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IMS-MRL seminars are primarily for staff and invited guests. External events open to a wider audience are included where appropriate.

NB: Since the Covid-19 pandemic we are  running the IMS-MRL Tuesday seminar series as hybrid events or online only via Zoom. Please check the events calendar for details.


The IMS-MRL seminar series:  taking place weekly during term time, with occasional seminars from visiting scientists.


  • External Research Seminars (on Tuesdays at 1.15pm – invited audience only); – sponsored by Astra Zeneca


  • Internal ‘Research in Progress’ Seminars (on Tuesday at 1.15pm -staff only)


  • Internal ‘Hot Topics’ and ‘Technical’ Seminars (on Thursday at 2.30pm) for 1st year PhD and post-graduate students)


  • Mastering Academic Excellence in Metabolic Medicine (MAXIM), sponsored by Eli Lilly. (on Fridays at 1.15pm; sandwiches available from 1.00pm)
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Dr Sophie Trefely, Signalling and Epigenetics, The Babraham Institute, Cambridge – ‘Compartmentalised metabolism and metabolite signalling to the nucleus’

February 14 @ 1:15 pm - 2:15 pm

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Speaker: Dr Sophie Trefely, Signalling and Epigenetics, The Babraham Institute, Cambridge

Title: Compartmentalised metabolism and metabolite signalling to the nucleus


Host: Daniel Fazakerley

Time: 13.15



Intracellular metabolites act as powerful signalling cues to adjust cell behaviour to the nutrient environment. A variety of metabolites operate in the nucleus as substrates, co-factors, or inhibitors of chromatin-modifying enzymes and have emerged as key determinants of gene regulation. Given that cellular metabolism is highly compartmentalized, our understanding of pathways connecting nutrients to nuclear metabolites has been limited since standard metabolite analyses use whole cells. I will talk about my recent work on the development of novel approaches for sub-cellular metabolite analyses by mass spectrometry, with a focus on the acyl-Coenzyme A metabolite class. This work shows that the nucleus operates as a distinct metabolic compartment and marks an exciting step forward in understanding regulation of metabolism within the nucleus and how this links diet to the epigenome.


For programme information or suggestions contact:
Dr Daniel Fazakerley djf72 at,
Professor Giles Yeo gshy2 at
Dr Anthony Coll apc36 at


February 14
1:15 pm - 2:15 pm
Event Category:


Wellcome-MRC Institute of Metabolic Science