Healthy mums, healthy babies, healthy families.
I am passionate about improving care for women and babies affected by gestational diabetes. This is a form of diabetes which develops during pregnancy and which normally disappears after delivery of the baby. However, it has short-term and long-term implications upon the health of both mum and baby. My main research interest focuses upon improving the health of women with gestational diabetes during pregnancy and in later life, and the health of their children.
DiGest: a dietary intervention in gestational diabetes. This study is a randomised controlled trial of a reduce energy diet in pregnant women with gestational diabetes. As excessive weight can cause problems during pregnancy, the aim of this study is to see if a reduction in the mother’s calorie intake can improve the health of mother and child both during and after pregnancy. As part of this study, pregnant mothers will receive 8-10 weeks of free food which will be nutritionally balanced for pregnancy, designed for women with gestational diabetes and delivered straight to their door. This is a cutting-edge, novel approach to running a nutritional interventional study and should have exciting and clinically-relevant findings to help improve care for mothers with gestational diabetes.
OPHELIA: this is a 4-year observational study of pregnant mothers to help identify and explain the causes of gestational diabetes. Although most women with high sugar (glucose) levels first identified in pregnancy are diagnosed with gestational diabetes, it is likely that there are different underlying causes to this condition. A better understanding of those causes could improve care for women and their babies. As part of this study, pregnant women who are being tested for diabetes will be asked to give additional blood samples.
CONCEPTt: This was a large multicentre randomised controlled trial of the use of continuous glucose monitoring in women with type 1 diabetes in pregnancy. I am analysing the data from CONCEPTt to understand better the biochemical and metabolic effects of diabetes in pregnancy and their consequences upon the growth of the baby. These analyses are funded by the European Foundation for the Study of Diabetes (EFSD).
GIFT: This study assesses the importance of glucose and metabolism upon men having fertility investigations.
In addition to my research, I also work as a doctor, seeing patients with diabetes in pregnancy, cholesterol/lipid disorders and obesity at my clinics at Addenbrooke’s Hospital, Cambridge and Peterborough City Hospital.
- Aiken CEM, Hone L, Murphy HR, Meek CL. Improving outcomes in gestational diabetes: does gestational weight gain matter? Diabetic Medicine 2018 accepted.
- Feig DS, Donovan LE, Corcoy R, Murphy KE, Amiel SA, Hunt KF, Asztalos E, Barrett JFR, Sanchez JJ, de Leiva A, Hod M, Jovanovic L, Keely E, McManus R, Hutton EK, Meek CL, Stewart ZA, Wysocki T, O’Brien R, Ruedy K, Kollman C, Tomlinson G, Murphy HR; CONCEPTT Collaborative Group. Continuous glucose monitoring in pregnant women with type 1 diabetes (CONCEPTT): a multicentre international randomised controlled trial. Lancet 2017; 390 (10110) , 2347 – 2359.
- Meek CL, Murphy HR, Simmons D. Random plasma glucose (RPG) in early pregnancy is a better predictor of gestational diabetes (GDM) diagnosis than maternal obesity. Diabetologia. 2016; 59(3): 445-52.
- Meek CL, Lewis HB, Vergese B, Park AJ, Reimann F, Gribble FM. The effect of encapsulated glutamine on gut peptide secretion in human volunteers. Peptides. 2016;77:38-46.
- Meek CL, Lewis HB, Patient C, Murphy HR, Simmons D. Diagnosis of gestational diabetes: falling through the net. Diabetologia 2015; 58(9):2003-12. This article was the subject of a press release featured on BBC news (12/6/2015) and during an interview on BBC Radio 4 (7/7/2015). My research into gestational diabetes is generously supported by Diabetes UK through the prestigious Harry Keen Intermediate Clinical Fellowship (PI). This grant is specifically for the DiGest clinical trial. I am also grateful to the European Foundation for the Study of Diabetes (EFSD) for funding assessment of glycaemic status in the CONCEPTt study (PI).