Using whole exome and targeted sequencing in 2,737 severely obese cases and 6,704 controls, Prof Farooqi’s team in collaboration with Prof Barroso and her team, identified three genes (PHIP, DGKI, and ZMYM4) enriched with deleterious variants in obese cases. PHIP was of particular interest as changes in this gene have been found in children with […]
How do proliferating liver cells ‘rewire’ metabolism in regeneration and cancer?
In a paper published this month in Hepatology, researchers demonstrate a coherent remodelling of metabolic pathways in hepatocytes during liver regeneration and in hepatocellular carcinoma (HCC). The liver is one of the most active metabolic organs of the human body, characterised by a high degree of plasticity that allows regeneration and healing following acute and […]
Metabolome-wide effects of leptin profiled in patients
In work published in the Journal of Clinical Endocrinology & Metabolism, Prof Sadaf Farooqi and her team used metabolomic profiling to understand leptin’s effects on peripheral metabolism. Rare patients with congenital leptin deficiency have hyperphagia and severe early onset obesity, which is treatable with injections of recombinant leptin. Comparison of metabolome profiles in patients before […]
COVID-19 PPE appeal fund
Week beginning May 18: ‘climb’ to support the appeal! The Virtual Climbing Challenge is raising money for the 4C PPE Appeal this week by encouraging you to ‘climb’ at home. You could tackle King’s College Chapel (210 steps), The Shard (1800 steps), Mount Everest (52,047 steps) or something in between. HOW TO TAKE PART […]
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