A functional link between a cluster of non-coding RNAs implicated in Prader-Willi Syndrome (PWS) and dysregulation of energy homeostasis has been demonstrated by research from the group of Anthony Coll, Steve O’Rahilly and Giles Yeo, which was recently published in The Journal of Clinical Investigation. The study created a new mouse model of the disease, […]
In research published in PNAS, a team of researchers has shown that loss of the gene called ‘TMEM18’ causes weight gain, while specifically overexpressing this gene in a small part of the hypothalamus results in weight loss. An understanding of the mechanisms underlying body-weight regulation is crucial to tackle the growing problem of obesity. Although […]
On Feb 1st Prof Sir Steve O’Rahilly reprised his 2016 Harveian Oration, originally given to Fellows of the Royal College of Physicians, for the Department of Medicine Grand Round series.
Prof Sadaf Farooqi shared her life scientific with Radio 4’s Prof Jim Al-Khalili, talking about her career in science and the discovery of rare genetic defects that can lead to obesity. In 1997, Sadaf noticed that two children she was studying lacked the hormone leptin. From there, she went on to discover the first single […]