lawton J. Adolescents’ and their parents’ experiences of using a closed-loop system to manage type 1 diabetes in everyday life: qualitative study. Chronic Illn. 2021 Jan 20:1742395320985924. doi: 10.1177/1742395320985924. PMID:33472409
Rao S, Yang X, Ohshiro K, Zaidi S, Wang Z, Shetty K, Xiang X, Hassan MI, Mohammad T, Latham PS, Nguyen BN, Wong L, Yu H, Al-Abed Y, Mishra B, Vacca M, Guenigault G, Allison MED, Vidal-Puig A, Benhammou JN, Alvarez M, Pajukanta P, Pisegna JR, Mishra L. β2-spectrin (SPTBN1) as a therapeutic target for diet-induced liver disease and preventing cancer development. Sci Transl Med. 2021 Dec 15;13(624):eabk2267. doi: 10.1126/scitranslmed.abk2267. PMID:34910547
Robertson TM, Brown JE, Fielding BA, Hovorka R, Robertson MD. Resistant Starch Production and Glucose Release from Pre-Prepared Chilled Food: The SPUD Project. Nutr Bull. 2021 Mar;46(1):52-59. doi: 10.1111/nbu.12476. PMID:33776583 PMCID:PMC7984060
Rodriguez-Cuenca S, Lelliot CJ, Campbell M, Peddinti G, Martinez-Uña M, Ingvorsen C, Dias AR, Relat J, Mora S, Hyötyläinen T, Zorzano A, Orešič M, Bjursell M, Bohlooly-Y M, Lindén D, Vidal-Puig A. Allostatic hypermetabolic response in PGC1α/β heterozygote mouse despite mitochondrial defects. FASEB J. 2021 Sep;35(9):e21752. doi: 10.1096/fj.202100262RR. PMID:34369602
Rodriguez-Cuenca S, Vidal-Puig A. Insulin and the last gasp of failing adipocytes. Nat Metab. 2021 Nov;3(11):1443-1444. doi: 10.1038/s42255-021-00492-7. PMID:34732886
Romero-Picó A, Sanchez-Rebordelo E, Imbernon M, González-Touceda D, Folgueira C, Senra A, Fernø J, Blouet C, Cabrera R, van Gestel M, Adan RA, López M, Maldonado R, Nogueiras R, Diéguez C. Melanin-Concentrating Hormone acts through hypothalamic kappa opioid system and p70S6K to stimulate acute food intake. Neuropharmacology. 2018 Mar 1;130:62-70. doi: 10.1016/j.neuropharm.2017.11.040. PMID:29191753
Rowe ER, Mimmack ML, Barbosa AD, Haider A, Isaac I, Ouberai MM, Thiam AR, Patel S, Saudek V, Siniossoglou S, Savage DB. Correction: Conserved amphipathic helices mediate lipid droplet targeting of perilipins 1-3. J Biol Chem. 2021 Dec 20;298(1):101490. doi: 10.1016/j.jbc.2021.101490. PMID:34942404 PMCID:PMC8695350
Ruth KS, Day FR, Hussain J, Martínez-Marchal A, Aiken CE, Azad A, Thompson DJ, Knoblochova L, Abe H, Tarry-Adkins JL, Gonzalez JM, Fontanillas P, Claringbould A, Bakker OB, Sulem P, Walters RG, Terao C, Turon S, Horikoshi M, Lin K, Onland-Moret NC, Sankar A, Hertz EPT, Timshel PN, Shukla V, Borup R, Olsen KW, Aguilera P, Ferrer-Roda M, Huang Y, Stankovic S, Timmers PRHJ, Ahearn TU, Alizadeh BZ, Naderi E, Andrulis IL, Arnold AM, Aronson KJ, Augustinsson A, Bandinelli S, Barbieri CM, Beaumont RN, Becher H, Beckmann MW, Benonisdottir S, Bergmann S, Bochud M, Boerwinkle E, Bojesen SE, Bolla MK, Boomsma DI, Bowker N, Brody JA, Broer L, Buring JE, Campbell A, Campbell H, Castelao JE, Catamo E, Chanock SJ, Chenevix-Trench G, Ciullo M, Corre T, Couch FJ, Cox A, Crisponi L, Cross SS, Cucca F, Czene K, Smith GD, de Geus EJCN, de Mutsert R, De Vivo I, Demerath EW, Dennis J, Dunning AM, Dwek M, Eriksson M, Esko T, Fasching PA, Faul JD, Ferrucci L, Franceschini N, Frayling TM, Gago-Dominguez M, Mezzavilla M, García-Closas M, Gieger C, Giles GG, Grallert H, Gudbjartsson DF, Gudnason V, Guénel P, Haiman CA, Håkansson N, Hall P, Hayward C, He C, He W, Heiss G, Høffding MK, Hopper JL, Hottenga JJ, Hu F, Hunter D, Ikram MA, Jackson RD, Joaquim MDR, John EM, Joshi PK, Karasik D, Kardia SLR, Kartsonaki C, Karlsson R, Kitahara CM, Kolcic I, Kooperberg C, Kraft P, Kurian AW, Kutalik Z, La Bianca M, LaChance G, Langenberg C, Launer LJ, Laven JSE, Lawlor DA, Le Marchand L, Li J, Lindblom A, Lindstrom S, Lindstrom T, Linet M, Liu Y, Liu S, Luan J, Mägi R, Magnusson PKE, Mangino M, Mannermaa A, Marco B, Marten J, Martin NG, Mbarek H, McKnight B, Medland SE, Meisinger C, Meitinger T, Menni C, Metspalu A, Milani L, Milne RL, Montgomery GW, Mook-Kanamori DO, Mulas A, Mulligan AM, Murray A, Nalls MA, Newman A, Noordam R, Nutile T, Nyholt DR, Olshan AF, Olsson H, Painter JN, Patel AV, Pedersen NL, Perjakova N, Peters A, Peters U, Pharoah PDP, Polasek O, Porcu E, Psaty BM, Rahman I, Rennert G, Rennert HS, Ridker PM, Ring SM, Robino A, Rose LM, Rosendaal FR, Rossouw J, Rudan I, Rueedi R, Ruggiero D, Sala CF, Saloustros E, Sandler DP, Sanna S, Sawyer EJ, Sarnowski C, Schlessinger D, Schmidt MK, Schoemaker MJ, Schraut KE, Scott C, Shekari S, Shrikhande A, Smith AV, Smith BH, Smith JA, Sorice R, Southey MC, Spector TD, Spinelli JJ, Stampfer M, Stöckl D, van Meurs JBJ, Strauch K, Styrkarsdottir U, Swerdlow AJ, Tanaka T, Teras LR, Teumer A, Þorsteinsdottir U, Timpson NJ, Toniolo D, Traglia M, Troester MA, Truong T, Tyrrell J, Uitterlinden AG, Ulivi S, Vachon CM, Vitart V, Völker U, Vollenweider P, Völzke H, Wang Q, Wareham NJ, Weinberg CR, Weir DR, Wilcox AN, van Dijk KW, Willemsen G, Wilson JF, Wolffenbuttel BHR, Wolk A, Wood AR, Zhao W, Zygmunt M; Biobank-based Integrative Omics Study (BIOS) Consortium; eQTLGen Consortium; Biobank Japan Project; China Kadoorie Biobank Collaborative Group; kConFab Investigators; LifeLines Cohort Study; InterAct consortium; 23andMe Research Team, Chen Z, Li L, Franke L, Burgess S, Deelen P, Pers TH, Grøndahl ML, Andersen CY, Pujol A, Lopez-Contreras AJ, Daniel JA, Stefansson K, Chang-Claude J, van der Schouw YT, Lunetta KL, Chasman DI, Easton DF, Visser JA, Ozanne SE, Namekawa SH, Solc P, Murabito JM, Ong KK, Hoffmann ER, Murray A, Roig I, Perry JRB. Genetic insights into biological mechanisms governing human ovarian ageing. Nature. 2021 Aug;596(7872):393-397. doi: 10.1038/s41586-021-03779-7. PMID:34349265
Sam AH, Reid MD, Thakerar V, Gurnell M, Westacott R, Yeates P, Reed MWR, Brown CA. The influence of candidates’ physical attributes on assessors’ ratings in clinical practice. Med Teach. 2021 Feb 11:1-6. doi: 10.1080/0142159X.2021.1877268. PMID:33569973
Sam AH, Wilson R, Westacott R, Gurnell M, Melville C, Brown CA. Thinking differently – Students’ cognitive processes when answering two different formats of written question. Med Teach. 2021 Jun 14:1-8. doi: 10.1080/0142159X.2021.1935831. PMID:34126840
Samms RJ, Sloop KW, Gribble FM, Reimann F, Adriaenssens AE. GIPR Function in the Central Nervous System: Implications and Novel Perspectives for GIP-Based Therapies in Treating Metabolic Disorders. Diabetes. 2021 Jun 27:dbi210002. doi: 10.2337/dbi21-0002. PMID:34176786
Sanchez-Delgado G, Martinez-Tellez B, Acosta FM, Virtue S, Vidal-Puig A, Gil A, Llamas-Elvira JM, Ruiz JR. Brown Adipose Tissue Volume and Fat Content are Positively Associated with Whole-Body Adiposity in Young Men, Not in Women. Diabetes. 2021 Apr 15:db210011. doi: 10.2337/db21-0011. PMID:33858825
Sandovici I, Georgopoulou A, Pérez-García V, Hufnagel A, López-Tello J, Lam BYH, Schiefer SN, Gaudreau C, Santos F, Hoelle K, Yeo GSH, Burling K, Reiterer M, Fowden AL, Burton GJ, Branco CM, Sferruzzi-Perri AN, Constância M. The imprinted Igf2-Igf2r axis is critical for matching placental microvasculature expansion to fetal growth. Dev Cell. 2022 Jan 10;57(1):63-79.e8. doi: 10.1016/j.devcel.2021.12.005. PMID:34963058 PMCID:PMC8751640
Sandovici I, Hammerle CM, Virtue S, Vivas-Garcia Y, Izquierdo-Lahuerta A, Ozanne SE, Vidal-Puig A, Medina-Gómez G & Constância M. Autocrine IGF2 programmes β-cell plasticity under conditions of increased metabolic demand. Scientific Reports. 2021 Apr 8;11(1):7717. doi: 10.1038/s41598-021-87292-x. PMID:33833312 PMCID:PMC8032793
Saucisse N, Mazier W, Simon V, Binder E, Catania C, Bellocchio L, Romanov RA, Léon S, Matias I, Zizzari P, Quarta C, Cannich A, Meece K, Gonzales D, Clark S, Becker JM, Yeo GSH, Fioramonti X, Merkle FT, Wardlaw SL, Harkany T, Massa F, Marsicano G, Cota D. Functional heterogeneity of POMC neurons relies on mTORC1 signaling. Cell Rep. 2021 Oct 12;37(2):109800. doi: 10.1016/j.celrep.2021.109800. PMID:34644574
Schoonejans JM, Blackmore HL, Ashmore TJ, Aiken CE, Fernandez-Twinn DS, Ozanne SE. Maternal Metformin Intervention during Obese Glucose-Intolerant Pregnancy Affects Adiposity in Young Adult Mouse Offspring in a Sex-Specific Manner. Int J Mol Sci. 2021 Jul 28;22(15):8104. doi: 10.3390/ijms22158104. PMID:34360870 PMCID:PMC8347264
Schoonejans JM, Ozanne SE. Developmental programming by maternal obesity: Lessons from animal models. Diabet Med. 2021 Sep 23;e14694. doi: 10.1111/dme.14694. PMID:34553414
Seelig E, Henning E, Keogh JM, Gillett D, Shin E, Buscombe J, van der Klaauw AA, Farooqi IS. Obesity due to melanocortin 4 receptor (MC4R) deficiency is associated with delayed gastric emptying. Clin Endocrinol (Oxf). 2021 Oct 25. doi: 10.1111/cen.14615. PMID:34694010
Senanayake R, Gillett D, MacFarlane J, Van de Meulen M, Powlson A, Koulouri O, Casey R, Bashari W, Gurnell M. New types of localization methods for adrenocorticotropic hormone-dependent Cushing’s syndrome. Best Pract Res Clin Endocrinol Metab. 2021 Jan;35(1):101513. PMID:34045044
Spiroski AM, Niu Y, Nicholas LM, Austin-Williams S, Camm EJ, Sutherland MR, Ashmore TJ, Skeffington KL, Logan A, Ozanne SE, Murphy MP, Giussani DA. Mitochondria antioxidant protection against cardiovascular dysfunction programmed by early-onset gestational hypoxia. FASEB J. 2021 May;35(5):e21446. doi: 10.1096/fj.202002705R. PMID:33788974
Stern E, Schoenmakers N, Nicholas AK, Kassif E, Hamiel OP, Yeshayahu Y. A Novel mutation in the Thyroglobulin Gene resulting in Neonatal Goiter and Congenital Hypothyroidism in an Eritrean infant. J Clin Res Pediatr Endocrinol. 2021 Apr 9. doi: 10.4274/jcrpe.galenos.2021.2020.0278. PMID:33832185
Tarry-Adkins JL, Grant ID, Ozanne SE, Reynolds RM, Aiken CE. Efficacy and Side Effect Profile of Different Formulations of Metformin: A Systematic Review and Meta-Analysis. Diabetes Ther. 2021 Jun 2. doi: 10.1007/s13300-021-01058-2. PMID:34075573
Tarry-Adkins JL, Ozanne SE, Aiken CE. Impact of metformin treatment during pregnancy on maternal outcomes: a systematic review/meta-analysis. Sci Rep. 2021 Apr 29;11(1):9240. doi: 10.1038/s41598-021-88650-5. PMID:33927270 PMCID:PMC8085032
Tilson SG, Morell CM, Lenaerts AS, Park SB, Hu Z, Jenkins B, Koulman A, Liang TJ, Vallier L. Modelling PNPLA3-Associated Non-Alcoholic Fatty Liver Disease Using Human Induced Pluripotent Stem Cells. Hepatology. 2021 Jul 20. doi: 10.1002/hep.32063. PMID:34288010
Torok ME, Underwood BR, Toshner M, Waddington C, Sidhom E, Sharrocks K, Bousfield R, Summers C, Saunders C, McIntyre Z, Morris H, Piper J, Calderon G, Dennis S, Assari T, Marguerie de Rotrou A, Shaw A, Bradley J, O’Brien J, Rintoul RC, Smith I, Bullmore E, Chatterjee K and on behalf of the Cambridge COVID vaccine trial team. Challenges and opportunities for conducting a vaccine trial during the COVID-19 pandemic in the United Kingdom. Clinical Trials 2021. https://doi.org/10.1177/17407745211024764. PMID:34154428
Tritos NA, Fazeli PK, McCormack A, Mallea-Gil SM, Pineyro MM, Christ-Crain M, Frara S, Labadzhyan A, Ioachimescu AG, Shimon I, Takahashi Y, Gurnell M, Fleseriu M; “Pituitary Society Delphi Collaborative Group”. Pituitary Society Delphi Survey: An international perspective on endocrine management of patients undergoing transsphenoidal surgery for pituitary adenomas. Pituitary. 2021 Jul 20:1-10. doi: 10.1007/s11102-021-01170-3. PMID:34283370 PMCID:PMC8294287
Tundidor D, Meek CL, Yamamoto J, Martínez-Bru C, Gich I, Feig DS, Murphy HR, Corcoy R; CONCEPTT Collaborative Group. Continuous Glucose Monitoring Time-in-Range and HbA 1c Targets in Pregnant Women with Type 1 Diabetes. Diabetes Technol Ther. 2021 May 25. doi: 10.1089/dia.2021.0073. PMID:33945304
van Beijsterveldt IALP, Snowden SG, Myers PN, de Fluiter KS, van de Heijning B, Brix S, Ong KK, Dunger DB, Hokken-Koelega ACS, Koulman A. Metabolomics in early life and the association with body composition at age 2 years. Pediatr Obes. 2021 Oct 13;e12859. doi: 10.1111/ijpo.12859. PMID:34644810
van Geest FS, Groeneweg S, van den Akker ELT, Bacos I, Barca D, van den Berg SAA, Bertini E, Brunner D, Brunetti-Pierri N, Cappa M, Cappuccio G, Chatterjee K, Chesover AD, Christian P, Coutant R, Craiu D, Crock P, Dewey C, Dica A, Dimitri P, Dubey R, Enderli A, Fairchild J, Gallichan J, Garibaldi LR, George B, Hackenberg A, Heinrich B, Huynh T, Kłosowska A, Lawson-Yuen A, Linder-Lucht M, Lyons G, Lora FM, Moran C, Müller KE, Paone L, Paul PG, Polak M, Porta F, Reinauer C, de Rijke YB, Seckold R, Menevşe TS, Simm P, Simon A, Spada M, Stoupa A, Szeifert L, Tonduti D, van Toor H, Turan S, Vanderniet J, de Waart M, van der Wal R, van der Walt A, van Wermeskerken AM, Wierzba J, Zibordi F, Zung A, Peeters RP, Visser WE. Long-term efficacy of T3 analogue Triac in children and adults with MCT8 deficiency: a real-life retrospective cohort study. J Clin Endocrinol Metab. 2021 Oct 22:dgab750. doi: 10.1210/clinem/dgab750. PMID:34679181
Vickneson K, Blackburn J, Gallagher JR, Evans ML, de Galan BE, Pedersen-Bjergaard U, Thorens B, McNeilly AD, McCrimmon RJ. Cold-induced dishabituation in rodents exposed to recurrent hypoglycaemia. Diabetologia. 2021 Mar 17. doi: 10.1007/s00125-021-05425-3. PMID:33730186
Virtue S, Lelliott CJ, Vidal-Puig A.What is the most appropriate covariate in ANCOVA when analysing metabolic rate? Nat Metab. 2021 Dec;3(12):1585. doi: 10.1038/s42255-021-00505-5. PMID:34903886
Virtue S, Vidal-Puig A. GTTs and ITTs in mice: simple tests, complex answers. Nat Metab. 2021 Jun 11. doi: 10.1038/s42255-021-00414-7. PMID:34117483
Wade KH, Lam BYH, Melvin A, Pan W, Corbin LJ, Hughes DA, Rainbow K, Chen JH, Duckett D, Liu X, Mokrosinski J, Morseburg A, Neaves S, Williamson A, Zhang C, Farooqi S, Yeo GSH, Timpson NJ, O’Rahilly S. Loss of function mutations in the melanocortin 4 receptor in a UK birth cohort. Nat Med. 2021 May 27. doi: 10.1038/s41591-021-01349-y. PMID:34045736
Ward DL, Schroeder L, Pomeroy E, Roy JE, Buck LT, Stock JT, Martin-Gronert M, Ozanne SE, Silcox MT, Viola TB. Early life malnutrition and fluctuating asymmetry in the rat bony labyrinth. Anat Rec (Hoboken). 2021 Feb 15. doi: 10.1002/ar.24601. PMID:33586866
Ware J, Hovorka R. Recent advances in closed-loop insulin delivery. Metabolism. 2022 Feb;127:154953. doi: 10.1016/j.metabol.2021.154953. PMID:34890648
Westwater ML, Mancini F, Gorka AX, Shapleske J, Serfontein J, Grillon C, Ernst M, Ziauddeen H, Fletcher PC. Prefrontal responses during proactive and reactive inhibition are differentially impacted by stress in anorexia and bulimia nervosa. J Neurosci. 2021 Apr 12:JN-RM-2853-20. doi: 10.1523/JNEUROSCI.2853-20.2021. PMID:33846229
Wever MCM, van Meer F, Charbonnier L, Crabtree DR, Buosi W, Giannopoulou A, Androutsos O, Johnstone AM, Manios Y, Meek CL, Holst JJ, Smeets PAM; Full4Health consortium. Associations between ghrelin and leptin and neural food cue reactivity in a fasted and sated state. Neuroimage. 2021 Oct 15;240:118374. doi: 10.1016/j.neuroimage.2021.118374. PMID:34245869
Woodward OR, Gribble FM, Reimann F, Lewis JE. Gut peptide regulation of food intake – evidence for the modulation of hedonic feeding. J Physiol. 2021 Jun 21. doi: 10.1113/JP280581. PMID:34152020
Wylie TA, Shah C, Burgess L, Robertson E, Dupont D, Swindell R, Hovorka R, Murphy HR, Heller SR. Optimising the use of technology to support people with diabetes: research recommendations from Diabetes UK’s 2019 diabetes and technology workshop. Diabet Med. 2021 Jul 16:e14647. doi: 10.1111/dme.14647. PMID:34270822
Yang M, Darwish T, Larraufie P, Rimmington D, Cimino I, Goldspink DA, Jenkins B, Koulman A, Brighton CA, Ma M, Lam BYH, Coll AP, O’Rahilly S, Reimann F, Gribble FM. Inhibition of mitochondrial function by metformin increases glucose uptake, glycolysis and GDF-15 release from intestinal cells. Sci Rep. 2021 Jan 28;11(1):2529. doi: 10.1038/s41598-021-81349-7. PMID:33510216 PMCID:PMC7843649
Yang M, Reimann F, Gribble FM. Chemosensing in enteroendocrine cells: mechanisms and therapeutic opportunities. Curr Opin Endocrinol Diabetes Obes. 2021 Apr 1;28(2):222-231. doi: 10.1097/MED.0000000000000614. PMID:33449572
Yeo GSH, Moro Chao DH, Siegert AM, Koerperich ZM, Ericson MD, Simonds SE, Larson CM, Luquet S, Clarke I, Sharma S, Clément K, Cowley MA, Haskell-Luevano C, Van Der Ploeg L, Adan RAH. The melanocortin pathway and energy homeostasis: From discovery to obesity therapy. Mol Metab. 2021 Mar 5:101206. doi: 10.1016/j.molmet.2021.101206. PMID:33684608
Yeo GSH, O’Rahilly S. Finding genes that control body weight. Science. 2021 Jul 2;373(6550):30-31. doi: 10.1126/science.abh3556. PMID:34210869
Zhou J, Azizan EAB, Cabrera CP, Fernandes-Rosa FL, Boulkroun S, Argentesi G, Cottrell E, Amar L, Wu X, O’Toole S, Goodchild E, Marker A, Senanayake R, Garg S, Åkerström T, Backman S, Jordan S, Polubothu S, Berney DM, Gluck A, Lines KE, Thakker RV, Tuthill A, Joyce C, Kaski JP, Karet Frankl FE, Metherell LA, Teo AED, Gurnell M, Parvanta L, Drake WM, Wozniak E, Klinzing D, Kuan JL, Tiang Z, Gomez Sanchez CE, Hellman P, Foo RSY, Mein CA, Kinsler VA, Björklund P, Storr HL, Zennaro MC, Brown MJ. Somatic mutations of GNA11 and GNAQ in CTNNB1-mutant aldosterone-producing adenomas presenting in puberty, pregnancy or menopause. Nat Genet. 2021 Sep;53(9):1360-1372. doi: 10.1038/s41588-021-00906-y. PMID:34385710

