Research Interests
Diabetes Technology
We are interested in using diabetes technology to improve life in people with diabetes and related conditions. Specifically we are developing and clinically testing the artificial pancreas in various populations. The artificial pancreas consists of a subcutaneous glucose monitor, a control algorithm, and an insulin pump. Our work includes the development of computer-based simulations for pre-clinical evaluation and optimisation of the artificial pancreas.
Selected Publications
Bally L, Thabit H, Kojzar H, Mader JK, Qerimi-Hyseni J, Hartnell S, Tauschmann M, Allen JM, Wilinska ME, Pieber TR, Evans ML, Hovorka R. (2017). Day-and-night glycaemic control with closed-loop insulin delivery versus conventional insulin pump therapy in free-living adults with well controlled type 1 diabetes: an open-label, randomised, crossover study. Lancet Diabetes Endocrinol. 2017 Apr;5(4):261-270. doi: 10.1016/S2213-8587(17)30001-3. Epub 2017 Jan 14. PMID:28094136.
Stewart ZA, Wilinska ME, Hartnell S, Temple RC, Rayman G, Stanley KP, Simmons D, Law GR, Scott EM, Hovorka R, Murphy HR. (2016). Closed-Loop Insulin Delivery during Pregnancy in Women with Type 1 Diabetes. N Eng J Med. 2016 Aug 18;375(7):644-54, doi: 10.1056/NEJMoa1602494. PMID:27532830.
Thabit H, Tauschmann M, Allen JM, Leelarathna L, Hartnell S, Wilinska ME, Acerini CL, Dellweg S, Benesch C, Heinemann L, Mader JK, Holzer M, Kojzar H, Exall J, Yong J, Pichierri J, Barnard KD, Kollman C, Cheng P, Hindmarsh PC, Campbell FM, Arnolds S, Pieber TR, Evans ML, Dunger DB, Hovorka R; APCam Consortium; AP@home Consortium. (2015). Home Use of an Artificial Beta Cell in Type 1 Diabetes. N Engl J Med. 2015 Nov 26;373(22):2129-40. doi: 10.1056/NEJMoa1509351. Epub 2015 Sep 17. PMID:26379095. PMCID:PMC4697362.
Bally L, Thabit H, Hartnell S, Andereggen E, Ruan Y, Wilinska ME, Evans ML,Wertli MM, Coll AP, Stettler C, Hovorka R. Closed-Loop Insulin Delivery forGlycemic Control in Noncritical Care. N Engl J Med. 2018 Aug 9;379(6):547-556.doi: 10.1056/NEJMoa1805233. Epub 2018 Jun 25. PubMed PMID: 29940126.
Tauschmann M, Thabit H, Bally L, Allen JM, Hartnell S, Wilinska ME, Ruan Y,Sibayan J, Kollman C, Cheng P, Beck RW, Acerini CL, Evans ML, Dunger DB, Elleri D, Campbell F, Bergenstal RM, Criego A, Shah VN, Leelarathna L, Hovorka R; APCam11 Consortium. Closed-loop insulin delivery in suboptimally controlled type 1 diabetes: a multicentre, 12-week randomised trial. Lancet. 2018 Oct 13;392(10155):1321-1329. doi: 10.1016/S0140-6736(18)31947-0. Epub 2018 Oct Erratum in: Lancet. 2018 Oct 13;392(10155):1310. PubMed PMID: 30292578; PubMed Central PMCID: PMC6182127.
Boughton CK, Bally L, Martignoni F, Hartnell S, Herzig D, Vogt A, Wertli MM,Wilinska ME, Evans ML, Coll AP, Stettler C, Hovorka R. Fully closed-loop insulin delivery in inpatients receiving nutritional support: a two-centre, open-label,randomised controlled trial. Lancet Diabetes Endocrinol. 2019 May;7(5):368-377.doi: 10.1016/S2213-8587(19)30061-0. Epub 2019 Mar 29. PubMed PMID: 30935872;PubMed Central PMCID: PMC6467839.
Tauschmann M, Allen JM, Nagl K, Fritsch M, Yong J, Metcalfe E, Schaeffer D,Fichelle M, Schierloh U, Thiele AG, Abt D, Kojzar H, Mader JK, Slegtenhorst S,Barber N, Wilinska ME, Boughton C, Musolino G, Sibayan J, Cohen N, Kollman C,Hofer SE, Fröhlich-Reiterer E, Kapellen TM, Acerini CL, de Beaufort C, Campbell F, Rami-Merhar B, Hovorka R; KidsAP Consortium. Home Use of Day-and-Night Hybrid Closed-Loop Insulin Delivery in Very Young Children: A Multicenter, 3-Week,Randomized Trial. Diabetes Care. 2019 Apr;42(4):594-600. doi: 10.2337/dc18-1881. Epub 2019 Jan 28. PubMed PMID: 30692242.
