The Core Metabolomics and Lipidomics Laboratory (CMaLL) is a technology ‘hub’, working on technological advances in metabolomics and lipidomics measurement and analysis that will contribute to biomedical innovation in diseases where metabolism is perturbed. CMaLL works collaboratively to identify and validate metabolic markers that can be used in diagnosis and prognosis of disease and treatment, providing the complete pipeline from experimental design, sample preparation, analysis, data processing and bioinformatics.
CMaLL uses both high-resolution mass spectrometry as well as tandem mass spectrometry for the qualitive and quantitative analysis of biological samples, which can be based on liquid chromatography or direct infusion nanospray ionisation. Dedicated data processing and data analysis pipelines are available and constantly updated and improved.
Standard methods are available for comprehensive lipid profiling, lipid quantitation and general aqueous metabolite profiling. Targeted methods for specific metabolites can be set-up or developed. CMaLL works closely with other metabolomics and lipidomics groups in Cambridge such as Prof Jules Griffin, dept of Biochemistry and contributes to national efforts on the development of standardised workflows for processing metabolomics data to aid reproducible data sharing and big data initiatives (MetaboFlow).
For all enquiries regarding use of and initial training of metabolomics and lipidomics methods, please contact Albert Koulman (firstname.lastname@example.org) or Ben Jenkins (email@example.com).