Wellcome-MRC Institute of Metabolic Science
NEWS UPDATE (7 March): We are delighted to report that Orla won the Nutrition Society prize at yesterday’s STEM for Britain competition. Orla Woodward, 27, a PhD student in the Gribble/Reimann group at the IMS-MRL, is attending Parliament to present her research to a range of politicians and a panel of expert judges, as […]
Dysregulation of lipid metabolism can be seen after apparent return to normal health in mice used as a proxy for gestational diabetes
There is mounting evidence of increased risk of type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD) in women who, when pregnant, experienced gestational diabetes (GDM). The elevated risk is observed in the decade after delivery. In their study published in Nutrition and Diabetes, researchers from the Ozanne and Koulman groups studied mice fed on […]
How body tissues are affected by poly-unsaturated fatty acid dietary supplements
Poly-unsaturated fatty acid (PUFA) supplements have been used in clinical trials as a treatment for a number of conditions, including fatty liver disease, cardiovascular disease and cognition or mood disorders. The varied results can be due to the particular mixture of supplements used, as can the effects in different organs and tissues. A study by Samuel Furse, Albert […]
Human stem cell lines: separating the wheat from the chaff
A collaborative effort led by Florian Merkle used whole genome sequencing (WGS) to analyse 143 commonly used human pluripotent stem cell (hPSC) lines at single nucleotide resolution and use the resulting insights to rationally select those most suitable for a given purpose. HPSCs are remarkable since they can self-renew indefinitely while retaining the ability to […]
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