2020

Alligier M, Barrès R, Blaak EE, Boirie Y, Bouwman J, Brunault P, Campbell K, Clément K, Farooqi IS, Farpour-Lambert NJ, Frühbeck G, Goossens GH, Hager J, Halford JCG, Hauner H, Jacobi D, Julia C, Langin D, Natali A, Neovius M, Oppert JM, Pagotto U, Palmeira AL, Roche H, Rydén M, Scheen AJ, Simon C, Sorensen TIA,Tappy L, Yki-Järvinen H, Ziegler O, Laville M. OBEDIS Core Variables roject: European Expert Guidelines on a Minimal Core Set of Variables to Include in Randomized, Controlled Clinical Trials of Obesity Interventions. Obes Facts. 2020 Jan 13:1-28. Epub ahead of print. PubMed PMID: 31945762. PMCID: PMC7098277.
Anstee QM, Darlay R, Cockell S, Meroni M, Govaere O, Tiniakos D, Burt AD, Bedossa P, Palmer J, Liu YL, Aithal GP, Allison M, Yki-Järvinen H, Vacca M, Dufour JF, Invernizzi P, Prati D, Ekstedt M, Kechagias S, Francque S, Petta S, Bugianesi E, Clement K, Ratziu V, Schattenberg JM, Valenti L, Day CP, Cordell HJ, Daly AK; EPoS Consortium Investigators. Genome-wide Association Study of Non-Alcoholic Fatty Liver and Steatohepatitis in a Histologically-Characterised Cohort. Journal of Hepatology. 2020 Apr 13:S0168-8278(20)30213-0. PMID: 32298765.
Araiz C, Yan A, Bettedi L, Samuelson I, Virtue S, McGavigan AK, Dani C, Vidal-Puig A, Foukas LC. Publisher Correction: Enhanced β-Adrenergic Signalling Underlies an Age-Dependent Beneficial Metabolic Effect of PI3K p110α Inactivation in Adipose Tissue. Nat Commun. 2020 Feb 21;11(1):1078. PMID: 32081871.
Ast J, Arvaniti A, Fine NHF, Nasteska D, Ashford FB, Stamataki Z, Koszegi Z, Bacon A, Jones BJ, Lucey MA, Sasaki S, Brierley DI, Hastoy B, Tomas A, D’Agostino G, Reimann F, Lynn FC, Reissaus CA, Linnemann AK, D’Este E, Calebiro D, Trapp S, Johnsson K, Podewin T, Broichha- gen J, Hodson DJ. Author Correction: Super-resolution microscopy compatible fluorescent probes reveal endogenous glucagon-like peptide-1 receptor distribution and dynamics. Nat Commun. 2020 Oct 9;11(1):5160. PMID: 33037231.
Azzu V, Vacca M, Virtue S, Allison M, Vidal-Puig A. Adipose tissue-liver cross talk in the control of whole-body metabolism: implications in non-alcoholic fatty liver disease. Gastroenterology. 2020 Feb 12. pii: S0016-5085(20)30224-9. Epub ahead of print. PMID: 32061598.
Baig S, Shabeer M, Parvaresh Rizi E, Agarwal M, Lee MH, Ooi DSQ, Chia C, Aung N, Ng G, Teo Y, Chhay V, Magkos F, Vidal-Puig A, Seet RCS, Toh SA. Heredity of type 2 diabetes confers increased susceptibility to oxidative stress and inflammation. BMJ Open Diabetes Res Care. 2020 Jan;8(1). PMID: 32049633. PMCID: PMC7039582.
Banholzer N, Herzig D, Piazza C, Álvarez-Martínez M, Nakas CT, Kosinski C, Feuerriegel S, Hovorka R, Bally L. Effect of nutrition on postprandial glucose control in hospitalized patients with type 2 diabetes receiving fully automated closed-loop insulin therapy. Diabetes Obes Metab. 2020 Sep 4. PMID: 32885596.
Bashari WA, Senanayake R, Koulouri O, Gillett D, MacFarlane J, Powlson AS, FernandezPombo A, Bano G, Martin AJ, Scoffings D, Cheow H, Mendichovszky I, Tysome J, Donnelly N, Santarius T, Kolias A, Mannion R, Gurnell M. PET-guided Repeat Transsphenoidal Surgery for Previously Deemed Unresectable Lateral Disease in Acromegaly. Neurosurgical Focus. 2020 Jun;48(6):E8. PMID: 32480379.
Bernstein RM, O’Connor GK, Vance EA, Affara N, Drammeh S, Dunger DB, Faal A, Ong KK, Sosseh F, Prentice AM, Moore SE. Timing of the Infancy-Childhood Growth Transition in Rural Gambia. Frontiers of Endocrinology (Lausanne). 2020 Mar 24;11:142. PMID: 32265838 PMCID: PMC7105771.
Blackwell AKM, De-Loyde K, Brocklebank LA, Maynard OM, Marteau TM, Hollands GJ, Fletcher PC, Attwood AS, Morris RW, Munafò MR. Tobacco and electronic cigarette cues for smoking and vaping: an online experimental study. BMC Res Notes. 2020 Jan 15;13(1):32. PubMed PMID:31941548; PubMed Central PMCID: PMC6964108.
Blackwell AKM, De-Loyde K, Hollands GJ, Morris RW, Brocklebank LA, Maynard OM, Fletcher PC, Marteau TM, Munafò MR. The Impact on Selection of Non-Alcoholic vs Alcoholic Drink Availability: An Online Experiment. BMC Public Health. 2020 May 6;20(1):526. PMID: 32370760 PMCID: PMC7201696.
Blastland M, Freeman ALJ, van der Linden S, Marteau TM, Spiegelhalter D. Five rules for evidence communication. Nature. 2020 Nov;587(7834):362-364. doi: 10.1038/d41586-020-03189-1. PMID: 33208954.
Boughton C, Allen JM, Tauschmann M, Hartnell S, Wilinska ME, Musolino G, Acerini CL, Dunger PD, Campbell F, Ghatak A, Randell T, Besser R, Trevelyan N, Elleri D, Northam E, Hood K, Scott E, Lawton J, Roze S, Sibayan J, Kollman C, Cohen N, Todd J, Hovorka R; CLOuD Consortium. Assessing the effect of closed-loop insulin delivery from onset of type 1 diabetes in youth on residual beta-cell function compared to standard insulin therapy (CLOuD study): a randomised parallel study protocol. BMJ Open. 2020 Mar 12;10(3):e033500. PMID: 32169925; PMCID: PMC7069267.
Boughton CK, Hartnell S, Allen JM, Fuchs J, Hovorka R. Training and Support for Hybrid Closed -Loop Therapy. J Diabetes Sci Technol. 2020 Sep 11;1932296820955168. PMID: 32914648.
Boughton CK, Hovorka R. The artificial pancreas. Curr Opin Organ Transplant. 2020 Aug;25 (4):336-342. PMID: 32618719.
Braukmann F, Jordan D, Jenkins B, Koulman A, Miska EA. SID-2 negatively regulates develop- ment likely independent of nutritional dsRNA uptake. RNA Biol. 2020 Oct 12;1-12. PMID: 33044912.
Brierley GV, Webber H,2 Rasijeff E, Grocott S, Siddle K, Semple RK. Anti-Insulin Receptor Anti- bodies Improve Hyperglycemia in a Mouse Model of Human Insulin Receptoropathy. Diabetes 2020;69:1–9. PMID: 32816962.
Burton NO, Riccio C, Dallaire A, Price J, Jenkins B, Koulman A, Miska EA. Cysteine Synthases CYSL-1 and CYSL-2 Mediate C. Elegans Heritable Adaptation to P. Vranovensis Infection. Nature Communications. 2020 Apr 8;11(1):1741. PMID: 32269224 PMCID: PMC7142082.
Calderon G , McRae A, Rievaj J, Davis J, Zandvakili I, Linker-Nord S, Burton D, Roberts G, Reimann F, Gedulin B, Vella A, LaRusso NF, Camilleri M, Gribble FM, Acosta A. Ileo-Colonic Delivery of Conjugated Bile Acids Improves Glucose Homeostasis Via Colonic GLP-1-Producing Enteroendocrine Cells in Human Obesity and Diabetes. EbioMedicine Vol 55, May 2020:102759. PMID: 32344198, PMCID: PMC7186521.
Campbell, J. R., Martchenko, A., Sweeney, M. E., Maalouf, M. F., Psichas, A., Gribble, F. M., Reimann, F., Brubaker PL. Essential role of syntaxin-binding protein-1 in the regulation of glucagon-like peptide-1 secretion. Endocrinology. Volume 161, Issue 5, May 2020. PMID: 32141504.
Campi I, Covelli D, Moran C, Fugazzola L, Cacciatore C, Orlandi F, Gallone G, Chatterjee K, Beck-Peccoz P, Persani L. The Differential Diagnosis of Discrepant Thyroid Function Tests: Insistent Pitfalls and Updated Flow-Chart Based on a Long-Standing Experience. Front Endocrinol (Lausanne) 2020 Jul 7;11:432. PMID: 32733382. PMC7358450.
Chae H, Augustin R, Gatineau E, Mayoux E, Bensellam M, Antoine N, Khattab F, Lai BK, Brusa D, Stierstorfer B, Klein H, Singh B, Ruiz L, Pieper M, Mark M, Herrera PL, Gribble FM, Reimann F, Wojtusciszyn A, Broca C, Rita N, Piemonti L, Gilon P. SGLT2 is not expressed in pancreatic α – and β-cells, and its inhibition does not directly affect glucagon and insulin secretion in rodents and humans. Mol Metab. 2020 Sep 5;42:101071. PMID: 32896668.
Chalmers J, Tung YCL, Liu CH, O’Kane CJ, O’Rahilly S, Yeo GSH. A multi-component screen for feeding behaviour and nutritional status in Drosophila to interrogate mammalian appetite-related genes. Mol Metab
. 2020 Nov 23;101127. doi: 10.1016/j.molmet.2020.101127. PMID: 33242659 PMCID: PMC7753202
Cheng W, Gonzalez I, Pan W, Tsang A H, Adams J, Nkoda E, Gordian D, Khoury B, Roelofs K, Evers S, MacKinnon A, Wu S, Frikke-Schmidt H, Flak J N, Trevaskis J L, Rhodes C J, Fukada S, Seeley R J, Sandoval D A, Olson D P, Blouet C, and Myers, Jr M G. Calcitonin Receptor Neurons in the Mouse Nucleus Tractus Solitarius Control Energy Balance via the non-Aversive Suppression of Feeding. Cell Metab. 2020 Feb 4;31(2):301-312.e5. PubMed PMID: 31955990.
Chiesa ST, Marcovecchio ML, Benitez-Aguirre P, Cameron FJ, Craig ME, Couper JJ, Davis EA, Dalton RN, Daneman D, Donaghue KC, Jones TW, Mahmud FH, Marshall SM, Neil HAW, Dunger DB, Deanfield JE; Adolescent Type 1 Diabetes Cardio-Renal Intervention Trial (AdDIT) Study Group. Vascular Effects of ACE (Angiotensin-Converting Enzyme) Inhibitors and Statins in Adolescents With Type 1 Diabetes. Hypertension. 2020 Dec;76(6):1734-1743. doi: 10.1161/HYPERTENSIONAHA.120.15721. PMID: 33100044.
Clarke N, Pechey E, Mantzari E, Blackwell AKM, De-Loyde K, Morris RW, Munafò MR, Marteau TM, Hollands GJ. Impact of Health Warning Labels Communicating the Risk of Cancer on Alcohol Selection: An Online Experimental Study. Addiction. 2020 Apr 8. PMID: 32267588.
Clément K, van den Akker E, Argente J, Bahm A, Chung WK, Connors H, De Waele K, Farooqi IS, Gonneau-Lejeune J, Gordon G, Kohlsdorf K, Poitou C, Puder L, Swain J, Stewart M, Yuan G, Wabitsch M, Kühnen P; Setmelanotide POMC and LEPR Phase 3 Trial Investigators. Efficacy and safety of setmelanotide, an MC4R agonist, in individuals with severe obesity due to LEPR or POMC deficiency: single-arm, open-label, multicentre, phase 3 trials. Lancet Diabetes Endocrinol. 2020 Dec;8(12):960-970. doi: 10.1016/S2213-8587(20)30364-8. PMID: 33137293.
Coll AP, Chen M, Taskar P, Rimmington D, Patel S, Tadross JA, Cimino I, Yang M, Welsh P, Virtue S, Goldspink DA, Miedzybrodzka EL, Konopka AR, Esponda RR, Huang JT, Tung YCL, Rodriguez-Cuenca S, Tomaz RA, Harding HP, Melvin A, Yeo GSH, Preiss D, Vidal-Puig A, Vallier L, Nair KS, Wareham NJ, Ron D, Gribble FM, Reimann F, Sattar N, Savage DB, Allan BB, O’Rahilly S. Publisher Correction: GDF15 mediates the effects of metformin on body weight and energy balance. Nature. 2020 Feb;578(7796):E24. PMID: 32051582.
Colombo M, McGurnaghan SJ, Blackbourn LAK, Dalton RN, Dunger D, Bell S, Petrie JR, Green F, MacRury S, McKnight JA, Chalmers J, Collier A, McKeigue PM, Colhoun HM; Scottish Diabetes Research Network (SDRN) Type 1 Bioresource Investigators. Comparison of Serum and Urinary Biomarker Panels With Albumin/Creatinine Ratio in the Prediction of Renal Function Decline in Type 1 Diabetes. Diabetologia. 2020 Apr;63(4):788-798. PMID: 31915892 PMCID: PMC7054370.
Crabtree DR, Buosi W, Fyfe CL, Horgan GW, Manios Y, Androutsos O, Giannopoulou A, Finlayson G, Beaulieu K, Meek CL, Holst JJ, Van Norren KV, Mercer JG, Johnstone AM. Appetite Control across the Lifecourse: The Acute Impact of Breakfast Drink Quantity and Protein Content. The Full4Health Project. Nutrients. 2020 Nov 30;12(12):3710. doi: 10.3390/nu12123710. PMID:33266325 PMCID:PMC7759987
de Almeida-Faria J, Duque-Guimarães DE 1, Ong TP, Pantaleão LC, Carpenter AA, Loche E, Kusinski LC, Ashmore TJ, Antrobus R, Bushell M, Fernandez-Twinn DS, Ozanne SE. Maternal obesity during pregnancy leads to adipose tissue ER stress in mice via miR-126-mediated reduction in Lunapark. Diabetologia.
Dearden L, Buller S, Furigo IC, Fernandez-Twinn DS, Ozanne SE. Maternal obesity causes fetal hypothalamic insulin resistance and disrupts development of hypothalamic feeding pathways. Mol Metab. 2020 Sep 9;42:101079. PMID: 32919096 PMC7549144.
de Barros Mucci D, Kusinski LC, Wilsmore P, Loche E, Pantaleão LC, Ashmore TJ, Blackmore HL, Fernandez-Twinn DS, Carmo MDGTD, Ozanne SE. Impact of maternal obesity on placental transcriptome and morphology associated with fetal growth restriction in mice. Int J Obes (Lond). 2020 Mar 13. PMID:32203108.
Diederen KMJ, Fletcher PC. Dopamine, Prediction Error and Beyond. Neuroscientist. 2020 Apr 26:1073858420907591. PMID: 32338128.
Fisher BG, Thankamony A, Mendiola J, Petry CJ, Frederiksen H, Andersson AM, Juul A, Ong KK, Dunger DB, Hughes IA, Acerini CL. Maternal Serum Concentrations of Bisphenol A and Propyl Paraben in Early Pregnancy Are Associated With Male Infant Genital Development. Human Reproduction. 2020 Apr 28;35(4):913-928. PMID: 32325494.
Fleseriu M, Buchfelder M, Cetas JS, Fazeli PK, Mallea-Gil SM, Gurnell M, McCormack A, Pineyro MM, Syro LV, Tritos NA, Marcus HJ. Pituitary society guidance: pituitary disease management and patient care recommendations during the COVID-19 pandemic-an international perspective. Pituitary. 2020 Aug;23(4):327-337. PMID: 32556793. PMC7300368.
Fuchs J, Hovorka R. Closed-loop control in insulin pumps for type-1 diabetes mellitus: safety and efficacy. Expert Rev Med Devices. 2020 Jul 3;1-14. PMID: 32569476.
Fuchs J, Hovorka R. COVID-19 and Diabetes: Could Diabetes Technology Research Help Pave the Way for Remote Healthcare? Journal of Diabetes Science and Technology. 2020 May 30:1932296820929714. PMID: 32475169.
Furse S, Fernandez-Twinn DS, Jenkins B, Meek CL, Williams HEL, Smith GCS, CharnockJones DS, Ozanne SE, Koulman A. A high-throughput platform for detailed lipidomic analysis of a range of mouse and human tissues. Anal Bioanal Chem. 2020 Mar 7. Epub ahead of print. PMID: 32144454.
Furse S, Koulman A. Lipid extraction from dried blood spots and dried milk spots for untargeted high throughput lipidomics. Mol Omics. 2020 Sep 18. PMID: 32945330.
Furse S, Watkins AJ, Koulman A. Extraction of Lipids from Liquid Biological Samples for HighThroughput Lipidomics. Molecules. 2020 Jul 13;25(14):E3192. PMID: 32668693.
Galindo RJ, Umpierrez GE, Rushakoff RJ, Basu A, Lohnes S, Nichols JH, Spanakis EK, Espino- za J, Palermo NE, Awadjie DG, Bak L, Buckingham B, Cook CB, Freckmann G, Heinemann L, Hovorka R, Mathioudakis N, Newman T, O’Neal DN, Rickert M, Sacks DB, Seley JJ, Wallia A, Shang T, Zhang JY, Han J, Klonoff DC. Continuous Glucose Monitors and Automated Insulin Dosing Systems in the Hospital Consensus Guideline. J Diabetes Sci Technol. 2020 Sep 28;1932296820954163. PMID: 32985262.
Georgescu T, Lyons D, Doslikova B, Garcia AP, Marston O, Burke LK, Chianese R, Lam BYH, Yeo GSH, Rochford JJ, Garfield AS, Heisler LK. Neurochemical Characterization of Brainstem Pro-Opiomelanocortin Cells. Endocrinology. 2020 Apr 1;161(4). PMID: 32166324.
Gil A, Rueda R, Ozanne SE, van der Beek EM, van Loo-Bouwman C, Schoemaker M, Marinello V, Venema K, Stanton C, Schelkle B, Flourakis M, Edwards CA. Is there evidence for bacterial transfer via the placenta and any role in the colonization of the infant gut? – a systematic review. Crit Rev Microbiol. 2020 Aug 10;1-15. PMID: 32776793.
Giustina A, Barkhoudarian G, Beckers A, Ben-Shlomo A, Biermasz N, Biller B, Boguszewski C, Bolanowski M, Bollerslev J, Bonert V, Bronstein MD, Buchfelder M, Casanueva F, Chanson P, Clemmons D, Fleseriu M, Formenti AM, Freda P, Gadelha M, Geer E, Gurnell M, Heaney AP, Ho KKY, Ioachimescu AG, Lamberts S, Laws E, Losa M, Maffei P, Mamelak A, Mercado M, Molitch M, Mortini P, Pereira AM, Petersenn S, Post K, Puig-Domingo M, Salvatori R, Samson SL, Shimon I, Strasburger C, Swearingen B, Trainer P, Vance ML, Wass J, Wierman ME, Yuen KCJ, Zatelli MC, Melmed S. Multidisciplinary management of acromegaly: A consensus. Rev Endocr Metab Disord. 2020 Dec;21(4):667-678. PMID: 32914330.
Goh, K.J., Chen, J., Rocha, N. Semple, R.K. Human pluripotent stem cell-based models suggest preadipocyte senescence as a possible cause of metabolic complications of Werner and Bloom Syndromes. Scientific Reports. Vol 10, Article number: 7490 (2020). PMID: 32367056, PMC7198505.
Goldspink DA, Lu VB, Miedzybrodzka EL, Smith CA, Foreman RE, Billing LJ, Kay RG, *Reimann F, *Gribble FM (2020) Labelling and characterization of human GLP-1 secreting Lcells in primary ileal organoid culture. Cell Reports 2020 Jun 30;31(13):107833. doi: 10.1016/j.celrep.2020.107833. PMID: 32610134
Govaere O, Cockell S, Tiniakos D, Queen R, Younes R, Vacca M, Alexander L, Ravaioli F, Palmer J, Petta S, Boursier J, Rosso C, Johnson K, Wonders K, Day CP, Ekstedt M, Orešič M, Darlay R, Cordell HJ, Marra F, Vidal-Puig A, Bedossa P, Schattenberg JM, Clément K, Allison M, Bugianesi E, Ratziu V, Daly AK, Anstee QM. Transcriptomic profiling across the nonalcoholic fatty liver disease spectrum reveals gene signatures for steatohepatitis and fibrosis. Sci Transl Med. 2020 Dec 2;12(572):eaba4448. doi:10.1126/scitranslmed.aba4448. PMID: 33268509.
Groeneweg S, van Geest FS, Abacı A, Alcantud A, Ambegaonkar GP, Armour CM, Bakhtiani P, Barca D, Bertini ES, van Beynum IM, Brunetti-Pierri N, Bugiani M, Cappa M, Cappuccio G, Castellotti B, Castiglioni C, Chatterjee K, de Coo IFM, Coutant R, Craiu D, Crock P, DeGoede C, Demir K, Dica A, Dimitri P, Dolcetta-Capuzzo A, Dremmen MHG, Dubey R, Enderli A, Fairchild J, Gallichan J, George B, Gevers EF, Hackenberg A, Halász Z, Heinrich B, Huynh T, Kłosowska A, van der Knaap MS, van der Knoop MM, Konrad D, Koolen DA, Krude H, Lawson-Yuen A, Lebl J, Linder-Lucht M, Lorea CF, Lourenço CM, Lunsing RJ, Lyons G, Malikova J, Mancilla EE, McGowan A, Mericq V, Lora FM, Moran C, Müller KE, Oliver-Petit I, Paone L, Paul PG, Polak M, Porta F, Poswar FO, Reinauer C, Rozenkova K, Menevse TS, Simm P, Simon A, Singh Y, Spada M, van der Spek J, Stals MAM, Stoupa A, Subramanian GM, Tonduti D, Turan S, den Uil CA, Vanderniet J, van der Walt A, Wémeau JL, Wierzba J, de Wit MY, Wolf NI, Wurm M, Zibordi F, Zung A, Zwaveling-Soonawala N, Visser WE. Disease characteristics of MCT8 deficiency: an international, retrospective, multicentre cohort study. Lancet Diabetes Endocrinol. 2020 Jul;8 (7):594-605. PMID: 32559475.
Fang Z, Chen S, Manchanda Y, Bitsi S, Pickford P, David A, Shchepinova MM, Corrêa IR Jr, Hodson DJ, Broichhagen J, Tate EW, Reimann F, Salem V, Rutter GA, Tan T, Bloom SR, Tomas A, Jones B. Ligand-Specific Factors Influencing GLP-1 Receptor Post-Endocytic Trafficking and Degradation in Pancreatic Beta Cells. Int J Mol Sci. 2020 Nov 9;21(21):8404. doi: 10.3390/ijms21218404. PMID: 33182425 PMCID: PMC7664906
Haarsma J, Fletcher PC, Griffin JD, Taverne HJ, Ziauddeen H, Spencer TJ, Miller C, Katthagen T, Goodyer I, Diederen KMJ, Murray GK. Correction: Precision weighting of cortical unsigned prediction error signals benefits learning, is mediated by dopamine, and is impaired in psycho- sis. Mol Psychiatry. 2020 Oct 14. PMID: 33057170.
Hall Z, Chiarugi D, Charidemou E, Leslie J, Scott E, Pelligrinet L, Allison M, Mocciaro G, Anstee QM, Evan GI, Hoare M, Vidal-Puig A, Oakley F, Vacca M, Griffin JL. Lipid Remodelling in Hepatocyte Proliferation and Hepatocellular Carcinoma. Hepatology. 2020 May 27. PMID: 32460431.
Hammerle CM, Sandovici I, Brierley GV, Smith NM, Zimmer WE, Zvetkova I, Prosser HM, Sekita Y, Lam BYH, Ma M, Cooper WN, Vidal-Puig A, Ozanne SE, Medina-Gómez G, Constância M. Mesenchyme-derived IGF2 is a major paracrine regulator of pancreatic growth and function. PLoS Genet. 2020 Oct 15;16(10):e1009069. PMID: 33057429.
Herzig D, Studer D, Nakas CT, Kuenzli C, Stauffer TP, Hovorka R, Bally L. Effect of fully auto- mated closed-loop insulin delivery using faster aspart versus standard aspart on gluco- regulatory hormones in type 2 diabetes. Diabetes Obes Metab. 2020 Sep 9. PMID: 32902125.
Holt MK, Cook DR, Brierley DI, Richards JE, Reimann F, Gourine AV, Marina N, Trapp S. PPG Neurons in the Nucleus of the Solitary Tract Modulate Heart Rate but Do Not Mediate GLP-1 Receptor Agonist-Induced Tachycardia in Mice. Molecular Metabolism. 2020 May 21:101024. PMID: 32446875.
Hunter H, de Gracia Hahn D, Duret A, Ri Im Y, Cheah Q, Dong J, Fairey M, Hjalmarsson C, Li A, Kai Lim H, McKeown L, Mitrofan CG, Rao R, Utukuri M, Rowe IA, Mann JP. Weight loss, insulin resistance, and study design confound results in a meta-analysis of animal models of fatty liver. eLife 2020 Oct 16;9:e56573. doi: 10.7554/eLife.56573. PMID: 33063664 PMCID: PMC7647398.
Jenkins B, Ronis M, Koulman A. LC-MS Lipidomics: Exploiting a Simple High-Throughput Method for the Comprehensive Extraction of Lipids in a Ruminant Fat Dose-Response Study. Metabolites. 2020 Jul 17;10(7):296. PMID: 32709069. PMC7407148.
Jones KS, Parkington DA, Cox LJ, Koulman A. Erythrocyte transketolase activity coefficient (ETKAC) assay protocol for the assessment of thiamine status. Ann N Y Acad Sci. 2020 Dec 22. doi: 10.1111/nyas.14547. Epub ahead of print. PMID: 33354793.
Joustra SD, Roelfsema F, van Trotsenburg ASP, Schneider HJ, Kosilek RP, Kroon HM, Logan JG, Butterfield NC, Zhou X, Toufaily C, Bak B, Turgeon MO, Brûlé E, Steyn FJ, Gurnell M, Koulouri O, Le Tissier P, Fontanaud P, Duncan Bassett JH, Williams GR, Oostdijk W, Wit JM, Pereira AM, Biermasz NR, Bernard DJ, Schoenmakers N. IGSF1 Deficiency Results in Human and Murine Somatotrope Neurosecretory Hyperfunction. J Clin Endocrinol Metab. 2020 Mar 1;105 (3). PubMed PMID: 31650157.
Joustra SD, Roelfsema F, Paul van Trotsenburg AS, Schneider HJ, Kosilek RP, Kroon HM, Logan JG, Butterfield NC, Zhou X, Toufaily C, Bak B, Turgeon MO, Brûlé E, Steyn FJ, Gurnell M, Koulouri O, Le Tissier P, Fontanaud P, Bassett JHD, Williams GR, Oostdijk W, Wit JM, Pereira AM, Biermasz NR, Bernard DJ, Schoenmakers N. Response to Letter to the Editor: IGSF1 Deficiency Results in Human and Murine Somatotrope Neurosecretory Hyperfunction. J Clin Endocrinol Metab. 2020 Mar 24. PMID: 32211768
Joustra SD, Roelfsema F, van Trotsenburg ASP, Schneider HJ, Kosilek RP, Kroon HM, Logan JG, Butterfield NC, Zhou X, Toufaily C, Bak B, Turgeon MO, Brûlé E, Steyn FJ, Gurnell M, Koulouri O, Le Tissier P, Fontanaud P, Bassett JHD, Williams GR, Oostdijk W, Wit JM, Pereira AM, Biermasz NR, Bernard DJ, Schoenmakers N. Response to Letter to the Editor: “IGSF1 Deficiency Results in Human and Murine Somatotrope Neurosecretory Hyperfunction”. Journal of Clinical Endocrinology and Metabolism. 2020 Jun 1;105(6):dgaa147. PMID: 32211768 PMCID: PMC7159029.
Kanakis I, Alameddine M, Scalabrin M, van ‘t Hof RJ, Liloglou T, Ozanne SE, Goljanek-Whysall K, Vasilaki A. Low protein intake during reproduction compromises the recovery of lactationinduced bone loss in female mouse dams without affecting skeletal muscles. FASEB J. 2020 Jul 11. PMID: 32652768.
Kay RG, Foreman RE, Roberts GP, Hardwick R, Reimann F, Gribble FM. Mass Spectrometric Characterisation of the Circulating Peptidome Following Oral Glucose Ingestion in Control and Gastrectomised Patients. Rapid Communications in Mass Spectrometry. 2020 Jun 3:e8849. PMID: 32492232.
Khoo S, Lyons G, McGowan A, Gurnell M, Oddy S, Visser WE, van den Berg S, Halsall D, Taylor K, Chatterjee K, Moran C. Familial dysalbuminaemic hyperthyroxinemia interferes with current free thyroid hormone immunoassay methods. Eur J Endocrinol. 2020 Mar 1. PMID: 32213658.
Khoo S, Lyons G, McGowan A, Gurnell M, Oddy S, Visser WE, van den Berg S, Halsall D, Taylor K, Chatterjee K, Moran C. Familial Dysalbuminaemic Hyperthyroxinaemia Interferes With Current Free Thyroid Hormone Immunoassay Methods. European Journal of Endocrinology. 2020 Jun;182(6):533-538. PMID: 32213658 PMCID: PMC7222281.
Khoo S, Lyons G, Solomon A, Oddy S, Halsall D, Chatterjee K, Moran C. Familial dysalbuminemic hyperthyroxinemia confounding management of coexistent autoimmune thyroid disease. Endocrinol Diabetes Metab Case Rep. 2020 Feb 26;2020. PMID: 32101523.
Kohnke S, Meek CL. Don’t seek, don’t find: the diagnostic challenge of Wernicke’s encephalopathy. Ann Clin Biochem. 2020 Jul13;PMID: 32551830
Kolias A, Tysome J, Donnelly N, Sharma R, Gkrania-Klotsas E, Budohoski K, Karcheva S, Adapa R, Lawes I, Gurnell M, Hutchinson P, Bance M, Axon P, Santarius T, Mannion RJ. A Safe Approach to Surgery for Pituitary and Skull Base Lesions During the COVID-19 Pandemic. Acta Neurochirurgica (Wien). 2020 May 9:1-3. PMID: 32388681 PMCID: PMC7211050.
