Joe Lee (Haematology)

“The epigenomic landscape and evolution in myeloproliferative neoplasms”

Supervisor: Prof Tony Green (Stem Cell Institute)/Dr Jyoti Nangalia (Sanger)

Jake Mann (Paediatrics/Metabolism)

“Human genetic evidence linking mitochondrial defects and adiposity”

Supervisor: Prof David Savage (Clin Biochem)

Sophie Momen (Dermatology)

“Xeroderma pigmentosum: a disease model to explore the biological processes

underlying mutational signatures identified in cancer, neurodegeneration and aging”

Supervisor: Dr Serena Nik-Zainal (Medical Genetics)

Dhruv Panchal (Neurology/Metabolism)

“Translating the neuroprotective effects of the cold-shock protein, RNA-binding motif 3

(RBM3)”

Supervisor: Prof Giovanna Mallucci (Clinical Neuroscience)

William Rae (Immunology)

“Investigation of genetic variants associated with primary immunodeficiency”

Supervisor: Prof Ken Smith (Medicine)

Philip Robinson (Paediatrics/GI)

“Exploring the landscape of somatic mutations in the gastrointestinal tract”

Supervisor: Professor Sir Mike Stratton (Sanger)

Michael Spencer Chapman (Haematology)

“Stem cell dynamics in human allogeneic transplantation through phylogenetic tracking”

Supervisor: Dr Peter Campbell (Sanger)

Benjamin Stewart (Renal Immunology)

“Investigating human kidney mononuclear phagocytes using single cell RNA sequencing”

Supervisor: Dr Menna Clatworthy (CIMR)/Dr Sarah Teichmann (Sanger)

Daniel Stubbs (Anaesthetics/Epidemiology)

“Designing optimal perioperative care for the elderly: systems engineering and data

analytical approach”

Supervisor: Prof John Clarkson (Dept of Engineering/ Prof David Menon (Anaesthesia)/

Dr Ari Ercole (Anaesthesia)

Cissy Yong (Urology)

“Investigating renal cancer metabolism using novel surgical methods”

Supervisor: Mr Grant Stewart (Surgery)/Dr Christian Frezza (MRC Cancer Unit)

David Bargiela (Clinical Neuroscience)

“The role of Factor Inhibiting HIF (FIH) in T lymphocyte fate determination”

Supervisor: Professor Randall Johnson (PDN)

Julia Becker (Neuroscience)

“Investigating stiffness alterations in spinal cord injury”

Supervisor: Dr Kristian Franze (PDN)

Pui Ying Chan (Oncology)

“Identification of collateral lethal gene pairs in uveal melanoma”

Supervisor: Dr David Adams (Sanger)

Joshua Elias (Gastroenterology)

“Elucidating the biology of G-protein coupled receptor 35 and its primary sclerosing

cholangitis risk associated coding polymorphism”

Supervisor: Prof Arthur Kaser (Medicine)

Margarete Fabre (Haematology)

“The pathogenesis and evolution of myeloid malignancies harbouring spliceosomal

gene mutations”

Supervisor: Dr George Vasilliou (Sanger)

Benjamin Fisher (Paediatrics)

“Epigenetic transgenerational inheritance of metabolic, reproductive, and endocrine

phenotypes through the male germline: effects of developmental bisphenol A and

dexamethasone exposure”

Supervisor: Prof Eric Miska (Gurdon Institute)

Alexandra Lake (Infectious Diseases)

“Mycobacterial determinants of extracellular success”

Supervisor: Prof Lalita Ramakrishnan (Medicine/LMB)

Emily Mitchell (Haematology)

“Population dynamics of human haematopoietic stem cells over the human lifespan”

Supervisor: Dr Peter Campbell (Sanger)

James Warland (Haematology)

“Investigation into the role of RBM8A/Y14 in the development and function of

megakaryocytes and platelets using a human pluripotent stem cell model of

haematopoiesis”

Supervisor: Dr Cedric Ghevaert (Haematology)

Adam Young (Neurosurgery)

“The influence of ageing on the ability of microglia to stimulate the regeneration

process of remyelination”

Supervisor: Prof Robin Franklin (Cambridge Stem Cell Institute)

