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Congratulations to Dr Robert Semple on the award of a highly prestigious Senior Clinical Fellowship by the Wellcome Trust

This 5-year award of £1.6M award will enable recent findings of novel human genetic disorders of insulin action to be extended into cellular and murine model systems. The first goal will be to increase understanding of the mechanisms linking genetic defects in either the PI3K/AKT pathway or in DNA damage response signalling to the extreme human disease phenotypes we have observed. A major secondary aim is to gain insights into the fundamental role of these pathways in common forms of disease including diabetes, liver disease, reduced fertility and cancer.