Krycer JR, Elkington SD, Diaz-Vegas A, Cooke KC, Burchfield JG, Fisher-Wellman KH, Cooney GJ, Fazakerley DJ, James DE. Mitochondrial Oxidants, but Not Respiration, Are Sensitive to Glucose in Adipocytes. Journal of Biological Chemistry. 2020 Jan 3;295(1):99-110. PMID: 31744882 PMCID: PMC6952605.
Kusinski LC, Murphy HR, Rolfe EL, Rennie KL, Griep LMO, Hughes D, Taylor R, Meek CL. Erratum: Dietary Intervention in Pregnant Women with Gestational Diabetes; Protocol for the DiGest Randomised Controlled Trial; Nutrients 2020, 12, 1165. Nutrients. 2020 Jun 17;12(6):1793. doi: 10.3390/nu12061793. PMID:32560576 PMCID:PMC7353399
Kwok A, Zvetkova I, Virtue S, Luijten I, Huang-Doran I, Tomlinson P, Bulger DA, West J, Murfitt S, Griffin J, Alam R, Hart D, Knox R, Voshol P, Vidal-Puig A, Jensen J, O’Rahilly S, Semple RK. Truncation of Pik3r1 Causes Severe Insulin Resistance Uncoupled From Obesity and Dyslipidemia by Increased Energy Expenditure. Molecular Metabolism. 2020 May 18:101020. PMID: 32439336.
Lachmann EH, Fox RA, Dennison RA, Usher-Smith JA, Meek CL, Aiken CE. Barriers to completing oral glucose tolerance testing in women at risk of gestational diabetes. Diabet Med. 2020 Sep;37(9):1482-1489. doi: 10.1111/dme.14292. PMID:32144795
Langfield T, Pechey R, Pilling MA, Marteau TM. Glassware design and drinking behaviours: a review of impact and mechanisms using a new typology of drinking behaviours. Health Psychol Rev. 2020 Nov 18;1-23. doi: 10.1080/17437199.2020.1842230. PMID: 33140699.
Lawler K, Huang-Doran I, Sonoyama T, Collet TH, Keogh JM, Henning E, O’Rahilly S, Bottolo L, Farooqi IS. Leptin-mediated Changes in the Human Metabolome. Journal of Clinical Endocrinology and Metabolism. Volume 105, Issue 8, August 2020. PMID: 32392278.
Leelarathna L, Thabit H, Hovorka R, Evans M. Estimated HbA 1c and glucose management indi- cator (GMI): are they the same? Diabet Med. 2020 Oct 15;e14423. PMID: 33058254.
Lewis JE, Miedzybrodzka EL, Foreman RE, Woodward ORM, Kay RG, Goldspink DA, Gribble FM, Reimann F. Selective stimulation of colonic L cells improves metabolic outcomes in mice. Diabetologia. 2020 Apr 27. PMID: 32342115.
Leelarathna L, Thabit H, Willinska ME, Bally L, Mader JK, Arnolds S, Benesch C, Pieber TR, Shah VN, Carlson AL, Bergenstal RM, Evans ML, Hovorka R; AP@home04 and APCam11 consortia. Duration of Hybrid Closed-Loop Insulin Therapy to Achieve Representative Glycemic Outcomes in Adults With Type 1 Diabetes. Diabetes Care. 2020 Jan 16. pii: dc192041. Epub ahead of print. PubMed PMID: 31949086.
Liang ZS, Cimino I, Yalcin B, Raghupathy N, Vancollie VE, Ibarra-Soria X, Firth HV, Rimmington D, Farooqi IS, Lelliott CJ, Munger SC, O’Rahilly S, Ferguson-Smith AC, Coll, Logan DW. Trappc9 deficiency causes parent-of-origin dependent microcephaly and obesity. Plos Genetics. 2020 Sept 2. PMID: 32877400 PMC7467316.
Lockhart S, O’Rahilly S. When two pandemics meet: Why is obesity associated with increased COVID-19 mortality. Med. 25 June 2020.
Lockhart SM, Saudek V, O’Rahilly S. GDF15: A hormone conveying somatic distress to the brain. Endocrine Reviews. Vol 41 Issue 4 2020 Apr 20. PMID: 32310257. Lockhart SM, O’Rahilly S. The wasting hormone GDF15 frees up fat to fight infection. Nature Metabolism 2019;1:935-936 (news and views).
Löfvenborg JE, Carlsson S, Andersson T, Hampe CS, Koulman A, Chirlaque Lopez MD, Jakszyn P, Katzke VA, Kühn T, Kyrø C, Masala G, Nilsson PM, Overvad K, Panico S, Sánchez MJ, van der Schouw Y, Schulze MB, Tjønneland A, Weiderpass E, Riboli E, Forouhi NG, Sharp SJ, Rolandsson O, Wareham NJ. Interaction Between GAD65 Antibodies and Dietary Fish Intake or Plasma Phospholipid n-3 Polyunsaturated Fatty Acids on Incident Adult-Onset Diabetes: The EPIC-InterAct Study. Diabetes Care. 2020 Dec 10;dc201463. doi: 10.2337/dc20-1463. PMID: 33303636.
Lund ML , Sorrentino G, Egerod KL, Kroone C, Mortensen B, Knop FK, Reimann F, Gribble FM, Drucker DJ, de Koning EJP, Schoonjans K, Bäckhed F, Schwartz TW, Petersen N (2020) L-cell differentiation is induced by bile acids through GLP-1 and paracrine serotonin signaling. Diabetes 2020 Apr;69(4):614-623. doi: 10.2337/db19-0764. Epub 2020 Feb 10. PMID: 32041793 PMCID: PMC7224989
MacFarlane J, Bashari WA, Senanayake R, Gillett D, van der Meulen M, Powlson AS, Kolias A, Koulouri O, Gurnell M. Advances in the Imaging of Pituitary Tumors. Endocrinol Metab Clin North Am. 2020 Sep;49(3):357-373. PMID: 32741476.
Magee LA, Banerjee A, Coleman MA, von Dadelszen P, Denison F, Farmer A, Finer S, FoxRushby J, Holt R, Lindsay RS, MacKillop L, Maresh M, McAuliffe FM, McCance D, McCarthy FP, Meek CL, Murphy HR, Myers J, Pasupathy D, Poston L, Reynolds RM, Saravanan P, Scott E, Sukumar N, Tan B, Thangaratinam S, Webster L, White SL, Williamson C. Gestational Diabetes Mellitus: An opportunity to improve long term health in mothers and children. Lancet Diabetes and Endocrinology. ISSN 2213-8587 (In Press)
Mahú I, Barateiro A, Rial-Pensado E, Martinéz-Sánchez N, Vaz SH, Cal PMSD, Jenkins B, Rodrigues T, Cordeiro C, Costa MF, Mendes R, Seixas E, Pereira MMA, Kubasova N, Gres V, Morris I, Temporão C, Olivares M, Sanz Y, Koulman A, Corzana F, Sebastião AM, López M, Bernardes GJL, Domingos AI. Brain-Sparing Sympathofacilitators Mitigate Obesity Without Adverse Cardiovascular Effects. Cell Metabolism. 2020 Jun 2;31(6):1120-1135.e7. PMID: 32402266.
Marcovecchio ML, Colombo M, Dalton RN, McKeigue PM, Benitez-Aguirre P, Cameron F, Chiesa ST, Couper J, Craig M, Daneman D, Davis E, Deanfield J, Donaghue K, Jones TW, Mahmud FH, Marshall SM, Neil HAW, Colhoun HM, Dunger DB; AdDIT and the SDRNT1BIO Investigators. Biomarkers associated with early stages of kidney disease in adolescents with type 1 diabetes. Pediatr Diabetes. 2020 Aug 11. PMID: 32783254.
Marcovecchio ML, Gorman S, Watson LPE, Dunger DB, Beardsall K. Catch-Up Growth in Children Born Small for Gestational Age Related to Body Composition and Metabolic Risk at Six Years of Age in the UK. Horm Res Paediatr. 2020 Jul 23;93(2):119-127. PMID: 32702692.
Marcovecchio ML, Wicker LS, Dunger DB, Dutton SJ, Kopijasz S, Scudder C, Todd JA, Johnson PRV. Interleukin-2 Therapy of Autoimmunity in Diabetes (ITAD): A Phase 2, Multicentre, DoubleBlind, Randomized, Placebo-Controlled Trial. Wellcome Open Res. 2020 Mar 20;5:49. PMID: 32399500. PMCID: PMC7194454.
Marenne G, Hendricks AE, Perdikari A, Bounds R, Payne F, Keogh JM, Lelliott CJ, Henning E, Pathan S, Ashford S, Bochukova EG, Mistry V, Daly A, Hayward C; INTERVAL, UK10K Consortium, Wareham NJ, O’Rahilly S, Langenberg C, Wheeler E, Zeggini E, Farooqi IS, Barroso I. Exome Sequencing Identifies Genes and Gene Sets Contributing to Severe Childhood Obesity, Linking PHIP Variants to Repressed POMC Transcription. Cell Metabolism. 2020 Jun 2;31 (6):1107-1119.e12. PMID: 32492392.
Marques P, Caimari F, Hernández-Ramírez LC, Collier D, Iacovazzo D, Ronaldson A, Magid K, Lim CT, Stals K, Ellard S, Grossman AB, Korbonits M; FIPA Consortium. Significant Benefits of AIP Testing and Clinical Screening in Familial Isolated and Young-onset Pituitary Tumors. Journal of Clinical Endocrinology and Metabolism. 2020 Jun 1;105(6):dgaa040. PMID: 31996917 PMCID: PMC7137887.
Mazarello Paes V, Barrett JK, Dunger DB, Gevers EF, Taylor-Robinson DC, Viner RM, Stephenson TJ. Factors predicting poor glycemic control in the first two years of childhood onset type 1 diabetes in a cohort from East London, UK: Analyses using mixed effects fractional polynomial models. Pediatr Diabetes. 2020 Mar;21(2):288-299. Epub 2019 Dec 17. PubMed PMID:31782879.
Meek CL, Devoy B, Simmons D, Patient CJ, Aiken AR, Murphy HR, Aiken CE. Seasonal variations in incidence and maternal-fetal outcomes of gestational diabetes. Diabet Med. 2020 Apr;37(4):674-680. doi: 10.1111/dme.14236. PMID:31955458
Meek CL, Lewis HB, Burling K, Reimann F, Gribble F. Expected values for gastrointestinal and pancreatic hormone concentrations in healthy volunteers in the fasting and postprandial state. Ann Clin Biochem. 2020 Dec 7;4563220975658. doi: 10.1177/0004563220975658. PMID: 33175577.
Meek CL, Lindsay RS, Scott EM, Aiken CE, Myers J, Reynolds R, Simmons D, Yamamoto JM, McCance DR, Murphy HR. Approaches to screening for hyperglycaemia in pregnant women during and after the Covid-19 pandemic. Diabet Med. 2020 Aug 4. PMID: 32750184
Melvin A, Cowan C, Lam B, Buller S, Rainbow K, Yeo GS, O’Rahilly S. SUN-LB107 Functional Characterisation of Human Heterozygous Non-Synonymous MC3R Variants. Journal of the Endocrine Society, Volume 4, Issue Supplement_1, April-May 2020.
Miedzybrodzka EL, Foreman RE, Galvin SG, Larraufie P, George AL, Goldspink DA, Reimann F, Gribble FM, Kay RG. Organoid Sample Preparation and Extraction for LC-MS Peptidomics. STAR Protoc. 2020 Nov 25;1(3):100164. doi: 10.1016/j.xpro.2020.100164. PMID:33377058 PMCID:PMC7757358
Mlcochova P, Collier D, Ritchie A, Assennato SM, Hosmillo M, Goel N, Mend B, Chatterjee K, Mendoza V, Temperton N, Kiss L, James LC, Ciazynska KA, Xiong X, Briggs JAG, Nathan JA, Mescia F, Bergamaschi L, Zhang H, Barmpounakis P, Demeris N, Skells R, Lyons PA, Bradley J, Baker S, Allain JP, Smith KGC, Bousfield R, Wilson M, Sparkes D, Amoroso G, Gkrania-Klotsas E, Hardwick S, Boyle A, Goodfellow I, Gupta RK. Combined point-of-care nucleic acid and antibody testing for SARS-COV2 following emergence of D614G spike variant. Cell Reports Medicine 2020; doi: 10.1016/j.xcrm.2020.100099. PMID:32905045 PMCID:PMC7462534
Modvig I, Andersen D, Grunddal K, Kuhre RE, Martinussen C, Christiansen C, Ørskov C, Larraufie P, Kay RG, Reimann F, Gribble FM, Hartmann B, Bojsen-Møller K, Madsbad S, Wewer Albrechtsen N, Holst JJ (2020) Secretin release after Roux-en-Y Gastric Bypass reveals a population of glucose-sensitive S-cells in distal small intestine. Int J Obes (Lond). 2020 Feb 3. doi: 10.1038/s41366-020-0541-7. PMID: 32015474
Montagnese M, Knolle F, Haarsma J, Griffin JD, Richards A, Vertes PE, Kiddle B, Fletcher PC, Jones PB, Owen MJ, Fonagy P, Bullmore ET, Dolan RJ; NSPN Consortium, Moutoussis M, Goodyer IM, Murray GK. Reinforcement Learning as an Intermediate Phenotype in Psychosis? Deficits Sensitive to Illness Stage but Not Associated With Polygenic Risk of Schizophrenia in the General Population. Schizophrenia Research. 2020 May 7:S0920-9964(20)30229-2. PMID: 32389614.
Moran C, Seger C, Taylor K, Oddy S, Burling K, Rajanayagam O, Fairall L, McGowan AN, Lyons G, Halsall D, Gurnell M, Schwabe J, Chatterjee VK, Strey C. HYPERTHYROXINEMIA AND HYPERCORTISOLEMIA DUE TO FAMILIAL DYSALBUMINEMIA. Thyroid. 2020 Jul 15. PMID: 32669045.
Napier C, Gan EH, Mitchell AL, Gilligan LC, Rees DA, Moran C, Chatterjee K, Vaidya B, James RA, Mamoojee Y, Ashwell S, Arlt W, Pearce SHS. Residual Adrenal Function in Autoimmune Addison’s Disease-Effect of Dual Therapy With Rituximab and Depot Tetracosactide. J Clin Endocrinol Metab. 2020 Apr 1;105(4). PMID: 31863094. PMCID: PMC7067544.
Niechciał E, Acerini CL, Chiesa ST, Stevens T, Dalton RN, Daneman D, Deanfield JE, Jones TW, Mahmud FH, Marshall SM, Neil HAW, Dunger DB, Marcovecchio ML; Adolescent Type 1 Diabetes Cardio-Renal Intervention Trial (AdDIT) Study Group; Medication Adherence During Adjunct Therapy With Statins and ACE Inhibitors in Adolescents With Type 1 Diabetes. Diabetes Care. 2020 May;43(5):1070-1076. PMID: 32108022.
Nicholas, L., Nagao, M., Kusinski, L., Twinn, D., Eliasson, L., & Ozanne, S. (2020). Exposure to maternal obesity programs sex differences in pancreatic islets of the offspring in mice. Diabetologia, 63 (2), 324-337. PMID: 31773193. PMCID: PMC6946752.
Ong KK, Cheng TS, Olga L, Prentice PM, Petry CJ, Hughes IA, Dunger DB. Which Infancy Growth Parameters Are Associated With Later Adiposity? The Cambridge Baby Growth Study. Annals of Human Biology. 2020 Mar;47(2):142-149. PMID: 32429763.
Petry CJ, Ong KK, Hughes IA, Dunger DB. Multiple Micronutrient Supplementation during Pregnancy and Increased Birth Weight and Skinfold Thicknesses in the Offspring: The Cambridge Baby Growth Study. Nutrients. 2020 Nov 12;12(11):3466. doi: 10.3390/nu12113466. PMID: 33198145 PMCID: PMC7697774.
Prins D, Park HJ, Watcham S, Li J, Vacca M, Bastos HP, Gerbaulet A, Vidal-Puig A, Göttgens B, Green AR. The stem/progenitor landscape is reshaped in a mouse model of essential thrombocythemia and causes excess megakaryocyte production. Sci Adv. 2020 Nov 25;6(48):eabd3139. doi: 10.1126/sciadv.abd3139. PMID: 33239297 PMCID: PMC7688335
Razolli DS, de Araújo TM, Sant Apos Ana MR, Kirwan P, Cintra DE, Merkle FT, Velloso LA. Proopiomelanocortin Processing in the Hypothalamus Is Directly Regulated by Saturated Fat: Implications for the Development of Obesity. Neuroendocrinology. 2020;110(1-2):92-104. Epub 2019 May20. PubMed PMID: 31104058.
Quinn M, Bashari W, Smith D, Gurnell M, Agha A. A remarkable case of thyrotoxicosis initially caused by graves’ disease followed by a probable TSHoma – a case report. BMC Endocr Disord. 2020 Aug 27;20(1):133. PMID: 32854689 PMC7457301.
Reimann, F., Lewis, J. E., Miedzybrodzka, E. L., Foreman, R. E., Woodward, O. R., Kay, R. G., Goldspink, D. A., & et al. Selective stimulation of colonic L-cells improves metabolic outcomes in mice. Diabetologia. 2020 Jul;63(7):1396-1407. doi: 10.1007/s00125-020-05149-w. Epub 2020 Apr 27. PMID: 32342115 PMCID: PMC7286941
Roseboom TJ, Ozanne SE, Godfrey KM, Isasi CR, Itoh H, Simmons R, Bansal A, Barker M, Plosch T, Sloboda DM, Matthews SG, Fall CHD, Poston L, Hanson MA. Unheard, unseen and unprotected: DOHaD council’s call for action to protect the younger generation from the long- term effects of COVID-19. J Dev Orig Health Dis. 2020 Sep 23;1-3. PMID: 32962780.
Roth E, Benoit S, Quentin B, Lam B, Will S, Ma M, Heeley N, Darwish T, Shrestha Y, Gribble F, Reimann F, Pshenichnaya I, Yeo G, Baker DJ, Trevaskis JL, Blouet C. Behavioural and neurochemical mechanisms underpinning the feeding-suppressive effect of GLP-1/CCK combinatorial therapy. Mol Metab. 2020 Nov 19;43:101118. doi: 10.1016/j.molmet.2020.101118. PMID: 33221554 PMCID: PMC7720077.
Rowitch DH, O’Rahilly S, Smith GCS. A classification of video-conferencing related illness: the zoomnotic diseases. QJM. 2020 Nov 27;hcaa316. doi: 10.1093/qjmed/hcaa316. PMID: 33245119
Rubio C, Puerto M, García-Rodríquez JJ, Lu VB, García-Martínez I, Alén R, Sanmartín-Salinas P, Toledo-Lobo MV, Saiz J, Ruperez J, Barbas C, Menchén L, Gribble FM, Reimann F, Guijarro LG, Carrascosa JM, Valverde ÁM. Impact of global PTP1B deficiency on the gut barrier permeability during NASH in mice. Mol Metab. 2020 Feb 6;35:100954. PMID: 32244182. PMCID: PMC7082558.
Sam AH, Reid MD, Thakerar V, Gurnell M, Westacott R, Reed MWR, Brown CA. National inter-rater agreement of standardised simulated-patient-based assessments. Med Teach. 2020 Nov 16;1-6. doi: 10.1080/0142159X.2020.1845909. PMID: 33198538.
Samuelson I, Vidal-Puig A. Studying Brown Adipose Tissue in a Human in vitro Context. Front Endocrinol (Lausanne). 2020 Sep 15;11:629. PMID: 33042008 PMC7523498.
Sarnobat D, Moffett C R, Gault V A, Tanday N, Reimann F, Gribble F M, Flatt P R, Irwin N. Effects of long-acting GIP, xenin and oxyntomodulin peptide analogues on alpha-cell transdifferentiation in insulin-deficient diabetic GluCreERT2;ROSA26-eYFP mice. Peptides. 2020 Mar;125:170205 Review. PMID: 31738969 PMCID: PMC7212078
Sarnobat D, Moffett CR, Tanday N, Reimann F, Gribble FM, Flatt PR, Tarasov AI. Antidiabetic drug therapy alleviates type 1 diabetes in mice by promoting pancreatic α-cell transdifferentia- tion. Biochem Pharmacol. 2020 Sep 11;182:114216. PMID: 32926875.
Schoenmakers E, Chatterjee K. Human disorders affecting the selenocysteine incorporation pathway cause systemic selenoprotein deficiency. Antioxididants and Redox Signalling. 2020 May 11. PMID: 32295391.
Smith LE, Mottershaw AL, Egan M, Waller J, Marteau TM, Rubin GJ. The impact of believing you have had COVID-19 on self-reported behaviour: Cross-sectional survey. PLoS One. 2020 Nov 4;15(11):e0240399. doi: 10.1371/journal.pone.0240399. PMID: 33147219 PMCID: PMC7641362
Snowden SG, Fernandes HJR, Kent J, Foskolou S, Tate P, Field SF, Metzakopian E, Koulman A. Development and Application of High-Throughput Single Cell Lipid Profiling: A Study of SNCA-A53T Human Dopamine Neurons. iScience. 2020 Oct 21;23(11):101703. doi: 10.1016/j.isci.2020.101703. eCollection 2020 Nov 20. PMID: 33196026 PMCID: PMC7644967.
Snowden SG, Korosi A, de Rooij SR, Koulman A. Combining lipidomics and machine learning to measure clinical lipids in dried blood spots. Metabolomics. 2020 Jul 24;16(8):83. PMID: 32710150. PMC7381462.
Sonoyama T, Stadler LKJ, Zhu M, Keogh JM, Henning E, Hisama F, Kirwan P, Jura M, Blaszczyk BK, DeWitt DC, Brouwers B, Hyvönen M, Barroso I, Merkle FT, Appleyard SM, Wayman GA, Farooqi IS. Human BDNF/TrkB Variants Impair Hippocampal Synaptogenesis and Associate With Neurobehavioural Abnormalities. Scientific Reports. 2020 Jun 3;10(1):9028. PMID: 32493978.
Suehs CM, Menzies-Gow A, Price D, Bleecker ER, Canonica GW, Gurnell M, Bourdin A; Oral Corticosteroids Tapering Delphi Expert Panel. Expert Consensus on the Tapering of Oral Corticosteroids for the Treatment of Asthma: A Delphi Study. Am J Respir Crit Care Med. 2020 Oct 28. doi: 10.1164/rccm.202007-2721OC. PMID: 33112646.
Sullivan SA, Kounali D, Cannon M, David AS, Fletcher PC, Holmans P, Jones H, Jones PB, Linden DEJ, Lewis G, Owen MJ, O’Donovan M, Rammos A, Thompson A, Wolke D, Heron J, Zammit S. A Population-Based Cohort Study Examining the Incidence and Impact of Psychotic Experiences From Childhood to Adulthood, and Prediction of Psychotic Disorder. Am J Psychiatry. 2020 Jan 7. Epub ahead of print. PubMed PMID: 31906710.
Tarry-Adkins JL, Aiken CE, Ozanne SE. Comparative Impact of Pharmacological Treatments for Gestational Diabetes on Neonatal Anthropometry Independent of Maternal Glycaemic Control: A Systematic Review and Meta-Analysis. PLoS Med. 2020 May 22;17(5):e1003126. PMID: 32442232 PMCID: PMC7244100.
Teufel C, Fletcher PC. Publisher Correction: Forms of prediction in the nervous system. Nat Rev Neurosci. 2020 Mar 27. PMID: 32221470
Teufel C, Fletcher PC. Forms of prediction in the nervous system. Nat Rev Neurosci. 2020 Apr;21(4):231-242. Epub 2020 Mar 10. Review. Erratum in: Nat Rev Neurosci. 2020 Mar 27. PMID: 32157237.
Teulings NEWD, Wood AM, Sovio U, Ozanne SE, Smith GCS, Aiken CE. Independent influences of maternal obesity and fetal sex on maternal cardiovascular adaptation to pregnancy: a prospective cohort study. Int J Obes (Lond). 2020 Jun 15. PMID: 32765423. PMC7381236.
Thackray AM, Lam B, Shahira Binti Ab Razak A, Yeo G, Bujdoso R. Transcriptional signature of prion-induced neurotoxicity in a Drosophila model of transmissible mammalian prion disease. Biochem J. 2020 Feb 28;477(4):833-852. PMID: 32108870.
Tsang AH, Nuzzaci D, Darwish T, Samudrala H, Blouet C. Nutrient sensing in the nucleus of the solitary tract mediates non-aversive suppression of feeding via inhibition of AgRP neurons. Mol Metab. 2020 Sep 6;42:10107. PMID: 32898712 PMC7549147.
Tung L, O’Rahilly S. Constitutional Thinness: tALKing the tALK or wALKing the wALK? Cell Metabolism, 01 Jul 2020, 32(1):8-10. PMID: 32640247.
Uter J, Heldmann M, Rogge B, Obst M, Steinhardt J, Brabant G, Moran C, Chatterjee K, Münte TF. Patients with mutations of the Thyroid hormone beta-receptor show an ADHD-like phenotype for performance monitoring: an electrophysiological study. Neuroimage Clin. 2020 Mar 19;26:102250. PMID: 32217468.
Vacca M, Leslie J, Virtue S, Lam BYH, Govaere O, Tiniakos D, Snow S, Davies S, Petkevicius K, Tong Z, Peirce V, Nielsen MJ, Ament Z, Li W, Kostrzewski T, Leeming DJ, Ratziu V, Allison MED, Anstee QM, Griffin JL, Oakley F, Vidal-Puig A. Bone morphogenetic protein 8B promotes the progression of non-alcoholic steatohepatitis. Nat Metab. 2020 Jun;2(6):514-531. PMID: 32694734.
Vergari E, Denwood G, Salehi A, Zhang Q, Adam J, Alrifaiy A, Wernstedt Asterholm I, Benrick A, Chibalina MV, Eliasson L, Guida C, Hill TG, Hamilton A, Ramracheya R, Reimann F, Rorsman NJG, Spilliotis I, Tarasov AI, Walker JN, Rorsman P, Briant LJB. Somatostatin secretion by Na(+)-dependent Ca(2+)-induced Ca(2+) release in pancreatic delta-cells. Nat Metab. 2020 Jan;2(1):32-40. Epub 2020 Jan 20. PubMed PMID: 31993555; PubMed Central PMCID: PMC6986923.
Vogelezang S, [31 authors], Farooqi IS, [110 authors]; Early Growth Genetics Consortium, Jad- doe VWV, Grant SFA, Felix JF. Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits. PLoS Genet. 2020 Oct 12;16(10):e1008718. PMID: 33045005.
von Schnurbein J, Adams C, Akinci B, Ceccarini G, D’Apice MR, Gambineri A, Hennekam RCM, Jeru I, Lattanzi G, Miehle K, Nagel G, Novelli G, Santini F, SantosSilva E, Savage DB, Sbraccia P, Schaaf J, Sorkina E, Tanteles G, Vantyghem MC, Vatier C, Vigouroux C, Vorona E, AraújoVilar D, Wabitsch M. European lipodystrophy registry: background and structure. Orphanet J Rare Dis. 2020 Jan 15;15(1):17. PubMed PMID: 31941540; PubMed Central PMCID: PMC6964101.
Wagstyl K, Larocque S, Cucurull G, Lepage C, Cohen JP, Bludau S, Palomero-Gallagher N, Lewis LB, Funck T, Spitzer H, Dickscheid T, Fletcher PC, Romero A, Zilles K, Amunts K, Bengio Y, Evans AC. BigBrain 3D Atlas of Cortical Layers: Cortical and Laminar Thickness Gradients Diverge in Sensory and Motor Cortices. PLoS Biol. 2020 Apr 3;18(4):e3000678. PMID: 32243449 PMCID: PMC7159250.
Wallis N, Raffan E. The Genetic Basis of Obesity and Related Metabolic Diseases in Humans and Companion Animals. Genes (Basel). 2020 Nov 20;11(11):1378. doi: 10.3390/genes11111378. PMID:33233816 PMCID:PMC7699880
Warde KM, Schoenmakers E, Ribes Martínez E, Lim YJ, Leonard M, Lawless SJ, O’Shea P, Chatterjee VK, Gurnell M, Hantel C, Dennedy MC. Liver X receptor inhibition potentiates mitotane induced adrenotoxicity in ACC. Endocrine Related Cancer. Vol 27 (Issue 6) pp 361-373. 2020 June. PMID: 32276262.
Wargent ET, Martin-Gronert MS, Cripps RL, Heisler LK, Yeo GSH, Ozanne SE, Arch JRS, Stocker CJ. Developmental programming of appetite and growth in male rats increases hypothalamic serotonin (5-HT)5A receptor expression and sensitivity. Int J Obes (Lond). 2020 Jul 27. PMID: 32719434.
Webb TL, du Plessis H, Christian H, Raffan E, Rohlf V, White GA. Understanding obesity among companion dogs: New measures of owner’s beliefs and behaviour and associations with body condition scores. Prev Vet Med. 2020 Jul;180:105029. doi: 10.1016/j.prevetmed.2020. PMID:32474335
Westwater ML, Mancini F, Shapleske J, Serfontein J, Ernst M, Ziauddeen H, Fletcher PC. Dissociable Hormonal Profiles for Psychopathology and Stress in Anorexia and Bulimia Nervosa. Psychological Medicine. 2020 May 28:1-11. PMID: 32460904.
Wood CL, Cole M, Donaldson M, Dunger DB, Wood R, Morrison N, Matthews JNS, Pearce SHS, Cheetham TD. Randomised trial of block and replace vs dose titration thionamide in young people with thyrotoxicosis. Eur J Endocrinol. 2020 Dec;183(6):637-645. doi: 10.1530/EJE-20-0617. PMID: 33107439.
Worth AA, Shoop R, Tye K, Feetham CH, D’Agostino G, Dodd GT, Reimann F, Gribble FM, Beebe EC, Dunbar JD, Alexander-Chacko JT, Sindelar DK, Coskun T, Emmerson PJ, Luckman SM. The cytokine GDF15 signals through a population of brainstem cholecystokinin neurons to mediate anorectic signalling. Elife. 2020 Jul 29;9:e55164. PMID: 32723474. PMC7410488.
Yeo CR, Agrawal M, Hoon S, Shabbir A, Shrivastava MK, Huang S, Khoo CM, Chhay V, Shabeer M, Shyong Tai E, Vidal-Puig A, Toh SA. Reply to: ‘Browning capabilities of human primary adipose-derived stromal cells compared to SGBS cells’. Sci Rep. 2020 Jun 15;10(1):9634. PMID: 32541770. PMC7295789.
Zangemeister L, Grabenhorst F, Schultz W. Neural activity in human ventromedial prefrontal cortex reflecting the intention to save reward. Soc Cogn Affect Neurosci. 2020 Jan 28. Epub ahead of print. PubMed PMID: 31993656.

