Our research groups focus on mechanisms in disorders of energy balance.
Techniques we use
- Genetics/Whole Exome Sequencing
- Single cell/single nucleus RNA sequencing
- Spatial transcriptomics
- Clinical Research
- Whole animal physiology Cell-based research/stem cells
Giles Yeo was awarded the 2022 Society of Endocrinology Medal
Steve O’Rahilly (together with Sadaf Farooqi), were gave the 2022 Royal Society Croonian Lecture.
As part of the Cancer Grand Challenges initiative, Tony Coll as co-investigator (with Steve O’Rahilly and Giulia Biffi) on the CANCAN (CANcer Cachexia Action Network) team, exploring the underpinning mechanisms behind cancer cachexia.
Publications we are most proud of
MC3R links nutritional state to childhood growth and the timing of puberty Nature 2021 Nov 3.
In this paper we uncovered that the melanocortin 3 receptor (MC3R) links nutritional state to childhood growth and timing of puberty.
Lam BYH*, Williamson A*, Finer S, Day F, Tadross JA, Gonçalves Soares A, Wade K, Sweeney P, Bedenbaugh MN, Porter DT, Melvin A, Ellacott KLJ, Lippert RN, Buller S, Rosmaninho-Salgado J, Dowsett GKC, Ridley KE, Xu Z, Cimino I, Rimmington D, Rainbow K, Duckett K, Holmqvist S, Khan A, Dai X, Bochukova EG, Genes & Health Research Team, Trembath RC, Martin HC, Coll AP, Rowitch DH, Wareham NJ, van Heel DA, Timpson N, Simerly RB, Ong KK, Cone, RD, Langenberg C, Perry JRB, Yeo GSH, O’Rahilly S.
HypoMap – a unified single cell gene expression atlas of the murine hypothalamus. Nature Metabolism Oct 2022.
In a collaboration with colleagues at the Max Planck Institute for Metabolism Research, we have merged 18 large mouse single-cell datasets into an integrated reference atlas of the mouse hypothalamus we call ‘HypoMap’. This represents the most comprehensive database of its kind. It can serve as an important platform to unravel the functional organization of hypothalamic circuits, and to identify novel druggable targets for treating metabolic disorders.
Steuernagel L*, Lam BYH*, Klemm P, Dowsett GKC, Bauder CA, Tadross JA, Hitschfeld TS, del Rio Martin A, Chen W, Solis AJ, Fenselau H, Davidsen P, Cimino I, Kohnke SN, Rimmington D, Coll AP, Beyer A, Yeo GSH, Brüning JC.