MC4R is one of the key regulators of body weight in humans. Variants in MC4R are the most commonly identified genetic cause of obesity. In collaborative work published in Cell, Prof Sadaf Farooqi’s group at MRL and the team from the MRC Epidemiology Unit led by Dr Claudia Langenberg and Prof Nick Wareham, have demonstrated […]
Steroid Receptor Coactivator (SRC)-1 modulates leptin signalling in the hypothalamus
Work led by Prof Sadaf Farooqi’s team, in collaboration with Yong Xu’s lab (Baylor College of Medicine, Houston), published today in Nature Communications describes the role of Steroid Receptor Coactivator (SRC)-1 in modulating leptin signalling in hypothalamic Pomc neurons. The team showed that conditional knock-out of SRC-1 in Pomc neurons leads to increased food intake […]
Dose-dependent effects of genetic PI3K activation in human pluripotent stem cells
In a paper published in PNAS, research carried out by PhD student Ralitsa Madsen and colleagues from Robert Semple’s group (now based in Edinburgh) has identified dose-dependent effects on stemness in response to genetic activation of class IA PI3-kinase (PI3K) and prompts re-evaluation of the widely-held belief that PIK3CA mutations are strictly heterozygous in cancer. […]
Low levels of oxygen in the womb may cause fertility issues in daughters
Researchers from the Ozanne group, working in collaboration with the Giussani lab (Dept. Physiology, Development and Neuroscience) have found that exposing rat fetuses to hypoxia (low oxygen levels) during development led to advanced ageing of ovaries and fewer eggs available in female offspring. The team found a decrease in the number of ovarian follicles in […]
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