The mission of the Histopathology Core Facility is to offer high quality technical histology, interpretive pathology and necropsy services to support murine and other pre-clinical research models.

Histopathology, together with the Disease Model Core, Biochemistry Assay Lab and Imaging Core make the IMS-MRL one of only a few academic institutions in the UK capable of offering a complete phenotyping service for murine models of disease.

 

SERVICES PROVIDED

Technical:

• Study design and optimisation relevant to histological end points.
• Advice and assistance on collection, trimming, sectioning and staining of fixed and frozen tissue.
• Processing of fixed tissue to wax block.
• Tissue freezing and OCT block creation.
• Microtomy and cryotomy.
• Haematoxylin and eosin staining.
• Special stains.
• Immunohistochemistry/fluorescence optimisation and staining (routine and novel markers).
• In situ hybridisation (RNAscope).
• IHC/RNAscope co-staining.
• Training and supervision (theory, methods, necropsy, equipment, safety etc.).

Interpretive pathology:

• One-to-one slide review; pathology/morphology teaching
• Development of protocols for pathology endpoints
• Quantitative analysis of pathological findings; preparation of images for publication

To discuss any of our services please contact us using the link on the right.