In a study carried out at the Wellcome-MRC Institute of Metabolic Science (IMS) Translational Research Facility (TRF) in Cambridge,women with eating disorders were assessed to establish whether stress led to loss of control in eating behaviours. Researchers from the University of Cambridge Department of Psychiatry, supervised by Professor Paul Fletcher and Dr Hisham Ziauddeen – […]
MC4R regulates body weight through multiple cellular mechanisms
The brain expressed Melanocortin 4 receptor (MC4R) plays a critical role in regulating appetite and weight. Geneticvariants in MC4R represent the commonest monogenic form of severe obesity, being found in up to 6% of the GOOS cohort; over 300 MC4R variants have been identified by teams around the world to date (www.mc4r.org.uk). In […]
Setmelanotide approved by the FDA for treatment of genetic obesity syndromes
Rhythm Pharmaceuticals has just announced that the US Food and Drug Administration (FDA) has approved the MC4R agonist, IMCIVREE™ (setmelanotide) for chronic weight management in adult and paediatric patients 6 years of age and older with obesity due to proopiomelanocortin (POMC), proprotein convertase subtilisin/kexin type 1 (PCSK1), or leptin receptor (LEPR) deficiency. This is great […]
Dr Hisham Ziauddeen – RCPsych 2020 Psychiatric Communicator of the Year
Congratulations to Dr Hisham Ziauddeen on being announced as Psychiatric Communicator of the Year in the Royal College of Psychiatrists’ Annual Awards. Hisham is a consultant psychiatrist in early intervention at Cambridgeshire and Peterborough Foundation Trust and a Senior Research Associate working with Professor Paul Fletcher at the Wellcome-MRC Institute of Metabolic Science. He is […]
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