2019

Adriaensses A; Gribble FM; Reimann F. The glucose-dependent insulinotropic polypeptide signalling axis in the central nervous system. Peptides. 2020 Mar;125:170194. Epub 2019 Nov 4. Review. PMID: 31697967
Adriaenssens AE, Biggs EK, Darwish T, Tadross J, Sukthankar T, Girish M, Polex-Wolf J, Lam BY, Zvetkova I, Pan W, Chiarugi D, Yeo GSH, Blouet C, Gribble FM, Reimann F. GlucoseDependent Insulinotropic Polypeptide Receptor-Expressing Cells in the Hypothalamus Regulate Food Intake. Cell Metab. 2019 Aug 19. [Epub ahead of print] PMID: 31447324.
Ahmed RM, Landin-Romero R, Liang CT, Keogh JM, Henning E, Strikwerda-Brown C, Devenney EM, Hodges JR, Kiernan MC, Farooqi IS, Piguet O. Neural networks associated with body composition in frontotemporal dementia. Ann Clin Transl Neurol. 2019 Sep;6(9):1707-1717. PMID: 31461580.
Aiken CEM, Hone L, Murphy HR, Meek CL. Improving outcomes in gestational diabetes: does gestational weight gain matter? Diabet Med. 2019 Feb;36(2):167-176. doi: 10.1111/dme.13767. PMID:29932243
Aiken CE, Tarry-Adkins JL, Ashmore TJ, Ozanne SE. Early life environment influences the trajectory of post-partum weight loss in adult female rats. Reprod Biomed Online. 2019 May;38(5):779-786. doi: 10.1016/j.rbmo.2018.12.002. Epub 2018 Dec 12. PMID: 30885667. PMCID: PMC6491499
Aiken CE, Tarry-Adkins JL, Ozanne SE. Assaying Reproductive Capacity in Female Rodents. Methods Mol Biol.
2019;1916:157-166. doi: 10.1007/978-1-4939-8994-2_15. PMID: 30535693
Aiken CE, Tarry-Adkins JL, Spiroski AM, Nuzzo AM, Ashmore TJ, Rolfo A, Sutherland MJ, Camm EJ, Giussani DA, Ozanne SE. Chronic fetal hypoxia disrupts the peri-conceptual environment in nextgeneration adult female rats. J Physiol. 2019 May;597(9):2391-2401. doi: 10.1113/JP277431. Epub 2019 Mar 24. PMID: 30791124 PMCID: PMC6487938
Aiken CE, Tarry-Adkins JL, Spiroski AM, Nuzzo AM, Ashmore TJ, Rolfo A, Sutherland MJ, Camm EJ, Giussani DA, Ozanne SE. Chronic gestational hypoxia accelerates ovarian aging and lowers ovarian reserve in next-generation adult rats. FASEB J. 2019 Jun;33(6):7758-7766. doi: 10.1096/fj.201802772R. Epub 2019 Mar 19. PMID: 30888848 PMCID: PMC6529349
Ajjaji D, Ben M’barek K, Mimmack ML, England C, Herscovitz H, Dong L, Kay RG, Patel S, Saudek V, Small DM, Savage DB, Thiam AR. Dual binding motifs underpin the hierarchical association of perilipins1 -3 with lipid droplets. Mol Biol Cell. 2019 Mar 1;30(5):703-716. doi: 10.1091/mbc.E18-08-0534. Epub 2019 Jan 16. PMID: 30649995 PMCID: PMC6589688
Al-Massadi O, Quiñones M, Clasadonte J, Hernandez-Bautista R, Romero-Picó A, Folgueira C, Morgan DA, Kalló I, Heras V, Senra A, Funderburk SC, Krashes MJ, Souto Y, Fidalgo M, Luquet S, Chee MJ, Imbernon M, Beiroa D, García-Caballero L, Gallego R, Lam BYH, Yeo G, Lopez M, Liposits Z, Rahmouni K, Prevot V, Dieguez C, Nogueiras R. MCH Regulates SIRT1/FoxO1 and Reduces POMC Neuronal Activity to Induce Hyperphagia, Adiposity, and Glucose Intolerance. Diabetes. 2019 Dec;68(12):2210-2222. Epub 2019 Sep 16. PubMed PMID:31530579; PubMed Central PMCID: PMC6868473.
Araiz C, Yan A, Bettedi L, Samuelson I, Virtue S, McGavigan AK, Dani C, Vidal-Puig A, Foukas LC. Enhanced β-adrenergic signalling underlies an age-dependent beneficial metabolic effect of PI3K p110α inactivation in adipose tissue. Nat Commun. 2019 Apr 4;10(1):1546. PMID:30948720
Ast J, Arvaniti A, Fine NHF, Nasteska D, Ashford FB, Stamataki Z, Koszegi Z, Bacon A, Jones BJ, Lucey MA, Sasaki S, Brierley DI, Hastoy B, Tomas A, D’Agostino G, Reimann F, Lynn FC, Reissaus CA, Linnemann AK, D’Este E, Calebiro D, Trapp S, Johnsson K, Podewin T, Broichhagen J, Hodson DJ. Super-resolution microscopy compatible fluorescent probes reveal endogenous glucagon-like peptide-1 receptor distribution and dynamics. Nat Commun. 2020 Jan 24;11 (1):467. PubMed PMID: 31980626; PubMed Central PMCID: PMC6981144.
Badenes M, Amin A, González-García I, Félix I, Burbridge E, Cavadas M, Ortega FJ, de Carvalho É, Faísca P, Carobbio S, Seixas E, Pedroso D, Neves-Costa A, Moita LF, Fernández-Real JM, Vidal-Puig A, Domingos A, López M, Adrain C. Deletion of iRhom2 protects against dietinduced obesity by increasing thermogenesis. Mol Metab. 2020 Jan;31:67-84.Epub 2019 Oct 31. PubMed PMID: 31918923; PubMed Central PMCID: PMC6909339.
Baig S, Parvaresh Rizi E, Chia C, Shabeer M, Aung N, Loh TP, Magkos F, Vidal-Puig A, Seet RCS, Khoo CM, Toh SA. Genes Involved in Oxidative Stress Pathways Are Differentially Expressed in Circulating Mononuclear Cells Derived From Obese Insulin-Resistant and Lean Insulin-Sensitive Individuals Following a Single Mixed-Meal Challenge. Front Endocrinol (Lausanne). 2019 Apr 24;10:256. eCollection 2019. PMID:31068904 PubMed Central PMCID:PMC6491694
Bally L, Gubler P, Thabit H, Hartnell S, Ruan Y, Wilinska ME, Evans ML, Semmo M, Vogt B, Coll AP, Stettler C, Hovorka R. Fully closed-loop insulin delivery improves glucose control of inpatients with type 2 diabetes receiving hemodialysis. Kidney Int. 2019 Sep;96(3):593-596. PMID: 31133457.
Bally L, Herzig D, Ruan Y, Wilinska ME, Semmo M, Vogt A, Wertli MM, Vogt B, Stettler C, Hovorka R. Short-term fully closed-loop insulin delivery using faster insulin aspart compared with standard insulin aspart in type 2 diabetes. Diabetes Obes Metab. 2019 Aug 28. [Epub ahead of print] PMID: 31464063.
Barbosa AD, Lim K, Mari M, Edgar JR, Gal L, Sterk P, Jenkins BJ, Koulman A, Savage DB, Schuldiner M, Reggiori F, Wigge PA, Siniossoglou S. Compartmentalized Synthesis of Triacylglycerol at the Inner Nuclear Membrane Regulates Nuclear Organization. Dev Cell. 2019 Sep 23;50(6):755-766.e6. PMID: 31422915.
Bariana TK, Labarque V, Heremans J, Thys C, De Reys M, Greene D, Jenkins B, Grassi L, Seyres D, Burden F, Whitehorn D, Shamardina O, Papadia S, Gomez K, BioResource N, Van Geet C, Koulman A, Ouwehand WH, Ghevaert C, Frontini M, Turro E, Freson K. Sphingolipid dysregulation due to lack of functional KDSR impairs proplatelet formation causing thrombocytopenia. Haematologica. 2019 May;104(5):1036-1045. Epub 2018 Nov 22. PMID:30467204 PubMed Central PMCID:PMC6518879
Bashari WA, Senanayake R, Fernández-Pombo A, Gillett D, Koulouri O, Powlson AS, Matys T, Scoffings D, Cheow H, Mendichovszky I, Gurnell M. Modern imaging of pituitary adenomas. Best Pract Res Clin Endocrinol Metab. 2019 May 28. [Epub ahead of print] Review. PMID:31208872
Battelino T, Danne T, Bergenstal RM, Amiel SA, Beck R, Biester T, Bosi E, Buckingham BA, Cefalu WT, Close KL, Cobelli C, Dassau E, DeVries JH, Donaghue KC, Dovc K, Doyle FJ 3rd, Garg S, Grunberger G, Heller S, Heinemann L, Hirsch IB, Hovorka R, Jia W, Kordonouri O, Kovatchev B, Kowalski A, Laffel L, Levine B, Mayorov A, Mathieu C, Murphy HR, Nimri R, Nørgaard K, Parkin CG, Renard E, Rodbard D, Saboo B, Schatz D, Stoner K, Urakami T, Weinzimer SA, Phillip M. Clinical Targets for Continuous Glucose Monitoring Data Interpretation: Recommendations From the International Consensus on Time in Range. Diabetes Care. 2019 Aug;42(8):1593-1603. Epub 2019 Jun 8. Review. PMID:31177185 PubMed Central PMCID:PMC6973648
Beardsall K, Thomson L, Elleri D, Dunger DB, Hovorka R. Feasibility of automated insulin delivery guided by continuous glucose monitoring in preterm infants. Arch Dis Child Fetal Neonatal Ed. 2019 Aug 9. pii: fetalneonatal-2019-316871. [Epub ahead of print] PMID: 31399480.
Biancolin AD, Martchenko A, Mitova E, Gurges P, Michalchyshyn E, Chalmers JA, Doria A, Mychaleckyj JC, Adriaenssens AE, Reimann F, Gribble FM, Gil-Lozano M, Cox BJ, Brubaker PL. The core clock gene, Bmal1, and its downstream target, the SNARE regulatory protein secretagogin, are necessary for circadian secretion of glucagon-like peptide-1. Mol Metab. 2020 Jan;31:124-137. Epub 2019 Nov 21. PubMed PMID: 31918914; PubMed Central PMCID: PMC6920326.
Boughton CK, Bally L, Hartnell S, Wilinska M, Coll AP, Evans M, Stettler C, Hovorka R. Closedloop insulin delivery in end-of-life care: a case report. Diabet Med. 2019 Apr 19. [Epub ahead of print] PMID: 31002426.
Boughton CK, Bally L, Hovorka R. Closed-loop management of inpatient hyperglycemia. Aging (Albany NY). 2019 Aug 8;11(15):5292-5293. PMID: 31395790
Boughton CK, Bally L, Martignoni F, Hartnell S, Herzig D, Vogt A, Wertli MM, Wilinska ME, Evans ML, Coll AP, Stettler C, Hovorka R. Fully closed-loop insulin delivery in inpatients receiving nutritional support: a two-centre, open-label, randomised controlled trial. Lancet Diabetes Endocrinol. 2019 May;7(5):368-377. Epub 2019 Mar 29. PMID:30935872 PubMed Central PMCID:PMC6467839
Boughton CK, Hartnell S, Allen JM, Hovorka R. The importance of prandial insulin bolus timing with hybrid closed-loop systems. Diabet Med. 2019 Aug 23. [Epub ahead of print] PMID: 31441093.
Boughton CK, Hovorka R. Advances in artificial pancreas systems. Sci Transl Med. 2019 Mar 20;11(484):eaaw4949. doi: 10.1126/scitranslmed.aaw4949. PMID: 30894501
Broekema MF, Savage DB, Monajemi H, Kalkhoven E. Gene-gene and gene-environment interactions in lipodystrophy: Lessons learned from natural PPARγ mutants. Biochim Biophys Acta Mol Cell Biol Lipids. 2019 May;1864(5):715-732. Review. PMID: 30742913
Chiesa ST, Charakida M, McLoughlin E, Nguyen HC, Georgiopoulos G, Motran L, Elia Y, Marcovecchio ML, Dunger DB, Dalton RN, Daneman D, Sochett E, Mahmud FH, Deanfield JE. Elevated high-density lipoprotein in adolescents with Type 1 diabetes is associated with endothelial dysfunction in the presence of systemic inflammation. Eur Heart J. 2019 Nov 14;40(43):3559-3566. doi: 10.1093/eurheartj/ehz114. PMID: 30863865 PMCID: PMC6855140
Clément M, Raffort J, Lareyre F, Tsiantoulas D, Newland SA, Lu Y, Masters L, Harrison J, Saveljeva S, Ma MK, Ozsvar-Kozma M, Lam B, Yeo GS, Binder CJ, Kaser A, Mallat Z. Impaired Autophagy in CD11b(+) Dendritic Cells Expands CD4(+) Regulatory T Cells And Limits Atherosclerosis in Mice. Circ Res. 2019 Oct 15. [Epub ahead of print] PMID: 31610723.
Coll AP, Chen M, Taskar P, Rimmington D, Patel S, Tadross J, Cimino I, Tung YCL, Miedzybrodzka E, Welsh P, Virtue S, Rodriguez-Cuenca S, Yang M, Goldspink DA, Tomaz RA, Harding HP, Melvin A, Yeo GSH, Preiss D, Vidal-Puig A, Vallier L, Ron D, Gribble FM, Reimann F, Sattar N, Savage DB, Allan BB, O’Rahilly S. GDF15 and the beneficial actions of metformin in pre-diabetes. Nature. 2019 Dec 25. Epub ahead of print PMID: 31875646.
Colombo M, Valo E, McGurnaghan SJ, Sandholm N, Blackbourn LAK, Dalton RN, Dunger D, Groop PH, McKeigue PM, Forsblom C, Colhoun HM; FinnDiane Study Group and the Scottish Diabetes Research Network (SDRN) Type 1 Bioresource Collaboration. Biomarker panels associated with progression of renal disease in type 1 diabetes. Diabetologia. 2019 Jun 20. [Epub ahead of print] PMID:31222504; PubMed Central ID: PMC6677704
Cyranka M, Veprik A, McKay EJ, van Loon N, Thijsse A, Cotter L, Hare N, Saibudeen A, Lingam S, Pires E, Larraufie P, Reimann F, Gribble F, Stewart M, Bentley E, Lear P, McCullagh J, Cantley J, Cox RD, de Wet H. Abcc5 Knockout Mice Have Lower Fat Mass and Increased Levels of Circulating GLP-1. Obesity (Silver Spring). 2019 Aug;27(8):1292-1304. PMID: 31338999; PubMed Central ID: PMC6658130
Dovc K, Boughton C, Tauschmann M, Thabit H, Bally L, Allen JM, Acerini CL, Arnolds S, de Beaufort C, Bergenstal RM, Campbell F, Criego A, Dunger DB, Elleri D, Evans ML, FröhlichReiterer E, Hofer S, Kapellen T, Leelarathna L, Pieber TR, Rami-Merhar B, Shah VN, Sibayan J, Wilinska ME, Hovorka R; APCam11, AP@Home, and KidsAP Consortia. Young Children Have Higher Variability of Insulin Requirements: Observations During Hybrid Closed-Loop Insulin Delivery. Diabetes Care. 2019 Jul;42(7):1344-1347. Epub 2019 May 21. PubMed ID: 31221700; PubMed Central ID: PMC6609966
Dye FS, Larraufie P, Kay R, Darwish T, Rievaj J, Goldspink DA, Meek CL, Middleton SJ, Hardwick RH, Roberts GP, Percival-Alwyn JL, Vaughan T, Ferraro F, Challis BG, O’Rahilly S, Groves M, Gribble FM, Reimann F. Characterisation of proguanylin expressing cells in the intestine – evidence for constitutive luminal secretion. Sci Rep. 2019 Oct 30;9(1):15574. PubMed ID: 31666564; PubMed Central ID: PMC6821700.
Evans ML, Golubic R. Technology to overcome clinical inertia in insulin therapy. Lancet. 2019 Mar 16;393(10176):1078-1080. PMID: 30808513
Evans M, Welsh Z, Ells S, Seibold A. The Impact of Flash Glucose Monitoring on Glycaemic Control as Measured by HbA1c: A Meta-analysis of Clinical Trials and Real-World Observational Studies. Diabetes Ther. 2020 Jan;11(1):83-95. Epub 2019 Oct 31. PubMed PMID: 31673972; PubMed Central PMCID: PMC6965602.
Fernandez-Twinn DS, Hjort L, Novakovic B, Ozanne SE, Saffery R. Intrauterine programming of obesity and type 2 diabetes. Diabetologia. 2019 Oct;62(10):1789-1801. Review. PMID: 31451874.
Flatt AJS, Little SA, Speight J, Leelarathna L, Walkinshaw E, Tan HK, Bowes A, LubinaSolomon A, Holmes-Truscott E, Chadwick TJ, Wood R, McDonald TJ, Kerr D, Flanagan D, Brooks A, Heller SR, Evans ML, Shaw JAM. Predictors of Recurrent Severe Hypoglycemia in Adults With Type 1 Diabetes and Impaired Awareness of Hypoglycemia During the HypoCOMPaSS Study. Diabetes Care. 2019 Sep 4. [Epub ahead of print] PMID: 31484666.
Fletcher PC, Kenny PJ. Correction: Food addiction: a valid concept? Neuropsychopharmacology. 2019 Mar;44(4):834. doi: 10.1038/s41386-018-0288-1. PMID: 30532060 PMCID: PMC6372676
Flores A, Argetsinger LS, Stadler LKJ, Malaga AE, Vander PB, DeSantis LC, Joe RM, Cline JM, Keogh JM, Henning E, Barroso I, Mendes de Oliveira E, Chandrashekar G, Clutter ES, Hu Y, Stuckey J, Farooqi IS, Myers MG Jr, Carter-Su C. Crucial Role of the SH2B1 PH Domain for the Control of Energy Balance. Diabetes. 2019 Nov;68(11):2049-2062. doi: 10.2337/db19-0608. Epub 2019 Aug 22. PubMed PMID: 31439647.
Folgueira C, Beiroa D, Porteiro B, Duquenne M, Puighermanal E, Fondevila MF, BarjaFernández S, Gallego R, Hernández-Bautista R, Castelao C, Senra A, Seoane P, Gómez N, Aguiar P, Guallar D, Fidalgo M, Romero-Pico A, Adan R, Blouet C, Labandeira-García JL, Jeanrenaud F, Kallo I, Liposits Z, Salvador J, Prevot V, Dieguez C, Lopez M, Valjent E, Frühbeck G, Seoane LM, Nogueiras R. Hypothalamic dopamine signaling regulates brown fat thermogenesis. Nat Metab. 2019 Aug;1(8):811-829. doi: 10.1038/s42255-019-0099-7. Epub 2019 Aug 19. PubMed PMID: 31579887; PubMed Central PMCID: PMC6774781.
Fretts AM, Imamura F, Marklund M, Micha R, Wu JHY, Murphy RA, Chien KL, McKnight B, Tintle N, Forouhi NG, Qureshi WT, Virtanen JK, Wong K, Wood AC, Lankinen M, Rajaobelina K, Harris TB, Djoussé L, Harris B, Wareham NJ, Steffen LM, Laakso M, Veenstra J, Samieri C, Brouwer IA, Yu CI, Koulman A, Steffen BT, Helmer C, Sotoodehnia N, Siscovick D, Gudnason V; InterAct Consortium, Wagenknecht L, Voutilainen S, Tsai MY, Uusitupa M, Kalsbeek A, Berr C, Mozaffarian D, Lemaitre RN. Associations of circulating very-long-chain saturated fatty acids and incident type 2 diabetes: a pooled analysis of prospective cohort studies. Am J Clin Nutr. 2019 Apr 1;109(4):1216-1223. PubMed PMID: 30982858; PubMed Central PMCID:PMC6500926
Furse S, Billing G, Snowden SG, Smith J, Goldberg G, Koulman A. Relationship between the lipid composition of maternal plasma and infant plasma through breast milk. Metabolomics. 2019 Sep 25;15(10):129. doi: 10.1007/s11306-019-1589-z. PubMed PMID: 31555909; PubMed Central PMCID: PMC6761246.
Furse S, Koulman A. The Lipid and Glyceride Profiles of Infant Formula Differ by Manufacturer, Region and Date Sold. Nutrients. 2019 May 20;11(5). PubMed PMID:31137537; PubMed Central PMCID: PMC6567151
Furse S, Snowden SG, Olga L, Prentice P, Ong KK, Hughes IA, Acerini CL, Dunger DB, Koulman A. Evidence from 3-month-old infants shows that a combination of postnatal feeding and exposures in utero shape lipid metabolism. Sci Rep. 2019 Oct 4;9(1):14321. PubMed PMID: 31586083
Furse S, Torres AG, Koulman A. Fermentation of Milk into Yoghurt and Cheese Leads to Contrasting Lipid and Glyceride Profiles. Nutrients. 2019 Sep 11;11(9). pii: E2178. doi: 10.3390/ nu11092178. PubMed PMID: 31514309.
Furse S, White SL, Meek CL, Jenkins B, Petry CJ, Vieira MC, Ozanne SE, Dunger DB, Poston L, Koulman A. Altered triglyceride and phospholipid metabolism predates the diagnosis of gestational diabetes in obese pregnancy. Mol Omics. 2019 Dec 2;15(6):420-430. PubMed PMID: 31599289.
Gault EJ, Cole TJ, Casey S, Hindmarsh PC, Betts P, Dunger DB, Donaldson MDC. Effect of oxandrolone and timing of pubertal induction on final height in Turner syndrome: final analysis of the UK randomised placebo-controlled trial. Arch Dis Child. 2019 Dec 20. pii: archdischild-2019- 317695. Epub ahead of print. PubMed PMID: 31862699.
Giustina A, Barkan A, Beckers A, Biermasz N, Biller BMK, Boguszewski C, Bolanowski M, Bonert V, Bronstein MD, Casanueva FF, Clemmons D, Colao A, Ferone D, Fleseriu M, Frara S, Gadelha MR, Ghigo E, Gurnell M, Heaney AP, Ho K, Ioachimescu A, Katznelson L, Kelestimur F, Kopchick J, Krsek M, Lamberts S, Losa M, Luger A, Maffei P, Marazuela M, Mazziotti G, Mercado M, Mortini P, Neggers S, Pereira AM, Petersenn S, Puig-Domingo M, Salvatori R, Shimon I, Strasburger C, Tsagarakis S, van der Lely AJ, Wass J, Zatelli MC, Melmed S. A Consensus on the Diagnosis and Treatment of Acromegaly Comorbidities: An Update. J Clin Endocrinol Metab. 2019 Oct 13. [Epub ahead of print] PMID: 31606735.
Grandoch M, Flögel U, Virtue S, Maier JK, Jelenik T, Kohlmorgen C, Feldmann K, Ostendorf Y, Castañeda TR, Zhou Z, Yamaguchi Y, Nascimento EBM, Sunkari VG, Goy C, Kinzig M, Sörgel F, Bollyky PL, Schrauwen P, Al-Hasani H, Roden M, Keipert S, Vidal-Puig A, Jastroch M, Haendeler J, Fischer JW. 4-Methylumbelliferone improves the thermogenic capacity of brown adipose tissue. Nat Metab. 2019 May;1(5):546-559. PMID: 31602424.
Gribble FM, Reimann F. Function and mechanisms of enteroendocrine cells and gut hormones in metabolism. Nat Rev Endocrinol. 2019 Apr;15(4):226-237. doi: 10.1038/s41574-019-0168-8. PMID: 30760847
Groeneweg S, Peeters RP, Moran C, Stoupa A, Auriol F, Tonduti D, Dica A, Paone L, Rozenkova K, Malikova J, van der Walt A, de Coo IFM, McGowan A, Lyons G, Aarsen FK, Barca D, van Beynum IM, van der Knoop MM, Jansen J, Manshande M, Lunsing RJ, Nowak S, den Uil CA, Zillikens MC, Visser FE, Vrijmoeth P, de Wit MCY, Wolf NI, Zandstra A, Ambegaonkar G, Singh Y, de Rijke YB, Medici M, Bertini ES, Depoorter S, Lebl J, Cappa M, De Meirleir L, Krude H, Craiu D, Zibordi F, Oliver-Petit I, Polak M, Chatterjee K, Visser TJ, Visser WE. Effectiveness and safety of the tri-iodothyronine analogue Triac in children and adults with MCT8 deficiency: an international, single-arm, open-label, phase 2 trial. Lancet Diabetes Endocrinol. (2019). PMID:31377265
Grunnet LG, Pilgaard K, Alibegovic A, Jensen CB, Hjort L, Ozanne SE, Bennett M, Vaag A, Brøns C. Leukocyte telomere length is associated with elevated plasma glucose and HbA1c in young healthy men independent of birth weight. Sci Rep. 2019 May 21;9(1):7639. PMID:31113969. PMC6529491
Harshfield EL, Koulman A, Ziemek D, Marney L, Fauman EB, Paul DS, Stacey D, Rasheed A, Lee JJ, Shah N, Jabeen S, Imran A, Abbas S, Hina Z, Qamar N, Mallick NH, Yaqoob Z, Saghir T, Rizvi SNH, Memon A, Rasheed SZ, Memon FU, Qureshi IH, Ishaq M, Frossard P, Danesh J, Saleheen D, Butterworth AS, Wood AM, Griffin JL. An unbiased lipid phenotyping approach to study the genetic determinants of lipids and their association with coronary heart disease risk factors. J Proteome Res. 2019 Jun 7;18(6):2397-2410. doi: 10.1021/acs.jproteome.8b00786. Epub 2019 Apr 26. PMID: 30887811 PMCID: PMC6558644
Humphrey JA, Kanthasamy S, Coughlin P, Coll AP, Robinson AAH. Outcome of transmetatarsal amputations in patients with diabetes mellitus. Foot (Edinb). 2019 Apr 8;40:22-26. [Epub ahead of print] PMID: 31054475.
Holt, M. K., Pomeranz, L. E., Beier, K. T., Reimann, F., Gribble, F., & Rinaman, L. (2019). Synaptic Inputs to the Mouse Dorsal Vagal Complex and Its Resident Preproglucagon Neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience, 39 (49), 9767- 9781. PMID: 31666353. PMC6891065.
Jepsen SL, Grunddal KV, Wewer Albrechtsen NJ, Engelstoft MS, Gabe MBN, Jensen EP, Ørskov C, Poulsen SS, Rosenkilde MM, Pedersen J, Gribble FM, Reimann F, Deacon CF, Schwartz TW, Christ AD, Martin RE, Holst JJ. Paracrine Crosstalk between Intestinal L- and Dcells Controls Secretion of Glucagon-Like Peptide-1 in mice. Am J Physiol Endocrinol Metab. 2019 Sep 10. [Epub ahead of print] PMID: 31503512.
Jepsen SL, Vestergaard ET, Larraufie P, Gribble FM, Reimann F, Jørgensen JOL, Holst JJ, Kuhre RE. Ghrelin does not directly stimulate secretion of glucagon-like peptide-1. J Clin Endocrinol Metab. 2019 Oct 14. [Epub ahead of print] PMID: 31608930.
Jéru I, Vantyghem MC, Bismuth E, Cervera P, Barraud S; PLIN1-Study Group, Auclair M, Vatier C, Lascols O, Savage DB, Vigouroux C. Diagnostic Challenge in PLIN1-Associated Familial Partial Lipodystrophy. J Clin Endocrinol Metab. 2019 Dec 1;104(12):6025-6032. PubMed PMID: 31504636; PubMed Central PMCID: PMC6916795.
Johann K, Cremer AL, Fischer AW, Heine M, Pensado ER, Resch J, Nock S, Virtue S, Harder L, Oelkrug R, Astiz M, Brabant G, Warner A, Vidal-Puig A, Oster H, Boelen A, López M, Heeren J, Dalley JW, Backes H, Mittag J. Thyroid-Hormone-Induced Browning of White Adipose Tissue Does Not Contribute to Thermogenesis and Glucose Consumption. Cell Rep. 2019 Jun 11;27 (11):3385-3400.e3. PMID: 31189119.
Joustra SD, Roelfsema F, van Trotsenburg ASP, Schneider HJ, Kosilek RP, Kroon HM, Logan JG, Butterfield NC, Zhou X, Toufaily C, Bak B, Turgeon MO, Brûlé E, Steyn FJ, Gurnell M, Koulouri O, Le Tissier P, Fontanaud P, Duncan Bassett JH, Williams GR, Oostdijk W, Wit JM, Pereira AM, Biermasz NR, Bernard DJ, Schoenmakers N. IGSF1 Deficiency Results in Human and Murine Somatotrope Neurosecretory Hyperfunction. J Clin Endocrinol Metab. 2019 Oct 25. [Epub ahead of print] PMID: 31650157.
Karasik D, [5 authors], Barroso I, [148 authors], Ohlsson C. Disentangling the genetics of lean mass. Am J Clin Nutr. 2019 Feb 1;109(2):276-287. PMID: 30721968 PMCID: PMC6500901
Koulman A, Furse S, Baumert M, Goldberg G, Bluck L. Rapid profiling of triglycerides in human breast milk using liquid extraction surface analysis Fourier transform mass spectrometry reveals new very long chain fatty acids and differences within individuals. Rapid Commun Mass Spectrom. 2019 Aug 15;33(15):1267-1276. PMID:31009547; PubMed Central PMCID:PMC6772081
Kosīte D, König LM, De-Loyde K, Lee I, Pechey E, Clarke N, Maynard O, Morris RW, Munafò MR, Marteau TM, Fletcher PC, Hollands GJ. Plate size and food consumption: a pre-registered experimental study in a general population sample. Int J Behav Nutr Phys Act. 2019 Aug 28;16 (1):75. PMID: 31462252.
