This programme of research focuses on the role of fat tissue in mediating the link between obesity, diabetes and cardiovascular problems through a mechanism involving toxic effects of fat.
Specifically we aim to:
- establish mechanisms controlling how the adipose tissue grows to learn how to prevent the metabolic problems typically associated with obesity such as diabetes and heart attacks;
- define whether targeting the brown adipose tissue, a type of fat that makes heat may prevent or reverse obesity associated complications;
- identify diagnostic biomarkers and treatments based on patterns of lipids in mice, for subsequent confirmation in humans.
These objectives will be addressed through a multidisciplinary approach that involves studying mice, with state of the art in vivo and in vitro characterisation, and advanced computational systems to integrate the information.