Peter Bailey (Respiratory Medicine)

“The role of AB hydrolase domain containing 11 (ABHD11) in the regulation of the

hypoxia response”

Supervisor: Dr James Nathan (CIMR)

Anne Ramsay Bowden (Clinical Genetics)

“Investigating genetic and functional interactions within the human DNA damage

response using CRISPR-Cas9 technologies”

Supervisor: Prof Steve Jackson (Gurdon Institute)

Elizabeth Goode (Gastroenterology)

“Identifying cell types, genes and mechanism underlying susceptibility to Primary

Sclerosing Cholangitis”

Supervisor: Dr Carl Anderson (Sanger)

Emily Lees (Immunology)

“Interactions of Salmonellae with the host intestinal epithelium”

Supervisor: Prof Gordon Dougan (Sanger)

Ludovica Marando (Haematology)

“The role of the DNMT3A mutation in the subversion of normal Haematopoietic Stem

Cell (HSC) function and generation of preleukaemia”

Supervisor: Dr Brian Huntly (CIMR)

Norman Shreeve (Obstetrics and Gynaecology)

“The role of natural killer cells in murine reproductive success”

Supervisor: Dr Francesco Colucci (Dept of Obstetrics & Gynaecology)

Ondrej Suchanek (Immunology)

“Investigating the phenotype, function and interactions of tissue-resident B cells”

Supervisor: Dr Menna Clatworthy (Medicine)

Clare Burdett (Cardiothoracic Surgery)

“Characterisation of the mitral annulus and its dynamics to inform materials choice

for implant design in the surgical correction of degenerative mitral regurgitation”

Supervisor: Ruth Cameron & Serena Best (Materials Science & Metallurgy)

Grace Collord (Paediatric Haematology)

“Investigating the preclinical evolution of myeloid malignancies”

Supervisor: Dr George Vassiliou (Sanger)

Nirupa Desai (Haematology)

“To elucidate the structure of the mammalian mitrochondrial ribosome attached to its translocon”

Supervisor: Prof Venki Ramakrishnan (MRC LMB)

Harveer Dev (Surgical Oncology)

“Understanding drug resistance in cancers with DNA repair defects”

Supervisor: Prof Steve Jackson (Gurdon Institute)

Dan Greaves (Infectious Disease)

“A genetic and proteomic approach to reactivation of the Epstein-Barr Virus from

latent infection”

Supervisor: Prof Paul Lehner (CIMR)

Nicola Thompson (Medical Oncology)

“A reductionist approach to the analysis of melanoma driver genes”

Supervisor: Dr David Adams (Sanger)

Limy Wong (Renal Medicine)

“Integration of a comprehensive cellular and transcriptomic analysis of leukocyte

subsets with clinical outcome data in renal transplantation”

Supervisor: Prof Ken Smith (CIMR)

Sarah Aitken (Histopathology)

“Investigating the interplay between CTCF haploinsufficiency and DNA stability

using genomic and proteomic approaches”

Supervisor: Dr Duncan Odom (CRUK)

Ciaran Hill (Neurosurgery)

“Traumatic axonal injury and the role of neuroinflammation in progressive

neurodegeneration”

Supervisor: Prof David Menon (Anaesthesia)

Imran Noorani (Neurosurgery)

“Genome-wide screening for co-operative driver genes and chemotherapeutic

resistance genes of glioblastoma using transposon and CRISPR-cas9 mediated mutagenesis”

Supervisor: Prof Allan Bradley (Sanger)

Johannes Reinhold (Cardiology)

“Mitochondrial regulation of inflammation in atherosclerosis”

Supervisor: Prof Martin Bennett (Cardiovascular Medicine) 

Stephen Sammut (Oncology)

“The circulating genomic landscape of early stage breast cancer”

Supervisor: Prof Carlos Caldas (CRUK)

Kirsten Scott (Neurology)

“The role of B lymphocytes in the development of Parkinson’s disease and its

associated dementia”

Supervisor: Prof Roger Barker (Brain Repair)

Michelle Toleman (Medical Microbiology)

“A comparison of standard infection control practice, whole-genome sequencing and infection tracking software to optimise the detection of Methicillin Resistant Staphylococcus aureus transmission in health care facilities”