Kuhre RE, Ghiasi SM, Adriaenssens AE, Wewer Albrechtsen NJ, Andersen DB, Aivazidis A, Chen L, Mandrup-Poulsen T, Ørskov C, Gribble FM, Reimann F, Wierup N, Tyrberg B, Holst JJ. No direct effect of SGLT2 activity on glucagon secretion. Diabetologia. 2019 Jun;62 (6):1011-1023. 2019 Mar 22. PMID:30903205; PMCID: PMC7212061
Kuijper B, Hanson MA, Vitikainen EIK, Marshall HH, Ozanne SE, Cant MA. Developing differences: early-life effects and evolutionary medicine. Philos Trans R Soc Lond B Biol Sci. 2019 Apr 15;374(1770):20190039. PMID:30966882; PMCID:PMC6460072
Larraufie P, Roberts GP, McGavigan AK, Kay RG, Li J, Leiter A, Melvin A, Biggs EK, Ravn P, Davy K, Hornigold DC, Yeo GSH, Hardwick RH, Reimann F, Gribble FM. Important Role of the GLP-1 Axis for Glucose Homeostasis after Bariatric Surgery. Cell Rep. 2019 Feb 5;26(6):1399-1408.e6. PMID: 30726726 PMCID: PMC6367566
Lawton J, Blackburn M, Rankin D, Allen JM, Campbell FM, Leelarathna L, Tauschmann M, Thabit H, Wilinska ME, Elleri D, Hovorka R. Participants’ Experiences of, and Views About, Daytime Use of a Day-and -Night Hybrid Closed-Loop System in Real Life Settings: Longitudinal Qualitative Study. Diabetes Technol Ther. 2019 Mar;21(3):119-127. doi: 10.1089/dia.2018.0306. Epub 2019 Feb 5. PMID: 30720338 PMCID: PMC6434584
Lee E, Miedzybrodzka EL, Zhang X, Hatano R, Miyamoto J, Kimura I, Fujimoto K, Uematsu S, Rodriguez-Cuenca S, Vidal-Puig A, Gribble FM, Reimann F, Miki T. Diet-Induced Obese Mice and Leptin-Deficient Lepob/ob Mice Exhibit Increased Circulating GIP Levels Produced by Different Mechanisms. Int J Mol Sci. 2019 Sep 10;20(18). PMID: 31509948.
Leelarathna L, Beck RW, Bergenstal RM, Thabit H, Hovorka R; APCam11, AP@home04, and APCam08 Investigators. Glucose Management Indicator (GMI): Insights and Validation Using Guardian 3 and Navigator 2 Sensor Data. Diabetes Care. 2019 Apr;42(4):e60-e61. doi: 10.2337/dc18-2479. Epub 2019 Feb 6. PMID: 30728221
Lippincott MF, León S, Chan YM, Fergani C, Talbi R, Farooqi IS, Jones CM, Arlt W, Stewart SE, Cole TR, Terasawa E, Hall JE, Shaw ND, Navarro VM, Seminara SB. Hypothalamic Reproductive Endocrine Pulse Generator Activity Independent of Neurokinin B and Dynorphin Signaling. J Clin Endocrinol Metab. 2019 May 27. [Epub ahead of print]. PMID:31132118; PMCID:PMC6736049
López-Tello J, Pérez-García V, Khaira J, Kusinski LC, Cooper WN, Andreani A, Grant I, Fernández de Liger E, Lam BY, Hemberger M, Sandovici I, Constancia M, Sferruzzi-Perri AN. Fetal and trophoblast PI3K p110α have distinct roles in regulating resource supply to the growing fetus in mice. Elife. 2019 Jun 26;8. PMID:31241463; PMCID: PMC6634971
Lotta LA, Mokrosiński J, Mendes de Oliveira E, Li C, Sharp SJ, Luan J, Brouwers B, Ayinampudi V, Bowker N, Kerrison N, Kaimakis V, Hoult D, Stewart ID, Wheeler E, Day FR, Perry JRB, Langenberg C, Wareham NJ, Farooqi IS. Human Gain-of-Function MC4R Variants Show Signaling Bias and Protect against Obesity. Cell. 2019 Apr 18;177(3):597-607.e9. PMID:31002796; PMCID: PMC6476272
Lu VB, Rievaj J, O’Flaherty EA, Smith CA, Pais R, Pattison LA, Tolhurst G, Leiter AB, Bulmer DC, Gribble FM, Reimann F. Adenosine triphosphate is co-secreted with glucagon-like peptide-1 to modulate intestinal enterocytes and afferent neurons. Nat Commun. 2019 Mar 4;10(1):1029. doi: 10.1038/s41467-019-09045-9. PMID: 30833673 PMCID: PMC6399286
Macaulay S, Buchmann EJ, Dunger DB, Norris SA. Reliability and validity of last menstrual period for gestational age estimation in a low-to-middle-income setting. J Obstet Gynaecol Res. 2019 Jan;45(1):217-225. doi: 10.1111/jog.13801. Epub 2018 Sep 6. PMID: 30191629
Maniero C, Scudieri P, Haris Shaikh L, Zhao W, Gurnell M, Galietta LJV, Brown MJ. ANO4 (Anoctamin 4) Is a Novel Marker of Zona Glomerulosa That Regulates Stimulated Aldosterone Secretion. Hypertension. 2019 Nov;74(5):1152-1159. PMID: 31564164.
Mann JP, Savage DB. What lipodystrophies teach us about the metabolic syndrome. J Clin Invest. 2019 Aug 5;130:4009-4021. Review. PMID: 31380809.
Marcovecchio ML, Dalton RN, Daneman D, Deanfield J, Jones TW, Neil HAW, Dunger DB; Adolescent type 1 Diabetes cardio-renal Intervention Trial (AdDIT) study group. A new strategy for vascular complications in young people with type 1 diabetes mellitus. Nat Rev Endocrinol. 2019 Jul;15(7):429-435. Review. PMID:30996294
Mazarello Paes V, Barrett JK, Taylor-Robinson DC, Chesters H, Charalampopoulos D, Dunger DB, Viner RM, Stephenson TJ. Effect of early glycemic control on HbA1c tracking and development of vascular complications after 5 years of childhood onset type 1 diabetes: Systematic review and meta -analysis. Pediatr Diabetes. 2019 Aug;20(5):494-509. Epub 2019 Apr 24. Review. PMID:30932298; PMCID:PMC6701989
Medic N, Kochunov P, Ziauddeen H, Ersche KD, Nathan PJ, Ronan L, Fletcher PC. BMI-related cortical morphometry changes are associated with altered white matter structure. Int J Obes (Lond). 2019 Mar;43(3):523-532. PMID: 30568264 PMCID: PMC6462878
Melvin A, Lacerda E, Dockrell S M, O’Rahilly S, Nacul L. Circulating levels of GDF15 in patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. J Transl Med. 2019 Dec 4;17 (1):409. PMID: 31801546. PMCID: PMC6892232
Melvin A, Stears A, Savage DB. Recent developments in lipodystrophy. Curr Opin Lipidol. 2019 Aug;30(4):284-290. PMID: 31135595.
Menting MD, Mintjens S, van de Beek C, Frick CJ, Ozanne SE, Limpens J, Roseboom TJ, Hooijmans CR, van Deutekom AW, Painter RC. Maternal obesity in pregnancy impacts offspring cardiometabolic health: Systematic review and meta-analysis of animal studies. Obes Rev. 2019 May;20(5):675-685. doi: 10.1111/obr.12817. PMID: 30633422 PMCID: PMC6849816
Menzies-Gow A, Corren J, Bel EH, Maspero J, Heaney LG, Gurnell M, Wessman P, Martin UJ, Siddiqui S, Garcia Gil E. Corticosteroid tapering with benralizumab treatment for eosinophilic asthma: PONENTE Trial. ERJ Open Res. 2019 Sep 25;5(3). PMID: 31579676.
Müller TD, Finan B, Bloom SR, D’Alessio D, Drucker DJ, Flatt PR, Fritsche A, Gribble F, Grill HJ, Habener JF, Holst JJ, Langhans W, Meier JJ, Nauck MA, Perez-Tilve D, Pocai A, Reimann F, Sandoval DA, Schwartz TW, Seeley RJ, Stemmer K, Tang-Christensen M, Woods SC, DiMarchi RD, Tschöp MH. Glucagon-like peptide 1 (GLP-1). Mol Metab. 2019 Dec;30:72-130. Epub 2019 Sep 30. Review. PMID: 31767182. PMCID: PMC6812410.
Musial B, Fernandez-Twinn DS, Duque-Guimaraes D, Carr SK, Fowden AL, Ozanne SE, Sferruzzi-Perri AN. Exercise alters the molecular pathways of insulin signaling and lipid handling in maternal tissues of obese pregnant mice. Physiol Rep. 2019 Aug;7(16). PMID: 31466137.
Musolino G, Allen JM, Hartnell S, Wilinska ME, Tauschmann M, Boughton C, Campbell F, Denvir L, Trevelyan N, Wadwa P, DiMeglio L, Buckingham BA, Weinzimer S, Acerini CL, Hood K, Fox S, Kollman C, Sibayan J, Borgman S, Cheng P, Hovorka R. Assessing the efficacy, safety and utility of 6-month day-and-night automated closed-loop insulin delivery under free-living conditions compared with insulin pump therapy in children and adolescents with type 1 diabetes: an open-label, multicentre, multinational, single-period, randomised, parallel group study protocol. BMJ Open. 2019 Jun 3;9(6):e027856. PMID:31164368; PMCID: PMC6561428
Musolino G, Dovc K, Boughton CK, Tauschmann M, Allen JM, Nagl K, Fritsch M, Yong J, Metcalfe E, Schaeffer D, Fichelle M, Schierloh U, Thiele AG, Abt D, Kojzar H, Mader JK, Slegtenhorst S, Ashcroft N, Wilinska ME, Sibayan J, Cohen N, Kollman C, Hofer SE, Fröhlich -Reiterer E, Kapellen TM, Acerini CL, de Beaufort C, Campbell F, Rami-Merhar B, Hovorka R; Kidsap Consortium. Reduced burden of diabetes and improved quality of life: Experiences from unrestricted day-and-night hybrid closed-loop use in very young children with type 1 diabetes. Pediatr Diabetes. 2019 May 29. [Epub ahead of print] PMID:31140654; PMCID:PMC6771658
Nicholas LM, Ozanne SE. Early life programming in mice by maternal overnutrition: mechanistic insights and interventional approaches. Philos Trans R Soc Lond B Biol Sci. 2019 Apr 15;374(1770):20180116. PMID:30966886; PMCID:PMC6460073
Nyimanu D, Kay RG, Sulentic P, Kuc RE, Ambery P, Jermutus L, Reimann F, Gribble FM, Cheriyan J, Maguire JJ, Davenport AP. Development and validation of an LC-MS/MS method for detection and quantification of in vivo derived metabolites of [Pyr(1)]apelin-13 in humans. Sci Rep. 2019 Dec 27;9(1):19934. PubMed PMID: 31882594; PubMed Central PMCID:PMC6934825.
Oral EA, Gorden P, Cochran E, Araújo-Vilar D, Savage DB, Long A, Fine G, Salinardi T, Brown RJ. Long -term effectiveness and safety of metreleptin in the treatment of patients with partial lipodystrophy. Endocrine. 2019 Jun;64(3):500-511. doi: 10.1007/s12020-019-01862-8. PMID: 30805888 PMCID: PMC7340120
Ortega FJ, Moreno-Navarrete JM, Mercader JM, Gómez-Serrano M, García-Santos E, Latorre J, Lluch A, Sabater M, Caballano-Infantes E, Guzmán R, Macías-González M, Buxo M, Gironés J, Vilallonga R, Naon D, Botas P, Delgado E, Corella D, Burcelin R, Frühbeck G, Ricart W, Simó R, Castrillon-Rodríguez I, Tinahones FJ, Bosch F, Vidal-Puig A, Malagón MM, Peral B, Zorzano A, Fernández-Real JM. Cytoskeletal transgelin 2 contributes to gender-dependent adipose tissue expandability and immune function. FASEB J. 2019 Aug;33(8):9656-9671. PMID: 31145872.
O’Shea PM, O’Donoghue D, Bashari W, Senanayake R, Joyce MB, Powlson AS, Browne D, O’Sullivan GJ, Cheow H, Mendichovszky I, Quill D, Lowery A, Lappin D, Gurnell M, Dennedy MC. 11 C-Metomidate PET/CT is a useful adjunct for lateralization of primary aldosteronism in routine clinical practice. Clin Endocrinol (Oxf). 2019 May;90(5):670-679. doi: 10.1111/cen.13942. Epub 2019 Mar 18. PMID: 30721535
Parkinson JRC, Emsley R, Adkins JLT, Longford N, Ozanne SE, Holmes E, Modi N. Clinical and molecular evidence of accelerated ageing following very preterm birth. Pediatr Res. 2019 Dec 7. Epub ahead of print. PMID: 31812156.
Patel S, Alvarez-Guaita A, Melvin A, Rimmington D, Dattilo A, Miedzybrodzka EL, Cimino I, Maurin AC, Roberts GP, Meek CL, Virtue S, Sparks LM, Parsons SA, Redman LM, Bray GA, Liou AP, Woods RM, Parry SA, Jeppesen PB, Kolnes AJ, Harding HP, Ron D, Vidal-Puig A, Reimann F, Gribble FM, Hulston CJ, Farooqi IS, Fafournoux P, Smith SR, Jensen J, Breen D, Wu Z, Zhang BB, Coll AP, Savage DB, O’Rahilly S. GDF15 Provides an Endocrine Signal of Nutritional Stress in Mice and Humans. Cell Metab. 2019 Mar 5;29(3):707-718.e8. PMID: 30639358 PMCID: PMC6408327
Patel V, Bidault G, Chambers JE, Carobbio S, Everden AJT, Garcés C, Dalton LE, Gribble FM, VidalPuig A, Marciniak SJ. Inactivation of Ppp1r15a minimises weight gain and insulin resistance during caloric excess in female mice. Sci Rep. 2019 Feb 27;9(1):2903. doi: 10.1038/s41598-019-39562-y. PMID: 30814564 PMCID: PMC6393541
Peters C, Nicholas AK, Schoenmakers E, Lyons G, Langham S, Serra EG, Sebire NJ, Muzza M, Fugazzola L, Schoenmakers N. DUOX2/DUOXA2 Mutations Frequently Cause Congenital Hypothyroidism that Evades Detection on Newborn Screening in the United Kingdom. Thyroid. 2019 Jun;29(6):790-801. PMID:31044655; PMCID:PMC6588112
Petkevicius K, Virtue S, Bidault G, Jenkins B, Çubuk C, Morgantini C, Aouadi M, Dopazo J, Serlie MJ, Koulman A, Vidal-Puig A. Accelerated phosphatidylcholine turnover in macrophages promotes adipose tissue inflammation in obesity. Elife. 2019 Aug 16;8. PMID: 31418690.
Petry CJ, Ong KK, Hughes IA, Acerini CL, Dunger DB. Age at Menarche and Blood Pressure in Pregnancy. Pregnancy Hypertens. 2019 Jan;15:134-140. PMID: 30713829 PMCID: PMC6352955
Prats-Puig A, Xargay-Torrent S, Carreras-Badosa G, Mas-Parés B, Bassols J, Petry CJ, Girardot M, D E Zegher F, Ibáñez L, Dunger DB, Feil R, López-Bermejo A. Methylation of the C19MC microRNA locus in the placenta: association with maternal and chilhood body size. Int J Obes (Lond). 2019 Sep 25. [Epub ahead of print] PMID: 31554916.
Prentice PM, Olga L, Petry CJ, Simmons D, Murphy HR, Hughes IA, Acerini CL, Ong KK, Dunger DB. Reduced size at birth and persisting reductions in adiposity in recent, compared with earlier, cohorts of infants born to mothers with gestational diabetes mellitus. Diabetologia. 2019 Nov;62(11):1977-1987. Epub 2019 Aug 9. PubMed PMID: 31396660; PubMed Central PMCID: 6805804.
Prentice PM, Schoemaker MH, Vervoort J, Hettinga K, Lambers TT, van Tol EAF, Acerini CL, Olga L, Petry CJ, Hughes IA, Koulman A, Ong KK, Dunger DB. Human Milk Short-Chain Fatty Acid Composition is Associated with Adiposity Outcomes in Infants. J Nutr. 2019 May 1;149(5):716-722. PMID:31050748
Rana BMJ, Jou E, Barlow JL, Rodriguez-Rodriguez N, Walker JA, Knox C, Jolin HE, Hardman CS, Sivasubramaniam M, Szeto A, Cohen ES, Scott IC, Sleeman MA, Chidomere CI, Cruz Migoni S, Caamano J, Jorgensen HF, Carobbio S, Vidal-Puig A, McKenzie ANJ. A stromal cell niche sustains ILC2-mediated type-2 conditioning in adipose tissue. J Exp Med. 2019 Sep 2;216 (9):1999-2009. PMID: 31248899.
Razolli D, de Araújo T, Sant’Ana M, Kirwan P, Cintra D, Merkle F, Velloso L. POMC processing in the hypothalamus is directly regulated by saturated fat – implications for the development of obesity. Neuroendocrinology. 2019 May 20. [Epub ahead of print]. PMID: 31104058
Reimann F; Diakogiannaki E; Moss C E; Gribble F M. Cellular mechanisms governing Glucosedependent insulinotropic polypeptide secretion. Peptides. 2020 Mar;125:170206 170206. Epub 2019 Nov 19. Review. PubMed PMID: 31756367.
Riveros-McKay F, Mistry V, Bounds R, Hendricks A, Keogh JM, Thomas H, Henning E, Corbin LJ; Understanding Society Scientific Group, O’Rahilly S, Zeggini E, Wheeler E, Barroso I, Farooqi IS. Genetic architecture of human thinness compared to severe obesity. PLoS Genet. 2019 Jan 24;15(1):e1007603. PMID: 30677029 PMCID: PMC6345421
Roberts GP, Larraufie P, Richards P, Kay RG, Galvin SG, Miedzybrodzka EL, Leiter A, Li HJ, Glass LL, Ma MKL, Lam B, Yeo GSH, Scharfmann R, Chiarugi D, Hardwick RH, Reimann F, Gribble FM. Comparison of Human and Murine Enteroendocrine Cells by Transcriptomic and Peptidomic Profiling. Diabetes. 2019 May;68(5):1062-1072. doi: 10.2337/db18-0883. Epub 2019 Feb 7. PMID: 30733330 PMCID: PMC6477899
Ronan L, Alexander-Bloch A, Fletcher PC. Childhood Obesity, Cortical Structure, and Executive Function in Healthy Children. Cereb Cortex. 2019 Oct 24. [Epub ahead of print] PMID: 31646343.
Ruan Y, Willemsen RH, Wilinska ME, Tauschmann M, Dunger DB, Hovorka R. Mixed-meal tolerance test to assess residual beta-cell secretion: Beyond the area-under-curve of plasma C-peptide concentration. Pediatr Diabetes. 2019 May;20(3):282-285. doi: 10.1111/pedi.12816. PMID: 30652426 PMCID: PMC6487945
Savage DB, Watson L, Carr K, Adams C, Brage S, Chatterjee KK, Hodson L, Boesch C, Kemp GJ, Sleigh A. Accumulation of saturated intramyocellular lipid is associated with insulin resistance. J. Lipid Res. (2019) Jul;60(7):1323-1332. Epub 2019 May 2. PMID:31048405; PMCID:PMC6602127
Sefton C, Davies A, Allen TJ, Wray JR, Shoop R, Adamson A, Humphreys N, Coll AP, White A, Harno E. The metabolic abnormalities of chronic high dose glucocorticoids are not mediated by hypothalamic AgRP in male mice. Endocrinology. 2019 May 1;160(5):964-978. doi: 10.1210/en.2019-00018. PMID: 30794724 PMCID: PMC6444294
Schierloh U, Wilinska ME, Pit-Ten Cate IM, Baumann P, Hovorka R, De Beaufort C; Spidiman Study Group: Single Port Insulin Infusion for Improved Diabetes Management. Lower plasma insulin levels during overnight closed-loop in school children with type 1 diabetes: Potential advantage? A randomized cross-over trial. PLoS One. 2019 Mar 8;14(3):e0212013. doi: 10.1371/journal.pone.0212013. eCollection 2019. PMID: 30849076 PMCID: PMC6408001
Speight J, Holmes-Truscott E, Little SA, Leelarathna L, Walkinshaw E, Tan HK, Bowes A, Kerr D, Flanagan D, Heller SR, Evans ML, Shaw JAM. Satisfaction with the Use of Different Technologies for Insulin Delivery and Glucose Monitoring Among Adults with Long-Standing Type 1 Diabetes and Problematic Hypoglycemia: 2-Year Follow-Up in the HypoCOMPaSS Randomized Clinical Trial. Diabetes Technol Ther. 2019 Nov;21(11):619-626. PMID: 31335201.
Sutherland MJ, Camm EJ, Giussani DA, Ozanne SE. Chronic gestational hypoxia accelerates ovarian aging and lowers ovarian reserve in next-generation adult rats. FASEB J. 2019 Jun;33 (6):7758-7766. Epub 2019 Mar 19. PMID:30888848; PMCID:PMC6529349
Tarry-Adkins JL, Aiken CE, Ozanne SE. Neonatal, infant, and childhood growth following metformin versus insulin treatment for gestational diabetes: A systematic review and meta-analysis. PLoS Med. 2019 Aug 6;16(8):e1002848. PMID: 31386659.
Tarry-Adkins JL, Ozanne SE. Poor Early Growth and Age-Associated Disease. Subcell Biochem. 2019;91:1-19. PMID: 30888647
Tauschmann M, Allen JM, Nagl K, Fritsch M, Yong J, Metcalfe E, Schaeffer D, Fichelle M, Schierloh U, Thiele AG, Abt D, Kojzar H, Mader JK, Slegtenhorst S, Barber N, Wilinska ME, Boughton C, Musolino G, Sibayan J, Cohen N, Kollman C, Hofer SE, Fröhlich-Reiterer E, Kapellen TM, Acerini CL, de Beaufort C, Campbell F, Rami-Merhar B, Hovorka R; KidsAP Consortium. Home Use of Day-and-Night Hybrid Closed-Loop Insulin Delivery in Very Young Children: A Multicenter, 3-Week, Randomized Trial. Diabetes Care. 2019 Apr;42(4):594-600. doi: 10.2337/dc18-1881. Epub 2019 Jan 28. PMID: 30692242
Teulings NEWD, Masconi KL, Ozanne SE, Aiken CE, Wood AM. Effect of interpregnancy weight change on perinatal outcomes: systematic review and meta-analysis. BMC Pregnancy Childbirth. 2019 Oct 28;19(1):386. PMID: 31660893.
Thakar R, Gajewska-Knapik G, Ogilvy-Stuart AL, Chatterjee K, Moran C. Response to Letter to the Editor: “Alemtuzumab-induced thyroid dysfunction exhibits distinctive clinical and immunological features”. J.Clin. Endocrinol. Metab. (2019). PMID:30977836
Tschaikner M, Powell K, Jungklaus M, Fritz M, Ellmerer M, Hovorka R, Lane S, Pieber TR, Regittnig W. Novel Single-Site Device for Conjoined Glucose Sensing and Insulin Infusion: Performance Evaluation in Diabetes Patients During Home-Use. IEEE Trans Biomed Eng. 2019 Jun 27. [Epub ahead of print]. PMID:31251175
Turcot V, 39 authors, Barroso I, 65 authors, Farooqi IS, 293 authors, Loos RJF. Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity. Nat Genet. 2019 Jul;51(7):1191- 1192. PMID:31160809
van der Klaauw AA, Croizier S, Mendes de Oliveira E, Stadler LKJ, Park S, Kong Y, Banton MC, Tandon P, Hendricks AE, Keogh JM, Riley SE, Papadia S, Henning E, Bounds R, Bochukova EG, Mistry V, O’Rahilly S, Simerly RB; INTERVAL; UK10K Consortium, Minchin JEN, Barroso I, Jones EY, Bouret SG, Farooqi IS. Human Semaphorin 3 Variants Link Melanocortin Circuit Development and Energy Balance. Cell. 2019 Feb 7;176(4):729-742.e18. PMID: 30661757 PMCID: PMC6370916
Vargas-Castillo A, Tobon-Cornejo S, Del Valle-Mondragon L, Torre-Villalvazo I, SchcolnikCabrera A, Guevara-Cruz M, Pichardo-Ontiveros E, Fuentes-Romero R,Bader M, Alenina N, Vidal-Puig A, Hong E, Torres N, Tovar AR. Angiotensin-(1-7) induces beige fat thermogenesis through the Mas receptor. Metabolism. 2019 Dec 13;103:154048. Epub ahead of print. PubMed PMID: 31843339. PMCID: PMC7054746.
Vasiljevic M, Fuller G, Pilling M, Hollands GJ, Pechey R, Jebb SA, Marteau TM. What is the impact of increasing the prominence of calorie labelling? A stepped wedge randomised controlled pilot trial in worksite cafeterias. Appetite. 2019 Oct 1;141:104304. Epub 2019 May 29. PMID:31152762
Vergari E, Knudsen JG, Ramracheya R, Salehi A, Zhang Q, Adam J, Asterholm IW, Benrick A, Briant LJB, Chibalina MV, Gribble FM, Hamilton A, Hastoy B, Reimann F, Rorsman NJG, Spiliotis II, Tarasov A, Wu Y, Ashcroft FM, Rorsman P. Insulin inhibits glucagon release by SGLT2-induced stimulation of somatostatin secretion. Nat Commun. 2019 Jan 11;10(1):139. PMID: 30635569 PMCID: PMC6329806
Vestergaard ET, Hjelholt AJ, Kuhre RE, Møller N, Larraufie P, Gribble FM, Reimann F, Jessen N, Holst JJ, Jørgensen JOL. Acipimox Acutely Increases GLP-1 Concentrations in Overweight Subjects and Hypopituitary Patients. J Clin Endocrinol Metab. 2019 Jul 1;104(7):2581- 2592. PMID:30726969; PMCID:PMC7212086
Wallenius V, Elias E, Elebring E, et al. Suppression of enteroendocrine cell glucagon-like peptide (GLP)-1 release by fat-induced small intestinal ketogenesis: a mechanism targeted by Roux-enY gastric bypass surgery but not by preoperative very-low-calorie diet. Gut Published Online First: 21 November 2019. doi: 10.1136/gutjnl-2019-319372. PMID: 31753852.
Watson LPE, Carr KS, Venables MC, Acerini CL, Lyons G, Moran C, Murgatroyd PR, Chatterjee K. Quantifying energy expenditure in childhood: utility in managing pediatric metabolic disorders. Am J Clin Nutr. 2019 Nov 1;110(5):1186-1191. PMID: 31410443. PMCID: PMC6821543.
Wejaphikul K, Groeneweg S, Hilhorst-Hofstee Y, Chatterjee VK, Peeters RP, Meima ME, Visser WE. Insight into molecular determinants of T3 vs. T4 recognition from mutations in thyroid hormone receptor alpha and beta. J.Clin. Endocrinol. Metab. (2019). PMID:30817817; PMCID:PMC6599431
Westwater ML, Vilar-López R, Ziauddeen H, Verdejo-García A, Fletcher PC. Combined effects of age and BMI are related to altered cortical thickness in adolescence and adulthood. Dev Cogn Neurosci. 2019 Dec;40:100728. Epub 2019 Nov 5. PubMed PMID: 31751856; PubMed Central PMCID: PMC6913515.
Wieczorek A, Perani CV, Nixon M, Constancia M, Sandovici I, Zazara DE, Leone G, Zhang MZ, Arck PC, Solano ME. Sex-specific regulation of stress-induced fetal glucocorticoid surge by the mouse placenta. Am J Physiol Endocrinol Metab. 2019 Jul 1;317(1):E109-E120. Epub 2019 Apr 16. PMID:30990748
Wray JR, Davies A, Sefton C, Allen TJ, Adamson A, Chapman P, Lam BYH, Yeo GSH, Coll AP, Harno E, White A. Global transcriptomic analysis of the arcuate nucleus following chronic glucocorticoid treatment. Mol Metab. 2019 Aug;26:5-17. PubMed PMID: 31176677.
Yang Y, van der Klaauw AA, Zhu L, Cacciottolo TM, He Y, Stadler LKJ, Wang C, Xu P, Saito K, Hinton A Jr, Yan X, Keogh JM, Henning E, Banton MC, Hendricks AE, Bochukova EG, Mistry V, Lawler KL, Liao L, Xu J, O’Rahilly S, Tong Q; UK10K Consortium, Inês Barroso, O’Malley BW, Farooqi IS, Xu Y. Steroid receptor coactivator-1 modulates the function of Pomc neurons and energy homeostasis. Nat Commun. 2019 Apr 12;10(1):1718. PMID:30979869; PMCID:PMC6461669
Yeo SH, Kyle V, Blouet C, Jones S, Colledge WH. Mapping neuronal inputs to Kiss1 neurons in the arcuate nucleus of the mouse. PLoS One. 2019 Mar 27;14(3):e0213927. eCollection 2019. PMID:30917148; PMCID:PMC6436706
Ziegler AN, Feng Q, Chidambaram S, Testai JM, Kumari E, Rothbard DE, Constancia M, Sandovici I, Cominski T, Pang K, Gao N, Wood TL, Levison SW. Insulin-like Growth Factor II: An Essential Adult Stem Cell Niche Constituent in Brain and Intestine. Stem Cell Reports. 2019 Apr 9;12(4):816-830. doi: 10.1016/j.stemcr.2019.02.011. PMID: 30905741 PMCID: PMC6450461

