Wellcome-MRC Institute of Metabolic Science
Our goal is to develop new treatments for people living with severe obesity by delivering a step-change in our understanding of the control of human energy balance.
Techniques we use
Genetics and molecular biology as tools of identification of novel genes associated with obesity in humans. Physiological tools to study impact of genes on appetite and weight regulation in humans.
Team achievements
Sadaf Farooqi was presented with the Croonian Medal of the Royal Society with Professor Sir Stephen O’Rahilly in 2022.
We have started treating patients with several genetic conditions which cause obesity, as part of a new trial. This development is particularly exciting for us as we discovered many of these genetic conditions in patients recruited to the GOOS cohort.
Our highlight publication
Obesity-Associated GNAS Mutations and the Melanocortin Pathway
New England Journal of Medicine, 2021 October; PMID: 34614324
The New England Journal of Medicine selected our study on how obesity-associated GNAS mutations disrupt MC4R signalling for a Quick Take video!
If you’re too busy to read the whole paper, or would like a quick summary before diving in, you can watch the video on the NEJM website.