Supervisor: Prof Sharon Peacock (Medicine)/Prof Julian Parkhill (Sanger)

Faisal Basheer (Haematology)

“The role of EZH2 in the induction and maintenance of acute myeloid leukaemia”

Supervisor: Brian Huntly (CIMR)

Ranna El Khairi (Paediatric Endocrinology)

“Use of human pluripotent stem cells to model monogenic diabetes”

Supervisor: Ludovic Vallier (Sanger)

Saad Idris (Haematology)

“The role of the B cell receptor and downstream signalling pathways in Non Hodgkins Lymphoma”

Supervisor: Klaus Okkenhaug (Babraham)/Paul Kellam (Sanger)

Wajid Jawaid (Paediatric Surgery)

“Resolving early mesodermal fate decisions at the single cell level to identify

differentiation pathways and novel regulators”

Supervisor: Prof Bertie Gottgens (CIMR)

Simon Johnston (Medical Oncology)

“Biological characterisation of FoxA1 regulatory factors”

Supervisor: Jason Carroll (CRUK)/Ultan McDermott (Sanger)

Oliver Mytton (Public Health)

“Environmental approaches to walking and cycling: interventions, mechanisms and

health benefits”

Supervisor: David Ogilvie (MRC Epidemiology Unit)

Mabel Teng (Medical Oncology)

“The genetic landscape of circulating tumour cells and disseminated tumour cells in

breast cancer”

Supervisor: Peter Campbell/Thierry Voet (Sanger)

Zaeem Cader (Gastroenterology)

“Characterizing the role of GPR35 in inflammatory bowel disease”

Supervisor: Arthur Kaser (Dept of Medicine/Sanger)

Cristina Dias (Clinical Genetics)

“Unravelling the BAFopathies: high throughput molecular phenotyping of models of

BAF complex mutations associated with intellectual disability”

Supervisor: Darren Logan (Sanger)

Wendy Jones (Clinical Genetics)

“From monogenic to oligogenic: expanding the search for inheritance models in

intellectual disability”

Supervisor: Jeff Barrett (Sanger)

Thomas McKerrell (Haematology)

“The prevalence and significance of clonal selection in healthy haematopoietic stem

cells and its relationship to myeloid leukaemogenesis”

Supervisor: George Vassiliou (Sanger)

Marko Nikolic (Respiratory Medicine)

“Developmental studies of murine and human lung development towards differentiation

of human induced pluripotent stem cells to lung epithelial progenitors”

Supervisor: Emma Rawlins (Gurdon)

Rameen Shakur (Cardiology)

“Elucidating the development of ventricular tachyarrhythmias in familial hypertrophic

cardiomyopathies”

Supervisor: Derek Stemple (Sanger)

Tom Turmezei (Radiology)

“3D modelling of the hip joint from clinical imaging data”

Supervisor: Graham Treece (Engineering)/Ken Poole (Dept of Medicine)

Constantine Alifrangis (Medical Oncology)

“Evaluation of combinatorial drug strategies to combat de novo and acquired drug resistance to targeted molecular therapy”

Supervisor: Ultan McDermott (Sanger)

Neil Barrett (Paediatric Oncology)

“A study of the developmental biology of MLL-AF4 associated infantile leukaemia in a

mouse model”

Supervisor: Katrin Ottersbach (CIMR)

Sam Behjati (Paediatrics)

“Genomic profile of radiation-induced cancer”

Supervisor: Mike Stratton (Sanger)

Marc-Philip Hitz (Cardiovascular)

“Genetic determinants in left ventricular outflow tract obstruction”

Supervisor: Matthew Hurles (Sanger)

James (Jimmy) Peters (Rheumatology)

“Regulation of gene expression in immune cell subsets in health and disease”

Supervisor: Ken Smith (CIMR)

Clara Podmore (nee Kelliny) (Metabolism)

“Iron metabolism and its association with type 2 diabetes”

Supervisor: Claudia Langenberg (MRC Epidemiology Unit)

Lucy Yates (Clinical Oncology)

“Characterisation of the evolving genomic landscape in cancer relapse and metastasis”

Supervisor: Peter Campbell (Sanger)