2018

Adriaenssens AE, Reimann F, Gribble FM.Distribution and Stimulus Secretion Coupling of En- teroendocrine Cells along the Intestinal Tract. Compr Physiol. 2018 Sep 14;8(4):1603-1638.
Aprile M, Cataldi S, Ambrosio MR, D’Esposito V, Lim K, Dietrich A, Blüher M, Savage DB, Formisano P, Ciccodicola A, Costa V. PPARγΔ5, a Naturally Occurring Dominant-Negative Splice Isoform, Impairs PPARγ Function and Adipocyte Differentiation. Cell Rep. 2018 Nov 6;25 (6):1577-1592.e6. doi: 10.1016/j.celrep.2018.10.035.PMID:30404011
Bally L, Thabit H, Hovorka R. Closed-Loop Insulin for Glycemic Control in Noncritical Care. N Engl J Med. 2018 Nov 15;379(20):1970-1971. doi: 10.1056/NEJMc1811995. No abstract availa- ble. PMID:30428293
Bauzá-Thorbrügge M, Rodríguez-Cuenca S, Vidal-Puig A, Galmés-Pascual BM, Sbert-Roig M, Gianotti M, Lladó I, Proenza AM J. GPER and ERα mediate estradiol enhancement of mitochon- drial function in inflamed adipocytes through a PKA dependent mechanism. Steroid Biochem Mol Biol. 2018 Sep 22. pii: S0960-0760(18)30068-2. PMID:30253224
Beeson JH, Blackmore HL, Carr SK, Dearden L, Duque-Guimarães DE, Kusinski LC, Pantaleão LC, Pinnock AG, Aiken CE, Giussani DA, Fernandez-Twinn DS, Ozanne SE. Maternal exercise intervention in obese pregnancy improves the cardiovascular health of the adult male offspring. Mol Metab. 2018 Oct;16:35-44. PMID: 30293577.PMCID: PMC6157615
Berends LM, Dearden L, Tung YCL, Voshol P, Fernandez-Twinn DS, Ozanne SE. Programming of central and peripheral insulin resistance by low birthweight and postnatal catch-up growth in male mice. Diabetologia. 2018 Oct;61(10):2225-2234. PMID: 30043179PMCID: PMC6133152
Billing LJ, Smith CA, Larraufie P, Goldspink DA, Galvin S, Kay RG, Howe JD, Walker R, Pruna M, Glass L, Pais R, Gribble FM, Reimann F.Co-storage and release of insulin-like peptide-5, glu- cagon-like peptide-1 and peptideYY from murine and human colonic enteroendocrine cells. Mol Metab. 2018 Oct;16:65-75. PMID: 30104166 PMCID: PMC6158034
Boughton CK, Hovorka R. Is an artificial pancreas (closed-loop system) for Type 1 diabetes ef- fective? Diabet Med. 2018 Sep 5. Review. PMID: 30183096
Chase JG, Desaive T, Bohe J, Cnop M, De Block C, Gunst J, Hovorka R, Kalfon P, Krinsley J, Renard E, Preiser JC. Improving glycemic control in critically ill patients: personalized care to mimic the endocrine pancreas. Crit Care. 2018 Aug 2;22(1):182. Review. PMID: 30071851 PMCID: PMC6091026
Church D, Cardoso L, Kay RG, Williams CL, Freudenthal B, Clarke C, Harris J, Moorthy M, Kar- ra E, Gribble FM, Reimann F, Burling K, Williams AJK, Munir A, Jones TH, Führer D, Moeller LC, Cohen M, Khoo B, Halsall D, Semple RK. Assessment and Management of Anti-Insulin Auto- antibodies in Varying Presentations of Insulin Autoimmune Syndrome. J Clin Endocrinol Metab. 2018 Oct 1;103(10):3845-3855. PMID: 30085133 PMCID: PMC6179165
Farrington C, Stewart Z, Hovorka R, Murphy HJ. Women’s Experiences of Day-and-Night Closed-Loop Insulin Delivery During Type 1 Diabetes Pregnancy. Diabetes Sci Technol. 2018 Oct 5:1932296818800065. PMID: 30288999PMCID: PMC6232744
Goldspink DA, Reimann F, Gribble FM. Models and Tools for Studying Enteroendocrine Cells. Endocrinology. 2018 Sep 14. doi: 10.1210/en.2018-00672. PMID:30239642
Harno E, Gali Ramamoorthy T, Coll AP, White A.POMC: The Physiological Power of Hormone Processing. Physiol Rev. 2018 Oct 1;98(4):2381-2430. PMID: 30156493PMCID: PMC6170974
Hendricks AE, Billups SC, Pike HNC, Farooqi IS, Zeggini E, Santorico SA, Barroso I, Dupuis J. ProxECAT: Proxy External Controls Association Test. A new case-control gene region associ- ation test using allele frequencies from public controls. PLoS Genet. 2018 Oct 16;14 (10):e1007591. PMID: 30325923PMCID: PMC6191077
Holt MK, Richards JE, Cook DR, Brierley DI, Williams DL, Reimann F, Gribble FM, Trapp S. Preproglucagon Neurons in the Nucleus of the Solitary Tract are the Main Source of Brain GLP-1, Mediate Stress-Induced Hypophagia, and Limit Unusually Large Intakes of Food. Diabe- tes. 2018 Oct 2. pii: db180729. PMID: 30279161PMCID: PMC6314470
Jenkins B, Aoun M, Feillet-Coudray C, Coudray C, Ronis M, Koulman A. The Dietary Total-Fat Content Affects the In Vivo Circulating C15:0 and C17:0 Fatty Acid Levels Independently. Nutri- ents. 2018 Nov 3;10(11). pii: E1646. doi: 10.3390/nu10111646.PMID:30400275
Kirwan P, Kay RG, Brouwers B, Herranz-Pérez V, Jura M, Larraufie P, Jerber J, Pembroke J, Bartels T, White A, Gribble FM, Reimann F, Farooqi IS, O’Rahilly S, Merkle FT. Quantitative mass spectrometry for human melanocortin peptides in vitro and in vivo suggests prominent roles for β-MSH and desacetyl α-MSH in energy homeostasis. Mol Metab. 2018 Nov;17:82-97. PMID: 30201275 PMCID: PMC6197775
Klonoff DC, Evans ML, Lane W, Kempe HP, Renard E, Hans DeVries J, Graungaard T, Hyseni A, Gondolf T, Battelino T. A randomized, multicentre trial evaluating the efficacy and safety of fast-acting insulin aspart in continuous subcutaneous insulin infusion in adults with type 1 diabe- tes (onset 5). Diabetes Obes Metab. 2018 Dec 9. doi: 10.1111/dom.13610. PMID:30537180
Lawton J, Blackburn M, Rankin D, Allen J, Campbell F, Leelarathna L, Tauschmann M, Thabit H, Wilinska ME, Hovorka R; APCam11 Consortium. The impact of using a closed-loop system on food choices and eating practices among people with Type 1 diabetes: a qualitative study involving adults, teenagers and parents. Diabet Med. 2018 Dec 21. doi: 10.1111/dme.13887. PMID: 30575114PMCID: PMC6510609
Lotta LA, Stewart ID, Sharp SJ, Day FR, Burgess S, Luan J, Bowker N, Cai L, Li C, Wittemans LBL, Kerrison ND, Khaw KT, McCarthy MI, O’Rahilly S, Scott RA, Savage DB, Perry JRB, Langenberg C, Wareham NJ. Association of Genetically Enhanced Lipoprotein Lipase-Mediated Lipolysis and Low-Density Lipoprotein Cholesterol-Lowering Alleles With Risk of Coronary Dis- ease and Type 2 Diabetes. JAMA Cardiol. 2018 Oct 1;3(10):957-966. PMID: 30326043PMCID: PMC6217943
Mann JP, Vreugdenhil A, Socha P, Jańczyk W, Baumann U, Rajwal S, Casswall T, Marcus C, van Mourik I, O’Rahilly S, Savage DB, Noble-Jamieson G, Lacaille F, Dabbas M, Dubern B, Kelly DA, Nobili V, Anstee European paediatric non-alcoholic fatty liver disease registry (EU- PNAFLD): Design and rationale. Contemp Clin Trials. 2018 Dec;75:67-71. doi: 10.1016/ j.cct.2018.11.003. Epub 2018 Nov 5. PMID30408605
Martin-Gallausiaux C, Larraufie P, Jarry A, Béguet-Crespel F, Marinelli L, Ledue F, Reimann F, Blottière HM, Lapaque N.Butyrate Produced by Commensal Bacteria Down-Regulates Indola- mine 2,3-Dioxygenase 1 (IDO-1) Expression via a Dual Mechanism in Human Intestinal Epitheli- al Cells. Front Immunol. 2018 Dec 11;9:2838. doi: 10.3389/fimmu.2018.02838. eCollection 2018.PMID:30619249 PMCID: PMC6297836
Menting MD, van de Beek C, Mintjens S, Wever KE, Korosi A, Ozanne SE, Limpens J, Rose- boom TJ, Hooijmans C, Painter RC. The link between maternal obesity and offspring neurobe- havior: a systematic review of animal experiments. Neurosci Biobehav Rev. 2019 Jan 3. pii: S0149-7634(18)30523-2. doi: 10.1016/j.neubiorev.2018.12.023. Review.PMID:30611800
Munthali RJ, Manyema M, Said-Mohamed R, Kagura J, Tollman S, Kahn K, Gómez-Olivé FX, Micklesfield LK, Dunger D, Norris SA. Body composition and physical activity as mediators in the relationship between socioeconomic status and blood pressure in young South African women: a structural equation model analysis. BMJ Open 2018 Dec 19;8(12):e023404. doi: 10.1136/bmjopen-2018-023404 PMID: 30573484PMCID: PMC6303607
Niu Y, Kane AD, Lusby CM, Allison BJ, Chua YY, Kaandorp JJ, Nevin-Dolan R, Ashmore TJ, Blackmore HL, Derks JB, Ozanne SE, Giussani DA.Maternal Allopurinol Prevents Cardiac Dys- function in Adult Male Offspring Programmed by Chronic Hypoxia During Pregnancy. Hyperten- sion. 2018 Oct;72(4):971-978. PMID: 30354714PMCID: PMC6135482
Pellegrinelli V, Peirce VJ, Howard L, Virtue S, Türei D, Senzacqua M, Frontini A, Dalley JW, Hor- ton AR, Bidault G, Severi I, Whittle A, Rahmouni K, Saez-Rodriguez J, Cinti S, Davies AM, Vidal- Puig A. Adipocyte-secreted BMP8b mediates adrenergic-induced remodeling of the neuro- vascular network in adipose tissue. Nat Commun. 2018 Nov 26;9(1):4974. doi: 10.1038/s41467- 018-07453-x.PMID:30478315
Petrus P, Mejhert N, Corrales P, Lecoutre S, Li Q, Maldonado E, Kulyté A, Lopez Y, Campbell M, Acosta JR, Laurencikiene J, Douagi I, Gao H, Martínez-Álvarez C, Hedén P, Spalding KL, Vidal-Puig A, Medina-Gomez G, Arner P. Transforming Growth Factor-β3 Regulates Adipocyte Number in Subcutaneous White Adipose Tissue. Rydén M.Cell Rep. 2018 Oct 16;25(3):551- 560.e5. PMID: 30332637
Petry CJ, Ong KK, Burling KA, Barker P, Goodburn SF, Perry JRB, Acerini CL, Hughes IA, Painter RC, Afink GB, Dunger DB, O’Rahilly S. Associations of vomiting and antiemetic use in pregnancy with levels of circulating GDF15 early in the second trimester: A nested case-control study. Wellcome Open Res. 2018 Sep 21;3:123. PMID: 30345390 PMCID: PMC6171563
Rached MT, Millership SJ, Pedroni SMA, Choudhury AI, Costa ASH, Hardy DG, Glegola JA, Ir- vine EE, Selman C, Woodberry MC, Yadav VK, Khadayate S, Vidal-Puig A, Virtue S, Frezza C, Withers DJ. Deletion of myeloid IRS2 enhances adipose tissue sympathetic nerve function and limits obesity. Mol Metab. 2018 Nov 28. pii: S2212-8778(18)31025-1. doi: 10.1016/ j.molmet.2018.11.010. PMID:30553769
Recino A, Gan SU, Sia KC, Sawyer Y, Trendell J, Kay R, Gribble FM, Reimann F, Foale R, No- taridou M, Holmes N, Lever A, Lee KO, Nathwani A, Cooke A, Calne R, Wallberg M. Immunosuppression overcomes insulin- and vector-specific immune responses that limit effi- cacy of AAV2/8-mediated insulin gene therapy in NOD mice. Gene Ther. 2018 Dec 4. doi: 10.1038/s41434-018-0052-5. PMID:30514969
Roche EF, McGowan A, Koulouri O, Turgeon MO, Nicholas AK, Heffernan E, El-Khairi R, Abid N, Lyons G, Halsall D, Bonomi M, Persani L, Dattani MT, Gurnell M, Bernard DJ, Schoenmakers N. A novel IGSF1 mutation in a large Irish kindred highlights the need for familial screening in the IGSF1 deficiency syndrome. Clin Endocrinol (Oxf). 2018 Dec;89(6):813-823. doi: 10.1111/ cen.13827. PMID:30086211
Rudenko O, Shang J, Munk A, Ekberg JP, Petersen N, Engelstoft MS, Egerod KL, Hjorth SA, Wu M, Feng Y, Zhou YP, Mokrosinski J, Thams P, Reimann F, Gribble F, Rehfeld JF, Holst JJ, Tree- bak JT, Howard AD, Schwartz TW. The aromatic amino acid sensor GPR142 controls metabolism through balanced regulation of pancreatic and gut hormones. Mol Metab. 2019 Jan;19:49-64. doi: 10.1016/j.molmet.2018.10.012. Epub 2018 Nov 5. PMID:30472415
Senyilmaz-Tiebe D, Pfaff DH, Virtue S, Schwarz KV, Fleming T, Altamura S, Muckenthaler MU, Okun JG, Vidal-Puig A, Nawroth P, Teleman AA. Dietary stearic acid regulates mitochondria in vivo in humans. Nat Commun. 2018 Aug 7;9(1):3129. PMID: 30087348PMCID: PMC6081440
Smith MA, Katsouri L, Virtue S, Choudhury AI, Vidal-Puig A, Ashford MLJ, Withers DJ Calcium Channel CaV2.3 Subunits Regulate Hepatic Glucose Production by Modulating Leptin-Induced Excitation of Arcuate Pro-opiomelanocortin Neurons. Cell Rep. 2018 Oct 9;25(2):278-287.e4. PMID: 30304668 PMCID: PMC6198286
Speakman JR, Loos RJF, O’Rahilly S, Hirschhorn JN, Allison DB. GWAS for BMI: a treasure trove of fundamental insights into the genetic basis of obesity. Int J Obes (Lond). 2018 Aug;42 (8):1524-1531. PMID: 29980761PMCID: PMC6115287
Tauschmann M, Thabit H, Bally L, Allen JM, Hartnell S, Wilinska ME, Ruan Y, Sibayan J, Koll- man C, Cheng P, Beck RW, Acerini CL, Evans ML, Dunger DB, Elleri D, Campbell F, Bergenstal RM, Criego A, Shah VN, Leelarathna L, Hovorka R; Closed-loop insulin delivery in suboptimally controlled type 1 diabetes: a multicentre, 12-week randomised trial. Lancet. 2018 Oct 13;392(10155):1321-1329. Erratum in: Lancet. 2018 Oct 13;392 (10155):1310 PMID: 30292578 PMCID: PMC6182127
Turco MY, Gardner L, Kay RG, Hamilton RS, Prater M, Hollinshead MS, McWhinnie A, Esposito L, Fernando R, Skelton H, Reimann F, Gribble FM, Sharkey A, Marsh SGE, O’Rahilly S, Hem- berger M, Burton GJ, Moffett A. Trophoblast organoids as a model for maternal-fetal interactions during human placentation. Nature. 2018 Dec;564(7735):263-267. doi: 10.1038/s41586-018- 0753-3. Epub 2018 Nov 28.PMID:30487605
Vidal-Puig A, Enerback S.J “Obesity-associated metabolic complications, the second wave of the tsunami” 14th Key Symposium. Intern Med. 2018 Nov;284(5):447-449. PMID: 30141829
Virtue S, Petkevicius K, Moreno-Navarrete JM, Jenkins B, Hart D, Dale M, Koulman A, Fernán- dez-Real JM, Vidal-Puig A. Peroxisome Proliferator-Activated Receptor γ2 Controls the Rate of Adipose Tissue Lipid Storage and Determines Metabolic Flexibility. Cell Rep. 2018 Aug 21;24 (8):2005-2012.e7. PMID: 30134163 PMCID: PMC6113930
Whyte MB, Shojaee-Moradie F, Sharaf SE, Jackson NC, Fielding B, Hovorka R, Mendis J, Rus- sell-Jones D, Umpleby AM.J Lixisenatide reduces chylomicron triacylglycerol due to increased clearance. Clin Endocrinol Metab. 2018 Sep 11. PMID: 30215735PMCID: PMC6300412
Zangemeister L, Grabenhorst F, Schultz W. Neural Basis for Economic Saving Strategies in Hu- man Amygdala-Prefrontal Reward Circuits. Curr Biol. 2016 Nov 21;26(22):3004-3013. doi: 10.1016/j.cub.2016.09.016. Epub 2016 Oct 20.PMID:27773572

