Thank you for your interest in this exciting Wellcome Trust-funded PhD Programme for Physicians, established in partnership between the Universities of Cambridge and East Anglia and the Wellcome Sanger Institute. The host institutions have a wide range of outstanding investigators who have agreed to act as faculty for this programme. These investigators will provide mentoring, workshops and mini-projects in order to allow the successful candidate to make an informed choice of project and supervisor. Thus, the project can be tailored to the interests of the candidate. This novel approach to the training of clinical scientists aims to provide the support and mentoring required to allow clinical academics to reach their full potential and pursue a successful academic career. We fully recognise that each individual will have a different background and current training position. Some will be academic clinical fellows whilst others will be on standard training programmes. Equally some individuals who are interested in epidemiology and public health or computational biology/bioinformatics may wish to undertake a taught MPhil to obtain sufficient knowledge before embarking on their PhD. These can all be accommodated within the scheme. All we ask is academic excellence, hard work and the will to make a difference to your chosen profession.