The mission of the Histopathology Core Facility is to offer IMS-MRL investigators high quality technical histology, interpretive pathology and necropsy services to support murine and other pre-clinical research models.

Histopathology, together with the Disease Model Core, Biochemistry Assay Lab and Imaging Core make the IMS-MRL one of only a few academic institutions in the UK capable of offering a complete phenotyping service for murine models of disease.

 

SERVICES PROVIDED

Technical:

• • Study design and optimisation relevant to histological end points
  • Advice/assistance on collection, trimming, sectioning and staining of fixed and frozen tissue
  • Tissue processing and embedding
  • Freezing of blocks in OCT
  • Microtomy and cryotomy
  • Haematoxylin & eosin staining; special stains
  • Immunohistochemistry/fluorescence optimisation and staining (routine and novel markers)
  • Training and supervision (theories, methods, necropsy, equipment, safety etc.)

 

Interpretive pathology:

• One-to-one slide review; pathology/morphology teaching
• Development of protocols for pathology endpoints
• Quantitative analysis of pathological findings; preparation of images for publication

 

 

To discuss any of our services please contact us using the link on the right.