2017

Ahmed RM, Landin-Romero R, Collet TH, van der Klaauw AA, Devenney E, Henning E, Kiernan MC, Piguet O, Farooqi IS, Hodges JR. Energy expenditure in frontotemporal dementia: a behavioural and imaging study. Brain 2017;140:171-83.
Anderberg RH, [11 authors; Gribble FM: 8, Reimann F: 9], Skibicka KP. Glucagon-like peptide-1 and its analogues act in the dorsal raphe and modulate central serotonin to reduce appetite and body weight. Diabetes 2017; 66:1062-1073.
Annamalai AK, Jeyachitra G, Jeyamithra A, Ganeshkumar M, Srinivasan KG, Gurnell M. Gestational Pituitary Apoplexy. Indian J Endocrinol Metab. 2017; 21:484-485.
Arif S, Gibson VB, Nguyen V, Bingley PJ, Todd JA, Guy C, Dunger DB, Dayan CM, Powrie J, Lorenc A, Peakman M. β-cell specific T-lymphocyte response has a distinct inflammatory phenotype in children with Type 1 diabetes compared with adults. Diabet Med. 2017; 34:419-25.
Aycan Z, Cangul H, Muzza M, Bas VN, Fugazzola L, Chatterjee VK, Persani L, Schoenmakers N. Digenic DUOX1 and DUOX2 mutations in cases with congenital hypothyroidism. J Clin Endocrinol Metab. 2017. [Epub ahead of print]
Bally L, Thabit H, Kojzar H, Mader JK, Qerimi-Hyseni J, Hartnell S, Tauschmann M, Allen JM, Wilinska ME, Pieber TR, Evans ML, Hovorka R Day-and-night glycaemic control with closed-loop insulin delivery versus conventional insulin pump therapy in free-living adults with well controlled type 1 diabetes: an open-label, randomised, crossover study. Lancet Diabetes Endocrinol. 2017; 5: 261-270.
Barnard KD, Wysocki T, Ully V, Mader JK, Pieber TR, Thabit H, Tauschmann M, Leelarathna L, Hartnell S, Acerini CL, Wilinska ME, Dellweg S, Benesch C, Arnolds S, Holzer M, Kojzar H, Campbell F, Yong J, Pichierri J, Hindmarsh P, Heinemann L, Evans ML, Hovorka R Closing the Loop in Adults, Children and Adolescents With Suboptimally Controlled Type 1 Diabetes Under Free Living Conditions: A Psychosocial Substudy. J Diabetes Sci Technol. 2017. [Epub ahead of print]
Boudellioua I, Mahamad Razali RB, Kulmanov M, Hashish Y, Bajic VB, Goncalves-Serra E, Schoenmakers N, Gkoutos GV, Schofield PN, Hoehndorf R. Semantic prioritization of novel causative genomic variants. PLoS Comput Biol. 2017; 13:e1005500.
Bulger DA, Fukushige T, Yun S, Semple RK, Hanover JA, Krause MW. Caenorhabditis elegans DAF-2 as a model for human insulin receptoropathies. G3 (Bethesda). 2017; 7:257-68.
Burke LK, Darwish T, Cavanaugh AR, Virtue S, Roth E, Morro J, Liu SM, Xia J, Dalley JW, Burling K, Chua A, Vidal-Puig A, Schwartz GJ, Blouet C. mTORC1 in AGRP neurons integrates exteroceptive and interoceptive food-related cues in the modulation of adaptive energy expenditure in mice. eLife. 2017; 6: e22848.
Church D, Cardoso L, Bradbury S, Clarke C, Stears A, Dover A, Halsall D, Semple R. Diagnosis of insulin autoimmune syndrome using polyethylene glycol precipitation and gel filtration chromatography with ex vivo insulin exchange. Clin Endocrinol (Oxf). 2017;86:347-353.
De Almeida Faria J, Duque-Guimaraes D, Carpenter AAM, Loche E, Ozanne SE. A post-weaning obesogenic diet exacerbates the detrimental effects of maternal obesity on offspring insulin signaling in adipose tissue. Sci Rep. 2017; 24: 44949.
Diederen KM, Ziauddeen H, Vestergaard MD, Spencer T, Schultz W, Fletcher PC. Dopamine Modulates Adaptive Prediction Error Coding in the Human Midbrain and Striatum. J Neurosci. 2017; 37:1708-1720.
Duque-Guimarães DE, de Almeida-Faria J, Ong TP, Ozanne SE. Pulsed SILAC as a approach for miRNA targets identification in cell culture. Methods Mol Biol. 2017;1546:149-59.
Emami A, Willinska ME, Thabit H, Leelarathna L, Hartnell S, Dellweg S, Benesch C, Mader JK, Holzer M, Kojzar H, Pieber TR, Arnolds S, Evans ML, Hovorka R. Behavioral Patterns and Associations with Glucose Control During 12-Week Randomized Free-Living Clinical Trial of Day and Night Hybrid Closed-Loop Insulin Delivery in Adults with Type 1 Diabetes. Diabetes Technol Ther. 2017; 19:433-437.
Farrington C, Stewart ZA, Barnard K, Hovorka R, Murphy HR. Experiences of closed-loop insulin delivery among pregnant women with Type 1 diabetes. Diabet Med. 2017. [Epub ahead of print]
Fernandez-Twinn DS, Gascoin G, Musial B, Carr S, Duque-Guimaraes D, Blackmore HL, Alfaradhi MZ, Loche E, Sferruzzi-Perri A, Fowden AL, Ozanne SE. Exercise rescues obese mothers’ insulin sensitivity, placental hypoxia and offspring insulin sensitivity. Sci Rep. 2017;7:44650.
García-García F, Hovorka R, Wilinska ME, Elleri D, Hernando ME. Modelling the effect of insulin on the disposal of meal-attributable glucose in type 1 diabetes. Med Biol Eng Comput. 2017; 55:271-282.
Graff M, Scott RA, [259 authors], CHARGE Consortium.; EPIC-InterAct Consortium.; PAGE Consortium., [1 author], Barroso I: 262, [18 authors], Kilpeläinen TO. Genome-wide physical activity interactions in adiposity – A meta-analysis of 200,452 adults. PLoS Genet. 2017; 13:e1006528.
Hameed S, Patterson M, Dhillo WS, Rahman SA, Ma Y, Holton C, Gogakos A, Yeo GSH, Lam BYH, Polex-Wolf J, Fenske W, Bell J, Anastasovska J, Samarut J, Bloom SR, Bassett JHD, Williams GR, Gardiner JV Thyroid Hormone Receptor Beta in the Ventromedial Hypothalamus Is Essential for the Physiological Regulation of Food Intake and Body Weight. Cell Rep. 2017;19:2202-2209.
Hendricks AE, [30 authors] O’Rahilly S: 32, Zeggini E, Barroso I: 34, Farooqi IS. Understanding Society Scientific Group; EPIC-CVD Consortium; UK10K Consortium. Rare Variant Analysis of Human and Rodent Obesity Genes in Individuals with Severe Childhood Obesity. Sci Rep. 2017; 7:4394.
Improda N, Ponmani C, Schoenmakers N, Senniappan S, Atterbury A, Barnicoat A, Chatterjee K, Dattani MT. Intrafamilial Phenotypic Variability and Consequences of Non-Compliance with Treatment in Congenital Adrenal Hyperplasia and Congenital Hypothyroidism within a Single Family. Horm Res Paediatr. 2017. [Epub ahead of print]
Justice AE, [297 authors], Barroso I 299, [16 authors], Cupples LA. Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits. Nat Commun. 2017; 8:14977.
Koseki H, Donegá M, Lam BY, Petrova V, van Erp S, Yeo GS, Kwok JC, Ffrench-Constant C, Eva R, Fawcett J. Selective Rab11 transport and the intrinsic regenerative ability of CNS axons. eLife. 2017. [Epub ahead of print]
Lam BYH, Cimino I, Polex-Wolf J, Nicole Kohnke S, Rimmington D, Iyemere V, Heeley N, Cossetti C, Schulte R, Saraiva LR, Logan DW, Blouet C, O’Rahilly S, Coll AP, Yeo GSH Heterogeneity of hypothalamic pro-opiomelanocortin-expressing neurons revealed by single-cell RNA sequencing. Mol Metab. 2017; 6:383-392.
Leiter SM, Parker VER, Welters A, Knox R, Rocha N, Clark G, Payne F, Lotta L, Harris J, Guerrero-Fernández J, González-Casado I, García-Miñaur S, Gordo G, Wareham N, Martínez-Glez V, Allison M, O’Rahilly S, Barroso I, Meissner T, Davies S, Hussain K, Temple K, Barreda-Bonis AC, Kummer S, Semple RK. Hypoinsulinaemic, hypoketotic hypoglycaemia due to mosaic genetic activation of PI3-kinase. Eur J Endocrinol. 2017; 177:175-186.
Li M, Li Y, [60 authors], CHARGE Glycemic-T2D Working Group, CHARGE Blood Pressure Working Group, [94 authors], Chu AY. SOS2 and ACP1 Loci Identified through Large-Scale Exome Chip Analysis Regulate Kidney Development and Function. J Am Soc Nephrol. 2017; 28:981-994.
Lin X, Lim IY, Wu Y, Teh AL, Chen L, Aris IM, Soh SE, Tint MT, MacIsaac JL, Morin AM, Yap F, Tan KH, Saw SM, Kobor MS, Meaney MJ, Godfrey KM, Chong YS, Holbrook JD, Lee YS, Gluckman PD, Karnani N; GUSTO study group. Developmental pathways to adiposity begin before birth and are influenced by genotype, prenatal environment and epigenome. BMC Med. 2017; 15:50.
Lotta LA, [29 authors], O’Rahilly S, Scott RA. Integrative genomic analysis implicates limited peripheral adipose storage capacity in the pathogenesis of human insulin resistance. Nat Genet. 2017; 49:17-26. Corrigendum 2017; 49:317.
Ma D, Ozanne SE, Guest PC A Protocol for Producing the Maternal Low-Protein Rat Model: A Tool for Preclinical Proteomic Studies. Adv Exp Med Biol. 2017; 974:251-255.
Maniero C, Garg S, Zhao W, Johnson TI, Zhou J, Gurnell M, Brown MJ. NEFM (Neurofilament Medium) Polypeptide, a Marker for Zona Glomerulosa Cells in Human Adrenal, Inhibits D1R (Dopamine D1 Receptor)-Mediated Secretion of Aldosterone. Hypertension. 2017; 70:357-364.
Manning A, [192 authors], O’Rahilly SP: 194, [6 authors], Barroso I: 201, [60 authors], Lindgren CM. A Low-Frequency Inactivating AKT2 Variant Enriched in the Finnish Population Is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk. Diabetes. 2017; 66:2019-2032.
Martínez-Sánchez N, [21 authors], Chatterjee K: 22, [5 authors], Coll AP: 28, Vidal-Puig A: 29, [10 authors], López M. Hypothalamic AMPK-ER Stress-JNK1 Axis Mediates the Central Actions of Thyroid Hormones on Energy Balance. Cell Metab. 2017; 26:212-229.
Mele L, Carobbio S, Brindani N, Curti C, Rodriguez-Cuenca S, Bidault G, Mena P, Zanotti I, Vacca M, Vidal-Puig A, Del Rio D Phenyl-γ-valerolactones, flavan-3-ol colonic metabolites, protect brown adipocytes from oxidative stress without affecting their differentiation or function. Mol Nutr Food Res. 2017. [Epub ahead of print]
Minic M, Rocha N, Harris J, Groeneveld MP, Leiter S, Wareham N, Sleigh A, De Lonlay P, Hussain K, O’Rahilly S, Semple RK Constitutive activation of AKT2 in humans leads to hypoglycemia without fatty liver or metabolic dyslipidemia. J Clin Endocrinol Metab. 2017; 102:2914-2921.
Musial B, Vaughan O, Fernandez-Twinn DS, Voshol P, Ozanne SE, Fowden A, Sferruzzi-Perri A. A Western-style obesogenic diet alters maternal metabolic physiology with consequences for fetal nutrient acquisition in mice. J Physiol. 2017. [Epub ahead of print]
Nøhr AC, Shehata MA, Hauser AS, Isberg V, Mokrosinski J, Andersen KB, Farooqi IS, Pedersen DS, Gloriam DE, Bräuner-Osborne H. The orphan G protein-coupled receptor GPR139 is activated by the peptides: Adrenocorticotropic hormone (ACTH), α-, and β-melanocyte stimulating hormone (α-MSH, and β-MSH), and the conserved core motif HFRW. Neurochem Int. 2017;102:105-13.
Nus M, Sage AP, Lu Y, Masters L, Lam BYH, Newland S, Weller S, Tsiantoulas D, Raffort J, Marcus D, Finigan A, Kitt L, Figg N, Schirmbeck R, Kneilling M, Yeo GSH, Binder CJ, de la Pompa JL, Mallat Z. Marginal zone B cells control the response of follicular helper T cells to a high-cholesterol diet. Nat Med. 2017; 23:601-610.
Olcese C, [40 authors], UK10K Rare Group, [4 authors], Mitchison HM. X-linked primary ciliary dyskinesia due to mutations in the cytoplasmic axonemal dynein assembly factor PIH1D3. Nat Commun. 2017; 8:14279.
O’Reilly MW, Kempegowda P, Walsh M, Taylor AE, Manolopoulos KN, Allwood JW, Semple RK, Hebenstreit D, Dunn WB, Tomlinson JW, Arlt W.J AKR1C3-mediated adipose androgen generation drives lipotoxicity in women with polycystic ovary syndrome. Clin Endocrinol Metab. 2017; [Epub ahead of print].
Ouyang J, Hardy R, Brown M, Helliwell T, Gurnell M, Cuthbertson DJ. 11C-metomidate PET-CT scanning can identify aldosterone-producing adenomas after unsuccessful lateralisation with CT/MRI and adrenal venous sampling. J Hum Hypertens. 2017; 31:483-484.
Pestana D, Teixeira D, Meireles M, Marques C, Norberto S, Sá C, Fernandes VC, Correia-Sá L, Faria A, Guardão L, Guimarães JT, Cooper WN, Sandovici I, Domingues VF, Delerue-Matos C, Monteiro R, Constância M, Calhau C.Adipose tissue dysfunction as a central mechanism leading to dysmetabolic obesity triggered by chronic exposure to p,p’-DDE. Sci Rep. 2017; 7:2738.
Petry CJ, Mooslehner K, Prentice P, Hayes MG, Nodzenski M, Scholtens DM, Hughes IA, Acerini CL, Ong KK, Lowe WL Jr, Dunger DB. Associations between a fetal imprinted gene allele score and late pregnancy maternal glucose concentrations. Diabetes Metab. 2017. [Epub ahead of print]
Pompa A, De Marchis F, Pallotta MT, Benitez-Alfonso Y, Jones A, Schipper K, Moreau K, Žárský V, Di Sansebastiano GP, Bellucci M. Unconventional Transport Routes of Soluble and Membrane Proteins and Their Role in Developmental Biology. Int J Mol Sci. 2017; 18(4).
Psichas A, Tolhurst G, Brighton CA, Gribble FM, Reimann F. Mixed Primary Cultures of Murine Small Intestine Intended for the Study of Gut Hormone Secretion and Live Cell Imaging of Enteroendocrine Cells. J Vis Exp. 2017; 122:55687.
Rocha NM, [14 authors], Barroso I: 16, [10 authors], O’Rahilly SI: 27, [2 authors], Savage DB: 30, Semple RK Human biallelic MFN2 mutations induce mitochondrial dysfunction, upper body adipose hyperplasia, and suppression of leptin expression. eLife. 2017; 6: e23813.
Ruan Y, Thabit H, Leelarathna L, Hartnell S, Willinska ME, Tauschmann M, Dellweg S, Benesch C, Mader JK, Holzer M, Kojzar H, Evans ML, Pieber TR, Arnolds S, Hovorka R; AP@home consortium. Faster insulin action is associated with improved glycemic outcomes during closed-loop insulin delivery and sensor-augmented pump therapy in adults with type 1 diabetes. Diabetes Obes Metab. 2017. [Epub ahead of print]
Sferruzzi-Perri AN, Sandovici I, Constancia M, Fowden AL. Placental phenotype and the insulin-like growth factors: resource allocation to fetal growth. J Physiol. 2017; 595:5057-5093.
Taku N, Gurnell M, Burnet N, Jena R. Time dependence of radiation-induced hypothalamic-pituitary axis dysfunction in adults treated for non-pituitary, intracranial neoplasms. Clin Oncol (R Coll Radiol). 2017;29:34-41.
Teo AE, Garg S, Johnson TI, Zhao W, Zhou J, Gomez-Sanchez CE, Gurnell M, Brown MJ. Physiological and Pathological Roles in Human Adrenal of the Glomeruli-Defining Matrix Protein NPNT (Nephronectin). Hypertension. 2017; 69:1207-1216. Apr 17.
Thabit H, Hartnell S, Allen JM, Lake A, Wilinska ME, Ruan Y, Evans ML, Coll AP, Hovorka R. Closed-loop insulin delivery in inpatients with type 2 diabetes: a randomised, parallel-group trial. R.Lancet Diabetes Endocrinol. 2017; 5:117-124.
Tripolszki K, Farkas K, Sulák A, Szolnoky G, Duga B, Melegh B, Knox RG, Parker VER, Semple RK, Kemény L, Széll M, Nagy N. Atypical neurofibromatosis type 1 with unilateral limb hypertrophy mimicking overgrowth syndrome. Clin Exp Dermatol. 2017. [Epub ahead of print]
Tsoukalas M, Psichas A, Reimann F, Gribble FM, Lobstein A, Urbain A. Pregnane glycosides from Cynanchum menarandrense. Steroids. 2017; 125:27-32.
Tsuchiya Y, Peak-Chew S, Newell C, Miller-Aidoo S, Mangal S, Zhyvoloup A, Baković J, Malanchuk O, Pereira G, Kotiadis V, Szabadkai G, Duchen M, Campbell M, Rodriguez Cuenca S, Vidal-Puig A, James A, Murphy MP, Filonenko V, Skehel M, Gout I. Protein CoAlation: A Redox-Regulated Protein Modification by Coenzyme A in Mammalian Cells. Biochem J. 2017; 474:2489-2508.
van der Klaauw AA, Ziauddeen H, Keogh JM, Henning E, Dachi S, Fletcher PC, Farooqi IS Oxytocin administration suppresses hypothalamic activation in response to visual food cues. Sci Rep. 2017; 7:4266.eo CR, Agrawal M, Hoon S, Shabbir A, Shrivastava MK, Huang S, Khoo CM, Chhay V, Yassin MS, Tai ES, Vidal-Puig A, Toh SA. SGBS cells as a model of human adipocyte browning: A comprehensive comparative study with primary human white subcutaneous adipocytes. Sci Rep. 2017; 7:4031.
van Gucht ALM, Moran C, Meima ME, Visser WE, Chatterjee K, Visser TJ, Peeters RP. Resistance to Thyroid Hormone due to Heterozygous Mutations in Thyroid Hormone Receptor Alpha. Curr Top Dev Biol. 2017; 125:337-355.
Vasudevan P, Powell C, Nicholas AK, Scudamore I, Greening J, Park SM, Schoenmakers N. Intrauterine death following intraamniotic triiodothyronine and thyroxine therapy for fetal goitrous hypothyroidism associated with polyhydramnios and caused by a thyroglobulin mutation. Endocrinol Diabetes Metab Case Rep. 2017; 17-0040.
Wheeler SE, Stacey HM, Nahaei Y, Hale SJ, Hardy AB, Reimann F, Gribble FM, Larraufie P, Gaisano HY, Brubaker PL. The SNARE Protein, Syntaxin1a, Plays an Essential Role in Biphasic Exocytosis of the Incretin Hormone, Glucagon-Like Peptide-1. Diabetes. 2017; 66:2327-2338.
Yeo CR, Agrawal M, Hoon S, Shabbir A, Shrivastava MK, Huang S, Khoo CM, Chhay V, Yassin MS, Tai ES, Vidal-Puig A, Toh SA. SGBS cells as a model of human adipocyte browning: A comprehensive comparative study with primary human white subcutaneous adipocytes. Sci Rep. 2017: 7:4031.

2016

(* Open access publications)

