Research from the Gribble-Reimann group and published this week in Cell Reports has demonstrated the ability to label and maintain fully functional human L-cells in organoid culture. This opens opportunities to explore L-cell function and develop drugs targeting the human enteroendocrine system. Enteroendocrine cells (EECs) produce a range of gut hormones that have key roles […]
When two pandemics meet: Why is obesity associated with increased COVID-19 mortality?
A perspective article by Steve O’Rahilly and Sam Lockhart, published this week in MED (a new Cell Press journal) presents hypotheses about the deleterious impact of obesity on the course of COVID-19. There is a growing body of evidence indicating that obesity is strongly and independently associated with adverse outcomes of COVID-19 including death. They […]
Wellcome Joint Investigator Award
Congratulations to Fiona Gribble and Frank Reimann who have received a prestigious Wellcome Joint Investigator Award. The five year grant ‘Targeting the gut in metabolic disease,’ will allow the group to investigate the cellular mechanisms of gut hormone secretion in human organoid models, and explore how the gut endocrine axis in humans is affected by […]
How does fatty liver progress toward non-alcoholic steatohepatitis (NASH) and end-stage liver disease
In a paper published this month in Nature Metabolism, researchers have identified the bone morphogenetic protein 8B (BMP8B), as a new driver of non-alcoholic steatohepatitis (NASH), promoting inflammation, and disease progression. Obesity is commonly associated with non-alcoholic fatty liver disease (NAFLD) that can progress to non-alcoholic steatohepatitis (NASH), as a consequence of lipotoxicity that drives […]
- 1
- 2
- 3
- …
- 20
- Next Page »