Adriaenssens AE, Svendsen B, Lam BY, Yeo GS, Holst JJ, Reimann F, Gribble FM. Transcriptomic profiling of pancreatic alpha, beta and delta cell populations identifies delta cells as a principal target for ghrelin in mouse islets. Diabetologia 2016;59:2156-65. *
Ahmed RM, Irish M, Henning E, Dermody N, Bartley L, Kiernan MC, Piguet O, Farooqi S, Hodges JR. Assessment of eating behavior disturbance and associated neural networks in frontotemporal dementia. JAMA Neurol. 2016;73:282-90.
Aiken CE, Tarry-Adkins JL, Penfold NC, Dearden L, Ozanne SE. Decreased ovarian reserve, dysregulation of mitochondrial biogenesis, and increased lipid peroxidation in female mouse offspring exposed to an obesogenic maternal diet. FASEB J. 2016;30:1548-56. *
Alfaradhi MZ, Kusinski LC, Fernandez-Twinn DS, Pantaleão LC, Carr SK, Ferland-McCollough D, Yeo GS, Bushell M, Ozanne SE. Maternal obesity in pregnancy developmentally programs adipose tissue inflammation in young, lean male mice offspring. Endocrinology 2016;157:4246-56. *
Allison BJ, Kaandorp JJ, Kane AD, Camm EJ, Lusby C, Cross CM, Nevin-Dolan R, Thakor AS, Derks JB, Tarry-Adkins JL, Ozanne SE, Giussani DA. Divergence of mechanistic pathways mediating cardiovascular aging and developmental programming of cardiovascular disease. FASEB J. 2016;30:1968-75. *
Anesten F, Holt MK, Schéle E, Pálsdóttir V, Reimann F, Gribble FM, Safari C, Skibicka KP, Trapp S, Jansson JO. Preproglucagon neurons in the hindbrain have IL-6 receptor-α and show Ca2+ influx in response to IL-6. Am J Physiol Regul Integr Comp Physiol. 2016;311:R115-23. *
Baig S, Parvaresh Rizi E, Shabeer M, Chhay V, Mok SF, Loh TP, Magkos F, Vidal-Puig A, Tai ES, Khoo CM, Toh SA. Metabolic gene expression profile in circulating mononuclear cells reflects obesity-associated metabolic inflexibility. Nutr Metab (Lond). 2016;13:74. *
Boldt K, [54 authors], Group UKRD. An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. Nat Commun. 2016;7:11491. *
Breen DP, Nombela C, Vuono R, Jones PS, Fisher K, Burn DJ, Brooks DJ, Reddy AB, Rowe JB, Barker RA. Hypothalamic volume loss is associated with reduced melatonin output in Parkinson’s disease. Mov Disord. 2016;31:1062-6. *
Burberry A, [15 authors; Merkle FT: 9], Eggan K. Loss-of-function mutations in the C9ORF72 mouse ortholog cause fatal autoimmune disease. Sci Transl Med. 2016;8:347ra93. *
Burke LK, [17 authors], Evans ML, Heisler LK. Sex difference in physical activity, energy expenditure and obesity driven by a subpopulation of hypothalamic POMC neurons. Mol Metab. 2016;5:245-52. *
Carmody D, Ladsaria SS, Buikema RK, Semple RK, Greeley SAW. Successful rhIGF1 treatment for over 5 years in a patient with severe insulin resistance due to homozygous insulin receptor mutation. Diabet Med. 2016;33:e8-12. *
Castillo SD, [26 authors; Semple RK: 23], Vanhaesebroeck B. Somatic activating mutations in Pik3ca cause sporadic venous malformations in mice and humans. Sci Transl Med. 2016;8:332ra43.
Challis BG, Kandasamy N, Powlson AS, Koulouri O, Annamalai AK, Happerfield L, Marker AJ, Arends MJ, Nik-Zainal S, Gurnell M. Familial adrenocortical carcinoma in association with Lynch syndrome. J Clin Endocrinol Metab. 2016;101:2269-72. *
Challis BG, Lim CT, Cluroe A, Cameron E, O’Rahilly S. The McKittrick-Wheelock syndrome: a rare cause of curable diabetes. Endocrinol Diabetes Metab Case Rep. 2016;160013. *
Collet TH, van der Klaauw AA, Henning E, Keogh JM, Suddaby D, Dachi SV, Dunbar S, Kelway S, Dickson SL, Farooqi IS, Schmid SM. The sleep/wake cycle is directly modulated by changes in energy balance. Sleep 2016;39:1691-700. *
Correia-Melo C, [26 authors; Vidal-Puig A: 19], Passos JF. Mitochondria are required for pro-ageing features of the senescent phenotype. EMBO J. 2016;35:724-42.*
Dalgaard K, [28 authors; Yeo GS: 19, O’Rahilly S: 20, Coll AP: 27], Pospisilik JA. Trim28 haploinsufficiency triggers bi-stable epigenetic obesity. Cell 2016;164:353-64. *
Demir T, Onay H, Savage DB, Temeloglu E, Uzum AK, Kadioglu P, Altay C, Ozen S, Demir L, Cavdar U, Akinci B. Familial partial lipodystrophy linked to a novel peroxisome proliferator activator receptor -γ (PPARG) mutation, H449L: a comparison of people with this mutation and those with classic codon 482 Lamin A/C (LMNA) mutations. Diabet Med. 2016;33:1445-50.
Dennedy MC, Annamalai AK, Prankerd Smith O, Freeman N, Vengopal K, Graggaber J, Koulouri O, Powlson AS, Shaw A, Halsall DJ, Gurnell M. Low DHEAS: a sensitive and specific test for detection of subclinical hypercortisolism in adrenal incidentalomas. J Clin Endocrinol Metab. 2016;jc20162718.
Diederen KM, Spencer T, Vestergaard MD, Fletcher PC, Schultz W. Adaptive prediction error coding in the human midbrain and striatum facilitates behavioural adaptation and learning efficiency. Neuron. 2016;90:1127-38. doi: *
Duque-Guimarães DE, de Almeida-Faria J, Ong TP, Ozanne SE. Pulsed SILAC as a approach for miRNA targets identification in cell culture. Methods Mol Biol. 2017;1546:149-59.
Dusaulcy R, Handgraaf S, Heddad-Masson M, Visentin F, Vesin C, Reimann F, Gribble F, Philippe J, Gosmain Y. α-cell dysfunctions and molecular alterations in male insulinopenic diabetic mice are not completely corrected by insulin. Endocrinology 2016;157:536-47.
Edgar RS, Stangherlin A, Nagy AD, Nicoll MP, Efstathiou S, O’Neill JS, Reddy AB. Cell autonomous regulation of herpes and influenza virus infection by the circadian clock. Proc Natl Acad Sci USA. 2016;113:10085-90. *
Ekberg JH, [14 authors; Gribble FM: 10, Reiman F: 11], Schwartz TW. GPR119, a major enteroendocrine sensor of dietary triglyceride metabolites coacting in synergy With FFA1 (GPR40). Endocrinology 2016;157:4561-9.
Farrington C, Allen J, Tauschmann M, Randell T, Trevelyan N, Hovorka R. Factors affecting recruitment of participants for studies of diabetes technology in newly diagnosed youth with type 1 diabetes: a qualitative focus group study with parents and children. Diabetes Technol Ther. 2016;18:568-73. *
Flint TR, Janowitz T, Connell CM, Roberts EW, Denton AE, Coll AP, Jodrell DI, Fearon DT. Tumor-induced IL-6 reprograms host metabolism to suppress anti-tumor immunity. Cell Metab. 2016;24:672-84. *
Fuchsberger C, [301 authors; O’Rahilly SP: 208], McCarthy MI. The genetic architecture of type 2 diabetes. Nature 2016;536:41-7. *
Gathercole LL, [13 authors; Semple RK: 11], Geberhiwot T. Advanced non-alcoholic fatty liver disease and adipose tissue fibrosis in patients with Alström syndrome. Liver Int. 2016;36:1704-12.
Giraud K, Pontin M, Sharples LD, Fletcher P, Dalgleish T, Eden A, Jenkins DP, Vuylsteke A. Use of a structured mirrors intervention does not reduce delirium incidence but may improve factual memory encoding in cardiac surgical ICU patients aged over 70 years: a pilot time-cluster randomized controlled trial. Front Aging Neurosci. 2016;8:228.
Gripp KW, Baker L, Kandula V, Conard K, Scavina M, Napoli JA, Griffin GC, Thacker M, Knox RG, Clark GR, Parker VER, Semple R, Mirzaa G, Keppler-Noreuil KM. Nephroblastomatosis or Wilms tumor in a fourth patient with a somatic PIK3CA mutation. Am J Med Genet A. 2016;170:2559-69.
Groeneveld MP, Brierley GV, Rocha NM, Siddle K, Semple RK. Acute knockdown of the insulin receptor or its substrates Irs1 and 2 in 3T3-L1 adipocytes suppresses adiponectin production. Sci Rep. 2016 Feb 18;6:21105. *
Hall Z, Bond NJ, Ashmore T, Sanders F, Ament Z, Wang X, Murray AJ, Bellafante E, Virtue S, Vidal-Puig A, Allison M, Davies SE, Koulman A, Vacca M, Griffin JL. Lipid zonation and phospholipid remodeling in nonalcoholic fatty liver disease. Hepatology 2016;epub ahead of print.
Heppolette CA, Chen JH, Carr SK, Palmer DB, Ozanne SE. The effects of aging and maternal protein restriction during lactation on thymic involution and peripheral immunosenescence in adult mice. Oncotarget 2016;7:6398-409. *
Holland ML, Lowe R, Caton PW, Gemma C, Carbajosa G, Danson AF, Carpenter AA, Loche E, Ozanne SE, Rakyan VK. Early-life nutrition modulates the epigenetic state of specific rDNA genetic variants in mice. Science 2016;353:495-8.
Hollands GJ, Marteau TM, Fletcher PC. Non-conscious processes in changing health-related behaviour: a conceptual analysis and framework. Health Psychol Rev. 2016;10:381-394. *
Huang-Doran I, [18 authors], Savage DB, Murphy R, O’Rahilly S, Barroso I, Semple RK. Insulin resistance uncoupled from dyslipidemia due to C-terminal PIK3R1 mutations. JCI Insight. 2016;1:e88766. *
Inman M, Daneman D, Curtis J, Sochett E, Elia Y, Dunger DB, Deanfield J, Mahmud FH. Assessing social determinants of health in a pediatric diabetes clinical research trial: Are recruited subjects representative of the larger clinical population? Diabetes Res Clin Pract. 2016;113:41-3.
Joustra SD, Heinen CA, Schoenmakers N, Bonomi M, Ballieux BEPB, Turgeon MO, Bernard DJ, Fliers E, van Trotsenburg ASP, Losekoot M, Persani L, Wit JM, Biermasz NR, Pereira AM, Oostdijk W, Group ICC. IGSF1 deficiency: lessons from an extensive case series and recommendations for clinical management. J Clin Endocrinol Metab. 2016;101:1627-36. *
Joustra SD, Schoenmakers N, [26 authors; Chatterjee K: 22], van Trotsenburg AS. The IGSF1 deficiency syndrome: characteristics of male and female patients. J Clin Endocrinol Metab. 2013;98:4942-52.
Kandasamy N, Garfinkel SN, Page L, Hardy B, Critchley HD, Gurnell M, Coates JM. Interoceptive ability predicts survival on a London trading floor. Sci Rep. 2016;6:32986. *
Kilpeläinen TO, [175 authors; Savage DB: 99], Loos RJ. Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels. Nat Commun. 2016;7:10494. *
Kim HS, [15 authors; Yeo GS: 9], Lee MG. A coding variant in FTO confers susceptibility to thiopurine-induced leukopenia in East Asian patients with IBD. Gut 2016;pii:gutjnl-2016-311921.
Koulouri O, Hoole AC, English P, Allinson K, Antoun N, Cheow H, Burnet NG, Donnelly N, Mannion RJ, Gurnell M. Localisation of an occult thyrotropinoma with (11)C-methionine PET-CT before and after somatostatin analogue therapy. Lancet Diabetes Endocrinol. 2016;4:1050.
Koulouri O, [28 authors], Gurnell M. Successful treatment of residual pituitary adenoma in persistent acromegaly following localisation by 11C-methionine PET co-registered with MRI. Eur J Endocrinol. 2016;175:485-98.
Koulouri O, Nicholas AK, Schoenmakers E, Mokrosinski J, Lane F, Cole T, Kirk J, Farooqi IS, Chatterjee VK, Gurnell M, Schoenmakers N. A novel thyrotropin-releasing hormone receptor missense mutation (P81R) in central congenital hypothyroidism. J Clin Endocrinol Metab. 2016;101:847-51. *
Kuhre RE, Wewer Albrechtsen NJ, Deacon CF, Balk-Møller E, Rehfeld JF, Reimann F, Gribble FM, Holst JJ. Peptide production and secretion in GLUTag, NCI-H716, and STC-1 cells: a comparison to native L-cells. J Mol Endocrinol. 2016;56:201-11.
Langeveld M, Tan CY, Soeters MR, Virtue S, Ambler GK, Watson LP, Murgatroyd PR, Chatterjee VK, Vidal-Puig A. Mild cold effects on hunger, food intake, satiety and skin temperature in humans. Endocr Connect. 2016;5:65-73. *
Leelarathna L, Thabit H, Hartnell S, Willinska ME, Dellweg S, Benesch C, Mader JK, Holzer M, Kojzar H, Evans ML, Arnolds S, Pieber TR, Hovorka R, AP@home Consortium. Rapid benefits of structured optimization and sensor-augmented insulin pump therapy in adults with type 1 diabetes. J Diabetes Sci Technol. 2016;pii:1932296816654715.
Lie S, Morrison JL, Williams-Wyss O, Suter CM, Humphreys DT, Ozanne SE, Zhang S, MacLaughlin SM, Kleemann DO, Walker SK, Roberts CT, McMillen IC. Impact of maternal undernutrition around the time of conception on factors regulating hepatic lipid metabolism and microRNAs in singleton and twin fetuses. Am J Physiol Endocrinol Metab. 2016;310:E148-59. *
Lotta LA, [26 authors; O’Rahilly S: 25], Langenberg C. Genetic predisposition to an impaired metabolism of the branched-chain amino acids and risk of type 2 diabetes: a mendelian randomisation analysis. PLoS Med. 2016;13:e1002179. *
Lotta LA, [39 authors; O’Rahilly S: 35], Wareham NJ. Association between low-density lipoprotein cholesterol-lowering genetic variants and risk of type 2 diabetes: a meta-analysis. JAMA 2016;316:1383-91.
Lu L, Koulman A, Petry CJ, Jenkins B, Matthews L, Hughes IA, Acerini CL, Ong KK, Dunger DB. An unbiased lipidomics approach identifies early second trimester lipids predictive of maternal glycemic traits and gestational diabetes mellitus. Diabetes Care 2016;39:2232-9. *
Maahs DM, [22 authors; Hovorka R: 11], Lum JW. Outcome Measures for Artificial Pancreas Clinical Trials: A Consensus Report. Diabetes Care 2016;39:1175-9.
Majithia AR, [24 authors, O’Rahilly S: 19], Altshuler D. Prospective functional classification of all possible missense variants in PPARG. Nat Genet. 2016;48:1570-5. *
Manning KE, McAllister CJ, Ring HA, Finer N, Kelly CL, Sylvester KP, Fletcher PC, Morrell NW, Garnett MR, Manford MR, Holland AJ. Novel insights into maladaptive behaviours in Prader-Willi syndrome: serendipitous findings from an open trial of vagus nerve stimulation. J Intellect Disabil Res. 2016;60:149-55. *
Marelli F, Carra S, Agostini M, Cotelli F, Peeters R, Chatterjee K, Persani L. Patterns of thyroid hormone receptor expression in zebrafish and generation of a novel model of resistance to thyroid hormone action. Mol Cell Endocrinol. 2016;424:102-17.
Martin-Gronert MS, Fernandez-Twinn DS, Bushell M, Siddle K, Ozanne SE. Cell-autonomous programming of rat adipose tissue insulin signalling proteins by maternal nutrition. Diabetologia 2016;59:1266-75. *
Martin-Gronert MS, Stocker CJ, Wargent ET, Cripps RL, Garfield AS, Jovanovic Z, D’Agostino G, Yeo GS, Cawthorne MA, Arch JR, Heisler LK, Ozanne SE. 5-HT2A and 5-HT2C receptors as hypothalamic targets of developmental programming in male rats. Dis Model Mech. 2016;9:401-12.*
Martínez R, Kapravelou G, Porres JM, Melesio AM, Heras L, Cantarero S, Gribble FM, Parker H, Aranda P, López-Jurado M. Medicago sativa L, a functional food to relieve hypertension and metabolic disorders in a spontaneously hypertensive rat model. Journal of Functional Foods 2016;26:470-84.
Medic N, Ziauddeen H, Ersche KD, Farooqi IS, Bullmore ET, Nathan PJ, Ronan L, Fletcher PC. Increased body mass index is associated with specific regional alterations in brain structure. Int J Obes (Lond). 2016;40:1177-82. *
Medic N, Ziauddeen H, Forwood SE, Davies KM, Ahern AL, Jebb SA, Marteau TM, Fletcher PC. The presence of real food usurps hypothetical health value judgment in overweight people. 2016;3.pii: ENEURO.0025-16.2016. *
Meek CL, Lewis HB, Vergese B, Park A, Reimann F, Gribble F. The effect of encapsulated glutamine on gut peptide secretion in human volunteers. Peptides 2016;77:38-46. *
Morton NM, [31 authors; Vidal-Puig A: 29], Horvat S. Genetic identification of thiosulfate sulfurtransferase as an adipocyte-expressed antidiabetic target in mice selected for leanness. Nat Med. 2016;22:771-9.
Moss CE, Glass LL, Diakogiannaki E, Pais R, Lenaghan C, Smith DM, Wedin M, Bohlooly-Y M, Gribble FM, Reimann F. Lipid derivatives activate GPR119 and trigger GLP-1 secretion in primary murine L-cells. Peptides 2016 Mar;77:16-20. *
Musial B, Fernandez-Twinn DS, Vaughan OR, Ozanne SE, Voshol P, Sferruzzi-Perri AN, Fowden AL. Proximity to delivery alters insulin sensitivity and glucose metabolism in pregnant mice. Diabetes 2016;65:851-60. *
Neupane S, Peverall R, Richmond G, Blaikie TP, Taylor D, Hancock G, Evans ML. Exhaled breath isoprene rises during hypoglycemia in type 1 diabetes. Diabetes Care 2016;39:e97-8.
Nicholas AK, [33 authors], Chatterjee VK, Anderson CA, Schoenmakers N. Comprehensive screening of eight known causative genes in congenital hypothyroidism with gland-in-situ. J Clin Endocrinol Metab. 2016;101:4521-31. *
Nicholas AK, Jaleel S, Lyons G, Schoenmakers E, Dattani MT, Crowne E, Bernhard B, Kirk J, Roche EF, Chatterjee VK, Schoenmakers N. Molecular spectrum of TSHβ subunit gene defects in central hypothyroidism in the UK and Ireland. Clin Endocrinol (Oxf). 2016; Epub ahead of print.
Novoselova TV, Larder R, Rimmington D, Lelliott C, Wynn EH, Gorrigan RJ, Tate PH, Guasti L; Sanger Mouse Genetics Project, O’Rahilly S, Clark AJ, Logan DW, Coll AP, Chan LF. Loss of Mrap2 is associated with Sim1 deficiency and increased circulating cholesterol. J Endocrinol. 2016;230:13-26. *
Overduin J, Collet TH, Medic N, Henning E, Keogh JM, Forsyth F, Stephenson C, Kanning MW, Ruijschop RM, Farooqi IS, van der Klaauw AA. Failure of sucrose replacement with the non-nutritive sweetener erythritol to alter GLP-1 or PYY release or test meal size in lean or obese people. Appetite 2016;107:596-603. *
Pais R, Gribble FM, Reimann F. Signalling pathways involved in the detection of peptones by murine small intestinal enteroendocrine L-cells. Peptides 2016;77:9-15. *
Pais R, Rievaj J, Larraufie P, Gribble F, Reimann F. Angiotensin II type 1 receptor-dependent GLP-1 and PYY secretion in mice and humans. Endocrinology 2016;157:3821-3831. *
Pais R, Rievaj J, Meek C, De Costa G, Jayamaha S, Alexander RT, Reimann F, Gribble F. Role of enteroendocrine L-cells in arginine vasopressin-mediated inhibition of colonic anion secretion. J Physiol. 2016;594:4865-78. *
Parvaresh Rizi E, Baig S, Shabeer M, Teo Y, Mok SF, Loh TP, Magkos F, Virtue S, Vidal-Puig A, Tai ES, Khoo CM, Toh SA. Meal rich in carbohydrate, but not protein or fat, reveals adverse immunometabolic responses associated with obesity. Nutr J. 2016;15:100. *
Pauliina Markkula S, Lyons D, Yueh CY, Riches C, Hurst P, Fielding B, Heisler LK, Evans ML. Intracerebroventricular catalase reduces hepatic insulin sensitivity and increases responses to hypoglycemia in rats. Endocrinology 2016;157:4669-76. *
Petry CJ, Sanz Marcos N, Pimentel G, Hayes MG, Nodzenski M, Scholtens DM, Hughes I A, Acerini CL, Ong KK, Lowe WL, Dunger DB. Associations between fetal imprinted genes and maternal blood pressure in pregnancy. Hypertension 2016;68:1459-66.
Powlson AS, Challis BG, Halsall DJ, Schoenmakers E, Gurnell M. Nephrogenic syndrome of inappropriate antidiuresis secondary to an activating mutation in the arginine vasopressin receptor AVPR2. Clin Endocrinol (Oxf). 2016;85:306-12.
Pozzilli P, Battelino T, Danne T, Hovorka R, Jarosz-Chobot P, Renard E. Continuous subcutaneous insulin infusion in diabetes: patient populations, safety, efficacy, and pharmacoeconomics. Diabetes Metab Res Rev. 2016;32:21-39. *
Psichas A, Glass LL, Sharp SJ, Reimann F, Gribble FM. Galanin inhibits GLP-1 and GIP secretion via the GAL1 receptor in enteroendocrine L and K cells. Br J Pharmacol. 2016;173:888-98. *
Raffan E, [19 authors], Yeo GS, O’Rahilly S. A deletion in the canine POMC Gene is associated with weight and appetite in obesity-prone Labrador Retriever dogs. Cell Metab. 2016;23:893-900. *
Rahbari R, Wuster A, Lindsay SJ, Hardwick RJ, Alexandrov LB, Al Turki S, Dominiczak A, Morris A, Porteous D, Smith B, Stratton MR, UK10K Consortium, Hurles ME. Timing, rates and spectra of human germline mutation. Nat Genet. 2016;48:126-33. *
Rey G, Valekunja UK, Feeney KA, Wulund L, Milev NB, Stangherlin A, Ansel-Bollepalli L, Velagapudi V, O’Neill JS, Reddy AB. The pentose phosphate pathway regulates the circadian clock. Cell Metab. 2016;24:462-73. *
Richards P, Pais R, Habib AM, Brighton CA, Yeo GS, Reimann F, Gribble FM. High fat diet impairs the function of glucagon-like peptide-1 producing L-cells. Peptides 2016;77:21-7. *
Rodriguez-Cuenca S, Whyte L, Hagen R, Vidal-Puig A, Fuller M. Stearoyl-CoA Desaturase 1 is a key determinant of membrane lipid composition in 3T3-L1 adipocytes. PLoS One 2016;11:e0162047. *
Ronan L, Alexander-Bloch AF, Wagstyl K, Farooqi S, Brayne C, Tyler LK; Cam-CAN, Fletcher PC. Obesity associated with increased brain age from midlife. Neurobiol Aging. 2016;47:63-70. *
Rowe ER, Mimmack ML, Barbosa AD, Haider A, Isaac I, Ouberai MM, Thiam AR, Patel S, Saudek V, Siniossoglou S, Savage DB. Conserved amphipathic helices mediate lipid droplet targeting of perilipins 1-3. J Biol Chem. 2016;291:6664-78. *
Ruan Y, [12 authors], Hovorka R, AP@home Consortium. Variability of insulin requirements over 12 weeks of closed-loop insulin delivery in adults with type 1 diabetes. Diabetes Care 2016;39:830-2.
Sandovici I, Hammerle CM, Cooper WN, Smith NH, Tarry-Adkins JL, Dunmore BJ, Bauer J, Andrews SR, Yeo GS, Ozanne SE, Constância M. Ageing is associated with molecular signatures of inflammation and type 2 diabetes in rat pancreatic islets. Diabetologia 2016;59:502-11. *
Sanghez V, Cubuk C, Sebastian-Leon P, Carobbio S, Dopazo J, Vidal-Puig A, Bartolomucci A. Chronic subordination stress selectively downregulates the insulin signaling pathway in liver and skeletal muscle but not in adipose tissue of male mice. Stress 2016;19:214-24. *
Santos DP, Kiskinis E, Eggan K, Merkle FT. Comprehensive protocols for CRISPR/Cas9-based gene editing in human pluripotent stem cells. Curr Protoc Stem Cell Biol. 2016;38:5B.6.1-5B.6.60. *
Sayers SR, Reimann F, Gribble FM, Parker H, Zac-Varghese S, Bloom SR, Foretz M, Viollet B, Rutter GA. Proglucagon promoter Cre-mediated AMPK deletion in mice increases circulating GLP-1 levels and oral glucose tolerance. PLoS One 2016;11:e0149549. *
Schoenmakers E, [14 authors; Farooqi S: 12], Chatterjee K. Mutation in human selenocysteine transfer RNA selectively disrupts selenoprotein synthesis. J Clin Invest. 2016;126:992-6. *
Schooneman MG, Napolitano A, Houten SM, Ambler GK, Murgatroyd PR, Miller SR, Hollak CE, Tan CY, Virtue S, Vidal-Puig A, Nunez DJ, Soeters MR. Assessment of plasma acylcarnitines before and after weight loss in obese subjects. Arch Biochem Biophys. 2016;606:73-80.
Scott RA, [148 authors; O’Rahilly S: 138], Waterworth DM. A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease. Sci Transl Med. 2016;8:341ra76. *
Sefton C, Harno E, Davies A, Small H, Allen TJ, Wray JR, Lawrence CB, Coll AP, White A. Elevated hypothalamic glucocorticoid levels are associated with obesity and hyperphagia in male mice. Endocrinology 2016;157:4257-65. *
Segarra N, Metastasio A, Ziauddeen H, Spencer J, Reinders NR, Dudas RB, Arrondo G, Robbins TW, Clark L, Fletcher PC, Murray GK. Abnormal frontostriatal activity during unexpected reward receipt in depression and schizophrenia: relationship to anhedonia. 2016;41:2001-10. *
Sferruzzi-Perri AN, López-Tello J, Fowden AL, Constancia M. Maternal and fetal genomes interplay through phosphoinositol 3-kinase(PI3K)-p110α signaling to modify placental resource allocation. Proc Natl Acad Sci USA. 2016;113:11255-60. *
Sleigh A, Lupson V, Thankamony A, Dunger DB, Savage DB, Carpenter TA, Kemp GJ. Simple and effective exercise design for assessing in vivo mitochondrial function in clinical applications using (31)P magnetic resonance spectroscopy. Sci Rep. 2016;6:19057. *
Sleigh A, Savage DB, Williams GB, Porter D, Carpenter TA, Brindle KM, Kemp GJ. 31P magnetization transfer measurements of Pi→ATP flux in exercising human muscle. J Appl Physiol (1985). 2016;120:649-56. *
Stewart S, Gessler F, Pluchino S, Moreau K. Inside-out: unpredicted Annexin A2 localisation on the surface of extracellular vesicles. Matters
Stewart ZA, Wilinska ME, Hartnell S, Temple RC, Rayman G, Stanley KP, Simmons D, Law GR, Scott EM, Hovorka R, Murphy HR. Closed-loop insulin delivery during pregnancy in women with type 1 diabetes. N Engl J Med. 2016;375:644-54.
Stewart ZA, Wilinska ME, Hartnell S, Temple RC, Rayman G, Stanley KP, Simmons D, Law GR, Scott EM, Hovorka R, Murphy HR. Closed-loop insulin delivery during pregnancy in women with type 1 diabetes. Obstetrical and Gynecological Survey 2016;71:699-701.
Stijnen P, Ramos-Molina B, O’Rahilly S, Creemers JW. PCSK1 mutations and human endocrinopathies: from obesity to gastrointestinal disorders. Endocr Rev. 2016;37:347-71.
Svendsen B, Pais R, Engelstoft MS, Milev NB, Richards P, Christiansen CB, Egerod KL, Jensen SM, Habib AM, Gribble FM, Schwartz TW, Reimann F, Holst JJ. GLP1- and GIP-producing cells rarely overlap and differ by bombesin receptor-2 expression and responsiveness. J Endocrinol. 2016;228:39-48.
Tan CY, Virtue S, Murfitt S, Roberts LD, Phua YH, Dale M, Griffin JL, Tinahones F, Scherer PE, Vidal-Puig A. Erratum: Adipose tissue fatty acid chain length and mono-unsaturation increases with obesity and insulin resistance. Sci Rep. 2016;6:23873. *
Tan HK, [8 authors], Evans ML, Shaw JA, Flanagan D. Low-blood glucose avoidance training improves glycemic variability in adults with type 1 diabetes complicated by impaired awareness of hypoglycemia: HypoCOMPaSS Trial. Diabetes Care 2016;39:e56-8.
Tarry-Adkins JL, Fernandez-Twinn DS, Chen JH, Hargreaves IP, Neergheen V, Aiken CE, Ozanne SE. Poor maternal nutrition and accelerated postnatal growth induces an accelerated aging phenotype and oxidative stress in skeletal muscle of male rats. Dis Model Mech. 2016;9:1221-1229. *
Tarry-Adkins JL, Fernandez-Twinn DS, Hargreaves IP, Neergheen V, Aiken CE, Martin-Gronert MS, McConnell JM, Ozanne SE. Coenzyme Q10 prevents hepatic fibrosis, inflammation, and oxidative stress in a male rat model of poor maternal nutrition and accelerated postnatal growth. Am J Clin Nutr. 2016;103:579-88. *
Tauschmann M, Allen JM, Wilinska ME, Thabit H, Acerini CL, Dunger DB, Hovorka R. Home use of day-and-night hybrid closed-loop insulin delivery in suboptimally controlled adolescents with type 1 diabetes: a 3-week, free-living, randomized crossover trial. Diabetes Care 2016;39:2019-25.
Tauschmann M, Allen JM, Wilinska ME, Thabit H, Stewart Z, Cheng P, Kollman C, Acerini CL, Dunger DB, Hovorka R. Day-and-night hybrid closed-loop insulin delivery in adolescents with type 1 diabetes: a free-living, randomized clinical trial. Diabetes Care 2016;39:1168-74.
Thabit H, Bally L, Hovorka R. Available at a flash: a new way to check glucose. Lancet 2016;388:2213-4.
Thabit H, Hartnell S, Allen JM, Lake A, Wilinska ME, Ruan Y, Evans ML, Coll AP, Hovorka R. Closed-loop insulin delivery in inpatients with type 2 diabetes: a randomised, parallel-group trial. Lancet Diabetes Endocrinol. 2016;pii: S2213-8587:30280-7.
Thankamony A, Capalbo D, Jonsson PJ, Simpson HL, Dunger DB. Predictors of insulin-like growth factor-I responses to growth hormone replacement in young adults with growth hormone deficiency. Horm Res Paediatr. 2016;85:379-88.
Thankamony A, Jensen RB, O’Connell SM, Day F, Kirk J, Donaldson M, Ivarsson SA, Söder O, Roche E, Hoey H, Ong KK, Dunger DB, Juul A. Adiposity in children born small for gestational age is associated with β-cell function, genetic variants for insulin resistance, and response to growth hormone treatment. J Clin Endocrinol Metab. 2016;101:131-42.
Thiebaud N, Llewellyn-Smith IJ, Gribble F, Reimann F, Trapp S, Fadool DA. The incretin hormone glucagon-like peptide 1 increases mitral cell excitability by decreasing conductance of a voltage-dependent potassium channel. J Physiol. 2016;594:2607-28. *
Tripolszki K, Knox R, Parker V, Semple R, Farkas K, Sulák A, Horváth E, Széll M, Nagy N. Somatic mosaicism of the PIK3CA gene identified in a Hungarian girl with macrodactyly and syndactyly. Eur J Med Genet. 2016;59:223-6.
Van De Pette M, Tunster SJ, McNamara GI, Shelkovnikova T, Millership S, Benson L, Peirson S, Christian M, Vidal-Puig A, John RM. Cdkn1c boosts the development of brown adipose tissue in a murine model of Silver Russell Syndrome. PLoS Genet. 2016;12:e1005916. *
van der Klaauw AA, Keogh JM, Henning E, Stephenson C, Kelway S, Trowse VM, Subramanian N, O’Rahilly S, Fletcher PC, Farooqi IS. Divergent effects of central melanocortin signalling on fat and sucrose preference in humans. Nat Commun. 2016;7:13055. *
Vinckier F, Gaillard R, Palminteri S, Rigoux L, Salvador A, Fornito A, Adapa R, Krebs MO, Pessiglione M, Fletcher PC. Confidence and psychosis: a neuro-computational account of contingency learning disruption by NMDA blockade. Mol Psychiatry. 2016;21:946-55.
Wang H, [19 authors, Savage DB: 8], Farese RV. Seipin is required for converting nascent to mature lipid droplets. Elife 2016;5. *
Yavari A, [52 authors; Yeo GS: 43], Ashrafian H. Chronic activation of γ2 AMPK induces obesity and reduces β cell function. Cell Metab. 2016;23:821-36. *
Yew Tan C, Virtue S, Murfitt S, Roberts LD, Phua YH, Dale M, Griffin JL, Tinahones F, Scherer PE, Vidal-Puig A. Adipose tissue fatty acid chain length and mono-unsaturation increases with obesity and insulin resistance. Sci Rep. 2015;5:18366. Erratum in: Sci Rep. 2016;6:23873. *
Zhou J, Lam B, Neogi SG, Yeo GS, Azizan EA, Brown MJ. Transcriptome pathway analysis of pathological and physiological aldosterone-producing human tissues. Hypertension 2016;68:1424-31. *
Ziauddeen H, Garcia-Rizo C, Bernardo M, Kirkpatrick B, Ozanne SE, Jones PB, Fernandez-Egea E. Association of birth weight and the development of antipsychotic induced adiposity in individuals with treatment resistant schizophrenia. Eur Neuropsychopharmacol. 2016;26:972-8.
Ziauddeen H, [15 authors], Fletcher PC, Bullmore ET. Opioid antagonists and the A118G polymorphism in the μ-opioid receptor gene: effects of GSK1521498 and naltrexone in healthy drinkers stratified by OPRM1 genotype. 2016;41:2647-57. *

Primary Research Publications

2022

2021

2020

2019

2018

2017

2016

Contact Us

Cookies & Privacy Policy

Intranet

Study at Cambridge

Primary Research Publications

2022

2021

2020

2019

2018

2017

2016

Contact Us

Cookies & Privacy Policy

Intranet

Study at Cambridge

About the University

Research at Cambridge